FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:TET2-OSTC (FusionGDB2 ID:89548)

Fusion Gene Summary for TET2-OSTC

check button Fusion gene summary
Fusion gene informationFusion gene name: TET2-OSTC
Fusion gene ID: 89548
HgeneTgene
Gene symbol

TET2

OSTC

Gene ID

54790

58505

Gene nametet methylcytosine dioxygenase 2oligosaccharyltransferase complex non-catalytic subunit
SynonymsKIAA1546|MDSDC2
Cytomap

4q24

4q25

Type of geneprotein-codingprotein-coding
Descriptionmethylcytosine dioxygenase TET2probable methylcytosine dioxygenase TET2tet oncogene family member 2oligosaccharyltransferase complex subunit OSTChydrophobic protein HSF-28oligosaccharyltransferase complex subunit (non-catalytic)
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000545826, ENST00000513237, 
ENST00000540549, ENST00000380013, 
ENST00000305737, ENST00000394764, 
ENST00000504042, ENST00000413648, 
ENST00000361564, ENST00000512478, 
ENST00000505745, 
Fusion gene scores* DoF score11 X 6 X 11=7262 X 2 X 2=8
# samples 152
** MAII scorelog2(15/726*10)=-2.27500704749987
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: TET2 [Title/Abstract] AND OSTC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTET2(106111662)-OSTC(109588403), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTET2

GO:0006211

5-methylcytosine catabolic process

24315485

HgeneTET2

GO:0006493

protein O-linked glycosylation

23222540

HgeneTET2

GO:0080111

DNA demethylation

24315485


check buttonFusion gene breakpoints across TET2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across OSTC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-BP-4770-01ATET2chr4

106111662

+OSTCchr4

109588403

+


Top

Fusion Gene ORF analysis for TET2-OSTC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000545826ENST00000361564TET2chr4

106111662

+OSTCchr4

109588403

+
intron-3CDSENST00000545826ENST00000512478TET2chr4

106111662

+OSTCchr4

109588403

+
intron-intronENST00000545826ENST00000505745TET2chr4

106111662

+OSTCchr4

109588403

+
intron-3CDSENST00000513237ENST00000361564TET2chr4

106111662

+OSTCchr4

109588403

+
intron-3CDSENST00000513237ENST00000512478TET2chr4

106111662

+OSTCchr4

109588403

+
intron-intronENST00000513237ENST00000505745TET2chr4

106111662

+OSTCchr4

109588403

+
intron-3CDSENST00000540549ENST00000361564TET2chr4

106111662

+OSTCchr4

109588403

+
intron-3CDSENST00000540549ENST00000512478TET2chr4

106111662

+OSTCchr4

109588403

+
intron-intronENST00000540549ENST00000505745TET2chr4

106111662

+OSTCchr4

109588403

+
5UTR-3CDSENST00000380013ENST00000361564TET2chr4

106111662

+OSTCchr4

109588403

+
5UTR-3CDSENST00000380013ENST00000512478TET2chr4

106111662

+OSTCchr4

109588403

+
5UTR-intronENST00000380013ENST00000505745TET2chr4

106111662

+OSTCchr4

109588403

+
5UTR-3CDSENST00000305737ENST00000361564TET2chr4

106111662

+OSTCchr4

109588403

+
5UTR-3CDSENST00000305737ENST00000512478TET2chr4

106111662

+OSTCchr4

109588403

+
5UTR-intronENST00000305737ENST00000505745TET2chr4

106111662

+OSTCchr4

109588403

+
5UTR-3CDSENST00000394764ENST00000361564TET2chr4

106111662

+OSTCchr4

109588403

+
5UTR-3CDSENST00000394764ENST00000512478TET2chr4

106111662

+OSTCchr4

109588403

+
5UTR-intronENST00000394764ENST00000505745TET2chr4

106111662

+OSTCchr4

109588403

+
3UTR-3CDSENST00000504042ENST00000361564TET2chr4

106111662

+OSTCchr4

109588403

+
3UTR-3CDSENST00000504042ENST00000512478TET2chr4

106111662

+OSTCchr4

109588403

+
3UTR-intronENST00000504042ENST00000505745TET2chr4

106111662

+OSTCchr4

109588403

+
intron-3CDSENST00000413648ENST00000361564TET2chr4

106111662

+OSTCchr4

109588403

+
intron-3CDSENST00000413648ENST00000512478TET2chr4

106111662

+OSTCchr4

109588403

+
intron-intronENST00000413648ENST00000505745TET2chr4

106111662

+OSTCchr4

109588403

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for TET2-OSTC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TET2chr4106111662+OSTCchr4109588402+2.74E-060.99999726
TET2chr4106111662+OSTCchr4109588402+2.74E-060.99999726

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for TET2-OSTC


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for TET2-OSTC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for TET2-OSTC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for TET2-OSTC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for TET2-OSTC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTET2C0001815Primary Myelofibrosis2ORPHANET
HgeneTET2C0002893Refractory anemias2ORPHANET
HgeneTET2C0002894Refractory anaemia with excess blasts2ORPHANET
HgeneTET2C0026987Myelofibrosis2ORPHANET
HgeneTET2C0040028Thrombocythemia, Essential2ORPHANET
HgeneTET2C0079774Peripheral T-Cell Lymphoma2CTD_human
HgeneTET2C1264195Refractory anemia with ringed sideroblasts2ORPHANET
HgeneTET2C2713368Hematopoetic Myelodysplasia2CTD_human
HgeneTET2C3463824MYELODYSPLASTIC SYNDROME2CGI;CTD_human;GENOMICS_ENGLAND
HgeneTET2C0007134Renal Cell Carcinoma1CTD_human
HgeneTET2C0009402Colorectal Carcinoma1CTD_human
HgeneTET2C0009404Colorectal Neoplasms1CTD_human
HgeneTET2C0020981Angioimmunoblastic Lymphadenopathy1CTD_human
HgeneTET2C0023487Acute Promyelocytic Leukemia1CTD_human
HgeneTET2C0027643Neoplasm Recurrence, Local1CTD_human
HgeneTET2C0032463Polycythemia Vera1ORPHANET
HgeneTET2C0033578Prostatic Neoplasms1CTD_human
HgeneTET2C0036920Sezary Syndrome1CTD_human
HgeneTET2C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneTET2C0376358Malignant neoplasm of prostate1CTD_human
HgeneTET2C1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneTET2C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneTET2C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneTET2C1292773Acute myeloid leukemia with multilineage dysplasia1ORPHANET
HgeneTET2C1301365Systemic mastocytosis with associated clonal, hematologic non-mast-cell lineage disease1ORPHANET
HgeneTET2C1306837Papillary Renal Cell Carcinoma1CTD_human