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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:TET3-DGUOK (FusionGDB2 ID:89558) |
Fusion Gene Summary for TET3-DGUOK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TET3-DGUOK | Fusion gene ID: 89558 | Hgene | Tgene | Gene symbol | TET3 | DGUOK | Gene ID | 200424 | 1716 |
| Gene name | tet methylcytosine dioxygenase 3 | deoxyguanosine kinase | |
| Synonyms | BEFAHRS|hCG_40738 | MTDPS3|NCPH|PEOB4|dGK | |
| Cytomap | 2p13.1 | 2p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | methylcytosine dioxygenase TET3probable methylcytosine dioxygenase TET3putative methylcytosine dioxygenasetet oncogene family member 3 | deoxyguanosine kinase, mitochondrial | |
| Modification date | 20200314 | 20200313 | |
| UniProtAcc | . | Q16854 | |
| Ensembl transtripts involved in fusion gene | ENST00000409262, | ENST00000264093, ENST00000348222, ENST00000462685, ENST00000356837, | |
| Fusion gene scores | * DoF score | 17 X 13 X 11=2431 | 5 X 5 X 3=75 |
| # samples | 26 | 6 | |
| ** MAII score | log2(26/2431*10)=-3.22496636500027 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TET3 [Title/Abstract] AND DGUOK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | TET3(74317174)-DGUOK(74184252), # samples:2 TET3(74230293)-DGUOK(74173846), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DGUOK | GO:0046122 | purine deoxyribonucleoside metabolic process | 8706825 |
| Fusion gene breakpoints across TET3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across DGUOK (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-BH-A0BZ-01A | TET3 | chr2 | 74317174 | + | DGUOK | chr2 | 74184252 | + |
| ChimerDB4 | LGG | TCGA-S9-A6WL | TET3 | chr2 | 74230293 | + | DGUOK | chr2 | 74173846 | + |
| ChimerDB4 | BRCA | TCGA-BH-A0BZ-01A | TET3 | chr2 | 74317174 | - | DGUOK | chr2 | 74184252 | + |
| ChimerDB4 | LGG | TCGA-S9-A6WL-01A | TET3 | chr2 | 74230293 | - | DGUOK | chr2 | 74173846 | + |
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Fusion Gene ORF analysis for TET3-DGUOK |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000409262 | ENST00000264093 | TET3 | chr2 | 74317174 | + | DGUOK | chr2 | 74184252 | + |
| 5CDS-intron | ENST00000409262 | ENST00000348222 | TET3 | chr2 | 74317174 | + | DGUOK | chr2 | 74184252 | + |
| 5CDS-intron | ENST00000409262 | ENST00000462685 | TET3 | chr2 | 74317174 | + | DGUOK | chr2 | 74184252 | + |
| 5CDS-intron | ENST00000409262 | ENST00000356837 | TET3 | chr2 | 74317174 | + | DGUOK | chr2 | 74184252 | + |
| intron-3CDS | ENST00000409262 | ENST00000264093 | TET3 | chr2 | 74230293 | + | DGUOK | chr2 | 74173846 | + |
| intron-3CDS | ENST00000409262 | ENST00000348222 | TET3 | chr2 | 74230293 | + | DGUOK | chr2 | 74173846 | + |
| intron-3UTR | ENST00000409262 | ENST00000462685 | TET3 | chr2 | 74230293 | + | DGUOK | chr2 | 74173846 | + |
| intron-3UTR | ENST00000409262 | ENST00000356837 | TET3 | chr2 | 74230293 | + | DGUOK | chr2 | 74173846 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000409262 | TET3 | chr2 | 74317174 | + | ENST00000264093 | DGUOK | chr2 | 74184252 | + | 3102 | 2634 | 0 | 2876 | 958 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000409262 | ENST00000264093 | TET3 | chr2 | 74317174 | + | DGUOK | chr2 | 74184252 | + | 0.004394241 | 0.99560577 |
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Fusion Genomic Features for TET3-DGUOK |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| TET3 | chr2 | 74317174 | + | DGUOK | chr2 | 74184251 | + | 0.9740683 | 0.02593172 |
| TET3 | chr2 | 74317174 | + | DGUOK | chr2 | 74184251 | + | 0.9740683 | 0.02593172 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for TET3-DGUOK |
| Go to FGviewer for the breakpoints of chr2:74317174-chr2:74184252 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | DGUOK |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine (PubMed:8692979, PubMed:8706825, PubMed:11687801, PubMed:17073823, PubMed:23043144). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (By similarity). Widely used as target of antiviral and chemotherapeutic agents. {ECO:0000250|UniProtKB:Q9QX60, ECO:0000269|PubMed:11687801, ECO:0000269|PubMed:17073823, ECO:0000269|PubMed:23043144, ECO:0000269|PubMed:8692979, ECO:0000269|PubMed:8706825}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TET3 | chr2:74317174 | chr2:74184252 | ENST00000409262 | + | 5 | 9 | 50_90 | 878.0 | 1661.0 | Zinc finger | CXXC-type |
| Tgene | DGUOK | chr2:74317174 | chr2:74184252 | ENST00000264093 | 3 | 7 | 206_208 | 197.0 | 278.0 | Nucleotide binding | ATP | |
| Tgene | DGUOK | chr2:74317174 | chr2:74184252 | ENST00000264093 | 3 | 7 | 254_256 | 197.0 | 278.0 | Nucleotide binding | ATP | |
| Tgene | DGUOK | chr2:74317174 | chr2:74184252 | ENST00000348222 | 0 | 5 | 206_208 | 0 | 190.0 | Nucleotide binding | ATP | |
| Tgene | DGUOK | chr2:74317174 | chr2:74184252 | ENST00000348222 | 0 | 5 | 254_256 | 0 | 190.0 | Nucleotide binding | ATP | |
| Tgene | DGUOK | chr2:74317174 | chr2:74184252 | ENST00000348222 | 0 | 5 | 45_53 | 0 | 190.0 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TET3 | chr2:74317174 | chr2:74184252 | ENST00000409262 | + | 5 | 9 | 1688_1690 | 878.0 | 1661.0 | Region | 2-oxoglutarate binding |
| Hgene | TET3 | chr2:74317174 | chr2:74184252 | ENST00000409262 | + | 5 | 9 | 1694_1696 | 878.0 | 1661.0 | Region | Substrate binding |
| Tgene | DGUOK | chr2:74317174 | chr2:74184252 | ENST00000264093 | 3 | 7 | 45_53 | 197.0 | 278.0 | Nucleotide binding | ATP |
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Fusion Gene Sequence for TET3-DGUOK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000409262_ENST00000264093_TCGA-BH-A0BZ-01A_TET3_chr2_74317174_+_DGUOK_chr2_74184252_length(transcript)=3102nt_BP=2634nt ATGGACTCAGGGCCAGTGTACCATGGGGACTCACGGCAGCTAAGCGCCTCAGGGGTGCCGGTCAATGGTGCTAGAGAGCCCGCTGGACCC AGTCTGCTGGGGACTGGGGGTCCTTGGCGGGTAGACCAAAAGCCCGACTGGGAGGCTGCCCCAGGCCCAGCTCATACTGCTCGCCTGGAA GATGCCCACGATCTGGTGGCCTTTTCGGCTGTGGCCGAAGCTGTGTCCTCTTATGGGGCCCTTAGCACCCGGCTCTATGAAACCTTCAAC CGTGAGATGAGTCGTGAGGCTGGGAACAACAGCAGGGGACCCCGGCCAGGGCCTGAGGGCTGCTCTGCTGGCAGCGAAGACCTTGACACA CTGCAGACGGCCCTGGCCCTCGCGCGGCATGGTATGAAACCACCCAACTGCAACTGCGATGGCCCAGAATGCCCTGACTACCTCGAGTGG CTGGAGGGGAAGATCAAGTCTGTGGTCATGGAAGGAGGGGAGGAGCGGCCCAGGCTCCCAGGGCCTCTGCCTCCTGGTGAGGCCGGCCTC CCAGCACCAAGCACCAGGCCACTCCTCAGCTCAGAGGTGCCCCAGATCTCTCCCCAAGAGGGCCTGCCCCTGTCCCAGAGTGCCCTGAGC ATTGCCAAGGAAAAAAACATCAGCTTGCAGACCGCCATTGCCATTGAGGCCCTCACACAGCTCTCCTCTGCCCTCCCGCAGCCTTCTCAT TCCACCCCCCAGGCTTCTTGCCCCCTTCCTGAGGCCTTGTCACCTCCTGCCCCTTTCAGATCTCCCCAGTCTTACCTCCGGGCTCCCTCA TGGCCTGTGGTTCCTCCTGAAGAGCACTCATCTTTTGCTCCTGATAGCTCTGCCTTCCCTCCAGCAACTCCTAGAACTGAGTTCCCTGAA GCCTGGGGCACTGACACCCCTCCAGCAACGCCCCGGAGCTCCTGGCCCATGCCTCGCCCAAGCCCCGATCCCATGGCTGAACTGGAGCAG TTGTTGGGCAGCGCCAGTGATTACATCCAGTCAGTATTCAAGCGGCCTGAGGCCCTGCCTACCAAGCCCAAGGTCAAGGTGGAGGCACCC TCTTCCTCCCCGGCCCCGGCCCCATCCCCTGTACTTCAGAGGGAGGCTCCCACGCCATCCTCGGAGCCCGACACCCACCAGAAGGCCCAG ACCGCCCTGCAGCAGCACCTCCACCACAAGCGCAGCCTCTTCCTAGAACAGGTGCACGACACCTCCTTCCCTGCTCCTTCAGAGCCTTCT GCTCCTGGCTGGTGGCCCCCACCAAGTTCACCTGTCCCACGGCTTCCAGACAGACCACCCAAGGAGAAGAAGAAGAAGCTCCCAACACCA GCTGGAGGTCCCGTGGGAACGGAGAAAGCTGCCCCTGGGATCAAGCCCAGTGTCCGAAAGCCCATTCAGATCAAGAAGTCCAGGCCCCGG GAAGCACAGCCCCTCTTCCCACCTGTCCGACAGATTGTCCTGGAAGGGCTTAGGTCCCCAGCCTCCCAGGAAGTGCAGGCTCATCCACCG GCCCCTCTGCCTGCCTCACAGGGCTCTGCTGTGCCCCTGCCCCCAGAACCTTCTCTTGCGCTATTTGCACCTAGTCCCTCCAGGGACAGC CTGCTGCCCCCTACTCAGGAAATGAGGTCCCCCAGCCCCATGACAGCCTTGCAGCCAGGCTCCACTGGCCCTCTTCCCCCTGCCGATGAC AAGCTGGAAGAGCTCATCCGGCAGTTTGAGGCTGAATTTGGAGATAGCTTTGGGCTTCCCGGCCCCCCTTCTGTGCCCATTCAGGACCCC GAGAACCAGCAAACATGTCTCCCAGCCCCTGAGAGCCCCTTTGCTACCCGTTCCCCCAAGCAAATCAAGATTGAGTCTTCGGGGGCTGTG ACTGTGCTCTCAACCACCTGCTTCCATTCAGAGGAGGGAGGACAGGAGGCCACACCCACCAAGGCTGAGAACCCACTCACACCCACCCTC AGTGGCTTCTTGGAGTCACCTCTTAAGTACCTGGACACACCCACCAAGAGTCTGCTGGACACACCTGCCAAGAGAGCCCAGGCCGAGTTC CCCACCTGCGATTGCGTCGAACAAATAGTGGAGAAAGATGAAGGTCCATATTATACTCACTTGGGATCTGGCCCCACGGTCGCCTCTATC CGGGAACTCATGGAGGAGCGGTATGGAGAGAAGGGGAAAGCCATCCGGATCGAGAAGGTCATCTACACGGGGAAGGAGGGAAAGAGCTCC CGCGGTTGCCCCATTGCAAAGTGGGTGATCCGCAGGCACACGCTGGAGGAGAAGCTACTCTGCCTGGTGCGGCACCGGGCAGGCCACCAC TGCCAGAACGCTGTGATCGTCATCCTCATCCTGGCCTGGGAGGGCATTCCCCGTAGCCTCGGAGACACCCTCTACCAGGAGCTCACCGAC ACCCTCCGGAAGTATGGGAACCCCACCAGCCGGAGATGCGGCCTCAACGATGACCGGACCTGCGCTTGCCAAGGCAAAGACCCCAACACC TGTGGTGCCTCCTTCTCCTTTGGTTGTTCCTGGAGCATGTACTTCAACGGCTGCAAGTATGCTCGGAGCAAGACACCTCGCAAGTTCCGC CTCGCAGGGGACAATCCCAAAGAGGTTTGTTTGAAGAGACTGTACCAGAGGGCCAGGGAGGAGGAGAAAGGAATTGAGCTGGCCTATCTA GAGCAGCTGCATGGCCAACACGAAGCCTGGCTTATTCACAAGACAACGAAGCTCCACTTTGAGGCTCTGATGAACATTCCAGTGCTGGTG TTGGATGTCAATGATGATTTTTCTGAGGAAGTAACCAAACAAGAAGACCTCATGAGAGAGGTAAACACCTTTGTAAAGAATCTGTAACCA ATACCATGAAGTTCAGGCTGTGATCTGGGCTCCCTGACTTTCTGAAGCTAGAAAAATGTTGTGTCTCCCAACCACCTTTCCATCCCCAGC CCCTCTCATCCCTGGAGCACTCTGCCGCTCAAGAGCTGGTTTGTTAATTATTGTTAGACTTTGCCATTGTTTTCTTTTGTACCTGAAGCA >In-frame_ENST00000409262_ENST00000264093_TCGA-BH-A0BZ-01A_TET3_chr2_74317174_+_DGUOK_chr2_74184252_length(amino acids)=958AA_start in transcript=0_stop in transcript=2876 MDSGPVYHGDSRQLSASGVPVNGAREPAGPSLLGTGGPWRVDQKPDWEAAPGPAHTARLEDAHDLVAFSAVAEAVSSYGALSTRLYETFN REMSREAGNNSRGPRPGPEGCSAGSEDLDTLQTALALARHGMKPPNCNCDGPECPDYLEWLEGKIKSVVMEGGEERPRLPGPLPPGEAGL PAPSTRPLLSSEVPQISPQEGLPLSQSALSIAKEKNISLQTAIAIEALTQLSSALPQPSHSTPQASCPLPEALSPPAPFRSPQSYLRAPS WPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEAP SSSPAPAPSPVLQREAPTPSSEPDTHQKAQTALQQHLHHKRSLFLEQVHDTSFPAPSEPSAPGWWPPPSSPVPRLPDRPPKEKKKKLPTP AGGPVGTEKAAPGIKPSVRKPIQIKKSRPREAQPLFPPVRQIVLEGLRSPASQEVQAHPPAPLPASQGSAVPLPPEPSLALFAPSPSRDS LLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPIQDPENQQTCLPAPESPFATRSPKQIKIESSGAV TVLSTTCFHSEEGGQEATPTKAENPLTPTLSGFLESPLKYLDTPTKSLLDTPAKRAQAEFPTCDCVEQIVEKDEGPYYTHLGSGPTVASI RELMEERYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCLVRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTD TLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWSMYFNGCKYARSKTPRKFRLAGDNPKEVCLKRLYQRAREEEKGIELAYL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for TET3-DGUOK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | TET3 | chr2:74317174 | chr2:74184252 | ENST00000409262 | + | 5 | 9 | 985_998 | 878.0 | 1661.0 | DNA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for TET3-DGUOK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for TET3-DGUOK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TET3 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
| Tgene | DGUOK | C3151513 | MITOCHONDRIAL DNA DEPLETION SYNDROME 3 (HEPATOCEREBRAL TYPE) | 5 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Tgene | DGUOK | C4310735 | PORTAL HYPERTENSION, NONCIRRHOTIC | 3 | GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Tgene | DGUOK | C4310935 | MITOCHONDRIAL DNA DEPLETION SYNDROME 3 | 2 | GENOMICS_ENGLAND |
| Tgene | DGUOK | C0008370 | Cholestasis | 1 | GENOMICS_ENGLAND |
| Tgene | DGUOK | C3711385 | Deoxyguanosine Kinase Deficiency | 1 | CTD_human |
| Tgene | DGUOK | C4310733 | PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS, AUTOSOMAL RECESSIVE 4 | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
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