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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TF-CCT5 (FusionGDB2 ID:89626)

Fusion Gene Summary for TF-CCT5

check button Fusion gene summary
Fusion gene informationFusion gene name: TF-CCT5
Fusion gene ID: 89626
HgeneTgene
Gene symbol

TF

CCT5

Gene ID

7018

22948

Gene nametransferrinchaperonin containing TCP1 subunit 5
SynonymsHEL-S-71p|PRO1557|PRO2086|TFQTL1CCT-epsilon|CCTE|HEL-S-69|PNAS-102|TCP-1-epsilon
Cytomap

3q22.1

5p15.2

Type of geneprotein-codingprotein-coding
Descriptionserotransferrinbeta-1 metal-binding globulinepididymis secretory sperm binding protein Li 71psiderophilinT-complex protein 1 subunit epsilonchaperonin containing TCP1, subunit 5 (epsilon)epididymis secretory protein Li 69
Modification date2020031320200313
UniProtAcc.

P48643

Ensembl transtripts involved in fusion geneENST00000402696, ENST00000264998, 
ENST00000475382, 		ENST00000280326, 
ENST00000503026, ENST00000515390, 
ENST00000515676, ENST00000506600, 
Fusion gene scores* DoF score22 X 26 X 5=286058 X 14 X 17=13804
# samples 2861
** MAII scorelog2(28/2860*10)=-3.35251641472079
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(61/13804*10)=-4.50013332598527
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TF [Title/Abstract] AND CCT5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTF(133497635)-CCT5(10250033), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTF

GO:0048260

positive regulation of receptor-mediated endocytosis

12704209


check buttonFusion gene breakpoints across TF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CCT5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-G3-A6UC-01ATFchr3

133497635

-CCT5chr5

10250033

+


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Fusion Gene ORF analysis for TF-CCT5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000402696ENST00000280326TFchr3

133497635

-CCT5chr5

10250033

+
3UTR-intronENST00000402696ENST00000503026TFchr3

133497635

-CCT5chr5

10250033

+
3UTR-intronENST00000402696ENST00000515390TFchr3

133497635

-CCT5chr5

10250033

+
3UTR-intronENST00000402696ENST00000515676TFchr3

133497635

-CCT5chr5

10250033

+
3UTR-intronENST00000402696ENST00000506600TFchr3

133497635

-CCT5chr5

10250033

+
In-frameENST00000264998ENST00000280326TFchr3

133497635

-CCT5chr5

10250033

+
5CDS-intronENST00000264998ENST00000503026TFchr3

133497635

-CCT5chr5

10250033

+
5CDS-intronENST00000264998ENST00000515390TFchr3

133497635

-CCT5chr5

10250033

+
5CDS-intronENST00000264998ENST00000515676TFchr3

133497635

-CCT5chr5

10250033

+
5CDS-intronENST00000264998ENST00000506600TFchr3

133497635

-CCT5chr5

10250033

+
intron-3CDSENST00000475382ENST00000280326TFchr3

133497635

-CCT5chr5

10250033

+
intron-intronENST00000475382ENST00000503026TFchr3

133497635

-CCT5chr5

10250033

+
intron-intronENST00000475382ENST00000515390TFchr3

133497635

-CCT5chr5

10250033

+
intron-intronENST00000475382ENST00000515676TFchr3

133497635

-CCT5chr5

10250033

+
intron-intronENST00000475382ENST00000506600TFchr3

133497635

-CCT5chr5

10250033

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264998TFchr3133497635-ENST00000280326CCT5chr510250033+581821431151971618

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264998ENST00000280326TFchr3133497635-CCT5chr510250033+0.0011553130.9988446

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Fusion Genomic Features for TF-CCT5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TF-CCT5


check button Go to

FGviewer for the breakpoints of chr3:133497635-chr5:10250033

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CCT5

P48643

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTFchr3:133497635chr5:10250033ENST00000402696-11725_3470699.0DomainTransferrin-like 1
HgeneTFchr3:133497635chr5:10250033ENST00000402696-117361_6830699.0DomainTransferrin-like 2


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Fusion Gene Sequence for TF-CCT5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000264998_ENST00000280326_TCGA-G3-A6UC-01A_TF_chr3_133497635_-_CCT5_chr5_10250033_length(transcript)=5818nt_BP=2143nt
ACAGAAGCGAGTCCGACTGTGCTCGCTGCTCAGCGCCGCACCCGGAAGATGAGGCTCGCCGTGGGAGCCCTGCTGGTCTGCGCCGTCCTG
GGCAAACGAAGCGGATGCTGTGACACTGGATGCAGGTTTGGTGTATGATGCTTACCTGGCTCCCAATAACCTGAAGCCTGTGGTGGCAGA
GTTCTATGGGTCAAAAGAGGATCCACAGACTTTCTATTATGCTGTTGCTGTGGTGAAGAAGGATAGTGGCTTCCAGATGAACCAGCTTCG
AGGCAAGAAGTCCTGCCACACGGGTCTAGGCAGGTCCGCTGGGTGGAACATCCCCATAGGCTTACTTTACTGTGACTTACCTGAGCCACG
TAAACCTCTTGAGAAAGCAGTGGCCAATTTCTTCTCGGGCAGCTGTGCCCCTTGTGCGGATGGGACGGACTTCCCCCAGCTGTGTCAACT
GTGTCCAGGGTGTGGCTGCTCCACCCTTAACCAATACTTCGGCTACTCGGGAGCCTTCAAGTGTCTGAAGGATGGTGCTGGGGATGTGGC
CTTTGTCAAGCACTCGACTATATTTGAGAACTTGGCAAACAAGGCTGACAGGGACCAGTATGAGCTGCTTTGCCTGGACAACACCCGGAA
GCCGGTAGATGAATACAAGGACTGCCACTTGGCCCAGGTCCCTTCTCATACCGTCGTGGCCCGAAGTATGGGCGGCAAGGAGGACTTGAT
CTGGGAGCTTCTCAACCAGGCCCAGGAACATTTTGGCAAAGACAAATCAAAAGAATTCCAACTATTCAGCTCTCCTCATGGGAAGGACCT
GCTGTTTAAGGACTCTGCCCACGGGTTTTTAAAAGTCCCCCCCAGGATGGATGCCAAGATGTACCTGGGCTATGAGTATGTCACTGCCAT
CCGGAATCTACGGGAAGGCACATGCCCAGAAGCCCCAACAGATGAATGCAAGCCTGTGAAGTGGTGTGCGCTGAGCCACCACGAGAGGCT
CAAGTGTGATGAGTGGAGTGTTAACAGTGTAGGGAAAATAGAGTGTGTATCAGCAGAGACCACCGAAGACTGCATCGCCAAGATCATGAA
TGGAGAAGCTGATGCCATGAGCTTGGATGGAGGGTTTGTCTACATAGCGGGCAAGTGTGGTCTGGTGCCTGTCTTGGCAGAAAACTACAA
TAAGAGCGATAATTGTGAGGATACACCAGAGGCAGGGTATTTTGCTATAGCAGTGGTGAAGAAATCAGCTTCTGACCTCACCTGGGACAA
TCTGAAAGGCAAGAAGTCCTGCCATACGGCAGTTGGCAGAACCGCTGGCTGGAACATCCCCATGGGCCTGCTCTACAATAAGATCAACCA
CTGCAGATTTGATGAATTTTTCAGTGAAGGTTGTGCCCCTGGGTCTAAGAAAGACTCCAGTCTCTGTAAGCTGTGTATGGGCTCAGGCCT
AAACCTGTGTGAACCCAACAACAAAGAGGGATACTACGGCTACACAGGCGCTTTCAGGTGTCTGGTTGAGAAGGGAGATGTGGCCTTTGT
GAAACACCAGACTGTCCCACAGAACACTGGGGGAAAAAACCCTGATCCATGGGCTAAGAATCTGAATGAAAAAGACTATGAGTTGCTGTG
CCTTGATGGTACCAGGAAACCTGTGGAGGAGTATGCGAACTGCCACCTGGCCAGAGCCCCGAATCACGCTGTGGTCACACGGAAAGATAA
GGAAGCTTGCGTCCACAAGATATTACGTCAACAGCAGCACCTATTTGGAAGCAACGTAACTGACTGCTCGGGCAACTTTTGTTTGTTCCG
GTCGGAAACCAAGGACCTTCTGTTCAGAGATGACACAGTATGTTTGGCCAAACTTCATGACAGAAACACATATGAAAAATACTTAGGAGA
AGAATATGTCAAGGCTGTTGGTAACCTGAGAAAATGCTCCACCTCATCACTCCTGGAAGCCTGCACTTTCCGTAGACCTTAAAATCTCAG
AGGTAGGGCTGCCACCAAGGTGAAGATGGGAACGCAGATGATCCATGAGTTTGCCCTGGTTTCACTGGCCCAAGTGGTTTGTGCTAACCA
CGTCTGTCTTCACAGCTCTGTGTTGCCATGTGTGCTGAACAAAAAATAAAAATTATTATTGATTTTATATTTCAAAAAAAAAAAAAACCG
GAAATGGGTCCTACCATCTTCTCGGAGCCGGAGTGCGAAGAAATAAAGAAATAGTGCTTTAAGTCAATGAATTCCTCCTTGGGACCCACT
ATCGAGAAACTATCAGTGGTAACGTTTTAAAAAATGACAAATTCAATCTGCTCTTGACTTGTGTGTCCTAAGATTTCCACTAAGTGTCTT
CAAACCTCCCCCTCCCCGGCTTCCTGGATAATAGAAGTTCCCGAAGGCCGCCGATTCCAGAAGATACTGTCTGGCGTGAAATTAGTCTCA
GTAGAAACATAAGTCCCGCGCGTCTTGTGCTGCGCGTGCGCAAGCTTTTGGGCCCTCCCGAGAAAGGGAAGTGCATTCTCGCTTCCGTAG
CGGTCTCCGCCGGTTGGGGGGAAGTAATTCCGGTTGTTGCACCATGGCGTCCATGGGGACCCTCGCCTTCGATGAATATGGGCGCCCTTT
CCTCATCATCAAGGATCAGGACCGCAAGTCCCGTCTTATGGGACTTGAGGCCCTCAAGTCTCATATAATGGCAGCAAAGGCTGTAGCAAA
TACAATGAGAACATCACTTGGACCAAATGGGCTTGATAAGATGATGGTGGATAAGGATGGAGATGTGACTGTAACTAATGATGGGGCCAC
CATCTTAAGCATGATGGATGTTGATCATCAGATTGCCAAGCTGATGGTGGAACTGTCCAAGTCTCAGGATGATGAAATTGGAGATGGAAC
CACAGGAGTGGTTGTCCTGGCTGGTGCCTTGTTAGAAGAAGCGGAGCAATTGCTAGACCGAGGCATTCACCCAATCAGAATAGCCGATGG
CTATGAGCAGGCTGCTCGTGTTGCTATTGAACACCTGGACAAGATCAGCGATAGCGTCCTTGTTGACATAAAGGACACCGAACCCCTGAT
TCAGACAGCAAAAACCACGCTGGGCTCCAAAGTGGTCAACAGTTGTCACCGACAGATGGCTGAGATTGCTGTGAATGCCGTCCTCACTGT
AGCAGATATGGAGCGGAGAGACGTTGACTTTGAGCTTATCAAAGTAGAAGGCAAAGTGGGCGGCAGGCTGGAGGACACTAAACTGATTAA
GGGCGTGATTGTGGACAAGGATTTCAGTCACCCACAGATGCCAAAAAAAGTGGAAGATGCGAAGATTGCAATTCTCACATGTCCATTTGA
ACCACCCAAACCAAAAACAAAGCATAAGCTGGATGTGACCTCTGTCGAAGATTATAAAGCCCTTCAGAAATACGAAAAGGAGAAATTTGA
AGAGATGATTCAACAAATTAAAGAGACTGGTGCTAACCTAGCAATTTGTCAGTGGGGCTTTGATGATGAAGCAAATCACTTACTTCTTCA
GAACAACTTGCCTGCGGTTCGCTGGGTAGGAGGACCTGAAATTGAGCTGATTGCCATCGCAACAGGAGGGCGGATCGTCCCCAGGTTCTC
AGAGCTCACAGCCGAGAAGCTGGGCTTTGCTGGTCTTGTACAGGAGATCTCATTTGGGACAACTAAGGATAAAATGCTGGTCATCGAGCA
GTGTAAGAACTCCAGAGCTGTAACCATTTTTATTAGAGGAGGAAATAAGATGATCATTGAGGAGGCGAAACGATCCCTTCACGATGCTTT
GTGTGTCATCCGGAACCTCATCCGCGATAATCGTGTGGTGTATGGAGGAGGGGCTGCTGAGATATCCTGTGCCCTGGCAGTTAGCCAAGA
GGCGGATAAGTGCCCCACCTTAGAACAGTATGCCATGAGAGCGTTTGCCGACGCACTGGAGGTCATCCCCATGGCCCTCTCTGAAAACAG
TGGCATGAATCCCATCCAGACTATGACCGAAGTCCGAGCCAGACAGGTGAAGGAGATGAACCCTGCTCTTGGCATCGACTGTTTGCACAA
GGGGACAAATGATATGAAGCAACAGCATGTCATAGAAACCTTGATTGGCAAAAAGCAACAGATATCTCTTGCAACACAAATGGTTAGAAT
GATTTTGAAGATTGATGACATTCGTAAGCCTGGAGAATCTGAAGAATGAAGACATTGAGAAAACTATGTAGCAAGATCCACTTCTGTGAT
TAAGTAAATGGATGTCTCGTGATGCATCTACAGTTATTTATTGTTACATCCTTTTCCAGACACTGTAGATGCTATAATAAAAATAGCTGT
TTGGTAACCATAGTTTCACTTGTTCAAAGCTGTGTAATCGTGGGGGTACCATCTCAACTGCTTTTGTATTCATTGTATTAAAAGAATCTG
TTTAAACAACCTTTATCTTCTCTTCGGGTTTAAGAAACGTTTATTGTAACAGTAATTAAATGCTGCCTTAATTGAAGGGGTTTGGGTGGA
TTTTTTTTTCTCAAAATAAGCTGTAGGGACTATTTTAACAGCTTAAACAGGAGCTCTCAAGATGCACTTTCATATTGAGAGGAATATGGG
CTTGATCCTCTTCCTATCTAAATGGGTGGGCCATTTGATTGTAGAGGGTCCACCACAGAATTATGGGATGCCTTAAGTGCTGTTACTAGG
TTGCTCACAGCCTAACCTGGCGTGTTGTTTAGGGCTGATGGAGACCCATGTGAGCCTTTGCTTTCCTCTGGCCCCGGCCCCACCCTGAAC
ACAGCTCATACACAGAATCAGGACCAGCATGTGCAGAGCTGGCCACCAGCACAGGCTTAGGGCAGTTCAGAACCCACTTGTTTCCCTATC
AGAGGGACACAGTGAAGTGGAGGTTAAAGTAAATTACAGGAAATAAGGGAGAAATCTTGCAGTTACCATGTTCAGATAGAGTGACTGAAA
TTAATTGTACTTACTAAAGTATTAACTAGCTAACAGTGATGGGCCAAGACGCTCCGAGAACTCTACCGGGATTGTCTGTTCTGACAACCC
AGTGAGGCAGATACACTTTCTTACTGCTCACATCTTACAGGTGAGTACTCATAATTGGCCAGCATCTCACCACCAGCAAGTAGTAGGGCC
AGGTCAATCCCAGGCAGTCTGACCCCAGAGTGGCCCAGCTCATCCCCTACTCTGTTATTTGCTTGTTAATGATTCTCTAGATTTTCTAAA
ATAATGTTTCTTAGCATTGTGATGATAAAGCTCATGATGAACTTTATCACTAGTTATGCCACCTTAACTAGTCAGATTTCCTAGAATTAG
GAAATGGTGACTCTTGTCTAAATTTGGTTAAGTGATGAATTTGGGTTACCGTCTCATGTGAACCTGGAGATTCACCAGTCTTAACTTTTG
GGTCATTGTGTTTTCTCTACATTCATGCATTGGATGTTTTGCTAAATAACTCCTGTGGATTTAGGAATGTGTGCTAATAGCAATCTTCCT
AATTTTCATGTTTATATGGAACTATGCAGTTGAGTATTGAAAGCTTTAAACTGAGTTTATTTACAAGGACTGAGTCTAGCCTACAGAGAA
CATACAGCAGCCTTCTTTGGACCACAGTCTTATCCGAGGGGTCTGTGGTTGTATCAGAAGAGCCACTAAACCAATCCCCCTTTCCAAAAT
TGAACCTCACAGACGTTCCTGTTTTTTGTGATTGAGAAACTGGTCAATGAACAGGAAGACTTAGAGATGTTTCACAAGCCTTTGATTTTT

>In-frame_ENST00000264998_ENST00000280326_TCGA-G3-A6UC-01A_TF_chr3_133497635_-_CCT5_chr5_10250033_length(amino acids)=618AA_start in transcript=115_stop in transcript=1971
MDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVVKKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVA
NFFSGSCAPCADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRDQYELLCLDNTRKPVDEYKDC
HLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKEFQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYLGYEYVTAIRNLREGTC
PEAPTDECKPVKWCALSHHERLKCDEWSVNSVGKIECVSAETTEDCIAKIMNGEADAMSLDGGFVYIAGKCGLVPVLAENYNKSDNCEDT
PEAGYFAIAVVKKSASDLTWDNLKGKKSCHTAVGRTAGWNIPMGLLYNKINHCRFDEFFSEGCAPGSKKDSSLCKLCMGSGLNLCEPNNK
EGYYGYTGAFRCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLARAPNHAVVTRKDKEACVHKIL

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Fusion Gene PPI Analysis for TF-CCT5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TF-CCT5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TF-CCT5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTFC0521802Congenital atransferrinemia5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneTFC0036341Schizophrenia3PSYGENET
HgeneTFC0001956Alcohol Use Disorder2CTD_human
HgeneTFC0001973Alcoholic Intoxication, Chronic2CTD_human
HgeneTFC0002395Alzheimer's Disease2CTD_human
HgeneTFC0007097Carcinoma2CTD_human
HgeneTFC0011265Presenile dementia2CTD_human
HgeneTFC0015695Fatty Liver2CTD_human
HgeneTFC0024667Animal Mammary Neoplasms2CTD_human
HgeneTFC0024668Mammary Neoplasms, Experimental2CTD_human
HgeneTFC0085762Alcohol abuse2CTD_human
HgeneTFC0205696Anaplastic carcinoma2CTD_human
HgeneTFC0205697Carcinoma, Spindle-Cell2CTD_human
HgeneTFC0205698Undifferentiated carcinoma2CTD_human
HgeneTFC0205699Carcinomatosis2CTD_human
HgeneTFC0276496Familial Alzheimer Disease (FAD)2CTD_human
HgeneTFC0494463Alzheimer Disease, Late Onset2CTD_human
HgeneTFC0546126Acute Confusional Senile Dementia2CTD_human
HgeneTFC0750900Alzheimer's Disease, Focal Onset2CTD_human
HgeneTFC0750901Alzheimer Disease, Early Onset2CTD_human
HgeneTFC1257925Mammary Carcinoma, Animal2CTD_human
HgeneTFC2711227Steatohepatitis2CTD_human
HgeneTFC0004352Autistic Disorder1CTD_human
HgeneTFC0013221Drug toxicity1CTD_human
HgeneTFC0013502Echinococcosis1CTD_human
HgeneTFC0019158Hepatitis1CTD_human
HgeneTFC0019193Hepatitis, Toxic1CTD_human
HgeneTFC0021368Inflammation1CTD_human
HgeneTFC0022660Kidney Failure, Acute1CTD_human
HgeneTFC0027626Neoplasm Invasiveness1CTD_human
HgeneTFC0027726Nephrotic Syndrome1CTD_human
HgeneTFC0028754Obesity1CTD_human
HgeneTFC0030524Paratuberculosis1CTD_human
HgeneTFC0035258Restless Legs Syndrome1CTD_human
HgeneTFC0041755Adverse reaction to drug1CTD_human
HgeneTFC0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneTFC0271901Microcytic hypochromic anemia (disorder)1CTD_human
HgeneTFC0282193Iron Overload1CTD_human
HgeneTFC0345967Malignant mesothelioma1CTD_human
HgeneTFC0860207Drug-Induced Liver Disease1CTD_human
HgeneTFC1262760Hepatitis, Drug-Induced1CTD_human
HgeneTFC1565662Acute Kidney Insufficiency1CTD_human
HgeneTFC2609414Acute kidney injury1CTD_human
HgeneTFC3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneTFC4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneTFC4279912Chemically-Induced Liver Toxicity1CTD_human
HgeneTFC4553297Cystic Echinocccosis1CTD_human
TgeneCCT5C1850395Neuropathy, Hereditary Sensory, with Spastic Paraplegia, Autosomal Recessive3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneCCT5C0006142Malignant neoplasm of breast1CTD_human
TgeneCCT5C0019193Hepatitis, Toxic1CTD_human
TgeneCCT5C0019693HIV Infections1CTD_human
TgeneCCT5C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneCCT5C0678222Breast Carcinoma1CTD_human
TgeneCCT5C0860207Drug-Induced Liver Disease1CTD_human
TgeneCCT5C1257931Mammary Neoplasms, Human1CTD_human
TgeneCCT5C1262760Hepatitis, Drug-Induced1CTD_human
TgeneCCT5C1458155Mammary Neoplasms1CTD_human
TgeneCCT5C3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneCCT5C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneCCT5C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneCCT5C4505456HIV Coinfection1CTD_human
TgeneCCT5C4704874Mammary Carcinoma, Human1CTD_human