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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TFRC-UBXN7 (FusionGDB2 ID:89781)

Fusion Gene Summary for TFRC-UBXN7

Fusion gene summary

Fusion gene information	Fusion gene name: TFRC-UBXN7
	Fusion gene ID: 89781
		Hgene	Tgene
	Gene symbol	TFRC	UBXN7
	Gene ID	7037	26043
	Gene name	transferrin receptor	UBX domain protein 7
	Synonyms	CD71\|IMD46\|T9\|TFR\|TFR1\|TR\|TRFR\|p90	UBXD7
	Cytomap	3q29	3q29
	Type of gene	protein-coding	protein-coding
	Description	transferrin receptor protein 1	UBX domain-containing protein 7UBX domain containing 7
	Modification date	20200313	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000420415, ENST00000360110, ENST00000540528, ENST00000392396, ENST00000535031, ENST00000465288,	ENST00000296328, ENST00000428095, ENST00000535858,
Fusion gene scores	* DoF score	11 X 12 X 8=1056	8 X 8 X 4=256
	# samples	15	8
	** MAII score	log2(15/1056*10)=-2.81557542886257 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/256*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TFRC [Title/Abstract] AND UBXN7 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TFRC(195796326)-UBXN7(196089558), # samples:1
Anticipated loss of major functional domain due to fusion event.	TFRC-UBXN7 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. TFRC-UBXN7 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TFRC	GO:0006826	iron ion transport	7556058
Hgene	TFRC	GO:0030890	positive regulation of B cell proliferation	26642240
Hgene	TFRC	GO:0031623	receptor internalization	26642240
Hgene	TFRC	GO:0033572	transferrin transport	26642240
Hgene	TFRC	GO:0035690	cellular response to drug	16254249
Hgene	TFRC	GO:0042102	positive regulation of T cell proliferation	26642240
Hgene	TFRC	GO:0045830	positive regulation of isotype switching	26642240

Fusion gene breakpoints across TFRC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UBXN7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-13-1511-01A	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-

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Fusion Gene ORF analysis for TFRC-UBXN7

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000420415	ENST00000296328	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-
Frame-shift	ENST00000420415	ENST00000428095	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-
Frame-shift	ENST00000420415	ENST00000535858	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-
In-frame	ENST00000360110	ENST00000296328	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-
In-frame	ENST00000360110	ENST00000428095	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-
In-frame	ENST00000360110	ENST00000535858	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-
3UTR-3CDS	ENST00000540528	ENST00000296328	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-
3UTR-3CDS	ENST00000540528	ENST00000428095	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-
3UTR-3CDS	ENST00000540528	ENST00000535858	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-
Frame-shift	ENST00000392396	ENST00000296328	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-
Frame-shift	ENST00000392396	ENST00000428095	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-
Frame-shift	ENST00000392396	ENST00000535858	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-
5UTR-3CDS	ENST00000535031	ENST00000296328	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-
5UTR-3CDS	ENST00000535031	ENST00000428095	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-
5UTR-3CDS	ENST00000535031	ENST00000535858	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-
intron-3CDS	ENST00000465288	ENST00000296328	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-
intron-3CDS	ENST00000465288	ENST00000428095	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-
intron-3CDS	ENST00000465288	ENST00000535858	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000360110	TFRC	chr3	195796326	-	ENST00000296328	UBXN7	chr3	196089558	-	10630	971	170	1606	478
ENST00000360110	TFRC	chr3	195796326	-	ENST00000428095	UBXN7	chr3	196089558	-	1674	971	170	1606	478
ENST00000360110	TFRC	chr3	195796326	-	ENST00000535858	UBXN7	chr3	196089558	-	1655	971	170	1606	478

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000360110	ENST00000296328	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-	8.98E-05	0.9999101
ENST00000360110	ENST00000428095	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-	0.001217761	0.9987822
ENST00000360110	ENST00000535858	TFRC	chr3	195796326	-	UBXN7	chr3	196089558	-	0.001382164	0.9986179

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Fusion Genomic Features for TFRC-UBXN7

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TFRC-UBXN7

Go to
FGviewer for the breakpoints of chr3:195796326-chr3:196089558
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TFRC

chr3:195796326

chr3:196089558

ENST00000360110

58_61

267.0

761.0

Motif

Stop-transfer sequence

Hgene

TFRC

chr3:195796326

chr3:196089558

ENST00000392396

58_61

267.0

761.0

Motif

Stop-transfer sequence

Hgene

TFRC

chr3:195796326

chr3:196089558

ENST00000360110

68_88

267.0

761.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

TFRC

chr3:195796326

chr3:196089558

ENST00000392396

68_88

267.0

761.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

UBXN7

chr3:195796326

chr3:196089558

ENST00000296328

337_342

278.0

490.0

Compositional bias

Note=Poly-Glu

Tgene

UBXN7

chr3:195796326

chr3:196089558

ENST00000296328

285_304

278.0

490.0

Domain

Note=UIM

Tgene

UBXN7

chr3:195796326

chr3:196089558

ENST00000296328

408_485

278.0

490.0

Domain

UBX

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TFRC

chr3:195796326

chr3:196089558

ENST00000360110

223_313

267.0

761.0

Domain

Note=PA

Hgene

TFRC

chr3:195796326

chr3:196089558

ENST00000392396

223_313

267.0

761.0

Domain

Note=PA

Hgene

TFRC

chr3:195796326

chr3:196089558

ENST00000360110

646_648

267.0

761.0

Motif

Note=Cell attachment site%3B required for binding to transferrin

Hgene

TFRC

chr3:195796326

chr3:196089558

ENST00000392396

646_648

267.0

761.0

Motif

Note=Cell attachment site%3B required for binding to transferrin

Hgene

TFRC

chr3:195796326

chr3:196089558

ENST00000360110

569_760

267.0

761.0

Region

Note=Ligand-binding

Hgene

TFRC

chr3:195796326

chr3:196089558

ENST00000392396

569_760

267.0

761.0

Region

Note=Ligand-binding

Hgene

TFRC

chr3:195796326

chr3:196089558

ENST00000360110

89_760

267.0

761.0

Topological domain

Extracellular

Hgene

TFRC

chr3:195796326

chr3:196089558

ENST00000392396

89_760

267.0

761.0

Topological domain

Extracellular

Tgene

UBXN7

chr3:195796326

chr3:196089558

ENST00000296328

2_54

278.0

490.0

Domain

Note=UBA

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Fusion Gene Sequence for TFRC-UBXN7

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000360110_ENST00000296328_TCGA-13-1511-01A_TFRC_chr3_195796326_-_UBXN7_chr3_196089558_length(transcript)=10630nt_BP=971nt
CTCGCGAGCGTACGTGCCTCAGGAAGTGACGCACAGCCCCCCTGGGGGCCGGGGGCGGGGCCAGGCTATAAACCGCCGGTTAGGGGCCGC
CATCCCCTCAGAGCGTCGGGATATCGGGTGGCGGCTCGGGACGGAGGACGCGCTAGTGTTCTTCTGTGTGGCAGTTCAGAATGATGGATC
AAGCTAGATCAGCATTCTCTAACTTGTTTGGTGGAGAACCATTGTCATATACCCGGTTCAGCCTGGCTCGGCAAGTAGATGGCGATAACA
GTCATGTGGAGATGAAACTTGCTGTAGATGAAGAAGAAAATGCTGACAATAACACAAAGGCCAATGTCACAAAACCAAAAAGGTGTAGTG
GAAGTATCTGCTATGGGACTATTGCTGTGATCGTCTTTTTCTTGATTGGATTTATGATTGGCTACTTGGGCTATTGTAAAGGGGTAGAAC
CAAAAACTGAGTGTGAGAGACTGGCAGGAACCGAGTCTCCAGTGAGGGAGGAGCCAGGAGAGGACTTCCCTGCAGCACGTCGCTTATATT
GGGATGACCTGAAGAGAAAGTTGTCGGAGAAACTGGACAGCACAGACTTCACCGGCACCATCAAGCTGCTGAATGAAAATTCATATGTCC
CTCGTGAGGCTGGATCTCAAAAAGATGAAAATCTTGCGTTGTATGTTGAAAATCAATTTCGTGAATTTAAACTCAGCAAAGTCTGGCGTG
ATCAACATTTTGTTAAGATTCAGGTCAAAGACAGCGCTCAAAACTCGGTGATCATAGTTGATAAGAACGGTAGACTTGTTTACCTGGTGG
AGAATCCTGGGGGTTATGTGGCGTATAGTAAGGCTGCAACAGTTACTGGTAAACTGGTCCATGCTAATTTTGGTACTAAAAAAGATTTTG
AGGATTTATACACTCCTGTGAATGGATCTATAGTGATTGTCAGAGCAGGGAAAATCACCTTTGCAGAAAAGGAGAGCCTTATAGATGCAA
GTGAAGACAGCCAGCTAGAAGCTGCCATCAGAGCCTCCTTACAAGAAACACATTTTGATTCAACACAGACAAAACAGGATAGCCGCTCAG
ATGAAGAATCTGAATCTGAACTTTTTTCTGGCAGTGAGGAGTTCATATCCGTTTGTGGCTCTGATGAAGAAGAAGAGGTAGAGAATCTTG
CCAAGTCCAGAAAGTCTCCCCACAAAGATTTGGGGCATAGAAAAGAGGAGAATAGAAGGCCGCTGACTGAGCCACCAGTCAGAACTGATC
CTGGAACAGCCACAAACCACCAAGGATTGCCAGCTGTGGATTCAGAGATACTGGAGATGCCACCTGAAAAAGCAGATGGAGTAGTGGAGG
GGATAGATGTAAATGGACCAAAAGCACAGCTGATGTTGCGGTATCCAGATGGAAAAAGGGAACAGATCACTCTTCCAGAGCAAGCTAAAC
TGCTAGCTTTGGTGAAGCACGTGCAGTCTAAAGGATACCCAAATGAACGTTTTGAACTTCTCACCAACTTTCCTCGAAGGAAATTATCTC
ATCTGGACTATGATATTACATTGCAAGAGGCAGGCCTTTGTCCTCAAGAGACTGTCTTTGTACAGGAAAGAAATTAACACCATGGCTTGA
CCTCTCTCAGCTTACCCCTTTTTTCCCTTTTCCTGTGAGATACATGTCACTAAGTATGCATTTTGGCTCATAGGACCACAGAGCCAAAGT
TGGGCAAGCAAGTCACCTTCCTTCTCTTATTTCTTGATCTCTCCTATAATCAGTCTCTTTCTCCCCCTTTGTTTCTTTCTCCTCTTCTGT
TTTCTCGCTCCCCACTCCGTACCCTTCTGCCTCCCCCTCCCCCCACACTTTTCTTTCTTACCTAATCTGGTGACCAAACTGAAGTGTAAG
GATAAGACCTCTCCTAGTACTAGCAGCAGGAATTGTGTGTTCCAGTAAGTGGTCTCTTGCACGGCACTTTTTTGGGATCAAATGTTAACG
TTACTCCCCAGACTCTTCGGGCAAAGGAATGGCTAGATTCAGAGTAAGAACAACCCTCCCTTTTTTGTAAGTCCCCGTGTTTAGCAGGGA
GAAGAAATTCTCTAACATGGGTTTGGTTTTGTTGTGTTCTTCATGTGGAAATGTCGCTTAACAAAATATCCAGGCTTTTGTTTACGTGGA
AAAAGCATCCCTTGTAATGATTGCTCATCATACTTAAAAACCTTTTTCAAAGGATTTTCATGTTCCCAGCTATAAGGACTATTTCCATGA
CATGTGTTATTGGCAGAATGAGTGTTAAATATGGAGCATATAGCATGGGGTGACTTTCATTGTCCTAACCTGAGACAGTTTTCCTTATTA
CTCTGTATTGATCCTGCTAGTCCAAGAATGGACATGAAGTGAACCTATCGTGGTGACTGGGATAGGAAGGTGCTTGCTATTTTTGCCAGC
ACAGCATATTAGTTCCTTTGGAGCCCTCCATTGTCTGAGTCTGCAGTGATCTGTAGGAAGGCAGCTGGTCAATAATCATGTAGTACAATG
GCTTGGAATTGTAACCACTATGGTTATTGATTGTCCTGTGTTGTTTCAGGCATACTTAGGTATGTCCCTGGGGAAAAAGAAAACCATTCA
GCTGAGAGTTGCTAACCATGTTCTTTTGGTTAGAAATAATGGTTCATTTTTTGCCCCTGGTTGGAATAGTCTCTAAAAGGCTCTGGTGAC
TGAATTGAACATGAGTCCGCATGCTGTTTTCTTTCAAAAGGTATCAAAACGGAAAGCCTCTCTAAGGGGAAGACCTTTCAACTCCATTCA
GAAGACAACATTTAGTAAGGAGGATGGCGGAGGTTACTAGTAATTTTCAGATGTCTTGGGCTTTTTCTGCCAACAAAACCCAAAATCAAA
TTAGAGTTGGTGAAAGCTTTCTTCAGTGTTTTTAGAAGAGGCCATCTTGAATCTGTAGAATACCATTTACACATCAACTTCACCCTATGC
TCATTTCGTATTTTGAGCTTAAATGGAGTCCTCTGAAGGGGGGGTAGTCGTGATTCTGGTGGCAAAACTAGAACTTTTAACTTGTAAAAT
GAAAAATATTAAATGGACCTTTTTGTCAGTTGAGGATTTAGATTGATTCTTTTATCTGAGGAGCGTATGTTCCTCAGATGTTGCGTAGAG
ACCTTTAGGTTTTCATCTACTTTAAGATTGCTCTCTTGGCAATTAGGGGATTTGGGAAAAGAAGAAAAAAAGATGCCATGTGTTGCTAGT
ACACAGTTATAGGATATGGTTTCTAATGGTTGAATTTTGAGGAACTCTCCCTAAAGAATGAGTTTTATATCTCCTCAAGGAAATCATGGA
AAAATCTGTTTATTCTTCAGTGAGTCCTTTTGAATTAATGTTCTTAAATTTTTTTCTAAGTCTGTGTAAGTGCTTATGTATAAGTATATA
ATTGTATAAATATTTATAAATATATTTATATAATTACGGTTTCATTTCTACCTTGAGTCAAAGTTCTGTCTTTAGATTGGTGACTGAGTA
ATACTTACACTTTGGTGTTTTTTCTTAGGTTCTTGAGGCTTACTTAACTAGCAGCTTCTGATTTATTGAGTGAAAGATGGTTTTCATGTT
AATTCCTCAGTTGCATCTCTGAACTTGGATAACATACTTGCCGTTTGAAAAATAGAGCTGTATACTGTCAAAGGTGCACTGGAGGGTAAA
ACATTTGTTGGTAGTAGACAAGCTCAGAAATCCAAAAATTCAGGGAGGGCACAGGGTAAGAAGAGAGGTTTGCTCAGCTTTGTGCTCTGA
TGGCACCCATCTGTACTCCAGCAAAGTCATAGCTGAAGCCCAAATCGCTCAAACGTGTGAAGTCAATCATTTTTCCTATAGGGCTCTGTT
TCCTTTTCTTTACCTTCTAGCTTCTCTTGATAAAACAGTTGGGAGAACTGCCAACGTGTTCATCAGTGAGAGGGTGTGGTTCTTTCCGAT
ATGTTCAGCACGTGCATATTCATTTATGAGAAACCAAAGTAACTTCTTCAACTCGGGTTACTGTGGGATGATTAAGTAGATATAAAGTGA
TTTAAAAGACAGCATGGTACTTTCACTCAGCTTAACATGCAGCTGGGATGTCTACAATACAAGATGTGGTGGGTTTTATTTTATTTTATT
TTGAGGCAGGAGTGTAATTATCTTAGGGTTGATATAAAGGCCCATGGGAAGAGTTACGGATTGTACATGGGAAGAATCCATAAGGAGTAT
TGCCTTGCTCAAGAATTTAATCCGCTGACAGTATGCTTCTTCCAGTTTGCCTTACTTCCTCTGCAAGTTTCTTTGCTCCTTAGGGCAGAG
GTTTTATTGAATAGATTAAATGAGGTCAGTAAGATTAGTTAAAAATAGTCATTCCTTGTGGGTGTTGGACACAGCTTGAAAGGAGTGTTT
AAAAAAAAAAAGCTAGGGAGGAAAAGAACAAGAAAGATAGACTTCGAGAGTGATAAGAGAAAAATACAGGGAGATGGAATGGAAACTACC
AGGAAGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAACACTTTGGGAGGCGGAGGTGGGCAGATCACCTAAGGTCAGGAGATCGAGGC
CAGCCTGAGCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTACCTGGGTGTGGTGGCGTGCACCTGTAATCCCAGCTACTC
AGAGGCTGAGGCAGGGGAATGGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCAAGATCGCACCATTACACTCCAGCCTGGGCGACAA
AGCGACACTCCATCTCAAATTTAAAAAAAAAAAAGAAGAAGAAGAAGAAAACTAGTGGGAAAAAAGTGAGAGGAATACTTTTTTGAAATT
GGTATCGGAAGGAACTGGAGAAGAGAAAACAACAGTGCCAAATGAGAAAAGAACAGGAAACTTAATACTAATTGGCATGCACCAGATACT
TTTGTGTACATTTGCCTCTTCAATCTCCCGAAGAATCGTACAAAATGTATACTTTCTTCCCATGTTAAGAAAACAGGTATAGAGAACTTA
TTCAGGACTCATAGCTAGTGAGTGGCAAATCAGAATTGGAATCCAGAGTCCATGCTGTGGTCTCCTTCAGCAAGAGAATCAAGCTACCCA
GATGATTCTCTTCTCATTGTTTGGCTTTGTAAAGTGTCACTTAGTTTTGTTCCCATAAATATAGAGGAAGTAGTTGGGTTAAAGTTGTGG
GATTTGCACTATGCCTATACATTTTTATTTATGCCATTATTTTGAGAGGCTGATTATTGCTTTTTTAAAATGATGCACTGGTGAAGATGT
GAAAGTAAAATTGCCACGTGGCATTATTTGCCAAGAATAAATGAAAAGGGTAAAAAAACAATTTTTTCTTTTTTTAAACATTTTTCAGAA
AAGATACAATTACCTTTTTTAATAGGTGAGCGCCACCACGCCCGGCTAATTTTTGCATTTTTAGTAGAGACAGGGTTTCACCATGTTGGC
CAGGATGGTCTCGATCTCTTGATCTCGTGTTCCGCCCACCTCGGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGATC
TACAATTCTGTTTTCTGTGTCCCATCCATACCAGATTATTGAACCCTCTGTGTGTATGTTTTTAAATCTTGTATATAATTCTACTTCCTT
GACTTACAAGTCAACAATTAGCTATTGAGTTCTTTATAGAAGTTGGAAGTATTTTGAAATCTGAGATCTAATTCCTGGCCAGGTGTGGTG
GCTCATGCCTGTAATCCCAATATTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTTGGGAGTTCGAGATCAGCCTGGCCAACATGGTG
AAACCCCATCTCTACTGAAAAATACAAAAATTAGCCAGGCATGGTGGCTGTCTGTAATCCCAGCTAATGGGGAGGCTGAGGCACAAGAAT
CTCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATCACACCACTGCACTCCATCCTGGGCAATGGAGCGAGACTCTGTCTCAAAA
AATAATAAATAAGATATGATTCCTGCCTGTTTTATCCAGTTAGAGAGACACACTACACATGAAATAATTGGAGAGCATGTAAATGTTTAC
CTATTAGTTCAAACTTAGAAAAAGGGAAGAATATGTTTTAGTTAGCAAAGTCTTAAACAAGACTGAAGTGGCAAGCACTGTAGCTCACGT
TTTCTTTTGACTCACCTTTTTCTTTAGCTCCACCTTTTGTAACTTCTAGATTTGGGGCATGAAGTTCTGCCACTAAGGCATAACCAGTAC
CCAAGTAGGAAAGGATTATTGATCCCTGGAGTAAAGATTCCTAGCTTGCGGGGATCTCACTATTGATCCCCCGGAGTAAAGATTCCTAGC
TCGCAGGAATCTTACTTGCACACTTAGGGAAAATACCAGAGGGAGCCACTAGCAACCGAAAAATGAAGGAAAGATTTAATTTCTCTACCC
AGGTACAAATCCAATGCATAGTATAGTATATGTTATATGCAGAAAGGGCACTGGAGGTGTGAGAGCCCTTTGGGTAACAGCTCTGCTAGT
TGTTACCTTCACACTTCTCTTTCTTCTTAATCTCTGGTTTCTCGTCTGAAAAATGAGATAATTGGACTAGATTAATAGTTCTCAGCCTTT
TCTAGAACAACAAATTAGATTATCTCTGAAGTCCTTTTCCAAAATTTCATGCTTCCAGTCTCTCCCCGTGATTGCGTATTATCCCTAGGC
TAATTAAAAGTGTGCTGGTTAATCAGTTTCTTTACTTTTTTTTTCTCTCTTTTTTTTATTCTGTGTTCAGGTATCATTTGACCAACAACT
TGCTCTTAATCTTACTGCGATGACTGAAATCTCCAAAGAGGAGAGTATAGTAGTTATAGGTCTAGTAATAATAATCTTGTAAACAATTCA
TTATTTTTTAAAACTTAATGCTGTGTGCCTAATCAGTGTTGAGTATGACTAAAATGTAAATGAGAACCAAATATGACACTAACGCTGGCA
CTAAATTTTATTTTTACTTGTGTACTTAAAGTACTTTACTGGCCTGTTGGGAAATTGATTTGTATAAGATTCACACCTGGTTTTGGCAGA
AACAGCTTTTTAAAGATACAATTAGGCTGACTTAAAAATGTTTTTTATTCCACAGAATGTATCTTTATTATGTCATTCTTACCGTCTCTC
TGCCTTTTTTGACCATCATGTAACTACGCAGTAGTAAATCATGGGGTGCAGGCTGATGAATTAGTAGTCTTTGTAAAACTAAAATGTAAT
GAGCATAGGAAGAGACAGCTCTTCTGGTGAACATGGCAGTTTTCCGGTAATACCAGCCTTGATGAATAGGCTAAAGACAGCTGTGTACTA
TGGACATTCAACTTCACTGGATTGCCTGGCTTAGCTTTTCAGTTATTGTCTTGCCGTGAAACATGGTGTTGCACTGTACACATTTTAGAA
TAGTGGCAAGAATGTTCTTTAGAACTGCAGATAACCCAACAGAGAATACCATACCAATATATCGGTTTCTCCTGTTACATAGAGATTTGG
TATTTCAGTGATGGTTATGGTTTTTGACTCACCTGTGTGTCAGTCCTGCTAGAGAGACAGTATAGAATCAAGAATTTCTTGATGTCTTTT
TAAAAATAGAGATTATAATGGCCTTGCTAGTTGTCCTGTGAAGTGACAGACCCTTAATTAGAAATCTTTTAATCCTGCTTTCCATTTTAC
TTCTCCACCATTTATTTTTAACATTCATTCTCTGAAAATAGTTATGATTTTTAGTGTAATTGGCTATGTTTAAGAAATTCCATTTCAAAG
TCTTAATATGTAACAATCTTCATTTTTTATAAAATTGAAGGACATTTTTGAGGCAAACTTACTTTTATAGCTCATTTTCTCCCTAGTTAA
GGAGAATTCTCTGGTTTCATATAGAGAATGGCTAGCTCTGTGATACCCCACCCTCTTTGTGGCCTACCAGTTGCTGTTGTGTTGCTTAAA
ATTGCAGATATTCTCATAAACATGATGATTTTTGGCACAGGCCTTTCTTTGCTATTGATTTCAAAATAAAGTTGGGCAATCCAATTTGAA
CTACTTTAATAAACATAATTTAGCATTCCTGTAATGAGAAAGTATTTTCAAAAGATAACCAGATTTATTTCTAGGATTAGAGATGGCAAA
TACCAATGATAGTATTTTTCCCAAGAGCAATCACAGATTAATCTATAAATATGAGAAGTCGCATTATTGTACTTAATTCTTTGGCAACAA
ACAGCAAGTTTTTATTGTTTAATTGTATTTCCTCTCTAGAGATCACAATACTCTGGGTATTTTATATCCCTTCTAAAGGTCATTTGGGTT
TTCAAATGGGAAGAATAGTCAAGCTAAGCTGGACTAAACCTAAGTAATATTTTTTCTCATCAAAAGAAGTTATTAATCTAACTGGGTTAG
CATGAGTCATTCATTTTTTAGACATGATAAATGGGAAACATATCAAATCATTAGATAAATTCTGACCTGGAATTGAATTCCCCCTTTCTT
AAAATCTTTTTAATTTGCTTTTTTCATAGACTCAGTATGGAACTCTTAACTGATAAGGGAGAGATTCTTGATCTGGAACCGTTCCCTGCC
ATTCTCCTTTTTTCTCTCTATCTAGGTAGCTGGTTCCATAGTGCCCGTCACGAGGGTCCATTTCAGTTTGATGACATTAGACTGCTTACA
CTCAGCTGGATGCCTTGCTGTTTGCAGCAACATGATTTTACAGTATGCTTTTCTCAAAGCTTTGCATTCTTAATGGAGATATCAAATGGT
GTAATTCCAAATATAAATATGTTTATGACACTAATCATATGCTTTTAACAATAACTTTTTGATAACTTATTGCCCTGTAAGTTAAACCTT
ACACGGAGTGACTGTTGCCATCAGAAAATCCCCTTTCACCTGCTAGAGAGAGTGAAAGTAGTGCGTGGCCTCCACTTTTCAGTTAACGAG
TAGCAAGCTTCTAGTAGGGGCTGCTTATCTGACCCATGTGGGGTCTTGGGCCTTGTTACTTTCCTGGGTTCGTCCCTTCAGCTGGAAAGG
CTGTTGAAAACACTTGCCAGGAAACAGTAAAGCTGTGAGAGAATCTTCTAGTCTTAGATATAGAGAAATGAGTACCAGTTGATGCTAACA
CGATACTTAGACTTTGAGGGGCTTCCATCCAAGCTTTGGCATGAATCTGTTAGACACGGTTTTCTTCACTCCTCTGATAATCTTTTTTTC
CAGAATGGTTTTTTGTTGTTGTTGTTGTTAACAAATTCTAAACATCCAGTGTTACTTTTTGTTTTGTTTGTTTTGTTTTGTTTTGTTTTG
TTTTGTTTGCCCTTCAGGAAAGTCCTTTTTCGAGTAGGTATTGATTGTTCCCTGGAAACTCTCAGCAGTGTCTGTGCAGGCTCTGTGCAT
GCTTTGTATGAGTTCGGCTTGAACAATGCATTTGAAGTCACCTGGGATGTCCAGTTCTGGCATGTCTTCATTGATTGTGTTTTTAAACAT
GTTTCATGTTTCATGTCATTTTCCAAACCTCACTTTACATCTTACTCAGAGAAGTTAATCAAGGAATGAAATTTCTAGGGGGATAGGGAT
GATGAGGGTGGGTTGGGGGCTTGAGTGAAGTCAACTTGGGGTATTTGCTTTAAAGTGTTTTCTAAAGCAGTTCCTAACAGTATTTAGAGA
TTCCCTGGGATGTTTGTGGCTCAACTTATTCTGGACAAAGTGTGTGTGGGGGTGGTCTTACTGAGATTTGCATTCTTAATGCAGGACAGG
CTCTAAATTTCATCTGTACTCTAAATTTGTGATTGAATCCAAGAAGATAACAGAGACAGTGCTCCTGTTGTAATGTTTCTGGCAAGTGCT
CCCTAAAATGCACATCGAATTCTGTTTTCTGGGCCTTTTCTCCAATGGTGCTAGGAGATACCGTTGATTTCTGCAGCTCTTCTCAGTGGT
GGGAAGAAGTCTTTGGGATTGTTGAGCAAGGGGCAGCTGGACCATCCACTAAATTTTTTTGTTCAAGACACATTAGAGACCCTCCTGTAT
ATCTAGTAAGTCATAATAAAGGTGCTTGGGAAAGCCTTAAATTTGAAGACACATGGAGGCGGTAGAAAATTAAACTTGTAAGAGGAGAAA
AACATGCCATTAGGTAACGCAGAGTTGTAACTACTGGCTAAGACTCAATGGAACTTCCACTTGCTCTAAAACCAGGGAAATCTTAGATAA
CTGGGTGTGATCTACCTATAGATCTACCTAGTCTATAGGTAATAATTTCCAGAAGGAGGATCTTGCTGTCAGTTGGGGATCCTCTGGTTT
GGTCTGTACCAAATTGTGAATACTCTTGCTGTGTTGTACCCAGTTGCTTTATATTAATACTGCAACTTGAAACGGGGAGGGTGGGGGGAC
AATGGGGTGGGGGAGGGAAGGGAGTGGGACGATAAGTCTTTTGAAGACATCAGCTCACTGTGCTGAGAGAGGGACCAAACTCAAGGAAAC
CTCTGATCTATACATTCAACTGCTGCATTTTTTTATAAATACATGTAAATGTCCTGTTGTAATATTTGATCTTGGAAATAAAAACAAAAA

>In-frame_ENST00000360110_ENST00000296328_TCGA-13-1511-01A_TFRC_chr3_195796326_-_UBXN7_chr3_196089558_length(amino acids)=478AA_start in transcript=170_stop in transcript=1606
MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPKRCSGSICYGTIAVIVFFLIGFMIGYLGYCK
GVEPKTECERLAGTESPVREEPGEDFPAARRLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSK
VWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTKKDFEDLYTPVNGSIVIVRAGKITFAEKESL
IDASEDSQLEAAIRASLQETHFDSTQTKQDSRSDEESESELFSGSEEFISVCGSDEEEEVENLAKSRKSPHKDLGHRKEENRRPLTEPPV
RTDPGTATNHQGLPAVDSEILEMPPEKADGVVEGIDVNGPKAQLMLRYPDGKREQITLPEQAKLLALVKHVQSKGYPNERFELLTNFPRR

--------------------------------------------------------------
>In-frame_ENST00000360110_ENST00000428095_TCGA-13-1511-01A_TFRC_chr3_195796326_-_UBXN7_chr3_196089558_length(transcript)=1674nt_BP=971nt
CTCGCGAGCGTACGTGCCTCAGGAAGTGACGCACAGCCCCCCTGGGGGCCGGGGGCGGGGCCAGGCTATAAACCGCCGGTTAGGGGCCGC
CATCCCCTCAGAGCGTCGGGATATCGGGTGGCGGCTCGGGACGGAGGACGCGCTAGTGTTCTTCTGTGTGGCAGTTCAGAATGATGGATC
AAGCTAGATCAGCATTCTCTAACTTGTTTGGTGGAGAACCATTGTCATATACCCGGTTCAGCCTGGCTCGGCAAGTAGATGGCGATAACA
GTCATGTGGAGATGAAACTTGCTGTAGATGAAGAAGAAAATGCTGACAATAACACAAAGGCCAATGTCACAAAACCAAAAAGGTGTAGTG
GAAGTATCTGCTATGGGACTATTGCTGTGATCGTCTTTTTCTTGATTGGATTTATGATTGGCTACTTGGGCTATTGTAAAGGGGTAGAAC
CAAAAACTGAGTGTGAGAGACTGGCAGGAACCGAGTCTCCAGTGAGGGAGGAGCCAGGAGAGGACTTCCCTGCAGCACGTCGCTTATATT
GGGATGACCTGAAGAGAAAGTTGTCGGAGAAACTGGACAGCACAGACTTCACCGGCACCATCAAGCTGCTGAATGAAAATTCATATGTCC
CTCGTGAGGCTGGATCTCAAAAAGATGAAAATCTTGCGTTGTATGTTGAAAATCAATTTCGTGAATTTAAACTCAGCAAAGTCTGGCGTG
ATCAACATTTTGTTAAGATTCAGGTCAAAGACAGCGCTCAAAACTCGGTGATCATAGTTGATAAGAACGGTAGACTTGTTTACCTGGTGG
AGAATCCTGGGGGTTATGTGGCGTATAGTAAGGCTGCAACAGTTACTGGTAAACTGGTCCATGCTAATTTTGGTACTAAAAAAGATTTTG
AGGATTTATACACTCCTGTGAATGGATCTATAGTGATTGTCAGAGCAGGGAAAATCACCTTTGCAGAAAAGGAGAGCCTTATAGATGCAA
GTGAAGACAGCCAGCTAGAAGCTGCCATCAGAGCCTCCTTACAAGAAACACATTTTGATTCAACACAGACAAAACAGGATAGCCGCTCAG
ATGAAGAATCTGAATCTGAACTTTTTTCTGGCAGTGAGGAGTTCATATCCGTTTGTGGCTCTGATGAAGAAGAAGAGGTAGAGAATCTTG
CCAAGTCCAGAAAGTCTCCCCACAAAGATTTGGGGCATAGAAAAGAGGAGAATAGAAGGCCGCTGACTGAGCCACCAGTCAGAACTGATC
CTGGAACAGCCACAAACCACCAAGGATTGCCAGCTGTGGATTCAGAGATACTGGAGATGCCACCTGAAAAAGCAGATGGAGTAGTGGAGG
GGATAGATGTAAATGGACCAAAAGCACAGCTGATGTTGCGGTATCCAGATGGAAAAAGGGAACAGATCACTCTTCCAGAGCAAGCTAAAC
TGCTAGCTTTGGTGAAGCACGTGCAGTCTAAAGGATACCCAAATGAACGTTTTGAACTTCTCACCAACTTTCCTCGAAGGAAATTATCTC
ATCTGGACTATGATATTACATTGCAAGAGGCAGGCCTTTGTCCTCAAGAGACTGTCTTTGTACAGGAAAGAAATTAACACCATGGCTTGA

>In-frame_ENST00000360110_ENST00000428095_TCGA-13-1511-01A_TFRC_chr3_195796326_-_UBXN7_chr3_196089558_length(amino acids)=478AA_start in transcript=170_stop in transcript=1606
MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPKRCSGSICYGTIAVIVFFLIGFMIGYLGYCK
GVEPKTECERLAGTESPVREEPGEDFPAARRLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSK
VWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTKKDFEDLYTPVNGSIVIVRAGKITFAEKESL
IDASEDSQLEAAIRASLQETHFDSTQTKQDSRSDEESESELFSGSEEFISVCGSDEEEEVENLAKSRKSPHKDLGHRKEENRRPLTEPPV
RTDPGTATNHQGLPAVDSEILEMPPEKADGVVEGIDVNGPKAQLMLRYPDGKREQITLPEQAKLLALVKHVQSKGYPNERFELLTNFPRR

--------------------------------------------------------------
>In-frame_ENST00000360110_ENST00000535858_TCGA-13-1511-01A_TFRC_chr3_195796326_-_UBXN7_chr3_196089558_length(transcript)=1655nt_BP=971nt
CTCGCGAGCGTACGTGCCTCAGGAAGTGACGCACAGCCCCCCTGGGGGCCGGGGGCGGGGCCAGGCTATAAACCGCCGGTTAGGGGCCGC
CATCCCCTCAGAGCGTCGGGATATCGGGTGGCGGCTCGGGACGGAGGACGCGCTAGTGTTCTTCTGTGTGGCAGTTCAGAATGATGGATC
AAGCTAGATCAGCATTCTCTAACTTGTTTGGTGGAGAACCATTGTCATATACCCGGTTCAGCCTGGCTCGGCAAGTAGATGGCGATAACA
GTCATGTGGAGATGAAACTTGCTGTAGATGAAGAAGAAAATGCTGACAATAACACAAAGGCCAATGTCACAAAACCAAAAAGGTGTAGTG
GAAGTATCTGCTATGGGACTATTGCTGTGATCGTCTTTTTCTTGATTGGATTTATGATTGGCTACTTGGGCTATTGTAAAGGGGTAGAAC
CAAAAACTGAGTGTGAGAGACTGGCAGGAACCGAGTCTCCAGTGAGGGAGGAGCCAGGAGAGGACTTCCCTGCAGCACGTCGCTTATATT
GGGATGACCTGAAGAGAAAGTTGTCGGAGAAACTGGACAGCACAGACTTCACCGGCACCATCAAGCTGCTGAATGAAAATTCATATGTCC
CTCGTGAGGCTGGATCTCAAAAAGATGAAAATCTTGCGTTGTATGTTGAAAATCAATTTCGTGAATTTAAACTCAGCAAAGTCTGGCGTG
ATCAACATTTTGTTAAGATTCAGGTCAAAGACAGCGCTCAAAACTCGGTGATCATAGTTGATAAGAACGGTAGACTTGTTTACCTGGTGG
AGAATCCTGGGGGTTATGTGGCGTATAGTAAGGCTGCAACAGTTACTGGTAAACTGGTCCATGCTAATTTTGGTACTAAAAAAGATTTTG
AGGATTTATACACTCCTGTGAATGGATCTATAGTGATTGTCAGAGCAGGGAAAATCACCTTTGCAGAAAAGGAGAGCCTTATAGATGCAA
GTGAAGACAGCCAGCTAGAAGCTGCCATCAGAGCCTCCTTACAAGAAACACATTTTGATTCAACACAGACAAAACAGGATAGCCGCTCAG
ATGAAGAATCTGAATCTGAACTTTTTTCTGGCAGTGAGGAGTTCATATCCGTTTGTGGCTCTGATGAAGAAGAAGAGGTAGAGAATCTTG
CCAAGTCCAGAAAGTCTCCCCACAAAGATTTGGGGCATAGAAAAGAGGAGAATAGAAGGCCGCTGACTGAGCCACCAGTCAGAACTGATC
CTGGAACAGCCACAAACCACCAAGGATTGCCAGCTGTGGATTCAGAGATACTGGAGATGCCACCTGAAAAAGCAGATGGAGTAGTGGAGG
GGATAGATGTAAATGGACCAAAAGCACAGCTGATGTTGCGGTATCCAGATGGAAAAAGGGAACAGATCACTCTTCCAGAGCAAGCTAAAC
TGCTAGCTTTGGTGAAGCACGTGCAGTCTAAAGGATACCCAAATGAACGTTTTGAACTTCTCACCAACTTTCCTCGAAGGAAATTATCTC
ATCTGGACTATGATATTACATTGCAAGAGGCAGGCCTTTGTCCTCAAGAGACTGTCTTTGTACAGGAAAGAAATTAACACCATGGCTTGA

>In-frame_ENST00000360110_ENST00000535858_TCGA-13-1511-01A_TFRC_chr3_195796326_-_UBXN7_chr3_196089558_length(amino acids)=478AA_start in transcript=170_stop in transcript=1606
MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPKRCSGSICYGTIAVIVFFLIGFMIGYLGYCK
GVEPKTECERLAGTESPVREEPGEDFPAARRLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSK
VWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTKKDFEDLYTPVNGSIVIVRAGKITFAEKESL
IDASEDSQLEAAIRASLQETHFDSTQTKQDSRSDEESESELFSGSEEFISVCGSDEEEEVENLAKSRKSPHKDLGHRKEENRRPLTEPPV
RTDPGTATNHQGLPAVDSEILEMPPEKADGVVEGIDVNGPKAQLMLRYPDGKREQITLPEQAKLLALVKHVQSKGYPNERFELLTNFPRR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TFRC-UBXN7

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TFRC-UBXN7

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TFRC-UBXN7

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	TFRC	C0162316	Iron deficiency anemia	3	CTD_human
Hgene	TFRC	C0006142	Malignant neoplasm of breast	2	CTD_human
Hgene	TFRC	C0012715	Iron Metabolism Disorders	2	CTD_human
Hgene	TFRC	C0028754	Obesity	2	CTD_human
Hgene	TFRC	C0079487	Helicobacter Infections	2	CTD_human
Hgene	TFRC	C0678222	Breast Carcinoma	2	CTD_human
Hgene	TFRC	C1257931	Mammary Neoplasms, Human	2	CTD_human
Hgene	TFRC	C1458155	Mammary Neoplasms	2	CTD_human
Hgene	TFRC	C4704874	Mammary Carcinoma, Human	2	CTD_human
Hgene	TFRC	C0000786	Spontaneous abortion	1	CTD_human
Hgene	TFRC	C0000822	Abortion, Tubal	1	CTD_human
Hgene	TFRC	C0002875	Cooley's anemia	1	CTD_human
Hgene	TFRC	C0003756	Arenaviridae Infections	1	CTD_human
Hgene	TFRC	C0005283	beta Thalassemia	1	CTD_human
Hgene	TFRC	C0005684	Malignant neoplasm of urinary bladder	1	CTD_human
Hgene	TFRC	C0005695	Bladder Neoplasm	1	CTD_human
Hgene	TFRC	C0007621	Neoplastic Cell Transformation	1	CTD_human
Hgene	TFRC	C0009402	Colorectal Carcinoma	1	CTD_human
Hgene	TFRC	C0009404	Colorectal Neoplasms	1	CTD_human
Hgene	TFRC	C0017638	Glioma	1	CTD_human
Hgene	TFRC	C0019025	Hemoglobin F Disease	1	CTD_human
Hgene	TFRC	C0021368	Inflammation	1	CTD_human
Hgene	TFRC	C0023434	Chronic Lymphocytic Leukemia	1	CTD_human
Hgene	TFRC	C0024121	Lung Neoplasms	1	CTD_human
Hgene	TFRC	C0024302	Reticulosarcoma	1	CTD_human
Hgene	TFRC	C0024304	Lymphoma, Mixed-Cell	1	CTD_human
Hgene	TFRC	C0024305	Lymphoma, Non-Hodgkin	1	CTD_human
Hgene	TFRC	C0024306	Lymphoma, Undifferentiated	1	CTD_human
Hgene	TFRC	C0027055	Myocardial Reperfusion Injury	1	CTD_human
Hgene	TFRC	C0032460	Polycystic Ovary Syndrome	1	CTD_human
Hgene	TFRC	C0079740	High Grade Lymphoma (neoplasm)	1	CTD_human
Hgene	TFRC	C0079741	Lymphoma, Intermediate-Grade	1	CTD_human
Hgene	TFRC	C0079747	Low Grade Lymphoma (neoplasm)	1	CTD_human
Hgene	TFRC	C0079757	Diffuse Mixed-Cell Lymphoma	1	CTD_human
Hgene	TFRC	C0079770	Lymphoma, Small Noncleaved-Cell	1	CTD_human
Hgene	TFRC	C0085110	Severe Combined Immunodeficiency	1	CTD_human
Hgene	TFRC	C0085578	Thalassemia Minor	1	CTD_human
Hgene	TFRC	C0151744	Myocardial Ischemia	1	CTD_human
Hgene	TFRC	C0205671	Infections, Arenavirus	1	CTD_human
Hgene	TFRC	C0242379	Malignant neoplasm of lung	1	CTD_human
Hgene	TFRC	C0242583	Bare Lymphocyte Syndrome	1	CTD_human
Hgene	TFRC	C0259783	mixed gliomas	1	CTD_human
Hgene	TFRC	C0271979	Thalassemia Intermedia	1	CTD_human
Hgene	TFRC	C0494261	Combined immunodeficiency	1	GENOMICS_ENGLAND
Hgene	TFRC	C0555198	Malignant Glioma	1	CTD_human
Hgene	TFRC	C1136382	Sclerocystic Ovaries	1	CTD_human
Hgene	TFRC	C2700553	Omenn Syndrome	1	CTD_human
Hgene	TFRC	C3714542	Lymphoma, Diffuse	1	CTD_human
Hgene	TFRC	C3830362	Early Pregnancy Loss	1	CTD_human
Hgene	TFRC	C4225219	IMMUNODEFICIENCY 46	1	CTD_human;ORPHANET;UNIPROT
Hgene	TFRC	C4552766	Miscarriage	1	CTD_human
Hgene	TFRC	C4721532	Lymphoma, Non-Hodgkin, Familial	1	CTD_human