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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TGFB3-STIM2 (FusionGDB2 ID:89828)

Fusion Gene Summary for TGFB3-STIM2

check button Fusion gene summary
Fusion gene informationFusion gene name: TGFB3-STIM2
Fusion gene ID: 89828
HgeneTgene
Gene symbol

TGFB3

STIM2

Gene ID

7043

57620

Gene nametransforming growth factor beta 3stromal interaction molecule 2
SynonymsARVD|ARVD1|LDS5|RNHF|TGF-beta3-
Cytomap

14q24.3

4p15.2

Type of geneprotein-codingprotein-coding
Descriptiontransforming growth factor beta-3 proproteinprepro-transforming growth factor beta-3stromal interaction molecule 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000238682, ENST00000556285, 
ENST00000556674, 		ENST00000382009, 
ENST00000237364, ENST00000467087, 
ENST00000412829, ENST00000467011, 
ENST00000465503, ENST00000478425, 
Fusion gene scores* DoF score3 X 3 X 2=186 X 6 X 4=144
# samples 36
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TGFB3 [Title/Abstract] AND STIM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTGFB3(76446885)-STIM2(27024141), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTGFB3

GO:0001666

response to hypoxia

18156205

HgeneTGFB3

GO:0007179

transforming growth factor beta receptor signaling pathway

11157754|18718461

HgeneTGFB3

GO:0010718

positive regulation of epithelial to mesenchymal transition

18505915|18718461

HgeneTGFB3

GO:0010936

negative regulation of macrophage cytokine production

20875417

HgeneTGFB3

GO:0032570

response to progesterone

18039789

HgeneTGFB3

GO:0045216

cell-cell junction organization

18505915

HgeneTGFB3

GO:0045893

positive regulation of transcription, DNA-templated

18156205

HgeneTGFB3

GO:0050714

positive regulation of protein secretion

18505915

HgeneTGFB3

GO:0051496

positive regulation of stress fiber assembly

18718461

HgeneTGFB3

GO:0070483

detection of hypoxia

18156205

HgeneTGFB3

GO:1904706

negative regulation of vascular smooth muscle cell proliferation

26315405

HgeneTGFB3

GO:1905075

positive regulation of tight junction disassembly

18718461

TgeneSTIM2

GO:0032237

activation of store-operated calcium channel activity

17905723

TgeneSTIM2

GO:0051928

positive regulation of calcium ion transport

17905723


check buttonFusion gene breakpoints across TGFB3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across STIM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SD-01ATGFB3chr14

76446885

-STIM2chr4

27024141

+


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Fusion Gene ORF analysis for TGFB3-STIM2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000238682ENST00000382009TGFB3chr14

76446885

-STIM2chr4

27024141

+
In-frameENST00000238682ENST00000237364TGFB3chr14

76446885

-STIM2chr4

27024141

+
In-frameENST00000238682ENST00000467087TGFB3chr14

76446885

-STIM2chr4

27024141

+
5CDS-3UTRENST00000238682ENST00000412829TGFB3chr14

76446885

-STIM2chr4

27024141

+
5CDS-3UTRENST00000238682ENST00000467011TGFB3chr14

76446885

-STIM2chr4

27024141

+
5CDS-3UTRENST00000238682ENST00000465503TGFB3chr14

76446885

-STIM2chr4

27024141

+
5CDS-intronENST00000238682ENST00000478425TGFB3chr14

76446885

-STIM2chr4

27024141

+
In-frameENST00000556285ENST00000382009TGFB3chr14

76446885

-STIM2chr4

27024141

+
In-frameENST00000556285ENST00000237364TGFB3chr14

76446885

-STIM2chr4

27024141

+
In-frameENST00000556285ENST00000467087TGFB3chr14

76446885

-STIM2chr4

27024141

+
5CDS-3UTRENST00000556285ENST00000412829TGFB3chr14

76446885

-STIM2chr4

27024141

+
5CDS-3UTRENST00000556285ENST00000467011TGFB3chr14

76446885

-STIM2chr4

27024141

+
5CDS-3UTRENST00000556285ENST00000465503TGFB3chr14

76446885

-STIM2chr4

27024141

+
5CDS-intronENST00000556285ENST00000478425TGFB3chr14

76446885

-STIM2chr4

27024141

+
intron-3CDSENST00000556674ENST00000382009TGFB3chr14

76446885

-STIM2chr4

27024141

+
intron-3CDSENST00000556674ENST00000237364TGFB3chr14

76446885

-STIM2chr4

27024141

+
intron-3CDSENST00000556674ENST00000467087TGFB3chr14

76446885

-STIM2chr4

27024141

+
intron-3UTRENST00000556674ENST00000412829TGFB3chr14

76446885

-STIM2chr4

27024141

+
intron-3UTRENST00000556674ENST00000467011TGFB3chr14

76446885

-STIM2chr4

27024141

+
intron-3UTRENST00000556674ENST00000465503TGFB3chr14

76446885

-STIM2chr4

27024141

+
intron-intronENST00000556674ENST00000478425TGFB3chr14

76446885

-STIM2chr4

27024141

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000238682TGFB3chr1476446885-ENST00000382009STIM2chr427024141+35136501000455181
ENST00000238682TGFB3chr1476446885-ENST00000237364STIM2chr427024141+35136501000455181
ENST00000238682TGFB3chr1476446885-ENST00000467087STIM2chr427024141+35136501000455181
ENST00000556285TGFB3chr1476446885-ENST00000382009STIM2chr427024141+3315452802257181
ENST00000556285TGFB3chr1476446885-ENST00000237364STIM2chr427024141+3315452802257181
ENST00000556285TGFB3chr1476446885-ENST00000467087STIM2chr427024141+3315452802257181

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000238682ENST00000382009TGFB3chr1476446885-STIM2chr427024141+0.0133074320.9866926
ENST00000238682ENST00000237364TGFB3chr1476446885-STIM2chr427024141+0.0133074320.9866926
ENST00000238682ENST00000467087TGFB3chr1476446885-STIM2chr427024141+0.0133074320.9866926
ENST00000556285ENST00000382009TGFB3chr1476446885-STIM2chr427024141+0.0125132880.9874867
ENST00000556285ENST00000237364TGFB3chr1476446885-STIM2chr427024141+0.0125132880.9874867
ENST00000556285ENST00000467087TGFB3chr1476446885-STIM2chr427024141+0.0125132880.9874867

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Fusion Genomic Features for TGFB3-STIM2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TGFB3chr1476446884-STIM2chr427024140+0.283697780.7163022
TGFB3chr1476446884-STIM2chr427024140+0.283697780.7163022

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TGFB3-STIM2


check button Go to

FGviewer for the breakpoints of chr14:76446885-chr4:27024141

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTIM2chr14:76446885chr4:27024141ENST000004128291113730_746697.33333333333341050.3333333333333Compositional biasNote=Lys-rich
TgeneSTIM2chr14:76446885chr4:27024141ENST000004670871012730_746587.6666666666666747.0Compositional biasNote=Lys-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTGFB3chr14:76446885chr4:27024141ENST00000238682-17261_263117.33333333333333413.0MotifCell attachment site
TgeneSTIM2chr14:76446885chr4:27024141ENST00000412829111380_91697.33333333333341050.3333333333333Calcium binding.
TgeneSTIM2chr14:76446885chr4:27024141ENST00000467087101280_91587.6666666666666747.0Calcium binding.
TgeneSTIM2chr14:76446885chr4:27024141ENST000004128291113247_394697.33333333333341050.3333333333333Coiled coilOntology_term=ECO:0000255
TgeneSTIM2chr14:76446885chr4:27024141ENST000004670871012247_394587.6666666666666747.0Coiled coilOntology_term=ECO:0000255
TgeneSTIM2chr14:76446885chr4:27024141ENST000004128291113533_559697.33333333333341050.3333333333333Compositional biasNote=His/Pro-rich
TgeneSTIM2chr14:76446885chr4:27024141ENST000004670871012533_559587.6666666666666747.0Compositional biasNote=His/Pro-rich
TgeneSTIM2chr14:76446885chr4:27024141ENST000004128291113136_204697.33333333333341050.3333333333333DomainSAM
TgeneSTIM2chr14:76446885chr4:27024141ENST00000412829111367_102697.33333333333341050.3333333333333DomainNote=EF-hand
TgeneSTIM2chr14:76446885chr4:27024141ENST000004670871012136_204587.6666666666666747.0DomainSAM
TgeneSTIM2chr14:76446885chr4:27024141ENST00000467087101267_102587.6666666666666747.0DomainNote=EF-hand
TgeneSTIM2chr14:76446885chr4:27024141ENST00000412829111315_218697.33333333333341050.3333333333333Topological domainExtracellular
TgeneSTIM2chr14:76446885chr4:27024141ENST000004128291113236_746697.33333333333341050.3333333333333Topological domainCytoplasmic
TgeneSTIM2chr14:76446885chr4:27024141ENST00000467087101215_218587.6666666666666747.0Topological domainExtracellular
TgeneSTIM2chr14:76446885chr4:27024141ENST000004670871012236_746587.6666666666666747.0Topological domainCytoplasmic
TgeneSTIM2chr14:76446885chr4:27024141ENST000004128291113219_235697.33333333333341050.3333333333333TransmembraneHelical
TgeneSTIM2chr14:76446885chr4:27024141ENST000004670871012219_235587.6666666666666747.0TransmembraneHelical


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Fusion Gene Sequence for TGFB3-STIM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000238682_ENST00000382009_TCGA-A1-A0SD-01A_TGFB3_chr14_76446885_-_STIM2_chr4_27024141_length(transcript)=3513nt_BP=650nt
TGCTTGCCCTCCACCTGGCCTGCTGGGAGTCAGAGCCCAGCAAAACCTGTTTAGACACATGGACAAGAATCCCAGCGCTACAAGGCACAC
AGTCCGCTTCTTCGTCCTCAGGGTTGCCAGCGCTTCCTGGAAGTCCTGAAGCTCTCGCAGTGCAGTGAGTTCATGCACCTTCTTGCCAAG
CCTCAGTCTTTGGGATCTGGGGAGGCCGCCTGGTTTTCCTCCCTCCTTCTGCACGTCTGCTGGGGTCTCTTCCTCTCCAGGCCTTGCCGT
CCCCCTGGCCTCTCTTCCCAGCTCACACATGAAGATGCACTTGCAAAGGGCTCTGGTGGTCCTGGCCCTGCTGAACTTTGCCACGGTCAG
CCTCTCTCTGTCCACTTGCACCACCTTGGACTTCGGCCACATCAAGAAGAAGAGGGTGGAAGCCATTAGGGGACAGATCTTGAGCAAGCT
CAGGCTCACCAGCCCCCCTGAGCCAACGGTGATGACCCACGTCCCCTATCAGGTCCTGGCCCTTTACAACAGCACCCGGGAGCTGCTGGA
GGAGATGCATGGGGAGAGGGAGGAAGGCTGCACCCAGGAAAACACCGAGTCGGAATACTATGCCAAAGAAATCCATAAATTCGACATGAT
CCAGGGGCTGGCGGAGCACAGGAAGTGCCAGACACAGCTTCAGAATGTGACTCCTTAAATTCTTCCATTGGAAGGAAACAGTCTCCTCCT
TTAAGCCTCGAGATATACCAAACATTATCTCCGCGAAAGATATCAAGAGATGAGGTGTCCCTAGAGGATTCCTCCCGAGGGGATTCGCCT
GTAACTGTGGATGTGTCTTGGGGTTCTCCCGACTGTGTAGGTCTGACAGAAACTAAGAGTATGATCTTCAGTCCTGCAAGCAAAGTGTAC
AATGGCATTTTGGAGAAATCCTGTAGCATGAACCAGCTTTCCAGTGGCATCCCGGTGCCTAAACCTCGCCACACATCATGTTCCTCAGCT
GGCAACGACAGTAAACCAGTTCAGGAAGCCCCAAGTGTTGCCAGAATAAGCAGCATCCCACATGACCTTTGTCATAATGGAGAGAAAAGC
AAAAAGCCATCAAAAATCAAAAGCCTTTTTAAGAAGAAATCTAAGTGAACTGGCTGACTTGATGGAATCATGTTCAAGTGGCATCTGTAA
ACTATTATCCCCCACCCTCCACTCCCCACCTTTTTTTTGGTTTAATTTTAGGAATGTAACTCCATTGGGGCTTTCCAGGCCGGATGCCAT
AGTGGAACATCCAGAAGGGCAACTGTCTACTGTCTGCTTATTTAAGTGACTATATATAATCAATTCATCAAGCCAGTTATTACTGAAAAA
TCATTGAAATGAGACAGTTTACAGTCATTTCTGCCTATTTATTTCTGCTTTGTTCTCAGTGATGTATATGCAACATTTTGTTGAAAGCCA
CGATGGACTTACAAGCTTTAATGGACTCGTAAGCCAGCATGGGCTTGCAAAAATTTCTTGTTTACCAGAGCATCTTCTTATCTTTCCACA
GAGCTATTTACATCCTGGACTATATAACTTAAAAGAAGTAAAACGTAATTGCACTACTGTTTTCCAGACTGGAAAAAAAAAAAATCTCTG
CAAGTGAAACTGTATAGAGTTTATAAAATGACTATGGATAGGGGACTGTTTTCACTTTTAGATCAAAATGGGTTTTTAAGTAGAACCTAG
GGTTTCTAATTGACTTGATTTCTGGAAATGAAAACCCGCGCTTTTATTATGGGAAGCTTCTTGAACTGCATTTACTATTGTGAAGTTTCA
AGTCCCGCTGTAAAGATCATGTTGTTTTGTTTTCCCCAGGGCTTTCACTGTGATTTACTGCATTGCAGGCTGTATGATAAAACACACATA
ATTTAAAGAGAGAAGGCTCTTGATTCCTTATGCAAGTGGAAGAGTTGAAACTTGATTGAAGGACTTAAAACATTCACAACCTTAAGCCGA
GGTGGGGGGATATGGGGATTCAGGCAATTGTTTACACACTTTGAATAACTGCAAAGGATTTACGGTTTGTGAAAAATGTGTACTGTGGAA
AAGATAATAAATTGAAGACATTATTGTGTGGGATTGTGCTGATTTTTGTTGATAACACAAAAAACACTATGTTTTCTGGAGAGCTGTGTA
AGCTGTCTTGTTGCTTAGTTGCAATATAAGAAATAGTGATGTTTTGGACGTAAGTTGTCAACAAATTTCTATTTTATATTGTTATATTTT
TATGTAGTTTGAAATGTAAAAATGTTCTAATATCAAGATTAACAAATATAAATTTATGGTGCATTTAGATTGCGTTGTATTAATTTATAA
AGTATGGTGTTCATTAAATTGGTGGGTTGTATAAGGGTAGCTTTTGTTGTTAAAAAAACAGTAGAGAGTTAAGTTCCATATAGCAACAAA
GTATGTTAACATCTAGGGAGTTTCTGCTTATACCACTTTAAAAATATGCAATCATAAGTGATTTGGTTACTGCAATGCAGATGGATGTTT
GGATGAACAACTGATACATTTTAGTTAGAATGCTTTTTCAGCATTATGGCTAAAATATATGTCTAACCCAGTGCTATTTAGGTGAAAATG
CTAATTGATAAACCAGAAGTTTCTTTTGAGATTTGCTTTAAAGAAATGCTTTAGTAAGAATATGAACAATTTCCTGATGTCTCCTATAAA
TTGTGATTGTTTATTCTATTACTATTGTTAAAAACTTGAATGGTATTTATATTGGCTGATATTTATATACTTAATAGATTGAGTTCTGTA
AGGGCAAAAACGGATTGAAATGAACATAGCGTTTTGCACTAATGATAAGATAACCTGAGAGGTAGGGTTGAGGAACACAGGGTTGAAAGC
TGTTGGAGAGGGGAAAAGTTGTGCATAAAGAACTGAAAAGGGTTCTGGAGTGTTCATTCAGAGTGAAGGGAAAACTTTATCCTTCTATTT
CTTATAACCAGACAGGAGGAGTTCTTCCCTTTGAAAATTGCAAAAGGAATGAGAACTTTGCAGTTGGATGAATAGAGAAGGGAAAAGTTG
CTGGAGCACGGAGTGAAGATGGGAGGAGCTGTTAGCAAGGCCCACTGCTGCTCCTGGGTGAGAAGGGAGCTCTGGAGCAGGACCAGCTGG
GGGCCGGCACTGCTGCTTAGAGTGGAGGAGGCTGGCCAAAGAGACTGTGGGCTGTTTTCAGTCAGGGAGCATGTGCATTGTTTGTGCTCA
ATTTCAGACACTCATTTATAAACAAATTCAACCAAGGGATATTTACTGCTTTATGTTGCTTATGATAATTATTTTGCATTAATACAGTAT
ACACATTTGTAAATTCAACAGGAAATTATTGAGTTTTGGAAAGCTACAGTAATTTCTGTATTACATCATTTATATGTGAAAAGTTGGACA
TTTCTGTAAGTTTTTAAAATTATCCATTTGTTACTTTAACATTTTAAAATTATGGTGTTTTCCTGATTTTAAAAGCAATATTTTCCTTAC

>In-frame_ENST00000238682_ENST00000382009_TCGA-A1-A0SD-01A_TGFB3_chr14_76446885_-_STIM2_chr4_27024141_length(amino acids)=181AA_start in transcript=1000_stop in transcript=455
MSLPAEEHDVWRGLGTGMPLESWFMLQDFSKMPLYTLLAGLKIILLVSVRPTQSGEPQDTSTVTGESPREESSRDTSSLDIFRGDNVWYI
SRLKGGDCFLPMEEFKESHSEAVSGTSCAPPAPGSCRIYGFLWHSIPTRCFPGCSLPPSPHASPPAAPGCCCKGPGPDRGRGSSPLAQGG

--------------------------------------------------------------
>In-frame_ENST00000238682_ENST00000237364_TCGA-A1-A0SD-01A_TGFB3_chr14_76446885_-_STIM2_chr4_27024141_length(transcript)=3513nt_BP=650nt
TGCTTGCCCTCCACCTGGCCTGCTGGGAGTCAGAGCCCAGCAAAACCTGTTTAGACACATGGACAAGAATCCCAGCGCTACAAGGCACAC
AGTCCGCTTCTTCGTCCTCAGGGTTGCCAGCGCTTCCTGGAAGTCCTGAAGCTCTCGCAGTGCAGTGAGTTCATGCACCTTCTTGCCAAG
CCTCAGTCTTTGGGATCTGGGGAGGCCGCCTGGTTTTCCTCCCTCCTTCTGCACGTCTGCTGGGGTCTCTTCCTCTCCAGGCCTTGCCGT
CCCCCTGGCCTCTCTTCCCAGCTCACACATGAAGATGCACTTGCAAAGGGCTCTGGTGGTCCTGGCCCTGCTGAACTTTGCCACGGTCAG
CCTCTCTCTGTCCACTTGCACCACCTTGGACTTCGGCCACATCAAGAAGAAGAGGGTGGAAGCCATTAGGGGACAGATCTTGAGCAAGCT
CAGGCTCACCAGCCCCCCTGAGCCAACGGTGATGACCCACGTCCCCTATCAGGTCCTGGCCCTTTACAACAGCACCCGGGAGCTGCTGGA
GGAGATGCATGGGGAGAGGGAGGAAGGCTGCACCCAGGAAAACACCGAGTCGGAATACTATGCCAAAGAAATCCATAAATTCGACATGAT
CCAGGGGCTGGCGGAGCACAGGAAGTGCCAGACACAGCTTCAGAATGTGACTCCTTAAATTCTTCCATTGGAAGGAAACAGTCTCCTCCT
TTAAGCCTCGAGATATACCAAACATTATCTCCGCGAAAGATATCAAGAGATGAGGTGTCCCTAGAGGATTCCTCCCGAGGGGATTCGCCT
GTAACTGTGGATGTGTCTTGGGGTTCTCCCGACTGTGTAGGTCTGACAGAAACTAAGAGTATGATCTTCAGTCCTGCAAGCAAAGTGTAC
AATGGCATTTTGGAGAAATCCTGTAGCATGAACCAGCTTTCCAGTGGCATCCCGGTGCCTAAACCTCGCCACACATCATGTTCCTCAGCT
GGCAACGACAGTAAACCAGTTCAGGAAGCCCCAAGTGTTGCCAGAATAAGCAGCATCCCACATGACCTTTGTCATAATGGAGAGAAAAGC
AAAAAGCCATCAAAAATCAAAAGCCTTTTTAAGAAGAAATCTAAGTGAACTGGCTGACTTGATGGAATCATGTTCAAGTGGCATCTGTAA
ACTATTATCCCCCACCCTCCACTCCCCACCTTTTTTTTGGTTTAATTTTAGGAATGTAACTCCATTGGGGCTTTCCAGGCCGGATGCCAT
AGTGGAACATCCAGAAGGGCAACTGTCTACTGTCTGCTTATTTAAGTGACTATATATAATCAATTCATCAAGCCAGTTATTACTGAAAAA
TCATTGAAATGAGACAGTTTACAGTCATTTCTGCCTATTTATTTCTGCTTTGTTCTCAGTGATGTATATGCAACATTTTGTTGAAAGCCA
CGATGGACTTACAAGCTTTAATGGACTCGTAAGCCAGCATGGGCTTGCAAAAATTTCTTGTTTACCAGAGCATCTTCTTATCTTTCCACA
GAGCTATTTACATCCTGGACTATATAACTTAAAAGAAGTAAAACGTAATTGCACTACTGTTTTCCAGACTGGAAAAAAAAAAAATCTCTG
CAAGTGAAACTGTATAGAGTTTATAAAATGACTATGGATAGGGGACTGTTTTCACTTTTAGATCAAAATGGGTTTTTAAGTAGAACCTAG
GGTTTCTAATTGACTTGATTTCTGGAAATGAAAACCCGCGCTTTTATTATGGGAAGCTTCTTGAACTGCATTTACTATTGTGAAGTTTCA
AGTCCCGCTGTAAAGATCATGTTGTTTTGTTTTCCCCAGGGCTTTCACTGTGATTTACTGCATTGCAGGCTGTATGATAAAACACACATA
ATTTAAAGAGAGAAGGCTCTTGATTCCTTATGCAAGTGGAAGAGTTGAAACTTGATTGAAGGACTTAAAACATTCACAACCTTAAGCCGA
GGTGGGGGGATATGGGGATTCAGGCAATTGTTTACACACTTTGAATAACTGCAAAGGATTTACGGTTTGTGAAAAATGTGTACTGTGGAA
AAGATAATAAATTGAAGACATTATTGTGTGGGATTGTGCTGATTTTTGTTGATAACACAAAAAACACTATGTTTTCTGGAGAGCTGTGTA
AGCTGTCTTGTTGCTTAGTTGCAATATAAGAAATAGTGATGTTTTGGACGTAAGTTGTCAACAAATTTCTATTTTATATTGTTATATTTT
TATGTAGTTTGAAATGTAAAAATGTTCTAATATCAAGATTAACAAATATAAATTTATGGTGCATTTAGATTGCGTTGTATTAATTTATAA
AGTATGGTGTTCATTAAATTGGTGGGTTGTATAAGGGTAGCTTTTGTTGTTAAAAAAACAGTAGAGAGTTAAGTTCCATATAGCAACAAA
GTATGTTAACATCTAGGGAGTTTCTGCTTATACCACTTTAAAAATATGCAATCATAAGTGATTTGGTTACTGCAATGCAGATGGATGTTT
GGATGAACAACTGATACATTTTAGTTAGAATGCTTTTTCAGCATTATGGCTAAAATATATGTCTAACCCAGTGCTATTTAGGTGAAAATG
CTAATTGATAAACCAGAAGTTTCTTTTGAGATTTGCTTTAAAGAAATGCTTTAGTAAGAATATGAACAATTTCCTGATGTCTCCTATAAA
TTGTGATTGTTTATTCTATTACTATTGTTAAAAACTTGAATGGTATTTATATTGGCTGATATTTATATACTTAATAGATTGAGTTCTGTA
AGGGCAAAAACGGATTGAAATGAACATAGCGTTTTGCACTAATGATAAGATAACCTGAGAGGTAGGGTTGAGGAACACAGGGTTGAAAGC
TGTTGGAGAGGGGAAAAGTTGTGCATAAAGAACTGAAAAGGGTTCTGGAGTGTTCATTCAGAGTGAAGGGAAAACTTTATCCTTCTATTT
CTTATAACCAGACAGGAGGAGTTCTTCCCTTTGAAAATTGCAAAAGGAATGAGAACTTTGCAGTTGGATGAATAGAGAAGGGAAAAGTTG
CTGGAGCACGGAGTGAAGATGGGAGGAGCTGTTAGCAAGGCCCACTGCTGCTCCTGGGTGAGAAGGGAGCTCTGGAGCAGGACCAGCTGG
GGGCCGGCACTGCTGCTTAGAGTGGAGGAGGCTGGCCAAAGAGACTGTGGGCTGTTTTCAGTCAGGGAGCATGTGCATTGTTTGTGCTCA
ATTTCAGACACTCATTTATAAACAAATTCAACCAAGGGATATTTACTGCTTTATGTTGCTTATGATAATTATTTTGCATTAATACAGTAT
ACACATTTGTAAATTCAACAGGAAATTATTGAGTTTTGGAAAGCTACAGTAATTTCTGTATTACATCATTTATATGTGAAAAGTTGGACA
TTTCTGTAAGTTTTTAAAATTATCCATTTGTTACTTTAACATTTTAAAATTATGGTGTTTTCCTGATTTTAAAAGCAATATTTTCCTTAC

>In-frame_ENST00000238682_ENST00000237364_TCGA-A1-A0SD-01A_TGFB3_chr14_76446885_-_STIM2_chr4_27024141_length(amino acids)=181AA_start in transcript=1000_stop in transcript=455
MSLPAEEHDVWRGLGTGMPLESWFMLQDFSKMPLYTLLAGLKIILLVSVRPTQSGEPQDTSTVTGESPREESSRDTSSLDIFRGDNVWYI
SRLKGGDCFLPMEEFKESHSEAVSGTSCAPPAPGSCRIYGFLWHSIPTRCFPGCSLPPSPHASPPAAPGCCCKGPGPDRGRGSSPLAQGG

--------------------------------------------------------------
>In-frame_ENST00000238682_ENST00000467087_TCGA-A1-A0SD-01A_TGFB3_chr14_76446885_-_STIM2_chr4_27024141_length(transcript)=3513nt_BP=650nt
TGCTTGCCCTCCACCTGGCCTGCTGGGAGTCAGAGCCCAGCAAAACCTGTTTAGACACATGGACAAGAATCCCAGCGCTACAAGGCACAC
AGTCCGCTTCTTCGTCCTCAGGGTTGCCAGCGCTTCCTGGAAGTCCTGAAGCTCTCGCAGTGCAGTGAGTTCATGCACCTTCTTGCCAAG
CCTCAGTCTTTGGGATCTGGGGAGGCCGCCTGGTTTTCCTCCCTCCTTCTGCACGTCTGCTGGGGTCTCTTCCTCTCCAGGCCTTGCCGT
CCCCCTGGCCTCTCTTCCCAGCTCACACATGAAGATGCACTTGCAAAGGGCTCTGGTGGTCCTGGCCCTGCTGAACTTTGCCACGGTCAG
CCTCTCTCTGTCCACTTGCACCACCTTGGACTTCGGCCACATCAAGAAGAAGAGGGTGGAAGCCATTAGGGGACAGATCTTGAGCAAGCT
CAGGCTCACCAGCCCCCCTGAGCCAACGGTGATGACCCACGTCCCCTATCAGGTCCTGGCCCTTTACAACAGCACCCGGGAGCTGCTGGA
GGAGATGCATGGGGAGAGGGAGGAAGGCTGCACCCAGGAAAACACCGAGTCGGAATACTATGCCAAAGAAATCCATAAATTCGACATGAT
CCAGGGGCTGGCGGAGCACAGGAAGTGCCAGACACAGCTTCAGAATGTGACTCCTTAAATTCTTCCATTGGAAGGAAACAGTCTCCTCCT
TTAAGCCTCGAGATATACCAAACATTATCTCCGCGAAAGATATCAAGAGATGAGGTGTCCCTAGAGGATTCCTCCCGAGGGGATTCGCCT
GTAACTGTGGATGTGTCTTGGGGTTCTCCCGACTGTGTAGGTCTGACAGAAACTAAGAGTATGATCTTCAGTCCTGCAAGCAAAGTGTAC
AATGGCATTTTGGAGAAATCCTGTAGCATGAACCAGCTTTCCAGTGGCATCCCGGTGCCTAAACCTCGCCACACATCATGTTCCTCAGCT
GGCAACGACAGTAAACCAGTTCAGGAAGCCCCAAGTGTTGCCAGAATAAGCAGCATCCCACATGACCTTTGTCATAATGGAGAGAAAAGC
AAAAAGCCATCAAAAATCAAAAGCCTTTTTAAGAAGAAATCTAAGTGAACTGGCTGACTTGATGGAATCATGTTCAAGTGGCATCTGTAA
ACTATTATCCCCCACCCTCCACTCCCCACCTTTTTTTTGGTTTAATTTTAGGAATGTAACTCCATTGGGGCTTTCCAGGCCGGATGCCAT
AGTGGAACATCCAGAAGGGCAACTGTCTACTGTCTGCTTATTTAAGTGACTATATATAATCAATTCATCAAGCCAGTTATTACTGAAAAA
TCATTGAAATGAGACAGTTTACAGTCATTTCTGCCTATTTATTTCTGCTTTGTTCTCAGTGATGTATATGCAACATTTTGTTGAAAGCCA
CGATGGACTTACAAGCTTTAATGGACTCGTAAGCCAGCATGGGCTTGCAAAAATTTCTTGTTTACCAGAGCATCTTCTTATCTTTCCACA
GAGCTATTTACATCCTGGACTATATAACTTAAAAGAAGTAAAACGTAATTGCACTACTGTTTTCCAGACTGGAAAAAAAAAAAATCTCTG
CAAGTGAAACTGTATAGAGTTTATAAAATGACTATGGATAGGGGACTGTTTTCACTTTTAGATCAAAATGGGTTTTTAAGTAGAACCTAG
GGTTTCTAATTGACTTGATTTCTGGAAATGAAAACCCGCGCTTTTATTATGGGAAGCTTCTTGAACTGCATTTACTATTGTGAAGTTTCA
AGTCCCGCTGTAAAGATCATGTTGTTTTGTTTTCCCCAGGGCTTTCACTGTGATTTACTGCATTGCAGGCTGTATGATAAAACACACATA
ATTTAAAGAGAGAAGGCTCTTGATTCCTTATGCAAGTGGAAGAGTTGAAACTTGATTGAAGGACTTAAAACATTCACAACCTTAAGCCGA
GGTGGGGGGATATGGGGATTCAGGCAATTGTTTACACACTTTGAATAACTGCAAAGGATTTACGGTTTGTGAAAAATGTGTACTGTGGAA
AAGATAATAAATTGAAGACATTATTGTGTGGGATTGTGCTGATTTTTGTTGATAACACAAAAAACACTATGTTTTCTGGAGAGCTGTGTA
AGCTGTCTTGTTGCTTAGTTGCAATATAAGAAATAGTGATGTTTTGGACGTAAGTTGTCAACAAATTTCTATTTTATATTGTTATATTTT
TATGTAGTTTGAAATGTAAAAATGTTCTAATATCAAGATTAACAAATATAAATTTATGGTGCATTTAGATTGCGTTGTATTAATTTATAA
AGTATGGTGTTCATTAAATTGGTGGGTTGTATAAGGGTAGCTTTTGTTGTTAAAAAAACAGTAGAGAGTTAAGTTCCATATAGCAACAAA
GTATGTTAACATCTAGGGAGTTTCTGCTTATACCACTTTAAAAATATGCAATCATAAGTGATTTGGTTACTGCAATGCAGATGGATGTTT
GGATGAACAACTGATACATTTTAGTTAGAATGCTTTTTCAGCATTATGGCTAAAATATATGTCTAACCCAGTGCTATTTAGGTGAAAATG
CTAATTGATAAACCAGAAGTTTCTTTTGAGATTTGCTTTAAAGAAATGCTTTAGTAAGAATATGAACAATTTCCTGATGTCTCCTATAAA
TTGTGATTGTTTATTCTATTACTATTGTTAAAAACTTGAATGGTATTTATATTGGCTGATATTTATATACTTAATAGATTGAGTTCTGTA
AGGGCAAAAACGGATTGAAATGAACATAGCGTTTTGCACTAATGATAAGATAACCTGAGAGGTAGGGTTGAGGAACACAGGGTTGAAAGC
TGTTGGAGAGGGGAAAAGTTGTGCATAAAGAACTGAAAAGGGTTCTGGAGTGTTCATTCAGAGTGAAGGGAAAACTTTATCCTTCTATTT
CTTATAACCAGACAGGAGGAGTTCTTCCCTTTGAAAATTGCAAAAGGAATGAGAACTTTGCAGTTGGATGAATAGAGAAGGGAAAAGTTG
CTGGAGCACGGAGTGAAGATGGGAGGAGCTGTTAGCAAGGCCCACTGCTGCTCCTGGGTGAGAAGGGAGCTCTGGAGCAGGACCAGCTGG
GGGCCGGCACTGCTGCTTAGAGTGGAGGAGGCTGGCCAAAGAGACTGTGGGCTGTTTTCAGTCAGGGAGCATGTGCATTGTTTGTGCTCA
ATTTCAGACACTCATTTATAAACAAATTCAACCAAGGGATATTTACTGCTTTATGTTGCTTATGATAATTATTTTGCATTAATACAGTAT
ACACATTTGTAAATTCAACAGGAAATTATTGAGTTTTGGAAAGCTACAGTAATTTCTGTATTACATCATTTATATGTGAAAAGTTGGACA
TTTCTGTAAGTTTTTAAAATTATCCATTTGTTACTTTAACATTTTAAAATTATGGTGTTTTCCTGATTTTAAAAGCAATATTTTCCTTAC

>In-frame_ENST00000238682_ENST00000467087_TCGA-A1-A0SD-01A_TGFB3_chr14_76446885_-_STIM2_chr4_27024141_length(amino acids)=181AA_start in transcript=1000_stop in transcript=455
MSLPAEEHDVWRGLGTGMPLESWFMLQDFSKMPLYTLLAGLKIILLVSVRPTQSGEPQDTSTVTGESPREESSRDTSSLDIFRGDNVWYI
SRLKGGDCFLPMEEFKESHSEAVSGTSCAPPAPGSCRIYGFLWHSIPTRCFPGCSLPPSPHASPPAAPGCCCKGPGPDRGRGSSPLAQGG

--------------------------------------------------------------
>In-frame_ENST00000556285_ENST00000382009_TCGA-A1-A0SD-01A_TGFB3_chr14_76446885_-_STIM2_chr4_27024141_length(transcript)=3315nt_BP=452nt
GGGGAGGCCGCCTGGTTTTCCTCCCTCCTTCTGCACGTCTGCTGGGGTCTCTTCCTCTCCAGGCCTTGCCGTCCCCCTGGCCTCTCTTCC
CAGCTCACACATGAAGATGCACTTGCAAAGGGCTCTGGTGGTCCTGGCCCTGCTGAACTTTGCCACGGTCAGCCTCTCTCTGTCCACTTG
CACCACCTTGGACTTCGGCCACATCAAGAAGAAGAGGGTGGAAGCCATTAGGGGACAGATCTTGAGCAAGCTCAGGCTCACCAGCCCCCC
TGAGCCAACGGTGATGACCCACGTCCCCTATCAGGTCCTGGCCCTTTACAACAGCACCCGGGAGCTGCTGGAGGAGATGCATGGGGAGAG
GGAGGAAGGCTGCACCCAGGAAAACACCGAGTCGGAATACTATGCCAAAGAAATCCATAAATTCGACATGATCCAGGGGCTGGCGGAGCA
CAGGAAGTGCCAGACACAGCTTCAGAATGTGACTCCTTAAATTCTTCCATTGGAAGGAAACAGTCTCCTCCTTTAAGCCTCGAGATATAC
CAAACATTATCTCCGCGAAAGATATCAAGAGATGAGGTGTCCCTAGAGGATTCCTCCCGAGGGGATTCGCCTGTAACTGTGGATGTGTCT
TGGGGTTCTCCCGACTGTGTAGGTCTGACAGAAACTAAGAGTATGATCTTCAGTCCTGCAAGCAAAGTGTACAATGGCATTTTGGAGAAA
TCCTGTAGCATGAACCAGCTTTCCAGTGGCATCCCGGTGCCTAAACCTCGCCACACATCATGTTCCTCAGCTGGCAACGACAGTAAACCA
GTTCAGGAAGCCCCAAGTGTTGCCAGAATAAGCAGCATCCCACATGACCTTTGTCATAATGGAGAGAAAAGCAAAAAGCCATCAAAAATC
AAAAGCCTTTTTAAGAAGAAATCTAAGTGAACTGGCTGACTTGATGGAATCATGTTCAAGTGGCATCTGTAAACTATTATCCCCCACCCT
CCACTCCCCACCTTTTTTTTGGTTTAATTTTAGGAATGTAACTCCATTGGGGCTTTCCAGGCCGGATGCCATAGTGGAACATCCAGAAGG
GCAACTGTCTACTGTCTGCTTATTTAAGTGACTATATATAATCAATTCATCAAGCCAGTTATTACTGAAAAATCATTGAAATGAGACAGT
TTACAGTCATTTCTGCCTATTTATTTCTGCTTTGTTCTCAGTGATGTATATGCAACATTTTGTTGAAAGCCACGATGGACTTACAAGCTT
TAATGGACTCGTAAGCCAGCATGGGCTTGCAAAAATTTCTTGTTTACCAGAGCATCTTCTTATCTTTCCACAGAGCTATTTACATCCTGG
ACTATATAACTTAAAAGAAGTAAAACGTAATTGCACTACTGTTTTCCAGACTGGAAAAAAAAAAAATCTCTGCAAGTGAAACTGTATAGA
GTTTATAAAATGACTATGGATAGGGGACTGTTTTCACTTTTAGATCAAAATGGGTTTTTAAGTAGAACCTAGGGTTTCTAATTGACTTGA
TTTCTGGAAATGAAAACCCGCGCTTTTATTATGGGAAGCTTCTTGAACTGCATTTACTATTGTGAAGTTTCAAGTCCCGCTGTAAAGATC
ATGTTGTTTTGTTTTCCCCAGGGCTTTCACTGTGATTTACTGCATTGCAGGCTGTATGATAAAACACACATAATTTAAAGAGAGAAGGCT
CTTGATTCCTTATGCAAGTGGAAGAGTTGAAACTTGATTGAAGGACTTAAAACATTCACAACCTTAAGCCGAGGTGGGGGGATATGGGGA
TTCAGGCAATTGTTTACACACTTTGAATAACTGCAAAGGATTTACGGTTTGTGAAAAATGTGTACTGTGGAAAAGATAATAAATTGAAGA
CATTATTGTGTGGGATTGTGCTGATTTTTGTTGATAACACAAAAAACACTATGTTTTCTGGAGAGCTGTGTAAGCTGTCTTGTTGCTTAG
TTGCAATATAAGAAATAGTGATGTTTTGGACGTAAGTTGTCAACAAATTTCTATTTTATATTGTTATATTTTTATGTAGTTTGAAATGTA
AAAATGTTCTAATATCAAGATTAACAAATATAAATTTATGGTGCATTTAGATTGCGTTGTATTAATTTATAAAGTATGGTGTTCATTAAA
TTGGTGGGTTGTATAAGGGTAGCTTTTGTTGTTAAAAAAACAGTAGAGAGTTAAGTTCCATATAGCAACAAAGTATGTTAACATCTAGGG
AGTTTCTGCTTATACCACTTTAAAAATATGCAATCATAAGTGATTTGGTTACTGCAATGCAGATGGATGTTTGGATGAACAACTGATACA
TTTTAGTTAGAATGCTTTTTCAGCATTATGGCTAAAATATATGTCTAACCCAGTGCTATTTAGGTGAAAATGCTAATTGATAAACCAGAA
GTTTCTTTTGAGATTTGCTTTAAAGAAATGCTTTAGTAAGAATATGAACAATTTCCTGATGTCTCCTATAAATTGTGATTGTTTATTCTA
TTACTATTGTTAAAAACTTGAATGGTATTTATATTGGCTGATATTTATATACTTAATAGATTGAGTTCTGTAAGGGCAAAAACGGATTGA
AATGAACATAGCGTTTTGCACTAATGATAAGATAACCTGAGAGGTAGGGTTGAGGAACACAGGGTTGAAAGCTGTTGGAGAGGGGAAAAG
TTGTGCATAAAGAACTGAAAAGGGTTCTGGAGTGTTCATTCAGAGTGAAGGGAAAACTTTATCCTTCTATTTCTTATAACCAGACAGGAG
GAGTTCTTCCCTTTGAAAATTGCAAAAGGAATGAGAACTTTGCAGTTGGATGAATAGAGAAGGGAAAAGTTGCTGGAGCACGGAGTGAAG
ATGGGAGGAGCTGTTAGCAAGGCCCACTGCTGCTCCTGGGTGAGAAGGGAGCTCTGGAGCAGGACCAGCTGGGGGCCGGCACTGCTGCTT
AGAGTGGAGGAGGCTGGCCAAAGAGACTGTGGGCTGTTTTCAGTCAGGGAGCATGTGCATTGTTTGTGCTCAATTTCAGACACTCATTTA
TAAACAAATTCAACCAAGGGATATTTACTGCTTTATGTTGCTTATGATAATTATTTTGCATTAATACAGTATACACATTTGTAAATTCAA
CAGGAAATTATTGAGTTTTGGAAAGCTACAGTAATTTCTGTATTACATCATTTATATGTGAAAAGTTGGACATTTCTGTAAGTTTTTAAA

>In-frame_ENST00000556285_ENST00000382009_TCGA-A1-A0SD-01A_TGFB3_chr14_76446885_-_STIM2_chr4_27024141_length(amino acids)=181AA_start in transcript=802_stop in transcript=257
MSLPAEEHDVWRGLGTGMPLESWFMLQDFSKMPLYTLLAGLKIILLVSVRPTQSGEPQDTSTVTGESPREESSRDTSSLDIFRGDNVWYI
SRLKGGDCFLPMEEFKESHSEAVSGTSCAPPAPGSCRIYGFLWHSIPTRCFPGCSLPPSPHASPPAAPGCCCKGPGPDRGRGSSPLAQGG

--------------------------------------------------------------
>In-frame_ENST00000556285_ENST00000237364_TCGA-A1-A0SD-01A_TGFB3_chr14_76446885_-_STIM2_chr4_27024141_length(transcript)=3315nt_BP=452nt
GGGGAGGCCGCCTGGTTTTCCTCCCTCCTTCTGCACGTCTGCTGGGGTCTCTTCCTCTCCAGGCCTTGCCGTCCCCCTGGCCTCTCTTCC
CAGCTCACACATGAAGATGCACTTGCAAAGGGCTCTGGTGGTCCTGGCCCTGCTGAACTTTGCCACGGTCAGCCTCTCTCTGTCCACTTG
CACCACCTTGGACTTCGGCCACATCAAGAAGAAGAGGGTGGAAGCCATTAGGGGACAGATCTTGAGCAAGCTCAGGCTCACCAGCCCCCC
TGAGCCAACGGTGATGACCCACGTCCCCTATCAGGTCCTGGCCCTTTACAACAGCACCCGGGAGCTGCTGGAGGAGATGCATGGGGAGAG
GGAGGAAGGCTGCACCCAGGAAAACACCGAGTCGGAATACTATGCCAAAGAAATCCATAAATTCGACATGATCCAGGGGCTGGCGGAGCA
CAGGAAGTGCCAGACACAGCTTCAGAATGTGACTCCTTAAATTCTTCCATTGGAAGGAAACAGTCTCCTCCTTTAAGCCTCGAGATATAC
CAAACATTATCTCCGCGAAAGATATCAAGAGATGAGGTGTCCCTAGAGGATTCCTCCCGAGGGGATTCGCCTGTAACTGTGGATGTGTCT
TGGGGTTCTCCCGACTGTGTAGGTCTGACAGAAACTAAGAGTATGATCTTCAGTCCTGCAAGCAAAGTGTACAATGGCATTTTGGAGAAA
TCCTGTAGCATGAACCAGCTTTCCAGTGGCATCCCGGTGCCTAAACCTCGCCACACATCATGTTCCTCAGCTGGCAACGACAGTAAACCA
GTTCAGGAAGCCCCAAGTGTTGCCAGAATAAGCAGCATCCCACATGACCTTTGTCATAATGGAGAGAAAAGCAAAAAGCCATCAAAAATC
AAAAGCCTTTTTAAGAAGAAATCTAAGTGAACTGGCTGACTTGATGGAATCATGTTCAAGTGGCATCTGTAAACTATTATCCCCCACCCT
CCACTCCCCACCTTTTTTTTGGTTTAATTTTAGGAATGTAACTCCATTGGGGCTTTCCAGGCCGGATGCCATAGTGGAACATCCAGAAGG
GCAACTGTCTACTGTCTGCTTATTTAAGTGACTATATATAATCAATTCATCAAGCCAGTTATTACTGAAAAATCATTGAAATGAGACAGT
TTACAGTCATTTCTGCCTATTTATTTCTGCTTTGTTCTCAGTGATGTATATGCAACATTTTGTTGAAAGCCACGATGGACTTACAAGCTT
TAATGGACTCGTAAGCCAGCATGGGCTTGCAAAAATTTCTTGTTTACCAGAGCATCTTCTTATCTTTCCACAGAGCTATTTACATCCTGG
ACTATATAACTTAAAAGAAGTAAAACGTAATTGCACTACTGTTTTCCAGACTGGAAAAAAAAAAAATCTCTGCAAGTGAAACTGTATAGA
GTTTATAAAATGACTATGGATAGGGGACTGTTTTCACTTTTAGATCAAAATGGGTTTTTAAGTAGAACCTAGGGTTTCTAATTGACTTGA
TTTCTGGAAATGAAAACCCGCGCTTTTATTATGGGAAGCTTCTTGAACTGCATTTACTATTGTGAAGTTTCAAGTCCCGCTGTAAAGATC
ATGTTGTTTTGTTTTCCCCAGGGCTTTCACTGTGATTTACTGCATTGCAGGCTGTATGATAAAACACACATAATTTAAAGAGAGAAGGCT
CTTGATTCCTTATGCAAGTGGAAGAGTTGAAACTTGATTGAAGGACTTAAAACATTCACAACCTTAAGCCGAGGTGGGGGGATATGGGGA
TTCAGGCAATTGTTTACACACTTTGAATAACTGCAAAGGATTTACGGTTTGTGAAAAATGTGTACTGTGGAAAAGATAATAAATTGAAGA
CATTATTGTGTGGGATTGTGCTGATTTTTGTTGATAACACAAAAAACACTATGTTTTCTGGAGAGCTGTGTAAGCTGTCTTGTTGCTTAG
TTGCAATATAAGAAATAGTGATGTTTTGGACGTAAGTTGTCAACAAATTTCTATTTTATATTGTTATATTTTTATGTAGTTTGAAATGTA
AAAATGTTCTAATATCAAGATTAACAAATATAAATTTATGGTGCATTTAGATTGCGTTGTATTAATTTATAAAGTATGGTGTTCATTAAA
TTGGTGGGTTGTATAAGGGTAGCTTTTGTTGTTAAAAAAACAGTAGAGAGTTAAGTTCCATATAGCAACAAAGTATGTTAACATCTAGGG
AGTTTCTGCTTATACCACTTTAAAAATATGCAATCATAAGTGATTTGGTTACTGCAATGCAGATGGATGTTTGGATGAACAACTGATACA
TTTTAGTTAGAATGCTTTTTCAGCATTATGGCTAAAATATATGTCTAACCCAGTGCTATTTAGGTGAAAATGCTAATTGATAAACCAGAA
GTTTCTTTTGAGATTTGCTTTAAAGAAATGCTTTAGTAAGAATATGAACAATTTCCTGATGTCTCCTATAAATTGTGATTGTTTATTCTA
TTACTATTGTTAAAAACTTGAATGGTATTTATATTGGCTGATATTTATATACTTAATAGATTGAGTTCTGTAAGGGCAAAAACGGATTGA
AATGAACATAGCGTTTTGCACTAATGATAAGATAACCTGAGAGGTAGGGTTGAGGAACACAGGGTTGAAAGCTGTTGGAGAGGGGAAAAG
TTGTGCATAAAGAACTGAAAAGGGTTCTGGAGTGTTCATTCAGAGTGAAGGGAAAACTTTATCCTTCTATTTCTTATAACCAGACAGGAG
GAGTTCTTCCCTTTGAAAATTGCAAAAGGAATGAGAACTTTGCAGTTGGATGAATAGAGAAGGGAAAAGTTGCTGGAGCACGGAGTGAAG
ATGGGAGGAGCTGTTAGCAAGGCCCACTGCTGCTCCTGGGTGAGAAGGGAGCTCTGGAGCAGGACCAGCTGGGGGCCGGCACTGCTGCTT
AGAGTGGAGGAGGCTGGCCAAAGAGACTGTGGGCTGTTTTCAGTCAGGGAGCATGTGCATTGTTTGTGCTCAATTTCAGACACTCATTTA
TAAACAAATTCAACCAAGGGATATTTACTGCTTTATGTTGCTTATGATAATTATTTTGCATTAATACAGTATACACATTTGTAAATTCAA
CAGGAAATTATTGAGTTTTGGAAAGCTACAGTAATTTCTGTATTACATCATTTATATGTGAAAAGTTGGACATTTCTGTAAGTTTTTAAA

>In-frame_ENST00000556285_ENST00000237364_TCGA-A1-A0SD-01A_TGFB3_chr14_76446885_-_STIM2_chr4_27024141_length(amino acids)=181AA_start in transcript=802_stop in transcript=257
MSLPAEEHDVWRGLGTGMPLESWFMLQDFSKMPLYTLLAGLKIILLVSVRPTQSGEPQDTSTVTGESPREESSRDTSSLDIFRGDNVWYI
SRLKGGDCFLPMEEFKESHSEAVSGTSCAPPAPGSCRIYGFLWHSIPTRCFPGCSLPPSPHASPPAAPGCCCKGPGPDRGRGSSPLAQGG

--------------------------------------------------------------
>In-frame_ENST00000556285_ENST00000467087_TCGA-A1-A0SD-01A_TGFB3_chr14_76446885_-_STIM2_chr4_27024141_length(transcript)=3315nt_BP=452nt
GGGGAGGCCGCCTGGTTTTCCTCCCTCCTTCTGCACGTCTGCTGGGGTCTCTTCCTCTCCAGGCCTTGCCGTCCCCCTGGCCTCTCTTCC
CAGCTCACACATGAAGATGCACTTGCAAAGGGCTCTGGTGGTCCTGGCCCTGCTGAACTTTGCCACGGTCAGCCTCTCTCTGTCCACTTG
CACCACCTTGGACTTCGGCCACATCAAGAAGAAGAGGGTGGAAGCCATTAGGGGACAGATCTTGAGCAAGCTCAGGCTCACCAGCCCCCC
TGAGCCAACGGTGATGACCCACGTCCCCTATCAGGTCCTGGCCCTTTACAACAGCACCCGGGAGCTGCTGGAGGAGATGCATGGGGAGAG
GGAGGAAGGCTGCACCCAGGAAAACACCGAGTCGGAATACTATGCCAAAGAAATCCATAAATTCGACATGATCCAGGGGCTGGCGGAGCA
CAGGAAGTGCCAGACACAGCTTCAGAATGTGACTCCTTAAATTCTTCCATTGGAAGGAAACAGTCTCCTCCTTTAAGCCTCGAGATATAC
CAAACATTATCTCCGCGAAAGATATCAAGAGATGAGGTGTCCCTAGAGGATTCCTCCCGAGGGGATTCGCCTGTAACTGTGGATGTGTCT
TGGGGTTCTCCCGACTGTGTAGGTCTGACAGAAACTAAGAGTATGATCTTCAGTCCTGCAAGCAAAGTGTACAATGGCATTTTGGAGAAA
TCCTGTAGCATGAACCAGCTTTCCAGTGGCATCCCGGTGCCTAAACCTCGCCACACATCATGTTCCTCAGCTGGCAACGACAGTAAACCA
GTTCAGGAAGCCCCAAGTGTTGCCAGAATAAGCAGCATCCCACATGACCTTTGTCATAATGGAGAGAAAAGCAAAAAGCCATCAAAAATC
AAAAGCCTTTTTAAGAAGAAATCTAAGTGAACTGGCTGACTTGATGGAATCATGTTCAAGTGGCATCTGTAAACTATTATCCCCCACCCT
CCACTCCCCACCTTTTTTTTGGTTTAATTTTAGGAATGTAACTCCATTGGGGCTTTCCAGGCCGGATGCCATAGTGGAACATCCAGAAGG
GCAACTGTCTACTGTCTGCTTATTTAAGTGACTATATATAATCAATTCATCAAGCCAGTTATTACTGAAAAATCATTGAAATGAGACAGT
TTACAGTCATTTCTGCCTATTTATTTCTGCTTTGTTCTCAGTGATGTATATGCAACATTTTGTTGAAAGCCACGATGGACTTACAAGCTT
TAATGGACTCGTAAGCCAGCATGGGCTTGCAAAAATTTCTTGTTTACCAGAGCATCTTCTTATCTTTCCACAGAGCTATTTACATCCTGG
ACTATATAACTTAAAAGAAGTAAAACGTAATTGCACTACTGTTTTCCAGACTGGAAAAAAAAAAAATCTCTGCAAGTGAAACTGTATAGA
GTTTATAAAATGACTATGGATAGGGGACTGTTTTCACTTTTAGATCAAAATGGGTTTTTAAGTAGAACCTAGGGTTTCTAATTGACTTGA
TTTCTGGAAATGAAAACCCGCGCTTTTATTATGGGAAGCTTCTTGAACTGCATTTACTATTGTGAAGTTTCAAGTCCCGCTGTAAAGATC
ATGTTGTTTTGTTTTCCCCAGGGCTTTCACTGTGATTTACTGCATTGCAGGCTGTATGATAAAACACACATAATTTAAAGAGAGAAGGCT
CTTGATTCCTTATGCAAGTGGAAGAGTTGAAACTTGATTGAAGGACTTAAAACATTCACAACCTTAAGCCGAGGTGGGGGGATATGGGGA
TTCAGGCAATTGTTTACACACTTTGAATAACTGCAAAGGATTTACGGTTTGTGAAAAATGTGTACTGTGGAAAAGATAATAAATTGAAGA
CATTATTGTGTGGGATTGTGCTGATTTTTGTTGATAACACAAAAAACACTATGTTTTCTGGAGAGCTGTGTAAGCTGTCTTGTTGCTTAG
TTGCAATATAAGAAATAGTGATGTTTTGGACGTAAGTTGTCAACAAATTTCTATTTTATATTGTTATATTTTTATGTAGTTTGAAATGTA
AAAATGTTCTAATATCAAGATTAACAAATATAAATTTATGGTGCATTTAGATTGCGTTGTATTAATTTATAAAGTATGGTGTTCATTAAA
TTGGTGGGTTGTATAAGGGTAGCTTTTGTTGTTAAAAAAACAGTAGAGAGTTAAGTTCCATATAGCAACAAAGTATGTTAACATCTAGGG
AGTTTCTGCTTATACCACTTTAAAAATATGCAATCATAAGTGATTTGGTTACTGCAATGCAGATGGATGTTTGGATGAACAACTGATACA
TTTTAGTTAGAATGCTTTTTCAGCATTATGGCTAAAATATATGTCTAACCCAGTGCTATTTAGGTGAAAATGCTAATTGATAAACCAGAA
GTTTCTTTTGAGATTTGCTTTAAAGAAATGCTTTAGTAAGAATATGAACAATTTCCTGATGTCTCCTATAAATTGTGATTGTTTATTCTA
TTACTATTGTTAAAAACTTGAATGGTATTTATATTGGCTGATATTTATATACTTAATAGATTGAGTTCTGTAAGGGCAAAAACGGATTGA
AATGAACATAGCGTTTTGCACTAATGATAAGATAACCTGAGAGGTAGGGTTGAGGAACACAGGGTTGAAAGCTGTTGGAGAGGGGAAAAG
TTGTGCATAAAGAACTGAAAAGGGTTCTGGAGTGTTCATTCAGAGTGAAGGGAAAACTTTATCCTTCTATTTCTTATAACCAGACAGGAG
GAGTTCTTCCCTTTGAAAATTGCAAAAGGAATGAGAACTTTGCAGTTGGATGAATAGAGAAGGGAAAAGTTGCTGGAGCACGGAGTGAAG
ATGGGAGGAGCTGTTAGCAAGGCCCACTGCTGCTCCTGGGTGAGAAGGGAGCTCTGGAGCAGGACCAGCTGGGGGCCGGCACTGCTGCTT
AGAGTGGAGGAGGCTGGCCAAAGAGACTGTGGGCTGTTTTCAGTCAGGGAGCATGTGCATTGTTTGTGCTCAATTTCAGACACTCATTTA
TAAACAAATTCAACCAAGGGATATTTACTGCTTTATGTTGCTTATGATAATTATTTTGCATTAATACAGTATACACATTTGTAAATTCAA
CAGGAAATTATTGAGTTTTGGAAAGCTACAGTAATTTCTGTATTACATCATTTATATGTGAAAAGTTGGACATTTCTGTAAGTTTTTAAA

>In-frame_ENST00000556285_ENST00000467087_TCGA-A1-A0SD-01A_TGFB3_chr14_76446885_-_STIM2_chr4_27024141_length(amino acids)=181AA_start in transcript=802_stop in transcript=257
MSLPAEEHDVWRGLGTGMPLESWFMLQDFSKMPLYTLLAGLKIILLVSVRPTQSGEPQDTSTVTGESPREESSRDTSSLDIFRGDNVWYI
SRLKGGDCFLPMEEFKESHSEAVSGTSCAPPAPGSCRIYGFLWHSIPTRCFPGCSLPPSPHASPPAAPGCCCKGPGPDRGRGSSPLAQGG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TGFB3-STIM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TGFB3-STIM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TGFB3-STIM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTGFB3C3810012RIENHOFF SYNDROME3GENOMICS_ENGLAND;UNIPROT
HgeneTGFB3C4707243Familial thoracic aortic aneurysm and aortic dissection3CLINGEN;GENOMICS_ENGLAND;ORPHANET
HgeneTGFB3C0008925Cleft Palate2CTD_human
HgeneTGFB3C1837218Cleft palate, isolated2CTD_human
HgeneTGFB3C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneTGFB3C0034067Pulmonary Emphysema1GENOMICS_ENGLAND
HgeneTGFB3C0035238Congenital abnormality of respiratory system1CTD_human
HgeneTGFB3C1862511ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 1 (disorder)1CTD_human;GENOMICS_ENGLAND
HgeneTGFB3C2697932Loeys-Dietz Syndrome1CTD_human;GENOMICS_ENGLAND
HgeneTGFB3C3711374Nonsyndromic Deafness1CTD_human
TgeneSTIM2C0043094Weight Gain1CTD_human