FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:TGFBR3-FGD3 (FusionGDB2 ID:89861)

Fusion Gene Summary for TGFBR3-FGD3

check button Fusion gene summary
Fusion gene informationFusion gene name: TGFBR3-FGD3
Fusion gene ID: 89861
HgeneTgene
Gene symbol

TGFBR3

FGD3

Gene ID

7049

89846

Gene nametransforming growth factor beta receptor 3FYVE, RhoGEF and PH domain containing 3
SynonymsBGCAN|betaglycanZFYVE5
Cytomap

1p22.1

9q22.31

Type of geneprotein-codingprotein-coding
Descriptiontransforming growth factor beta receptor type 3TGF-beta receptor type 3TGF-beta receptor type IIITGFR-3betaglycan proteoglycantransforming growth factor beta receptor IIIFYVE, RhoGEF and PH domain-containing protein 3FGD1 family, member 3faciogenital dysplasia 3zinc finger FYVE domain-containing protein 5
Modification date2020031320200313
UniProtAcc.

Q5JSP0

Ensembl transtripts involved in fusion geneENST00000212355, ENST00000370399, 
ENST00000525962, ENST00000468996, 
ENST00000375482, ENST00000416701, 
ENST00000468206, ENST00000337352, 
ENST00000538555, 
Fusion gene scores* DoF score14 X 13 X 6=10922 X 2 X 1=4
# samples 152
** MAII scorelog2(15/1092*10)=-2.86393845042397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: TGFBR3 [Title/Abstract] AND FGD3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTGFBR3(92262844)-FGD3(95765205), # samples:2
Anticipated loss of major functional domain due to fusion event.TGFBR3-FGD3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
TGFBR3-FGD3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTGFBR3

GO:0001837

epithelial to mesenchymal transition

18184661

HgeneTGFBR3

GO:0007179

transforming growth factor beta receptor signaling pathway

12958365

HgeneTGFBR3

GO:0030509

BMP signaling pathway

18184661

HgeneTGFBR3

GO:0032354

response to follicle-stimulating hormone

14557487

HgeneTGFBR3

GO:0034695

response to prostaglandin E

14557487

HgeneTGFBR3

GO:0034699

response to luteinizing hormone

14557487

HgeneTGFBR3

GO:0051271

negative regulation of cellular component movement

17999987

HgeneTGFBR3

GO:0060317

cardiac epithelial to mesenchymal transition

18184661


check buttonFusion gene breakpoints across TGFBR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FGD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABC032232TGFBR3chr1

92262844

-FGD3chr9

95765205

+
ChiTaRS5.0N/ABI834312TGFBR3chr1

92262844

-FGD3chr9

95765205

+


Top

Fusion Gene ORF analysis for TGFBR3-FGD3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000212355ENST00000375482TGFBR3chr1

92262844

-FGD3chr9

95765205

+
Frame-shiftENST00000212355ENST00000416701TGFBR3chr1

92262844

-FGD3chr9

95765205

+
5CDS-intronENST00000212355ENST00000468206TGFBR3chr1

92262844

-FGD3chr9

95765205

+
5CDS-intronENST00000212355ENST00000337352TGFBR3chr1

92262844

-FGD3chr9

95765205

+
5CDS-intronENST00000212355ENST00000538555TGFBR3chr1

92262844

-FGD3chr9

95765205

+
Frame-shiftENST00000370399ENST00000375482TGFBR3chr1

92262844

-FGD3chr9

95765205

+
Frame-shiftENST00000370399ENST00000416701TGFBR3chr1

92262844

-FGD3chr9

95765205

+
5CDS-intronENST00000370399ENST00000468206TGFBR3chr1

92262844

-FGD3chr9

95765205

+
5CDS-intronENST00000370399ENST00000337352TGFBR3chr1

92262844

-FGD3chr9

95765205

+
5CDS-intronENST00000370399ENST00000538555TGFBR3chr1

92262844

-FGD3chr9

95765205

+
In-frameENST00000525962ENST00000375482TGFBR3chr1

92262844

-FGD3chr9

95765205

+
In-frameENST00000525962ENST00000416701TGFBR3chr1

92262844

-FGD3chr9

95765205

+
5CDS-intronENST00000525962ENST00000468206TGFBR3chr1

92262844

-FGD3chr9

95765205

+
5CDS-intronENST00000525962ENST00000337352TGFBR3chr1

92262844

-FGD3chr9

95765205

+
5CDS-intronENST00000525962ENST00000538555TGFBR3chr1

92262844

-FGD3chr9

95765205

+
intron-3CDSENST00000468996ENST00000375482TGFBR3chr1

92262844

-FGD3chr9

95765205

+
intron-3CDSENST00000468996ENST00000416701TGFBR3chr1

92262844

-FGD3chr9

95765205

+
intron-intronENST00000468996ENST00000468206TGFBR3chr1

92262844

-FGD3chr9

95765205

+
intron-intronENST00000468996ENST00000337352TGFBR3chr1

92262844

-FGD3chr9

95765205

+
intron-intronENST00000468996ENST00000538555TGFBR3chr1

92262844

-FGD3chr9

95765205

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000525962TGFBR3chr192262844-ENST00000375482FGD3chr995765205+2680308622032656
ENST00000525962TGFBR3chr192262844-ENST00000416701FGD3chr995765205+2466308622029655

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000525962ENST00000375482TGFBR3chr192262844-FGD3chr995765205+0.039124530.96087545
ENST00000525962ENST00000416701TGFBR3chr192262844-FGD3chr995765205+0.0450433380.9549567

Top

Fusion Genomic Features for TGFBR3-FGD3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TGFBR3chr192262843-FGD3chr995765206+7.89E-091
TGFBR3chr192262843-FGD3chr995765206+7.89E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for TGFBR3-FGD3


check button Go to

FGviewer for the breakpoints of chr1:92262844-chr9:95765205

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FGD3

Q5JSP0

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFGD3chr1:92262844chr9:95765205ENST00000337352218157_341151.0726.0DomainDH
TgeneFGD3chr1:92262844chr9:95765205ENST00000337352218370_469151.0726.0DomainPH 1
TgeneFGD3chr1:92262844chr9:95765205ENST00000337352218604_703151.0726.0DomainPH 2
TgeneFGD3chr1:92262844chr9:95765205ENST00000375482218157_341151.0726.0DomainDH
TgeneFGD3chr1:92262844chr9:95765205ENST00000375482218370_469151.0726.0DomainPH 1
TgeneFGD3chr1:92262844chr9:95765205ENST00000375482218604_703151.0726.0DomainPH 2
TgeneFGD3chr1:92262844chr9:95765205ENST00000337352218532_588151.0726.0Zinc fingerFYVE-type
TgeneFGD3chr1:92262844chr9:95765205ENST00000375482218532_588151.0726.0Zinc fingerFYVE-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTGFBR3chr1:92262844chr9:95765205ENST00000212355-317455_73082.0852.0DomainZP
HgeneTGFBR3chr1:92262844chr9:95765205ENST00000370399-418455_73082.0851.0DomainZP
HgeneTGFBR3chr1:92262844chr9:95765205ENST00000525962-216455_73082.0852.0DomainZP
HgeneTGFBR3chr1:92262844chr9:95765205ENST00000212355-31721_78782.0852.0Topological domainExtracellular
HgeneTGFBR3chr1:92262844chr9:95765205ENST00000212355-317810_85182.0852.0Topological domainCytoplasmic
HgeneTGFBR3chr1:92262844chr9:95765205ENST00000370399-41821_78782.0851.0Topological domainExtracellular
HgeneTGFBR3chr1:92262844chr9:95765205ENST00000370399-418810_85182.0851.0Topological domainCytoplasmic
HgeneTGFBR3chr1:92262844chr9:95765205ENST00000525962-21621_78782.0852.0Topological domainExtracellular
HgeneTGFBR3chr1:92262844chr9:95765205ENST00000525962-216810_85182.0852.0Topological domainCytoplasmic
HgeneTGFBR3chr1:92262844chr9:95765205ENST00000212355-317788_80982.0852.0TransmembraneHelical
HgeneTGFBR3chr1:92262844chr9:95765205ENST00000370399-418788_80982.0851.0TransmembraneHelical
HgeneTGFBR3chr1:92262844chr9:95765205ENST00000525962-216788_80982.0852.0TransmembraneHelical


Top

Fusion Gene Sequence for TGFBR3-FGD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000525962_ENST00000375482_BC032232_TGFBR3_chr1_92262844_-_FGD3_chr9_95765205_length(transcript)=2680nt_BP=308nt
GATTGTCTGTGCTCTGAGCAGGCTGAAGTGACTGGACGAGACGCACTGTTGGAGAAATAAAAATGACTTCCCATTATGTGATTGCCATCT
TTGCCCTGATGAGCTCCTGTTTAGCCACTGCAGGTCCAGAGCCTGGTGCACTGTGTGAACTGTCACCTGTCAGTGCCTCCCATCCTGTCC
AGGCCTTGATGGAGAGCTTCACTGTTTTGTCAGGCTGTGCCAGCAGAGGCACAACTGGGCTGCCACAGGAGGTGCATGTCCTGAATCTCC
GCACTGCAGGCCAGGGGCCTGGCCAGCTACAGAGAGAGCACTCTGGCCCCCAGAAGCTTCTCCACATTGCCCAGGAGCTCCTGCACACCG
AGGAGACCTATGTGAAGCGGCTGCACCTGCTGGACCAGGTTTTCTGCACCAGGCTGACGGATGCGGGGATCCCTCCAGAAGTCATCATGG
GCATATTCTCTAACATCTCCTCCATCCACCGCTTCCACGGGCAGTTCCTGCTGCCGGAGCTGAAGACGCGGATCACGGAGGAGTGGGACA
CAAACCCACGGCTCGGGGACATCCTGCAGAAGCTGGCCCCATTCCTGAAGATGTACGGCGAGTATGTCAAGAACTTTGACCGAGCCGTAG
GGCTGGTGAGCACGTGGACCCAGCGCTCCCCACTGTTTAAAGACGTCGTCCACAGCATCCAGAAGCAGGAGGTATGCGGGAACCTGACGC
TGCAGCACCACATGCTGGAGCCCGTGCAGAGGGTCCCCCGGTACGAGCTGCTGCTCAAGGACTATCTGAAGAGGCTCCCGCAGGACGCCC
CAGACCGGAAGGATGCGGAGAGGTCCTTGGAGCTCATCTCCACAGCCGCCAACCACTCCAATGCTGCCATTCGGAAAGTGGAGAAAATGC
ACAAGCTCTTGGAGGTGTACGAGCAGCTGGGTGGGGAAGAAGACATTGTCAACCCGGCCAATGAACTGATCAAGGAGGGCCAAATCCAGA
AACTGTCAGCCAAGAACGGCACCCCCCAGGACCGCCACCTCTTCCTGTTCAACAGCATGATCCTTTACTGTGTGCCCAAGCTGCGGCTCA
TGGGCCAGAAGTTCAGCGTCCGGGAGAAGATGGACATCTCAGGCCTCCAGGTGCAGGATATCGTCAAGCCAAACACAGCACATACATTCA
TCATAACAGGAAGAAAAAGGTCCCTGGAGCTGCAGACGCGGACAGAGGAAGAGAAGAAAGAATGGATTCAGATCATCCAGGCCACCATCG
AGAAGCACAAACAGAACAGCGAAACCTTCAAGGCTTTTGGTGGCGCCTTCAGCCAGGATGAGGACCCCAGCCTCTCTCCAGACATGCCTA
TCACGAGCACCAGCCCTGTGGAGCCTGTGGTGACCACCGAAGGCAGTTCGGGTGCAGCAGGGCTCGAGCCCAGAAAACTATCCTCTAAGA
CCAGACGTGACAAGGAGAAGCAGAGCTGTAAGAGCTGTGGTGAGACCTTCAACTCCATCACCAAGAGGAGGCATCACTGCAAGCTGTGTG
GGGCGGTCATCTGTGGGAAGTGCTCCGAGTTCAAGGCCGAGAACAGCCGGCAGAGCCGTGTCTGCAGAGATTGTTTCCTGACACAGCCAG
TGGCCCCTGAGAGCACAGAGAAGACACCCACTGCAGACCCCCAGCCCAGCCTGCTCTGCGGCCCCCTGCGGCTGTCAGAGAGCGGTGAGA
CCTGGAGCGAGGTGTGGGCCGCCATCCCCATGTCAGATCCCCAGGTGCTGCACCTGCAGGGAGGCAGCCAGGACGGCCGGCTGCCCCGCA
CCATCCCTCTCCCCAGCTGCAAACTGAGTGTGCCGGACCCTGAGGAGAGGCTGGACTCGGGGCATGTGTGGAAGCTGCAGTGGGCCAAGC
AGTCCTGGTACCTGAGCGCCTCCTCCGCAGAGCTGCAGCAGCAGTGGCTGGAAACCCTAAGCACTGCTGCCCATGGGGACACGGCCCAGG
ACAGCCCGGGGGCCCTGCAGCTTCAGGTCCCTATGGGCGCAGCTGCTCCGTGAGCTGAGTCTCCCACTGCCCTGCACACCACCACATTGG
ACCTGTGCTGTCCTGGGAGGTGGTGTTGGAGGCCCCATGAAGAGCGCCCTGGACTGCTGAGGGTGGGCCAACAGCCCAGAGCTCAGGACA
CTTGGCTTTGGGGGGAAGGAAACTGAGGCCCAGAGAGGGGCAACCACTGGCCAAGGGTCACCCAGCAAGTTTTGGCTAAGAGCCTGGCCT
CCAGCCCCAGCAGTGTGGCCCAGAGCAGGGGCCGACTGCCAAAGTAACCATCATCCATATGGGCCGTGTGGTGATGCTGGCCCGGAAGGC
AGAAAGAGGCAGCATGGGCACTGCCAGGGACAGCCACATCCTGCTGGTCTGCAGCGTGGTCCACCCCGCCTCTGCCCAGCCTGTCTACAC
CGTGTGAGCTGAATCGTGACTTGCTTCCCACCTCCTTTCTCTGTCCTCTCCTGAGGTTCTGCCTGCAGCCCCCAGGAGGTGGGCCTGCCC
CATCCTAGCTGGACTCATGGTTCCTAAATAACCACGCTCAGAAGCTCTGCTAGGACTTACCCCAGCCACTGAGTGGCAGGCGCATGAGAT

>In-frame_ENST00000525962_ENST00000375482_BC032232_TGFBR3_chr1_92262844_-_FGD3_chr9_95765205_length(amino acids)=656AA_start in transcript=62_stop in transcript=2032
MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREHSGPQKLL
HIAQELLHTEETYVKRLHLLDQVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDILQKLAPFLKMYGE
YVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSN
AAIRKVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFSVREKMDISGLQVQDI
VKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEKHKQNSETFKAFGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAG
LEPRKLSSKTRRDKEKQSCKSCGETFNSITKRRHHCKLCGAVICGKCSEFKAENSRQSRVCRDCFLTQPVAPESTEKTPTADPQPSLLCG
PLRLSESGETWSEVWAAIPMSDPQVLHLQGGSQDGRLPRTIPLPSCKLSVPDPEERLDSGHVWKLQWAKQSWYLSASSAELQQQWLETLS

--------------------------------------------------------------
>In-frame_ENST00000525962_ENST00000416701_BC032232_TGFBR3_chr1_92262844_-_FGD3_chr9_95765205_length(transcript)=2466nt_BP=308nt
GATTGTCTGTGCTCTGAGCAGGCTGAAGTGACTGGACGAGACGCACTGTTGGAGAAATAAAAATGACTTCCCATTATGTGATTGCCATCT
TTGCCCTGATGAGCTCCTGTTTAGCCACTGCAGGTCCAGAGCCTGGTGCACTGTGTGAACTGTCACCTGTCAGTGCCTCCCATCCTGTCC
AGGCCTTGATGGAGAGCTTCACTGTTTTGTCAGGCTGTGCCAGCAGAGGCACAACTGGGCTGCCACAGGAGGTGCATGTCCTGAATCTCC
GCACTGCAGGCCAGGGGCCTGGCCAGCTACAGAGAGAGCACTCTGGCCCCCAGAAGCTTCTCCACATTGCCCAGGAGCTCCTGCACACCG
AGGAGACCTATGTGAAGCGGCTGCACCTGCTGGACCAGGTTTTCTGCACCAGGCTGACGGATGCGGGGATCCCTCCAGAAGTCATCATGG
GCATATTCTCTAACATCTCCTCCATCCACCGCTTCCACGGGCAGTTCCTGCTGCCGGAGCTGAAGACGCGGATCACGGAGGAGTGGGACA
CAAACCCACGGCTCGGGGACATCCTGCAGAAGCTGGCCCCATTCCTGAAGATGTACGGCGAGTATGTCAAGAACTTTGACCGAGCCGTAG
GGCTGGTGAGCACGTGGACCCAGCGCTCCCCACTGTTTAAAGACGTCGTCCACAGCATCCAGAAGCAGGAGGTATGCGGGAACCTGACGC
TGCAGCACCACATGCTGGAGCCCGTGCAGAGGGTCCCCCGGTACGAGCTGCTGCTCAAGGACTATCTGAAGAGGCTCCCGCAGGACGCCC
CAGACCGGAAGGATGCGGAGAGGTCCTTGGAGCTCATCTCCACAGCCGCCAACCACTCCAATGCTGCCATTCGGAAAGTGGAGAAAATGC
ACAAGCTCTTGGAGGTGTACGAGCAGCTGGGTGGGGAAGAAGACATTGTCAACCCGGCCAATGAACTGATCAAGGAGGGCCAAATCCAGA
AACTGTCAGCCAAGAACGGCACCCCCCAGGACCGCCACCTCTTCCTGTTCAACAGCATGATCCTTTACTGTGTGCCCAAGCTGCGGCTCA
TGGGCCAGAAGTTCAGCGTCCGGGAGAAGATGGACATCTCAGGCCTCCAGGTGCAGGATATCGTCAAGCCAAACACAGCACATACATTCA
TCATAACAGGAAGAAAAAGGTCCCTGGAGCTGCAGACGCGGACAGAGGAAGAGAAGAAAGAATGGATTCAGATCATCCAGGCCACCATCG
AGAAGCACAAACAGAACAGCGAAACCTTCAAGGCTTTTGGTGGCGCCTTCAGCCAGGATGAGGACCCCAGCCTCTCTCCAGACATGCCTA
TCACGAGCACCAGCCCTGTGGAGCCTGTGGTGACCACCGAAGGCAGTTCGGGTGCAGCAGGGCTCGAGCCCAGAAAACTATCCTCTAAGA
CCAGACGTGACAAGGAGAAGCAGAGCTGTAAGAGCTGTGGTGAGACCTTCAACTCCATCACCAAGAGGAGGCATCACTGCAAGCTGTGTG
GGGCGGTCATCTGTGGGAAGTGCTCCGAGTTCAAGGCCGAGAACAGCCGGCAGAGCCGTGTCTGCAGAGATTGTTTCCTGACACAGCCAG
TGGCCCCTGAGAGCACAGAGACACCCACTGCAGACCCCCAGCCCAGCCTGCTCTGCGGCCCCCTGCGGCTGTCAGAGAGCGGTGAGACCT
GGAGCGAGGTGTGGGCCGCCATCCCCATGTCAGATCCCCAGGTGCTGCACCTGCAGGGAGGCAGCCAGGACGGCCGGCTGCCCCGCACCA
TCCCTCTCCCCAGCTGCAAACTGAGTGTGCCGGACCCTGAGGAGAGGCTGGACTCGGGGCATGTGTGGAAGCTGCAGTGGGCCAAGCAGT
CCTGGTACCTGAGCGCCTCCTCCGCAGAGCTGCAGCAGCAGTGGCTGGAAACCCTAAGCACTGCTGCCCATGGGGACACGGCCCAGGACA
GCCCGGGGGCCCTGCAGCTTCAGGTCCCTATGGGCGCAGCTGCTCCGTGAGCTGAGTCTCCCACTGCCCTGCACACCACCACATTGGACC
TGTGCTGTCCTGGGAGGTGGTGTTGGAGGCCCCATGAAGAGCGCCCTGGACTGCTGAGGGTGGGCCAACAGCCCAGAGCTCAGGACACTT
GGCTTTGGGGGGAAGGAAACTGAGGCCCAGAGAGGGGCAACCACTGGCCAAGGGTCACCCAGCAAGTTTTGGCTAAGAGCCTGGCCTCCA
GCCCCAGCAGTGTGGCCCAGAGCAGGGGCCGACTGCCAAAGTAACCATCATCCATATGGGCCGTGTGGTGATGCTGGCCCGGAAGGCAGA
AAGAGGCAGCATGGGCACTGCCAGGGACAGCCACATCCTGCTGGTCTGCAGCGTGGTCCACCCCGCCTCTGCCCAGCCTGTCTACACCGT

>In-frame_ENST00000525962_ENST00000416701_BC032232_TGFBR3_chr1_92262844_-_FGD3_chr9_95765205_length(amino acids)=655AA_start in transcript=62_stop in transcript=2029
MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREHSGPQKLL
HIAQELLHTEETYVKRLHLLDQVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDILQKLAPFLKMYGE
YVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSN
AAIRKVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFSVREKMDISGLQVQDI
VKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEKHKQNSETFKAFGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAG
LEPRKLSSKTRRDKEKQSCKSCGETFNSITKRRHHCKLCGAVICGKCSEFKAENSRQSRVCRDCFLTQPVAPESTETPTADPQPSLLCGP
LRLSESGETWSEVWAAIPMSDPQVLHLQGGSQDGRLPRTIPLPSCKLSVPDPEERLDSGHVWKLQWAKQSWYLSASSAELQQQWLETLST

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TGFBR3-FGD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTGFBR3chr1:92262844chr9:95765205ENST00000212355-317737_75182.0852.0TGF-beta ligand
HgeneTGFBR3chr1:92262844chr9:95765205ENST00000370399-418737_75182.0851.0TGF-beta ligand
HgeneTGFBR3chr1:92262844chr9:95765205ENST00000525962-216737_75182.0852.0TGF-beta ligand


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for TGFBR3-FGD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for TGFBR3-FGD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTGFBR3C1862932ANEURYSM, INTRACRANIAL BERRY, 1 (disorder)1ORPHANET