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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TGFBR3-SH3GLB1 (FusionGDB2 ID:89869)

Fusion Gene Summary for TGFBR3-SH3GLB1

check button Fusion gene summary
Fusion gene informationFusion gene name: TGFBR3-SH3GLB1
Fusion gene ID: 89869
HgeneTgene
Gene symbol

TGFBR3

SH3GLB1

Gene ID

7049

51100

Gene nametransforming growth factor beta receptor 3SH3 domain containing GRB2 like, endophilin B1
SynonymsBGCAN|betaglycanBif-1|CGI-61|PPP1R70|dJ612B15.2
Cytomap

1p22.1

1p22.3

Type of geneprotein-codingprotein-coding
Descriptiontransforming growth factor beta receptor type 3TGF-beta receptor type 3TGF-beta receptor type IIITGFR-3betaglycan proteoglycantransforming growth factor beta receptor IIIendophilin-B1Bax-interacting factor 1SH3 domain-containing GRB2-like protein B1SH3-containing protein SH3GLB1SH3-domain GRB2 like endophilin B1protein phosphatase 1, regulatory subunit 70testicular tissue protein Li 172
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000212355, ENST00000370399, 
ENST00000525962, ENST00000468996, 
ENST00000370558, ENST00000535010, 
ENST00000482504, 
Fusion gene scores* DoF score14 X 13 X 6=10924 X 4 X 3=48
# samples 154
** MAII scorelog2(15/1092*10)=-2.86393845042397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TGFBR3 [Title/Abstract] AND SH3GLB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTGFBR3(92262844)-SH3GLB1(87181407), # samples:1
Anticipated loss of major functional domain due to fusion event.TGFBR3-SH3GLB1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
TGFBR3-SH3GLB1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TGFBR3-SH3GLB1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
TGFBR3-SH3GLB1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTGFBR3

GO:0001837

epithelial to mesenchymal transition

18184661

HgeneTGFBR3

GO:0007179

transforming growth factor beta receptor signaling pathway

12958365

HgeneTGFBR3

GO:0030509

BMP signaling pathway

18184661

HgeneTGFBR3

GO:0032354

response to follicle-stimulating hormone

14557487

HgeneTGFBR3

GO:0034695

response to prostaglandin E

14557487

HgeneTGFBR3

GO:0034699

response to luteinizing hormone

14557487

HgeneTGFBR3

GO:0051271

negative regulation of cellular component movement

17999987

HgeneTGFBR3

GO:0060317

cardiac epithelial to mesenchymal transition

18184661

TgeneSH3GLB1

GO:0031334

positive regulation of protein complex assembly

19074440


check buttonFusion gene breakpoints across TGFBR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SH3GLB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8530-01ATGFBR3chr1

92262844

-SH3GLB1chr1

87181407

+


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Fusion Gene ORF analysis for TGFBR3-SH3GLB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000212355ENST00000370558TGFBR3chr1

92262844

-SH3GLB1chr1

87181407

+
5CDS-intronENST00000212355ENST00000535010TGFBR3chr1

92262844

-SH3GLB1chr1

87181407

+
5CDS-intronENST00000212355ENST00000482504TGFBR3chr1

92262844

-SH3GLB1chr1

87181407

+
Frame-shiftENST00000370399ENST00000370558TGFBR3chr1

92262844

-SH3GLB1chr1

87181407

+
5CDS-intronENST00000370399ENST00000535010TGFBR3chr1

92262844

-SH3GLB1chr1

87181407

+
5CDS-intronENST00000370399ENST00000482504TGFBR3chr1

92262844

-SH3GLB1chr1

87181407

+
In-frameENST00000525962ENST00000370558TGFBR3chr1

92262844

-SH3GLB1chr1

87181407

+
5CDS-intronENST00000525962ENST00000535010TGFBR3chr1

92262844

-SH3GLB1chr1

87181407

+
5CDS-intronENST00000525962ENST00000482504TGFBR3chr1

92262844

-SH3GLB1chr1

87181407

+
intron-3CDSENST00000468996ENST00000370558TGFBR3chr1

92262844

-SH3GLB1chr1

87181407

+
intron-intronENST00000468996ENST00000535010TGFBR3chr1

92262844

-SH3GLB1chr1

87181407

+
intron-intronENST00000468996ENST00000482504TGFBR3chr1

92262844

-SH3GLB1chr1

87181407

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000525962TGFBR3chr192262844-ENST00000370558SH3GLB1chr187181407+6283308621333423

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000525962ENST00000370558TGFBR3chr192262844-SH3GLB1chr187181407+0.0001494180.9998505

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Fusion Genomic Features for TGFBR3-SH3GLB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TGFBR3chr192262843-SH3GLB1chr187181406+0.0003335730.99966645
TGFBR3chr192262843-SH3GLB1chr187181406+0.0003335730.99966645

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TGFBR3-SH3GLB1


check button Go to

FGviewer for the breakpoints of chr1:92262844-chr1:87181407

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSH3GLB1chr1:92262844chr1:87181407ENST0000037055809155_19524.0366.0Coiled coilOntology_term=ECO:0000255
TgeneSH3GLB1chr1:92262844chr1:87181407ENST00000482504011155_19524.0387.0Coiled coilOntology_term=ECO:0000255
TgeneSH3GLB1chr1:92262844chr1:87181407ENST0000053501008155_1950266.0Coiled coilOntology_term=ECO:0000255
TgeneSH3GLB1chr1:92262844chr1:87181407ENST000003705580927_26124.0366.0DomainBAR
TgeneSH3GLB1chr1:92262844chr1:87181407ENST0000037055809305_36524.0366.0DomainSH3
TgeneSH3GLB1chr1:92262844chr1:87181407ENST0000048250401127_26124.0387.0DomainBAR
TgeneSH3GLB1chr1:92262844chr1:87181407ENST00000482504011305_36524.0387.0DomainSH3
TgeneSH3GLB1chr1:92262844chr1:87181407ENST000005350100827_2610266.0DomainBAR
TgeneSH3GLB1chr1:92262844chr1:87181407ENST0000053501008305_3650266.0DomainSH3
TgeneSH3GLB1chr1:92262844chr1:87181407ENST00000535010081_300266.0RegionNote=Membrane-binding amphipathic helix
TgeneSH3GLB1chr1:92262844chr1:87181407ENST00000535010081_370266.0RegionRequired for membrane binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTGFBR3chr1:92262844chr1:87181407ENST00000212355-317455_73082.0852.0DomainZP
HgeneTGFBR3chr1:92262844chr1:87181407ENST00000370399-418455_73082.0851.0DomainZP
HgeneTGFBR3chr1:92262844chr1:87181407ENST00000525962-216455_73082.0852.0DomainZP
HgeneTGFBR3chr1:92262844chr1:87181407ENST00000212355-31721_78782.0852.0Topological domainExtracellular
HgeneTGFBR3chr1:92262844chr1:87181407ENST00000212355-317810_85182.0852.0Topological domainCytoplasmic
HgeneTGFBR3chr1:92262844chr1:87181407ENST00000370399-41821_78782.0851.0Topological domainExtracellular
HgeneTGFBR3chr1:92262844chr1:87181407ENST00000370399-418810_85182.0851.0Topological domainCytoplasmic
HgeneTGFBR3chr1:92262844chr1:87181407ENST00000525962-21621_78782.0852.0Topological domainExtracellular
HgeneTGFBR3chr1:92262844chr1:87181407ENST00000525962-216810_85182.0852.0Topological domainCytoplasmic
HgeneTGFBR3chr1:92262844chr1:87181407ENST00000212355-317788_80982.0852.0TransmembraneHelical
HgeneTGFBR3chr1:92262844chr1:87181407ENST00000370399-418788_80982.0851.0TransmembraneHelical
HgeneTGFBR3chr1:92262844chr1:87181407ENST00000525962-216788_80982.0852.0TransmembraneHelical
TgeneSH3GLB1chr1:92262844chr1:87181407ENST00000370558091_3024.0366.0RegionNote=Membrane-binding amphipathic helix
TgeneSH3GLB1chr1:92262844chr1:87181407ENST00000370558091_3724.0366.0RegionRequired for membrane binding
TgeneSH3GLB1chr1:92262844chr1:87181407ENST000004825040111_3024.0387.0RegionNote=Membrane-binding amphipathic helix
TgeneSH3GLB1chr1:92262844chr1:87181407ENST000004825040111_3724.0387.0RegionRequired for membrane binding


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Fusion Gene Sequence for TGFBR3-SH3GLB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000525962_ENST00000370558_TCGA-CD-8530-01A_TGFBR3_chr1_92262844_-_SH3GLB1_chr1_87181407_length(transcript)=6283nt_BP=308nt
GATTGTCTGTGCTCTGAGCAGGCTGAAGTGACTGGACGAGACGCACTGTTGGAGAAATAAAAATGACTTCCCATTATGTGATTGCCATCT
TTGCCCTGATGAGCTCCTGTTTAGCCACTGCAGGTCCAGAGCCTGGTGCACTGTGTGAACTGTCACCTGTCAGTGCCTCCCATCCTGTCC
AGGCCTTGATGGAGAGCTTCACTGTTTTGTCAGGCTGTGCCAGCAGAGGCACAACTGGGCTGCCACAGGAGGTGCATGTCCTGAATCTCC
GCACTGCAGGCCAGGGGCCTGGCCAGCTACAGAGAGAGTTCACAGAAGAAAAGCTTGGCCAGGCTGAGAAGACAGAATTGGATGCTCACT
TAGAGAACCTCCTTAGCAAAGCTGAATGTACCAAAATATGGACAGAAAAAATAATGAAACAAACTGAAGTGTTATTGCAGCCAAATCCAA
ATGCCAGGATAGAAGAATTTGTTTATGAGAAACTGGATAGAAAAGCTCCAAGTCGTATAAACAACCCAGAACTTTTGGGACAATATATGA
TTGATGCAGGGACTGAGTTTGGCCCAGGAACAGCTTATGGTAATGCCCTTATTAAATGTGGAGAAACCCAAAAAAGAATTGGAACAGCAG
ACAGAGAACTGATTCAAACGTCAGCCTTAAATTTTCTTACTCCTTTAAGAAACTTTATAGAAGGAGATTACAAAACAATTGCTAAAGAAA
GGAAACTATTGCAAAATAAGAGACTGGATTTGGATGCTGCAAAAACGAGACTAAAAAAGGCAAAAGCTGCAGAAACTAGAAATTCATCTG
AACAGGAATTAAGAATAACTCAAAGTGAATTTGATCGTCAAGCAGAGATTACCAGACTTCTGCTAGAGGGAATCAGCAGTACACATGCCC
ATCACCTTCGCTGTCTGAATGACTTTGTAGAAGCCCAGATGACTTACTATGCACAGTGTTACCAGTATATGTTGGACCTCCAGAAACAAC
TGGGAAGTTTTCCATCCAATTATCTTAGTAACAACAATCAGACTTCTGTGACACCTGTACCATCAGTTTTACCAAATGCGATTGGTTCTT
CTGCCATGGCTTCAACAAGTGGCCTAGTAATCACCTCTCCTTCCAACCTCAGTGACCTTAAGGAGTGTAGTGGCAGCAGAAAGGCCAGGG
TTCTCTATGATTATGATGCAGCAAACAGTACTGAATTATCACTTCTGGCAGATGAGGTGATCACTGTGTTCAGTGTTGTTGGAATGGATT
CAGACTGGCTAATGGGGGAAAGGGGAAACCAGAAGGGCAAGGTGCCAATTACCTACTTAGAACTGCTCAATTAAGTAGGTGGACTATGGA
AAGGTTGCCCATCATGACTTTGTATTTATATACAATTAACTCTAAATAAAGCAGGTTAAGTATCTTCCATGTTAATGTGTTAAGAGACTG
AAAATACCAGCCATCAGAAACTGGCCTTTCTGCCAATAAAGTTGCATGGTAAATATTTCATTACAGAATTTATGTTAGAGCTTTCATGCC
AAGAATGTTTTCTTACAAAATTCTCTTTTTATTGAGGTTTCACTAATAAGCAGCTTCTACTTTTGAGCCTCAACTTAAAGCAGAACTGTT
TTCTACTGGATTTTTCATTAACAGCAAGCTTTTTCTTTTATGTAAAATAAATCTATTGTGAATTGATATCAGCGACTCATTTATTAGGTA
TAAATAATAGCCAAAGAATAAAATTAAAATTTATTTTAAACTTTCGGTCTTAAAAAGAGCTGTAGGATATAAACCTCTTTTGTGAAAAGT
AGAATTTTCTGAATGCTTTCATAGACAAAAACGCATTTAAACTATGTTTACCTGGTTTTCCAACAGAAATCAAATGATTTTAATATTATG
TTTTGATGGGTTATTTTCAGAGTTGTTTGGTTTTTTAAACACTACTGAATGGTTTCTTTTAAATTTAAGAACAACTAGTTCTTGAAAAGC
AATACCGTATTTCTCTGATAAATTTGTAGTTAAGGTTCTAGAAAATCTAGGACAAATTTACTTCATTAAACATAAAGTTTTTAAGATTAT
TCAGTTGGCACAATTTAATGCATAATTGGGATTGGATCCATTTACTGTACTGTGGTACAGTAAAGAGAATGTGTTCTTATTGAACAGCAG
ATTTGTATACAAATACGGAATAATGCAACTACATTATAAATTGTATACGAACAAAATAAATTGGGTCACTCTGAGCTTACTATTAAAACA
TTGAAAATTTATTAATGAACACAGGCTATCTTGATGAGGATCTCTGCTTATGAAACACATACTAATGAAATTATTAGTGACACATTGGAA
GCTAGAAAATTGCTGTTGGGGCCATTGCTATAAATCATTGTTTCCATGTTAAGACTTCTGTTCTAATTCATTCATTCAACAAACATTTGT
TGAGGGCCAGATACTGTGCTGGTCAACTGGGGATACTGTCCTGAACAATATGCACACAGTTCTTGCCCCTGCAGAGCTTAAAGACCATTA
AAGGATACAGAAAATTAAGCAATTATCCTATAGTAGGATTCGTGGTGTGATGGGGAAAATACAAGGTACTGTATTTGGGAGTCATGTAAC
TCCAGTTTTGGGAGTGAGAGAGGGTCTGGGGAAGAACTGTTCCAGATAAAAAGATGTGTAACCAAGATAGCATAGCACATTCTGACAACT
AAAGCAATTTACTCTAACTTAAGCATGAAGTACAAAAGTATAGTTCATTTATTGAGGGAATGTTAAGCTATTAAAATGATACTTTTTGGT
ACTTTTAAAAAAATGAATACTTAAACACCGTTTTAAAATTTTGTGTTAAGAGCTCCTAATAAGAACTTGGTAAACATGTTGACAATTTAA
CTCACAGTCTAAACTTTAAAAGTAGTAGTTACCCTTTTATTTCTGTGCCATGAGACAAATTCTTCTGCAGTTTTATAGTTGTACAAGATG
TTTTGACTCACTCTCAATTGCCATATTCTTAAAGAAACCCTGAAAAGCTGCTCAAGCTGGTCAGTTTTCTGTAAAACCAAGTAAATGAAA
TTTTCTCTCCCCTCAGAAAGGAAGTTCTACAGCCTAGAGTACCATCTATTGTGTTTTATAAGTCCAGATTTAGGCTTTGAAAGATCATAC
CAAAACTTCAGATCGACTTAAACAGCAACTATGAATTAGGTTTATGGGAAATGTAGTAATACAGGGGAAAGAATATCGGTAATGGAGTGA
AATGGTCCTGGGTTCAAATCCAGTCTTCCTCACATATTGTGCTCTTTAAGCTTCAAATGAGATGTATAACTGCCTTTTCCTTACCAGTAA
AATGAGGACAATAATTATGACACCATAGGGTGGTTGTGAGGATTAGCAAATGTTATCTTGTATTTCAGGTGCCTTTCAGGGAAAGGCTTG
GCACATAGTAAACACATCCTGTAAATATCAGTTTCCCCTTGTTAGCCCCTGTAGCATCCTGACCTACCAAGTCTATAGGCCTTGCATATC
ACTGTGCACCAGAGATACCTCTTTTACATCTGGGCTCTGTTTTCTCTCTATCAATCCTATCCTCCACCCTCTTTAAATCAGACCCCAGGT
TTAACCTTCCCACAGTCAGTATAAATCATTTTTCAGAACTTTCAGCTTTCCATCAAGTGAAAGTTGATTTTAGTTACCCAGTAATGTACA
GAAACCTTCAATAATGTTAAGCTTCAAAGGCTTCTGGTACGTTTGTCTACCACAGAACCACCACAATATATATGCTTGTTCTTAGGTTTA
TTGCTTTTTATTTTAATGGGGTTTGGTTGTTTGGGTTTTATTTTGGTTTTGGCTTATTTTAAAGTCAAGTTTAGTTTTTACTCAGGTAAA
GGCCTGAAGTTTCTTGGGCGTGGAAGAAAAAGCTTGGGAAGCCTATTAATTCATGGTGCAGTTCAGAATTGTTTAAATAAGCTCTGTGCC
ACTGAGCTTAATCTGAAAGTATAGTGACATGTGAAGGATGCACATATGAATGAAAAACTAAAATAATTGTAGGCTCTTCTATAAATGAAA
AAAAAAGTGATTGGATTGTGTCTACCTTTTTCCTCAAAGTAATCTAACCTAAACGGTCATGGTGTTAAAACTTTTTATGGTGCTAATCAG
AAAAATTGATGTTGCAAGAAATGAGGTCTCAAAAATGGGAATGTGCCTCCTCACTCTGCGTCACATGGGAAATAAATCCTGAGGCCAGGA
TCACCAGTGGGGTAGAGTCATCTTCATAGTCTCCTGTTATCCTCCCCCTGAACAAAGAACAAAGTGAGACTGGGAAGCTAGTGTTGGGGA
AACATTTCTGGGATAAACTGTGGAGTGGAGAAGACAATGGAGGGCAAGGCAAAAACCCACAGACTTGTTTACCCATAGAGGCCCCACTCA
CCTCCATGCTGACAGAATTCCAGAAAAATTCCTTCCCTATCTCCCAAACACCTGAAATTCTGAAATATTGCCCTACTATTTAGCACTTTA
AGCTTCAGTGAGGTGCTGTAATGGAGAGATAGCTTCATAGTTTAGCCTATAGCCAACTTTGCCTCAAGACCTCCAGATAAGATGAAGTGG
CTTTTACCTCATGTGAGTCTCAAACGCTGGAGAGAGAGTTCCACAACCACCCCTGCCCTTTCTCCCATATTACGCTCATTAGAAAGTCTA
CTCAGGGCTGGGTGCCGTGGCTCATGCCTGTAATCCCAGCACTTTGGAGGCTGAGGCGGGTGGATCATCTGAGGTCAGGAGTTCGAGACC
AGCCTGGCCAACATGGGGAAACCCTGTCTCTACTGAAAATATAAAAATTAGCCGGGCATGGTGGCGTGCACCTGTAATTCCAGCTACTCG
GGAGGCTGAGGCAGGAGAATCACTTGAACCCCAGAGGCAGAGGCTACAGTGAGCCAAGATTGCACCACTGCACTCCAACCTGGGTGATAG
AATAAGACTCTTGTCTCAAGGAAAGAAAAAATGTCTACTCAGTAGAGCAGTGATTGGCAAAGTGTGAGACCCCAGACCGGCAATATTGGC
ATCTCCTGGAGACTTGTTTAAAATGCTGATTACTATTTTCAAGAACTTTCTACCTTCATTTTTACTTATTTTTTGTTTTCAAGGGCTCAT
GGAATCAGTCTTCCATGTGACAGCTTTTTAAATATTTTAAGACAAAAACTGAGTCTTCTAATCTTAATTGTGTTCTAGCAGTAGTCATTG
TAATTATAGTTATTTTTATAATTTATTTGTTTAGTGTATATCTGTCACTCTAGAATGTAGGCTCCCTGAGATAAAAACTATAATTCTTTT
GATGGCAGTTACATTCCCAACTCTTAGCACAAGATCTAGGACATAGTATGAACTCAATAAATTTTTGTTGAATGAAAGAAAAATGCAAAT
TTATAAGCCTTTTCAGAGACCTACTGAATCAAACTCTGAGAGTGGAGCCCAGCAATCTGTTGTAAAAGCTGTTTGAGTAATACTGTTGCA
CTCTAAGCTTGAGAACCACTGCAATAGAACTAAGAGAACATTCATTTCACCTTCAGGCCTATTCTCTGACATCACTTGAAAAATCCTCTC
TGCCTTCTGTAACCCTTAACCAACAACAGTGCCCTGTCCATGTAGGGGAAACTTCTGGGCTGTATTACAAGTGGGTAGGAAGGTATAAGG
ATATCATAGTGGGAAGTATTGCTTAGAATGCCAGTACTTGTTTGCTGTGGAAGGTTTCTAGGAATGGATTGCTTAGTCTAAAGTAAGCAC
TACCACCATCCACGTTTTCACTCAACACAGTGCCTTTTAATTGGTGACTAACATCAAAACACCTTGACAAACCGTTAAAACAGTATCAGA
AACCATGTGTACATCCCTGTGCCTCTTAGATTGCTAAGTTCTGCTCTCATTCTTACTTCAAAGGACACTTTTTAAAGAATTGTTAATGCT
TTTTTATAATACAAGTCATAGCCCTGTTGGCAAAAAGAAAAAAGATTCAGTGAGAAAGAAAAATCACTGATAATTCCATCATCCAGGGAG
AACCACTGTTATTTAAGTATATGGCCTTCCAGACTTTTCTGTGCATTTATAGATATTTTTAATGGGATCAAAGTGTACATACTGTTTTGT
AACTTTTTTTCACTCAACAATACCATGACTGTCTTGCTGTGTCAAGTATATTTCTACATCTCTTAATGGCTGCATGATATTCCATCATAT

>In-frame_ENST00000525962_ENST00000370558_TCGA-CD-8530-01A_TGFBR3_chr1_92262844_-_SH3GLB1_chr1_87181407_length(amino acids)=423AA_start in transcript=62_stop in transcript=1333
MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREFTEEKLGQ
AEKTELDAHLENLLSKAECTKIWTEKIMKQTEVLLQPNPNARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCG
ETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSSEQELRITQSEFDRQAEITRLL
LEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYLSNNNQTSVTPVPSVLPNAIGSSAMASTSGLVITSPSNLSDLK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TGFBR3-SH3GLB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTGFBR3chr1:92262844chr1:87181407ENST00000212355-317737_75182.0852.0TGF-beta ligand
HgeneTGFBR3chr1:92262844chr1:87181407ENST00000370399-418737_75182.0851.0TGF-beta ligand
HgeneTGFBR3chr1:92262844chr1:87181407ENST00000525962-216737_75182.0852.0TGF-beta ligand


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TGFBR3-SH3GLB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TGFBR3-SH3GLB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTGFBR3C1862932ANEURYSM, INTRACRANIAL BERRY, 1 (disorder)1ORPHANET