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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TGM2-TGM2 (FusionGDB2 ID:89905)

Fusion Gene Summary for TGM2-TGM2

check button Fusion gene summary
Fusion gene informationFusion gene name: TGM2-TGM2
Fusion gene ID: 89905
HgeneTgene
Gene symbol

TGM2

TGM2

Gene ID

7052

7052

Gene nametransglutaminase 2transglutaminase 2
SynonymsTG(C)|TGCTG(C)|TGC
Cytomap

20q11.23

20q11.23

Type of geneprotein-codingprotein-coding
Descriptionprotein-glutamine gamma-glutamyltransferase 2C polypeptide, protein-glutamine-gamma-glutamyltransferaseTGase CTGase HTGase-2tissue transglutaminasetransglutaminase Ctransglutaminase Hprotein-glutamine gamma-glutamyltransferase 2C polypeptide, protein-glutamine-gamma-glutamyltransferaseTGase CTGase HTGase-2tissue transglutaminasetransglutaminase Ctransglutaminase H
Modification date2020032020200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000361475, ENST00000536701, 
ENST00000536724, 		ENST00000361475, 
ENST00000536701, ENST00000536724, 
Fusion gene scores* DoF score11 X 11 X 4=4849 X 11 X 5=495
# samples 1311
** MAII scorelog2(13/484*10)=-1.89649542424614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/495*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TGM2 [Title/Abstract] AND TGM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTGM2(36757373)-TGM2(36769717), # samples:1
TGM2(36775269)-TGM2(36779416), # samples:1
TGM2(36757747)-TGM2(36784488), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTGM2

GO:0018149

peptide cross-linking

30458214

HgeneTGM2

GO:0043277

apoptotic cell clearance

19628791

TgeneTGM2

GO:0018149

peptide cross-linking

30458214

TgeneTGM2

GO:0043277

apoptotic cell clearance

19628791


check buttonFusion gene breakpoints across TGM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TGM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA345479TGM2chr20

36757373

-TGM2chr20

36769717

-
ChiTaRS5.0N/ABF748178TGM2chr20

36775269

+TGM2chr20

36779416

-
ChiTaRS5.0N/ABP287181TGM2chr20

36757747

-TGM2chr20

36784488

-


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Fusion Gene ORF analysis for TGM2-TGM2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000361475ENST00000361475TGM2chr20

36757373

-TGM2chr20

36769717

-
intron-3CDSENST00000361475ENST00000536701TGM2chr20

36757373

-TGM2chr20

36769717

-
intron-3CDSENST00000361475ENST00000536724TGM2chr20

36757373

-TGM2chr20

36769717

-
intron-3CDSENST00000536701ENST00000361475TGM2chr20

36757373

-TGM2chr20

36769717

-
intron-3CDSENST00000536701ENST00000536701TGM2chr20

36757373

-TGM2chr20

36769717

-
intron-3CDSENST00000536701ENST00000536724TGM2chr20

36757373

-TGM2chr20

36769717

-
intron-3CDSENST00000536724ENST00000361475TGM2chr20

36757373

-TGM2chr20

36769717

-
intron-3CDSENST00000536724ENST00000536701TGM2chr20

36757373

-TGM2chr20

36769717

-
intron-3CDSENST00000536724ENST00000536724TGM2chr20

36757373

-TGM2chr20

36769717

-
intron-3CDSENST00000361475ENST00000361475TGM2chr20

36775269

+TGM2chr20

36779416

-
intron-3CDSENST00000361475ENST00000536701TGM2chr20

36775269

+TGM2chr20

36779416

-
intron-3CDSENST00000361475ENST00000536724TGM2chr20

36775269

+TGM2chr20

36779416

-
intron-3CDSENST00000536701ENST00000361475TGM2chr20

36775269

+TGM2chr20

36779416

-
intron-3CDSENST00000536701ENST00000536701TGM2chr20

36775269

+TGM2chr20

36779416

-
intron-3CDSENST00000536701ENST00000536724TGM2chr20

36775269

+TGM2chr20

36779416

-
intron-3CDSENST00000536724ENST00000361475TGM2chr20

36775269

+TGM2chr20

36779416

-
intron-3CDSENST00000536724ENST00000536701TGM2chr20

36775269

+TGM2chr20

36779416

-
intron-3CDSENST00000536724ENST00000536724TGM2chr20

36775269

+TGM2chr20

36779416

-
intron-3CDSENST00000361475ENST00000361475TGM2chr20

36757747

-TGM2chr20

36784488

-
intron-intronENST00000361475ENST00000536701TGM2chr20

36757747

-TGM2chr20

36784488

-
intron-intronENST00000361475ENST00000536724TGM2chr20

36757747

-TGM2chr20

36784488

-
intron-3CDSENST00000536701ENST00000361475TGM2chr20

36757747

-TGM2chr20

36784488

-
intron-intronENST00000536701ENST00000536701TGM2chr20

36757747

-TGM2chr20

36784488

-
intron-intronENST00000536701ENST00000536724TGM2chr20

36757747

-TGM2chr20

36784488

-
intron-3CDSENST00000536724ENST00000361475TGM2chr20

36757747

-TGM2chr20

36784488

-
intron-intronENST00000536724ENST00000536701TGM2chr20

36757747

-TGM2chr20

36784488

-
intron-intronENST00000536724ENST00000536724TGM2chr20

36757747

-TGM2chr20

36784488

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TGM2-TGM2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TGM2-TGM2


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TGM2-TGM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TGM2-TGM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TGM2-TGM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TGM2-TGM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTGM2C0005586Bipolar Disorder2PSYGENET
HgeneTGM2C0017636Glioblastoma2CTD_human
HgeneTGM2C0036341Schizophrenia2PSYGENET
HgeneTGM2C0334588Giant Cell Glioblastoma2CTD_human
HgeneTGM2C1621958Glioblastoma Multiforme2CTD_human
HgeneTGM2C0006118Brain Neoplasms1CTD_human
HgeneTGM2C0006142Malignant neoplasm of breast1CTD_human
HgeneTGM2C0007134Renal Cell Carcinoma1CTD_human
HgeneTGM2C0007570Celiac Disease1CTD_human
HgeneTGM2C0014859Esophageal Neoplasms1CTD_human
HgeneTGM2C0020538Hypertensive disease1CTD_human
HgeneTGM2C0029408Degenerative polyarthritis1CTD_human
HgeneTGM2C0030297Pancreatic Neoplasm1CTD_human
HgeneTGM2C0086743Osteoarthrosis Deformans1CTD_human
HgeneTGM2C0153633Malignant neoplasm of brain1CTD_human
HgeneTGM2C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneTGM2C0346647Malignant neoplasm of pancreas1CTD_human
HgeneTGM2C0496899Benign neoplasm of brain, unspecified1CTD_human
HgeneTGM2C0546837Malignant neoplasm of esophagus1CTD_human
HgeneTGM2C0678222Breast Carcinoma1CTD_human
HgeneTGM2C0750974Brain Tumor, Primary1CTD_human
HgeneTGM2C0750977Recurrent Brain Neoplasm1CTD_human
HgeneTGM2C0750979Primary malignant neoplasm of brain1CTD_human
HgeneTGM2C1257931Mammary Neoplasms, Human1CTD_human
HgeneTGM2C1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneTGM2C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneTGM2C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneTGM2C1306837Papillary Renal Cell Carcinoma1CTD_human
HgeneTGM2C1458155Mammary Neoplasms1CTD_human
HgeneTGM2C1527390Neoplasms, Intracranial1CTD_human
HgeneTGM2C4704874Mammary Carcinoma, Human1CTD_human
TgeneTGM2C0005586Bipolar Disorder2PSYGENET
TgeneTGM2C0017636Glioblastoma2CTD_human
TgeneTGM2C0036341Schizophrenia2PSYGENET
TgeneTGM2C0334588Giant Cell Glioblastoma2CTD_human
TgeneTGM2C1621958Glioblastoma Multiforme2CTD_human
TgeneTGM2C0006118Brain Neoplasms1CTD_human
TgeneTGM2C0006142Malignant neoplasm of breast1CTD_human
TgeneTGM2C0007134Renal Cell Carcinoma1CTD_human
TgeneTGM2C0007570Celiac Disease1CTD_human
TgeneTGM2C0014859Esophageal Neoplasms1CTD_human
TgeneTGM2C0020538Hypertensive disease1CTD_human
TgeneTGM2C0029408Degenerative polyarthritis1CTD_human
TgeneTGM2C0030297Pancreatic Neoplasm1CTD_human
TgeneTGM2C0086743Osteoarthrosis Deformans1CTD_human
TgeneTGM2C0153633Malignant neoplasm of brain1CTD_human
TgeneTGM2C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneTGM2C0346647Malignant neoplasm of pancreas1CTD_human
TgeneTGM2C0496899Benign neoplasm of brain, unspecified1CTD_human
TgeneTGM2C0546837Malignant neoplasm of esophagus1CTD_human
TgeneTGM2C0678222Breast Carcinoma1CTD_human
TgeneTGM2C0750974Brain Tumor, Primary1CTD_human
TgeneTGM2C0750977Recurrent Brain Neoplasm1CTD_human
TgeneTGM2C0750979Primary malignant neoplasm of brain1CTD_human
TgeneTGM2C1257931Mammary Neoplasms, Human1CTD_human
TgeneTGM2C1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneTGM2C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneTGM2C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneTGM2C1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneTGM2C1458155Mammary Neoplasms1CTD_human
TgeneTGM2C1527390Neoplasms, Intracranial1CTD_human
TgeneTGM2C4704874Mammary Carcinoma, Human1CTD_human