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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TGM6-GRIK3 (FusionGDB2 ID:89912)

Fusion Gene Summary for TGM6-GRIK3

check button Fusion gene summary
Fusion gene informationFusion gene name: TGM6-GRIK3
Fusion gene ID: 89912
HgeneTgene
Gene symbol

TGM6

GRIK3

Gene ID

343641

2899

Gene nametransglutaminase 6glutamate ionotropic receptor kainate type subunit 3
SynonymsSCA35|TG6|TGM3L|TGY|dJ734P14.3EAA5|GLR7|GLUR7|GluK3|GluR7a
Cytomap

20p13

1p34.3

Type of geneprotein-codingprotein-coding
Descriptionprotein-glutamine gamma-glutamyltransferase 6TGase YTGase-6transglutaminase yglutamate receptor ionotropic, kainate 3dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7))excitatory amino acid receptor 5gluR-7glutamate receptor 7
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000202625, ENST00000381423, 
ENST00000477505, 		ENST00000373091, 
ENST00000373093, ENST00000462621, 
Fusion gene scores* DoF score2 X 1 X 1=25 X 4 X 2=40
# samples 15
** MAII scorelog2(1/2*10)=2.32192809488736log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TGM6 [Title/Abstract] AND GRIK3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTGM6(2398219)-GRIK3(37282878), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGRIK3

GO:0007215

glutamate receptor signaling pathway

7719709

TgeneGRIK3

GO:0007216

G protein-coupled glutamate receptor signaling pathway

9144652

TgeneGRIK3

GO:0042391

regulation of membrane potential

11124978


check buttonFusion gene breakpoints across TGM6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GRIK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-IC-A6RF-11ATGM6chr20

2398219

+GRIK3chr1

37282878

-
ChimerDB4Non-CancerTCGA-IC-A6RF-11ATGM6chr20

2398219

+GRIK3chr1

37282878

-


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Fusion Gene ORF analysis for TGM6-GRIK3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000202625ENST00000373091TGM6chr20

2398219

+GRIK3chr1

37282878

-
In-frameENST00000202625ENST00000373093TGM6chr20

2398219

+GRIK3chr1

37282878

-
5CDS-intronENST00000202625ENST00000462621TGM6chr20

2398219

+GRIK3chr1

37282878

-
In-frameENST00000381423ENST00000373091TGM6chr20

2398219

+GRIK3chr1

37282878

-
In-frameENST00000381423ENST00000373093TGM6chr20

2398219

+GRIK3chr1

37282878

-
5CDS-intronENST00000381423ENST00000462621TGM6chr20

2398219

+GRIK3chr1

37282878

-
intron-3CDSENST00000477505ENST00000373091TGM6chr20

2398219

+GRIK3chr1

37282878

-
intron-3CDSENST00000477505ENST00000373093TGM6chr20

2398219

+GRIK3chr1

37282878

-
intron-intronENST00000477505ENST00000462621TGM6chr20

2398219

+GRIK3chr1

37282878

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000202625TGM6chr202398219+ENST00000373091GRIK3chr137282878-89501739612625854
ENST00000202625TGM6chr202398219+ENST00000373093GRIK3chr137282878-28001739612484807
ENST00000381423TGM6chr202398219+ENST00000373091GRIK3chr137282878-89501739612625854
ENST00000381423TGM6chr202398219+ENST00000373093GRIK3chr137282878-28001739612484807

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000202625ENST00000373091TGM6chr202398219+GRIK3chr137282878-0.0030265920.9969734
ENST00000202625ENST00000373093TGM6chr202398219+GRIK3chr137282878-0.0076139250.9923861
ENST00000381423ENST00000373091TGM6chr202398219+GRIK3chr137282878-0.0030265920.9969734
ENST00000381423ENST00000373093TGM6chr202398219+GRIK3chr137282878-0.0076139250.9923861

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Fusion Genomic Features for TGM6-GRIK3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TGM6-GRIK3


check button Go to

FGviewer for the breakpoints of chr20:2398219-chr1:37282878

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGRIK3chr20:2398219chr1:37282878ENST000003730911116690_692624.3333333333334920.0RegionGlutamate binding
TgeneGRIK3chr20:2398219chr1:37282878ENST000003730911116658_820624.3333333333334920.0Topological domainExtracellular
TgeneGRIK3chr20:2398219chr1:37282878ENST000003730911116842_919624.3333333333334920.0Topological domainCytoplasmic
TgeneGRIK3chr20:2398219chr1:37282878ENST000003730911116637_657624.3333333333334920.0TransmembraneHelical
TgeneGRIK3chr20:2398219chr1:37282878ENST000003730911116821_841624.3333333333334920.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGRIK3chr20:2398219chr1:37282878ENST00000373091111632_563624.3333333333334920.0Topological domainExtracellular
TgeneGRIK3chr20:2398219chr1:37282878ENST000003730911116585_636624.3333333333334920.0Topological domainCytoplasmic
TgeneGRIK3chr20:2398219chr1:37282878ENST000003730911116564_584624.3333333333334920.0TransmembraneHelical


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Fusion Gene Sequence for TGM6-GRIK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000202625_ENST00000373091_TCGA-IC-A6RF-11A_TGM6_chr20_2398219_+_GRIK3_chr1_37282878_length(transcript)=8950nt_BP=1739nt
ACTGTCCTGACGGTGCACACACTGCTGTGTGGAGGAACAGAGGAGTCCAGCTGGCCTTCACATGGCAGGGATCAGAGTCACCAAGGTGGA
CTGGCAGCGGTCGAGGAATGGCGCTGCCCACCACACCCAGGAGTACCCCTGCCCTGAGCTGGTGGTTCGCAGGGGCCAGTCGTTCAGCCT
CACGCTGGAGCTGAGCAGAGCCCTGGACTGTGAGGAGATCCTCATCTTCACGATGGAGACAGGACCCCGGGCTTCTGAGGCCCTCCACAC
CAAAGCTGTGTTCCAGACATCGGAGCTGGAGCGGGGTGAGGGCTGGACAGCAGCAAGGGAGGCTCAGATGGAGAAAACTCTGACCGTCAG
TCTCGCCAGCCCTCCCAGTGCTGTCATTGGCCGCTACCTGCTGAGCATCAGGCTTTCCTCTCACCGCAAACACAGCAACCGGAGGCTGGG
CGAGTTTGTTCTCCTTTTCAACCCATGGTGTGCAGAGGACGATGTGTTTCTGGCCTCAGAGGAGGAGAGACAGGAGTACGTGCTCAGCGA
CAGCGGCATCATCTTCCGAGGCGTGGAGAAGCACATACGAGCCCAGGGCTGGAACTACGGGCAGTTTGAGGAGGACATCCTGAACATCTG
CCTCTCCATCCTGGATCGAAGCCCCGGTCACCAAAACAACCCAGCCACCGACGTGTCCTGCCGCCACAACCCCATCTACGTCACCAGGGT
CATCAGTGCCATGGTGAACAGCAACAACGACCGAGGTGTGGTGCAAGGACAGTGGCAGGGCAAGTACGGCGGCGGCACCAGCCCGCTGCA
CTGGCGCGGCAGCGTGGCCATTCTGCAGAAGTGGCTCAAGGGCAGGTACAAGCCAGTCAAGTACGGCCAGTGCTGGGTCTTCGCCGGAGT
CCTGTGCACAGTCCTCAGGTGCTTGGGGATAGCCACACGGGTCGTGTCCAACTTCAACTCAGCCCACGACACAGACCAGAACCTGAGTGT
GGACAAATACGTGGACTCCTTCGGGCGGACCCTGGAGGACCTGACAGAAGACAGCATGTGGAATTTCCATGTCTGGAATGAGAGCTGGTT
TGCCCGGCAGGACCTAGGCCCCTCTTACAATGGCTGGCAGGTTCTGGATGCCACCCCCCAGGAGGAGAGTGAAGGTGTGTTCCGGTGCGG
CCCAGCCTCAGTCACCGCCATCCGCGAGGGTGATGTGCACCTGGCTCACGATGGCCCCTTCGTGTTTGCGGAGGTCAACGCCGACTACAT
CACCTGGCTGTGGCACGAGGATGAGAGCCGGGAGCGTGTATACTCAAACACGAAGAAGATTGGGAGATGCATCAGCACCAAGGCGGTGGG
CAGTGACTCCCGCGTGGACATCACTGACCTCTACAAGTATCCGGAAGGGTCCCGGAAAGAGAGGCAGGTGTACAGCAAGGCGGTGAACAG
GCTGTTCGGCGTGGAAGCCTCTGGAAGGAGAATCTGGATCCGCAGGGCTGGGGGTCGCTGTCTCTGGCGTGACGACCTCCTGGAGCCTGC
CACCAAGCCCAGCATCGCTGGCAAGTTCAAGGTGCTAGAGCCTCCCATGCTGGGCCACGACCTGAGACTGGCCCTGTGCTTGGCCAACCT
CACCTCCCGGGCCCAGCGGGTGAGGGTCAACCTGAGCGGTGCCACCATCCTCTATACCCGCAAGCCAGTGGCAGAGATCCTGCATGAATC
CCACGCCGTGAGGCTGGGGCCGCAAGAAGGGTCTGAGCTGATGCCCAAAGCCCTGTCCACACGCATCATTGGTGGCATCTGGTGGTTCTT
CACGCTCATCATCATCTCTTCCTACACGGCCAACCTGGCTGCCTTTCTGACCGTGGAGCGCATGGAATCACCCATTGACTCTGCTGATGA
CCTGGCCAAGCAAACCAAAATCGAGTATGGGGCTGTCAAGGATGGGGCCACCATGACCTTCTTCAAGAAATCCAAGATCTCCACCTTCGA
GAAGATGTGGGCCTTCATGAGCAGCAAGCCATCGGCGCTGGTGAAGAACAACGAGGAGGGCATCCAGAGGGCCCTGACGGCCGACTACGC
GCTGCTCATGGAGTCCACCACCATCGAGTACGTCACGCAGAGGAACTGCAACCTCACCCAGATCGGGGGCCTCATTGACTCCAAGGGCTA
CGGCATCGGCACGCCCATGGGCTCCCCATACCGGGACAAGATCACCATCGCCATCCTGCAGCTTCAGGAGGAGGACAAGCTGCATATCAT
GAAGGAGAAGTGGTGGCGGGGCAGCGGGTGTCCTGAGGAGGAAAACAAAGAGGCCAGTGCCCTGGGGATCCAGAAGATCGGGGGCATCTT
CATTGTCCTGGCCGCCGGGCTGGTCCTCTCTGTGCTGGTGGCCGTGGGCGAGTTTGTGTACAAGCTCCGCAAAACAGCAGAGAGAGAGCA
GCGTTCCTTCTGCAGCACCGTGGCCGATGAGATCCGTTTCTCCCTTACCTGCCAGCGTCGAGTCAAGCACAAGCCTCAGCCTCCCATGAT
GGTCAAGACTGACGCCGTCATCAACATGCACACATTCAATGACCGCCGGCTTCCCGGCAAGGACAGCATGGCCTGCAGCACATCCTTAGC
CCCTGTGTTCCCCTAGGCACAGCTGGGGTGGGGACCTCAGGCCTGGGGGCTGGGCAGAGGAAAGCAAAGGAGATTGGAAGGAACGTCCCC
TGTCCCCGCACTGGGCTTGGGGACCAGAGCTGCCACCTGCCTGTTGGGCCAGGAGCCTCCTGCCCTTACCTGCCAGGAAGCCAGCAGGCT
CTCAGGCCAGCTGCTTGGGCTTCATCCTCCTCAGATCTTCTGTGGGTTTCTAAAGCTGCCAGCCGAGATAGCCAAGGCCAAAGGAAGCAC
ATGCCTCTCTCAGGCCAAACTCACCTGCCCCTCAACTCTCCTCCAGAGTCAGAAGTTTCTGCCGCAGCCCTGCAGAGGGCACAGAAAATG
GAAGACAGCTCTTATATTGCCATTTCTTCCACAAGAGCCCAGGCCTCCTACAGCTTGACCGTGAGGCCAGAGACACAAGCCTTCGGCGCC
TTAAGGATGTTCTAGCATGGCTGCCAATGGGAGCTCATGGTGAGGGATACCCATCCCATATGCCTGGGCAGAAGGAAGACTTCATCCCTC
TGGGGCTGTTCACGTGGTCCTAATCTTCTGAACTTGGCGCTGCCCCTGGCAGCCCCTGTTCTGGCAGAGTTGAAGACAGAGCTACACAGG
GGAAAAGAGGAGTTTGGGGTATGGGAGAGAAGAGAATGCACAAACAGAGGCCGCCATTTTGGATTCTTATGGACAATGACCCAGTGGTTC
CTAATCCTCTAGGAGGTCTCTAAGAATATAAGTGGGGGAGTGGCCACAGAAAATTCTTCTCCACTTTCTAGCCAGAGGAGAGAGGACCCC
CTGAATTTCTCACAAAGGATGCCCAAAGATGCAGCCGGTATTTGAAGCCCAGCAGAGGAAAAGCAGATTCCATGGAAGTCCCACCGGCTC
TTGTGCCAATGGATCTCACTTTCCTGGTTAGCAAGCTGTTGTCTAAACCCTGTTCACATTTGGAAACCTGGGCTCTTTGCCATCTTCTCA
TCAACAACTCCCCATTCCTGGCTGGTTGACCTTGGCCTCACTCTGTCTTTTTGAAAGAAGAGTTGGTTGAAGTGAAAGTCAAGTTGTCCC
TCCTCAAAAAAGGAGTTAGTGTCCTACTACACAGACTAACTTTGGGCTAGGTGAGGGAAACCAGAAGAGACCAAAAGAACTTCTGGTCTC
CTGGACTTACCAAACCTAGAGATGCTCCCCAGGAAAAGAAAGTTTCCAGGGACATAATATCATAGCTGGCAGAGGCCCCAAGGGTGGGGA
GGAAGAAGCTGCCTCCTGGAGAATTAACCAAAGACCCCACACAGAGACATGAGGCCATCCTGGCCCCTTGTCTGTTGTCCAGAGCAGCTA
TGGCATTGTGGGGCTTGGGGAAGACAGCAGAGAAGTAGCAGCAGGTTGGGTACCAGCCAGGGGGTGGACCTATGAGTTCCAGCTTGCTGT
GATGAATGCTCTAGAGGTCTGTGACTTTAAGAGTCTTGGAAAAGAATGAGACATGAAGGATTAGGAACAAAGTGTCCTTAAAGAGAACAT
GATGGGCCAGCAGGGTTACCATGGCCAAGGATGGAGGGGCAGGTTTTGAACAGGGGAGGGAGGTTCTGGGGATTCTGGATGAGAACTGGG
GCATACCAGCCACTCCCCTCCCACCTCTGTCCCATGCTGCTTGGGAAGCCCGGTTAGGGAAGAGCTTCATTTGGATCTCAAGGGCTTTCT
CATCTGGGTGAAGGGCAATCTCTAGCAAAGCAGGAGACCACAGTGGGCTCATGTGATAAACACTGTCCCTCCTCCAGACTGTGAGCTGCA
GGACCAAACCAGCAGGTTCCCAGAATCCTAGCAGCTCTGACTGGCTATGTACATTGGACGAGGGAGAGGAGGGCTAGACATACACCAAAG
CCCCATGCATGTAATGTTAGGAAAAGCCATGCTGTCATAAGCTTCAGGGTACAGAGGGCGTGTGCATGTGTGTCTGTGTCTTTGTGTTTG
TATGTGTGAGCTTCGGGGGCTGGGGCACAGGACAGATCTGGACATATAACATAGTCCAGGGCATGCAATAATAGGTGAATCCTTGGGGAT
CTGATGTGTGCATATGCGTGCGTATGTGTATCTGAGTGAATTGGGGACGAGGGAGACAAATATGTGAAGCAGCAAGGCCCCATATATGTA
AAAACAGGAGAAGCCATGTCATAATGGGGCCCTGGTGGGTATGCATATGTAAGCATGCATGCATGCATAGGTGTGTGCATGCTGGTGTGT
GTGTGTGCACATGTACACTGAATGGCATAGGATGGAGATCAGGATCTTACCTGCAGCTAGCCAAATATGCGTAAAAGGAGAAGCCATGTC
ACCAAGGGGTCCATGTCTGAGTGCATGTGAACACATGTGTACAGGCATGTGTGCACAGTGGGGAGCGGGGGGAAGGCCAGGACCAGAGAG
TCGTGTGACATGGGTCAATGCATGCTGTAGACAAGAAGCCACGTGGAGTTGAAGTTTCCGAGTGTGTGGGACACACACATATGTTCCAGG
TCACAGTGGAAGCAAAGACAGACAATCAGGAAGGCCGGGCACCAGGGTCTGTTTGCACTTCTGTCATGGGAGAGATCATTTGTCACAGAG
AGGTTCCAAGGTTGCATGGGCACACTTGCCAGGAGACGGGGGCACAACCCTTCAGGGGCTCATGCTGCTGATGCCTTTGCTGTGGACATC
ATGTCCTGTTTGAAGGGAAAACTCTTTTTTGTAATTCCCAGGTAACAGGATTCTAATGAAGGTATTTGCCAATTTGCTGTCAGCAAACAC
AATCATTAAGCGCCGTCTTACTTTGTCCAGTATAGTTTCAGAGCACGTGCCTCATTCTTGCTCTTGTCTCACACATGTGTTGTGTGTGTG
ATGCTACATGAGCATGTTCTTCAGAGGCTATGCATATATGTGGATTGTGACAGGAGGAAGAAGAAGTGGTGAGAATTTTTATAAAACGAA
CAAAGAATAGTGGATAAATAGAGGCAGAATTCAATTCGAGAAACCCCCCAAAATGTACCGACTGGTCTTTAGACTCCTGTGTGGAAGCAG
GAGGGCATGCTGCCTCATCTCCTCTCCCAGGCAAACCTTGCGTCCTGATGTTCAGGTGTTGTCGGTGTGGCTGATATTTGGCTTCTGGCC
AATATCCTGCATTTGTCCTAGAGACCAGCCTAGTGTTCAAAGTGCAGTGGGGACCACAGCTGCCCAAGCATGAGCTCTGTCTCTCCCGGG
GCACTGAAAATGATGCTACATCTGTGAGGTGGGACGGAGTGGGGAGGTGTTTTCAGTGAGGCAGATCTTGTGTTTTTTTAAGTTTAGGTC
TGTCCTGCCAGTGGGCATGGAGCTGAGCTGGGGCAGGTGCATGCGTGTGTGTGTATGTGTGTGTATGCATGTGTAGTGTGTGTGCACACA
CGCAGGCACTGAGAGGTGATGGGAAGCATGAAAGCTTGCTTGGATGGAGCAGAAGAAGGAACCTGCCTGAGCAGATGCTGGACTGTCCCT
GCGTGGTGCCACATGCCAGCCCTGAACAGAAGAATGTCCCCACTGCATCCCCAAATGCAAGTGCCTCCTCTCCACCTGCTCAAGCTGGCC
AAGTTGAGGGGCAGTGGTAAGAAGACACCAACCCCACCGCCCCTGCCGAGGCCCTGGGACTAAGGACAGTGAGCCCTCCCAATCACTCTC
CCCTTGTCCTGCTGCTGGTTTCTCTGCTCTGGACAGAAGAAAATCCTGAAAGCGTTGTCAATGTTCAAGTGGCCCCATGCTGCAAGAGTC
TCTCGCGAGGGGTGACGCCCCCTTGGCCAGTGTGCTGGACTTTGAGTGTCTGAGGGGTAAGAGGGCCACCCCCTCCTCACAGCCGAGACT
CTATCTAACCTGGAAGCACACTCTGGCTCCACCCCCAACCCCTGCCATGCCCTAGGCCCTGGAAGATGGGAATCCTGGCCCAGGCCAGGG
TAAAGGGCCAAACAGGTTAGAAGTTGCTCCCCTCCACCAGGCGTGCACTCACCAAGAACGATCAAAAGCTCCCTTTCTGCCTACTTTTCC
AGGGGTACTGGGTGTGGGGGGTGGGTCACAGCTCCTGCTTCATCACTCAGCATGAAGTTGGTCCCTCCCTGAGCCACTCCCAGCTACATG
CACAAACATCTGAAAGTAGGCTGGCCTCTCTGGCTCACATCTGGAGTGGTCCTGTGTGGATACCCATCTGCAAAGGGGCTAGAGGTTTGG
ACAAACAGCTGCATGGACTTATCATCTGGGATGGGCCCAGCCTCATGGACAGATACAAGAAATGAGCCCAACTCTGTGGGCAGGTCTCTG
GATTAGACACATCTGAAAGTTGCAGGTCAAGTGGACACATCTGGAAGTGGCCCGGCTGCTGGCTGCCATGGAAGGGCCGTGCCCTCTGTC
CCCATGGCAGTTTAAATCAGGCCTTCCCTTCAGTCCTGGATTTGCCCTGGAGTAAAAATTTCAGAGCTGAGGTCATACGTGAGTCACAAA
ACTTTTAGGTAGAAGGTTAATGTTCTGTACAATATATATATGAATGTAAAATATATATATATACTGTATATATATATATATATGCACAGT
GTATATATGACCTGTAGCCCATGTGTATACAACCCTTTCCTGCACGTCTGCACACGGAGTGTACAGAACCCAGCCAGCACGGGTGAGGAC
CAGATGAGAGATGGGGGCTGCAGCAGCAAAGTCTGGGACGGAGGTCTCAGAGAGCCCCTTGGGGTGGCGAAGGCCCTCCACACATCAGAG
CTCCAGACCCTGAAGAAGAGGGCAGAGCTACATGGTGCTGCCAGGTGAGTCCTGCACCGCCAGGGCCTCCTGTGGGAGGGGCAGGAATGG
CCAACGGACCTCATCTCCATCCGAGCCTGTCTGAGGCAGGACAGCTGGGTGTGTCTGAGAAGCAATGTCATGCTAGTACTCAGCCCCTGT
GCCAATATTACATTCTAGTTCTGGGGCAATTCATCAGGAGCAGAAGGGCTGGGAAAGAGCAGGCCACTCCCCAGGCCTGTTCTCACACCT
GCCTGCAGAATCACAGGTAGGTTTCAGGCTCCATCTAGGATACCCTAGAAGGCGGGGCTATTCTAGGTAGCAAAAGCCTCTGCCTCTGAT
TCTCACCCACATGCAGAAGCAGTCACAACTTGCACACAACACAGCTCACAACTAGGGAAAGCACTTGTTAAAGAGAATGCCCCCAGGGCA
TGGCCAGCATGCCGATACAGTGTTCCCATGCCCCTGTTACTGATCCTGTCCTCCTGCCTTCTAGAACAGTGGACCTCACATCACCTCCCA
GATTGTCTCCATTTTATGGATTGAAACTCTGAGGCCTCCAGACATGAAGAAGCAGCCATAGATTCAGTCAAATGCCAGCCAAGGGTTTGC
CTTGCCTCAGACAACCTCCCCAGCCCCATTTGACCCAGAGACCAGCTGTCAGGGAGCGACCTCAGAGCCAGAGGGGTGAAAGATGAGAGG
CAAGAAGGTAGCTCCTATCCTAGCACAGCCCAGGCTCCATCTGTCTGCCTTTCTCTCCCCTGCGGCATCCTGGCAGGGCAGTTGGCAGAG
TGCCCCCTCCCCAGGAGGCTGCAGATCTCTGTCCCTGGCTCACCCAGATCGGTCTGTTCTCTGCAGTTCCATTCCTTTAGCCTCTTTCGC
AGGTCTGAGCATCTCTGGAGCATGCAGGGGAGGAGATATCTGAGGTGGGCTTCCGTGCAGTCAGCAGCCTGCCCCAGCTTCAGCCTCAGG
CGTCAGGCTGGTCTGCACTGAACTCTGGGTCTGCCTCTGGGGCCCTGACCAAGCACGCCTGACTCCAGCCCCATGAGGAGCATCCTGTCT
TGGTTCCGTAGGGATCATGGGTCCTCTTACCACTGTGCGCCAAGCCCCCAGCCCACCTCTGCCTGGGCCGACTTCCTGGTTGGGCCTCCC
ATGGTAGGGGCCTCAGTTCCCAGGCTCTGGGCTGAGCCCCCAGGGAGCACCATGGGCCTCTGAGACCCTAGACCTGTCCCACCACCCAGA
CCAGAGTGCCTGGACGCCCCCCACTCCCACTCAACATGGTTCCCACACACTGGTCTCTGGGCCATTCAGGGGATGCCCTTTGTGGACATG
CAGAATTTCTATGAATATAGTTTTTTGTAAACATTTTGTAACAATTTGGGTTTCATAGTAACTGTGTTACTTGCCAATCATTCTAGGCTG
ATGTAAATAAATTTCCAAACAAATCTGATTATTTTCCTTTTTAAGACACTGTGATATATCAAAGTGCACAGTTTGCTGTATGAAGTAATA

>In-frame_ENST00000202625_ENST00000373091_TCGA-IC-A6RF-11A_TGM6_chr20_2398219_+_GRIK3_chr1_37282878_length(amino acids)=854AA_start in transcript=61_stop in transcript=2625
MAGIRVTKVDWQRSRNGAAHHTQEYPCPELVVRRGQSFSLTLELSRALDCEEILIFTMETGPRASEALHTKAVFQTSELERGEGWTAARE
AQMEKTLTVSLASPPSAVIGRYLLSIRLSSHRKHSNRRLGEFVLLFNPWCAEDDVFLASEEERQEYVLSDSGIIFRGVEKHIRAQGWNYG
QFEEDILNICLSILDRSPGHQNNPATDVSCRHNPIYVTRVISAMVNSNNDRGVVQGQWQGKYGGGTSPLHWRGSVAILQKWLKGRYKPVK
YGQCWVFAGVLCTVLRCLGIATRVVSNFNSAHDTDQNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARQDLGPSYNGWQVLDATPQ
EESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWHEDESRERVYSNTKKIGRCISTKAVGSDSRVDITDLYKYPEGSRKE
RQVYSKAVNRLFGVEASGRRIWIRRAGGRCLWRDDLLEPATKPSIAGKFKVLEPPMLGHDLRLALCLANLTSRAQRVRVNLSGATILYTR
KPVAEILHESHAVRLGPQEGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTF
FKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQ
LQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRR

--------------------------------------------------------------
>In-frame_ENST00000202625_ENST00000373093_TCGA-IC-A6RF-11A_TGM6_chr20_2398219_+_GRIK3_chr1_37282878_length(transcript)=2800nt_BP=1739nt
ACTGTCCTGACGGTGCACACACTGCTGTGTGGAGGAACAGAGGAGTCCAGCTGGCCTTCACATGGCAGGGATCAGAGTCACCAAGGTGGA
CTGGCAGCGGTCGAGGAATGGCGCTGCCCACCACACCCAGGAGTACCCCTGCCCTGAGCTGGTGGTTCGCAGGGGCCAGTCGTTCAGCCT
CACGCTGGAGCTGAGCAGAGCCCTGGACTGTGAGGAGATCCTCATCTTCACGATGGAGACAGGACCCCGGGCTTCTGAGGCCCTCCACAC
CAAAGCTGTGTTCCAGACATCGGAGCTGGAGCGGGGTGAGGGCTGGACAGCAGCAAGGGAGGCTCAGATGGAGAAAACTCTGACCGTCAG
TCTCGCCAGCCCTCCCAGTGCTGTCATTGGCCGCTACCTGCTGAGCATCAGGCTTTCCTCTCACCGCAAACACAGCAACCGGAGGCTGGG
CGAGTTTGTTCTCCTTTTCAACCCATGGTGTGCAGAGGACGATGTGTTTCTGGCCTCAGAGGAGGAGAGACAGGAGTACGTGCTCAGCGA
CAGCGGCATCATCTTCCGAGGCGTGGAGAAGCACATACGAGCCCAGGGCTGGAACTACGGGCAGTTTGAGGAGGACATCCTGAACATCTG
CCTCTCCATCCTGGATCGAAGCCCCGGTCACCAAAACAACCCAGCCACCGACGTGTCCTGCCGCCACAACCCCATCTACGTCACCAGGGT
CATCAGTGCCATGGTGAACAGCAACAACGACCGAGGTGTGGTGCAAGGACAGTGGCAGGGCAAGTACGGCGGCGGCACCAGCCCGCTGCA
CTGGCGCGGCAGCGTGGCCATTCTGCAGAAGTGGCTCAAGGGCAGGTACAAGCCAGTCAAGTACGGCCAGTGCTGGGTCTTCGCCGGAGT
CCTGTGCACAGTCCTCAGGTGCTTGGGGATAGCCACACGGGTCGTGTCCAACTTCAACTCAGCCCACGACACAGACCAGAACCTGAGTGT
GGACAAATACGTGGACTCCTTCGGGCGGACCCTGGAGGACCTGACAGAAGACAGCATGTGGAATTTCCATGTCTGGAATGAGAGCTGGTT
TGCCCGGCAGGACCTAGGCCCCTCTTACAATGGCTGGCAGGTTCTGGATGCCACCCCCCAGGAGGAGAGTGAAGGTGTGTTCCGGTGCGG
CCCAGCCTCAGTCACCGCCATCCGCGAGGGTGATGTGCACCTGGCTCACGATGGCCCCTTCGTGTTTGCGGAGGTCAACGCCGACTACAT
CACCTGGCTGTGGCACGAGGATGAGAGCCGGGAGCGTGTATACTCAAACACGAAGAAGATTGGGAGATGCATCAGCACCAAGGCGGTGGG
CAGTGACTCCCGCGTGGACATCACTGACCTCTACAAGTATCCGGAAGGGTCCCGGAAAGAGAGGCAGGTGTACAGCAAGGCGGTGAACAG
GCTGTTCGGCGTGGAAGCCTCTGGAAGGAGAATCTGGATCCGCAGGGCTGGGGGTCGCTGTCTCTGGCGTGACGACCTCCTGGAGCCTGC
CACCAAGCCCAGCATCGCTGGCAAGTTCAAGGTGCTAGAGCCTCCCATGCTGGGCCACGACCTGAGACTGGCCCTGTGCTTGGCCAACCT
CACCTCCCGGGCCCAGCGGGTGAGGGTCAACCTGAGCGGTGCCACCATCCTCTATACCCGCAAGCCAGTGGCAGAGATCCTGCATGAATC
CCACGCCGTGAGGCTGGGGCCGCAAGAAGGGTCTGAGCTGATGCCCAAAGCCCTGTCCACACGCATCATTGGTGGCATCTGGTGGTTCTT
CACGCTCATCATCATCTCTTCCTACACGGCCAACCTGGCTGCCTTTCTGACCGTGGAGCGCATGGAATCACCCATTGACTCTGCTGATGA
CCTGGCCAAGCAAACCAAAATCGAGTATGGGGCTGTCAAGGATGGGGCCACCATGACCTTCTTCAAGAAATCCAAGATCTCCACCTTCGA
GAAGATGTGGGCCTTCATGAGCAGCAAGCCATCGGCGCTGGTGAAGAACAACGAGGAGGGCATCCAGAGGGCCCTGACGGCCGACTACGC
GCTGCTCATGGAGTCCACCACCATCGAGTACGTCACGCAGAGGAACTGCAACCTCACCCAGATCGGGGGCCTCATTGACTCCAAGGGCTA
CGGCATCGGCACGCCCATGGGCTCCCCATACCGGGACAAGATCACCATCGCCATCCTGCAGCTTCAGGAGGAGGACAAGCTGCATATCAT
GAAGGAGAAGTGGTGGCGGGGCAGCGGGTGTCCTGAGGAGGAAAACAAAGAGGCCAGTGCCCTGGGGATCCAGAAGATCGGGGGCATCTT
CATTGTCCTGGCCGCCGGGCTGGTCCTCTCTGTGCTGGTGGCCGTGGGCGAGTTTGTGTACAAGCTCCGCAAAACAGCAGAGAGAGAGCA
GGTAAGCCTTAGAGCTTGGAGCCTGCACAGGATGGGAAATGGAGATTCGCGCTGATTTCACTCCTGTATGTGCCAGGCACACAGTGGTGT
CTCATCTCAGCCTCACAACAGCTCACCCTGCATCCAGTCGGCCAGCAAGCCCTGCCACTCTACCTCTGTCCTGACCTGGCACTTTTTTCC
ATCGCCGTTGCCCCACCCCAGGCCAAGCCCCATCACCTCCTGCCTGGATTATGCCGCAGCCTTCAAACTGGCCCTCCAGCCTCCATGCTT
CCCCAACACCATCCACAATTCACACAGCAACTGGTACCTTGTTTAAAACTTAATTCAAACCATATCATTTTCCTGCATAAAACCCTCCAG

>In-frame_ENST00000202625_ENST00000373093_TCGA-IC-A6RF-11A_TGM6_chr20_2398219_+_GRIK3_chr1_37282878_length(amino acids)=807AA_start in transcript=61_stop in transcript=2484
MAGIRVTKVDWQRSRNGAAHHTQEYPCPELVVRRGQSFSLTLELSRALDCEEILIFTMETGPRASEALHTKAVFQTSELERGEGWTAARE
AQMEKTLTVSLASPPSAVIGRYLLSIRLSSHRKHSNRRLGEFVLLFNPWCAEDDVFLASEEERQEYVLSDSGIIFRGVEKHIRAQGWNYG
QFEEDILNICLSILDRSPGHQNNPATDVSCRHNPIYVTRVISAMVNSNNDRGVVQGQWQGKYGGGTSPLHWRGSVAILQKWLKGRYKPVK
YGQCWVFAGVLCTVLRCLGIATRVVSNFNSAHDTDQNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARQDLGPSYNGWQVLDATPQ
EESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWHEDESRERVYSNTKKIGRCISTKAVGSDSRVDITDLYKYPEGSRKE
RQVYSKAVNRLFGVEASGRRIWIRRAGGRCLWRDDLLEPATKPSIAGKFKVLEPPMLGHDLRLALCLANLTSRAQRVRVNLSGATILYTR
KPVAEILHESHAVRLGPQEGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTF
FKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQ

--------------------------------------------------------------
>In-frame_ENST00000381423_ENST00000373091_TCGA-IC-A6RF-11A_TGM6_chr20_2398219_+_GRIK3_chr1_37282878_length(transcript)=8950nt_BP=1739nt
ACTGTCCTGACGGTGCACACACTGCTGTGTGGAGGAACAGAGGAGTCCAGCTGGCCTTCACATGGCAGGGATCAGAGTCACCAAGGTGGA
CTGGCAGCGGTCGAGGAATGGCGCTGCCCACCACACCCAGGAGTACCCCTGCCCTGAGCTGGTGGTTCGCAGGGGCCAGTCGTTCAGCCT
CACGCTGGAGCTGAGCAGAGCCCTGGACTGTGAGGAGATCCTCATCTTCACGATGGAGACAGGACCCCGGGCTTCTGAGGCCCTCCACAC
CAAAGCTGTGTTCCAGACATCGGAGCTGGAGCGGGGTGAGGGCTGGACAGCAGCAAGGGAGGCTCAGATGGAGAAAACTCTGACCGTCAG
TCTCGCCAGCCCTCCCAGTGCTGTCATTGGCCGCTACCTGCTGAGCATCAGGCTTTCCTCTCACCGCAAACACAGCAACCGGAGGCTGGG
CGAGTTTGTTCTCCTTTTCAACCCATGGTGTGCAGAGGACGATGTGTTTCTGGCCTCAGAGGAGGAGAGACAGGAGTACGTGCTCAGCGA
CAGCGGCATCATCTTCCGAGGCGTGGAGAAGCACATACGAGCCCAGGGCTGGAACTACGGGCAGTTTGAGGAGGACATCCTGAACATCTG
CCTCTCCATCCTGGATCGAAGCCCCGGTCACCAAAACAACCCAGCCACCGACGTGTCCTGCCGCCACAACCCCATCTACGTCACCAGGGT
CATCAGTGCCATGGTGAACAGCAACAACGACCGAGGTGTGGTGCAAGGACAGTGGCAGGGCAAGTACGGCGGCGGCACCAGCCCGCTGCA
CTGGCGCGGCAGCGTGGCCATTCTGCAGAAGTGGCTCAAGGGCAGGTACAAGCCAGTCAAGTACGGCCAGTGCTGGGTCTTCGCCGGAGT
CCTGTGCACAGTCCTCAGGTGCTTGGGGATAGCCACACGGGTCGTGTCCAACTTCAACTCAGCCCACGACACAGACCAGAACCTGAGTGT
GGACAAATACGTGGACTCCTTCGGGCGGACCCTGGAGGACCTGACAGAAGACAGCATGTGGAATTTCCATGTCTGGAATGAGAGCTGGTT
TGCCCGGCAGGACCTAGGCCCCTCTTACAATGGCTGGCAGGTTCTGGATGCCACCCCCCAGGAGGAGAGTGAAGGTGTGTTCCGGTGCGG
CCCAGCCTCAGTCACCGCCATCCGCGAGGGTGATGTGCACCTGGCTCACGATGGCCCCTTCGTGTTTGCGGAGGTCAACGCCGACTACAT
CACCTGGCTGTGGCACGAGGATGAGAGCCGGGAGCGTGTATACTCAAACACGAAGAAGATTGGGAGATGCATCAGCACCAAGGCGGTGGG
CAGTGACTCCCGCGTGGACATCACTGACCTCTACAAGTATCCGGAAGGGTCCCGGAAAGAGAGGCAGGTGTACAGCAAGGCGGTGAACAG
GCTGTTCGGCGTGGAAGCCTCTGGAAGGAGAATCTGGATCCGCAGGGCTGGGGGTCGCTGTCTCTGGCGTGACGACCTCCTGGAGCCTGC
CACCAAGCCCAGCATCGCTGGCAAGTTCAAGGTGCTAGAGCCTCCCATGCTGGGCCACGACCTGAGACTGGCCCTGTGCTTGGCCAACCT
CACCTCCCGGGCCCAGCGGGTGAGGGTCAACCTGAGCGGTGCCACCATCCTCTATACCCGCAAGCCAGTGGCAGAGATCCTGCATGAATC
CCACGCCGTGAGGCTGGGGCCGCAAGAAGGGTCTGAGCTGATGCCCAAAGCCCTGTCCACACGCATCATTGGTGGCATCTGGTGGTTCTT
CACGCTCATCATCATCTCTTCCTACACGGCCAACCTGGCTGCCTTTCTGACCGTGGAGCGCATGGAATCACCCATTGACTCTGCTGATGA
CCTGGCCAAGCAAACCAAAATCGAGTATGGGGCTGTCAAGGATGGGGCCACCATGACCTTCTTCAAGAAATCCAAGATCTCCACCTTCGA
GAAGATGTGGGCCTTCATGAGCAGCAAGCCATCGGCGCTGGTGAAGAACAACGAGGAGGGCATCCAGAGGGCCCTGACGGCCGACTACGC
GCTGCTCATGGAGTCCACCACCATCGAGTACGTCACGCAGAGGAACTGCAACCTCACCCAGATCGGGGGCCTCATTGACTCCAAGGGCTA
CGGCATCGGCACGCCCATGGGCTCCCCATACCGGGACAAGATCACCATCGCCATCCTGCAGCTTCAGGAGGAGGACAAGCTGCATATCAT
GAAGGAGAAGTGGTGGCGGGGCAGCGGGTGTCCTGAGGAGGAAAACAAAGAGGCCAGTGCCCTGGGGATCCAGAAGATCGGGGGCATCTT
CATTGTCCTGGCCGCCGGGCTGGTCCTCTCTGTGCTGGTGGCCGTGGGCGAGTTTGTGTACAAGCTCCGCAAAACAGCAGAGAGAGAGCA
GCGTTCCTTCTGCAGCACCGTGGCCGATGAGATCCGTTTCTCCCTTACCTGCCAGCGTCGAGTCAAGCACAAGCCTCAGCCTCCCATGAT
GGTCAAGACTGACGCCGTCATCAACATGCACACATTCAATGACCGCCGGCTTCCCGGCAAGGACAGCATGGCCTGCAGCACATCCTTAGC
CCCTGTGTTCCCCTAGGCACAGCTGGGGTGGGGACCTCAGGCCTGGGGGCTGGGCAGAGGAAAGCAAAGGAGATTGGAAGGAACGTCCCC
TGTCCCCGCACTGGGCTTGGGGACCAGAGCTGCCACCTGCCTGTTGGGCCAGGAGCCTCCTGCCCTTACCTGCCAGGAAGCCAGCAGGCT
CTCAGGCCAGCTGCTTGGGCTTCATCCTCCTCAGATCTTCTGTGGGTTTCTAAAGCTGCCAGCCGAGATAGCCAAGGCCAAAGGAAGCAC
ATGCCTCTCTCAGGCCAAACTCACCTGCCCCTCAACTCTCCTCCAGAGTCAGAAGTTTCTGCCGCAGCCCTGCAGAGGGCACAGAAAATG
GAAGACAGCTCTTATATTGCCATTTCTTCCACAAGAGCCCAGGCCTCCTACAGCTTGACCGTGAGGCCAGAGACACAAGCCTTCGGCGCC
TTAAGGATGTTCTAGCATGGCTGCCAATGGGAGCTCATGGTGAGGGATACCCATCCCATATGCCTGGGCAGAAGGAAGACTTCATCCCTC
TGGGGCTGTTCACGTGGTCCTAATCTTCTGAACTTGGCGCTGCCCCTGGCAGCCCCTGTTCTGGCAGAGTTGAAGACAGAGCTACACAGG
GGAAAAGAGGAGTTTGGGGTATGGGAGAGAAGAGAATGCACAAACAGAGGCCGCCATTTTGGATTCTTATGGACAATGACCCAGTGGTTC
CTAATCCTCTAGGAGGTCTCTAAGAATATAAGTGGGGGAGTGGCCACAGAAAATTCTTCTCCACTTTCTAGCCAGAGGAGAGAGGACCCC
CTGAATTTCTCACAAAGGATGCCCAAAGATGCAGCCGGTATTTGAAGCCCAGCAGAGGAAAAGCAGATTCCATGGAAGTCCCACCGGCTC
TTGTGCCAATGGATCTCACTTTCCTGGTTAGCAAGCTGTTGTCTAAACCCTGTTCACATTTGGAAACCTGGGCTCTTTGCCATCTTCTCA
TCAACAACTCCCCATTCCTGGCTGGTTGACCTTGGCCTCACTCTGTCTTTTTGAAAGAAGAGTTGGTTGAAGTGAAAGTCAAGTTGTCCC
TCCTCAAAAAAGGAGTTAGTGTCCTACTACACAGACTAACTTTGGGCTAGGTGAGGGAAACCAGAAGAGACCAAAAGAACTTCTGGTCTC
CTGGACTTACCAAACCTAGAGATGCTCCCCAGGAAAAGAAAGTTTCCAGGGACATAATATCATAGCTGGCAGAGGCCCCAAGGGTGGGGA
GGAAGAAGCTGCCTCCTGGAGAATTAACCAAAGACCCCACACAGAGACATGAGGCCATCCTGGCCCCTTGTCTGTTGTCCAGAGCAGCTA
TGGCATTGTGGGGCTTGGGGAAGACAGCAGAGAAGTAGCAGCAGGTTGGGTACCAGCCAGGGGGTGGACCTATGAGTTCCAGCTTGCTGT
GATGAATGCTCTAGAGGTCTGTGACTTTAAGAGTCTTGGAAAAGAATGAGACATGAAGGATTAGGAACAAAGTGTCCTTAAAGAGAACAT
GATGGGCCAGCAGGGTTACCATGGCCAAGGATGGAGGGGCAGGTTTTGAACAGGGGAGGGAGGTTCTGGGGATTCTGGATGAGAACTGGG
GCATACCAGCCACTCCCCTCCCACCTCTGTCCCATGCTGCTTGGGAAGCCCGGTTAGGGAAGAGCTTCATTTGGATCTCAAGGGCTTTCT
CATCTGGGTGAAGGGCAATCTCTAGCAAAGCAGGAGACCACAGTGGGCTCATGTGATAAACACTGTCCCTCCTCCAGACTGTGAGCTGCA
GGACCAAACCAGCAGGTTCCCAGAATCCTAGCAGCTCTGACTGGCTATGTACATTGGACGAGGGAGAGGAGGGCTAGACATACACCAAAG
CCCCATGCATGTAATGTTAGGAAAAGCCATGCTGTCATAAGCTTCAGGGTACAGAGGGCGTGTGCATGTGTGTCTGTGTCTTTGTGTTTG
TATGTGTGAGCTTCGGGGGCTGGGGCACAGGACAGATCTGGACATATAACATAGTCCAGGGCATGCAATAATAGGTGAATCCTTGGGGAT
CTGATGTGTGCATATGCGTGCGTATGTGTATCTGAGTGAATTGGGGACGAGGGAGACAAATATGTGAAGCAGCAAGGCCCCATATATGTA
AAAACAGGAGAAGCCATGTCATAATGGGGCCCTGGTGGGTATGCATATGTAAGCATGCATGCATGCATAGGTGTGTGCATGCTGGTGTGT
GTGTGTGCACATGTACACTGAATGGCATAGGATGGAGATCAGGATCTTACCTGCAGCTAGCCAAATATGCGTAAAAGGAGAAGCCATGTC
ACCAAGGGGTCCATGTCTGAGTGCATGTGAACACATGTGTACAGGCATGTGTGCACAGTGGGGAGCGGGGGGAAGGCCAGGACCAGAGAG
TCGTGTGACATGGGTCAATGCATGCTGTAGACAAGAAGCCACGTGGAGTTGAAGTTTCCGAGTGTGTGGGACACACACATATGTTCCAGG
TCACAGTGGAAGCAAAGACAGACAATCAGGAAGGCCGGGCACCAGGGTCTGTTTGCACTTCTGTCATGGGAGAGATCATTTGTCACAGAG
AGGTTCCAAGGTTGCATGGGCACACTTGCCAGGAGACGGGGGCACAACCCTTCAGGGGCTCATGCTGCTGATGCCTTTGCTGTGGACATC
ATGTCCTGTTTGAAGGGAAAACTCTTTTTTGTAATTCCCAGGTAACAGGATTCTAATGAAGGTATTTGCCAATTTGCTGTCAGCAAACAC
AATCATTAAGCGCCGTCTTACTTTGTCCAGTATAGTTTCAGAGCACGTGCCTCATTCTTGCTCTTGTCTCACACATGTGTTGTGTGTGTG
ATGCTACATGAGCATGTTCTTCAGAGGCTATGCATATATGTGGATTGTGACAGGAGGAAGAAGAAGTGGTGAGAATTTTTATAAAACGAA
CAAAGAATAGTGGATAAATAGAGGCAGAATTCAATTCGAGAAACCCCCCAAAATGTACCGACTGGTCTTTAGACTCCTGTGTGGAAGCAG
GAGGGCATGCTGCCTCATCTCCTCTCCCAGGCAAACCTTGCGTCCTGATGTTCAGGTGTTGTCGGTGTGGCTGATATTTGGCTTCTGGCC
AATATCCTGCATTTGTCCTAGAGACCAGCCTAGTGTTCAAAGTGCAGTGGGGACCACAGCTGCCCAAGCATGAGCTCTGTCTCTCCCGGG
GCACTGAAAATGATGCTACATCTGTGAGGTGGGACGGAGTGGGGAGGTGTTTTCAGTGAGGCAGATCTTGTGTTTTTTTAAGTTTAGGTC
TGTCCTGCCAGTGGGCATGGAGCTGAGCTGGGGCAGGTGCATGCGTGTGTGTGTATGTGTGTGTATGCATGTGTAGTGTGTGTGCACACA
CGCAGGCACTGAGAGGTGATGGGAAGCATGAAAGCTTGCTTGGATGGAGCAGAAGAAGGAACCTGCCTGAGCAGATGCTGGACTGTCCCT
GCGTGGTGCCACATGCCAGCCCTGAACAGAAGAATGTCCCCACTGCATCCCCAAATGCAAGTGCCTCCTCTCCACCTGCTCAAGCTGGCC
AAGTTGAGGGGCAGTGGTAAGAAGACACCAACCCCACCGCCCCTGCCGAGGCCCTGGGACTAAGGACAGTGAGCCCTCCCAATCACTCTC
CCCTTGTCCTGCTGCTGGTTTCTCTGCTCTGGACAGAAGAAAATCCTGAAAGCGTTGTCAATGTTCAAGTGGCCCCATGCTGCAAGAGTC
TCTCGCGAGGGGTGACGCCCCCTTGGCCAGTGTGCTGGACTTTGAGTGTCTGAGGGGTAAGAGGGCCACCCCCTCCTCACAGCCGAGACT
CTATCTAACCTGGAAGCACACTCTGGCTCCACCCCCAACCCCTGCCATGCCCTAGGCCCTGGAAGATGGGAATCCTGGCCCAGGCCAGGG
TAAAGGGCCAAACAGGTTAGAAGTTGCTCCCCTCCACCAGGCGTGCACTCACCAAGAACGATCAAAAGCTCCCTTTCTGCCTACTTTTCC
AGGGGTACTGGGTGTGGGGGGTGGGTCACAGCTCCTGCTTCATCACTCAGCATGAAGTTGGTCCCTCCCTGAGCCACTCCCAGCTACATG
CACAAACATCTGAAAGTAGGCTGGCCTCTCTGGCTCACATCTGGAGTGGTCCTGTGTGGATACCCATCTGCAAAGGGGCTAGAGGTTTGG
ACAAACAGCTGCATGGACTTATCATCTGGGATGGGCCCAGCCTCATGGACAGATACAAGAAATGAGCCCAACTCTGTGGGCAGGTCTCTG
GATTAGACACATCTGAAAGTTGCAGGTCAAGTGGACACATCTGGAAGTGGCCCGGCTGCTGGCTGCCATGGAAGGGCCGTGCCCTCTGTC
CCCATGGCAGTTTAAATCAGGCCTTCCCTTCAGTCCTGGATTTGCCCTGGAGTAAAAATTTCAGAGCTGAGGTCATACGTGAGTCACAAA
ACTTTTAGGTAGAAGGTTAATGTTCTGTACAATATATATATGAATGTAAAATATATATATATACTGTATATATATATATATATGCACAGT
GTATATATGACCTGTAGCCCATGTGTATACAACCCTTTCCTGCACGTCTGCACACGGAGTGTACAGAACCCAGCCAGCACGGGTGAGGAC
CAGATGAGAGATGGGGGCTGCAGCAGCAAAGTCTGGGACGGAGGTCTCAGAGAGCCCCTTGGGGTGGCGAAGGCCCTCCACACATCAGAG
CTCCAGACCCTGAAGAAGAGGGCAGAGCTACATGGTGCTGCCAGGTGAGTCCTGCACCGCCAGGGCCTCCTGTGGGAGGGGCAGGAATGG
CCAACGGACCTCATCTCCATCCGAGCCTGTCTGAGGCAGGACAGCTGGGTGTGTCTGAGAAGCAATGTCATGCTAGTACTCAGCCCCTGT
GCCAATATTACATTCTAGTTCTGGGGCAATTCATCAGGAGCAGAAGGGCTGGGAAAGAGCAGGCCACTCCCCAGGCCTGTTCTCACACCT
GCCTGCAGAATCACAGGTAGGTTTCAGGCTCCATCTAGGATACCCTAGAAGGCGGGGCTATTCTAGGTAGCAAAAGCCTCTGCCTCTGAT
TCTCACCCACATGCAGAAGCAGTCACAACTTGCACACAACACAGCTCACAACTAGGGAAAGCACTTGTTAAAGAGAATGCCCCCAGGGCA
TGGCCAGCATGCCGATACAGTGTTCCCATGCCCCTGTTACTGATCCTGTCCTCCTGCCTTCTAGAACAGTGGACCTCACATCACCTCCCA
GATTGTCTCCATTTTATGGATTGAAACTCTGAGGCCTCCAGACATGAAGAAGCAGCCATAGATTCAGTCAAATGCCAGCCAAGGGTTTGC
CTTGCCTCAGACAACCTCCCCAGCCCCATTTGACCCAGAGACCAGCTGTCAGGGAGCGACCTCAGAGCCAGAGGGGTGAAAGATGAGAGG
CAAGAAGGTAGCTCCTATCCTAGCACAGCCCAGGCTCCATCTGTCTGCCTTTCTCTCCCCTGCGGCATCCTGGCAGGGCAGTTGGCAGAG
TGCCCCCTCCCCAGGAGGCTGCAGATCTCTGTCCCTGGCTCACCCAGATCGGTCTGTTCTCTGCAGTTCCATTCCTTTAGCCTCTTTCGC
AGGTCTGAGCATCTCTGGAGCATGCAGGGGAGGAGATATCTGAGGTGGGCTTCCGTGCAGTCAGCAGCCTGCCCCAGCTTCAGCCTCAGG
CGTCAGGCTGGTCTGCACTGAACTCTGGGTCTGCCTCTGGGGCCCTGACCAAGCACGCCTGACTCCAGCCCCATGAGGAGCATCCTGTCT
TGGTTCCGTAGGGATCATGGGTCCTCTTACCACTGTGCGCCAAGCCCCCAGCCCACCTCTGCCTGGGCCGACTTCCTGGTTGGGCCTCCC
ATGGTAGGGGCCTCAGTTCCCAGGCTCTGGGCTGAGCCCCCAGGGAGCACCATGGGCCTCTGAGACCCTAGACCTGTCCCACCACCCAGA
CCAGAGTGCCTGGACGCCCCCCACTCCCACTCAACATGGTTCCCACACACTGGTCTCTGGGCCATTCAGGGGATGCCCTTTGTGGACATG
CAGAATTTCTATGAATATAGTTTTTTGTAAACATTTTGTAACAATTTGGGTTTCATAGTAACTGTGTTACTTGCCAATCATTCTAGGCTG
ATGTAAATAAATTTCCAAACAAATCTGATTATTTTCCTTTTTAAGACACTGTGATATATCAAAGTGCACAGTTTGCTGTATGAAGTAATA

>In-frame_ENST00000381423_ENST00000373091_TCGA-IC-A6RF-11A_TGM6_chr20_2398219_+_GRIK3_chr1_37282878_length(amino acids)=854AA_start in transcript=61_stop in transcript=2625
MAGIRVTKVDWQRSRNGAAHHTQEYPCPELVVRRGQSFSLTLELSRALDCEEILIFTMETGPRASEALHTKAVFQTSELERGEGWTAARE
AQMEKTLTVSLASPPSAVIGRYLLSIRLSSHRKHSNRRLGEFVLLFNPWCAEDDVFLASEEERQEYVLSDSGIIFRGVEKHIRAQGWNYG
QFEEDILNICLSILDRSPGHQNNPATDVSCRHNPIYVTRVISAMVNSNNDRGVVQGQWQGKYGGGTSPLHWRGSVAILQKWLKGRYKPVK
YGQCWVFAGVLCTVLRCLGIATRVVSNFNSAHDTDQNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARQDLGPSYNGWQVLDATPQ
EESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWHEDESRERVYSNTKKIGRCISTKAVGSDSRVDITDLYKYPEGSRKE
RQVYSKAVNRLFGVEASGRRIWIRRAGGRCLWRDDLLEPATKPSIAGKFKVLEPPMLGHDLRLALCLANLTSRAQRVRVNLSGATILYTR
KPVAEILHESHAVRLGPQEGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTF
FKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQ
LQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRR

--------------------------------------------------------------
>In-frame_ENST00000381423_ENST00000373093_TCGA-IC-A6RF-11A_TGM6_chr20_2398219_+_GRIK3_chr1_37282878_length(transcript)=2800nt_BP=1739nt
ACTGTCCTGACGGTGCACACACTGCTGTGTGGAGGAACAGAGGAGTCCAGCTGGCCTTCACATGGCAGGGATCAGAGTCACCAAGGTGGA
CTGGCAGCGGTCGAGGAATGGCGCTGCCCACCACACCCAGGAGTACCCCTGCCCTGAGCTGGTGGTTCGCAGGGGCCAGTCGTTCAGCCT
CACGCTGGAGCTGAGCAGAGCCCTGGACTGTGAGGAGATCCTCATCTTCACGATGGAGACAGGACCCCGGGCTTCTGAGGCCCTCCACAC
CAAAGCTGTGTTCCAGACATCGGAGCTGGAGCGGGGTGAGGGCTGGACAGCAGCAAGGGAGGCTCAGATGGAGAAAACTCTGACCGTCAG
TCTCGCCAGCCCTCCCAGTGCTGTCATTGGCCGCTACCTGCTGAGCATCAGGCTTTCCTCTCACCGCAAACACAGCAACCGGAGGCTGGG
CGAGTTTGTTCTCCTTTTCAACCCATGGTGTGCAGAGGACGATGTGTTTCTGGCCTCAGAGGAGGAGAGACAGGAGTACGTGCTCAGCGA
CAGCGGCATCATCTTCCGAGGCGTGGAGAAGCACATACGAGCCCAGGGCTGGAACTACGGGCAGTTTGAGGAGGACATCCTGAACATCTG
CCTCTCCATCCTGGATCGAAGCCCCGGTCACCAAAACAACCCAGCCACCGACGTGTCCTGCCGCCACAACCCCATCTACGTCACCAGGGT
CATCAGTGCCATGGTGAACAGCAACAACGACCGAGGTGTGGTGCAAGGACAGTGGCAGGGCAAGTACGGCGGCGGCACCAGCCCGCTGCA
CTGGCGCGGCAGCGTGGCCATTCTGCAGAAGTGGCTCAAGGGCAGGTACAAGCCAGTCAAGTACGGCCAGTGCTGGGTCTTCGCCGGAGT
CCTGTGCACAGTCCTCAGGTGCTTGGGGATAGCCACACGGGTCGTGTCCAACTTCAACTCAGCCCACGACACAGACCAGAACCTGAGTGT
GGACAAATACGTGGACTCCTTCGGGCGGACCCTGGAGGACCTGACAGAAGACAGCATGTGGAATTTCCATGTCTGGAATGAGAGCTGGTT
TGCCCGGCAGGACCTAGGCCCCTCTTACAATGGCTGGCAGGTTCTGGATGCCACCCCCCAGGAGGAGAGTGAAGGTGTGTTCCGGTGCGG
CCCAGCCTCAGTCACCGCCATCCGCGAGGGTGATGTGCACCTGGCTCACGATGGCCCCTTCGTGTTTGCGGAGGTCAACGCCGACTACAT
CACCTGGCTGTGGCACGAGGATGAGAGCCGGGAGCGTGTATACTCAAACACGAAGAAGATTGGGAGATGCATCAGCACCAAGGCGGTGGG
CAGTGACTCCCGCGTGGACATCACTGACCTCTACAAGTATCCGGAAGGGTCCCGGAAAGAGAGGCAGGTGTACAGCAAGGCGGTGAACAG
GCTGTTCGGCGTGGAAGCCTCTGGAAGGAGAATCTGGATCCGCAGGGCTGGGGGTCGCTGTCTCTGGCGTGACGACCTCCTGGAGCCTGC
CACCAAGCCCAGCATCGCTGGCAAGTTCAAGGTGCTAGAGCCTCCCATGCTGGGCCACGACCTGAGACTGGCCCTGTGCTTGGCCAACCT
CACCTCCCGGGCCCAGCGGGTGAGGGTCAACCTGAGCGGTGCCACCATCCTCTATACCCGCAAGCCAGTGGCAGAGATCCTGCATGAATC
CCACGCCGTGAGGCTGGGGCCGCAAGAAGGGTCTGAGCTGATGCCCAAAGCCCTGTCCACACGCATCATTGGTGGCATCTGGTGGTTCTT
CACGCTCATCATCATCTCTTCCTACACGGCCAACCTGGCTGCCTTTCTGACCGTGGAGCGCATGGAATCACCCATTGACTCTGCTGATGA
CCTGGCCAAGCAAACCAAAATCGAGTATGGGGCTGTCAAGGATGGGGCCACCATGACCTTCTTCAAGAAATCCAAGATCTCCACCTTCGA
GAAGATGTGGGCCTTCATGAGCAGCAAGCCATCGGCGCTGGTGAAGAACAACGAGGAGGGCATCCAGAGGGCCCTGACGGCCGACTACGC
GCTGCTCATGGAGTCCACCACCATCGAGTACGTCACGCAGAGGAACTGCAACCTCACCCAGATCGGGGGCCTCATTGACTCCAAGGGCTA
CGGCATCGGCACGCCCATGGGCTCCCCATACCGGGACAAGATCACCATCGCCATCCTGCAGCTTCAGGAGGAGGACAAGCTGCATATCAT
GAAGGAGAAGTGGTGGCGGGGCAGCGGGTGTCCTGAGGAGGAAAACAAAGAGGCCAGTGCCCTGGGGATCCAGAAGATCGGGGGCATCTT
CATTGTCCTGGCCGCCGGGCTGGTCCTCTCTGTGCTGGTGGCCGTGGGCGAGTTTGTGTACAAGCTCCGCAAAACAGCAGAGAGAGAGCA
GGTAAGCCTTAGAGCTTGGAGCCTGCACAGGATGGGAAATGGAGATTCGCGCTGATTTCACTCCTGTATGTGCCAGGCACACAGTGGTGT
CTCATCTCAGCCTCACAACAGCTCACCCTGCATCCAGTCGGCCAGCAAGCCCTGCCACTCTACCTCTGTCCTGACCTGGCACTTTTTTCC
ATCGCCGTTGCCCCACCCCAGGCCAAGCCCCATCACCTCCTGCCTGGATTATGCCGCAGCCTTCAAACTGGCCCTCCAGCCTCCATGCTT
CCCCAACACCATCCACAATTCACACAGCAACTGGTACCTTGTTTAAAACTTAATTCAAACCATATCATTTTCCTGCATAAAACCCTCCAG

>In-frame_ENST00000381423_ENST00000373093_TCGA-IC-A6RF-11A_TGM6_chr20_2398219_+_GRIK3_chr1_37282878_length(amino acids)=807AA_start in transcript=61_stop in transcript=2484
MAGIRVTKVDWQRSRNGAAHHTQEYPCPELVVRRGQSFSLTLELSRALDCEEILIFTMETGPRASEALHTKAVFQTSELERGEGWTAARE
AQMEKTLTVSLASPPSAVIGRYLLSIRLSSHRKHSNRRLGEFVLLFNPWCAEDDVFLASEEERQEYVLSDSGIIFRGVEKHIRAQGWNYG
QFEEDILNICLSILDRSPGHQNNPATDVSCRHNPIYVTRVISAMVNSNNDRGVVQGQWQGKYGGGTSPLHWRGSVAILQKWLKGRYKPVK
YGQCWVFAGVLCTVLRCLGIATRVVSNFNSAHDTDQNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARQDLGPSYNGWQVLDATPQ
EESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWHEDESRERVYSNTKKIGRCISTKAVGSDSRVDITDLYKYPEGSRKE
RQVYSKAVNRLFGVEASGRRIWIRRAGGRCLWRDDLLEPATKPSIAGKFKVLEPPMLGHDLRLALCLANLTSRAQRVRVNLSGATILYTR
KPVAEILHESHAVRLGPQEGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTF
FKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQ

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Fusion Gene PPI Analysis for TGM6-GRIK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TGM6-GRIK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TGM6-GRIK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTGM6C3888031SPINOCEREBELLAR ATAXIA 355GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneTGM6C4707228Inherited acute myeloid leukemia1ORPHANET
TgeneGRIK3C0036341Schizophrenia5PSYGENET
TgeneGRIK3C0001973Alcoholic Intoxication, Chronic2PSYGENET
TgeneGRIK3C0011570Mental Depression1PSYGENET
TgeneGRIK3C0011581Depressive disorder1PSYGENET
TgeneGRIK3C0033975Psychotic Disorders1PSYGENET
TgeneGRIK3C0149925Small cell carcinoma of lung1CTD_human