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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:THADA-EML4 (FusionGDB2 ID:89932)

Fusion Gene Summary for THADA-EML4

check button Fusion gene summary
Fusion gene informationFusion gene name: THADA-EML4
Fusion gene ID: 89932
HgeneTgene
Gene symbol

THADA

EML4

Gene ID

63892

27436

Gene nameTHADA armadillo repeat containingEMAP like 4
SynonymsARMC13|GITAC2orf2|ELP120|EMAP-4|EMAPL4|ROPP120
Cytomap

2p21

2p21

Type of geneprotein-codingprotein-coding
Descriptionthyroid adenoma-associated proteindeath receptor-interacting proteingene inducing thyroid adenomas proteinechinoderm microtubule-associated protein-like 4echinoderm microtubule associated protein like 4restrictedly overexpressed proliferation-associated proteinropp 120
Modification date2020031320200313
UniProtAcc.

Q9HC35

Ensembl transtripts involved in fusion geneENST00000330266, ENST00000405975, 
ENST00000415080, ENST00000405006, 
ENST00000485353, ENST00000402360, 
ENST00000404790, ENST00000403856, 
ENST00000318522, ENST00000402711, 
ENST00000482660, ENST00000401738, 
ENST00000453191, 
Fusion gene scores* DoF score16 X 16 X 12=30729 X 10 X 6=540
# samples 1810
** MAII scorelog2(18/3072*10)=-4.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/540*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: THADA [Title/Abstract] AND EML4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTHADA(43571261)-EML4(42556026), # samples:2
Anticipated loss of major functional domain due to fusion event.THADA-EML4 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across THADA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EML4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2756-01ATHADAchr2

43571261

-EML4chr2

42556026

+
ChimerDB4LUSCTCGA-66-2756-01ATHADAchr2

43571261

-EML4chr2

42556026

+


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Fusion Gene ORF analysis for THADA-EML4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000330266ENST00000318522THADAchr2

43571261

-EML4chr2

42556026

+
intron-3CDSENST00000330266ENST00000402711THADAchr2

43571261

-EML4chr2

42556026

+
intron-intronENST00000330266ENST00000482660THADAchr2

43571261

-EML4chr2

42556026

+
intron-intronENST00000330266ENST00000401738THADAchr2

43571261

-EML4chr2

42556026

+
intron-intronENST00000330266ENST00000453191THADAchr2

43571261

-EML4chr2

42556026

+
In-frameENST00000405975ENST00000318522THADAchr2

43571261

-EML4chr2

42556026

+
In-frameENST00000405975ENST00000402711THADAchr2

43571261

-EML4chr2

42556026

+
5CDS-intronENST00000405975ENST00000482660THADAchr2

43571261

-EML4chr2

42556026

+
5CDS-intronENST00000405975ENST00000401738THADAchr2

43571261

-EML4chr2

42556026

+
5CDS-intronENST00000405975ENST00000453191THADAchr2

43571261

-EML4chr2

42556026

+
In-frameENST00000415080ENST00000318522THADAchr2

43571261

-EML4chr2

42556026

+
In-frameENST00000415080ENST00000402711THADAchr2

43571261

-EML4chr2

42556026

+
5CDS-intronENST00000415080ENST00000482660THADAchr2

43571261

-EML4chr2

42556026

+
5CDS-intronENST00000415080ENST00000401738THADAchr2

43571261

-EML4chr2

42556026

+
5CDS-intronENST00000415080ENST00000453191THADAchr2

43571261

-EML4chr2

42556026

+
Frame-shiftENST00000405006ENST00000318522THADAchr2

43571261

-EML4chr2

42556026

+
Frame-shiftENST00000405006ENST00000402711THADAchr2

43571261

-EML4chr2

42556026

+
5CDS-intronENST00000405006ENST00000482660THADAchr2

43571261

-EML4chr2

42556026

+
5CDS-intronENST00000405006ENST00000401738THADAchr2

43571261

-EML4chr2

42556026

+
5CDS-intronENST00000405006ENST00000453191THADAchr2

43571261

-EML4chr2

42556026

+
intron-3CDSENST00000485353ENST00000318522THADAchr2

43571261

-EML4chr2

42556026

+
intron-3CDSENST00000485353ENST00000402711THADAchr2

43571261

-EML4chr2

42556026

+
intron-intronENST00000485353ENST00000482660THADAchr2

43571261

-EML4chr2

42556026

+
intron-intronENST00000485353ENST00000401738THADAchr2

43571261

-EML4chr2

42556026

+
intron-intronENST00000485353ENST00000453191THADAchr2

43571261

-EML4chr2

42556026

+
intron-3CDSENST00000402360ENST00000318522THADAchr2

43571261

-EML4chr2

42556026

+
intron-3CDSENST00000402360ENST00000402711THADAchr2

43571261

-EML4chr2

42556026

+
intron-intronENST00000402360ENST00000482660THADAchr2

43571261

-EML4chr2

42556026

+
intron-intronENST00000402360ENST00000401738THADAchr2

43571261

-EML4chr2

42556026

+
intron-intronENST00000402360ENST00000453191THADAchr2

43571261

-EML4chr2

42556026

+
intron-3CDSENST00000404790ENST00000318522THADAchr2

43571261

-EML4chr2

42556026

+
intron-3CDSENST00000404790ENST00000402711THADAchr2

43571261

-EML4chr2

42556026

+
intron-intronENST00000404790ENST00000482660THADAchr2

43571261

-EML4chr2

42556026

+
intron-intronENST00000404790ENST00000401738THADAchr2

43571261

-EML4chr2

42556026

+
intron-intronENST00000404790ENST00000453191THADAchr2

43571261

-EML4chr2

42556026

+
intron-3CDSENST00000403856ENST00000318522THADAchr2

43571261

-EML4chr2

42556026

+
intron-3CDSENST00000403856ENST00000402711THADAchr2

43571261

-EML4chr2

42556026

+
intron-intronENST00000403856ENST00000482660THADAchr2

43571261

-EML4chr2

42556026

+
intron-intronENST00000403856ENST00000401738THADAchr2

43571261

-EML4chr2

42556026

+
intron-intronENST00000403856ENST00000453191THADAchr2

43571261

-EML4chr2

42556026

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000405975THADAchr243571261-ENST00000318522EML4chr242556026+7429448314045041454
ENST00000405975THADAchr243571261-ENST00000402711EML4chr242556026+5625448314045041454
ENST00000415080THADAchr243571261-ENST00000318522EML4chr242556026+7342439614044171425
ENST00000415080THADAchr243571261-ENST00000402711EML4chr242556026+5538439614044171425

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000405975ENST00000318522THADAchr243571261-EML4chr242556026+9.93E-050.9999007
ENST00000405975ENST00000402711THADAchr243571261-EML4chr242556026+0.0001478450.9998522
ENST00000415080ENST00000318522THADAchr243571261-EML4chr242556026+0.0002041550.99979585
ENST00000415080ENST00000402711THADAchr243571261-EML4chr242556026+0.0002941710.99970585

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Fusion Genomic Features for THADA-EML4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
THADAchr243571260-EML4chr242556025+9.08E-060.99999094
THADAchr243571260-EML4chr242556025+9.08E-060.99999094

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for THADA-EML4


check button Go to

FGviewer for the breakpoints of chr2:43571261-chr2:42556026

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EML4

Q9HC35

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHADAchr2:43571261chr2:42556026ENST00000405006-3038886_9181447.66666666666671954.0Coiled coilOntology_term=ECO:0000255
HgeneTHADAchr2:43571261chr2:42556026ENST00000405975-3038886_9181447.66666666666671954.0Coiled coilOntology_term=ECO:0000255
HgeneTHADAchr2:43571261chr2:42556026ENST00000405006-30381322_13271447.66666666666671954.0Compositional biasNote=Poly-Leu
HgeneTHADAchr2:43571261chr2:42556026ENST00000405006-30384_71447.66666666666671954.0Compositional biasNote=Poly-Lys
HgeneTHADAchr2:43571261chr2:42556026ENST00000405975-30381322_13271447.66666666666671954.0Compositional biasNote=Poly-Leu
HgeneTHADAchr2:43571261chr2:42556026ENST00000405975-30384_71447.66666666666671954.0Compositional biasNote=Poly-Lys
TgeneEML4chr2:43571261chr2:42556026ENST000003185222023825_864780.3333333333334982.0RepeatNote=WD 13
TgeneEML4chr2:43571261chr2:42556026ENST000004027111922760_818722.3333333333334924.0RepeatNote=WD 12
TgeneEML4chr2:43571261chr2:42556026ENST000004027111922825_864722.3333333333334924.0RepeatNote=WD 13

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHADAchr2:43571261chr2:42556026ENST00000402360-117886_9180938.0Coiled coilOntology_term=ECO:0000255
HgeneTHADAchr2:43571261chr2:42556026ENST00000402360-1171322_13270938.0Compositional biasNote=Poly-Leu
HgeneTHADAchr2:43571261chr2:42556026ENST00000402360-1171529_15320938.0Compositional biasNote=Poly-Ala
HgeneTHADAchr2:43571261chr2:42556026ENST00000402360-1174_70938.0Compositional biasNote=Poly-Lys
HgeneTHADAchr2:43571261chr2:42556026ENST00000405006-30381529_15321447.66666666666671954.0Compositional biasNote=Poly-Ala
HgeneTHADAchr2:43571261chr2:42556026ENST00000405975-30381529_15321447.66666666666671954.0Compositional biasNote=Poly-Ala
TgeneEML4chr2:43571261chr2:42556026ENST0000031852220231_249780.3333333333334982.0RegionMicrotubule-binding
TgeneEML4chr2:43571261chr2:42556026ENST0000040271119221_249722.3333333333334924.0RegionMicrotubule-binding
TgeneEML4chr2:43571261chr2:42556026ENST000003185222023259_297780.3333333333334982.0RepeatNote=WD 1
TgeneEML4chr2:43571261chr2:42556026ENST000003185222023301_348780.3333333333334982.0RepeatNote=WD 2
TgeneEML4chr2:43571261chr2:42556026ENST000003185222023356_396780.3333333333334982.0RepeatNote=WD 3
TgeneEML4chr2:43571261chr2:42556026ENST000003185222023403_438780.3333333333334982.0RepeatNote=WD 4
TgeneEML4chr2:43571261chr2:42556026ENST000003185222023445_484780.3333333333334982.0RepeatNote=WD 5
TgeneEML4chr2:43571261chr2:42556026ENST000003185222023500_538780.3333333333334982.0RepeatNote=WD 6
TgeneEML4chr2:43571261chr2:42556026ENST000003185222023543_579780.3333333333334982.0RepeatNote=WD 7
TgeneEML4chr2:43571261chr2:42556026ENST000003185222023582_621780.3333333333334982.0RepeatNote=WD 8
TgeneEML4chr2:43571261chr2:42556026ENST000003185222023625_662780.3333333333334982.0RepeatNote=WD 9
TgeneEML4chr2:43571261chr2:42556026ENST000003185222023668_704780.3333333333334982.0RepeatNote=WD 10
TgeneEML4chr2:43571261chr2:42556026ENST000003185222023711_750780.3333333333334982.0RepeatNote=WD 11
TgeneEML4chr2:43571261chr2:42556026ENST000003185222023760_818780.3333333333334982.0RepeatNote=WD 12
TgeneEML4chr2:43571261chr2:42556026ENST000004027111922259_297722.3333333333334924.0RepeatNote=WD 1
TgeneEML4chr2:43571261chr2:42556026ENST000004027111922301_348722.3333333333334924.0RepeatNote=WD 2
TgeneEML4chr2:43571261chr2:42556026ENST000004027111922356_396722.3333333333334924.0RepeatNote=WD 3
TgeneEML4chr2:43571261chr2:42556026ENST000004027111922403_438722.3333333333334924.0RepeatNote=WD 4
TgeneEML4chr2:43571261chr2:42556026ENST000004027111922445_484722.3333333333334924.0RepeatNote=WD 5
TgeneEML4chr2:43571261chr2:42556026ENST000004027111922500_538722.3333333333334924.0RepeatNote=WD 6
TgeneEML4chr2:43571261chr2:42556026ENST000004027111922543_579722.3333333333334924.0RepeatNote=WD 7
TgeneEML4chr2:43571261chr2:42556026ENST000004027111922582_621722.3333333333334924.0RepeatNote=WD 8
TgeneEML4chr2:43571261chr2:42556026ENST000004027111922625_662722.3333333333334924.0RepeatNote=WD 9
TgeneEML4chr2:43571261chr2:42556026ENST000004027111922668_704722.3333333333334924.0RepeatNote=WD 10
TgeneEML4chr2:43571261chr2:42556026ENST000004027111922711_750722.3333333333334924.0RepeatNote=WD 11


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Fusion Gene Sequence for THADA-EML4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000405975_ENST00000318522_TCGA-66-2756-01A_THADA_chr2_43571261_-_EML4_chr2_42556026_length(transcript)=7429nt_BP=4483nt
GACCCGGTAGTCGACCGTGGACCGCGCTGCGAGCCTCGGAGACGCCGTAGAAGGAGACCTGCTTCCGGGACTGGACCAGGCGCCTGCGAC
TCTTCTCAGACGCCGACGTGCACGAGTGACTACTATTAATTCTATTTAAAATGGGTGTAAAGAAGAAGAAAGAAATGCAAGTTGCTGCGC
TGACCATTTGCCATCAGGACCTTGAAACTTTGAAATCTTTTGCTGATGTGGAAGGGAAAAATCTAGCTTCTTTGCTGTTACATTGTGTGC
AACTCACGGATGGAGTGTCACAAATCCATTATATTAAACAGATTGTGCCTCTGCTGGAGAAAGCAGATAAAAATGGCATGTGTGATCCCA
CTATTCAAAGTTGTTTGGATATCTTAGCAGGCATTTATCTTTCTTTGAGTCTAAAGAATCCCTTGAAGAAAGTATTGGCAAGCTCACTAA
ATAGCCTGCCTGATTTTTTTCTACCTGAGGCTATGCACCGTTTTACTTCTCGTCTTCAGGAAGAATTGAATACTACTGACTTATACTCTT
ACAGGAAAGTTACTGACAATATTTCTTCCTGTATGGAGAACTTTAACTTGGGTAGAGCAAGTGTTAATAATCTGCTTAAAAATGTGCTTC
ATTTTCTGCAGAAGAGTTTAATTGAAATCCTGGAAGAAAATAGAAAATGTGCTGGAAATCATATTATTCAAACACAGTTGATGAATGACT
TACTGGTAGGCATTAGAGTTTCAATGATGTTAGTACAGAAAGTACAAGATTTCCAGGGAAATCTTTGGAAGACTTCCGATTCTCCCATAT
GGCAAAATATGTGTGGATTGCTGAGTATTTTTACCAAGGTTTTAAGCGATGATGATCTGTTACAGACTGTACAGAGCACATCTGGATTAG
CTATTATTCTTTTTATTAAGACTATGTTTCACCCGTCTGAAAAGATTCCTCATTTGATTAGCAGTGTGCTGCTTCGTTCAGTGGACTGCA
CCAGTGTCCCCGAGTGGTTTATGAGCAGCTGCAGGAGCCTCTGTTGTGGTGACATCTCTCAGTCAGCTGTCTTATTCCTCTGTCAGGGGA
CACTTGCCATGTTGGACTGGCAGAACGGAAGCATGGGTCGGAGTGGGGAGGCCCTGCTCTTGGATACTGCACATGTTTTGTTCACCTTGA
GTTCACAGATTAAAGAGCCAACGCTGGAAATGTTTCTGTCTAGAATCTTAGCATCCTGGACTAATTCAGCCATACAAGTCCTTGAATCAA
GTTCCCCGAGCCTAACGGACAGCCTGAATGGGAATTCAAGTATAGTTGGGAGACTTTTGGAATATGTCTATACCCATTGGGAACATCCAT
TGGATGCTCTGAGACACCAAACCAAAATCATGTTCAAAAACCTTCTCCAAATGCACCGGCTCACTGTGGAAGGTGCAGATTTCGTCCCTG
ATCCTTTCTTTGTGGAATTGACTGAGAGTCTTTTACGATTGGAATGGCATATTAAAGGAAAGTACACGTGCCTTGGTTGTTTGGTAGAGT
GCATAGGAGTTGAACATATTTTGGCTATAGATAAAACTATTCCATCTCAAATCTTAGAGGTGATGGGAGACCAGTCATTGGTACCTTATG
CAAGTGACCTCTTGGAAACCATGTTTAGAAATCATAAGAGTCATTTGAAATCCCAGACTGCTGAGAGTTCTTGGATTGACCAGTGGCATG
AGACTTGGGTTTCTCCTCTCCTTTTTATATTGTGTGAAGGAAACTTGGATCAAAAATCTTACGTGATTGATTATTACTTGCCAAAATTAT
TAAGTTACAGCCCTGAAAGCTTACAGTACATGGTAAAGATTCTTCAGACTTCTATTGATGCTAAAACTGGACAAGAGCAATCTTTCCCAT
CCTTAGGGTCTTGTAATAGCAGGGGGGCTCTGGGAGCTTTGATGGCATGTCTGCGAATAGCTAGAGCTCATGGACATCTTCAGTCTGCAA
CTGATACCTGGGAGAACCTCGTGTCTGATGCAAGAATAAAGCAAGGCTTAATTCATCAGCATTGCCAAGTAAGGATAGATACATTAGGCT
TGCTTTGTGAAAGTAATCGGAGCACAGAAATTGTTTCCATGGAAGAAATGCAGTGGATTCAGTTCTTTATTACATACAATCTTAACAGCC
AGTCTCCAGGAGTGCGGCAACAGATCTGTTCTCTTCTTAAAAAGTTGTTTTGTAGGATACAGGAAAGTTCTCAGGTACTTTATAAATTGG
AGCAGAGTAAATCCAAACGTGAACCAGAGAATGAGTTAACCAAACAGCACCCTTCTGTTTCTTTACAGCAGTATAAGAATTTCATGTCAT
CCATTTGTAACAGTCTTTTTGAAGCATTGTTTCCTGGATCTTCCTACTCGACTAGATTTTCAGCTTTAACCATTTTAGGTTCAATAGCTG
AAGTTTTTCATGTCCCAGAAGGCAGAATTTATACAGTATATCAGCTGAGTCATGATATTGATGTTGGTCGTTTCCAAACACTAATGGAAT
GTTTTACCAGCACTTTTGAAGACGTGAAAATTTTAGCATTTGATCTTCTGATGAAGTTATCAAAAACAGCTGTACATTTTCAGGATTCGG
GGAAACTGCAAGGCTTATTTCAGGCAGCATTGGAGCTCAGCACAAGCACCAAACCATACGACTGTGTGACAGCTTCCTACCTGCTGAACT
TCTTAATCTGGCAGGATGCTCTACCGTCATCCTTGTCTGCCTACTTAACTCAGCAAGTTGCATGTGATAATGGAGATAGGCCTGCTGCTG
TGGTGGAAAGGAACACATTAATGGTTATCAAATGCTTGATGGAAAATCTTGAGGAAGAAGTATCTCAGGCTGAAAATTCTCTGCTTCAGG
CAGCAGCAGCATTTCCAATGTATGGGCGAGTCCACTGTATAACAGGAGCTTTGCAGAAGTTATCTCTAAACAGCCTGCAGTTGGTGAGCG
AGTGGAGACCTGTGGTAGAGAAGCTCCTTTTGATGTCCTACAGGCTTTCCACTGTGGTGTCTCCAGTCATTCAGAGCTCATCCCCTGAAG
GCCTCATCCCAATGGACACTGATTCAGAGTCAGCAAGCCGCTTACAGATGATTCTGAATGAGATTCAGCCTCGAGATACTAATGATTATT
TTAACCAAGCCAAAATATTGAAAGAACATGATAGCTTTGATATGAAGGACTTGAATGCTAGTGTGGTGAATATTGATACTTCTACAGAAA
TCAAAGGTAAAGAAGTAAAAACATGTGATGTAACTGCGCAGATGGTGCTGGTATGTTGTTGGAGAAGTATGAAGGAAGTTGCTTTACTTT
TAGGCATGTTGTGCCAGCTTCTGCCCATGCAGCCTGTGCCAGAATCTTCTGATGGATTATTGACGGTGGAGCAGGTAAAAGAAATAGGAG
ATTACTTTAAACAACACCTTTTGCAGTCCAGGCACAGAGGAGCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAA
ACAGGTGCCCAAATGTGAGTCTGCAAAAGCTGCCAGAACAGTGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTA
AACTCTGTGCTACAAGGCGCAGTGCTGGAATTCCTTTCTACATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGT
TGAAAATAACAATGAAAGAGTTAATCTCTTTGGCTGGGCCTACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCC
TTAGAGCATTGTTCAGAGATACGCGCCTGGGAGAAAATATTATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACAT
CACCGGTCTGGGCAGTGCGAAATTCATCCACACTTCTCTTTAGTGCCTTGATCACAAGAATTTTTGGAGTTAAAAGGGCAAAGGATGAAC
ATTCCAAAACAAATAGAATGACAGGGAGAGAGTTTTTCTCTCGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTGTAG
CCAATACAGTAGACAGTGATATGGGAGAACCAAATCGTCATCCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTTCCC
CGATGGATGGTACTTCTTCTGCTCTCAGCATGGGACCTTTTGTTCCCTTCATTATGAGGTGTGGTCACTCACCTGTCTACCACTCCCGTG
AAATGGCAGCTCGTGCCTTGGTCCCATTTGTTATGATAGATCACATTCCTAATACCATTCGAACTCTGTTGTCCACACTCCCCAGCTGCA
CTGACCAGTGTTTCCGGCAAAACCACATTCATGGGACACTTCTCCAGGTTTTTCATTTGTTGCAAGCCTACTCAGACTCCAAACACGGAA
CGAATTCAGACTTCCAGCACGAGCTGACTGACATCACTGTTTGTACCAAAGCCAAACTCTGGCTGGCCAAGAGGTGTCTGGCCAGAAGGA
TCTGATGGGACAGATATCAATGCACTGGTGCGATCCCACAATAGAAAGGTGATAGCTGTTGCCGATGACTTTTGTAAAGTCCATCTGTTT
CAGTATCCCTGCTCCAAAGCAAAGGCTCCCAGTCACAAGTACAGTGCCCACAGCAGCCATGTCACCAATGTCAGTTTTACTCACAATGAC
AGTCACCTGATATCAACTGGTGGAAAAGACATGAGCATCATTCAGTGGAAACTTGTGGAAAAGTTATCTTTGCCTCAGAATGAGACTGTA
GCGGATACTACTCTAACCAAAGCCCCCGTCTCTTCCACTGAAAGTGTCATCCAATCTAATACTCCCACACCGCCTCCTTCTCAGCCCTTA
AATGAGACAGCTGAAGAGGAAAGTAGAATAAGCAGTTCTCCCACACTTCTGGAGAACAGCCTGGAACAAACTGTGGAGCCAAGTGAAGAC
CACAGCGAGGAGGAGAGTGAAGAGGGCAGCGGAGACCTTGGTGAGCCTCTTTATGAAGAGCCATGCAACGAGATAAGCAAGGAGCAGGCC
AAAGCCACCCTTCTGGAGGACCAGCAAGACCCTTCGCCCTCGTCCTAACACCCTGGCTTCAGTGCAACTCTTTTCCTTCAGCTGCATGTG
ATTTTGTGATAAAGTTCAGGTAACAGGATGGGCAGTGATGGAGAATCACTGTTGATTGAGATTTTGGTTTCCATGTGATTTGTTTTCTTC
AATAGTCTTATTTTCAGTCTCTCAAATACAGCCAACTTAAAGTTTTAGTTTGGTGTTTATTGAAAATTAACCAAACTTAATACTAGGAGA
AGACTGAATCATTAATGATGTCTCACAAATTACTGTGTACCTAAGTGGTGTGATGTAAATACTGGAAACAAAAACAGCAGTTGCATTGAT
TTTGAAAACAAACCCCCTTGTTATCTGAACATGTTTTCTTCAGGAACAACCAGAGGTATCACAAACACTGTTACTCATCTACTGGCTCAG
ACTGTACTACTTTTTTTTTTTTTTTTCCTGAAAAAGAAACCAGAAAAAAATGTACTCTTACTGAGATACCCTCTCACCCCAAATGTGTAA
TGGAAAATTTTTAATTAAGAAAAACTTCAGTTTTGCCAAGTGCAATGGTGTTGCCTTCTTTAAAAAATGCCGTTTTCTTACACTACCAGT
GGATGTCCAGACATGCTCTTAGTCTACTAGAGAGGTGCTGCCTTTTCTAAGTCATAATGAGGAACAGTCCCTTAATTTCTTGTGTGCAAC
TCTGTTTTATCCTAGAACTAAGAGAGCATTGGTTTGTTAAAGAGCTTTCAATGTATATTAAAACCTTCAATACTCAGAAATGATGGATTC
CTCCAAGGAGTCCTTTACTAGCCTAAACATTCTCAAATGTTTGAGATTCAAGTGAATGGAAGGAAAACCACATGCCTTTAAAACTAAACT
GTAATAATTACCTGGCTAATTTCAGCTAAGCCTTCATCATAATTTGTTCCCTCAGTAATAGGAGAAATATAAATACAGTAAGTTTAGATT
ATTGAATTGGTGCTTGAAATTTATTGGTTTTGTTGTAATTTTATACAGATTATATGAGGGATAAGATACTCATCAAATTGCAAATTCTTT
TTTTTACAGAAGTGTGGGTAACAGTCACAGCAGTTTTTTTTACCAACAGCATACTTAACAGACTTGCTGTGTAGCAGTTTTTTTCTGGTG
GAGTTGCTGTAAGTCTTGTAAGTCTAATGTGGCTATCCTACTCTTTTGGGCAATGCATGTATTATGCATTGGAAAGGTATTTTTTTTAAG
TTCTGTTGGCTAGCTATGGTTTTCAGTACATTTCCTACTTTAAGAGTAATTACTGACAAATATGTATTTCCTATATGTTTATACTTTGAT
TATAAAAAAGTATTTTGTTTTGATTTTTTAACTTGCTGCATTGTTTTGATACTTTCTATTTTTTTGGTCAAATCATGTTTAGAAACTTTG
GATGAGTTAAGAAGTCTTAAGTATGCAGGCGTTTACGTGATTGTGCCATTCCAAAGTGCATCAGAACTGTCATTCCCTTCTAATATCTTC
TCAGGAGTAATACAAATCAGGTATTTCATCATCATTTGGTAATATGAAAACTCCAGTGAACTCCCAAGGACATTTACAACATTTATATTC
ACACGCTGTATGGAAGGGTGTGGGTGTGTGTGAAGGGGCGAGTGGAGACACTGTGTGTATCTCTAGATAAGAAGATATGCACCACGTTGA
AAATACTCAGTGTAGATCTCTATGTGTATAGGTATCTGTATATCTTTCCTTTTGTTTACAACTGTTAAAAAACCTCAAAATAGTTCTCTT
CAAAAGAAGAGAGATTCCAAGCAACCCATCTTTCTTCAGTATGTATGTTCTGTACATACTTATCGGAGCGCGCCAGTAAGTATCAGGCAT
ATATATCTGTCTGTTAGCAATGATTATTACATCATCAGATCAGCATGTGCTATACTCCCTGCAAGAAATATACTGACATGAACAGGCAGT
TCTTGGAGAAGAAAGAGCATTTCTTTAAGTACCTGGGGAATACAGCTCTCAGTGATCAGCAGGGAGTTTATTTGAGGACATCAGTCACCT
TTGGGGTTGCCATGTACAATGAGATTTATAATCATGATACTCTTCGGTGGTAGTTTCAAAAGACACTACTAATACGCAGGAAGCGTTCCA
GCTATTTAATGCTGGCAACTACTGTTTAATGGTCAGTTAAATCTGTGATAATGGTTGGAAGTGGGTGGGGTTATGAAATTGTAGATGTTT
TTAGAAAAACTTGTGAATGAAAATGAATCCAAGTGTTTCATGTGAAGATGTTGAGCCATTGCTATCATGCATTCCTGTCTCATGGCAGAA

>In-frame_ENST00000405975_ENST00000318522_TCGA-66-2756-01A_THADA_chr2_43571261_-_EML4_chr2_42556026_length(amino acids)=1454AA_start in transcript=140_stop in transcript=4504
MGVKKKKEMQVAALTICHQDLETLKSFADVEGKNLASLLLHCVQLTDGVSQIHYIKQIVPLLEKADKNGMCDPTIQSCLDILAGIYLSLS
LKNPLKKVLASSLNSLPDFFLPEAMHRFTSRLQEELNTTDLYSYRKVTDNISSCMENFNLGRASVNNLLKNVLHFLQKSLIEILEENRKC
AGNHIIQTQLMNDLLVGIRVSMMLVQKVQDFQGNLWKTSDSPIWQNMCGLLSIFTKVLSDDDLLQTVQSTSGLAIILFIKTMFHPSEKIP
HLISSVLLRSVDCTSVPEWFMSSCRSLCCGDISQSAVLFLCQGTLAMLDWQNGSMGRSGEALLLDTAHVLFTLSSQIKEPTLEMFLSRIL
ASWTNSAIQVLESSSPSLTDSLNGNSSIVGRLLEYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVEGADFVPDPFFVELTESLLRLEWH
IKGKYTCLGCLVECIGVEHILAIDKTIPSQILEVMGDQSLVPYASDLLETMFRNHKSHLKSQTAESSWIDQWHETWVSPLLFILCEGNLD
QKSYVIDYYLPKLLSYSPESLQYMVKILQTSIDAKTGQEQSFPSLGSCNSRGALGALMACLRIARAHGHLQSATDTWENLVSDARIKQGL
IHQHCQVRIDTLGLLCESNRSTEIVSMEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKLEQSKSKREPENELTKQH
PSVSLQQYKNFMSSICNSLFEALFPGSSYSTRFSALTILGSIAEVFHVPEGRIYTVYQLSHDIDVGRFQTLMECFTSTFEDVKILAFDLL
MKLSKTAVHFQDSGKLQGLFQAALELSTSTKPYDCVTASYLLNFLIWQDALPSSLSAYLTQQVACDNGDRPAAVVERNTLMVIKCLMENL
EEEVSQAENSLLQAAAAFPMYGRVHCITGALQKLSLNSLQLVSEWRPVVEKLLLMSYRLSTVVSPVIQSSSPEGLIPMDTDSESASRLQM
ILNEIQPRDTNDYFNQAKILKEHDSFDMKDLNASVVNIDTSTEIKGKEVKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPMQPVPESS
DGLLTVEQVKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQA
LLASEPKKGRMDLLKITMKELISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWAVRNSSTLLFSAL
ITRIFGVKRAKDEHSKTNRMTGREFFSRFPELYPFLLKQLETVANTVDSDMGEPNRHPSMFLLLLVLERLYASPMDGTSSALSMGPFVPF
IMRCGHSPVYHSREMAARALVPFVMIDHIPNTIRTLLSTLPSCTDQCFRQNHIHGTLLQVFHLLQAYSDSKHGTNSDFQHELTDITVCTK

--------------------------------------------------------------
>In-frame_ENST00000405975_ENST00000402711_TCGA-66-2756-01A_THADA_chr2_43571261_-_EML4_chr2_42556026_length(transcript)=5625nt_BP=4483nt
GACCCGGTAGTCGACCGTGGACCGCGCTGCGAGCCTCGGAGACGCCGTAGAAGGAGACCTGCTTCCGGGACTGGACCAGGCGCCTGCGAC
TCTTCTCAGACGCCGACGTGCACGAGTGACTACTATTAATTCTATTTAAAATGGGTGTAAAGAAGAAGAAAGAAATGCAAGTTGCTGCGC
TGACCATTTGCCATCAGGACCTTGAAACTTTGAAATCTTTTGCTGATGTGGAAGGGAAAAATCTAGCTTCTTTGCTGTTACATTGTGTGC
AACTCACGGATGGAGTGTCACAAATCCATTATATTAAACAGATTGTGCCTCTGCTGGAGAAAGCAGATAAAAATGGCATGTGTGATCCCA
CTATTCAAAGTTGTTTGGATATCTTAGCAGGCATTTATCTTTCTTTGAGTCTAAAGAATCCCTTGAAGAAAGTATTGGCAAGCTCACTAA
ATAGCCTGCCTGATTTTTTTCTACCTGAGGCTATGCACCGTTTTACTTCTCGTCTTCAGGAAGAATTGAATACTACTGACTTATACTCTT
ACAGGAAAGTTACTGACAATATTTCTTCCTGTATGGAGAACTTTAACTTGGGTAGAGCAAGTGTTAATAATCTGCTTAAAAATGTGCTTC
ATTTTCTGCAGAAGAGTTTAATTGAAATCCTGGAAGAAAATAGAAAATGTGCTGGAAATCATATTATTCAAACACAGTTGATGAATGACT
TACTGGTAGGCATTAGAGTTTCAATGATGTTAGTACAGAAAGTACAAGATTTCCAGGGAAATCTTTGGAAGACTTCCGATTCTCCCATAT
GGCAAAATATGTGTGGATTGCTGAGTATTTTTACCAAGGTTTTAAGCGATGATGATCTGTTACAGACTGTACAGAGCACATCTGGATTAG
CTATTATTCTTTTTATTAAGACTATGTTTCACCCGTCTGAAAAGATTCCTCATTTGATTAGCAGTGTGCTGCTTCGTTCAGTGGACTGCA
CCAGTGTCCCCGAGTGGTTTATGAGCAGCTGCAGGAGCCTCTGTTGTGGTGACATCTCTCAGTCAGCTGTCTTATTCCTCTGTCAGGGGA
CACTTGCCATGTTGGACTGGCAGAACGGAAGCATGGGTCGGAGTGGGGAGGCCCTGCTCTTGGATACTGCACATGTTTTGTTCACCTTGA
GTTCACAGATTAAAGAGCCAACGCTGGAAATGTTTCTGTCTAGAATCTTAGCATCCTGGACTAATTCAGCCATACAAGTCCTTGAATCAA
GTTCCCCGAGCCTAACGGACAGCCTGAATGGGAATTCAAGTATAGTTGGGAGACTTTTGGAATATGTCTATACCCATTGGGAACATCCAT
TGGATGCTCTGAGACACCAAACCAAAATCATGTTCAAAAACCTTCTCCAAATGCACCGGCTCACTGTGGAAGGTGCAGATTTCGTCCCTG
ATCCTTTCTTTGTGGAATTGACTGAGAGTCTTTTACGATTGGAATGGCATATTAAAGGAAAGTACACGTGCCTTGGTTGTTTGGTAGAGT
GCATAGGAGTTGAACATATTTTGGCTATAGATAAAACTATTCCATCTCAAATCTTAGAGGTGATGGGAGACCAGTCATTGGTACCTTATG
CAAGTGACCTCTTGGAAACCATGTTTAGAAATCATAAGAGTCATTTGAAATCCCAGACTGCTGAGAGTTCTTGGATTGACCAGTGGCATG
AGACTTGGGTTTCTCCTCTCCTTTTTATATTGTGTGAAGGAAACTTGGATCAAAAATCTTACGTGATTGATTATTACTTGCCAAAATTAT
TAAGTTACAGCCCTGAAAGCTTACAGTACATGGTAAAGATTCTTCAGACTTCTATTGATGCTAAAACTGGACAAGAGCAATCTTTCCCAT
CCTTAGGGTCTTGTAATAGCAGGGGGGCTCTGGGAGCTTTGATGGCATGTCTGCGAATAGCTAGAGCTCATGGACATCTTCAGTCTGCAA
CTGATACCTGGGAGAACCTCGTGTCTGATGCAAGAATAAAGCAAGGCTTAATTCATCAGCATTGCCAAGTAAGGATAGATACATTAGGCT
TGCTTTGTGAAAGTAATCGGAGCACAGAAATTGTTTCCATGGAAGAAATGCAGTGGATTCAGTTCTTTATTACATACAATCTTAACAGCC
AGTCTCCAGGAGTGCGGCAACAGATCTGTTCTCTTCTTAAAAAGTTGTTTTGTAGGATACAGGAAAGTTCTCAGGTACTTTATAAATTGG
AGCAGAGTAAATCCAAACGTGAACCAGAGAATGAGTTAACCAAACAGCACCCTTCTGTTTCTTTACAGCAGTATAAGAATTTCATGTCAT
CCATTTGTAACAGTCTTTTTGAAGCATTGTTTCCTGGATCTTCCTACTCGACTAGATTTTCAGCTTTAACCATTTTAGGTTCAATAGCTG
AAGTTTTTCATGTCCCAGAAGGCAGAATTTATACAGTATATCAGCTGAGTCATGATATTGATGTTGGTCGTTTCCAAACACTAATGGAAT
GTTTTACCAGCACTTTTGAAGACGTGAAAATTTTAGCATTTGATCTTCTGATGAAGTTATCAAAAACAGCTGTACATTTTCAGGATTCGG
GGAAACTGCAAGGCTTATTTCAGGCAGCATTGGAGCTCAGCACAAGCACCAAACCATACGACTGTGTGACAGCTTCCTACCTGCTGAACT
TCTTAATCTGGCAGGATGCTCTACCGTCATCCTTGTCTGCCTACTTAACTCAGCAAGTTGCATGTGATAATGGAGATAGGCCTGCTGCTG
TGGTGGAAAGGAACACATTAATGGTTATCAAATGCTTGATGGAAAATCTTGAGGAAGAAGTATCTCAGGCTGAAAATTCTCTGCTTCAGG
CAGCAGCAGCATTTCCAATGTATGGGCGAGTCCACTGTATAACAGGAGCTTTGCAGAAGTTATCTCTAAACAGCCTGCAGTTGGTGAGCG
AGTGGAGACCTGTGGTAGAGAAGCTCCTTTTGATGTCCTACAGGCTTTCCACTGTGGTGTCTCCAGTCATTCAGAGCTCATCCCCTGAAG
GCCTCATCCCAATGGACACTGATTCAGAGTCAGCAAGCCGCTTACAGATGATTCTGAATGAGATTCAGCCTCGAGATACTAATGATTATT
TTAACCAAGCCAAAATATTGAAAGAACATGATAGCTTTGATATGAAGGACTTGAATGCTAGTGTGGTGAATATTGATACTTCTACAGAAA
TCAAAGGTAAAGAAGTAAAAACATGTGATGTAACTGCGCAGATGGTGCTGGTATGTTGTTGGAGAAGTATGAAGGAAGTTGCTTTACTTT
TAGGCATGTTGTGCCAGCTTCTGCCCATGCAGCCTGTGCCAGAATCTTCTGATGGATTATTGACGGTGGAGCAGGTAAAAGAAATAGGAG
ATTACTTTAAACAACACCTTTTGCAGTCCAGGCACAGAGGAGCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAA
ACAGGTGCCCAAATGTGAGTCTGCAAAAGCTGCCAGAACAGTGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTA
AACTCTGTGCTACAAGGCGCAGTGCTGGAATTCCTTTCTACATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGT
TGAAAATAACAATGAAAGAGTTAATCTCTTTGGCTGGGCCTACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCC
TTAGAGCATTGTTCAGAGATACGCGCCTGGGAGAAAATATTATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACAT
CACCGGTCTGGGCAGTGCGAAATTCATCCACACTTCTCTTTAGTGCCTTGATCACAAGAATTTTTGGAGTTAAAAGGGCAAAGGATGAAC
ATTCCAAAACAAATAGAATGACAGGGAGAGAGTTTTTCTCTCGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTGTAG
CCAATACAGTAGACAGTGATATGGGAGAACCAAATCGTCATCCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTTCCC
CGATGGATGGTACTTCTTCTGCTCTCAGCATGGGACCTTTTGTTCCCTTCATTATGAGGTGTGGTCACTCACCTGTCTACCACTCCCGTG
AAATGGCAGCTCGTGCCTTGGTCCCATTTGTTATGATAGATCACATTCCTAATACCATTCGAACTCTGTTGTCCACACTCCCCAGCTGCA
CTGACCAGTGTTTCCGGCAAAACCACATTCATGGGACACTTCTCCAGGTTTTTCATTTGTTGCAAGCCTACTCAGACTCCAAACACGGAA
CGAATTCAGACTTCCAGCACGAGCTGACTGACATCACTGTTTGTACCAAAGCCAAACTCTGGCTGGCCAAGAGGTGTCTGGCCAGAAGGA
TCTGATGGGACAGATATCAATGCACTGGTGCGATCCCACAATAGAAAGGTGATAGCTGTTGCCGATGACTTTTGTAAAGTCCATCTGTTT
CAGTATCCCTGCTCCAAAGCAAAGGCTCCCAGTCACAAGTACAGTGCCCACAGCAGCCATGTCACCAATGTCAGTTTTACTCACAATGAC
AGTCACCTGATATCAACTGGTGGAAAAGACATGAGCATCATTCAGTGGAAACTTGTGGAAAAGTTATCTTTGCCTCAGAATGAGACTGTA
GCGGATACTACTCTAACCAAAGCCCCCGTCTCTTCCACTGAAAGTGTCATCCAATCTAATACTCCCACACCGCCTCCTTCTCAGCCCTTA
AATGAGACAGCTGAAGAGGAAAGTAGAATAAGCAGTTCTCCCACACTTCTGGAGAACAGCCTGGAACAAACTGTGGAGCCAAGTGAAGAC
CACAGCGAGGAGGAGAGTGAAGAGGGCAGCGGAGACCTTGGTGAGCCTCTTTATGAAGAGCCATGCAACGAGATAAGCAAGGAGCAGGCC
AAAGCCACCCTTCTGGAGGACCAGCAAGACCCTTCGCCCTCGTCCTAACACCCTGGCTTCAGTGCAACTCTTTTCCTTCAGCTGCATGTG
ATTTTGTGATAAAGTTCAGGTAACAGGATGGGCAGTGATGGAGAATCACTGTTGATTGAGATTTTGGTTTCCATGTGATTTGTTTTCTTC
AATAGTCTTATTTTCAGTCTCTCAAATACAGCCAACTTAAAGTTTTAGTTTGGTGTTTATTGAAAATTAACCAAACTTAATACTAGGAGA
AGACTGAATCATTAATGATGTCTCACAAATTACTGTGTACCTAAGTGGTGTGATGTAAATACTGGAAACAAAAACAGCAGTTGCATTGAT
TTTGAAAACAAACCCCCTTGTTATCTGAACATGTTTTCTTCAGGAACAACCAGAGGTATCACAAACACTGTTACTCATCTACTGGCTCAG
ACTGTACTACTTTTTTTTTTTTTTTTCCTGAAAAAGAAACCAGAAAAAAATGTACTCTTACTGAGATACCCTCTCACCCCAAATGTGTAA

>In-frame_ENST00000405975_ENST00000402711_TCGA-66-2756-01A_THADA_chr2_43571261_-_EML4_chr2_42556026_length(amino acids)=1454AA_start in transcript=140_stop in transcript=4504
MGVKKKKEMQVAALTICHQDLETLKSFADVEGKNLASLLLHCVQLTDGVSQIHYIKQIVPLLEKADKNGMCDPTIQSCLDILAGIYLSLS
LKNPLKKVLASSLNSLPDFFLPEAMHRFTSRLQEELNTTDLYSYRKVTDNISSCMENFNLGRASVNNLLKNVLHFLQKSLIEILEENRKC
AGNHIIQTQLMNDLLVGIRVSMMLVQKVQDFQGNLWKTSDSPIWQNMCGLLSIFTKVLSDDDLLQTVQSTSGLAIILFIKTMFHPSEKIP
HLISSVLLRSVDCTSVPEWFMSSCRSLCCGDISQSAVLFLCQGTLAMLDWQNGSMGRSGEALLLDTAHVLFTLSSQIKEPTLEMFLSRIL
ASWTNSAIQVLESSSPSLTDSLNGNSSIVGRLLEYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVEGADFVPDPFFVELTESLLRLEWH
IKGKYTCLGCLVECIGVEHILAIDKTIPSQILEVMGDQSLVPYASDLLETMFRNHKSHLKSQTAESSWIDQWHETWVSPLLFILCEGNLD
QKSYVIDYYLPKLLSYSPESLQYMVKILQTSIDAKTGQEQSFPSLGSCNSRGALGALMACLRIARAHGHLQSATDTWENLVSDARIKQGL
IHQHCQVRIDTLGLLCESNRSTEIVSMEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKLEQSKSKREPENELTKQH
PSVSLQQYKNFMSSICNSLFEALFPGSSYSTRFSALTILGSIAEVFHVPEGRIYTVYQLSHDIDVGRFQTLMECFTSTFEDVKILAFDLL
MKLSKTAVHFQDSGKLQGLFQAALELSTSTKPYDCVTASYLLNFLIWQDALPSSLSAYLTQQVACDNGDRPAAVVERNTLMVIKCLMENL
EEEVSQAENSLLQAAAAFPMYGRVHCITGALQKLSLNSLQLVSEWRPVVEKLLLMSYRLSTVVSPVIQSSSPEGLIPMDTDSESASRLQM
ILNEIQPRDTNDYFNQAKILKEHDSFDMKDLNASVVNIDTSTEIKGKEVKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPMQPVPESS
DGLLTVEQVKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQA
LLASEPKKGRMDLLKITMKELISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWAVRNSSTLLFSAL
ITRIFGVKRAKDEHSKTNRMTGREFFSRFPELYPFLLKQLETVANTVDSDMGEPNRHPSMFLLLLVLERLYASPMDGTSSALSMGPFVPF
IMRCGHSPVYHSREMAARALVPFVMIDHIPNTIRTLLSTLPSCTDQCFRQNHIHGTLLQVFHLLQAYSDSKHGTNSDFQHELTDITVCTK

--------------------------------------------------------------
>In-frame_ENST00000415080_ENST00000318522_TCGA-66-2756-01A_THADA_chr2_43571261_-_EML4_chr2_42556026_length(transcript)=7342nt_BP=4396nt
GACCCGGTAGTCGACCGTGGACCGCGCTGCGAGCCTCGGAGACGCCGTAGAAGGAGACCTGCTTCCGGGACTGGACCAGGCGCCTGCGAC
TCTTCTCAGACGCCGACGTGCACGAGTGACTACTATTAATTCTATTTAAAATGGGTGTAAAGAAGAAGAAAGAAATGCAAGTTGCTGCGC
TGACCATTTGCCATCAGGACCTTGAAACTTTGAAATCTTTTGCTGATGTGGAAGGGAAAAATCTAGCTTCTTTGCTGTTACATTGTGTGC
AACTCACGGATGGAGTGTCACAAATCCATTATATTAAACAGATTGTGCCTCTGCTGGAGAAAGCAGATAAAAATGGCATGTGTGATCCCA
CTATTCAAAGTTGTTTGGATATCTTAGCAGGCATTTATCTTTCTTTGAGTCTAAAGAATCCCTTGAAGAAAGTATTGGCAAGCTCACTAA
ATAGCCTGCCTGATTTTTTTCTACCTGAGGCTATGCACCGTTTTACTTCTCGTCTTCAGGAAGAATTGAATACTACTGACTTATACTCTT
ACAGGAAAGTTACTGACAATATTTCTTCCTGTATGGAGAACTTTAACTTGGGTAGAGCAAGTGTTAATAATCTGCTTAAAAATGTGCTTC
ATTTTCTGCAGAAGAGTTTAATTGAAATCCTGGAAGAAAATAGAAAATGTGCTGGAAATCATATTATTCAAACACAGTTGATGAATGACT
TACTGGTAGGCATTAGAGTTTCAATGATGTTAGTACAGAAAGTACAAGATTTCCAGGGAAATCTTTGGAAGACTTCCGATTCTCCCATAT
GGCAAAATATGTGTGGATTGCTGAGTATTTTTACCAAGGTTTTAAGCGATGATGATCTGTTACAGACTGTACAGAGCACATCTGGATTAG
CTATTATTCTTTTTATTAAGACTATGTTTCACCCGTCTGAAAAGATTCCTCATTTGATTAGCAGTGTGCTGCTTCGTTCAGTGGACTGCA
CCAGTGTCCCCGAGTGGTTTATGAGCAGCTGCAGGAGCCTCTGTTGTGGTGACATCTCTCAGTCAGCTGTCTTATTCCTCTGTCAGGGGA
CACTTGCCATGTTGGACTGGCAGAACGGAAGCATGGGTCGGAGTGGGGAGGCCCTGCTCTTGGATACTGCACATGTTTTGTTCACCTTGA
GTTCACAGATTAAAGAGCCAACGCTGGAAATGTTTCTGTCTAGAATCTTAGCATCCTGGACTAATTCAGCCATACAAGTCCTTGAATCAA
GTTCCCCGAGCCTAACGGACAGCCTGAATGGGAATTCAAGTATAGTTGGGAGACTTTTGGAATATGTCTATACCCATTGGGAACATCCAT
TGGATGCTCTGAGACACCAAACCAAAATCATGTTCAAAAACCTTCTCCAAATGCACCGGCTCACTGTGGAAGGTGCAGATTTCGTCCCTG
ATCCTTTCTTTGTGGAATTGACTGAGAGTCTTTTACGATTGGAATGGCATATTAAAGGAAAGTACACGTGCCTTGGTTGTTTGGTAGAGT
GCATAGGAGTTGAACATATTTTGGCTATAGATAAAACTATTCCATCTCAAATCTTAGAGGTGATGGGAGACCAGTCATTGGTACCTTATG
CAAGTGACCTCTTGGAAACCATGTTTAGAAATCATAAGAGTCATTTGAAATCCCAGACTGCTGAGAGTTCTTGGATTGACCAGTGGCATG
AGACTTGGGTTTCTCCTCTCCTTTTTATATTGTGTGAAGGAAACTTGGATCAAAAATCTTACGTGATTGATTATTACTTGCCAAAATTAT
TAAGTTACAGCCCTGAAAGCTTACAGTACATGGTAAAGATTCTTCAGACTTCTATTGATGCTAAAACTGGACAAGAGCAATCTTTCCCAT
CCTTAGGGTCTTGTAATAGCAGGGGGGCTCTGGGAGCTTTGATGGCATGTCTGCGAATAGCTAGAGCTCATGGACATCTTCAGTCTGCAA
CTGATACCTGGGAGAACCTCGTGTCTGATGCAAGAATAAAGCAAGGCTTAATTCATCAGCATTGCCAAGTAAGGATAGATACATTAGGCT
TGCTTTGTGAAAGTAATCGGAGCACAGAAATTGTTTCCATGGAAGAAATGCAGTGGATTCAGTTCTTTATTACATACAATCTTAACAGCC
AGTCTCCAGGAGTGCGGCAACAGATCTGTTCTCTTCTTAAAAAGTTGTTTTGTAGGATACAGGAAAGTTCTCAGGTACTTTATAAATTGG
AGCAGAGTAAATCCAAACGTGAACCAGAGAATGAGTTAACCAAACAGCACCCTTCTGTTTCTTTACAGCAGTATAAGAATTTCATGTCAT
CCATTTGTAACAGTCTTTTTGAAGCATTGTTTCCTGGATCTTCCTACTCGACTAGATTTTCAGCTTTAACCATTTTAGGTTCAATAGCTG
AAGTTTTTCATGTCCCAGAAGGCAGAATTTATACAGTATATCAGCTGAGTCATGATATTGATGTTGGTCGTTTCCAAACACTAATGGAAT
GTTTTACCAGCACTTTTGAAGACGTGAAAATTTTAGCATTTGATCTTCTGATGAAGTTATCAAAAACAGCTGTACATTTTCAGGATTCGG
GGAAACTGCAAGGCTTATTTCAGGCAGCATTGGAGCTCAGCACAAGCACCAAACCATACGACTGTGTGACAGCTTCCTACCTGCTGAACT
TCTTAATCTGGCAGGATGCTCTACCGTCATCCTTGTCTGCCTACTTAACTCAGCAAGTTGCATGTGATAATGGAGATAGGCCTGCTGCTG
TGGTGGAAAGGAACACATTAATGGTTATCAAATGCTTGATGGAAAATCTTGAGGAAGAAGTATCTCAGGCTGAAAATTCTCTGCTTCAGG
CAGCAGCAGCATTTCCAATGTATGGGCGAGTCCACTGTATAACAGGAGCTTTGCAGAAGTTATCTCTAAACAGCCTGCAGTTGGTGAGCG
AGTGGAGACCTGTGGTAGAGAAGCTCCTTTTGATGTCCTACAGGCTTTCCACTGTGGTGTCTCCAGTCATTCAGAGCTCATCCCCTGAAG
GCCTCATCCCAATGGACACTGATTCAGAGTCAGCAAGCCGCTTACAGATGATTCTGAATGAGATTCAGCCTCGAGATACTAATGATTATT
TTAACCAAGCCAAAATATTGAAAGAACATGATAGCTTTGATATGAAGGACTTGAATGCTAGTGTGGTGAATATTGATACTTCTACAGAAA
TCAAAGGTAAAGAAGTAAAAACATGTGATGTAACTGCGCAGATGGTGCTGGTATGTTGTTGGAGAAGTATGAAGGAAGTTGCTTTACTTT
TAGGCATGTTGTGCCAGCTTCTGCCCATGCAGCCTGTGCCAGAATCTTCTGATGGATTATTGACGGTGGAGCAGGTAAAAGAAATAGGAG
ATTACTTTAAACAACACCTTTTGCAGTCCAGGCACAGAGGAGCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAA
ACAGGTGCCCAAATGTGAGTCTGCAAAAGCTGCCAGAACAGTGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTA
AACTCTGTGCTACAAGGCGCAGTGCTGGAATTCCTTTCTACATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGT
TGAAAATAACAATGAAAGAGTTAATCTCTTTGGCTGGGCCTACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCC
TTAGAGCATTGTTCAGAGATACGCGCCTGGGAGAAAATATTATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACAT
CACCGGTCTGGGCATCTCAAATGACAGGGAGAGAGTTTTTCTCTCGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTG
TAGCCAATACAGTAGACAGTGATATGGGAGAACCAAATCGTCATCCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTT
CCCCGATGGATGGTACTTCTTCTGCTCTCAGCATGGGACCTTTTGTTCCCTTCATTATGAGGTGTGGTCACTCACCTGTCTACCACTCCC
GTGAAATGGCAGCTCGTGCCTTGGTCCCATTTGTTATGATAGATCACATTCCTAATACCATTCGAACTCTGTTGTCCACACTCCCCAGCT
GCACTGACCAGTGTTTCCGGCAAAACCACATTCATGGGACACTTCTCCAGGTTTTTCATTTGTTGCAAGCCTACTCAGACTCCAAACACG
GAACGAATTCAGACTTCCAGCACGAGCTGACTGACATCACTGTTTGTACCAAAGCCAAACTCTGGCTGGCCAAGAGGTGTCTGGCCAGAA
GGATCTGATGGGACAGATATCAATGCACTGGTGCGATCCCACAATAGAAAGGTGATAGCTGTTGCCGATGACTTTTGTAAAGTCCATCTG
TTTCAGTATCCCTGCTCCAAAGCAAAGGCTCCCAGTCACAAGTACAGTGCCCACAGCAGCCATGTCACCAATGTCAGTTTTACTCACAAT
GACAGTCACCTGATATCAACTGGTGGAAAAGACATGAGCATCATTCAGTGGAAACTTGTGGAAAAGTTATCTTTGCCTCAGAATGAGACT
GTAGCGGATACTACTCTAACCAAAGCCCCCGTCTCTTCCACTGAAAGTGTCATCCAATCTAATACTCCCACACCGCCTCCTTCTCAGCCC
TTAAATGAGACAGCTGAAGAGGAAAGTAGAATAAGCAGTTCTCCCACACTTCTGGAGAACAGCCTGGAACAAACTGTGGAGCCAAGTGAA
GACCACAGCGAGGAGGAGAGTGAAGAGGGCAGCGGAGACCTTGGTGAGCCTCTTTATGAAGAGCCATGCAACGAGATAAGCAAGGAGCAG
GCCAAAGCCACCCTTCTGGAGGACCAGCAAGACCCTTCGCCCTCGTCCTAACACCCTGGCTTCAGTGCAACTCTTTTCCTTCAGCTGCAT
GTGATTTTGTGATAAAGTTCAGGTAACAGGATGGGCAGTGATGGAGAATCACTGTTGATTGAGATTTTGGTTTCCATGTGATTTGTTTTC
TTCAATAGTCTTATTTTCAGTCTCTCAAATACAGCCAACTTAAAGTTTTAGTTTGGTGTTTATTGAAAATTAACCAAACTTAATACTAGG
AGAAGACTGAATCATTAATGATGTCTCACAAATTACTGTGTACCTAAGTGGTGTGATGTAAATACTGGAAACAAAAACAGCAGTTGCATT
GATTTTGAAAACAAACCCCCTTGTTATCTGAACATGTTTTCTTCAGGAACAACCAGAGGTATCACAAACACTGTTACTCATCTACTGGCT
CAGACTGTACTACTTTTTTTTTTTTTTTTCCTGAAAAAGAAACCAGAAAAAAATGTACTCTTACTGAGATACCCTCTCACCCCAAATGTG
TAATGGAAAATTTTTAATTAAGAAAAACTTCAGTTTTGCCAAGTGCAATGGTGTTGCCTTCTTTAAAAAATGCCGTTTTCTTACACTACC
AGTGGATGTCCAGACATGCTCTTAGTCTACTAGAGAGGTGCTGCCTTTTCTAAGTCATAATGAGGAACAGTCCCTTAATTTCTTGTGTGC
AACTCTGTTTTATCCTAGAACTAAGAGAGCATTGGTTTGTTAAAGAGCTTTCAATGTATATTAAAACCTTCAATACTCAGAAATGATGGA
TTCCTCCAAGGAGTCCTTTACTAGCCTAAACATTCTCAAATGTTTGAGATTCAAGTGAATGGAAGGAAAACCACATGCCTTTAAAACTAA
ACTGTAATAATTACCTGGCTAATTTCAGCTAAGCCTTCATCATAATTTGTTCCCTCAGTAATAGGAGAAATATAAATACAGTAAGTTTAG
ATTATTGAATTGGTGCTTGAAATTTATTGGTTTTGTTGTAATTTTATACAGATTATATGAGGGATAAGATACTCATCAAATTGCAAATTC
TTTTTTTTACAGAAGTGTGGGTAACAGTCACAGCAGTTTTTTTTACCAACAGCATACTTAACAGACTTGCTGTGTAGCAGTTTTTTTCTG
GTGGAGTTGCTGTAAGTCTTGTAAGTCTAATGTGGCTATCCTACTCTTTTGGGCAATGCATGTATTATGCATTGGAAAGGTATTTTTTTT
AAGTTCTGTTGGCTAGCTATGGTTTTCAGTACATTTCCTACTTTAAGAGTAATTACTGACAAATATGTATTTCCTATATGTTTATACTTT
GATTATAAAAAAGTATTTTGTTTTGATTTTTTAACTTGCTGCATTGTTTTGATACTTTCTATTTTTTTGGTCAAATCATGTTTAGAAACT
TTGGATGAGTTAAGAAGTCTTAAGTATGCAGGCGTTTACGTGATTGTGCCATTCCAAAGTGCATCAGAACTGTCATTCCCTTCTAATATC
TTCTCAGGAGTAATACAAATCAGGTATTTCATCATCATTTGGTAATATGAAAACTCCAGTGAACTCCCAAGGACATTTACAACATTTATA
TTCACACGCTGTATGGAAGGGTGTGGGTGTGTGTGAAGGGGCGAGTGGAGACACTGTGTGTATCTCTAGATAAGAAGATATGCACCACGT
TGAAAATACTCAGTGTAGATCTCTATGTGTATAGGTATCTGTATATCTTTCCTTTTGTTTACAACTGTTAAAAAACCTCAAAATAGTTCT
CTTCAAAAGAAGAGAGATTCCAAGCAACCCATCTTTCTTCAGTATGTATGTTCTGTACATACTTATCGGAGCGCGCCAGTAAGTATCAGG
CATATATATCTGTCTGTTAGCAATGATTATTACATCATCAGATCAGCATGTGCTATACTCCCTGCAAGAAATATACTGACATGAACAGGC
AGTTCTTGGAGAAGAAAGAGCATTTCTTTAAGTACCTGGGGAATACAGCTCTCAGTGATCAGCAGGGAGTTTATTTGAGGACATCAGTCA
CCTTTGGGGTTGCCATGTACAATGAGATTTATAATCATGATACTCTTCGGTGGTAGTTTCAAAAGACACTACTAATACGCAGGAAGCGTT
CCAGCTATTTAATGCTGGCAACTACTGTTTAATGGTCAGTTAAATCTGTGATAATGGTTGGAAGTGGGTGGGGTTATGAAATTGTAGATG
TTTTTAGAAAAACTTGTGAATGAAAATGAATCCAAGTGTTTCATGTGAAGATGTTGAGCCATTGCTATCATGCATTCCTGTCTCATGGCA

>In-frame_ENST00000415080_ENST00000318522_TCGA-66-2756-01A_THADA_chr2_43571261_-_EML4_chr2_42556026_length(amino acids)=1425AA_start in transcript=140_stop in transcript=4417
MGVKKKKEMQVAALTICHQDLETLKSFADVEGKNLASLLLHCVQLTDGVSQIHYIKQIVPLLEKADKNGMCDPTIQSCLDILAGIYLSLS
LKNPLKKVLASSLNSLPDFFLPEAMHRFTSRLQEELNTTDLYSYRKVTDNISSCMENFNLGRASVNNLLKNVLHFLQKSLIEILEENRKC
AGNHIIQTQLMNDLLVGIRVSMMLVQKVQDFQGNLWKTSDSPIWQNMCGLLSIFTKVLSDDDLLQTVQSTSGLAIILFIKTMFHPSEKIP
HLISSVLLRSVDCTSVPEWFMSSCRSLCCGDISQSAVLFLCQGTLAMLDWQNGSMGRSGEALLLDTAHVLFTLSSQIKEPTLEMFLSRIL
ASWTNSAIQVLESSSPSLTDSLNGNSSIVGRLLEYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVEGADFVPDPFFVELTESLLRLEWH
IKGKYTCLGCLVECIGVEHILAIDKTIPSQILEVMGDQSLVPYASDLLETMFRNHKSHLKSQTAESSWIDQWHETWVSPLLFILCEGNLD
QKSYVIDYYLPKLLSYSPESLQYMVKILQTSIDAKTGQEQSFPSLGSCNSRGALGALMACLRIARAHGHLQSATDTWENLVSDARIKQGL
IHQHCQVRIDTLGLLCESNRSTEIVSMEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKLEQSKSKREPENELTKQH
PSVSLQQYKNFMSSICNSLFEALFPGSSYSTRFSALTILGSIAEVFHVPEGRIYTVYQLSHDIDVGRFQTLMECFTSTFEDVKILAFDLL
MKLSKTAVHFQDSGKLQGLFQAALELSTSTKPYDCVTASYLLNFLIWQDALPSSLSAYLTQQVACDNGDRPAAVVERNTLMVIKCLMENL
EEEVSQAENSLLQAAAAFPMYGRVHCITGALQKLSLNSLQLVSEWRPVVEKLLLMSYRLSTVVSPVIQSSSPEGLIPMDTDSESASRLQM
ILNEIQPRDTNDYFNQAKILKEHDSFDMKDLNASVVNIDTSTEIKGKEVKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPMQPVPESS
DGLLTVEQVKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQA
LLASEPKKGRMDLLKITMKELISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWASQMTGREFFSRF
PELYPFLLKQLETVANTVDSDMGEPNRHPSMFLLLLVLERLYASPMDGTSSALSMGPFVPFIMRCGHSPVYHSREMAARALVPFVMIDHI

--------------------------------------------------------------
>In-frame_ENST00000415080_ENST00000402711_TCGA-66-2756-01A_THADA_chr2_43571261_-_EML4_chr2_42556026_length(transcript)=5538nt_BP=4396nt
GACCCGGTAGTCGACCGTGGACCGCGCTGCGAGCCTCGGAGACGCCGTAGAAGGAGACCTGCTTCCGGGACTGGACCAGGCGCCTGCGAC
TCTTCTCAGACGCCGACGTGCACGAGTGACTACTATTAATTCTATTTAAAATGGGTGTAAAGAAGAAGAAAGAAATGCAAGTTGCTGCGC
TGACCATTTGCCATCAGGACCTTGAAACTTTGAAATCTTTTGCTGATGTGGAAGGGAAAAATCTAGCTTCTTTGCTGTTACATTGTGTGC
AACTCACGGATGGAGTGTCACAAATCCATTATATTAAACAGATTGTGCCTCTGCTGGAGAAAGCAGATAAAAATGGCATGTGTGATCCCA
CTATTCAAAGTTGTTTGGATATCTTAGCAGGCATTTATCTTTCTTTGAGTCTAAAGAATCCCTTGAAGAAAGTATTGGCAAGCTCACTAA
ATAGCCTGCCTGATTTTTTTCTACCTGAGGCTATGCACCGTTTTACTTCTCGTCTTCAGGAAGAATTGAATACTACTGACTTATACTCTT
ACAGGAAAGTTACTGACAATATTTCTTCCTGTATGGAGAACTTTAACTTGGGTAGAGCAAGTGTTAATAATCTGCTTAAAAATGTGCTTC
ATTTTCTGCAGAAGAGTTTAATTGAAATCCTGGAAGAAAATAGAAAATGTGCTGGAAATCATATTATTCAAACACAGTTGATGAATGACT
TACTGGTAGGCATTAGAGTTTCAATGATGTTAGTACAGAAAGTACAAGATTTCCAGGGAAATCTTTGGAAGACTTCCGATTCTCCCATAT
GGCAAAATATGTGTGGATTGCTGAGTATTTTTACCAAGGTTTTAAGCGATGATGATCTGTTACAGACTGTACAGAGCACATCTGGATTAG
CTATTATTCTTTTTATTAAGACTATGTTTCACCCGTCTGAAAAGATTCCTCATTTGATTAGCAGTGTGCTGCTTCGTTCAGTGGACTGCA
CCAGTGTCCCCGAGTGGTTTATGAGCAGCTGCAGGAGCCTCTGTTGTGGTGACATCTCTCAGTCAGCTGTCTTATTCCTCTGTCAGGGGA
CACTTGCCATGTTGGACTGGCAGAACGGAAGCATGGGTCGGAGTGGGGAGGCCCTGCTCTTGGATACTGCACATGTTTTGTTCACCTTGA
GTTCACAGATTAAAGAGCCAACGCTGGAAATGTTTCTGTCTAGAATCTTAGCATCCTGGACTAATTCAGCCATACAAGTCCTTGAATCAA
GTTCCCCGAGCCTAACGGACAGCCTGAATGGGAATTCAAGTATAGTTGGGAGACTTTTGGAATATGTCTATACCCATTGGGAACATCCAT
TGGATGCTCTGAGACACCAAACCAAAATCATGTTCAAAAACCTTCTCCAAATGCACCGGCTCACTGTGGAAGGTGCAGATTTCGTCCCTG
ATCCTTTCTTTGTGGAATTGACTGAGAGTCTTTTACGATTGGAATGGCATATTAAAGGAAAGTACACGTGCCTTGGTTGTTTGGTAGAGT
GCATAGGAGTTGAACATATTTTGGCTATAGATAAAACTATTCCATCTCAAATCTTAGAGGTGATGGGAGACCAGTCATTGGTACCTTATG
CAAGTGACCTCTTGGAAACCATGTTTAGAAATCATAAGAGTCATTTGAAATCCCAGACTGCTGAGAGTTCTTGGATTGACCAGTGGCATG
AGACTTGGGTTTCTCCTCTCCTTTTTATATTGTGTGAAGGAAACTTGGATCAAAAATCTTACGTGATTGATTATTACTTGCCAAAATTAT
TAAGTTACAGCCCTGAAAGCTTACAGTACATGGTAAAGATTCTTCAGACTTCTATTGATGCTAAAACTGGACAAGAGCAATCTTTCCCAT
CCTTAGGGTCTTGTAATAGCAGGGGGGCTCTGGGAGCTTTGATGGCATGTCTGCGAATAGCTAGAGCTCATGGACATCTTCAGTCTGCAA
CTGATACCTGGGAGAACCTCGTGTCTGATGCAAGAATAAAGCAAGGCTTAATTCATCAGCATTGCCAAGTAAGGATAGATACATTAGGCT
TGCTTTGTGAAAGTAATCGGAGCACAGAAATTGTTTCCATGGAAGAAATGCAGTGGATTCAGTTCTTTATTACATACAATCTTAACAGCC
AGTCTCCAGGAGTGCGGCAACAGATCTGTTCTCTTCTTAAAAAGTTGTTTTGTAGGATACAGGAAAGTTCTCAGGTACTTTATAAATTGG
AGCAGAGTAAATCCAAACGTGAACCAGAGAATGAGTTAACCAAACAGCACCCTTCTGTTTCTTTACAGCAGTATAAGAATTTCATGTCAT
CCATTTGTAACAGTCTTTTTGAAGCATTGTTTCCTGGATCTTCCTACTCGACTAGATTTTCAGCTTTAACCATTTTAGGTTCAATAGCTG
AAGTTTTTCATGTCCCAGAAGGCAGAATTTATACAGTATATCAGCTGAGTCATGATATTGATGTTGGTCGTTTCCAAACACTAATGGAAT
GTTTTACCAGCACTTTTGAAGACGTGAAAATTTTAGCATTTGATCTTCTGATGAAGTTATCAAAAACAGCTGTACATTTTCAGGATTCGG
GGAAACTGCAAGGCTTATTTCAGGCAGCATTGGAGCTCAGCACAAGCACCAAACCATACGACTGTGTGACAGCTTCCTACCTGCTGAACT
TCTTAATCTGGCAGGATGCTCTACCGTCATCCTTGTCTGCCTACTTAACTCAGCAAGTTGCATGTGATAATGGAGATAGGCCTGCTGCTG
TGGTGGAAAGGAACACATTAATGGTTATCAAATGCTTGATGGAAAATCTTGAGGAAGAAGTATCTCAGGCTGAAAATTCTCTGCTTCAGG
CAGCAGCAGCATTTCCAATGTATGGGCGAGTCCACTGTATAACAGGAGCTTTGCAGAAGTTATCTCTAAACAGCCTGCAGTTGGTGAGCG
AGTGGAGACCTGTGGTAGAGAAGCTCCTTTTGATGTCCTACAGGCTTTCCACTGTGGTGTCTCCAGTCATTCAGAGCTCATCCCCTGAAG
GCCTCATCCCAATGGACACTGATTCAGAGTCAGCAAGCCGCTTACAGATGATTCTGAATGAGATTCAGCCTCGAGATACTAATGATTATT
TTAACCAAGCCAAAATATTGAAAGAACATGATAGCTTTGATATGAAGGACTTGAATGCTAGTGTGGTGAATATTGATACTTCTACAGAAA
TCAAAGGTAAAGAAGTAAAAACATGTGATGTAACTGCGCAGATGGTGCTGGTATGTTGTTGGAGAAGTATGAAGGAAGTTGCTTTACTTT
TAGGCATGTTGTGCCAGCTTCTGCCCATGCAGCCTGTGCCAGAATCTTCTGATGGATTATTGACGGTGGAGCAGGTAAAAGAAATAGGAG
ATTACTTTAAACAACACCTTTTGCAGTCCAGGCACAGAGGAGCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAA
ACAGGTGCCCAAATGTGAGTCTGCAAAAGCTGCCAGAACAGTGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTA
AACTCTGTGCTACAAGGCGCAGTGCTGGAATTCCTTTCTACATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGT
TGAAAATAACAATGAAAGAGTTAATCTCTTTGGCTGGGCCTACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCC
TTAGAGCATTGTTCAGAGATACGCGCCTGGGAGAAAATATTATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACAT
CACCGGTCTGGGCATCTCAAATGACAGGGAGAGAGTTTTTCTCTCGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTG
TAGCCAATACAGTAGACAGTGATATGGGAGAACCAAATCGTCATCCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTT
CCCCGATGGATGGTACTTCTTCTGCTCTCAGCATGGGACCTTTTGTTCCCTTCATTATGAGGTGTGGTCACTCACCTGTCTACCACTCCC
GTGAAATGGCAGCTCGTGCCTTGGTCCCATTTGTTATGATAGATCACATTCCTAATACCATTCGAACTCTGTTGTCCACACTCCCCAGCT
GCACTGACCAGTGTTTCCGGCAAAACCACATTCATGGGACACTTCTCCAGGTTTTTCATTTGTTGCAAGCCTACTCAGACTCCAAACACG
GAACGAATTCAGACTTCCAGCACGAGCTGACTGACATCACTGTTTGTACCAAAGCCAAACTCTGGCTGGCCAAGAGGTGTCTGGCCAGAA
GGATCTGATGGGACAGATATCAATGCACTGGTGCGATCCCACAATAGAAAGGTGATAGCTGTTGCCGATGACTTTTGTAAAGTCCATCTG
TTTCAGTATCCCTGCTCCAAAGCAAAGGCTCCCAGTCACAAGTACAGTGCCCACAGCAGCCATGTCACCAATGTCAGTTTTACTCACAAT
GACAGTCACCTGATATCAACTGGTGGAAAAGACATGAGCATCATTCAGTGGAAACTTGTGGAAAAGTTATCTTTGCCTCAGAATGAGACT
GTAGCGGATACTACTCTAACCAAAGCCCCCGTCTCTTCCACTGAAAGTGTCATCCAATCTAATACTCCCACACCGCCTCCTTCTCAGCCC
TTAAATGAGACAGCTGAAGAGGAAAGTAGAATAAGCAGTTCTCCCACACTTCTGGAGAACAGCCTGGAACAAACTGTGGAGCCAAGTGAA
GACCACAGCGAGGAGGAGAGTGAAGAGGGCAGCGGAGACCTTGGTGAGCCTCTTTATGAAGAGCCATGCAACGAGATAAGCAAGGAGCAG
GCCAAAGCCACCCTTCTGGAGGACCAGCAAGACCCTTCGCCCTCGTCCTAACACCCTGGCTTCAGTGCAACTCTTTTCCTTCAGCTGCAT
GTGATTTTGTGATAAAGTTCAGGTAACAGGATGGGCAGTGATGGAGAATCACTGTTGATTGAGATTTTGGTTTCCATGTGATTTGTTTTC
TTCAATAGTCTTATTTTCAGTCTCTCAAATACAGCCAACTTAAAGTTTTAGTTTGGTGTTTATTGAAAATTAACCAAACTTAATACTAGG
AGAAGACTGAATCATTAATGATGTCTCACAAATTACTGTGTACCTAAGTGGTGTGATGTAAATACTGGAAACAAAAACAGCAGTTGCATT
GATTTTGAAAACAAACCCCCTTGTTATCTGAACATGTTTTCTTCAGGAACAACCAGAGGTATCACAAACACTGTTACTCATCTACTGGCT
CAGACTGTACTACTTTTTTTTTTTTTTTTCCTGAAAAAGAAACCAGAAAAAAATGTACTCTTACTGAGATACCCTCTCACCCCAAATGTG

>In-frame_ENST00000415080_ENST00000402711_TCGA-66-2756-01A_THADA_chr2_43571261_-_EML4_chr2_42556026_length(amino acids)=1425AA_start in transcript=140_stop in transcript=4417
MGVKKKKEMQVAALTICHQDLETLKSFADVEGKNLASLLLHCVQLTDGVSQIHYIKQIVPLLEKADKNGMCDPTIQSCLDILAGIYLSLS
LKNPLKKVLASSLNSLPDFFLPEAMHRFTSRLQEELNTTDLYSYRKVTDNISSCMENFNLGRASVNNLLKNVLHFLQKSLIEILEENRKC
AGNHIIQTQLMNDLLVGIRVSMMLVQKVQDFQGNLWKTSDSPIWQNMCGLLSIFTKVLSDDDLLQTVQSTSGLAIILFIKTMFHPSEKIP
HLISSVLLRSVDCTSVPEWFMSSCRSLCCGDISQSAVLFLCQGTLAMLDWQNGSMGRSGEALLLDTAHVLFTLSSQIKEPTLEMFLSRIL
ASWTNSAIQVLESSSPSLTDSLNGNSSIVGRLLEYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVEGADFVPDPFFVELTESLLRLEWH
IKGKYTCLGCLVECIGVEHILAIDKTIPSQILEVMGDQSLVPYASDLLETMFRNHKSHLKSQTAESSWIDQWHETWVSPLLFILCEGNLD
QKSYVIDYYLPKLLSYSPESLQYMVKILQTSIDAKTGQEQSFPSLGSCNSRGALGALMACLRIARAHGHLQSATDTWENLVSDARIKQGL
IHQHCQVRIDTLGLLCESNRSTEIVSMEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKLEQSKSKREPENELTKQH
PSVSLQQYKNFMSSICNSLFEALFPGSSYSTRFSALTILGSIAEVFHVPEGRIYTVYQLSHDIDVGRFQTLMECFTSTFEDVKILAFDLL
MKLSKTAVHFQDSGKLQGLFQAALELSTSTKPYDCVTASYLLNFLIWQDALPSSLSAYLTQQVACDNGDRPAAVVERNTLMVIKCLMENL
EEEVSQAENSLLQAAAAFPMYGRVHCITGALQKLSLNSLQLVSEWRPVVEKLLLMSYRLSTVVSPVIQSSSPEGLIPMDTDSESASRLQM
ILNEIQPRDTNDYFNQAKILKEHDSFDMKDLNASVVNIDTSTEIKGKEVKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPMQPVPESS
DGLLTVEQVKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQA
LLASEPKKGRMDLLKITMKELISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWASQMTGREFFSRF
PELYPFLLKQLETVANTVDSDMGEPNRHPSMFLLLLVLERLYASPMDGTSSALSMGPFVPFIMRCGHSPVYHSREMAARALVPFVMIDHI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for THADA-EML4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for THADA-EML4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for THADA-EML4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTHADAC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneEML4C0007131Non-Small Cell Lung Carcinoma6CTD_human
TgeneEML4C0027627Neoplasm Metastasis2CTD_human
TgeneEML4C0152013Adenocarcinoma of lung (disorder)2CTD_human
TgeneEML4C0006118Brain Neoplasms1CTD_human
TgeneEML4C0153633Malignant neoplasm of brain1CTD_human
TgeneEML4C0496899Benign neoplasm of brain, unspecified1CTD_human
TgeneEML4C0750974Brain Tumor, Primary1CTD_human
TgeneEML4C0750977Recurrent Brain Neoplasm1CTD_human
TgeneEML4C0750979Primary malignant neoplasm of brain1CTD_human
TgeneEML4C1527390Neoplasms, Intracranial1CTD_human