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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:THADA-MTA3 (FusionGDB2 ID:89937)

Fusion Gene Summary for THADA-MTA3

check button Fusion gene summary
Fusion gene informationFusion gene name: THADA-MTA3
Fusion gene ID: 89937
HgeneTgene
Gene symbol

THADA

MTA3

Gene ID

63892

57504

Gene nameTHADA armadillo repeat containingmetastasis associated 1 family member 3
SynonymsARMC13|GITA-
Cytomap

2p21

2p21

Type of geneprotein-codingprotein-coding
Descriptionthyroid adenoma-associated proteindeath receptor-interacting proteingene inducing thyroid adenomas proteinmetastasis-associated protein MTA3metastasis associated gene family, member 3
Modification date2020031320200313
UniProtAcc.

Q9BTC8

Ensembl transtripts involved in fusion geneENST00000330266, ENST00000405975, 
ENST00000415080, ENST00000405006, 
ENST00000485353, ENST00000402360, 
ENST00000404790, ENST00000403856, 
ENST00000405592, ENST00000406652, 
ENST00000407270, ENST00000406911, 
ENST00000405094, ENST00000472767, 
Fusion gene scores* DoF score16 X 16 X 12=307210 X 10 X 5=500
# samples 1811
** MAII scorelog2(18/3072*10)=-4.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/500*10)=-2.18442457113743
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: THADA [Title/Abstract] AND MTA3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTHADA(43655239)-MTA3(42931337), # samples:1
Anticipated loss of major functional domain due to fusion event.THADA-MTA3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
THADA-MTA3 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across THADA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MTA3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GN-01ATHADAchr2

43655239

-MTA3chr2

42931337

+


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Fusion Gene ORF analysis for THADA-MTA3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000330266ENST00000405592THADAchr2

43655239

-MTA3chr2

42931337

+
In-frameENST00000330266ENST00000406652THADAchr2

43655239

-MTA3chr2

42931337

+
In-frameENST00000330266ENST00000407270THADAchr2

43655239

-MTA3chr2

42931337

+
In-frameENST00000330266ENST00000406911THADAchr2

43655239

-MTA3chr2

42931337

+
In-frameENST00000330266ENST00000405094THADAchr2

43655239

-MTA3chr2

42931337

+
5CDS-3UTRENST00000330266ENST00000472767THADAchr2

43655239

-MTA3chr2

42931337

+
Frame-shiftENST00000405975ENST00000405592THADAchr2

43655239

-MTA3chr2

42931337

+
Frame-shiftENST00000405975ENST00000406652THADAchr2

43655239

-MTA3chr2

42931337

+
Frame-shiftENST00000405975ENST00000407270THADAchr2

43655239

-MTA3chr2

42931337

+
Frame-shiftENST00000405975ENST00000406911THADAchr2

43655239

-MTA3chr2

42931337

+
Frame-shiftENST00000405975ENST00000405094THADAchr2

43655239

-MTA3chr2

42931337

+
5CDS-3UTRENST00000405975ENST00000472767THADAchr2

43655239

-MTA3chr2

42931337

+
Frame-shiftENST00000415080ENST00000405592THADAchr2

43655239

-MTA3chr2

42931337

+
Frame-shiftENST00000415080ENST00000406652THADAchr2

43655239

-MTA3chr2

42931337

+
Frame-shiftENST00000415080ENST00000407270THADAchr2

43655239

-MTA3chr2

42931337

+
Frame-shiftENST00000415080ENST00000406911THADAchr2

43655239

-MTA3chr2

42931337

+
Frame-shiftENST00000415080ENST00000405094THADAchr2

43655239

-MTA3chr2

42931337

+
5CDS-3UTRENST00000415080ENST00000472767THADAchr2

43655239

-MTA3chr2

42931337

+
Frame-shiftENST00000405006ENST00000405592THADAchr2

43655239

-MTA3chr2

42931337

+
Frame-shiftENST00000405006ENST00000406652THADAchr2

43655239

-MTA3chr2

42931337

+
Frame-shiftENST00000405006ENST00000407270THADAchr2

43655239

-MTA3chr2

42931337

+
Frame-shiftENST00000405006ENST00000406911THADAchr2

43655239

-MTA3chr2

42931337

+
Frame-shiftENST00000405006ENST00000405094THADAchr2

43655239

-MTA3chr2

42931337

+
5CDS-3UTRENST00000405006ENST00000472767THADAchr2

43655239

-MTA3chr2

42931337

+
5UTR-3CDSENST00000485353ENST00000405592THADAchr2

43655239

-MTA3chr2

42931337

+
5UTR-3CDSENST00000485353ENST00000406652THADAchr2

43655239

-MTA3chr2

42931337

+
5UTR-3CDSENST00000485353ENST00000407270THADAchr2

43655239

-MTA3chr2

42931337

+
5UTR-3CDSENST00000485353ENST00000406911THADAchr2

43655239

-MTA3chr2

42931337

+
5UTR-3CDSENST00000485353ENST00000405094THADAchr2

43655239

-MTA3chr2

42931337

+
5UTR-3UTRENST00000485353ENST00000472767THADAchr2

43655239

-MTA3chr2

42931337

+
intron-3CDSENST00000402360ENST00000405592THADAchr2

43655239

-MTA3chr2

42931337

+
intron-3CDSENST00000402360ENST00000406652THADAchr2

43655239

-MTA3chr2

42931337

+
intron-3CDSENST00000402360ENST00000407270THADAchr2

43655239

-MTA3chr2

42931337

+
intron-3CDSENST00000402360ENST00000406911THADAchr2

43655239

-MTA3chr2

42931337

+
intron-3CDSENST00000402360ENST00000405094THADAchr2

43655239

-MTA3chr2

42931337

+
intron-3UTRENST00000402360ENST00000472767THADAchr2

43655239

-MTA3chr2

42931337

+
intron-3CDSENST00000404790ENST00000405592THADAchr2

43655239

-MTA3chr2

42931337

+
intron-3CDSENST00000404790ENST00000406652THADAchr2

43655239

-MTA3chr2

42931337

+
intron-3CDSENST00000404790ENST00000407270THADAchr2

43655239

-MTA3chr2

42931337

+
intron-3CDSENST00000404790ENST00000406911THADAchr2

43655239

-MTA3chr2

42931337

+
intron-3CDSENST00000404790ENST00000405094THADAchr2

43655239

-MTA3chr2

42931337

+
intron-3UTRENST00000404790ENST00000472767THADAchr2

43655239

-MTA3chr2

42931337

+
intron-3CDSENST00000403856ENST00000405592THADAchr2

43655239

-MTA3chr2

42931337

+
intron-3CDSENST00000403856ENST00000406652THADAchr2

43655239

-MTA3chr2

42931337

+
intron-3CDSENST00000403856ENST00000407270THADAchr2

43655239

-MTA3chr2

42931337

+
intron-3CDSENST00000403856ENST00000406911THADAchr2

43655239

-MTA3chr2

42931337

+
intron-3CDSENST00000403856ENST00000405094THADAchr2

43655239

-MTA3chr2

42931337

+
intron-3UTRENST00000403856ENST00000472767THADAchr2

43655239

-MTA3chr2

42931337

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000330266THADAchr243655239-ENST00000405592MTA3chr242931337+74933188039441314
ENST00000330266THADAchr243655239-ENST00000406652MTA3chr242931337+74933188039441314
ENST00000330266THADAchr243655239-ENST00000407270MTA3chr242931337+41363188037101236
ENST00000330266THADAchr243655239-ENST00000406911MTA3chr242931337+41333188037071235
ENST00000330266THADAchr243655239-ENST00000405094MTA3chr242931337+39483188039471315

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000330266ENST00000405592THADAchr243655239-MTA3chr242931337+0.0005367040.99946326
ENST00000330266ENST00000406652THADAchr243655239-MTA3chr242931337+0.0005367040.99946326
ENST00000330266ENST00000407270THADAchr243655239-MTA3chr242931337+0.0002602250.9997398
ENST00000330266ENST00000406911THADAchr243655239-MTA3chr242931337+0.000177380.9998227
ENST00000330266ENST00000405094THADAchr243655239-MTA3chr242931337+0.0005697840.99943024

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Fusion Genomic Features for THADA-MTA3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
THADAchr243655238-MTA3chr242931333+6.23E-050.99993765
THADAchr243655238-MTA3chr242931333+6.23E-050.99993765

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for THADA-MTA3


check button Go to

FGviewer for the breakpoints of chr2:43655239-chr2:42931337

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MTA3

Q9BTC8

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6. {ECO:0000269|PubMed:12705869, ECO:0000269|PubMed:15454082}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHADAchr2:43655239chr2:42931337ENST00000405006-2838886_9181352.66666666666671954.0Coiled coilOntology_term=ECO:0000255
HgeneTHADAchr2:43655239chr2:42931337ENST00000405975-2838886_9181352.66666666666671954.0Coiled coilOntology_term=ECO:0000255
HgeneTHADAchr2:43655239chr2:42931337ENST00000405006-28381322_13271352.66666666666671954.0Compositional biasNote=Poly-Leu
HgeneTHADAchr2:43655239chr2:42931337ENST00000405006-28384_71352.66666666666671954.0Compositional biasNote=Poly-Lys
HgeneTHADAchr2:43655239chr2:42931337ENST00000405975-28381322_13271352.66666666666671954.0Compositional biasNote=Poly-Leu
HgeneTHADAchr2:43655239chr2:42931337ENST00000405975-28384_71352.66666666666671954.0Compositional biasNote=Poly-Lys
TgeneMTA3chr2:43655239chr2:42931337ENST000004050941017379_406341.6666666666667595.0Zinc fingerNote=GATA-type%3B atypical
TgeneMTA3chr2:43655239chr2:42931337ENST000004072701014379_406341.6666666666667516.0Zinc fingerNote=GATA-type%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHADAchr2:43655239chr2:42931337ENST00000402360-117886_9180938.0Coiled coilOntology_term=ECO:0000255
HgeneTHADAchr2:43655239chr2:42931337ENST00000402360-1171322_13270938.0Compositional biasNote=Poly-Leu
HgeneTHADAchr2:43655239chr2:42931337ENST00000402360-1171529_15320938.0Compositional biasNote=Poly-Ala
HgeneTHADAchr2:43655239chr2:42931337ENST00000402360-1174_70938.0Compositional biasNote=Poly-Lys
HgeneTHADAchr2:43655239chr2:42931337ENST00000405006-28381529_15321352.66666666666671954.0Compositional biasNote=Poly-Ala
HgeneTHADAchr2:43655239chr2:42931337ENST00000405975-28381529_15321352.66666666666671954.0Compositional biasNote=Poly-Ala
TgeneMTA3chr2:43655239chr2:42931337ENST000004050941017148_259341.6666666666667595.0DomainELM2
TgeneMTA3chr2:43655239chr2:42931337ENST0000040509410171_147341.6666666666667595.0DomainBAH
TgeneMTA3chr2:43655239chr2:42931337ENST000004050941017266_318341.6666666666667595.0DomainSANT
TgeneMTA3chr2:43655239chr2:42931337ENST000004072701014148_259341.6666666666667516.0DomainELM2
TgeneMTA3chr2:43655239chr2:42931337ENST0000040727010141_147341.6666666666667516.0DomainBAH
TgeneMTA3chr2:43655239chr2:42931337ENST000004072701014266_318341.6666666666667516.0DomainSANT


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Fusion Gene Sequence for THADA-MTA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000330266_ENST00000405592_TCGA-HU-A4GN-01A_THADA_chr2_43655239_-_MTA3_chr2_42931337_length(transcript)=7493nt_BP=3188nt
ATGAGCAGCTGCAGGAGCCTCTGTTGTGGTGACATCTCTCAGTCAGCTGTCTTATTCCTCTGTCAGGGGACACTTGCCATGTTGGACTGG
CAGAACGGAAGCATGGGTCGGAGTGGGGAGGCCCTGCTCTTGGATACTGCACATGTTTTGTTCACCTTGAGTTCACAGATTAAAGAGCCA
ACGCTGGAAATGTTTCTGTCTAGAATCTTAGCATCCTGGACTAATTCAGCCATACAAGTCCTTGAATCAAGTTCCCCGAGCCTAACGGAC
AGCCTGAATGGGAATTCAAGTATAGTTGGGAGACTTTTGGAATATGTCTATACCCATTGGGAACATCCATTGGATGCTCTGAGACACCAA
ACCAAAATCATGTTCAAAAACCTTCTCCAAATGCACCGGCTCACTGTGGAAGGTGCAGATTTCGTCCCTGATCCTTTCTTTGTGGAATTG
ACTGAGAGTCTTTTACGATTGGAATGGCATATTAAAGGAAAGTACACGTGCCTTGGTTGTTTGGTAGAGTGCATAGGAGTTGAACATATT
TTGGCTATAGATAAAACTATTCCATCTCAAATCTTAGAGGTGATGGGAGACCAGTCATTGGTACCTTATGCAAGTGACCTCTTGGAAACC
ATGTTTAGAAATCATAAGAGTCATTTGAAATCCCAGACTGCTGAGAGTTCTTGGATTGACCAGTGGCATGAGACTTGGGTTTCTCCTCTC
CTTTTTATATTGTGTGAAGGAAACTTGGATCAAAAATCTTACGTGATTGATTATTACTTGCCAAAATTATTAAGTTACAGCCCTGAAAGC
TTACAGTACATGGTAAAGATTCTTCAGACTTCTATTGATGCTAAAACTGGACAAGAGCAATCTTTCCCATCCTTAGGGTCTTGTAATAGC
AGGGGGGCTCTGGGAGCTTTGATGGCATGTCTGCGAATAGCTAGAGCTCATGGACATCTTCAGTCTGCAACTGATACCTGGGAGAACCTC
GTGTCTGATGCAAGAATAAAGCAAGGCTTAATTCATCAGCATTGCCAAGTAAGGATAGATACATTAGGCTTGCTTTGTGAAAGTAATCGG
AGCACAGAAATTGTTTCCATGGAAGAAATGCAGTGGATTCAGTTCTTTATTACATACAATCTTAACAGCCAGTCTCCAGGAGTGCGGCAA
CAGATCTGTTCTCTTCTTAAAAAGTTGTTTTGTAGGATACAGGAAAGTTCTCAGGTACTTTATAAATTGGAGCAGAGTAAATCCAAACGT
GAACCAGAGAATGAGTTAACCAAACAGCACCCTTCTGTTTCTTTACAGCAGTATAAGAATTTCATGTCATCCATTTGTAACAGTCTTTTT
GAAGCATTGTTTCCTGGATCTTCCTACTCGACTAGATTTTCAGCTTTAACCATTTTAGGTTCAATAGCTGAAGTTTTTCATGTCCCAGAA
GGCAGAATTTATACAGTATATCAGCTGAGTCATGATATTGATGTTGGTCGTTTCCAAACACTAATGGAATGTTTTACCAGCACTTTTGAA
GACGTGAAAATTTTAGCATTTGATCTTCTGATGAAGTTATCAAAAACAGCTGTACATTTTCAGGATTCGGGGAAACTGCAAGGCTTATTT
CAGGCAGCATTGGAGCTCAGCACAAGCACCAAACCATACGACTGTGTGACAGCTTCCTACCTGCTGAACTTCTTAATCTGGCAGGATGCT
CTACCGTCATCCTTGTCTGCCTACTTAACTCAGCAAGTTGCATGTGATAATGGAGATAGGCCTGCTGCTGTGGTGGAAAGGAACACATTA
ATGGTTATCAAATGCTTGATGGAAAATCTTGAGGAAGAAGTATCTCAGGCTGAAAATTCTCTGCTTCAGGCAGCAGCAGCATTTCCAATG
TATGGGCGAGTCCACTGTATAACAGGAGCTTTGCAGAAGTTATCTCTAAACAGCCTGCAGTTGGTGAGCGAGTGGAGACCTGTGGTAGAG
AAGCTCCTTTTGATGTCCTACAGGCTTTCCACTGTGGTGTCTCCAGTCATTCAGAGCTCATCCCCTGAAGGCCTCATCCCAATGGACACT
GATTCAGAGTCAGCAAGCCGCTTACAGATGATTCTGAATGAGATTCAGCCTCGAGATACTAATGATTATTTTAACCAAGCCAAAATATTG
AAAGAACATGATAGCTTTGATATGAAGGACTTGAATGCTAGTGTGGTGAATATTGATACTTCTACAGAAATCAAAGGTAAAGAAGTAAAA
ACATGTGATGTAACTGCGCAGATGGTGCTGGTATGTTGTTGGAGAAGTATGAAGGAAGTTGCTTTACTTTTAGGCATGTTGTGCCAGCTT
CTGCCCATGCAGCCTGTGCCAGAATCTTCTGATGGATTATTGACGGTGGAGCAGGTAAAAGAAATAGGAGATTACTTTAAACAACACCTT
TTGCAGTCCAGGCACAGAGGAGCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAAACAGGTGCCCAAATGTGAGT
CTGCAAAAGCTGCCAGAACAGTGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTAAACTCTGTGCTACAAGGCGC
AGTGCTGGAATTCCTTTCTACATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGTTGAAAATAACAATGAAAGAG
TTAATCTCTTTGGCTGGGCCTACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCCTTAGAGCATTGTTCAGAGAT
ACGCGCCTGGGAGAAAATATTATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACATCACCGGTCTGGGCAGTGCGA
AATTCATCCACACTTCTCTTTAGTGCCTTGATCACAAGAATTTTTGGAGTTAAAAGGGCAAAGGATGAACATTCCAAAACAAATAGAATG
ACAGGGAGAGAGTTTTTCTCTCGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTGTAGCCAATACAGTAGACAGTGAT
ATGGGAGAACCAAATCGTCATCCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTTCCCCGATGGATGGTACTTCTTCT
GCTCTCAGCATGGGACCTTTTGTTCCCTTCATTATGAGCAAACCAAATCCCAACCAAATATCCACTAGTAATGGGAAGCCTGGTGCTGTG
AATGGAGCTGTGGGGACCACGTTCCAGCCTCAGAATCCTCTCTTAGGGAGAGCCTGTGAGAGCTGCTATGCTACACAGTCTCACCAGTGG
TATTCTTGGGGCCCACCTAATATGCAGTGTAGATTATGTGCAATTTGTTGGCTTTATTGGAAAAAATATGGAGGCTTGAAAATGCCCACC
CAGTCAGAAGAAGAGAAGTTATCTCCTAGCCCAACTACAGAGGACCCTCGTGTTAGAAGTCACGTGTCCCGCCAGGCCATGCAGGGAATG
CCAGTCCGAAACACTGGGAGTCCAAAGTCTGCAGTGAAGACCCGCCAAGCTTTCTTCCTTCATACTACATATTTCACAAAATTTGCTCGT
CAGGTCTGCAAAAATACCCTCCGGCTGCGGCAGGCAGCAAGACGGCCGTTTGTTGCTATTAATTATGCTGCCATTAGGGCAGAATATGCA
GACAGACATGCTGAACTATCTGGAAGTCCACTGAAAAGCAAAAGCACTAGGAAGCCTTTGGCATGTATCATTGGGTATTTAGAGATCCAT
CCTGCAAAGAAACCTAATGTAATTCGATCTACACCAAGCCTGCAAACCCCAACTACCAAGCGGATGCTAACAACTCCAAATCACACATCT
CTGAGCATTCTGGGGAAAAGAAACTACAGTCATCACAATGGTCTGGATGAACTCACGTGCTGTGTGTCAGACTGAGCTTTCCCTGATTCA
TTCTACAATCCAAGACTTGCTGCACTGTCCTGCTGATGTTCACAGCCGTGCCTGGGAAGAAGGCAGCCCCACTCCCAGTACATTTCAGTG
GGAGACCTCTGCGTGCATCCATGGAGACGCAATGGGGCGGGGAAGGAACTGTGGGAGTGCACGTTCCAAATCCTGTGTCTCCACGTGTGG
ATCAGCAGCACCTCGCTTTCTTGTCAGAGACCTCGCTGTTACGGAGCGAGACCTGCTGAGAATTGAGGGGCTGAGGGAACCCCTCCACCT
CCTCCCTTCTGCAGCGCCCTGCGCCCCACCCAGCAACAGCGGCCACTTGGCAGTGGGGCTGCTGCAAGCTCAGAGCCGCTGCCACCCTGC
ATGTGTCCGCTCAGCTCGGTCTTATGCTGTATAGTTACTAAATATGTACAGGAGGGCCATGGCATCTTTCTGAATGGATTTTTCTTAAGA
AATGCGCCAGTGTTTATGAGGTTCAAGGTATTTCCCTGTCCTTGCTGTTACCGTCACTCAGCTTTTTCTCGATAGGCTTCATCCTTGTTT
TTTTGAAATGGGGGAATTTGCTGTTTACCCTCTGCATTCCTATATGTGACCCTCCCTCCTACTCCTCCAAGGAACAGAATTACCGAGGTT
CTGACAAAAGATAAGCCTGTAAACTCATCATCTGTGTTTTGTGGTTGGAGAGAAACTGGTGTTCTGCCCGGCTCTGCTTGGTCACAGACA
GCTCCAGCAAGAGCAGTTGTTAAAAGTGCCAAGCGTGTGTATCACTGTGACAAGCCGTTTGCTTACTGCCCTGTTCCCTTGCAGCCAAAC
CAGCTGATGAAGAACTGCTGCCAGGTGGGTCCTACAGCAGGTCACAAATGACCTAGTTTCATTTTAAGCAGACAGACTCTGTTTGGCCTA
GAGGTGTGGAGTGAGAGAACTGTGTTTGTGGGTATGAGTCTGTGTGGCCAACCCCATGACCCCCACCCCTCCAGCCCAACATCTTGTGAG
CACATGTGACCTAGGCCCCGGGGGACCTGCCTGCTCCTTTGGCTTGGGCTCTTCGTGTTTCCCACCTGCCCTCGGCACGAGCCCTTGGTG
GCATCACAGTTGGCCACTCAGCTGTGCTGAGTAGCTGTGCTACTTGTGCTGGCAGCTGCAAGGATAGGAATAGCTCAGCGCCCGATGAGC
TCCCTGAGCAGATGTGAGGCTGGCAACTCCCCTGCCCTCTGTTTGCAGGCACAGGGTCACAGTCCCAAGAAAGACAACTGGAGTCTGATC
TCCCAGCCATCTCTGGGGTTACTAGGAGGCAGCTGGATGGCAGATACGAGAGGCCCAAATAGCCAAGCTGTTGCAAGACAGAGTGGCTAC
AATTGAATTGACACCCTGGGAAGCACGAGGTAACTTGGTAAGGATAATGATGCTGTAGATGTCTGTGTCCTCGGAGGCTGAGCTCCGCTT
GGCAGAGAGAGCGTGCTGTGTGAGGTGGAGGGCGGTTTTGCAGACATCTCAGCTTCTTTTCTGAGGAGGAGTTGGTTCTCATCTTAGGCT
TCTGCAAGGGCGAGCATGGGATGTCTCCACCACCACCCACTCTTGGAGCTGTGCTGGGTCTTGGCTTGGGGCGCTGAGGGTGGGGCCTGT
GTCAGAAGCATTTGGTGAGAGGGGTGGAGGTGGCAGGCAGGGGTTCTCCTCAGGGTTCCCACTGAGGGGTCCCTTCAGCAAAGACCTGGG
AGGAGGTGCCGCATCACGTGGATGTTTCTTCCCTAAAGAAAAAGACACAGGAAAGCTGTCTGTCTGTACCCTGCTCTGGATTTATTGTCG
TACTTGGACCCAGAAGGGGAAATGATTCCCTCACCCTTTCACTTTCTCTCTGAACCCCTACTAAGTGGTGACTGCAGATTCTGGAAACAA
TTAGCTGCCCGTGACTCAGCTGCCAGCTTCATTTTCTCTGCCTTTTGGGAGAGGCCCTCTCACCCAGGCCCAAGAGATTTGGAGACAGGA
GTCAGGCCAGGTCTGAAGCAGGAGAAGGGAGGCCCCTCCTATCTACCCAGTTGACATTTGGCTTTGGGAAAAGCGCAGCTTGTTCGAGCC
ACGTGTGCCAAGCAGGCTTTTCCTTCCTCTTGTAAGTAAAGCTCGTGGTTCTGTAGTCCAGTCATCCTAGGAGGGTGATGTTGACTGAGA
CTTCACGCTCTCCCTTTGTCTCTGGAAACTGCCCCCTCGTTCTGACAGAATCCCCCAGGCAATGGAGGAAGGGTGCCGAGGCGCCTCTAG
TCTGTGCCTTTGCCGTTGGAAGCATTTGGTGCTGAGAGGGTTTCCCAGCCACCCGCTCCCTTTCTGGGGCCATGGTGTCCCTGCTGTGTG
TCAGTGGCATGTCACTGTGGTTCAGTGAGCACATGGGTGGACGTGCAGAGACTGTCTGCGCAGCCCCCAGCAGACATGCCCCTGGGGTGA
GGACACAGGCTCTGCAGGCTATCTCCCCCTCTGGCTCAGTCATCGCCTGCCCACCCTTCACTTCTTAAAGGTGCGCAAGAGAGGAGGGCC
GACTGGAGGGTGTCGCCGGAAGGTTTCAGCCTGCCCTTCACAATTCCCCTTGTGCACAGCCCAGTTTCCATCTCTCAGGGCCCACCCAGG
AAAATGGATTTCAAGTGGGGGTTTTCATCCAGAGATTTGTTTAACACAAAACAAGAAAAGCTGAGAGGCAAAACAGGGGAGTGAGGGGCA
ACCCAGAGGTGGGGAACAACAACAGCAAGCCGCCCCCATCCTGAGACTGGCTGGGCACCAGGGGAGGACGCGTCACCAGAGCCTGGGGCC
AAGGCCACTGGGGGACCTGCCACACTGTGGACCTGTCTGGTGGGGGCTGGAGCCTCGAGAAGCCATGATTCTTGTCAGAAACATTTCCCC
AGGCAGAGAGAGGGGGCCCCAGCCTCTCCCCTCCTCTTGGCCTCCAGAGTCCTGCAGGTGCCTCACAGTAGTGAAACCCAGTTGGAAGCA
GCTGCCCTGGGAGCCTGGGACAGGCGACCCACCGGGTCAGTCCCCTGCCACTCAGAGCAGAGCAGGGGGCTGAGGGCAAGCAGGTGGGGC
TGTGCGTGGCCTCAGTGCACTCGGTGTCATGTCTGAGCCTGGTGTTTATGCCCCACTGCTGTCCTAAGTCCCTGGCGAGGGGAGGTGGAG
GAGCTGCCCCGTGGGTGTTTGGAGATTCTGTTTTACTCTGCCTAGAGAGGAAACGGCTTTGGGGAGGGAGGGGGAAGCCTTTATTCTTTA
CTGTTGTCCCTGTTTTCCTTTGGGGGAATTTACTCAGTTAGCAGCCCCTCCTCACCATTCCCCCCAGGAAGGCCATGTCCCAGTTTTCTG
TCCACCCCTCCTGTTCCTCTGCACTATGTCTCTGATTTTCCCTGCCAGGGAAGCTAACCCAGAGCACGCACCTGTGCTCATGAGTGTTTC
CGCAGGATAATTCGTTCTGAGCATGATACCACAGTGTGGATTGTCTGTCTGTAAGGAGATGCCATCTACTAACCAATTTGTATTGTGTTT

>In-frame_ENST00000330266_ENST00000405592_TCGA-HU-A4GN-01A_THADA_chr2_43655239_-_MTA3_chr2_42931337_length(amino acids)=1314AA_start in transcript=0_stop in transcript=3944
MSSCRSLCCGDISQSAVLFLCQGTLAMLDWQNGSMGRSGEALLLDTAHVLFTLSSQIKEPTLEMFLSRILASWTNSAIQVLESSSPSLTD
SLNGNSSIVGRLLEYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVEGADFVPDPFFVELTESLLRLEWHIKGKYTCLGCLVECIGVEHI
LAIDKTIPSQILEVMGDQSLVPYASDLLETMFRNHKSHLKSQTAESSWIDQWHETWVSPLLFILCEGNLDQKSYVIDYYLPKLLSYSPES
LQYMVKILQTSIDAKTGQEQSFPSLGSCNSRGALGALMACLRIARAHGHLQSATDTWENLVSDARIKQGLIHQHCQVRIDTLGLLCESNR
STEIVSMEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKLEQSKSKREPENELTKQHPSVSLQQYKNFMSSICNSLF
EALFPGSSYSTRFSALTILGSIAEVFHVPEGRIYTVYQLSHDIDVGRFQTLMECFTSTFEDVKILAFDLLMKLSKTAVHFQDSGKLQGLF
QAALELSTSTKPYDCVTASYLLNFLIWQDALPSSLSAYLTQQVACDNGDRPAAVVERNTLMVIKCLMENLEEEVSQAENSLLQAAAAFPM
YGRVHCITGALQKLSLNSLQLVSEWRPVVEKLLLMSYRLSTVVSPVIQSSSPEGLIPMDTDSESASRLQMILNEIQPRDTNDYFNQAKIL
KEHDSFDMKDLNASVVNIDTSTEIKGKEVKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPMQPVPESSDGLLTVEQVKEIGDYFKQHL
LQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKE
LISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWAVRNSSTLLFSALITRIFGVKRAKDEHSKTNRM
TGREFFSRFPELYPFLLKQLETVANTVDSDMGEPNRHPSMFLLLLVLERLYASPMDGTSSALSMGPFVPFIMSKPNPNQISTSNGKPGAV
NGAVGTTFQPQNPLLGRACESCYATQSHQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEKLSPSPTTEDPRVRSHVSRQAMQGM
PVRNTGSPKSAVKTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVAINYAAIRAEYADRHAELSGSPLKSKSTRKPLACIIGYLEIH

--------------------------------------------------------------
>In-frame_ENST00000330266_ENST00000406652_TCGA-HU-A4GN-01A_THADA_chr2_43655239_-_MTA3_chr2_42931337_length(transcript)=7493nt_BP=3188nt
ATGAGCAGCTGCAGGAGCCTCTGTTGTGGTGACATCTCTCAGTCAGCTGTCTTATTCCTCTGTCAGGGGACACTTGCCATGTTGGACTGG
CAGAACGGAAGCATGGGTCGGAGTGGGGAGGCCCTGCTCTTGGATACTGCACATGTTTTGTTCACCTTGAGTTCACAGATTAAAGAGCCA
ACGCTGGAAATGTTTCTGTCTAGAATCTTAGCATCCTGGACTAATTCAGCCATACAAGTCCTTGAATCAAGTTCCCCGAGCCTAACGGAC
AGCCTGAATGGGAATTCAAGTATAGTTGGGAGACTTTTGGAATATGTCTATACCCATTGGGAACATCCATTGGATGCTCTGAGACACCAA
ACCAAAATCATGTTCAAAAACCTTCTCCAAATGCACCGGCTCACTGTGGAAGGTGCAGATTTCGTCCCTGATCCTTTCTTTGTGGAATTG
ACTGAGAGTCTTTTACGATTGGAATGGCATATTAAAGGAAAGTACACGTGCCTTGGTTGTTTGGTAGAGTGCATAGGAGTTGAACATATT
TTGGCTATAGATAAAACTATTCCATCTCAAATCTTAGAGGTGATGGGAGACCAGTCATTGGTACCTTATGCAAGTGACCTCTTGGAAACC
ATGTTTAGAAATCATAAGAGTCATTTGAAATCCCAGACTGCTGAGAGTTCTTGGATTGACCAGTGGCATGAGACTTGGGTTTCTCCTCTC
CTTTTTATATTGTGTGAAGGAAACTTGGATCAAAAATCTTACGTGATTGATTATTACTTGCCAAAATTATTAAGTTACAGCCCTGAAAGC
TTACAGTACATGGTAAAGATTCTTCAGACTTCTATTGATGCTAAAACTGGACAAGAGCAATCTTTCCCATCCTTAGGGTCTTGTAATAGC
AGGGGGGCTCTGGGAGCTTTGATGGCATGTCTGCGAATAGCTAGAGCTCATGGACATCTTCAGTCTGCAACTGATACCTGGGAGAACCTC
GTGTCTGATGCAAGAATAAAGCAAGGCTTAATTCATCAGCATTGCCAAGTAAGGATAGATACATTAGGCTTGCTTTGTGAAAGTAATCGG
AGCACAGAAATTGTTTCCATGGAAGAAATGCAGTGGATTCAGTTCTTTATTACATACAATCTTAACAGCCAGTCTCCAGGAGTGCGGCAA
CAGATCTGTTCTCTTCTTAAAAAGTTGTTTTGTAGGATACAGGAAAGTTCTCAGGTACTTTATAAATTGGAGCAGAGTAAATCCAAACGT
GAACCAGAGAATGAGTTAACCAAACAGCACCCTTCTGTTTCTTTACAGCAGTATAAGAATTTCATGTCATCCATTTGTAACAGTCTTTTT
GAAGCATTGTTTCCTGGATCTTCCTACTCGACTAGATTTTCAGCTTTAACCATTTTAGGTTCAATAGCTGAAGTTTTTCATGTCCCAGAA
GGCAGAATTTATACAGTATATCAGCTGAGTCATGATATTGATGTTGGTCGTTTCCAAACACTAATGGAATGTTTTACCAGCACTTTTGAA
GACGTGAAAATTTTAGCATTTGATCTTCTGATGAAGTTATCAAAAACAGCTGTACATTTTCAGGATTCGGGGAAACTGCAAGGCTTATTT
CAGGCAGCATTGGAGCTCAGCACAAGCACCAAACCATACGACTGTGTGACAGCTTCCTACCTGCTGAACTTCTTAATCTGGCAGGATGCT
CTACCGTCATCCTTGTCTGCCTACTTAACTCAGCAAGTTGCATGTGATAATGGAGATAGGCCTGCTGCTGTGGTGGAAAGGAACACATTA
ATGGTTATCAAATGCTTGATGGAAAATCTTGAGGAAGAAGTATCTCAGGCTGAAAATTCTCTGCTTCAGGCAGCAGCAGCATTTCCAATG
TATGGGCGAGTCCACTGTATAACAGGAGCTTTGCAGAAGTTATCTCTAAACAGCCTGCAGTTGGTGAGCGAGTGGAGACCTGTGGTAGAG
AAGCTCCTTTTGATGTCCTACAGGCTTTCCACTGTGGTGTCTCCAGTCATTCAGAGCTCATCCCCTGAAGGCCTCATCCCAATGGACACT
GATTCAGAGTCAGCAAGCCGCTTACAGATGATTCTGAATGAGATTCAGCCTCGAGATACTAATGATTATTTTAACCAAGCCAAAATATTG
AAAGAACATGATAGCTTTGATATGAAGGACTTGAATGCTAGTGTGGTGAATATTGATACTTCTACAGAAATCAAAGGTAAAGAAGTAAAA
ACATGTGATGTAACTGCGCAGATGGTGCTGGTATGTTGTTGGAGAAGTATGAAGGAAGTTGCTTTACTTTTAGGCATGTTGTGCCAGCTT
CTGCCCATGCAGCCTGTGCCAGAATCTTCTGATGGATTATTGACGGTGGAGCAGGTAAAAGAAATAGGAGATTACTTTAAACAACACCTT
TTGCAGTCCAGGCACAGAGGAGCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAAACAGGTGCCCAAATGTGAGT
CTGCAAAAGCTGCCAGAACAGTGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTAAACTCTGTGCTACAAGGCGC
AGTGCTGGAATTCCTTTCTACATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGTTGAAAATAACAATGAAAGAG
TTAATCTCTTTGGCTGGGCCTACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCCTTAGAGCATTGTTCAGAGAT
ACGCGCCTGGGAGAAAATATTATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACATCACCGGTCTGGGCAGTGCGA
AATTCATCCACACTTCTCTTTAGTGCCTTGATCACAAGAATTTTTGGAGTTAAAAGGGCAAAGGATGAACATTCCAAAACAAATAGAATG
ACAGGGAGAGAGTTTTTCTCTCGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTGTAGCCAATACAGTAGACAGTGAT
ATGGGAGAACCAAATCGTCATCCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTTCCCCGATGGATGGTACTTCTTCT
GCTCTCAGCATGGGACCTTTTGTTCCCTTCATTATGAGCAAACCAAATCCCAACCAAATATCCACTAGTAATGGGAAGCCTGGTGCTGTG
AATGGAGCTGTGGGGACCACGTTCCAGCCTCAGAATCCTCTCTTAGGGAGAGCCTGTGAGAGCTGCTATGCTACACAGTCTCACCAGTGG
TATTCTTGGGGCCCACCTAATATGCAGTGTAGATTATGTGCAATTTGTTGGCTTTATTGGAAAAAATATGGAGGCTTGAAAATGCCCACC
CAGTCAGAAGAAGAGAAGTTATCTCCTAGCCCAACTACAGAGGACCCTCGTGTTAGAAGTCACGTGTCCCGCCAGGCCATGCAGGGAATG
CCAGTCCGAAACACTGGGAGTCCAAAGTCTGCAGTGAAGACCCGCCAAGCTTTCTTCCTTCATACTACATATTTCACAAAATTTGCTCGT
CAGGTCTGCAAAAATACCCTCCGGCTGCGGCAGGCAGCAAGACGGCCGTTTGTTGCTATTAATTATGCTGCCATTAGGGCAGAATATGCA
GACAGACATGCTGAACTATCTGGAAGTCCACTGAAAAGCAAAAGCACTAGGAAGCCTTTGGCATGTATCATTGGGTATTTAGAGATCCAT
CCTGCAAAGAAACCTAATGTAATTCGATCTACACCAAGCCTGCAAACCCCAACTACCAAGCGGATGCTAACAACTCCAAATCACACATCT
CTGAGCATTCTGGGGAAAAGAAACTACAGTCATCACAATGGTCTGGATGAACTCACGTGCTGTGTGTCAGACTGAGCTTTCCCTGATTCA
TTCTACAATCCAAGACTTGCTGCACTGTCCTGCTGATGTTCACAGCCGTGCCTGGGAAGAAGGCAGCCCCACTCCCAGTACATTTCAGTG
GGAGACCTCTGCGTGCATCCATGGAGACGCAATGGGGCGGGGAAGGAACTGTGGGAGTGCACGTTCCAAATCCTGTGTCTCCACGTGTGG
ATCAGCAGCACCTCGCTTTCTTGTCAGAGACCTCGCTGTTACGGAGCGAGACCTGCTGAGAATTGAGGGGCTGAGGGAACCCCTCCACCT
CCTCCCTTCTGCAGCGCCCTGCGCCCCACCCAGCAACAGCGGCCACTTGGCAGTGGGGCTGCTGCAAGCTCAGAGCCGCTGCCACCCTGC
ATGTGTCCGCTCAGCTCGGTCTTATGCTGTATAGTTACTAAATATGTACAGGAGGGCCATGGCATCTTTCTGAATGGATTTTTCTTAAGA
AATGCGCCAGTGTTTATGAGGTTCAAGGTATTTCCCTGTCCTTGCTGTTACCGTCACTCAGCTTTTTCTCGATAGGCTTCATCCTTGTTT
TTTTGAAATGGGGGAATTTGCTGTTTACCCTCTGCATTCCTATATGTGACCCTCCCTCCTACTCCTCCAAGGAACAGAATTACCGAGGTT
CTGACAAAAGATAAGCCTGTAAACTCATCATCTGTGTTTTGTGGTTGGAGAGAAACTGGTGTTCTGCCCGGCTCTGCTTGGTCACAGACA
GCTCCAGCAAGAGCAGTTGTTAAAAGTGCCAAGCGTGTGTATCACTGTGACAAGCCGTTTGCTTACTGCCCTGTTCCCTTGCAGCCAAAC
CAGCTGATGAAGAACTGCTGCCAGGTGGGTCCTACAGCAGGTCACAAATGACCTAGTTTCATTTTAAGCAGACAGACTCTGTTTGGCCTA
GAGGTGTGGAGTGAGAGAACTGTGTTTGTGGGTATGAGTCTGTGTGGCCAACCCCATGACCCCCACCCCTCCAGCCCAACATCTTGTGAG
CACATGTGACCTAGGCCCCGGGGGACCTGCCTGCTCCTTTGGCTTGGGCTCTTCGTGTTTCCCACCTGCCCTCGGCACGAGCCCTTGGTG
GCATCACAGTTGGCCACTCAGCTGTGCTGAGTAGCTGTGCTACTTGTGCTGGCAGCTGCAAGGATAGGAATAGCTCAGCGCCCGATGAGC
TCCCTGAGCAGATGTGAGGCTGGCAACTCCCCTGCCCTCTGTTTGCAGGCACAGGGTCACAGTCCCAAGAAAGACAACTGGAGTCTGATC
TCCCAGCCATCTCTGGGGTTACTAGGAGGCAGCTGGATGGCAGATACGAGAGGCCCAAATAGCCAAGCTGTTGCAAGACAGAGTGGCTAC
AATTGAATTGACACCCTGGGAAGCACGAGGTAACTTGGTAAGGATAATGATGCTGTAGATGTCTGTGTCCTCGGAGGCTGAGCTCCGCTT
GGCAGAGAGAGCGTGCTGTGTGAGGTGGAGGGCGGTTTTGCAGACATCTCAGCTTCTTTTCTGAGGAGGAGTTGGTTCTCATCTTAGGCT
TCTGCAAGGGCGAGCATGGGATGTCTCCACCACCACCCACTCTTGGAGCTGTGCTGGGTCTTGGCTTGGGGCGCTGAGGGTGGGGCCTGT
GTCAGAAGCATTTGGTGAGAGGGGTGGAGGTGGCAGGCAGGGGTTCTCCTCAGGGTTCCCACTGAGGGGTCCCTTCAGCAAAGACCTGGG
AGGAGGTGCCGCATCACGTGGATGTTTCTTCCCTAAAGAAAAAGACACAGGAAAGCTGTCTGTCTGTACCCTGCTCTGGATTTATTGTCG
TACTTGGACCCAGAAGGGGAAATGATTCCCTCACCCTTTCACTTTCTCTCTGAACCCCTACTAAGTGGTGACTGCAGATTCTGGAAACAA
TTAGCTGCCCGTGACTCAGCTGCCAGCTTCATTTTCTCTGCCTTTTGGGAGAGGCCCTCTCACCCAGGCCCAAGAGATTTGGAGACAGGA
GTCAGGCCAGGTCTGAAGCAGGAGAAGGGAGGCCCCTCCTATCTACCCAGTTGACATTTGGCTTTGGGAAAAGCGCAGCTTGTTCGAGCC
ACGTGTGCCAAGCAGGCTTTTCCTTCCTCTTGTAAGTAAAGCTCGTGGTTCTGTAGTCCAGTCATCCTAGGAGGGTGATGTTGACTGAGA
CTTCACGCTCTCCCTTTGTCTCTGGAAACTGCCCCCTCGTTCTGACAGAATCCCCCAGGCAATGGAGGAAGGGTGCCGAGGCGCCTCTAG
TCTGTGCCTTTGCCGTTGGAAGCATTTGGTGCTGAGAGGGTTTCCCAGCCACCCGCTCCCTTTCTGGGGCCATGGTGTCCCTGCTGTGTG
TCAGTGGCATGTCACTGTGGTTCAGTGAGCACATGGGTGGACGTGCAGAGACTGTCTGCGCAGCCCCCAGCAGACATGCCCCTGGGGTGA
GGACACAGGCTCTGCAGGCTATCTCCCCCTCTGGCTCAGTCATCGCCTGCCCACCCTTCACTTCTTAAAGGTGCGCAAGAGAGGAGGGCC
GACTGGAGGGTGTCGCCGGAAGGTTTCAGCCTGCCCTTCACAATTCCCCTTGTGCACAGCCCAGTTTCCATCTCTCAGGGCCCACCCAGG
AAAATGGATTTCAAGTGGGGGTTTTCATCCAGAGATTTGTTTAACACAAAACAAGAAAAGCTGAGAGGCAAAACAGGGGAGTGAGGGGCA
ACCCAGAGGTGGGGAACAACAACAGCAAGCCGCCCCCATCCTGAGACTGGCTGGGCACCAGGGGAGGACGCGTCACCAGAGCCTGGGGCC
AAGGCCACTGGGGGACCTGCCACACTGTGGACCTGTCTGGTGGGGGCTGGAGCCTCGAGAAGCCATGATTCTTGTCAGAAACATTTCCCC
AGGCAGAGAGAGGGGGCCCCAGCCTCTCCCCTCCTCTTGGCCTCCAGAGTCCTGCAGGTGCCTCACAGTAGTGAAACCCAGTTGGAAGCA
GCTGCCCTGGGAGCCTGGGACAGGCGACCCACCGGGTCAGTCCCCTGCCACTCAGAGCAGAGCAGGGGGCTGAGGGCAAGCAGGTGGGGC
TGTGCGTGGCCTCAGTGCACTCGGTGTCATGTCTGAGCCTGGTGTTTATGCCCCACTGCTGTCCTAAGTCCCTGGCGAGGGGAGGTGGAG
GAGCTGCCCCGTGGGTGTTTGGAGATTCTGTTTTACTCTGCCTAGAGAGGAAACGGCTTTGGGGAGGGAGGGGGAAGCCTTTATTCTTTA
CTGTTGTCCCTGTTTTCCTTTGGGGGAATTTACTCAGTTAGCAGCCCCTCCTCACCATTCCCCCCAGGAAGGCCATGTCCCAGTTTTCTG
TCCACCCCTCCTGTTCCTCTGCACTATGTCTCTGATTTTCCCTGCCAGGGAAGCTAACCCAGAGCACGCACCTGTGCTCATGAGTGTTTC
CGCAGGATAATTCGTTCTGAGCATGATACCACAGTGTGGATTGTCTGTCTGTAAGGAGATGCCATCTACTAACCAATTTGTATTGTGTTT

>In-frame_ENST00000330266_ENST00000406652_TCGA-HU-A4GN-01A_THADA_chr2_43655239_-_MTA3_chr2_42931337_length(amino acids)=1314AA_start in transcript=0_stop in transcript=3944
MSSCRSLCCGDISQSAVLFLCQGTLAMLDWQNGSMGRSGEALLLDTAHVLFTLSSQIKEPTLEMFLSRILASWTNSAIQVLESSSPSLTD
SLNGNSSIVGRLLEYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVEGADFVPDPFFVELTESLLRLEWHIKGKYTCLGCLVECIGVEHI
LAIDKTIPSQILEVMGDQSLVPYASDLLETMFRNHKSHLKSQTAESSWIDQWHETWVSPLLFILCEGNLDQKSYVIDYYLPKLLSYSPES
LQYMVKILQTSIDAKTGQEQSFPSLGSCNSRGALGALMACLRIARAHGHLQSATDTWENLVSDARIKQGLIHQHCQVRIDTLGLLCESNR
STEIVSMEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKLEQSKSKREPENELTKQHPSVSLQQYKNFMSSICNSLF
EALFPGSSYSTRFSALTILGSIAEVFHVPEGRIYTVYQLSHDIDVGRFQTLMECFTSTFEDVKILAFDLLMKLSKTAVHFQDSGKLQGLF
QAALELSTSTKPYDCVTASYLLNFLIWQDALPSSLSAYLTQQVACDNGDRPAAVVERNTLMVIKCLMENLEEEVSQAENSLLQAAAAFPM
YGRVHCITGALQKLSLNSLQLVSEWRPVVEKLLLMSYRLSTVVSPVIQSSSPEGLIPMDTDSESASRLQMILNEIQPRDTNDYFNQAKIL
KEHDSFDMKDLNASVVNIDTSTEIKGKEVKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPMQPVPESSDGLLTVEQVKEIGDYFKQHL
LQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKE
LISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWAVRNSSTLLFSALITRIFGVKRAKDEHSKTNRM
TGREFFSRFPELYPFLLKQLETVANTVDSDMGEPNRHPSMFLLLLVLERLYASPMDGTSSALSMGPFVPFIMSKPNPNQISTSNGKPGAV
NGAVGTTFQPQNPLLGRACESCYATQSHQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEKLSPSPTTEDPRVRSHVSRQAMQGM
PVRNTGSPKSAVKTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVAINYAAIRAEYADRHAELSGSPLKSKSTRKPLACIIGYLEIH

--------------------------------------------------------------
>In-frame_ENST00000330266_ENST00000407270_TCGA-HU-A4GN-01A_THADA_chr2_43655239_-_MTA3_chr2_42931337_length(transcript)=4136nt_BP=3188nt
ATGAGCAGCTGCAGGAGCCTCTGTTGTGGTGACATCTCTCAGTCAGCTGTCTTATTCCTCTGTCAGGGGACACTTGCCATGTTGGACTGG
CAGAACGGAAGCATGGGTCGGAGTGGGGAGGCCCTGCTCTTGGATACTGCACATGTTTTGTTCACCTTGAGTTCACAGATTAAAGAGCCA
ACGCTGGAAATGTTTCTGTCTAGAATCTTAGCATCCTGGACTAATTCAGCCATACAAGTCCTTGAATCAAGTTCCCCGAGCCTAACGGAC
AGCCTGAATGGGAATTCAAGTATAGTTGGGAGACTTTTGGAATATGTCTATACCCATTGGGAACATCCATTGGATGCTCTGAGACACCAA
ACCAAAATCATGTTCAAAAACCTTCTCCAAATGCACCGGCTCACTGTGGAAGGTGCAGATTTCGTCCCTGATCCTTTCTTTGTGGAATTG
ACTGAGAGTCTTTTACGATTGGAATGGCATATTAAAGGAAAGTACACGTGCCTTGGTTGTTTGGTAGAGTGCATAGGAGTTGAACATATT
TTGGCTATAGATAAAACTATTCCATCTCAAATCTTAGAGGTGATGGGAGACCAGTCATTGGTACCTTATGCAAGTGACCTCTTGGAAACC
ATGTTTAGAAATCATAAGAGTCATTTGAAATCCCAGACTGCTGAGAGTTCTTGGATTGACCAGTGGCATGAGACTTGGGTTTCTCCTCTC
CTTTTTATATTGTGTGAAGGAAACTTGGATCAAAAATCTTACGTGATTGATTATTACTTGCCAAAATTATTAAGTTACAGCCCTGAAAGC
TTACAGTACATGGTAAAGATTCTTCAGACTTCTATTGATGCTAAAACTGGACAAGAGCAATCTTTCCCATCCTTAGGGTCTTGTAATAGC
AGGGGGGCTCTGGGAGCTTTGATGGCATGTCTGCGAATAGCTAGAGCTCATGGACATCTTCAGTCTGCAACTGATACCTGGGAGAACCTC
GTGTCTGATGCAAGAATAAAGCAAGGCTTAATTCATCAGCATTGCCAAGTAAGGATAGATACATTAGGCTTGCTTTGTGAAAGTAATCGG
AGCACAGAAATTGTTTCCATGGAAGAAATGCAGTGGATTCAGTTCTTTATTACATACAATCTTAACAGCCAGTCTCCAGGAGTGCGGCAA
CAGATCTGTTCTCTTCTTAAAAAGTTGTTTTGTAGGATACAGGAAAGTTCTCAGGTACTTTATAAATTGGAGCAGAGTAAATCCAAACGT
GAACCAGAGAATGAGTTAACCAAACAGCACCCTTCTGTTTCTTTACAGCAGTATAAGAATTTCATGTCATCCATTTGTAACAGTCTTTTT
GAAGCATTGTTTCCTGGATCTTCCTACTCGACTAGATTTTCAGCTTTAACCATTTTAGGTTCAATAGCTGAAGTTTTTCATGTCCCAGAA
GGCAGAATTTATACAGTATATCAGCTGAGTCATGATATTGATGTTGGTCGTTTCCAAACACTAATGGAATGTTTTACCAGCACTTTTGAA
GACGTGAAAATTTTAGCATTTGATCTTCTGATGAAGTTATCAAAAACAGCTGTACATTTTCAGGATTCGGGGAAACTGCAAGGCTTATTT
CAGGCAGCATTGGAGCTCAGCACAAGCACCAAACCATACGACTGTGTGACAGCTTCCTACCTGCTGAACTTCTTAATCTGGCAGGATGCT
CTACCGTCATCCTTGTCTGCCTACTTAACTCAGCAAGTTGCATGTGATAATGGAGATAGGCCTGCTGCTGTGGTGGAAAGGAACACATTA
ATGGTTATCAAATGCTTGATGGAAAATCTTGAGGAAGAAGTATCTCAGGCTGAAAATTCTCTGCTTCAGGCAGCAGCAGCATTTCCAATG
TATGGGCGAGTCCACTGTATAACAGGAGCTTTGCAGAAGTTATCTCTAAACAGCCTGCAGTTGGTGAGCGAGTGGAGACCTGTGGTAGAG
AAGCTCCTTTTGATGTCCTACAGGCTTTCCACTGTGGTGTCTCCAGTCATTCAGAGCTCATCCCCTGAAGGCCTCATCCCAATGGACACT
GATTCAGAGTCAGCAAGCCGCTTACAGATGATTCTGAATGAGATTCAGCCTCGAGATACTAATGATTATTTTAACCAAGCCAAAATATTG
AAAGAACATGATAGCTTTGATATGAAGGACTTGAATGCTAGTGTGGTGAATATTGATACTTCTACAGAAATCAAAGGTAAAGAAGTAAAA
ACATGTGATGTAACTGCGCAGATGGTGCTGGTATGTTGTTGGAGAAGTATGAAGGAAGTTGCTTTACTTTTAGGCATGTTGTGCCAGCTT
CTGCCCATGCAGCCTGTGCCAGAATCTTCTGATGGATTATTGACGGTGGAGCAGGTAAAAGAAATAGGAGATTACTTTAAACAACACCTT
TTGCAGTCCAGGCACAGAGGAGCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAAACAGGTGCCCAAATGTGAGT
CTGCAAAAGCTGCCAGAACAGTGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTAAACTCTGTGCTACAAGGCGC
AGTGCTGGAATTCCTTTCTACATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGTTGAAAATAACAATGAAAGAG
TTAATCTCTTTGGCTGGGCCTACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCCTTAGAGCATTGTTCAGAGAT
ACGCGCCTGGGAGAAAATATTATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACATCACCGGTCTGGGCAGTGCGA
AATTCATCCACACTTCTCTTTAGTGCCTTGATCACAAGAATTTTTGGAGTTAAAAGGGCAAAGGATGAACATTCCAAAACAAATAGAATG
ACAGGGAGAGAGTTTTTCTCTCGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTGTAGCCAATACAGTAGACAGTGAT
ATGGGAGAACCAAATCGTCATCCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTTCCCCGATGGATGGTACTTCTTCT
GCTCTCAGCATGGGACCTTTTGTTCCCTTCATTATGAGCAGCAAACCAAATCCCAACCAAATATCCACTAGTAATGGGAAGCCTGGTGCT
GTGAATGGAGCTGTGGGGACCACGTTCCAGCCTCAGAATCCTCTCTTAGGGAGAGCCTGTGAGAGCTGCTATGCTACACAGTCTCACCAG
TGGTATTCTTGGGGCCCACCTAATATGCAGTGTAGATTATGTGCAATTTGTTGGCTTTATTGGAAAAAATATGGAGGCTTGAAAATGCCC
ACCCAGTCAGAAGAAGAGAAGTTATCTCCTAGCCCAACTACAGAGGACCCTCGTGTTAGAAGTCACGTGTCCCGCCAGGCCATGCAGGGA
ATGCCAGTCCGAAACACTGGGAGTCCAAAGTCTGCAGTGAAGACCCGCCAAGCTTTCTTCCTTCATACTACATATTTCACAAAATTTGCT
CGTCAGGTCTGCAAAAATACCCTCCGGCTGCGGCAGGCAGCAAGACGGCCGTTTGTTGCTATTAATTATGCTGCCATTAGGGCAGAATGT
AAGATGCTTTTAAATTCTTAACCTTATATGTTGTGCTTCTGACCATTTTCTCTTTTCCTCTCTTTCCTTTTTTTTTTGTTTGTTTGTTTG
CAATAAACATAAGTTCTTGTGTACAGCCTTTTATTTGGTTTATTTTTTAACATTGTTTTTGTGTGCTGCCATTTGTATCATGCCAACCTG
GAAAAAAAAAATCAAAACATTGAAACTTCTGTACTCTTTACCAGAGAGTAGTGCTTAGCAAAAGATTGGTGGGAGGTGATCCTATTCCAT
GGGGTTTTGTGATGGAATTGCCTGCAGAGCCCTTATTGAAGCACTTTTACCTTTTAGGTAGTGCCACAATGTAACCCCTAAGGATGCTGT

>In-frame_ENST00000330266_ENST00000407270_TCGA-HU-A4GN-01A_THADA_chr2_43655239_-_MTA3_chr2_42931337_length(amino acids)=1236AA_start in transcript=0_stop in transcript=3710
MSSCRSLCCGDISQSAVLFLCQGTLAMLDWQNGSMGRSGEALLLDTAHVLFTLSSQIKEPTLEMFLSRILASWTNSAIQVLESSSPSLTD
SLNGNSSIVGRLLEYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVEGADFVPDPFFVELTESLLRLEWHIKGKYTCLGCLVECIGVEHI
LAIDKTIPSQILEVMGDQSLVPYASDLLETMFRNHKSHLKSQTAESSWIDQWHETWVSPLLFILCEGNLDQKSYVIDYYLPKLLSYSPES
LQYMVKILQTSIDAKTGQEQSFPSLGSCNSRGALGALMACLRIARAHGHLQSATDTWENLVSDARIKQGLIHQHCQVRIDTLGLLCESNR
STEIVSMEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKLEQSKSKREPENELTKQHPSVSLQQYKNFMSSICNSLF
EALFPGSSYSTRFSALTILGSIAEVFHVPEGRIYTVYQLSHDIDVGRFQTLMECFTSTFEDVKILAFDLLMKLSKTAVHFQDSGKLQGLF
QAALELSTSTKPYDCVTASYLLNFLIWQDALPSSLSAYLTQQVACDNGDRPAAVVERNTLMVIKCLMENLEEEVSQAENSLLQAAAAFPM
YGRVHCITGALQKLSLNSLQLVSEWRPVVEKLLLMSYRLSTVVSPVIQSSSPEGLIPMDTDSESASRLQMILNEIQPRDTNDYFNQAKIL
KEHDSFDMKDLNASVVNIDTSTEIKGKEVKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPMQPVPESSDGLLTVEQVKEIGDYFKQHL
LQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKE
LISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWAVRNSSTLLFSALITRIFGVKRAKDEHSKTNRM
TGREFFSRFPELYPFLLKQLETVANTVDSDMGEPNRHPSMFLLLLVLERLYASPMDGTSSALSMGPFVPFIMSSKPNPNQISTSNGKPGA
VNGAVGTTFQPQNPLLGRACESCYATQSHQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEKLSPSPTTEDPRVRSHVSRQAMQG

--------------------------------------------------------------
>In-frame_ENST00000330266_ENST00000406911_TCGA-HU-A4GN-01A_THADA_chr2_43655239_-_MTA3_chr2_42931337_length(transcript)=4133nt_BP=3188nt
ATGAGCAGCTGCAGGAGCCTCTGTTGTGGTGACATCTCTCAGTCAGCTGTCTTATTCCTCTGTCAGGGGACACTTGCCATGTTGGACTGG
CAGAACGGAAGCATGGGTCGGAGTGGGGAGGCCCTGCTCTTGGATACTGCACATGTTTTGTTCACCTTGAGTTCACAGATTAAAGAGCCA
ACGCTGGAAATGTTTCTGTCTAGAATCTTAGCATCCTGGACTAATTCAGCCATACAAGTCCTTGAATCAAGTTCCCCGAGCCTAACGGAC
AGCCTGAATGGGAATTCAAGTATAGTTGGGAGACTTTTGGAATATGTCTATACCCATTGGGAACATCCATTGGATGCTCTGAGACACCAA
ACCAAAATCATGTTCAAAAACCTTCTCCAAATGCACCGGCTCACTGTGGAAGGTGCAGATTTCGTCCCTGATCCTTTCTTTGTGGAATTG
ACTGAGAGTCTTTTACGATTGGAATGGCATATTAAAGGAAAGTACACGTGCCTTGGTTGTTTGGTAGAGTGCATAGGAGTTGAACATATT
TTGGCTATAGATAAAACTATTCCATCTCAAATCTTAGAGGTGATGGGAGACCAGTCATTGGTACCTTATGCAAGTGACCTCTTGGAAACC
ATGTTTAGAAATCATAAGAGTCATTTGAAATCCCAGACTGCTGAGAGTTCTTGGATTGACCAGTGGCATGAGACTTGGGTTTCTCCTCTC
CTTTTTATATTGTGTGAAGGAAACTTGGATCAAAAATCTTACGTGATTGATTATTACTTGCCAAAATTATTAAGTTACAGCCCTGAAAGC
TTACAGTACATGGTAAAGATTCTTCAGACTTCTATTGATGCTAAAACTGGACAAGAGCAATCTTTCCCATCCTTAGGGTCTTGTAATAGC
AGGGGGGCTCTGGGAGCTTTGATGGCATGTCTGCGAATAGCTAGAGCTCATGGACATCTTCAGTCTGCAACTGATACCTGGGAGAACCTC
GTGTCTGATGCAAGAATAAAGCAAGGCTTAATTCATCAGCATTGCCAAGTAAGGATAGATACATTAGGCTTGCTTTGTGAAAGTAATCGG
AGCACAGAAATTGTTTCCATGGAAGAAATGCAGTGGATTCAGTTCTTTATTACATACAATCTTAACAGCCAGTCTCCAGGAGTGCGGCAA
CAGATCTGTTCTCTTCTTAAAAAGTTGTTTTGTAGGATACAGGAAAGTTCTCAGGTACTTTATAAATTGGAGCAGAGTAAATCCAAACGT
GAACCAGAGAATGAGTTAACCAAACAGCACCCTTCTGTTTCTTTACAGCAGTATAAGAATTTCATGTCATCCATTTGTAACAGTCTTTTT
GAAGCATTGTTTCCTGGATCTTCCTACTCGACTAGATTTTCAGCTTTAACCATTTTAGGTTCAATAGCTGAAGTTTTTCATGTCCCAGAA
GGCAGAATTTATACAGTATATCAGCTGAGTCATGATATTGATGTTGGTCGTTTCCAAACACTAATGGAATGTTTTACCAGCACTTTTGAA
GACGTGAAAATTTTAGCATTTGATCTTCTGATGAAGTTATCAAAAACAGCTGTACATTTTCAGGATTCGGGGAAACTGCAAGGCTTATTT
CAGGCAGCATTGGAGCTCAGCACAAGCACCAAACCATACGACTGTGTGACAGCTTCCTACCTGCTGAACTTCTTAATCTGGCAGGATGCT
CTACCGTCATCCTTGTCTGCCTACTTAACTCAGCAAGTTGCATGTGATAATGGAGATAGGCCTGCTGCTGTGGTGGAAAGGAACACATTA
ATGGTTATCAAATGCTTGATGGAAAATCTTGAGGAAGAAGTATCTCAGGCTGAAAATTCTCTGCTTCAGGCAGCAGCAGCATTTCCAATG
TATGGGCGAGTCCACTGTATAACAGGAGCTTTGCAGAAGTTATCTCTAAACAGCCTGCAGTTGGTGAGCGAGTGGAGACCTGTGGTAGAG
AAGCTCCTTTTGATGTCCTACAGGCTTTCCACTGTGGTGTCTCCAGTCATTCAGAGCTCATCCCCTGAAGGCCTCATCCCAATGGACACT
GATTCAGAGTCAGCAAGCCGCTTACAGATGATTCTGAATGAGATTCAGCCTCGAGATACTAATGATTATTTTAACCAAGCCAAAATATTG
AAAGAACATGATAGCTTTGATATGAAGGACTTGAATGCTAGTGTGGTGAATATTGATACTTCTACAGAAATCAAAGGTAAAGAAGTAAAA
ACATGTGATGTAACTGCGCAGATGGTGCTGGTATGTTGTTGGAGAAGTATGAAGGAAGTTGCTTTACTTTTAGGCATGTTGTGCCAGCTT
CTGCCCATGCAGCCTGTGCCAGAATCTTCTGATGGATTATTGACGGTGGAGCAGGTAAAAGAAATAGGAGATTACTTTAAACAACACCTT
TTGCAGTCCAGGCACAGAGGAGCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAAACAGGTGCCCAAATGTGAGT
CTGCAAAAGCTGCCAGAACAGTGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTAAACTCTGTGCTACAAGGCGC
AGTGCTGGAATTCCTTTCTACATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGTTGAAAATAACAATGAAAGAG
TTAATCTCTTTGGCTGGGCCTACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCCTTAGAGCATTGTTCAGAGAT
ACGCGCCTGGGAGAAAATATTATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACATCACCGGTCTGGGCAGTGCGA
AATTCATCCACACTTCTCTTTAGTGCCTTGATCACAAGAATTTTTGGAGTTAAAAGGGCAAAGGATGAACATTCCAAAACAAATAGAATG
ACAGGGAGAGAGTTTTTCTCTCGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTGTAGCCAATACAGTAGACAGTGAT
ATGGGAGAACCAAATCGTCATCCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTTCCCCGATGGATGGTACTTCTTCT
GCTCTCAGCATGGGACCTTTTGTTCCCTTCATTATGAGCAAACCAAATCCCAACCAAATATCCACTAGTAATGGGAAGCCTGGTGCTGTG
AATGGAGCTGTGGGGACCACGTTCCAGCCTCAGAATCCTCTCTTAGGGAGAGCCTGTGAGAGCTGCTATGCTACACAGTCTCACCAGTGG
TATTCTTGGGGCCCACCTAATATGCAGTGTAGATTATGTGCAATTTGTTGGCTTTATTGGAAAAAATATGGAGGCTTGAAAATGCCCACC
CAGTCAGAAGAAGAGAAGTTATCTCCTAGCCCAACTACAGAGGACCCTCGTGTTAGAAGTCACGTGTCCCGCCAGGCCATGCAGGGAATG
CCAGTCCGAAACACTGGGAGTCCAAAGTCTGCAGTGAAGACCCGCCAAGCTTTCTTCCTTCATACTACATATTTCACAAAATTTGCTCGT
CAGGTCTGCAAAAATACCCTCCGGCTGCGGCAGGCAGCAAGACGGCCGTTTGTTGCTATTAATTATGCTGCCATTAGGGCAGAATGTAAG
ATGCTTTTAAATTCTTAACCTTATATGTTGTGCTTCTGACCATTTTCTCTTTTCCTCTCTTTCCTTTTTTTTTTGTTTGTTTGTTTGCAA
TAAACATAAGTTCTTGTGTACAGCCTTTTATTTGGTTTATTTTTTAACATTGTTTTTGTGTGCTGCCATTTGTATCATGCCAACCTGGAA
AAAAAAAATCAAAACATTGAAACTTCTGTACTCTTTACCAGAGAGTAGTGCTTAGCAAAAGATTGGTGGGAGGTGATCCTATTCCATGGG
GTTTTGTGATGGAATTGCCTGCAGAGCCCTTATTGAAGCACTTTTACCTTTTAGGTAGTGCCACAATGTAACCCCTAAGGATGCTGTTAT

>In-frame_ENST00000330266_ENST00000406911_TCGA-HU-A4GN-01A_THADA_chr2_43655239_-_MTA3_chr2_42931337_length(amino acids)=1235AA_start in transcript=0_stop in transcript=3707
MSSCRSLCCGDISQSAVLFLCQGTLAMLDWQNGSMGRSGEALLLDTAHVLFTLSSQIKEPTLEMFLSRILASWTNSAIQVLESSSPSLTD
SLNGNSSIVGRLLEYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVEGADFVPDPFFVELTESLLRLEWHIKGKYTCLGCLVECIGVEHI
LAIDKTIPSQILEVMGDQSLVPYASDLLETMFRNHKSHLKSQTAESSWIDQWHETWVSPLLFILCEGNLDQKSYVIDYYLPKLLSYSPES
LQYMVKILQTSIDAKTGQEQSFPSLGSCNSRGALGALMACLRIARAHGHLQSATDTWENLVSDARIKQGLIHQHCQVRIDTLGLLCESNR
STEIVSMEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKLEQSKSKREPENELTKQHPSVSLQQYKNFMSSICNSLF
EALFPGSSYSTRFSALTILGSIAEVFHVPEGRIYTVYQLSHDIDVGRFQTLMECFTSTFEDVKILAFDLLMKLSKTAVHFQDSGKLQGLF
QAALELSTSTKPYDCVTASYLLNFLIWQDALPSSLSAYLTQQVACDNGDRPAAVVERNTLMVIKCLMENLEEEVSQAENSLLQAAAAFPM
YGRVHCITGALQKLSLNSLQLVSEWRPVVEKLLLMSYRLSTVVSPVIQSSSPEGLIPMDTDSESASRLQMILNEIQPRDTNDYFNQAKIL
KEHDSFDMKDLNASVVNIDTSTEIKGKEVKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPMQPVPESSDGLLTVEQVKEIGDYFKQHL
LQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKE
LISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWAVRNSSTLLFSALITRIFGVKRAKDEHSKTNRM
TGREFFSRFPELYPFLLKQLETVANTVDSDMGEPNRHPSMFLLLLVLERLYASPMDGTSSALSMGPFVPFIMSKPNPNQISTSNGKPGAV
NGAVGTTFQPQNPLLGRACESCYATQSHQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEKLSPSPTTEDPRVRSHVSRQAMQGM

--------------------------------------------------------------
>In-frame_ENST00000330266_ENST00000405094_TCGA-HU-A4GN-01A_THADA_chr2_43655239_-_MTA3_chr2_42931337_length(transcript)=3948nt_BP=3188nt
ATGAGCAGCTGCAGGAGCCTCTGTTGTGGTGACATCTCTCAGTCAGCTGTCTTATTCCTCTGTCAGGGGACACTTGCCATGTTGGACTGG
CAGAACGGAAGCATGGGTCGGAGTGGGGAGGCCCTGCTCTTGGATACTGCACATGTTTTGTTCACCTTGAGTTCACAGATTAAAGAGCCA
ACGCTGGAAATGTTTCTGTCTAGAATCTTAGCATCCTGGACTAATTCAGCCATACAAGTCCTTGAATCAAGTTCCCCGAGCCTAACGGAC
AGCCTGAATGGGAATTCAAGTATAGTTGGGAGACTTTTGGAATATGTCTATACCCATTGGGAACATCCATTGGATGCTCTGAGACACCAA
ACCAAAATCATGTTCAAAAACCTTCTCCAAATGCACCGGCTCACTGTGGAAGGTGCAGATTTCGTCCCTGATCCTTTCTTTGTGGAATTG
ACTGAGAGTCTTTTACGATTGGAATGGCATATTAAAGGAAAGTACACGTGCCTTGGTTGTTTGGTAGAGTGCATAGGAGTTGAACATATT
TTGGCTATAGATAAAACTATTCCATCTCAAATCTTAGAGGTGATGGGAGACCAGTCATTGGTACCTTATGCAAGTGACCTCTTGGAAACC
ATGTTTAGAAATCATAAGAGTCATTTGAAATCCCAGACTGCTGAGAGTTCTTGGATTGACCAGTGGCATGAGACTTGGGTTTCTCCTCTC
CTTTTTATATTGTGTGAAGGAAACTTGGATCAAAAATCTTACGTGATTGATTATTACTTGCCAAAATTATTAAGTTACAGCCCTGAAAGC
TTACAGTACATGGTAAAGATTCTTCAGACTTCTATTGATGCTAAAACTGGACAAGAGCAATCTTTCCCATCCTTAGGGTCTTGTAATAGC
AGGGGGGCTCTGGGAGCTTTGATGGCATGTCTGCGAATAGCTAGAGCTCATGGACATCTTCAGTCTGCAACTGATACCTGGGAGAACCTC
GTGTCTGATGCAAGAATAAAGCAAGGCTTAATTCATCAGCATTGCCAAGTAAGGATAGATACATTAGGCTTGCTTTGTGAAAGTAATCGG
AGCACAGAAATTGTTTCCATGGAAGAAATGCAGTGGATTCAGTTCTTTATTACATACAATCTTAACAGCCAGTCTCCAGGAGTGCGGCAA
CAGATCTGTTCTCTTCTTAAAAAGTTGTTTTGTAGGATACAGGAAAGTTCTCAGGTACTTTATAAATTGGAGCAGAGTAAATCCAAACGT
GAACCAGAGAATGAGTTAACCAAACAGCACCCTTCTGTTTCTTTACAGCAGTATAAGAATTTCATGTCATCCATTTGTAACAGTCTTTTT
GAAGCATTGTTTCCTGGATCTTCCTACTCGACTAGATTTTCAGCTTTAACCATTTTAGGTTCAATAGCTGAAGTTTTTCATGTCCCAGAA
GGCAGAATTTATACAGTATATCAGCTGAGTCATGATATTGATGTTGGTCGTTTCCAAACACTAATGGAATGTTTTACCAGCACTTTTGAA
GACGTGAAAATTTTAGCATTTGATCTTCTGATGAAGTTATCAAAAACAGCTGTACATTTTCAGGATTCGGGGAAACTGCAAGGCTTATTT
CAGGCAGCATTGGAGCTCAGCACAAGCACCAAACCATACGACTGTGTGACAGCTTCCTACCTGCTGAACTTCTTAATCTGGCAGGATGCT
CTACCGTCATCCTTGTCTGCCTACTTAACTCAGCAAGTTGCATGTGATAATGGAGATAGGCCTGCTGCTGTGGTGGAAAGGAACACATTA
ATGGTTATCAAATGCTTGATGGAAAATCTTGAGGAAGAAGTATCTCAGGCTGAAAATTCTCTGCTTCAGGCAGCAGCAGCATTTCCAATG
TATGGGCGAGTCCACTGTATAACAGGAGCTTTGCAGAAGTTATCTCTAAACAGCCTGCAGTTGGTGAGCGAGTGGAGACCTGTGGTAGAG
AAGCTCCTTTTGATGTCCTACAGGCTTTCCACTGTGGTGTCTCCAGTCATTCAGAGCTCATCCCCTGAAGGCCTCATCCCAATGGACACT
GATTCAGAGTCAGCAAGCCGCTTACAGATGATTCTGAATGAGATTCAGCCTCGAGATACTAATGATTATTTTAACCAAGCCAAAATATTG
AAAGAACATGATAGCTTTGATATGAAGGACTTGAATGCTAGTGTGGTGAATATTGATACTTCTACAGAAATCAAAGGTAAAGAAGTAAAA
ACATGTGATGTAACTGCGCAGATGGTGCTGGTATGTTGTTGGAGAAGTATGAAGGAAGTTGCTTTACTTTTAGGCATGTTGTGCCAGCTT
CTGCCCATGCAGCCTGTGCCAGAATCTTCTGATGGATTATTGACGGTGGAGCAGGTAAAAGAAATAGGAGATTACTTTAAACAACACCTT
TTGCAGTCCAGGCACAGAGGAGCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAAACAGGTGCCCAAATGTGAGT
CTGCAAAAGCTGCCAGAACAGTGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTAAACTCTGTGCTACAAGGCGC
AGTGCTGGAATTCCTTTCTACATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGTTGAAAATAACAATGAAAGAG
TTAATCTCTTTGGCTGGGCCTACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCCTTAGAGCATTGTTCAGAGAT
ACGCGCCTGGGAGAAAATATTATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACATCACCGGTCTGGGCAGTGCGA
AATTCATCCACACTTCTCTTTAGTGCCTTGATCACAAGAATTTTTGGAGTTAAAAGGGCAAAGGATGAACATTCCAAAACAAATAGAATG
ACAGGGAGAGAGTTTTTCTCTCGTTTCCCAGAACTCTATCCTTTTCTTCTCAAACAGTTGGAAACTGTAGCCAATACAGTAGACAGTGAT
ATGGGAGAACCAAATCGTCATCCAAGCATGTTTCTCTTACTTTTGGTGTTGGAGAGACTCTACGCTTCCCCGATGGATGGTACTTCTTCT
GCTCTCAGCATGGGACCTTTTGTTCCCTTCATTATGAGCAGCAAACCAAATCCCAACCAAATATCCACTAGTAATGGGAAGCCTGGTGCT
GTGAATGGAGCTGTGGGGACCACGTTCCAGCCTCAGAATCCTCTCTTAGGGAGAGCCTGTGAGAGCTGCTATGCTACACAGTCTCACCAG
TGGTATTCTTGGGGCCCACCTAATATGCAGTGTAGATTATGTGCAATTTGTTGGCTTTATTGGAAAAAATATGGAGGCTTGAAAATGCCC
ACCCAGTCAGAAGAAGAGAAGTTATCTCCTAGCCCAACTACAGAGGACCCTCGTGTTAGAAGTCACGTGTCCCGCCAGGCCATGCAGGGA
ATGCCAGTCCGAAACACTGGGAGTCCAAAGTCTGCAGTGAAGACCCGCCAAGCTTTCTTCCTTCATACTACATATTTCACAAAATTTGCT
CGTCAGGTCTGCAAAAATACCCTCCGGCTGCGGCAGGCAGCAAGACGGCCGTTTGTTGCTATTAATTATGCTGCCATTAGGGCAGAATAT
GCAGACAGACATGCTGAACTATCTGGAAGTCCACTGAAAAGCAAAAGCACTAGGAAGCCTTTGGCATGTATCATTGGGTATTTAGAGATC
CATCCTGCAAAGAAACCTAATGTAATTCGATCTACACCAAGCCTGCAAACCCCAACTACCAAGCGGATGCTAACAACTCCAAATCACACA

>In-frame_ENST00000330266_ENST00000405094_TCGA-HU-A4GN-01A_THADA_chr2_43655239_-_MTA3_chr2_42931337_length(amino acids)=1315AA_start in transcript=0_stop in transcript=3947
MSSCRSLCCGDISQSAVLFLCQGTLAMLDWQNGSMGRSGEALLLDTAHVLFTLSSQIKEPTLEMFLSRILASWTNSAIQVLESSSPSLTD
SLNGNSSIVGRLLEYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVEGADFVPDPFFVELTESLLRLEWHIKGKYTCLGCLVECIGVEHI
LAIDKTIPSQILEVMGDQSLVPYASDLLETMFRNHKSHLKSQTAESSWIDQWHETWVSPLLFILCEGNLDQKSYVIDYYLPKLLSYSPES
LQYMVKILQTSIDAKTGQEQSFPSLGSCNSRGALGALMACLRIARAHGHLQSATDTWENLVSDARIKQGLIHQHCQVRIDTLGLLCESNR
STEIVSMEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKLEQSKSKREPENELTKQHPSVSLQQYKNFMSSICNSLF
EALFPGSSYSTRFSALTILGSIAEVFHVPEGRIYTVYQLSHDIDVGRFQTLMECFTSTFEDVKILAFDLLMKLSKTAVHFQDSGKLQGLF
QAALELSTSTKPYDCVTASYLLNFLIWQDALPSSLSAYLTQQVACDNGDRPAAVVERNTLMVIKCLMENLEEEVSQAENSLLQAAAAFPM
YGRVHCITGALQKLSLNSLQLVSEWRPVVEKLLLMSYRLSTVVSPVIQSSSPEGLIPMDTDSESASRLQMILNEIQPRDTNDYFNQAKIL
KEHDSFDMKDLNASVVNIDTSTEIKGKEVKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPMQPVPESSDGLLTVEQVKEIGDYFKQHL
LQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKE
LISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWAVRNSSTLLFSALITRIFGVKRAKDEHSKTNRM
TGREFFSRFPELYPFLLKQLETVANTVDSDMGEPNRHPSMFLLLLVLERLYASPMDGTSSALSMGPFVPFIMSSKPNPNQISTSNGKPGA
VNGAVGTTFQPQNPLLGRACESCYATQSHQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEKLSPSPTTEDPRVRSHVSRQAMQG
MPVRNTGSPKSAVKTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVAINYAAIRAEYADRHAELSGSPLKSKSTRKPLACIIGYLEI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for THADA-MTA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for THADA-MTA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for THADA-MTA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTHADAC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human