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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:THEMIS2-RAB35 (FusionGDB2 ID:90012)

Fusion Gene Summary for THEMIS2-RAB35

check button Fusion gene summary
Fusion gene informationFusion gene name: THEMIS2-RAB35
Fusion gene ID: 90012
HgeneTgene
Gene symbol

THEMIS2

RAB35

Gene ID

9473

11021

Gene namethymocyte selection associated family member 2RAB35, member RAS oncogene family
SynonymsC1orf38|ICB-1|ICB1H-ray|RAB1C|RAY
Cytomap

1p35.3

12q24.23

Type of geneprotein-codingprotein-coding
Descriptionprotein THEMIS2basement membrane-inducedinduced by contact to basement membrane 1 proteinprotein ICB-1thymocyte-expressed molecule involved in selection protein 2ras-related protein Rab-35GTP-binding protein RAYras-related protein rab-1c (GTP-binding protein ray)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000373925, ENST00000328928, 
ENST00000373927, ENST00000373921, 
ENST00000492877, 		ENST00000229340, 
ENST00000432953, ENST00000534951, 
ENST00000543364, 
Fusion gene scores* DoF score3 X 2 X 2=124 X 4 X 3=48
# samples 35
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: THEMIS2 [Title/Abstract] AND RAB35 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTHEMIS2(28199176)-RAB35(120546271), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across THEMIS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RAB35 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315406THEMIS2chr1

28199176

+RAB35chr12

120546271

-


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Fusion Gene ORF analysis for THEMIS2-RAB35

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000373925ENST00000229340THEMIS2chr1

28199176

+RAB35chr12

120546271

-
5CDS-intronENST00000373925ENST00000432953THEMIS2chr1

28199176

+RAB35chr12

120546271

-
5CDS-intronENST00000373925ENST00000534951THEMIS2chr1

28199176

+RAB35chr12

120546271

-
5CDS-intronENST00000373925ENST00000543364THEMIS2chr1

28199176

+RAB35chr12

120546271

-
In-frameENST00000328928ENST00000229340THEMIS2chr1

28199176

+RAB35chr12

120546271

-
5CDS-intronENST00000328928ENST00000432953THEMIS2chr1

28199176

+RAB35chr12

120546271

-
5CDS-intronENST00000328928ENST00000534951THEMIS2chr1

28199176

+RAB35chr12

120546271

-
5CDS-intronENST00000328928ENST00000543364THEMIS2chr1

28199176

+RAB35chr12

120546271

-
In-frameENST00000373927ENST00000229340THEMIS2chr1

28199176

+RAB35chr12

120546271

-
5CDS-intronENST00000373927ENST00000432953THEMIS2chr1

28199176

+RAB35chr12

120546271

-
5CDS-intronENST00000373927ENST00000534951THEMIS2chr1

28199176

+RAB35chr12

120546271

-
5CDS-intronENST00000373927ENST00000543364THEMIS2chr1

28199176

+RAB35chr12

120546271

-
In-frameENST00000373921ENST00000229340THEMIS2chr1

28199176

+RAB35chr12

120546271

-
5CDS-intronENST00000373921ENST00000432953THEMIS2chr1

28199176

+RAB35chr12

120546271

-
5CDS-intronENST00000373921ENST00000534951THEMIS2chr1

28199176

+RAB35chr12

120546271

-
5CDS-intronENST00000373921ENST00000543364THEMIS2chr1

28199176

+RAB35chr12

120546271

-
intron-3CDSENST00000492877ENST00000229340THEMIS2chr1

28199176

+RAB35chr12

120546271

-
intron-intronENST00000492877ENST00000432953THEMIS2chr1

28199176

+RAB35chr12

120546271

-
intron-intronENST00000492877ENST00000534951THEMIS2chr1

28199176

+RAB35chr12

120546271

-
intron-intronENST00000492877ENST00000543364THEMIS2chr1

28199176

+RAB35chr12

120546271

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373925THEMIS2chr128199176+ENST00000229340RAB35chr12120546271-28261226661505279
ENST00000328928THEMIS2chr128199176+ENST00000229340RAB35chr12120546271-28261226661505279
ENST00000373927THEMIS2chr128199176+ENST00000229340RAB35chr12120546271-28211176611500279
ENST00000373921THEMIS2chr128199176+ENST00000229340RAB35chr12120546271-2802986421481279

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373925ENST00000229340THEMIS2chr128199176+RAB35chr12120546271-0.344821660.6551783
ENST00000328928ENST00000229340THEMIS2chr128199176+RAB35chr12120546271-0.344821660.6551783
ENST00000373927ENST00000229340THEMIS2chr128199176+RAB35chr12120546271-0.358475420.64152455
ENST00000373921ENST00000229340THEMIS2chr128199176+RAB35chr12120546271-0.331098020.668902

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Fusion Genomic Features for THEMIS2-RAB35


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for THEMIS2-RAB35


check button Go to

FGviewer for the breakpoints of chr1:28199176-chr12:120546271

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRAB35chr1:28199176chr12:120546271ENST000002293400637_4517.333333333333332202.0MotifEffector region
TgeneRAB35chr1:28199176chr12:120546271ENST000005349510537_4517.333333333333332153.0MotifEffector region
TgeneRAB35chr1:28199176chr12:120546271ENST0000022934006120_12317.333333333333332202.0Nucleotide bindingGTP
TgeneRAB35chr1:28199176chr12:120546271ENST0000022934006150_15217.333333333333332202.0Nucleotide bindingGTP
TgeneRAB35chr1:28199176chr12:120546271ENST000002293400615_2317.333333333333332202.0Nucleotide bindingGTP
TgeneRAB35chr1:28199176chr12:120546271ENST000002293400633_4017.333333333333332202.0Nucleotide bindingGTP
TgeneRAB35chr1:28199176chr12:120546271ENST000002293400663_6717.333333333333332202.0Nucleotide bindingGTP
TgeneRAB35chr1:28199176chr12:120546271ENST0000053495105120_12317.333333333333332153.0Nucleotide bindingGTP
TgeneRAB35chr1:28199176chr12:120546271ENST0000053495105150_15217.333333333333332153.0Nucleotide bindingGTP
TgeneRAB35chr1:28199176chr12:120546271ENST000005349510515_2317.333333333333332153.0Nucleotide bindingGTP
TgeneRAB35chr1:28199176chr12:120546271ENST000005349510533_4017.333333333333332153.0Nucleotide bindingGTP
TgeneRAB35chr1:28199176chr12:120546271ENST000005349510563_6717.333333333333332153.0Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHEMIS2chr1:28199176chr12:120546271ENST00000328928+17404_40931.333333333333332515.0Compositional biasNote=Poly-Glu
HgeneTHEMIS2chr1:28199176chr12:120546271ENST00000328928+17626_63731.333333333333332515.0Compositional biasNote=Asp/Glu-rich
HgeneTHEMIS2chr1:28199176chr12:120546271ENST00000373921+16404_40931.333333333333332644.0Compositional biasNote=Poly-Glu
HgeneTHEMIS2chr1:28199176chr12:120546271ENST00000373921+16626_63731.333333333333332644.0Compositional biasNote=Asp/Glu-rich
HgeneTHEMIS2chr1:28199176chr12:120546271ENST00000373925+15404_40931.333333333333332493.3333333333333Compositional biasNote=Poly-Glu
HgeneTHEMIS2chr1:28199176chr12:120546271ENST00000373925+15626_63731.333333333333332493.3333333333333Compositional biasNote=Asp/Glu-rich
HgeneTHEMIS2chr1:28199176chr12:120546271ENST00000373927+14404_40931.333333333333332307.3333333333333Compositional biasNote=Poly-Glu
HgeneTHEMIS2chr1:28199176chr12:120546271ENST00000373927+14626_63731.333333333333332307.3333333333333Compositional biasNote=Asp/Glu-rich
HgeneTHEMIS2chr1:28199176chr12:120546271ENST00000328928+171_23831.333333333333332515.0RegionNote=CABIT 1
HgeneTHEMIS2chr1:28199176chr12:120546271ENST00000328928+17239_51431.333333333333332515.0RegionNote=CABIT 2
HgeneTHEMIS2chr1:28199176chr12:120546271ENST00000373921+161_23831.333333333333332644.0RegionNote=CABIT 1
HgeneTHEMIS2chr1:28199176chr12:120546271ENST00000373921+16239_51431.333333333333332644.0RegionNote=CABIT 2
HgeneTHEMIS2chr1:28199176chr12:120546271ENST00000373925+151_23831.333333333333332493.3333333333333RegionNote=CABIT 1
HgeneTHEMIS2chr1:28199176chr12:120546271ENST00000373925+15239_51431.333333333333332493.3333333333333RegionNote=CABIT 2
HgeneTHEMIS2chr1:28199176chr12:120546271ENST00000373927+141_23831.333333333333332307.3333333333333RegionNote=CABIT 1
HgeneTHEMIS2chr1:28199176chr12:120546271ENST00000373927+14239_51431.333333333333332307.3333333333333RegionNote=CABIT 2


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Fusion Gene Sequence for THEMIS2-RAB35


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000373925_ENST00000229340_ERR315406_THEMIS2_chr1_28199176_+_RAB35_chr12_120546271_length(transcript)=2826nt_BP=122nt
AGTCTGAGCCCAGAGAGCCGCGGGGACCATGGAGCCGGTGCCGCTGCAGGACTTCGTGCGCGCCTTGGACCCCGCCTCCCTCCCGCGCGT
GCTGCGGGTCTGCTCGGGGGTCTACTTCGAGGGTGTGGGCAAGAGCAGTTTACTGTTGCGTTTTGCAGACAACACTTTCTCAGGCAGCTA
CATCACCACGATCGGAGTGGATTTCAAGATCCGGACCGTGGAGATCAACGGGGAGAAGGTGAAGCTGCAGATCTGGGACACAGCGGGGCA
GGAGCGCTTCCGCACCATCACCTCCACGTATTATCGGGGGACCCACGGGGTCATTGTGGTTTACGACGTCACCAGTGCCGAGTCCTTTGT
CAACGTCAAGCGGTGGCTTCACGAAATCAACCAGAACTGTGATGATGTGTGCCGAATATTAGTGGGTAATAAGAATGACGACCCTGAGCG
GAAGGTGGTGGAGACGGAAGATGCCTACAAATTCGCCGGGCAGATGGGCATCCAGTTGTTCGAGACCAGCGCCAAGGAGAATGTCAACGT
GGAAGAGATGTTCAACTGCATCACGGAGCTGGTCCTCCGAGCAAAGAAAGACAACCTGGCAAAACAGCAGCAGCAACAACAGAACGATGT
GGTGAAGCTCACGAAGAACAGTAAACGAAAGAAACGCTGCTGCTAATGGCACCCAGTCCACTGCAGAGACTGCACTGCGGTCCCTCCCCC
AGCCCGAGGCCCACGGAGGTTCCTCGGGGGACAGTCTCAGTTTCGTGCCGTTATTTAAAGAATTCTCTCCATGTTTTTGTATCGGGAGGT
GCCATCGGCACTTCCTCCCCCGCCCTCCTCGAGTGCCAAGAAGGTGTTGGACCAGCCCGCCCTTCCCTACTGGTGCCCCCTCCTCCCCGG
CCAAGGCGCCTGGACCTGGCGAGGACGCTGCCCGCCGAGCGGACTGATTCGCAGAGTCTGTACATAGTGTATATTGCTCTACCCGGCCGC
ACACCACGTCCTGCTCTGGCTTTTGCCTTCTTGATGCCAGCCTGCTGCAACAGACCCTCCCCGCGCCCCTCCCCAGCCCATCTTACTGCA
AGCAGCGTCCTGAGGAGACAGCGGCACGTTCTAGCTGCGTCTGCGGCCAGCCCGTGCCAGTGGAGTGGGCTCCGCGTTGCTCATTCTCTC
CGACAGGTTGTCAGCCTCTGTCCCCGCTGCACAGGGTCTTGCCCCTTCTCCGGGGCCTGTGCCAGCTCCCTTCCCTCCCCGTTGTCCTGT
CCCCACAGCCATTCTGGGAGCTGGGGAACCTGGTCTCAAGGCAGGCCCTGCAGTTCCACAGAGGTGGCAGGTCTTGCCCTTTGGCCAACA
GATTTCTTGTCCTGCCTTCTAGATGCCTCTGAGCTCCAAACCCAGGGCAGCCATGGCTTCTCATTTACACCAACAGGTTTCAGTTCCAAC
AGAAAGGTCGGGGTAGGTTCGTGCAGAGATGGGGCTGGCAGGGGGGCTATGGGAGGATTATTTTAACAGATCAAGAAAATGAAGCCAAAT
CAAGTGAATTAAATTCCTCACAATTATTTTCTTTCCCTGAGGTTTGATTGGCACAGCAGCAAAAGTTGAGGCCACCCCACTTGTGTCCAC
TGTTTTTAGAAAAAAATGAATGGCTTCCTGCCATTGTGGGGCTGGACTCTTGGGCTTTCTTGGTGGGAGCGGAGAAGGGGCCTCCCACCC
TTGTCCGAGTTGCCTCCCACTGGAGGTCAGGAGTCTACACTGCAGCCTCGGGCACTGTGGGGAGTGCATGCCTGGGGCCTCTGGGTGGGG
ACCATGGACAGGCCCTGGTCACTGTCCTAACCTTTGTCAGGACAAAGGTAGCAAGAGGATTTCCTGGCGGGTGGGAAGGAATGGCTGGGG
CGGCCAGTTTTGACACGCCCCAGTGCCCTGGAGAACAACCAGGGTCATCTGCACTTGATGACTGCTCCCCGACCCCCAGCCCGGACACCT
CATTCCCCTCCCACTACAGGGATCAAGTGACCTGGGAAGAACCGAGTTTAACACCAGGATGTGTTTCCTTAGATTTCCTTTCCTAGGCGA
TTTCCAGGGAGAGCCCTGATTGGACAATCACATCACAGATCACACTGCAGTTTCCATGTTAGCACTGTGGATGGGTTTTTAATCAATAAA
AACTGGGGGTTTCTTCTCACCGACTCTCCACTTGCCCAAACTGCCAAAAGCTGGTGATTCTGGGACAGGCCTTCACTTTGGAGCCACGGG
ATGGGGTGGGGGAGCCCCATGGGCCTGGGAAGGAGGGTGCTGTGGAGGGGGCTGCAGGGCTGACCAGCAGGCAGCCTCATCTGGTCGGGG
GCGGGGGCGGCAGGAGCAGAAGCGGGGTCTCCGTCCTTGGGACTGTCCTGGTTGGCCACGGGCCCTGAGGATGCACGGTGCCTGGGGCTC
CTGTGCCGGTGGGCGGGGGGCATGCTGGCCTCTGAGCGATCAGGCGAGGCCAGCGAGGGTGTGCTTGCAAATTCAAGCAATAAGAGGGGG
GTTCCTGGGGGCTTCCAGCCCAGGCTAGAAGCCCCCATGGCTTCTGGCAGCTGGACATCAGCCCCAGGTATTGGGGTGATTTTGGTCATG
ACAGTGTGCCTGTCCCACTGTTACACGCATGAATGGGGGTTATGGGGTGGGGGTGGGGACTCAGGGCTGGACCGACGTCCTAGTGGACCT
GATGTGAAATTCCTGTCAAACAAACACCACTTTTCAATGGTTTGCTAGGAGTATTTCTGTATTGAAAGTTTCTAATTATGCTTTTTAAAA

>In-frame_ENST00000373925_ENST00000229340_ERR315406_THEMIS2_chr1_28199176_+_RAB35_chr12_120546271_length(amino acids)=279AA_start in transcript=666_stop in transcript=1505
MLLMAPSPLQRLHCGPSPSPRPTEVPRGTVSVSCRYLKNSLHVFVSGGAIGTSSPALLECQEGVGPARPSLLVPPPPRPRRLDLARTLPA
ERTDSQSLYIVYIALPGRTPRPALAFAFLMPACCNRPSPRPSPAHLTASSVLRRQRHVLAASAASPCQWSGLRVAHSLRQVVSLCPRCTG
SCPFSGACASSLPSPLSCPHSHSGSWGTWSQGRPCSSTEVAGLALWPTDFLSCLLDASELQTQGSHGFSFTPTGFSSNRKVGVGSCRDGA

--------------------------------------------------------------
>In-frame_ENST00000328928_ENST00000229340_ERR315406_THEMIS2_chr1_28199176_+_RAB35_chr12_120546271_length(transcript)=2826nt_BP=122nt
AGTCTGAGCCCAGAGAGCCGCGGGGACCATGGAGCCGGTGCCGCTGCAGGACTTCGTGCGCGCCTTGGACCCCGCCTCCCTCCCGCGCGT
GCTGCGGGTCTGCTCGGGGGTCTACTTCGAGGGTGTGGGCAAGAGCAGTTTACTGTTGCGTTTTGCAGACAACACTTTCTCAGGCAGCTA
CATCACCACGATCGGAGTGGATTTCAAGATCCGGACCGTGGAGATCAACGGGGAGAAGGTGAAGCTGCAGATCTGGGACACAGCGGGGCA
GGAGCGCTTCCGCACCATCACCTCCACGTATTATCGGGGGACCCACGGGGTCATTGTGGTTTACGACGTCACCAGTGCCGAGTCCTTTGT
CAACGTCAAGCGGTGGCTTCACGAAATCAACCAGAACTGTGATGATGTGTGCCGAATATTAGTGGGTAATAAGAATGACGACCCTGAGCG
GAAGGTGGTGGAGACGGAAGATGCCTACAAATTCGCCGGGCAGATGGGCATCCAGTTGTTCGAGACCAGCGCCAAGGAGAATGTCAACGT
GGAAGAGATGTTCAACTGCATCACGGAGCTGGTCCTCCGAGCAAAGAAAGACAACCTGGCAAAACAGCAGCAGCAACAACAGAACGATGT
GGTGAAGCTCACGAAGAACAGTAAACGAAAGAAACGCTGCTGCTAATGGCACCCAGTCCACTGCAGAGACTGCACTGCGGTCCCTCCCCC
AGCCCGAGGCCCACGGAGGTTCCTCGGGGGACAGTCTCAGTTTCGTGCCGTTATTTAAAGAATTCTCTCCATGTTTTTGTATCGGGAGGT
GCCATCGGCACTTCCTCCCCCGCCCTCCTCGAGTGCCAAGAAGGTGTTGGACCAGCCCGCCCTTCCCTACTGGTGCCCCCTCCTCCCCGG
CCAAGGCGCCTGGACCTGGCGAGGACGCTGCCCGCCGAGCGGACTGATTCGCAGAGTCTGTACATAGTGTATATTGCTCTACCCGGCCGC
ACACCACGTCCTGCTCTGGCTTTTGCCTTCTTGATGCCAGCCTGCTGCAACAGACCCTCCCCGCGCCCCTCCCCAGCCCATCTTACTGCA
AGCAGCGTCCTGAGGAGACAGCGGCACGTTCTAGCTGCGTCTGCGGCCAGCCCGTGCCAGTGGAGTGGGCTCCGCGTTGCTCATTCTCTC
CGACAGGTTGTCAGCCTCTGTCCCCGCTGCACAGGGTCTTGCCCCTTCTCCGGGGCCTGTGCCAGCTCCCTTCCCTCCCCGTTGTCCTGT
CCCCACAGCCATTCTGGGAGCTGGGGAACCTGGTCTCAAGGCAGGCCCTGCAGTTCCACAGAGGTGGCAGGTCTTGCCCTTTGGCCAACA
GATTTCTTGTCCTGCCTTCTAGATGCCTCTGAGCTCCAAACCCAGGGCAGCCATGGCTTCTCATTTACACCAACAGGTTTCAGTTCCAAC
AGAAAGGTCGGGGTAGGTTCGTGCAGAGATGGGGCTGGCAGGGGGGCTATGGGAGGATTATTTTAACAGATCAAGAAAATGAAGCCAAAT
CAAGTGAATTAAATTCCTCACAATTATTTTCTTTCCCTGAGGTTTGATTGGCACAGCAGCAAAAGTTGAGGCCACCCCACTTGTGTCCAC
TGTTTTTAGAAAAAAATGAATGGCTTCCTGCCATTGTGGGGCTGGACTCTTGGGCTTTCTTGGTGGGAGCGGAGAAGGGGCCTCCCACCC
TTGTCCGAGTTGCCTCCCACTGGAGGTCAGGAGTCTACACTGCAGCCTCGGGCACTGTGGGGAGTGCATGCCTGGGGCCTCTGGGTGGGG
ACCATGGACAGGCCCTGGTCACTGTCCTAACCTTTGTCAGGACAAAGGTAGCAAGAGGATTTCCTGGCGGGTGGGAAGGAATGGCTGGGG
CGGCCAGTTTTGACACGCCCCAGTGCCCTGGAGAACAACCAGGGTCATCTGCACTTGATGACTGCTCCCCGACCCCCAGCCCGGACACCT
CATTCCCCTCCCACTACAGGGATCAAGTGACCTGGGAAGAACCGAGTTTAACACCAGGATGTGTTTCCTTAGATTTCCTTTCCTAGGCGA
TTTCCAGGGAGAGCCCTGATTGGACAATCACATCACAGATCACACTGCAGTTTCCATGTTAGCACTGTGGATGGGTTTTTAATCAATAAA
AACTGGGGGTTTCTTCTCACCGACTCTCCACTTGCCCAAACTGCCAAAAGCTGGTGATTCTGGGACAGGCCTTCACTTTGGAGCCACGGG
ATGGGGTGGGGGAGCCCCATGGGCCTGGGAAGGAGGGTGCTGTGGAGGGGGCTGCAGGGCTGACCAGCAGGCAGCCTCATCTGGTCGGGG
GCGGGGGCGGCAGGAGCAGAAGCGGGGTCTCCGTCCTTGGGACTGTCCTGGTTGGCCACGGGCCCTGAGGATGCACGGTGCCTGGGGCTC
CTGTGCCGGTGGGCGGGGGGCATGCTGGCCTCTGAGCGATCAGGCGAGGCCAGCGAGGGTGTGCTTGCAAATTCAAGCAATAAGAGGGGG
GTTCCTGGGGGCTTCCAGCCCAGGCTAGAAGCCCCCATGGCTTCTGGCAGCTGGACATCAGCCCCAGGTATTGGGGTGATTTTGGTCATG
ACAGTGTGCCTGTCCCACTGTTACACGCATGAATGGGGGTTATGGGGTGGGGGTGGGGACTCAGGGCTGGACCGACGTCCTAGTGGACCT
GATGTGAAATTCCTGTCAAACAAACACCACTTTTCAATGGTTTGCTAGGAGTATTTCTGTATTGAAAGTTTCTAATTATGCTTTTTAAAA

>In-frame_ENST00000328928_ENST00000229340_ERR315406_THEMIS2_chr1_28199176_+_RAB35_chr12_120546271_length(amino acids)=279AA_start in transcript=666_stop in transcript=1505
MLLMAPSPLQRLHCGPSPSPRPTEVPRGTVSVSCRYLKNSLHVFVSGGAIGTSSPALLECQEGVGPARPSLLVPPPPRPRRLDLARTLPA
ERTDSQSLYIVYIALPGRTPRPALAFAFLMPACCNRPSPRPSPAHLTASSVLRRQRHVLAASAASPCQWSGLRVAHSLRQVVSLCPRCTG
SCPFSGACASSLPSPLSCPHSHSGSWGTWSQGRPCSSTEVAGLALWPTDFLSCLLDASELQTQGSHGFSFTPTGFSSNRKVGVGSCRDGA

--------------------------------------------------------------
>In-frame_ENST00000373927_ENST00000229340_ERR315406_THEMIS2_chr1_28199176_+_RAB35_chr12_120546271_length(transcript)=2821nt_BP=117nt
GAGCCCAGAGAGCCGCGGGGACCATGGAGCCGGTGCCGCTGCAGGACTTCGTGCGCGCCTTGGACCCCGCCTCCCTCCCGCGCGTGCTGC
GGGTCTGCTCGGGGGTCTACTTCGAGGGTGTGGGCAAGAGCAGTTTACTGTTGCGTTTTGCAGACAACACTTTCTCAGGCAGCTACATCA
CCACGATCGGAGTGGATTTCAAGATCCGGACCGTGGAGATCAACGGGGAGAAGGTGAAGCTGCAGATCTGGGACACAGCGGGGCAGGAGC
GCTTCCGCACCATCACCTCCACGTATTATCGGGGGACCCACGGGGTCATTGTGGTTTACGACGTCACCAGTGCCGAGTCCTTTGTCAACG
TCAAGCGGTGGCTTCACGAAATCAACCAGAACTGTGATGATGTGTGCCGAATATTAGTGGGTAATAAGAATGACGACCCTGAGCGGAAGG
TGGTGGAGACGGAAGATGCCTACAAATTCGCCGGGCAGATGGGCATCCAGTTGTTCGAGACCAGCGCCAAGGAGAATGTCAACGTGGAAG
AGATGTTCAACTGCATCACGGAGCTGGTCCTCCGAGCAAAGAAAGACAACCTGGCAAAACAGCAGCAGCAACAACAGAACGATGTGGTGA
AGCTCACGAAGAACAGTAAACGAAAGAAACGCTGCTGCTAATGGCACCCAGTCCACTGCAGAGACTGCACTGCGGTCCCTCCCCCAGCCC
GAGGCCCACGGAGGTTCCTCGGGGGACAGTCTCAGTTTCGTGCCGTTATTTAAAGAATTCTCTCCATGTTTTTGTATCGGGAGGTGCCAT
CGGCACTTCCTCCCCCGCCCTCCTCGAGTGCCAAGAAGGTGTTGGACCAGCCCGCCCTTCCCTACTGGTGCCCCCTCCTCCCCGGCCAAG
GCGCCTGGACCTGGCGAGGACGCTGCCCGCCGAGCGGACTGATTCGCAGAGTCTGTACATAGTGTATATTGCTCTACCCGGCCGCACACC
ACGTCCTGCTCTGGCTTTTGCCTTCTTGATGCCAGCCTGCTGCAACAGACCCTCCCCGCGCCCCTCCCCAGCCCATCTTACTGCAAGCAG
CGTCCTGAGGAGACAGCGGCACGTTCTAGCTGCGTCTGCGGCCAGCCCGTGCCAGTGGAGTGGGCTCCGCGTTGCTCATTCTCTCCGACA
GGTTGTCAGCCTCTGTCCCCGCTGCACAGGGTCTTGCCCCTTCTCCGGGGCCTGTGCCAGCTCCCTTCCCTCCCCGTTGTCCTGTCCCCA
CAGCCATTCTGGGAGCTGGGGAACCTGGTCTCAAGGCAGGCCCTGCAGTTCCACAGAGGTGGCAGGTCTTGCCCTTTGGCCAACAGATTT
CTTGTCCTGCCTTCTAGATGCCTCTGAGCTCCAAACCCAGGGCAGCCATGGCTTCTCATTTACACCAACAGGTTTCAGTTCCAACAGAAA
GGTCGGGGTAGGTTCGTGCAGAGATGGGGCTGGCAGGGGGGCTATGGGAGGATTATTTTAACAGATCAAGAAAATGAAGCCAAATCAAGT
GAATTAAATTCCTCACAATTATTTTCTTTCCCTGAGGTTTGATTGGCACAGCAGCAAAAGTTGAGGCCACCCCACTTGTGTCCACTGTTT
TTAGAAAAAAATGAATGGCTTCCTGCCATTGTGGGGCTGGACTCTTGGGCTTTCTTGGTGGGAGCGGAGAAGGGGCCTCCCACCCTTGTC
CGAGTTGCCTCCCACTGGAGGTCAGGAGTCTACACTGCAGCCTCGGGCACTGTGGGGAGTGCATGCCTGGGGCCTCTGGGTGGGGACCAT
GGACAGGCCCTGGTCACTGTCCTAACCTTTGTCAGGACAAAGGTAGCAAGAGGATTTCCTGGCGGGTGGGAAGGAATGGCTGGGGCGGCC
AGTTTTGACACGCCCCAGTGCCCTGGAGAACAACCAGGGTCATCTGCACTTGATGACTGCTCCCCGACCCCCAGCCCGGACACCTCATTC
CCCTCCCACTACAGGGATCAAGTGACCTGGGAAGAACCGAGTTTAACACCAGGATGTGTTTCCTTAGATTTCCTTTCCTAGGCGATTTCC
AGGGAGAGCCCTGATTGGACAATCACATCACAGATCACACTGCAGTTTCCATGTTAGCACTGTGGATGGGTTTTTAATCAATAAAAACTG
GGGGTTTCTTCTCACCGACTCTCCACTTGCCCAAACTGCCAAAAGCTGGTGATTCTGGGACAGGCCTTCACTTTGGAGCCACGGGATGGG
GTGGGGGAGCCCCATGGGCCTGGGAAGGAGGGTGCTGTGGAGGGGGCTGCAGGGCTGACCAGCAGGCAGCCTCATCTGGTCGGGGGCGGG
GGCGGCAGGAGCAGAAGCGGGGTCTCCGTCCTTGGGACTGTCCTGGTTGGCCACGGGCCCTGAGGATGCACGGTGCCTGGGGCTCCTGTG
CCGGTGGGCGGGGGGCATGCTGGCCTCTGAGCGATCAGGCGAGGCCAGCGAGGGTGTGCTTGCAAATTCAAGCAATAAGAGGGGGGTTCC
TGGGGGCTTCCAGCCCAGGCTAGAAGCCCCCATGGCTTCTGGCAGCTGGACATCAGCCCCAGGTATTGGGGTGATTTTGGTCATGACAGT
GTGCCTGTCCCACTGTTACACGCATGAATGGGGGTTATGGGGTGGGGGTGGGGACTCAGGGCTGGACCGACGTCCTAGTGGACCTGATGT
GAAATTCCTGTCAAACAAACACCACTTTTCAATGGTTTGCTAGGAGTATTTCTGTATTGAAAGTTTCTAATTATGCTTTTTAAAAAAATA

>In-frame_ENST00000373927_ENST00000229340_ERR315406_THEMIS2_chr1_28199176_+_RAB35_chr12_120546271_length(amino acids)=279AA_start in transcript=661_stop in transcript=1500
MLLMAPSPLQRLHCGPSPSPRPTEVPRGTVSVSCRYLKNSLHVFVSGGAIGTSSPALLECQEGVGPARPSLLVPPPPRPRRLDLARTLPA
ERTDSQSLYIVYIALPGRTPRPALAFAFLMPACCNRPSPRPSPAHLTASSVLRRQRHVLAASAASPCQWSGLRVAHSLRQVVSLCPRCTG
SCPFSGACASSLPSPLSCPHSHSGSWGTWSQGRPCSSTEVAGLALWPTDFLSCLLDASELQTQGSHGFSFTPTGFSSNRKVGVGSCRDGA

--------------------------------------------------------------
>In-frame_ENST00000373921_ENST00000229340_ERR315406_THEMIS2_chr1_28199176_+_RAB35_chr12_120546271_length(transcript)=2802nt_BP=98nt
GACCATGGAGCCGGTGCCGCTGCAGGACTTCGTGCGCGCCTTGGACCCCGCCTCCCTCCCGCGCGTGCTGCGGGTCTGCTCGGGGGTCTA
CTTCGAGGGTGTGGGCAAGAGCAGTTTACTGTTGCGTTTTGCAGACAACACTTTCTCAGGCAGCTACATCACCACGATCGGAGTGGATTT
CAAGATCCGGACCGTGGAGATCAACGGGGAGAAGGTGAAGCTGCAGATCTGGGACACAGCGGGGCAGGAGCGCTTCCGCACCATCACCTC
CACGTATTATCGGGGGACCCACGGGGTCATTGTGGTTTACGACGTCACCAGTGCCGAGTCCTTTGTCAACGTCAAGCGGTGGCTTCACGA
AATCAACCAGAACTGTGATGATGTGTGCCGAATATTAGTGGGTAATAAGAATGACGACCCTGAGCGGAAGGTGGTGGAGACGGAAGATGC
CTACAAATTCGCCGGGCAGATGGGCATCCAGTTGTTCGAGACCAGCGCCAAGGAGAATGTCAACGTGGAAGAGATGTTCAACTGCATCAC
GGAGCTGGTCCTCCGAGCAAAGAAAGACAACCTGGCAAAACAGCAGCAGCAACAACAGAACGATGTGGTGAAGCTCACGAAGAACAGTAA
ACGAAAGAAACGCTGCTGCTAATGGCACCCAGTCCACTGCAGAGACTGCACTGCGGTCCCTCCCCCAGCCCGAGGCCCACGGAGGTTCCT
CGGGGGACAGTCTCAGTTTCGTGCCGTTATTTAAAGAATTCTCTCCATGTTTTTGTATCGGGAGGTGCCATCGGCACTTCCTCCCCCGCC
CTCCTCGAGTGCCAAGAAGGTGTTGGACCAGCCCGCCCTTCCCTACTGGTGCCCCCTCCTCCCCGGCCAAGGCGCCTGGACCTGGCGAGG
ACGCTGCCCGCCGAGCGGACTGATTCGCAGAGTCTGTACATAGTGTATATTGCTCTACCCGGCCGCACACCACGTCCTGCTCTGGCTTTT
GCCTTCTTGATGCCAGCCTGCTGCAACAGACCCTCCCCGCGCCCCTCCCCAGCCCATCTTACTGCAAGCAGCGTCCTGAGGAGACAGCGG
CACGTTCTAGCTGCGTCTGCGGCCAGCCCGTGCCAGTGGAGTGGGCTCCGCGTTGCTCATTCTCTCCGACAGGTTGTCAGCCTCTGTCCC
CGCTGCACAGGGTCTTGCCCCTTCTCCGGGGCCTGTGCCAGCTCCCTTCCCTCCCCGTTGTCCTGTCCCCACAGCCATTCTGGGAGCTGG
GGAACCTGGTCTCAAGGCAGGCCCTGCAGTTCCACAGAGGTGGCAGGTCTTGCCCTTTGGCCAACAGATTTCTTGTCCTGCCTTCTAGAT
GCCTCTGAGCTCCAAACCCAGGGCAGCCATGGCTTCTCATTTACACCAACAGGTTTCAGTTCCAACAGAAAGGTCGGGGTAGGTTCGTGC
AGAGATGGGGCTGGCAGGGGGGCTATGGGAGGATTATTTTAACAGATCAAGAAAATGAAGCCAAATCAAGTGAATTAAATTCCTCACAAT
TATTTTCTTTCCCTGAGGTTTGATTGGCACAGCAGCAAAAGTTGAGGCCACCCCACTTGTGTCCACTGTTTTTAGAAAAAAATGAATGGC
TTCCTGCCATTGTGGGGCTGGACTCTTGGGCTTTCTTGGTGGGAGCGGAGAAGGGGCCTCCCACCCTTGTCCGAGTTGCCTCCCACTGGA
GGTCAGGAGTCTACACTGCAGCCTCGGGCACTGTGGGGAGTGCATGCCTGGGGCCTCTGGGTGGGGACCATGGACAGGCCCTGGTCACTG
TCCTAACCTTTGTCAGGACAAAGGTAGCAAGAGGATTTCCTGGCGGGTGGGAAGGAATGGCTGGGGCGGCCAGTTTTGACACGCCCCAGT
GCCCTGGAGAACAACCAGGGTCATCTGCACTTGATGACTGCTCCCCGACCCCCAGCCCGGACACCTCATTCCCCTCCCACTACAGGGATC
AAGTGACCTGGGAAGAACCGAGTTTAACACCAGGATGTGTTTCCTTAGATTTCCTTTCCTAGGCGATTTCCAGGGAGAGCCCTGATTGGA
CAATCACATCACAGATCACACTGCAGTTTCCATGTTAGCACTGTGGATGGGTTTTTAATCAATAAAAACTGGGGGTTTCTTCTCACCGAC
TCTCCACTTGCCCAAACTGCCAAAAGCTGGTGATTCTGGGACAGGCCTTCACTTTGGAGCCACGGGATGGGGTGGGGGAGCCCCATGGGC
CTGGGAAGGAGGGTGCTGTGGAGGGGGCTGCAGGGCTGACCAGCAGGCAGCCTCATCTGGTCGGGGGCGGGGGCGGCAGGAGCAGAAGCG
GGGTCTCCGTCCTTGGGACTGTCCTGGTTGGCCACGGGCCCTGAGGATGCACGGTGCCTGGGGCTCCTGTGCCGGTGGGCGGGGGGCATG
CTGGCCTCTGAGCGATCAGGCGAGGCCAGCGAGGGTGTGCTTGCAAATTCAAGCAATAAGAGGGGGGTTCCTGGGGGCTTCCAGCCCAGG
CTAGAAGCCCCCATGGCTTCTGGCAGCTGGACATCAGCCCCAGGTATTGGGGTGATTTTGGTCATGACAGTGTGCCTGTCCCACTGTTAC
ACGCATGAATGGGGGTTATGGGGTGGGGGTGGGGACTCAGGGCTGGACCGACGTCCTAGTGGACCTGATGTGAAATTCCTGTCAAACAAA
CACCACTTTTCAATGGTTTGCTAGGAGTATTTCTGTATTGAAAGTTTCTAATTATGCTTTTTAAAAAAATACTAAAAATAAAGGTTCAAG

>In-frame_ENST00000373921_ENST00000229340_ERR315406_THEMIS2_chr1_28199176_+_RAB35_chr12_120546271_length(amino acids)=279AA_start in transcript=642_stop in transcript=1481
MLLMAPSPLQRLHCGPSPSPRPTEVPRGTVSVSCRYLKNSLHVFVSGGAIGTSSPALLECQEGVGPARPSLLVPPPPRPRRLDLARTLPA
ERTDSQSLYIVYIALPGRTPRPALAFAFLMPACCNRPSPRPSPAHLTASSVLRRQRHVLAASAASPCQWSGLRVAHSLRQVVSLCPRCTG
SCPFSGACASSLPSPLSCPHSHSGSWGTWSQGRPCSSTEVAGLALWPTDFLSCLLDASELQTQGSHGFSFTPTGFSSNRKVGVGSCRDGA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for THEMIS2-RAB35


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for THEMIS2-RAB35


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for THEMIS2-RAB35


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTHEMIS2C0006142Malignant neoplasm of breast1CTD_human
HgeneTHEMIS2C0678222Breast Carcinoma1CTD_human
HgeneTHEMIS2C1257931Mammary Neoplasms, Human1CTD_human
HgeneTHEMIS2C1458155Mammary Neoplasms1CTD_human
HgeneTHEMIS2C4704874Mammary Carcinoma, Human1CTD_human