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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:THRAP3-CAPZB (FusionGDB2 ID:90077)

Fusion Gene Summary for THRAP3-CAPZB

check button Fusion gene summary
Fusion gene informationFusion gene name: THRAP3-CAPZB
Fusion gene ID: 90077
HgeneTgene
Gene symbol

THRAP3

CAPZB

Gene ID

9967

832

Gene namethyroid hormone receptor associated protein 3capping actin protein of muscle Z-line subunit beta
SynonymsBCLAF2|TRAP150CAPB|CAPPB|CAPZ
Cytomap

1p34.3

1p36.13

Type of geneprotein-codingprotein-coding
Descriptionthyroid hormone receptor-associated protein 3BCLAF1 and THRAP3 family member 2TR-associated protein, 150-kDathyroid hormone receptor-associated protein complex 150 kDa componentthyroid hormone receptor-associated protein, 150 kDa subunitF-actin-capping protein subunit betacapZ betacapping actin protein of muscle Z-line beta subunitcapping protein (actin filament) muscle Z-line, betaepididymis secretory sperm binding protein
Modification date2020031320200320
UniProtAcc.

P47756

Ensembl transtripts involved in fusion geneENST00000354618, ENST00000469141, 
ENST00000466743, 		ENST00000401084, 
ENST00000264203, ENST00000375142, 
ENST00000433834, ENST00000264202, 
ENST00000482808, ENST00000375144, 
Fusion gene scores* DoF score29 X 11 X 18=574223 X 15 X 8=2760
# samples 4027
** MAII scorelog2(40/5742*10)=-3.84348142543246
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/2760*10)=-3.3536369546147
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: THRAP3 [Title/Abstract] AND CAPZB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTHRAP3(36690106)-CAPZB(19705147), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTHRAP3

GO:0000956

nuclear-transcribed mRNA catabolic process

20123736

HgeneTHRAP3

GO:0006367

transcription initiation from RNA polymerase II promoter

12218053

HgeneTHRAP3

GO:0045893

positive regulation of transcription, DNA-templated

10198638

HgeneTHRAP3

GO:0045944

positive regulation of transcription by RNA polymerase II

12037571


check buttonFusion gene breakpoints across THRAP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CAPZB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-49-4507-01ATHRAP3chr1

36690106

+CAPZBchr1

19705147

-
ChimerDB4LUADTCGA-49-4507THRAP3chr1

36690106

+CAPZBchr1

19705147

-
ChimerDB4LUADTCGA-49-4507-01ATHRAP3chr1

36690106

+CAPZBchr1

19705147

-
ChimerDB4LUADTCGA-49-4507-01ATHRAP3chr1

36690106

-CAPZBchr1

19705147

-


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Fusion Gene ORF analysis for THRAP3-CAPZB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000354618ENST00000401084THRAP3chr1

36690106

+CAPZBchr1

19705147

-
5UTR-3CDSENST00000354618ENST00000264203THRAP3chr1

36690106

+CAPZBchr1

19705147

-
5UTR-3CDSENST00000354618ENST00000375142THRAP3chr1

36690106

+CAPZBchr1

19705147

-
5UTR-3CDSENST00000354618ENST00000433834THRAP3chr1

36690106

+CAPZBchr1

19705147

-
5UTR-3CDSENST00000354618ENST00000264202THRAP3chr1

36690106

+CAPZBchr1

19705147

-
5UTR-5UTRENST00000354618ENST00000482808THRAP3chr1

36690106

+CAPZBchr1

19705147

-
5UTR-5UTRENST00000354618ENST00000375144THRAP3chr1

36690106

+CAPZBchr1

19705147

-
5UTR-3CDSENST00000469141ENST00000401084THRAP3chr1

36690106

+CAPZBchr1

19705147

-
5UTR-3CDSENST00000469141ENST00000264203THRAP3chr1

36690106

+CAPZBchr1

19705147

-
5UTR-3CDSENST00000469141ENST00000375142THRAP3chr1

36690106

+CAPZBchr1

19705147

-
5UTR-3CDSENST00000469141ENST00000433834THRAP3chr1

36690106

+CAPZBchr1

19705147

-
5UTR-3CDSENST00000469141ENST00000264202THRAP3chr1

36690106

+CAPZBchr1

19705147

-
5UTR-5UTRENST00000469141ENST00000482808THRAP3chr1

36690106

+CAPZBchr1

19705147

-
5UTR-5UTRENST00000469141ENST00000375144THRAP3chr1

36690106

+CAPZBchr1

19705147

-
intron-3CDSENST00000466743ENST00000401084THRAP3chr1

36690106

+CAPZBchr1

19705147

-
intron-3CDSENST00000466743ENST00000264203THRAP3chr1

36690106

+CAPZBchr1

19705147

-
intron-3CDSENST00000466743ENST00000375142THRAP3chr1

36690106

+CAPZBchr1

19705147

-
intron-3CDSENST00000466743ENST00000433834THRAP3chr1

36690106

+CAPZBchr1

19705147

-
intron-3CDSENST00000466743ENST00000264202THRAP3chr1

36690106

+CAPZBchr1

19705147

-
intron-5UTRENST00000466743ENST00000482808THRAP3chr1

36690106

+CAPZBchr1

19705147

-
intron-5UTRENST00000466743ENST00000375144THRAP3chr1

36690106

+CAPZBchr1

19705147

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for THRAP3-CAPZB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for THRAP3-CAPZB


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CAPZB

P47756

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for THRAP3-CAPZB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for THRAP3-CAPZB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for THRAP3-CAPZB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for THRAP3-CAPZB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCAPZBC0007097Carcinoma1CTD_human
TgeneCAPZBC0024667Animal Mammary Neoplasms1CTD_human
TgeneCAPZBC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneCAPZBC0205696Anaplastic carcinoma1CTD_human
TgeneCAPZBC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneCAPZBC0205698Undifferentiated carcinoma1CTD_human
TgeneCAPZBC0205699Carcinomatosis1CTD_human
TgeneCAPZBC0948089Acute Coronary Syndrome1CTD_human
TgeneCAPZBC1257925Mammary Carcinoma, Animal1CTD_human