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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TIAM1-PCBP3 (FusionGDB2 ID:90219)

Fusion Gene Summary for TIAM1-PCBP3

check button Fusion gene summary
Fusion gene informationFusion gene name: TIAM1-PCBP3
Fusion gene ID: 90219
HgeneTgene
Gene symbol

TIAM1

PCBP3

Gene ID

7074

54039

Gene nameTIAM Rac1 associated GEF 1poly(rC) binding protein 3
SynonymsTIAM-1ALPHA-CP3|PCBP3-OT1|PCBP3OT
Cytomap

21q22.11

21q22.3

Type of geneprotein-codingprotein-coding
DescriptionT-lymphoma invasion and metastasis-inducing protein 1T cell lymphoma invasion and metastasis 1human T-lymphoma invasion and metastasis inducing TIAM1 proteinpoly(rC)-binding protein 3PCBP3 overlapping transcript 1PCBP3-overlapping transcriptpoly(rC) binding protein 3 overlapping transcript
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000286827, ENST00000541036, 
ENST00000469412, 		ENST00000400314, 
ENST00000400310, ENST00000449640, 
ENST00000400309, ENST00000400308, 
ENST00000400304, ENST00000423045, 
Fusion gene scores* DoF score21 X 17 X 10=35706 X 8 X 4=192
# samples 248
** MAII scorelog2(24/3570*10)=-3.89481776330794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TIAM1 [Title/Abstract] AND PCBP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTIAM1(32711558)-PCBP3(47316122), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTIAM1

GO:0008284

positive regulation of cell proliferation

25032858

HgeneTIAM1

GO:0010717

regulation of epithelial to mesenchymal transition

20826792

HgeneTIAM1

GO:0030335

positive regulation of cell migration

25032858

HgeneTIAM1

GO:0032092

positive regulation of protein binding

23109420

HgeneTIAM1

GO:0034622

cellular protein-containing complex assembly

23109420

HgeneTIAM1

GO:0090630

activation of GTPase activity

23109420


check buttonFusion gene breakpoints across TIAM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PCBP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CR-7367-01ATIAM1chr21

32711558

-PCBP3chr21

47316122

+
ChimerDB4HNSCTCGA-CR-7367TIAM1chr21

32711557

-PCBP3chr21

47316121

+
ChimerDB4HNSCTCGA-CR-7367TIAM1chr21

32711557

-PCBP3chr21

47316121

+
ChimerDB4HNSCTCGA-CR-7367TIAM1chr21

32711558

-PCBP3chr21

47316122

+
ChimerDB4HNSCTCGA-CR-7367-01ATIAM1chr21

32711558

-PCBP3chr21

47316122

+


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Fusion Gene ORF analysis for TIAM1-PCBP3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000286827ENST00000400314TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-3CDSENST00000286827ENST00000400310TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-3CDSENST00000286827ENST00000449640TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-3CDSENST00000286827ENST00000400309TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-3CDSENST00000286827ENST00000400308TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-intronENST00000286827ENST00000400304TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-intronENST00000286827ENST00000423045TIAM1chr21

32711558

-PCBP3chr21

47316122

+
intron-3CDSENST00000541036ENST00000400314TIAM1chr21

32711558

-PCBP3chr21

47316122

+
intron-3CDSENST00000541036ENST00000400310TIAM1chr21

32711558

-PCBP3chr21

47316122

+
intron-3CDSENST00000541036ENST00000449640TIAM1chr21

32711558

-PCBP3chr21

47316122

+
intron-3CDSENST00000541036ENST00000400309TIAM1chr21

32711558

-PCBP3chr21

47316122

+
intron-3CDSENST00000541036ENST00000400308TIAM1chr21

32711558

-PCBP3chr21

47316122

+
intron-intronENST00000541036ENST00000400304TIAM1chr21

32711558

-PCBP3chr21

47316122

+
intron-intronENST00000541036ENST00000423045TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-3CDSENST00000469412ENST00000400314TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-3CDSENST00000469412ENST00000400310TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-3CDSENST00000469412ENST00000449640TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-3CDSENST00000469412ENST00000400309TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-3CDSENST00000469412ENST00000400308TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-intronENST00000469412ENST00000400304TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-intronENST00000469412ENST00000423045TIAM1chr21

32711558

-PCBP3chr21

47316122

+
5UTR-3CDSENST00000286827ENST00000400314TIAM1chr21

32711557

-PCBP3chr21

47316121

+
5UTR-3CDSENST00000286827ENST00000400310TIAM1chr21

32711557

-PCBP3chr21

47316121

+
5UTR-3CDSENST00000286827ENST00000449640TIAM1chr21

32711557

-PCBP3chr21

47316121

+
5UTR-3CDSENST00000286827ENST00000400309TIAM1chr21

32711557

-PCBP3chr21

47316121

+
5UTR-3CDSENST00000286827ENST00000400308TIAM1chr21

32711557

-PCBP3chr21

47316121

+
5UTR-intronENST00000286827ENST00000400304TIAM1chr21

32711557

-PCBP3chr21

47316121

+
5UTR-intronENST00000286827ENST00000423045TIAM1chr21

32711557

-PCBP3chr21

47316121

+
intron-3CDSENST00000541036ENST00000400314TIAM1chr21

32711557

-PCBP3chr21

47316121

+
intron-3CDSENST00000541036ENST00000400310TIAM1chr21

32711557

-PCBP3chr21

47316121

+
intron-3CDSENST00000541036ENST00000449640TIAM1chr21

32711557

-PCBP3chr21

47316121

+
intron-3CDSENST00000541036ENST00000400309TIAM1chr21

32711557

-PCBP3chr21

47316121

+
intron-3CDSENST00000541036ENST00000400308TIAM1chr21

32711557

-PCBP3chr21

47316121

+
intron-intronENST00000541036ENST00000400304TIAM1chr21

32711557

-PCBP3chr21

47316121

+
intron-intronENST00000541036ENST00000423045TIAM1chr21

32711557

-PCBP3chr21

47316121

+
5UTR-3CDSENST00000469412ENST00000400314TIAM1chr21

32711557

-PCBP3chr21

47316121

+
5UTR-3CDSENST00000469412ENST00000400310TIAM1chr21

32711557

-PCBP3chr21

47316121

+
5UTR-3CDSENST00000469412ENST00000449640TIAM1chr21

32711557

-PCBP3chr21

47316121

+
5UTR-3CDSENST00000469412ENST00000400309TIAM1chr21

32711557

-PCBP3chr21

47316121

+
5UTR-3CDSENST00000469412ENST00000400308TIAM1chr21

32711557

-PCBP3chr21

47316121

+
5UTR-intronENST00000469412ENST00000400304TIAM1chr21

32711557

-PCBP3chr21

47316121

+
5UTR-intronENST00000469412ENST00000423045TIAM1chr21

32711557

-PCBP3chr21

47316121

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TIAM1-PCBP3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TIAM1chr2132711557-PCBP3chr2147316121+0.0010244610.9989755
TIAM1chr2132711557-PCBP3chr2147316121+0.0010244610.9989755
TIAM1chr2132711557-PCBP3chr2147316121+0.0010244610.9989755
TIAM1chr2132711557-PCBP3chr2147316121+0.0010244610.9989755

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TIAM1-PCBP3


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TIAM1-PCBP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TIAM1-PCBP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TIAM1-PCBP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TIAM1-PCBP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTIAM1C0007137Squamous cell carcinoma1CTD_human
HgeneTIAM1C0026640Mouth Neoplasms1CTD_human
HgeneTIAM1C0153381Malignant neoplasm of mouth1CTD_human
HgeneTIAM1C1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
HgeneTIAM1C1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
HgeneTIAM1C4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human