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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:TM9SF2-CLYBL (FusionGDB2 ID:90611) |
Fusion Gene Summary for TM9SF2-CLYBL |
Fusion gene summary |
Fusion gene information | Fusion gene name: TM9SF2-CLYBL | Fusion gene ID: 90611 | Hgene | Tgene | Gene symbol | TM9SF2 | CLYBL | Gene ID | 9375 | 171425 |
Gene name | transmembrane 9 superfamily member 2 | citramalyl-CoA lyase | |
Synonyms | P76 | CLB | |
Cytomap | 13q32.3 | 13q32.3 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane 9 superfamily member 276 kDa membrane proteindinucleotide oxidase disulfide thiol exchanger 3 superfamily member 2epididymis secretory sperm binding proteintransmembrane protein 9 superfamily member 2 | citramalyl-CoA lyase, mitochondrial(3S)-malyl-CoA thioesterasebeta-methylmalate synthasecitrate lyase beta likecitrate lyase subunit beta-like protein, mitochondrialmalate synthase | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | Q8N0X4 | |
Ensembl transtripts involved in fusion gene | ENST00000376387, ENST00000463709, | ENST00000376355, ENST00000444838, ENST00000376360, ENST00000376354, ENST00000339105, | |
Fusion gene scores | * DoF score | 8 X 8 X 5=320 | 8 X 7 X 7=392 |
# samples | 8 | 13 | |
** MAII score | log2(8/320*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/392*10)=-1.59234203108675 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TM9SF2 [Title/Abstract] AND CLYBL [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CLYBL(100269143)-TM9SF2(100185960), # samples:1 TM9SF2(100201476)-CLYBL(100425078), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | TM9SF2-CLYBL seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CLYBL | GO:0070207 | protein homotrimerization | 29056341 |
Tgene | CLYBL | GO:0106064 | regulation of cobalamin metabolic process | 29056341 |
Fusion gene breakpoints across TM9SF2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across CLYBL (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-A7-A4SC-01A | TM9SF2 | chr13 | 100201476 | + | CLYBL | chr13 | 100425078 | + |
ChimerDB4 | BRCA | TCGA-A7-A4SC-01A | TM9SF2 | chr13 | 100201476 | + | CLYBL | chr13 | 100425078 | + |
ChimerDB4 | BRCA | TCGA-A7-A4SC-01A | TM9SF2 | chr13 | 100204580 | + | CLYBL | chr13 | 100425078 | + |
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Fusion Gene ORF analysis for TM9SF2-CLYBL |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000376387 | ENST00000376355 | TM9SF2 | chr13 | 100201476 | + | CLYBL | chr13 | 100425078 | + |
In-frame | ENST00000376387 | ENST00000444838 | TM9SF2 | chr13 | 100201476 | + | CLYBL | chr13 | 100425078 | + |
In-frame | ENST00000376387 | ENST00000376360 | TM9SF2 | chr13 | 100201476 | + | CLYBL | chr13 | 100425078 | + |
In-frame | ENST00000376387 | ENST00000376354 | TM9SF2 | chr13 | 100201476 | + | CLYBL | chr13 | 100425078 | + |
In-frame | ENST00000376387 | ENST00000339105 | TM9SF2 | chr13 | 100201476 | + | CLYBL | chr13 | 100425078 | + |
intron-3CDS | ENST00000463709 | ENST00000376355 | TM9SF2 | chr13 | 100201476 | + | CLYBL | chr13 | 100425078 | + |
intron-3CDS | ENST00000463709 | ENST00000444838 | TM9SF2 | chr13 | 100201476 | + | CLYBL | chr13 | 100425078 | + |
intron-3CDS | ENST00000463709 | ENST00000376360 | TM9SF2 | chr13 | 100201476 | + | CLYBL | chr13 | 100425078 | + |
intron-3CDS | ENST00000463709 | ENST00000376354 | TM9SF2 | chr13 | 100201476 | + | CLYBL | chr13 | 100425078 | + |
intron-3CDS | ENST00000463709 | ENST00000339105 | TM9SF2 | chr13 | 100201476 | + | CLYBL | chr13 | 100425078 | + |
Frame-shift | ENST00000376387 | ENST00000376355 | TM9SF2 | chr13 | 100204580 | + | CLYBL | chr13 | 100425078 | + |
Frame-shift | ENST00000376387 | ENST00000444838 | TM9SF2 | chr13 | 100204580 | + | CLYBL | chr13 | 100425078 | + |
Frame-shift | ENST00000376387 | ENST00000376360 | TM9SF2 | chr13 | 100204580 | + | CLYBL | chr13 | 100425078 | + |
Frame-shift | ENST00000376387 | ENST00000376354 | TM9SF2 | chr13 | 100204580 | + | CLYBL | chr13 | 100425078 | + |
Frame-shift | ENST00000376387 | ENST00000339105 | TM9SF2 | chr13 | 100204580 | + | CLYBL | chr13 | 100425078 | + |
intron-3CDS | ENST00000463709 | ENST00000376355 | TM9SF2 | chr13 | 100204580 | + | CLYBL | chr13 | 100425078 | + |
intron-3CDS | ENST00000463709 | ENST00000444838 | TM9SF2 | chr13 | 100204580 | + | CLYBL | chr13 | 100425078 | + |
intron-3CDS | ENST00000463709 | ENST00000376360 | TM9SF2 | chr13 | 100204580 | + | CLYBL | chr13 | 100425078 | + |
intron-3CDS | ENST00000463709 | ENST00000376354 | TM9SF2 | chr13 | 100204580 | + | CLYBL | chr13 | 100425078 | + |
intron-3CDS | ENST00000463709 | ENST00000339105 | TM9SF2 | chr13 | 100204580 | + | CLYBL | chr13 | 100425078 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000376387 | TM9SF2 | chr13 | 100201476 | + | ENST00000376355 | CLYBL | chr13 | 100425078 | + | 7092 | 1518 | 190 | 2376 | 728 |
ENST00000376387 | TM9SF2 | chr13 | 100201476 | + | ENST00000444838 | CLYBL | chr13 | 100425078 | + | 2877 | 1518 | 190 | 2364 | 724 |
ENST00000376387 | TM9SF2 | chr13 | 100201476 | + | ENST00000376360 | CLYBL | chr13 | 100425078 | + | 3636 | 1518 | 190 | 2478 | 762 |
ENST00000376387 | TM9SF2 | chr13 | 100201476 | + | ENST00000376354 | CLYBL | chr13 | 100425078 | + | 2577 | 1518 | 190 | 2376 | 728 |
ENST00000376387 | TM9SF2 | chr13 | 100201476 | + | ENST00000339105 | CLYBL | chr13 | 100425078 | + | 2625 | 1518 | 190 | 2478 | 762 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000376387 | ENST00000376355 | TM9SF2 | chr13 | 100201476 | + | CLYBL | chr13 | 100425078 | + | 0.000265457 | 0.9997346 |
ENST00000376387 | ENST00000444838 | TM9SF2 | chr13 | 100201476 | + | CLYBL | chr13 | 100425078 | + | 0.000207063 | 0.999793 |
ENST00000376387 | ENST00000376360 | TM9SF2 | chr13 | 100201476 | + | CLYBL | chr13 | 100425078 | + | 0.000122686 | 0.99987733 |
ENST00000376387 | ENST00000376354 | TM9SF2 | chr13 | 100201476 | + | CLYBL | chr13 | 100425078 | + | 0.00019122 | 0.99980885 |
ENST00000376387 | ENST00000339105 | TM9SF2 | chr13 | 100201476 | + | CLYBL | chr13 | 100425078 | + | 0.000252131 | 0.9997478 |
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Fusion Genomic Features for TM9SF2-CLYBL |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
TM9SF2 | chr13 | 100201476 | + | CLYBL | chr13 | 100425077 | + | 3.76E-06 | 0.9999962 |
TM9SF2 | chr13 | 100204580 | + | CLYBL | chr13 | 100425077 | + | 2.84E-06 | 0.99999714 |
TM9SF2 | chr13 | 100201476 | + | CLYBL | chr13 | 100425077 | + | 3.76E-06 | 0.9999962 |
TM9SF2 | chr13 | 100204580 | + | CLYBL | chr13 | 100425077 | + | 2.84E-06 | 0.99999714 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for TM9SF2-CLYBL |
Go to FGviewer for the breakpoints of chr13:100201476-chr13:100425078 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | CLYBL |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism (PubMed:29056341). Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate (PubMed:29056341, PubMed:24334609). Also displays malyl-CoA thioesterase activity (PubMed:29056341). Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate (PubMed:24334609, PubMed:29056341). Also has very weak citramalate synthase activity in vitro (PubMed:24334609, PubMed:29056341). {ECO:0000269|PubMed:24334609, ECO:0000269|PubMed:29056341}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TM9SF2 | chr13:100201476 | chr13:100425078 | ENST00000376387 | + | 12 | 17 | 29_300 | 442.6666666666667 | 664.0 | Topological domain | Lumenal |
Hgene | TM9SF2 | chr13:100201476 | chr13:100425078 | ENST00000376387 | + | 12 | 17 | 322_374 | 442.6666666666667 | 664.0 | Topological domain | Cytoplasmic |
Hgene | TM9SF2 | chr13:100201476 | chr13:100425078 | ENST00000376387 | + | 12 | 17 | 396_398 | 442.6666666666667 | 664.0 | Topological domain | Lumenal |
Hgene | TM9SF2 | chr13:100201476 | chr13:100425078 | ENST00000376387 | + | 12 | 17 | 420_437 | 442.6666666666667 | 664.0 | Topological domain | Cytoplasmic |
Hgene | TM9SF2 | chr13:100201476 | chr13:100425078 | ENST00000376387 | + | 12 | 17 | 301_321 | 442.6666666666667 | 664.0 | Transmembrane | Helical |
Hgene | TM9SF2 | chr13:100201476 | chr13:100425078 | ENST00000376387 | + | 12 | 17 | 375_395 | 442.6666666666667 | 664.0 | Transmembrane | Helical |
Hgene | TM9SF2 | chr13:100201476 | chr13:100425078 | ENST00000376387 | + | 12 | 17 | 399_419 | 442.6666666666667 | 664.0 | Transmembrane | Helical |
Tgene | CLYBL | chr13:100201476 | chr13:100425078 | ENST00000339105 | 0 | 9 | 272_273 | 20.666666666666668 | 361.0 | Region | Substrate binding | |
Tgene | CLYBL | chr13:100201476 | chr13:100425078 | ENST00000376354 | 0 | 7 | 272_273 | 20.666666666666668 | 307.0 | Region | Substrate binding | |
Tgene | CLYBL | chr13:100201476 | chr13:100425078 | ENST00000376355 | 0 | 8 | 272_273 | 20.666666666666668 | 1839.6666666666667 | Region | Substrate binding | |
Tgene | CLYBL | chr13:100201476 | chr13:100425078 | ENST00000376360 | 0 | 8 | 272_273 | 20.666666666666668 | 341.0 | Region | Substrate binding |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TM9SF2 | chr13:100201476 | chr13:100425078 | ENST00000376387 | + | 12 | 17 | 459_466 | 442.6666666666667 | 664.0 | Topological domain | Lumenal |
Hgene | TM9SF2 | chr13:100201476 | chr13:100425078 | ENST00000376387 | + | 12 | 17 | 488_522 | 442.6666666666667 | 664.0 | Topological domain | Cytoplasmic |
Hgene | TM9SF2 | chr13:100201476 | chr13:100425078 | ENST00000376387 | + | 12 | 17 | 544_554 | 442.6666666666667 | 664.0 | Topological domain | Lumenal |
Hgene | TM9SF2 | chr13:100201476 | chr13:100425078 | ENST00000376387 | + | 12 | 17 | 576_591 | 442.6666666666667 | 664.0 | Topological domain | Cytoplasmic |
Hgene | TM9SF2 | chr13:100201476 | chr13:100425078 | ENST00000376387 | + | 12 | 17 | 613_631 | 442.6666666666667 | 664.0 | Topological domain | Lumenal |
Hgene | TM9SF2 | chr13:100201476 | chr13:100425078 | ENST00000376387 | + | 12 | 17 | 653_663 | 442.6666666666667 | 664.0 | Topological domain | Cytoplasmic |
Hgene | TM9SF2 | chr13:100201476 | chr13:100425078 | ENST00000376387 | + | 12 | 17 | 438_458 | 442.6666666666667 | 664.0 | Transmembrane | Helical |
Hgene | TM9SF2 | chr13:100201476 | chr13:100425078 | ENST00000376387 | + | 12 | 17 | 467_487 | 442.6666666666667 | 664.0 | Transmembrane | Helical |
Hgene | TM9SF2 | chr13:100201476 | chr13:100425078 | ENST00000376387 | + | 12 | 17 | 523_543 | 442.6666666666667 | 664.0 | Transmembrane | Helical |
Hgene | TM9SF2 | chr13:100201476 | chr13:100425078 | ENST00000376387 | + | 12 | 17 | 555_575 | 442.6666666666667 | 664.0 | Transmembrane | Helical |
Hgene | TM9SF2 | chr13:100201476 | chr13:100425078 | ENST00000376387 | + | 12 | 17 | 592_612 | 442.6666666666667 | 664.0 | Transmembrane | Helical |
Hgene | TM9SF2 | chr13:100201476 | chr13:100425078 | ENST00000376387 | + | 12 | 17 | 632_652 | 442.6666666666667 | 664.0 | Transmembrane | Helical |
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Fusion Gene Sequence for TM9SF2-CLYBL |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000376387_ENST00000376355_TCGA-A7-A4SC-01A_TM9SF2_chr13_100201476_+_CLYBL_chr13_100425078_length(transcript)=7092nt_BP=1518nt GCATGCTCTGTTGCGGTCCGCTTCGGTTTCTGTTGCGGGACCCGGGGTGTCTCCTAGCGCAACCGGAACTAGCCTTCTGGGGGCCGGCTT CCTTTATCTCTGGCGGCCTTGTAGTCGTCTCCGAGACTCCCCACCCCTCCTTCCCTCTTGACCCCCTAGGTTTGATTGCCCTTTCCCCGA AACAACTATCATGAGCGCGAGGCTGCCGGTGTTGTCTCCACCTCGGTGGCCGCGGCTGTTGCTGCTGTCGCTGCTCCTGCTGGGGGCGGT TCCTGGCCCGCGCCGGAGCGGCGCTTTCTACCTGCCCGGCCTGGCGCCCGTCAACTTCTGCGACGAAGAAAAAAAGAGCGACGAGTGCAA GGCCGAAATAGAACTATTTGTGAACAGACTTGATTCAGTGGAATCAGTTCTTCCTTATGAATACACAGCGTTTGATTTTTGCCAAGCATC AGAAGGAAAGCGCCCATCTGAAAATCTTGGTCAGGTACTATTCGGGGAAAGAATTGAACCTTCACCATATAAGTTTACGTTTAATAAGAA GGAGACCTGTAAGCTTGTTTGTACAAAAACATACCATACAGAGAAAGCTGAAGACAAACAAAAGTTAGAATTCTTGAAAAAAAGCATGTT ATTGAATTATCAACATCACTGGATTGTGGATAATATGCCTGTAACGTGGTGTTACGATGTTGAAGATGGTCAGAGGTTCTGTAATCCTGG ATTTCCTATTGGCTGTTACATTACAGATAAAGGCCATGCAAAAGATGCCTGTGTTATTAGTTCAGATTTCCATGAAAGAGATACATTTTA CATCTTCAACCATGTTGACATCAAAATATACTATCATGTTGTTGAAACTGGGTCCATGGGAGCAAGATTAGTGGCTGCTAAACTTGAACC GAAAAGCTTCAAACATACCCATATAGATAAACCAGACTGCTCAGGGCCCCCCATGGACATAAGTAACAAGGCTTCTGGGGAGATAAAAAT TGCCTATACTTACTCTGTTAGCTTCGAGGAAGATGATAAGATCAGATGGGCGTCTAGATGGGACTATATTCTGGAGTCTATGCCTCATAC CCACATTCAGTGGTTTAGCATTATGAATTCCCTGGTCATTGTTCTCTTCTTATCTGGAATGGTAGCTATGATTATGTTACGGACACTGCA CAAAGATATTGCTAGATATAATCAGATGGACTCTACGGAAGATGCCCAGGAAGAATTTGGCTGGAAACTTGTTCATGGTGATATATTCCG TCCTCCAAGAAAAGGGATGCTGCTATCAGTCTTTCTAGGATCCGGGACACAGATTTTAATTATGACCTTTGTGACTCTATTTTTCGCTTG CCTGGGATTTTTGTCACCTGCCAACCGAGGAGCGCTGATGACGTGTGCTGTGGTCCTGTGGGTGCTGCTGGGCACCCCTGCAGGCTATGT TGCTGCCAGATTCTATAAGTCCTTTGGAGGTGAGAAGTGGAAAACAAATGTTTTATTAACATCATTTCTTTGTCCTGGGAAAGCGTCTCT AGCAGCTGATATCCCCAGACTTGGATATAGTTCCTCATCCCATCACAAGTACATCCCCCGGAGGGCAGTGCTTTATGTACCTGGAAATGA TGAAAAGAAAATAAAGAAGATTCCATCCCTGAATGTAGATTGTGCAGTGCTCGACTGTGAGGATGGAGTGGCTGCAAACAAAAAGAATGA AGCTCGACTGAGAATTGTAAAAACTCTTGAAGACATTGATCTGGGCCCTACTGAAAAATGTGTGAGAGTCAACTCAGTTTCCAGTGGTCT GGCGGAAGAAGACCTAGAGACCCTTTTGCAATCCCGGGTCCTTCCTTCCAGCCTGATGCTACCAAAGGTGGAAAGTCCTGAAGAAATCCA GTGGGCAGTGTGTGAAGAAACCCTGAAGGTCGGGCCTCAAGTAGGTCTCTTTCTAGATGCAGTCGTTTTTGGAGGAGAAGACTTTCGAGC CAGCATAGGTGCAACAAGTAGTAAAGAAACCCTGGATATTCTCTACGCCCGGCAAAAGATTGTTGTCATAGCGAAAGCCTTTGGTCTCCA AGCCATAGATCTGGTGTACATTGACTTTCGAGATGGAGCTGGGCTGCTTAGACAGTCACGAGAAGGAGCCGCCATGGGCTTCACTGGTAA GCAGGTGATTCACCCTAACCAAATTGCCGTGGTCCAGGAGCAGTTTTCTCCTTCCCCTGAAAAAATTAAGTGGGCTGAAGAACTGATTGC TGCCTTTAAAGAACATCAACAATTAGGAAAGGGGGCCTTTACTTTCCAAGGGAGTATGATCGACATGCCATTACTGAAGCAGGCCCAGAA CACTGTTACGCTTGCCACCTCCATCAAGGAAAAATGATCTGTTAAATGAAGCTGTCATCAGGCTAAAGGGTATTGAAGCTGCAGAGGGAT CAACTTGTGCTTGCCAGAGGACGCCAATGAAGTTTGAAACACCAACAATCAGAGATTTTGTTTCTGTTCCTCATTAAATCATGAGCTTTT GTGCCGAGACTCTGGACGACTGTTCCTTAAGAAATTAACAGAATGGGAAGTTTTAAACTCTACACCAACCTTTTCATGACCTACACAGCA GCAACGCTGCTACTCTTAGACAAACACCGCGGGGAAGGCTGTTCTGTTTATTTAAATTTGTAAATAGAAAACAGTTGTTTTTTACTTTCA TTTTTCACCTCCTCCTACGCCCTTTTGGATTATTTCCTCTGCGGCCCCTAGCATGAGCCCCAACCAGGCCTCCCCTTTTCCCCACTTCTC TCAATTCCCACAGGAAGCCCGAGAGGTGAGGAGCTGAGGTTAGACACCAGGAGAGGCACCATCACACAAAAGCGCGGCCGCAGAGTCCCA CCGCCACCAGGCGACCCCCACCCAGAGAGGGACAGACATGCGGGGAGCCAGCACCGGGCAAGATGGCTCTGGGGATCCTCATTCTGTGAA GACACCAACTCATTTCTCAAACACAGGATCCAGGAGACAGATAGCTCCTAAATGGAGATGGCACATGCTCCGTGGGGTCCCTCATAGAGG AGTGCCACCCTCCACACTGGCCACGCTGGGCTGCCCCAGAGCGGCCAGAAAGGAAGGTGGGAGCTAGCCCCATCCTCACTCAGAGGCCGG AAGGAGGAAGATGGCATCTCGCCAACTTCAGAGCCGAATGGCCTCTAGCCACACTGCTTCCAGACCCCAGACGGGGCAGCAGCAGCAGTT CCCAGAGGAGCACCCATTGTTGCAGCTAGGACCCACCAAGGATGGGACTCCTGGAGTCAGGTGCACACCAGGTAACCCAGGACCACGCTG TGCACCCCCAGTCTGCCCCTCTGCTCAGAACACAGAGGGATGGGAGGATGGCTTGGCAGTGGGAAGGCAAAAGAAGGCCTCTCTCACTCT GCCCCTGCCATACGCACCCGCTGAGGGTGTTAGAAGCAGTGGAGGCAGAGCTGGCCCTAAGCAAAAGAAGAAAATAAACCTCACCTTGTC CTTCCTATGGGCAGCCCTCACCCCAATCTAACTAACCTTCCCATCCTCCAGCCTAATCCAAAGAAGCCCTTGGCTTGAGGGGATGAAGGG CTTGCGTTCTAGTCTCCACCCCAGCCCCACAGGCAGCCAGCCAGCCAGCCCCACACAGAGGGGCCTCCTCAAGGCCTCACTGGGAGCCTC CTGTCCCCAGCCAAGGAGCCCTACAGACCTGGGGAAAAGCAGGCCCCTCCGCAAGGCCCCTGGGTGGTGCGGAGGCCGGACCGGCTAGGC CTCCCGCTGCTGGCCACTCCCAGGCCACGGGTTCCTAGGTCCCAACCACATTGGACTGCTCGCCACGCCACTGCCCTCATCCCAAACTGC TTTGTTCAAACAAAACCACCTTGTTTCAGTCTCCCCAAATGTCCAGTTCATTATCTTCCTCATAACCCATGGTCCCTATTAGGGTAGGAT CATGAGACTAAGACCTATGAGAGCCACAAATCTGGACCAAAGTCCCATTCCCTGAACAGAGACCCAAACGACGAGGGTCCCAGAAGAGAG TTCAGTCCTGATCAGAAACCCATGGTGCCTTAGTCCTTGAAGAACAAAACTCTAGGAAGAAGATGCTGGAAGGCAAAGGGTATTCCCCCT CTTTCCCCACCCGCGTCTCTGTGGTGCCATGGGTGGGCCCAGGTACCCTGGGAAAGGTGGGAGAGCAGTCAAGGGTGGGTGTGTGATCTC CACTGGGCTCACTGGGCACCCCCGACACGGGGAAGTGAGAGCTGCCCGACTCCTGAGCCAGGCGTGGGTGACAGGAAGAGGACCTTGCAG CTAATCTGATTCATTAGAAACCATACCTGTTTATGTTTTGTGTAGCTCATCACAAGCCGCTTAGCCATATCACCCCCGTTATTAATTCTT GGGGTCTAAATTATGGGTAACACTATTAAAACATTATCAGAACTAATGAGAAACAATTACTTAGAAAATGAGCCGGGACAAGACTGAGTT GGGAACATCAGTGGTGATCACTGTAGATTAGTTTAATAAATCATCAGGTGCAAGGCAAGACTGACTGTATGTATGCAAAGCCCCGTCACG GGAAAATGAAATTGAGATTTTTTTTTTTTGCATAATTTTTTCATTAATCTCAATAGGACCCGTGTGGTGTAGATTGCTTTATTCCCCTAA TACCTTGCCTGAGGCGGGGGGGGGGGGGGGTGCCCAATAATGTCTTCATTGTTTTACTGAGGTCTTAATGACAATCTGTGACAACCTCAT TTTAATGTATAGAGGATTATATCAATACAGTCATGTTTTATTGAAATGGTGAAGGGAACTCCAGTCAGAGTCAGGCAGTGTCTGTGAGCA CAAGTTAGGAAGTTTCTCGGCATCCGGGAGCGTTCCCGTCTGATGTCCCAGTGTTAGTCCTCCCGGCCGCCCTCCCCTCCTCTCCTCCAG GGACGGCTGGGAAAACAGTCCTGCGGGATGAAGACTTCACCGCCTCCGATTTGAATTTGAAAGTAACTCCTTCCGTGGCATATTTCGCTG GGCAGATAGAACAAACCATGTCGTTTTCCCCCGTCTCTAAAATAGACATATTATTATCATTCACACTTTTGCACCCGGTCGTTTTGCGGG AGTTCGGGAAACTGACTTTCTTCATTGGGGACATTGTAATTTTCTGATGATGCCACGAGGAGAAAAAAAATACGGGTTTGTTTTAATTGG AAGGACCTTCCGCTTTTATGATTTCGGTTTACCTTGGAAAACTGAATCTTCTGTGTTTTATTTCTTTCCTCTAGTACTAGAAAAGCAATG AATTAATTGCACAAAACAGGTTCTGAGACGGCCCGCAGGCCCCGAGCTCGTGGACGCGGCCGAGGGTCGGGTGTGACCCGCGGAGCCGCT GCCAGGCTTCCCAGCTCGTCTTCGCGGGGAGGCGGGAGGCAGGACCAGACCCCAGCATTTCAGCGTGAAAGTCTTCGCCTTTCTTTCCGC GCTGTCTTTCCCGCGGGCGGAGCGGCGTACCTGAGCGCGGTCCCCACGGAGGATCAGTGACTTTCCCAGACCCCGCGGGCGAGCCCGCGC TTGGGACCCGGCAGCTCTGCGCGGGCTGGTTTTGGAGGGGGTGGTGTTCGTTTGTTTAAATTCCAGTTGTTATTTGGCAGCATATCGCCT TCCGAGTCAGTAAGAATTGCCCACGACGTAAAGAGCGACTTGCAGGAAGGGGCCGAAGCCGTCGTTAGCGCCCGGGCGGCGGCGGCCACT CGAACCCCGTTTCCGCCAAGCGCGCTGCAACCTGCGGGGCGAGTTCGTTTTGTTTTGCCAAAATCATTTGGGGACTTCTTTGTCATTCAT GCCCTTCCTTTTAAATGATTTTTATTTTTTTCCACTGTAAGTGACCGGCTGGGTTTGACTTTTGCTTCTTCCGACGGAAGGGCACCGCGA GCCGGGGTGGGCGGCCCCGCGGGCAGGAGGAGCGCGGGGTACACGCGGTGGCCGCAGACGCCGAGCCCTGCGGAGCCCCGAGGCCTCGTC GCCCGCGCCCCCGGTGCGCGCGGAGCCGGGGCCGAGGCCGGGCCAGGAGGAGTGTGGCGGCCCAGGAGGCCTGGACTGTGGGCCCTGCTC GCCCGCCCGCCGCGGGCCGCCCGGAGCCCGCGCGCCTGTCGCGCAGCCCGGCTGTAATGGTGGCAGATCAAAGGCGGCCCCGTGTCCCCG CGGAGCCCGGGACAATCCCGCGCCTTTGTGCGCTGTTGCTAGGAGCCCGAGAAACTAAGAGAAAGTGTCAGGAGCATGTTAATCAGACTC GTTACACTGTAACAATAACGTCTCTCTCGGGTCTCCCAGGCCCCAGTACCCCCGCGCACCCTGCGCGCAGGCCGGACACCTGCGCAGGGC CCTTGCGCCCGCCCTGGGGTCCCGCCGGCCCTGGGGTCCCTGCAGCCCCGAATCCGCACCCGAGCCACGCGGAACGACTAGCCCCGAGGG GCCCCGCAGGCTCCCGGTGCAGCTCCCTGGTCGTGGTCTCCTTGACCGAAGCCCCGGCCTCACACCGCCTGGCCGCGAGCCCGAGGGACG CAGGGACGATCCCGGTCCCCTGCTTTTCAGTCCTCCAGTCGAATCGCCCACTTTGTTCAATCACAGTATTCGAATCAAGAGGAAAATGAA CATTCCCTTTATGGTAGCTTTTTGGTTATGAGTTTTGGCAAAACTGTTAAATCAACTTTGCCGATTTCCCTTGGGAATCCCTGGAGGCCA CTCTAAGTGGTAATCCCAAGTTTAAGAAGGAAATGGGGAAATTTTGCTGAGAGTAAAGATGTCGCCGAACTTTTTGAAGGGATTTGCTTC ATTCATTCATTTAGTCATTCAACAGACACCTGTTGAACCCGACTGGGTGCCAGAGGGGCCAGTCACAGGACTTATTCCAGATGAACTTTT CTTTTGAAATTAGAATGCCCTTGTGGAAGCCAAAGGAGGAGCAGAGGCCTAAAATAATGTCAAGTGTCAAAGCAAAAAGAAGTGCCATTG >In-frame_ENST00000376387_ENST00000376355_TCGA-A7-A4SC-01A_TM9SF2_chr13_100201476_+_CLYBL_chr13_100425078_length(amino acids)=728AA_start in transcript=190_stop in transcript=2376 MSARLPVLSPPRWPRLLLLSLLLLGAVPGPRRSGAFYLPGLAPVNFCDEEKKSDECKAEIELFVNRLDSVESVLPYEYTAFDFCQASEGK RPSENLGQVLFGERIEPSPYKFTFNKKETCKLVCTKTYHTEKAEDKQKLEFLKKSMLLNYQHHWIVDNMPVTWCYDVEDGQRFCNPGFPI GCYITDKGHAKDACVISSDFHERDTFYIFNHVDIKIYYHVVETGSMGARLVAAKLEPKSFKHTHIDKPDCSGPPMDISNKASGEIKIAYT YSVSFEEDDKIRWASRWDYILESMPHTHIQWFSIMNSLVIVLFLSGMVAMIMLRTLHKDIARYNQMDSTEDAQEEFGWKLVHGDIFRPPR KGMLLSVFLGSGTQILIMTFVTLFFACLGFLSPANRGALMTCAVVLWVLLGTPAGYVAARFYKSFGGEKWKTNVLLTSFLCPGKASLAAD IPRLGYSSSSHHKYIPRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKNEARLRIVKTLEDIDLGPTEKCVRVNSVSSGLAEE DLETLLQSRVLPSSLMLPKVESPEEIQWAVCEETLKVGPQVGLFLDAVVFGGEDFRASIGATSSKETLDILYARQKIVVIAKAFGLQAID LVYIDFRDGAGLLRQSREGAAMGFTGKQVIHPNQIAVVQEQFSPSPEKIKWAEELIAAFKEHQQLGKGAFTFQGSMIDMPLLKQAQNTVT -------------------------------------------------------------- >In-frame_ENST00000376387_ENST00000444838_TCGA-A7-A4SC-01A_TM9SF2_chr13_100201476_+_CLYBL_chr13_100425078_length(transcript)=2877nt_BP=1518nt GCATGCTCTGTTGCGGTCCGCTTCGGTTTCTGTTGCGGGACCCGGGGTGTCTCCTAGCGCAACCGGAACTAGCCTTCTGGGGGCCGGCTT CCTTTATCTCTGGCGGCCTTGTAGTCGTCTCCGAGACTCCCCACCCCTCCTTCCCTCTTGACCCCCTAGGTTTGATTGCCCTTTCCCCGA AACAACTATCATGAGCGCGAGGCTGCCGGTGTTGTCTCCACCTCGGTGGCCGCGGCTGTTGCTGCTGTCGCTGCTCCTGCTGGGGGCGGT TCCTGGCCCGCGCCGGAGCGGCGCTTTCTACCTGCCCGGCCTGGCGCCCGTCAACTTCTGCGACGAAGAAAAAAAGAGCGACGAGTGCAA GGCCGAAATAGAACTATTTGTGAACAGACTTGATTCAGTGGAATCAGTTCTTCCTTATGAATACACAGCGTTTGATTTTTGCCAAGCATC AGAAGGAAAGCGCCCATCTGAAAATCTTGGTCAGGTACTATTCGGGGAAAGAATTGAACCTTCACCATATAAGTTTACGTTTAATAAGAA GGAGACCTGTAAGCTTGTTTGTACAAAAACATACCATACAGAGAAAGCTGAAGACAAACAAAAGTTAGAATTCTTGAAAAAAAGCATGTT ATTGAATTATCAACATCACTGGATTGTGGATAATATGCCTGTAACGTGGTGTTACGATGTTGAAGATGGTCAGAGGTTCTGTAATCCTGG ATTTCCTATTGGCTGTTACATTACAGATAAAGGCCATGCAAAAGATGCCTGTGTTATTAGTTCAGATTTCCATGAAAGAGATACATTTTA CATCTTCAACCATGTTGACATCAAAATATACTATCATGTTGTTGAAACTGGGTCCATGGGAGCAAGATTAGTGGCTGCTAAACTTGAACC GAAAAGCTTCAAACATACCCATATAGATAAACCAGACTGCTCAGGGCCCCCCATGGACATAAGTAACAAGGCTTCTGGGGAGATAAAAAT TGCCTATACTTACTCTGTTAGCTTCGAGGAAGATGATAAGATCAGATGGGCGTCTAGATGGGACTATATTCTGGAGTCTATGCCTCATAC CCACATTCAGTGGTTTAGCATTATGAATTCCCTGGTCATTGTTCTCTTCTTATCTGGAATGGTAGCTATGATTATGTTACGGACACTGCA CAAAGATATTGCTAGATATAATCAGATGGACTCTACGGAAGATGCCCAGGAAGAATTTGGCTGGAAACTTGTTCATGGTGATATATTCCG TCCTCCAAGAAAAGGGATGCTGCTATCAGTCTTTCTAGGATCCGGGACACAGATTTTAATTATGACCTTTGTGACTCTATTTTTCGCTTG CCTGGGATTTTTGTCACCTGCCAACCGAGGAGCGCTGATGACGTGTGCTGTGGTCCTGTGGGTGCTGCTGGGCACCCCTGCAGGCTATGT TGCTGCCAGATTCTATAAGTCCTTTGGAGGTGAGAAGTGGAAAACAAATGTTTTATTAACATCATTTCTTTGTCCTGGGAAAGCGTCTCT AGCAGCTGATATCCCCAGACTTGGATATAGTTCCTCATCCCATCACAAGTACATCCCCCGGAGGGCAGTGCTTTATGTACCTGGAAATGA TGAAAAGAAAATAAAGAAGATTCCATCCCTGAATGTAGATTGTGCAGTGCTCGACTGTGAGGATGGAGTGGCTGCAAACAAAAAGAATGA AGCTCGACTGAGAATTGTAAAAACTCTTGAAGACATTGATCTGGGCCCTACTGAAAAATGTGTGAGAGTCAACTCAGTTTCCAGTGGTCT GGCGGAAGAAGACCTAGAGACCCTTTTGCAATCCCGGGTCCTTCCTTCCAGCCTGATGCTACCAAAGGTGGAAAGTCCTGAAGAAATCCA GTGGGCAGTGTGTGAAGAAACCCTGAAGGTCGGGCCTCAAGTAGGTCTCTTTCTAGATGCAGTCGTTTTTGGAGGAGAAGACTTTCGAGC CAGCATAGGTGCAACAAGTAGTAAAGAAACCCTGGATATTCTCTACGCCCGGCAAAAGATTGTTGTCATAGCGAAAGCCTTTGGTCTCCA AGCCATAGATCTGGTGTACATTGACTTTCGAGATGGAGCTGGGCTGCTTAGACAGTCACGAGAAGGAGCCGCCATGGGCTTCACTGGTAA GCAGGTGATTCACCCTAACCAAATTGCCGTGGTCCAGGAGCAGTTTTCTCCTTCCCCTGAAAAAATTAAGTGGGCTGAAGAACTGATTGC TGCCTTTAAAGAACATCAACAATTAGGAAAGACAGTGTCTTGCTCTGCCAGCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTCCCTGCA ACCTCCGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTAGGATTACAGGCGCACAACATGCCTGGCTAATTTTTG TATTTTTAGTAGAGACGGTGTTTCACCATTTTGGTCAGGCTGGTCTCAAACTCCTGACCTCATGATCTGCCCACCTCCGCCTCCCAAAGT GCTGGGATTACAGGCGTAAGCCACCGCGCCCAGCCCAGAATTTTGTAGTTCTTTTTATACTGAATTTTATTAAAAATACAAAGCAACCAT TTCTATAATTGTCTTTTTTTTCCCCCACTTTAGGTCAGTGGGCCTCAAAAAAAAAGTGAGGCAATTTCTTACCACTACCTTAGGGAATAA AGAATTCTCTCTACCGTAGCACGCACCTCCCTGCAGCATCTTGGGCAGAAATAGGTACACGAAACACATTTAGTAAACATTATTTAGCTA >In-frame_ENST00000376387_ENST00000444838_TCGA-A7-A4SC-01A_TM9SF2_chr13_100201476_+_CLYBL_chr13_100425078_length(amino acids)=724AA_start in transcript=190_stop in transcript=2364 MSARLPVLSPPRWPRLLLLSLLLLGAVPGPRRSGAFYLPGLAPVNFCDEEKKSDECKAEIELFVNRLDSVESVLPYEYTAFDFCQASEGK RPSENLGQVLFGERIEPSPYKFTFNKKETCKLVCTKTYHTEKAEDKQKLEFLKKSMLLNYQHHWIVDNMPVTWCYDVEDGQRFCNPGFPI GCYITDKGHAKDACVISSDFHERDTFYIFNHVDIKIYYHVVETGSMGARLVAAKLEPKSFKHTHIDKPDCSGPPMDISNKASGEIKIAYT YSVSFEEDDKIRWASRWDYILESMPHTHIQWFSIMNSLVIVLFLSGMVAMIMLRTLHKDIARYNQMDSTEDAQEEFGWKLVHGDIFRPPR KGMLLSVFLGSGTQILIMTFVTLFFACLGFLSPANRGALMTCAVVLWVLLGTPAGYVAARFYKSFGGEKWKTNVLLTSFLCPGKASLAAD IPRLGYSSSSHHKYIPRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKNEARLRIVKTLEDIDLGPTEKCVRVNSVSSGLAEE DLETLLQSRVLPSSLMLPKVESPEEIQWAVCEETLKVGPQVGLFLDAVVFGGEDFRASIGATSSKETLDILYARQKIVVIAKAFGLQAID LVYIDFRDGAGLLRQSREGAAMGFTGKQVIHPNQIAVVQEQFSPSPEKIKWAEELIAAFKEHQQLGKTVSCSASQAGVQWRDLGSLQPPP -------------------------------------------------------------- >In-frame_ENST00000376387_ENST00000376360_TCGA-A7-A4SC-01A_TM9SF2_chr13_100201476_+_CLYBL_chr13_100425078_length(transcript)=3636nt_BP=1518nt GCATGCTCTGTTGCGGTCCGCTTCGGTTTCTGTTGCGGGACCCGGGGTGTCTCCTAGCGCAACCGGAACTAGCCTTCTGGGGGCCGGCTT CCTTTATCTCTGGCGGCCTTGTAGTCGTCTCCGAGACTCCCCACCCCTCCTTCCCTCTTGACCCCCTAGGTTTGATTGCCCTTTCCCCGA AACAACTATCATGAGCGCGAGGCTGCCGGTGTTGTCTCCACCTCGGTGGCCGCGGCTGTTGCTGCTGTCGCTGCTCCTGCTGGGGGCGGT TCCTGGCCCGCGCCGGAGCGGCGCTTTCTACCTGCCCGGCCTGGCGCCCGTCAACTTCTGCGACGAAGAAAAAAAGAGCGACGAGTGCAA GGCCGAAATAGAACTATTTGTGAACAGACTTGATTCAGTGGAATCAGTTCTTCCTTATGAATACACAGCGTTTGATTTTTGCCAAGCATC AGAAGGAAAGCGCCCATCTGAAAATCTTGGTCAGGTACTATTCGGGGAAAGAATTGAACCTTCACCATATAAGTTTACGTTTAATAAGAA GGAGACCTGTAAGCTTGTTTGTACAAAAACATACCATACAGAGAAAGCTGAAGACAAACAAAAGTTAGAATTCTTGAAAAAAAGCATGTT ATTGAATTATCAACATCACTGGATTGTGGATAATATGCCTGTAACGTGGTGTTACGATGTTGAAGATGGTCAGAGGTTCTGTAATCCTGG ATTTCCTATTGGCTGTTACATTACAGATAAAGGCCATGCAAAAGATGCCTGTGTTATTAGTTCAGATTTCCATGAAAGAGATACATTTTA CATCTTCAACCATGTTGACATCAAAATATACTATCATGTTGTTGAAACTGGGTCCATGGGAGCAAGATTAGTGGCTGCTAAACTTGAACC GAAAAGCTTCAAACATACCCATATAGATAAACCAGACTGCTCAGGGCCCCCCATGGACATAAGTAACAAGGCTTCTGGGGAGATAAAAAT TGCCTATACTTACTCTGTTAGCTTCGAGGAAGATGATAAGATCAGATGGGCGTCTAGATGGGACTATATTCTGGAGTCTATGCCTCATAC CCACATTCAGTGGTTTAGCATTATGAATTCCCTGGTCATTGTTCTCTTCTTATCTGGAATGGTAGCTATGATTATGTTACGGACACTGCA CAAAGATATTGCTAGATATAATCAGATGGACTCTACGGAAGATGCCCAGGAAGAATTTGGCTGGAAACTTGTTCATGGTGATATATTCCG TCCTCCAAGAAAAGGGATGCTGCTATCAGTCTTTCTAGGATCCGGGACACAGATTTTAATTATGACCTTTGTGACTCTATTTTTCGCTTG CCTGGGATTTTTGTCACCTGCCAACCGAGGAGCGCTGATGACGTGTGCTGTGGTCCTGTGGGTGCTGCTGGGCACCCCTGCAGGCTATGT TGCTGCCAGATTCTATAAGTCCTTTGGAGGTGAGAAGTGGAAAACAAATGTTTTATTAACATCATTTCTTTGTCCTGGGAAAGCGTCTCT AGCAGCTGATATCCCCAGACTTGGATATAGTTCCTCATCCCATCACAAGTACATCCCCCGGAGGGCAGTGCTTTATGTACCTGGAAATGA TGAAAAGAAAATAAAGAAGATTCCATCCCTGAATGTAGATTGTGCAGTGCTCGACTGTGAGGATGGAGTGGCTGCAAACAAAAAGAATGA AGCTCGACTGAGAATTGTAAAAACTCTTGAAGACATTGATCTGGGCCCTACTGAAAAATGTGTGAGAGTCAACTCAGTTTCCAGTGGTCT GGCGGAAGAAGACCTAGAGACCCTTTTGCAATCCCGGGTCCTTCCTTCCAGCCTGATGCTACCAAAGGTGGAAAGTCCTGAAGAAATCCA GTGGTTTGCAGACAAATTTTCATTCCACTTAAAAGGCCGAAAACTTGAACAACCAATGAATTTAATCCCTTTTGTGGAAACTGCAATGGG TTTGCTCAATTTTAAGGCAGTGTGTGAAGAAACCCTGAAGGTCGGGCCTCAAGTAGGTCTCTTTCTAGATGCAGTCGTTTTTGGAGGAGA AGACTTTCGAGCCAGCATAGGTGCAACAAGTAGTAAAGAAACCCTGGATATTCTCTACGCCCGGCAAAAGATTGTTGTCATAGCGAAAGC CTTTGGTCTCCAAGCCATAGATCTGGTGTACATTGACTTTCGAGATGGAGCTGGGCTGCTTAGACAGTCACGAGAAGGAGCCGCCATGGG CTTCACTGGTAAGCAGGTGATTCACCCTAACCAAATTGCCGTGGTCCAGGAGCAGTTTTCTCCTTCCCCTGAAAAAATTAAGTGGGCTGA AGAACTGATTGCTGCCTTTAAAGAACATCAACAATTAGGAAAGGGGGCCTTTACTTTCCAAGGGAGTATGATCGACATGCCATTACTGAA GCAGGCCCAGAACACTGTTACGCTTGCCACCTCCATCAAGGAAAAATGATCTGTTAAATGAAGCTGTCATCAGGTGGGCTGAACATATAC AGTGGGGTTCTTAAAGACAAACCACAATACTCAAAGCAACTTGTTAGGATGCCAGATTGGGACCTGACTCCATTTACAGTTCATGTTAAT CACAATTTTGTTGTTGTTGTCTCACTGGCCAGTTATTCCCCTAAAAAAATGAACGCTTTTCCCTTTGGATCCAAGCTTATGATTTTATCA TTTTTAGTGTATTACGAATATGGGCTTATGATTTCACAGGGAGGTAAGATCCTGGGGAAAGATGGGCTGTGAGGCGAAGGTAGGTCTTTA ATGAAATGGATCTTTCCCAAATAGACATATTCCCTCCACCCTTCTCATGTTAGTAAATGTTTCCTGCTTGTTCATTTATACAGCTGACAC CACAAATAATTTTAAGAAAAGCCAGGCCTTTAAAACATAGTAGCAACATTAAGGGGTCATCTCTATTTCACTAGTAATCTGATAAAACAA CAGAGATGGCATCAAAAAAGAATACTAAGTATTATATTGGCTTAAAAAGACACTTTCTGAAAATAAACTTTCGAAACTGGTTACTATTAA CCTCCACCCCTAAAACGAAACATCCATCTCCTTGAACCGCTAGACGATGAACACGAAAGCTGTCATCCTGGGTGAATGCTGTGAGTCAAC CATTACCGGCAATTAAAAAATAAATGTGCAGAAACACAAGACCATCCATTCTCCCCCTTTATTTTCCCGTTTAACTGTTTGCCATTGAGG CTATTTCCCCCTGGAAATGTATGGCTGGGACAGGACTCCCTCAGTCATAAACTTGTAGCGTCTCAGAAGACACAATGCACCCGAGCTGGT GCATGTGGCCCCTGCGAGATTTGCATCACATTAGAGATGCGGCTGCAGGTCAGATGGGTGGTGTGGTTAACGGGCTTAGTAAAGCTGTTT TGAAGAGGTTAACCCAGCTTGTAGTAAGGGTAAATAAACATAACAACCAGCCATTGTTCCCTATTCAGCATGTACTCTTATATTGAAGGC TAAAGGGTATTGAAGCTGCAGAGGGATCAACTTGTGCTTGCCAGAGGACGCCAATGAAGTTTGAAACACCAACAATCAGAGATTTTGTTT >In-frame_ENST00000376387_ENST00000376360_TCGA-A7-A4SC-01A_TM9SF2_chr13_100201476_+_CLYBL_chr13_100425078_length(amino acids)=762AA_start in transcript=190_stop in transcript=2478 MSARLPVLSPPRWPRLLLLSLLLLGAVPGPRRSGAFYLPGLAPVNFCDEEKKSDECKAEIELFVNRLDSVESVLPYEYTAFDFCQASEGK RPSENLGQVLFGERIEPSPYKFTFNKKETCKLVCTKTYHTEKAEDKQKLEFLKKSMLLNYQHHWIVDNMPVTWCYDVEDGQRFCNPGFPI GCYITDKGHAKDACVISSDFHERDTFYIFNHVDIKIYYHVVETGSMGARLVAAKLEPKSFKHTHIDKPDCSGPPMDISNKASGEIKIAYT YSVSFEEDDKIRWASRWDYILESMPHTHIQWFSIMNSLVIVLFLSGMVAMIMLRTLHKDIARYNQMDSTEDAQEEFGWKLVHGDIFRPPR KGMLLSVFLGSGTQILIMTFVTLFFACLGFLSPANRGALMTCAVVLWVLLGTPAGYVAARFYKSFGGEKWKTNVLLTSFLCPGKASLAAD IPRLGYSSSSHHKYIPRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKNEARLRIVKTLEDIDLGPTEKCVRVNSVSSGLAEE DLETLLQSRVLPSSLMLPKVESPEEIQWFADKFSFHLKGRKLEQPMNLIPFVETAMGLLNFKAVCEETLKVGPQVGLFLDAVVFGGEDFR ASIGATSSKETLDILYARQKIVVIAKAFGLQAIDLVYIDFRDGAGLLRQSREGAAMGFTGKQVIHPNQIAVVQEQFSPSPEKIKWAEELI -------------------------------------------------------------- >In-frame_ENST00000376387_ENST00000376354_TCGA-A7-A4SC-01A_TM9SF2_chr13_100201476_+_CLYBL_chr13_100425078_length(transcript)=2577nt_BP=1518nt GCATGCTCTGTTGCGGTCCGCTTCGGTTTCTGTTGCGGGACCCGGGGTGTCTCCTAGCGCAACCGGAACTAGCCTTCTGGGGGCCGGCTT CCTTTATCTCTGGCGGCCTTGTAGTCGTCTCCGAGACTCCCCACCCCTCCTTCCCTCTTGACCCCCTAGGTTTGATTGCCCTTTCCCCGA AACAACTATCATGAGCGCGAGGCTGCCGGTGTTGTCTCCACCTCGGTGGCCGCGGCTGTTGCTGCTGTCGCTGCTCCTGCTGGGGGCGGT TCCTGGCCCGCGCCGGAGCGGCGCTTTCTACCTGCCCGGCCTGGCGCCCGTCAACTTCTGCGACGAAGAAAAAAAGAGCGACGAGTGCAA GGCCGAAATAGAACTATTTGTGAACAGACTTGATTCAGTGGAATCAGTTCTTCCTTATGAATACACAGCGTTTGATTTTTGCCAAGCATC AGAAGGAAAGCGCCCATCTGAAAATCTTGGTCAGGTACTATTCGGGGAAAGAATTGAACCTTCACCATATAAGTTTACGTTTAATAAGAA GGAGACCTGTAAGCTTGTTTGTACAAAAACATACCATACAGAGAAAGCTGAAGACAAACAAAAGTTAGAATTCTTGAAAAAAAGCATGTT ATTGAATTATCAACATCACTGGATTGTGGATAATATGCCTGTAACGTGGTGTTACGATGTTGAAGATGGTCAGAGGTTCTGTAATCCTGG ATTTCCTATTGGCTGTTACATTACAGATAAAGGCCATGCAAAAGATGCCTGTGTTATTAGTTCAGATTTCCATGAAAGAGATACATTTTA CATCTTCAACCATGTTGACATCAAAATATACTATCATGTTGTTGAAACTGGGTCCATGGGAGCAAGATTAGTGGCTGCTAAACTTGAACC GAAAAGCTTCAAACATACCCATATAGATAAACCAGACTGCTCAGGGCCCCCCATGGACATAAGTAACAAGGCTTCTGGGGAGATAAAAAT TGCCTATACTTACTCTGTTAGCTTCGAGGAAGATGATAAGATCAGATGGGCGTCTAGATGGGACTATATTCTGGAGTCTATGCCTCATAC CCACATTCAGTGGTTTAGCATTATGAATTCCCTGGTCATTGTTCTCTTCTTATCTGGAATGGTAGCTATGATTATGTTACGGACACTGCA CAAAGATATTGCTAGATATAATCAGATGGACTCTACGGAAGATGCCCAGGAAGAATTTGGCTGGAAACTTGTTCATGGTGATATATTCCG TCCTCCAAGAAAAGGGATGCTGCTATCAGTCTTTCTAGGATCCGGGACACAGATTTTAATTATGACCTTTGTGACTCTATTTTTCGCTTG CCTGGGATTTTTGTCACCTGCCAACCGAGGAGCGCTGATGACGTGTGCTGTGGTCCTGTGGGTGCTGCTGGGCACCCCTGCAGGCTATGT TGCTGCCAGATTCTATAAGTCCTTTGGAGGTGAGAAGTGGAAAACAAATGTTTTATTAACATCATTTCTTTGTCCTGGGAAAGCGTCTCT AGCAGCTGATATCCCCAGACTTGGATATAGTTCCTCATCCCATCACAAGTACATCCCCCGGAGGGCAGTGCTTTATGTACCTGGAAATGA TGAAAAGAAAATAAAGAAGATTCCATCCCTGAATGTAGATTGTGCAGTGCTCGACTGTGAGGATGGAGTGGCTGCAAACAAAAAGAATGA AGCTCGACTGAGAATTGTAAAAACTCTTGAAGACATTGATCTGGGCCCTACTGAAAAATGTGTGAGAGTCAACTCAGTTTCCAGTGGTCT GGCGGAAGAAGACCTAGAGACCCTTTTGCAATCCCGGGTCCTTCCTTCCAGCCTGATGCTACCAAAGGTGGAAAGTCCTGAAGAAATCCA GTGGGCAGTGTGTGAAGAAACCCTGAAGGTCGGGCCTCAAGTAGGTCTCTTTCTAGATGCAGTCGTTTTTGGAGGAGAAGACTTTCGAGC CAGCATAGGTGCAACAAGTAGTAAAGAAACCCTGGATATTCTCTACGCCCGGCAAAAGATTGTTGTCATAGCGAAAGCCTTTGGTCTCCA AGCCATAGATCTGGTGTACATTGACTTTCGAGATGGAGCTGGGCTGCTTAGACAGTCACGAGAAGGAGCCGCCATGGGCTTCACTGGTAA GCAGGTGATTCACCCTAACCAAATTGCCGTGGTCCAGGAGCAGTTTTCTCCTTCCCCTGAAAAAATTAAGTGGGCTGAAGAACTGATTGC TGCCTTTAAAGAACATCAACAATTAGGAAAGGGGGCCTTTACTTTCCAAGGGAGTATGATCGACATGCCATTACTGAAGCAGGCCCAGAA CACTGTTACGCTTGCCACCTCCATCAAGGAAAAATGATCTGTTAAATGAAGCTGTCATCAGGTGGGCTGAACATATACAGTGGGGTTCTT AAAGACAAACCACAATACTCAAAGCAACTTGTTAGGATGCCAGATTGGGACCTGACTCCATTTACAGTTCATGTTAATCACAATTTTGTT >In-frame_ENST00000376387_ENST00000376354_TCGA-A7-A4SC-01A_TM9SF2_chr13_100201476_+_CLYBL_chr13_100425078_length(amino acids)=728AA_start in transcript=190_stop in transcript=2376 MSARLPVLSPPRWPRLLLLSLLLLGAVPGPRRSGAFYLPGLAPVNFCDEEKKSDECKAEIELFVNRLDSVESVLPYEYTAFDFCQASEGK RPSENLGQVLFGERIEPSPYKFTFNKKETCKLVCTKTYHTEKAEDKQKLEFLKKSMLLNYQHHWIVDNMPVTWCYDVEDGQRFCNPGFPI GCYITDKGHAKDACVISSDFHERDTFYIFNHVDIKIYYHVVETGSMGARLVAAKLEPKSFKHTHIDKPDCSGPPMDISNKASGEIKIAYT YSVSFEEDDKIRWASRWDYILESMPHTHIQWFSIMNSLVIVLFLSGMVAMIMLRTLHKDIARYNQMDSTEDAQEEFGWKLVHGDIFRPPR KGMLLSVFLGSGTQILIMTFVTLFFACLGFLSPANRGALMTCAVVLWVLLGTPAGYVAARFYKSFGGEKWKTNVLLTSFLCPGKASLAAD IPRLGYSSSSHHKYIPRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKNEARLRIVKTLEDIDLGPTEKCVRVNSVSSGLAEE DLETLLQSRVLPSSLMLPKVESPEEIQWAVCEETLKVGPQVGLFLDAVVFGGEDFRASIGATSSKETLDILYARQKIVVIAKAFGLQAID LVYIDFRDGAGLLRQSREGAAMGFTGKQVIHPNQIAVVQEQFSPSPEKIKWAEELIAAFKEHQQLGKGAFTFQGSMIDMPLLKQAQNTVT -------------------------------------------------------------- >In-frame_ENST00000376387_ENST00000339105_TCGA-A7-A4SC-01A_TM9SF2_chr13_100201476_+_CLYBL_chr13_100425078_length(transcript)=2625nt_BP=1518nt GCATGCTCTGTTGCGGTCCGCTTCGGTTTCTGTTGCGGGACCCGGGGTGTCTCCTAGCGCAACCGGAACTAGCCTTCTGGGGGCCGGCTT CCTTTATCTCTGGCGGCCTTGTAGTCGTCTCCGAGACTCCCCACCCCTCCTTCCCTCTTGACCCCCTAGGTTTGATTGCCCTTTCCCCGA AACAACTATCATGAGCGCGAGGCTGCCGGTGTTGTCTCCACCTCGGTGGCCGCGGCTGTTGCTGCTGTCGCTGCTCCTGCTGGGGGCGGT TCCTGGCCCGCGCCGGAGCGGCGCTTTCTACCTGCCCGGCCTGGCGCCCGTCAACTTCTGCGACGAAGAAAAAAAGAGCGACGAGTGCAA GGCCGAAATAGAACTATTTGTGAACAGACTTGATTCAGTGGAATCAGTTCTTCCTTATGAATACACAGCGTTTGATTTTTGCCAAGCATC AGAAGGAAAGCGCCCATCTGAAAATCTTGGTCAGGTACTATTCGGGGAAAGAATTGAACCTTCACCATATAAGTTTACGTTTAATAAGAA GGAGACCTGTAAGCTTGTTTGTACAAAAACATACCATACAGAGAAAGCTGAAGACAAACAAAAGTTAGAATTCTTGAAAAAAAGCATGTT ATTGAATTATCAACATCACTGGATTGTGGATAATATGCCTGTAACGTGGTGTTACGATGTTGAAGATGGTCAGAGGTTCTGTAATCCTGG ATTTCCTATTGGCTGTTACATTACAGATAAAGGCCATGCAAAAGATGCCTGTGTTATTAGTTCAGATTTCCATGAAAGAGATACATTTTA CATCTTCAACCATGTTGACATCAAAATATACTATCATGTTGTTGAAACTGGGTCCATGGGAGCAAGATTAGTGGCTGCTAAACTTGAACC GAAAAGCTTCAAACATACCCATATAGATAAACCAGACTGCTCAGGGCCCCCCATGGACATAAGTAACAAGGCTTCTGGGGAGATAAAAAT TGCCTATACTTACTCTGTTAGCTTCGAGGAAGATGATAAGATCAGATGGGCGTCTAGATGGGACTATATTCTGGAGTCTATGCCTCATAC CCACATTCAGTGGTTTAGCATTATGAATTCCCTGGTCATTGTTCTCTTCTTATCTGGAATGGTAGCTATGATTATGTTACGGACACTGCA CAAAGATATTGCTAGATATAATCAGATGGACTCTACGGAAGATGCCCAGGAAGAATTTGGCTGGAAACTTGTTCATGGTGATATATTCCG TCCTCCAAGAAAAGGGATGCTGCTATCAGTCTTTCTAGGATCCGGGACACAGATTTTAATTATGACCTTTGTGACTCTATTTTTCGCTTG CCTGGGATTTTTGTCACCTGCCAACCGAGGAGCGCTGATGACGTGTGCTGTGGTCCTGTGGGTGCTGCTGGGCACCCCTGCAGGCTATGT TGCTGCCAGATTCTATAAGTCCTTTGGAGGTGAGAAGTGGAAAACAAATGTTTTATTAACATCATTTCTTTGTCCTGGGAAAGCGTCTCT AGCAGCTGATATCCCCAGACTTGGATATAGTTCCTCATCCCATCACAAGTACATCCCCCGGAGGGCAGTGCTTTATGTACCTGGAAATGA TGAAAAGAAAATAAAGAAGATTCCATCCCTGAATGTAGATTGTGCAGTGCTCGACTGTGAGGATGGAGTGGCTGCAAACAAAAAGAATGA AGCTCGACTGAGAATTGTAAAAACTCTTGAAGACATTGATCTGGGCCCTACTGAAAAATGTGTGAGAGTCAACTCAGTTTCCAGTGGTCT GGCGGAAGAAGACCTAGAGACCCTTTTGCAATCCCGGGTCCTTCCTTCCAGCCTGATGCTACCAAAGGTGGAAAGTCCTGAAGAAATCCA GTGGTTTGCAGACAAATTTTCATTCCACTTAAAAGGCCGAAAACTTGAACAACCAATGAATTTAATCCCTTTTGTGGAAACTGCAATGGG TTTGCTCAATTTTAAGGCAGTGTGTGAAGAAACCCTGAAGGTCGGGCCTCAAGTAGGTCTCTTTCTAGATGCAGTCGTTTTTGGAGGAGA AGACTTTCGAGCCAGCATAGGTGCAACAAGTAGTAAAGAAACCCTGGATATTCTCTACGCCCGGCAAAAGATTGTTGTCATAGCGAAAGC CTTTGGTCTCCAAGCCATAGATCTGGTGTACATTGACTTTCGAGATGGAGCTGGGCTGCTTAGACAGTCACGAGAAGGAGCCGCCATGGG CTTCACTGGTAAGCAGGTGATTCACCCTAACCAAATTGCCGTGGTCCAGGAGCAGTTTTCTCCTTCCCCTGAAAAAATTAAGTGGGCTGA AGAACTGATTGCTGCCTTTAAAGAACATCAACAATTAGGAAAGGGGGCCTTTACTTTCCAAGGGAGTATGATCGACATGCCATTACTGAA GCAGGCCCAGAACACTGTTACGCTTGCCACCTCCATCAAGGAAAAATGATCTGTTAAATGAAGCTGTCATCAGGCTAAAGGGTATTGAAG CTGCAGAGGGATCAACTTGTGCTTGCCAGAGGACGCCAATGAAGTTTGAAACACCAACAATCAGAGATTTTGTTTCTGTTCCTCATTAAA >In-frame_ENST00000376387_ENST00000339105_TCGA-A7-A4SC-01A_TM9SF2_chr13_100201476_+_CLYBL_chr13_100425078_length(amino acids)=762AA_start in transcript=190_stop in transcript=2478 MSARLPVLSPPRWPRLLLLSLLLLGAVPGPRRSGAFYLPGLAPVNFCDEEKKSDECKAEIELFVNRLDSVESVLPYEYTAFDFCQASEGK RPSENLGQVLFGERIEPSPYKFTFNKKETCKLVCTKTYHTEKAEDKQKLEFLKKSMLLNYQHHWIVDNMPVTWCYDVEDGQRFCNPGFPI GCYITDKGHAKDACVISSDFHERDTFYIFNHVDIKIYYHVVETGSMGARLVAAKLEPKSFKHTHIDKPDCSGPPMDISNKASGEIKIAYT YSVSFEEDDKIRWASRWDYILESMPHTHIQWFSIMNSLVIVLFLSGMVAMIMLRTLHKDIARYNQMDSTEDAQEEFGWKLVHGDIFRPPR KGMLLSVFLGSGTQILIMTFVTLFFACLGFLSPANRGALMTCAVVLWVLLGTPAGYVAARFYKSFGGEKWKTNVLLTSFLCPGKASLAAD IPRLGYSSSSHHKYIPRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKNEARLRIVKTLEDIDLGPTEKCVRVNSVSSGLAEE DLETLLQSRVLPSSLMLPKVESPEEIQWFADKFSFHLKGRKLEQPMNLIPFVETAMGLLNFKAVCEETLKVGPQVGLFLDAVVFGGEDFR ASIGATSSKETLDILYARQKIVVIAKAFGLQAIDLVYIDFRDGAGLLRQSREGAAMGFTGKQVIHPNQIAVVQEQFSPSPEKIKWAEELI -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for TM9SF2-CLYBL |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for TM9SF2-CLYBL |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for TM9SF2-CLYBL |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |