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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMCC1-TNIK (FusionGDB2 ID:90741)

Fusion Gene Summary for TMCC1-TNIK

check button Fusion gene summary
Fusion gene informationFusion gene name: TMCC1-TNIK
Fusion gene ID: 90741
HgeneTgene
Gene symbol

TMCC1

TNIK

Gene ID

23023

23043

Gene nametransmembrane and coiled-coil domain family 1TRAF2 and NCK interacting kinase
Synonyms-MRT54
Cytomap

3q22.1

3q26.2-q26.31

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane and coiled-coil domains protein 1TRAF2 and NCK-interacting protein kinase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000432054, ENST00000393238, 
ENST00000426664, ENST00000329333, 
ENST00000515024, 		ENST00000436636, 
ENST00000538048, ENST00000369326, 
ENST00000341852, ENST00000284483, 
ENST00000470834, ENST00000460047, 
ENST00000475336, ENST00000488470, 
ENST00000357327, ENST00000464785, 
ENST00000465393, 
Fusion gene scores* DoF score15 X 14 X 5=105013 X 13 X 4=676
# samples 1716
** MAII scorelog2(17/1050*10)=-2.62678267641578
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/676*10)=-2.07895134139482
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMCC1 [Title/Abstract] AND TNIK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMCC1(129551619)-TNIK(170946012), # samples:1
TMCC1(129599152)-TNIK(170946010), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMCC1

GO:0016197

endosomal transport

30220460

HgeneTMCC1

GO:0090148

membrane fission

30220460

HgeneTMCC1

GO:0097750

endosome membrane tubulation

30220460

TgeneTNIK

GO:0006468

protein phosphorylation

10521462|15342639|22797597

TgeneTNIK

GO:0007256

activation of JNKK activity

15342639

TgeneTNIK

GO:0031532

actin cytoskeleton reorganization

15342639

TgeneTNIK

GO:0035556

intracellular signal transduction

10521462

TgeneTNIK

GO:0046777

protein autophosphorylation

10521462|15342639

TgeneTNIK

GO:0048814

regulation of dendrite morphogenesis

20159449


check buttonFusion gene breakpoints across TMCC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TNIK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4PE-01ATMCC1chr3

129551619

-TNIKchr3

170946012

-
ChimerDB4STADTCGA-BR-A4PE-01ATMCC1chr3

129599152

-TNIKchr3

170946010

-


Top

Fusion Gene ORF analysis for TMCC1-TNIK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000432054ENST00000436636TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000432054ENST00000538048TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000432054ENST00000369326TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000432054ENST00000341852TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000432054ENST00000284483TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000432054ENST00000470834TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000432054ENST00000460047TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000432054ENST00000475336TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000432054ENST00000488470TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000432054ENST00000357327TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-intronENST00000432054ENST00000464785TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-intronENST00000432054ENST00000465393TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-3CDSENST00000393238ENST00000436636TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-3CDSENST00000393238ENST00000538048TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-3CDSENST00000393238ENST00000369326TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-3CDSENST00000393238ENST00000341852TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-3CDSENST00000393238ENST00000284483TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-3CDSENST00000393238ENST00000470834TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-3CDSENST00000393238ENST00000460047TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-3CDSENST00000393238ENST00000475336TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-3CDSENST00000393238ENST00000488470TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-3CDSENST00000393238ENST00000357327TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-intronENST00000393238ENST00000464785TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-intronENST00000393238ENST00000465393TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-3CDSENST00000426664ENST00000436636TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-3CDSENST00000426664ENST00000538048TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-3CDSENST00000426664ENST00000369326TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-3CDSENST00000426664ENST00000341852TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-3CDSENST00000426664ENST00000284483TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-3CDSENST00000426664ENST00000470834TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-3CDSENST00000426664ENST00000460047TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-3CDSENST00000426664ENST00000475336TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-3CDSENST00000426664ENST00000488470TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-3CDSENST00000426664ENST00000357327TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-intronENST00000426664ENST00000464785TMCC1chr3

129551619

-TNIKchr3

170946012

-
5UTR-intronENST00000426664ENST00000465393TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000329333ENST00000436636TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000329333ENST00000538048TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000329333ENST00000369326TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000329333ENST00000341852TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000329333ENST00000284483TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000329333ENST00000470834TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000329333ENST00000460047TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000329333ENST00000475336TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000329333ENST00000488470TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000329333ENST00000357327TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-intronENST00000329333ENST00000464785TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-intronENST00000329333ENST00000465393TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000515024ENST00000436636TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000515024ENST00000538048TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000515024ENST00000369326TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000515024ENST00000341852TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000515024ENST00000284483TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000515024ENST00000470834TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000515024ENST00000460047TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000515024ENST00000475336TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000515024ENST00000488470TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000515024ENST00000357327TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-intronENST00000515024ENST00000464785TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-intronENST00000515024ENST00000465393TMCC1chr3

129551619

-TNIKchr3

170946012

-
intron-3CDSENST00000432054ENST00000436636TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000432054ENST00000538048TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000432054ENST00000369326TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000432054ENST00000341852TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000432054ENST00000284483TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000432054ENST00000470834TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000432054ENST00000460047TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000432054ENST00000475336TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000432054ENST00000488470TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000432054ENST00000357327TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-intronENST00000432054ENST00000464785TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-intronENST00000432054ENST00000465393TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-3CDSENST00000393238ENST00000436636TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-3CDSENST00000393238ENST00000538048TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-3CDSENST00000393238ENST00000369326TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-3CDSENST00000393238ENST00000341852TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-3CDSENST00000393238ENST00000284483TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-3CDSENST00000393238ENST00000470834TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-3CDSENST00000393238ENST00000460047TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-3CDSENST00000393238ENST00000475336TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-3CDSENST00000393238ENST00000488470TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-3CDSENST00000393238ENST00000357327TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-intronENST00000393238ENST00000464785TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-intronENST00000393238ENST00000465393TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000426664ENST00000436636TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000426664ENST00000538048TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000426664ENST00000369326TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000426664ENST00000341852TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000426664ENST00000284483TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000426664ENST00000470834TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000426664ENST00000460047TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000426664ENST00000475336TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000426664ENST00000488470TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000426664ENST00000357327TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-intronENST00000426664ENST00000464785TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-intronENST00000426664ENST00000465393TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000329333ENST00000436636TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000329333ENST00000538048TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000329333ENST00000369326TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000329333ENST00000341852TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000329333ENST00000284483TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000329333ENST00000470834TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000329333ENST00000460047TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000329333ENST00000475336TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000329333ENST00000488470TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-3CDSENST00000329333ENST00000357327TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-intronENST00000329333ENST00000464785TMCC1chr3

129599152

-TNIKchr3

170946010

-
intron-intronENST00000329333ENST00000465393TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-3CDSENST00000515024ENST00000436636TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-3CDSENST00000515024ENST00000538048TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-3CDSENST00000515024ENST00000369326TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-3CDSENST00000515024ENST00000341852TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-3CDSENST00000515024ENST00000284483TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-3CDSENST00000515024ENST00000470834TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-3CDSENST00000515024ENST00000460047TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-3CDSENST00000515024ENST00000475336TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-3CDSENST00000515024ENST00000488470TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-3CDSENST00000515024ENST00000357327TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-intronENST00000515024ENST00000464785TMCC1chr3

129599152

-TNIKchr3

170946010

-
5UTR-intronENST00000515024ENST00000465393TMCC1chr3

129599152

-TNIKchr3

170946010

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TMCC1-TNIK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMCC1-TNIK


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TMCC1-TNIK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for TMCC1-TNIK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMCC1-TNIK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMCC1-TNIK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTNIKC0036341Schizophrenia1PSYGENET
TgeneTNIKC0037274Dermatologic disorders1CTD_human
TgeneTNIKC0087031Juvenile-Onset Still Disease1CTD_human
TgeneTNIKC0274861Arsenic Poisoning, Inorganic1CTD_human
TgeneTNIKC0274862Nervous System, Organic Arsenic Poisoning1CTD_human
TgeneTNIKC0311375Arsenic Poisoning1CTD_human
TgeneTNIKC0751851Arsenic Encephalopathy1CTD_human
TgeneTNIKC0751852Arsenic Induced Polyneuropathy1CTD_human
TgeneTNIKC3495559Juvenile arthritis1CTD_human
TgeneTNIKC3714758Juvenile psoriatic arthritis1CTD_human
TgeneTNIKC4310755MENTAL RETARDATION, AUTOSOMAL RECESSIVE 541CTD_human;GENOMICS_ENGLAND
TgeneTNIKC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneTNIKC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human