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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMED10-IL6 (FusionGDB2 ID:90793)

Fusion Gene Summary for TMED10-IL6

check button Fusion gene summary
Fusion gene informationFusion gene name: TMED10-IL6
Fusion gene ID: 90793
HgeneTgene
Gene symbol

TMED10

IL6

Gene ID

10972

3569

Gene nametransmembrane p24 trafficking protein 10interleukin 6
SynonymsP24(DELTA)|S31I125|S31III125|TMP21|Tmp-21-I|p23|p24d1BSF-2|BSF2|CDF|HGF|HSF|IFN-beta-2|IFNB2|IL-6
Cytomap

14q24.3

7p15.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane emp24 domain-containing protein 1021 kDa transmembrane trafficking proteinp24 family protein delta-1p24deltap24delta1testicular tissue protein Li 206transmembrane emp24-like trafficking protein 10transmembrane protein Tmp21interleukin-6B-cell differentiation factorB-cell stimulatory factor 2CTL differentiation factorhybridoma growth factorinterferon beta-2interleukin BSF-2
Modification date2020031320200329
UniProtAcc.

P40189

Ensembl transtripts involved in fusion geneENST00000303575, ENST00000557670, 
ENST00000404625, ENST00000401651, 
ENST00000258743, ENST00000420258, 
ENST00000407492, ENST00000401630, 
ENST00000406575, 
Fusion gene scores* DoF score15 X 12 X 7=12601 X 1 X 1=1
# samples 191
** MAII scorelog2(19/1260*10)=-2.72935241005633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: TMED10 [Title/Abstract] AND IL6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIL6(22771050)-TMED10(75598821), # samples:1
TMED10(75598821)-IL6(22771050), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMED10

GO:0006886

intracellular protein transport

20427317

HgeneTMED10

GO:0035964

COPI-coated vesicle budding

10052452

TgeneIL6

GO:0001781

neutrophil apoptotic process

7595060

TgeneIL6

GO:0002384

hepatic immune response

2444978

TgeneIL6

GO:0002675

positive regulation of acute inflammatory response

2444978

TgeneIL6

GO:0006954

inflammatory response

10443688

TgeneIL6

GO:0008284

positive regulation of cell proliferation

2261637

TgeneIL6

GO:0010574

regulation of vascular endothelial growth factor production

8557680

TgeneIL6

GO:0010628

positive regulation of gene expression

19390056

TgeneIL6

GO:0010718

positive regulation of epithelial to mesenchymal transition

25916550

TgeneIL6

GO:0019221

cytokine-mediated signaling pathway

2261637|12643274

TgeneIL6

GO:0032722

positive regulation of chemokine production

10510402

TgeneIL6

GO:0032755

positive regulation of interleukin-6 production

10510402

TgeneIL6

GO:0032966

negative regulation of collagen biosynthetic process

12419823

TgeneIL6

GO:0033138

positive regulation of peptidyl-serine phosphorylation

7508917

TgeneIL6

GO:0042102

positive regulation of T cell proliferation

3130269

TgeneIL6

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

12643274|19390056

TgeneIL6

GO:0043065

positive regulation of apoptotic process

9949178

TgeneIL6

GO:0043066

negative regulation of apoptotic process

7595060

TgeneIL6

GO:0043410

positive regulation of MAPK cascade

7508917|12419823

TgeneIL6

GO:0045669

positive regulation of osteoblast differentiation

30545407

TgeneIL6

GO:0045727

positive regulation of translation

16732314

TgeneIL6

GO:0045893

positive regulation of transcription, DNA-templated

7749983|16606666

TgeneIL6

GO:0045944

positive regulation of transcription by RNA polymerase II

7508917|16946298|17324931

TgeneIL6

GO:0046427

positive regulation of JAK-STAT cascade

12419823|12552091|17324931

TgeneIL6

GO:0048661

positive regulation of smooth muscle cell proliferation

10510402

TgeneIL6

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

7508917

TgeneIL6

GO:0050871

positive regulation of B cell activation

3491322

TgeneIL6

GO:0051024

positive regulation of immunoglobulin secretion

3491322

TgeneIL6

GO:0051091

positive regulation of DNA-binding transcription factor activity

7749983

TgeneIL6

GO:0051092

positive regulation of NF-kappaB transcription factor activity

12419823

TgeneIL6

GO:0051384

response to glucocorticoid

10443688

TgeneIL6

GO:0051607

defense response to virus

3023045

TgeneIL6

GO:0060252

positive regulation of glial cell proliferation

2104886

TgeneIL6

GO:0070102

interleukin-6-mediated signaling pathway

12552091|16946298

TgeneIL6

GO:0070301

cellular response to hydrogen peroxide

19168699


check buttonFusion gene breakpoints across TMED10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across IL6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE619899TMED10chr14

75598821

+IL6chr7

22771050

-


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Fusion Gene ORF analysis for TMED10-IL6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000303575ENST00000404625TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000303575ENST00000401651TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000303575ENST00000258743TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000303575ENST00000420258TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000303575ENST00000407492TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000303575ENST00000401630TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000303575ENST00000406575TMED10chr14

75598821

+IL6chr7

22771050

-
intron-3CDSENST00000557670ENST00000404625TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000557670ENST00000401651TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000557670ENST00000258743TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000557670ENST00000420258TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000557670ENST00000407492TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000557670ENST00000401630TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000557670ENST00000406575TMED10chr14

75598821

+IL6chr7

22771050

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TMED10-IL6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMED10-IL6


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IL6

P40189

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Signal-transducing molecule (PubMed:2261637). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activate the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed:2261637, PubMed:19915009, PubMed:23294003). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003, PubMed:25731159). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity). {ECO:0000250|UniProtKB:Q00560, ECO:0000269|PubMed:19915009, ECO:0000269|PubMed:2261637, ECO:0000269|PubMed:23294003, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:28747427, ECO:0000269|PubMed:30309848}.; FUNCTION: [Isoform 2]: Binds to the soluble IL6:sIL6R complex (hyper-IL6), thereby blocking IL6 trans-signaling. Inhibits sIL6R-dependent acute phase response (PubMed:11121117, PubMed:21990364, PubMed:30279168). Also blocks IL11 cluster signaling through IL11R (PubMed:30279168). {ECO:0000269|PubMed:11121117, ECO:0000269|PubMed:21990364, ECO:0000269|PubMed:30279168}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TMED10-IL6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TMED10-IL6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMED10-IL6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMED10-IL6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIL6C0021368Inflammation11CTD_human
TgeneIL6C0011581Depressive disorder6CTD_human;PSYGENET
TgeneIL6C0041696Unipolar Depression6CTD_human;PSYGENET
TgeneIL6C0011206Delirium5PSYGENET
TgeneIL6C0011570Mental Depression5PSYGENET
TgeneIL6C0033578Prostatic Neoplasms5CTD_human
TgeneIL6C0035126Reperfusion Injury5CTD_human
TgeneIL6C0376358Malignant neoplasm of prostate5CTD_human
TgeneIL6C1269683Major Depressive Disorder5PSYGENET
TgeneIL6C0006142Malignant neoplasm of breast4CTD_human
TgeneIL6C0678222Breast Carcinoma4CTD_human
TgeneIL6C1257931Mammary Neoplasms, Human4CTD_human
TgeneIL6C1458155Mammary Neoplasms4CTD_human
TgeneIL6C2239176Liver carcinoma4CTD_human
TgeneIL6C4704874Mammary Carcinoma, Human4CTD_human
TgeneIL6C0003865Arthritis, Adjuvant-Induced3CTD_human
TgeneIL6C0015967Fever3CTD_human
TgeneIL6C0020429Hyperalgesia3CTD_human
TgeneIL6C0020538Hypertensive disease3CTD_human
TgeneIL6C0023290Leishmaniasis, Visceral3CTD_human
TgeneIL6C0026764Multiple Myeloma3CTD_human
TgeneIL6C0238281Middle Cerebral Artery Syndrome3CTD_human
TgeneIL6C0458247Allodynia3CTD_human
TgeneIL6C0740376Middle Cerebral Artery Thrombosis3CTD_human
TgeneIL6C0740391Middle Cerebral Artery Occlusion3CTD_human
TgeneIL6C0740392Infarction, Middle Cerebral Artery3CTD_human
TgeneIL6C0751211Hyperalgesia, Primary3CTD_human
TgeneIL6C0751212Hyperalgesia, Secondary3CTD_human
TgeneIL6C0751213Tactile Allodynia3CTD_human
TgeneIL6C0751214Hyperalgesia, Thermal3CTD_human
TgeneIL6C0751845Middle Cerebral Artery Embolus3CTD_human
TgeneIL6C0751846Left Middle Cerebral Artery Infarction3CTD_human
TgeneIL6C0751847Embolic Infarction, Middle Cerebral Artery3CTD_human
TgeneIL6C0751848Thrombotic Infarction, Middle Cerebral Artery3CTD_human
TgeneIL6C0751849Right Middle Cerebral Artery Infarction3CTD_human
TgeneIL6C0971858Arthritis, Collagen-Induced3CTD_human
TgeneIL6C0993582Arthritis, Experimental3CTD_human
TgeneIL6C2936719Mechanical Allodynia3CTD_human
TgeneIL6C0001973Alcoholic Intoxication, Chronic2PSYGENET
TgeneIL6C0003873Rheumatoid Arthritis2CTD_human
TgeneIL6C0005586Bipolar Disorder2PSYGENET
TgeneIL6C0007786Brain Ischemia2CTD_human
TgeneIL6C0009319Colitis2CTD_human
TgeneIL6C0010346Crohn Disease2CTD_human
TgeneIL6C0018801Heart failure2CTD_human
TgeneIL6C0018802Congestive heart failure2CTD_human
TgeneIL6C0019193Hepatitis, Toxic2CTD_human
TgeneIL6C0020649Hypotension2CTD_human
TgeneIL6C0022876Premature Obstetric Labor2CTD_human
TgeneIL6C0023212Left-Sided Heart Failure2CTD_human
TgeneIL6C0027051Myocardial Infarction2CTD_human
TgeneIL6C0028754Obesity2CTD_human
TgeneIL6C0034069Pulmonary Fibrosis2CTD_human
TgeneIL6C0156147Crohn's disease of large bowel2CTD_human
TgeneIL6C0235527Heart Failure, Right-Sided2CTD_human
TgeneIL6C0267380Crohn's disease of the ileum2CTD_human
TgeneIL6C0678202Regional enteritis2CTD_human
TgeneIL6C0860207Drug-Induced Liver Disease2CTD_human
TgeneIL6C0917798Cerebral Ischemia2CTD_human
TgeneIL6C0949272IIeocolitis2CTD_human
TgeneIL6C1262760Hepatitis, Drug-Induced2CTD_human
TgeneIL6C1959583Myocardial Failure2CTD_human
TgeneIL6C1961112Heart Decompensation2CTD_human
TgeneIL6C3658290Drug-Induced Acute Liver Injury2CTD_human
TgeneIL6C4277682Chemical and Drug Induced Liver Injury2CTD_human
TgeneIL6C4279912Chemically-Induced Liver Toxicity2CTD_human
TgeneIL6C4721507Alveolitis, Fibrosing2CTD_human
TgeneIL6C0000786Spontaneous abortion1CTD_human
TgeneIL6C0000822Abortion, Tubal1CTD_human
TgeneIL6C0001787Osteoporosis, Age-Related1CTD_human
TgeneIL6C0001925Albuminuria1CTD_human
TgeneIL6C0002152Alloxan Diabetes1CTD_human
TgeneIL6C0002622Amnesia1CTD_human
TgeneIL6C0004096Asthma1CTD_human
TgeneIL6C0004153Atherosclerosis1CTD_human
TgeneIL6C0004352Autistic Disorder1CTD_human
TgeneIL6C0004364Autoimmune Diseases1CTD_human
TgeneIL6C0005138Berylliosis1CTD_human
TgeneIL6C0005398Cholestasis, Extrahepatic1CTD_human
TgeneIL6C0006625Cachexia1CTD_human
TgeneIL6C0007134Renal Cell Carcinoma1CTD_human
TgeneIL6C0007137Squamous cell carcinoma1CTD_human
TgeneIL6C0007621Neoplastic Cell Transformation1CTD_human
TgeneIL6C0008370Cholestasis1CTD_human
TgeneIL6C0010246Coxsackievirus Infections1CTD_human
TgeneIL6C0011573Endogenous depression1CTD_human
TgeneIL6C0011615Dermatitis, Atopic1CTD_human
TgeneIL6C0011853Diabetes Mellitus, Experimental1CTD_human
TgeneIL6C0013604Edema1CTD_human
TgeneIL6C0014324Entamoebiasis1CTD_human
TgeneIL6C0017531Angiolymphoid hyperplasia1CTD_human
TgeneIL6C0017658Glomerulonephritis1CTD_human
TgeneIL6C0018681Headache1CTD_human
TgeneIL6C0019061Hemolytic-Uremic Syndrome1CTD_human
TgeneIL6C0019202Hepatolenticular Degeneration1CTD_human
TgeneIL6C0019207Hepatoma, Morris1CTD_human
TgeneIL6C0019208Hepatoma, Novikoff1CTD_human
TgeneIL6C0019284Diaphragmatic Hernia1CTD_human
TgeneIL6C0020437Hypercalcemia1CTD_human
TgeneIL6C0020456Hyperglycemia1CTD_human
TgeneIL6C0020500Hyperoxaluria1CTD_human
TgeneIL6C0020503Hyperparathyroidism, Secondary1CTD_human
TgeneIL6C0020517Hypersensitivity1CTD_human
TgeneIL6C0022116Ischemia1CTD_human
TgeneIL6C0022333Jacksonian Seizure1CTD_human
TgeneIL6C0022660Kidney Failure, Acute1CTD_human
TgeneIL6C0022661Kidney Failure, Chronic1CTD_human
TgeneIL6C0023281Leishmaniasis1CTD_human
TgeneIL6C0023434Chronic Lymphocytic Leukemia1CTD_human
TgeneIL6C0023890Liver Cirrhosis1CTD_human
TgeneIL6C0023891Liver Cirrhosis, Alcoholic1CTD_human
TgeneIL6C0023904Liver Neoplasms, Experimental1CTD_human
TgeneIL6C0024117Chronic Obstructive Airway Disease1CTD_human
TgeneIL6C0024121Lung Neoplasms1CTD_human
TgeneIL6C0024141Lupus Erythematosus, Systemic1CTD_human
TgeneIL6C0024623Malignant neoplasm of stomach1CTD_human
TgeneIL6C0025193Melancholia1CTD_human
TgeneIL6C0025290Aseptic Meningitis1CTD_human
TgeneIL6C0026141Milk-Alkali Syndrome1CTD_human
TgeneIL6C0027059Myocarditis1CTD_human
TgeneIL6C0027540Necrosis1CTD_human
TgeneIL6C0027626Neoplasm Invasiveness1CTD_human
TgeneIL6C0027627Neoplasm Metastasis1CTD_human
TgeneIL6C0028043Nicotine Dependence1CTD_human
TgeneIL6C0028838Ocular Headache1CTD_human
TgeneIL6C0029172Oral Submucous Fibrosis1CTD_human
TgeneIL6C0029456Osteoporosis1CTD_human
TgeneIL6C0029458Osteoporosis, Postmenopausal1CTD_human
TgeneIL6C0029459Osteoporosis, Senile1CTD_human
TgeneIL6C0030246Pustulosis of Palms and Soles1CTD_human
TgeneIL6C0030567Parkinson Disease1CTD_human
TgeneIL6C0032226Pleural Diseases1CTD_human
TgeneIL6C0032231Pleurisy1CTD_human
TgeneIL6C0032285Pneumonia1CTD_human
TgeneIL6C0032300Lobar Pneumonia1CTD_human
TgeneIL6C0032927Precancerous Conditions1CTD_human
TgeneIL6C0032963Pregnancy Complications, Cardiovascular1CTD_human
TgeneIL6C0033141Cardiomyopathies, Primary1CTD_human
TgeneIL6C0033860Psoriasis1CTD_human
TgeneIL6C0035228Respiratory Hypersensitivity1CTD_human
TgeneIL6C0036341Schizophrenia1CTD_human
TgeneIL6C0036529Myocardial Diseases, Secondary1CTD_human
TgeneIL6C0036572Seizures1CTD_human
TgeneIL6C0036982Shock, Hemorrhagic1CTD_human
TgeneIL6C0037274Dermatologic disorders1CTD_human
TgeneIL6C0038356Stomach Neoplasms1CTD_human
TgeneIL6C0038433Streptozotocin Diabetes1CTD_human
TgeneIL6C0038454Cerebrovascular accident1CTD_human
TgeneIL6C0040136Thyroid Neoplasm1CTD_human
TgeneIL6C0040332Tobacco Dependence1CTD_human
TgeneIL6C0085655Polymyositis1CTD_human
TgeneIL6C0086133Depressive Syndrome1CTD_human
TgeneIL6C0086196Eczema, Infantile1CTD_human
TgeneIL6C0086404Experimental Hepatoma1CTD_human
TgeneIL6C0149958Complex partial seizures1CTD_human
TgeneIL6C0151468Thyroid Gland Follicular Adenoma1CTD_human
TgeneIL6C0151526Premature Birth1CTD_human
TgeneIL6C0151603Anasarca1CTD_human
TgeneIL6C0151744Myocardial Ischemia1CTD_human
TgeneIL6C0162668Megaconial Myopathies1CTD_human
TgeneIL6C0162669Pleoconial Myopathies1CTD_human
TgeneIL6C0162670Mitochondrial Myopathies1CTD_human
TgeneIL6C0162848Lichenoid Eruptions1CTD_human
TgeneIL6C0206698Cholangiocarcinoma1CTD_human
TgeneIL6C0233750Hysterical amnesia1CTD_human
TgeneIL6C0233796Temporary Amnesia1CTD_human
TgeneIL6C0234533Generalized seizures1CTD_human
TgeneIL6C0234535Clonic Seizures1CTD_human
TgeneIL6C0236795Dissociative Amnesia1CTD_human
TgeneIL6C0239946Fibrosis, Liver1CTD_human
TgeneIL6C0239981Hypoalbuminemia1CTD_human
TgeneIL6C0241910Autoimmune Chronic Hepatitis1CTD_human
TgeneIL6C0242379Malignant neoplasm of lung1CTD_human
TgeneIL6C0242380Libman-Sacks Disease1CTD_human
TgeneIL6C0242698Ventricular Dysfunction, Left1CTD_human
TgeneIL6C0262497Global Amnesia1CTD_human
TgeneIL6C0263984Polymyositis Ossificans1CTD_human
TgeneIL6C0270715Degenerative Diseases, Central Nervous System1CTD_human
TgeneIL6C0270824Visual seizure1CTD_human
TgeneIL6C0270844Tonic Seizures1CTD_human
TgeneIL6C0270846Epileptic drop attack1CTD_human
TgeneIL6C0273115Lung Injury1CTD_human
TgeneIL6C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneIL6C0282126Depression, Neurotic1CTD_human
TgeneIL6C0282313Condition, Preneoplastic1CTD_human
TgeneIL6C0338715Drug-induced depressive state1PSYGENET
TgeneIL6C0343755HIV Wasting Syndrome1CTD_human
TgeneIL6C0345905Intrahepatic Cholangiocarcinoma1CTD_human
TgeneIL6C0345967Malignant mesothelioma1CTD_human
TgeneIL6C0376384Nicotine Use Disorder1CTD_human
TgeneIL6C0422850Seizures, Somatosensory1CTD_human
TgeneIL6C0422852Seizures, Auditory1CTD_human
TgeneIL6C0422853Olfactory seizure1CTD_human
TgeneIL6C0422854Gustatory seizure1CTD_human
TgeneIL6C0422855Vertiginous seizure1CTD_human
TgeneIL6C0423618Throbbing Headache1CTD_human
TgeneIL6C0423623Bilateral Headache1CTD_human
TgeneIL6C0474366Generalized Headache1CTD_human
TgeneIL6C0494475Tonic - clonic seizures1CTD_human
TgeneIL6C0524620Metabolic Syndrome X1CTD_human
TgeneIL6C0524851Neurodegenerative Disorders1CTD_human
TgeneIL6C0549473Thyroid carcinoma1CTD_human
TgeneIL6C0554591Polymyositis, Idiopathic1CTD_human
TgeneIL6C0750906Tactile Amnesia1CTD_human
TgeneIL6C0750907Amnestic State1CTD_human
TgeneIL6C0751056Non-epileptic convulsion1CTD_human
TgeneIL6C0751110Single Seizure1CTD_human
TgeneIL6C0751123Atonic Absence Seizures1CTD_human
TgeneIL6C0751186Orthostatic Headache1CTD_human
TgeneIL6C0751187Periorbital Headache1CTD_human
TgeneIL6C0751189Retro-Ocular Headache1CTD_human
TgeneIL6C0751190Sharp Headache1CTD_human
TgeneIL6C0751192Vertex Headache1CTD_human
TgeneIL6C0751406Post-Traumatic Osteoporosis1CTD_human
TgeneIL6C0751494Convulsive Seizures1CTD_human
TgeneIL6C0751495Seizures, Focal1CTD_human
TgeneIL6C0751496Seizures, Sensory1CTD_human
TgeneIL6C0751733Degenerative Diseases, Spinal Cord1CTD_human
TgeneIL6C0751956Acute Cerebrovascular Accidents1CTD_human
TgeneIL6C0869523Carditis1CTD_human
TgeneIL6C0877781Hemicrania1CTD_human
TgeneIL6C0878544Cardiomyopathies1CTD_human
TgeneIL6C0887898Experimental Lung Inflammation1CTD_human
TgeneIL6C0919267ovarian neoplasm1CTD_human
TgeneIL6C0948089Acute Coronary Syndrome1CTD_human
TgeneIL6C0949496Luft Disease1CTD_human
TgeneIL6C1140680Malignant neoplasm of ovary1CTD_human
TgeneIL6C1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneIL6C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneIL6C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneIL6C1298681Oxalosis1CTD_human
TgeneIL6C1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneIL6C1368275Pigmented Basal Cell Carcinoma1CTD_human
TgeneIL6C1527303Chronic Airflow Obstruction1CTD_human
TgeneIL6C1527304Allergic Reaction1CTD_human
TgeneIL6C1527352Hepatic Form of Wilson Disease1CTD_human
TgeneIL6C1563937Atherogenesis1CTD_human
TgeneIL6C1565662Acute Kidney Insufficiency1CTD_human
TgeneIL6C1704377Bright Disease1CTD_human
TgeneIL6C1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneIL6C1855520Hyperglycemia, Postprandial1CTD_human
TgeneIL6C2350344Chronic Lung Injury1CTD_human
TgeneIL6C2350873Beryllium Disease1CTD_human
TgeneIL6C2609414Acute kidney injury1CTD_human
TgeneIL6C3495874Nonepileptic Seizures1CTD_human
TgeneIL6C3714636Pneumonitis1CTD_human
TgeneIL6C3805278Extrahepatic Cholangiocarcinoma1CTD_human
TgeneIL6C3830362Early Pregnancy Loss1CTD_human
TgeneIL6C4048158Convulsions1CTD_human
TgeneIL6C4316791Entamoeba histolytica Infection1CTD_human
TgeneIL6C4316903Absence Seizures1CTD_human
TgeneIL6C4317109Epileptic Seizures1CTD_human
TgeneIL6C4317123Myoclonic Seizures1CTD_human
TgeneIL6C4505436Generalized Absence Seizures1CTD_human
TgeneIL6C4552766Miscarriage1CTD_human
TgeneIL6C4721453Peripheral Nervous System Diseases1CTD_human
TgeneIL6C4721806Carcinoma, Basal Cell1CTD_human