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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMED5-RAB18 (FusionGDB2 ID:90835)

Fusion Gene Summary for TMED5-RAB18

check button Fusion gene summary
Fusion gene informationFusion gene name: TMED5-RAB18
Fusion gene ID: 90835
HgeneTgene
Gene symbol

TMED5

RAB18

Gene ID

50999

22931

Gene nametransmembrane p24 trafficking protein 5RAB18, member RAS oncogene family
SynonymsCGI-100|p24g2|p28RAB18LI1|WARBM3
Cytomap

1p22.1

10p12.1

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane emp24 domain-containing protein 5p24 family protein gamma-2p24gamma2transmembrane emp24 protein transport domain containing 5ras-related protein Rab-18RAB18 small GTPase
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000370282, ENST00000483033, 
ENST00000479918, ENST00000370280, 
ENST00000356940, ENST00000535776, 
ENST00000375802, ENST00000465772, 
Fusion gene scores* DoF score8 X 5 X 6=2408 X 7 X 4=224
# samples 99
** MAII scorelog2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/224*10)=-1.31550182572793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMED5 [Title/Abstract] AND RAB18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMED5(93645610)-RAB18(27821435), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TMED5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RAB18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-IN-A6RNTMED5chr1

93645610

-RAB18chr10

27821435

+


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Fusion Gene ORF analysis for TMED5-RAB18

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000370282ENST00000356940TMED5chr1

93645610

-RAB18chr10

27821435

+
5CDS-intronENST00000370282ENST00000535776TMED5chr1

93645610

-RAB18chr10

27821435

+
5CDS-intronENST00000370282ENST00000375802TMED5chr1

93645610

-RAB18chr10

27821435

+
5CDS-3UTRENST00000370282ENST00000465772TMED5chr1

93645610

-RAB18chr10

27821435

+
intron-3CDSENST00000483033ENST00000356940TMED5chr1

93645610

-RAB18chr10

27821435

+
intron-intronENST00000483033ENST00000535776TMED5chr1

93645610

-RAB18chr10

27821435

+
intron-intronENST00000483033ENST00000375802TMED5chr1

93645610

-RAB18chr10

27821435

+
intron-3UTRENST00000483033ENST00000465772TMED5chr1

93645610

-RAB18chr10

27821435

+
In-frameENST00000479918ENST00000356940TMED5chr1

93645610

-RAB18chr10

27821435

+
5CDS-intronENST00000479918ENST00000535776TMED5chr1

93645610

-RAB18chr10

27821435

+
5CDS-intronENST00000479918ENST00000375802TMED5chr1

93645610

-RAB18chr10

27821435

+
5CDS-3UTRENST00000479918ENST00000465772TMED5chr1

93645610

-RAB18chr10

27821435

+
In-frameENST00000370280ENST00000356940TMED5chr1

93645610

-RAB18chr10

27821435

+
5CDS-intronENST00000370280ENST00000535776TMED5chr1

93645610

-RAB18chr10

27821435

+
5CDS-intronENST00000370280ENST00000375802TMED5chr1

93645610

-RAB18chr10

27821435

+
5CDS-3UTRENST00000370280ENST00000465772TMED5chr1

93645610

-RAB18chr10

27821435

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370282TMED5chr193645610-ENST00000356940RAB18chr1027821435+52736754861109207
ENST00000479918TMED5chr193645610-ENST00000356940RAB18chr1027821435+4906308119742207
ENST00000370280TMED5chr193645610-ENST00000356940RAB18chr1027821435+480620819642207

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370282ENST00000356940TMED5chr193645610-RAB18chr1027821435+0.0002918650.9997081
ENST00000479918ENST00000356940TMED5chr193645610-RAB18chr1027821435+0.0002741930.99972576
ENST00000370280ENST00000356940TMED5chr193645610-RAB18chr1027821435+0.0002642540.9997358

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Fusion Genomic Features for TMED5-RAB18


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TMED5chr193645610-RAB18chr1027821435+0.0001948490.99980515
TMED5chr193645610-RAB18chr1027821435+0.0001948490.99980515

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMED5-RAB18


check button Go to

FGviewer for the breakpoints of chr1:93645610-chr10:27821435

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRAB18chr1:93645610chr10:27821435ENST000005357760537_450143.0MotifEffector region
TgeneRAB18chr1:93645610chr10:27821435ENST0000035694027122_12562.0207.0Nucleotide bindingNote=GTP
TgeneRAB18chr1:93645610chr10:27821435ENST0000035694027151_15362.0207.0Nucleotide bindingNote=GTP
TgeneRAB18chr1:93645610chr10:27821435ENST000003569402763_6762.0207.0Nucleotide bindingNote=GTP
TgeneRAB18chr1:93645610chr10:27821435ENST0000053577605122_1250143.0Nucleotide bindingNote=GTP
TgeneRAB18chr1:93645610chr10:27821435ENST0000053577605151_1530143.0Nucleotide bindingNote=GTP
TgeneRAB18chr1:93645610chr10:27821435ENST000005357760515_230143.0Nucleotide bindingNote=GTP
TgeneRAB18chr1:93645610chr10:27821435ENST000005357760563_670143.0Nucleotide bindingNote=GTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMED5chr1:93645610chr10:27821435ENST00000370282-1445_12663.0230.0DomainGOLD
HgeneTMED5chr1:93645610chr10:27821435ENST00000479918-1545_12663.0194.0DomainGOLD
HgeneTMED5chr1:93645610chr10:27821435ENST00000370282-14218_22963.0230.0Topological domainCytoplasmic
HgeneTMED5chr1:93645610chr10:27821435ENST00000370282-1428_19663.0230.0Topological domainLumenal
HgeneTMED5chr1:93645610chr10:27821435ENST00000479918-15218_22963.0194.0Topological domainCytoplasmic
HgeneTMED5chr1:93645610chr10:27821435ENST00000479918-1528_19663.0194.0Topological domainLumenal
HgeneTMED5chr1:93645610chr10:27821435ENST00000370282-14197_21763.0230.0TransmembraneHelical
HgeneTMED5chr1:93645610chr10:27821435ENST00000479918-15197_21763.0194.0TransmembraneHelical
TgeneRAB18chr1:93645610chr10:27821435ENST000003569402737_4562.0207.0MotifEffector region
TgeneRAB18chr1:93645610chr10:27821435ENST000003569402715_2362.0207.0Nucleotide bindingNote=GTP


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Fusion Gene Sequence for TMED5-RAB18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000370282_ENST00000356940_TCGA-IN-A6RN_TMED5_chr1_93645610_-_RAB18_chr10_27821435_length(transcript)=5273nt_BP=675nt
GAACCGCCGCGGGAGCCGTTGGGACGCGCCTACCCGGTCACTGCCCCGCCCCGGCGCAGACTGCGTGAGGCGCCGCCGAAGGCGCGGGGC
TTGCCGGGGATCGTGGTCGGCGAGCGCGCCCGAGCCCACTAGCGGAGCCCGCCCGGGACTACATTTCCCACAATTACCGCCATGATGCCC
ATTGGTGGGGGAAGCCATGGGAACCGGAGGCCGTCAGGGGGAGAGGCGGGCGGCGCTCACGCCTGGCCTGAGGGGGCCGAGACTGAGGCG
GTTGCGGAATAGGACTGCTAGCCCCGCCCAGAGTCCCTACCCTTTGGAGAACTGCGCTTCTCTTTCGGAGGGAGTGTTCGCCGCCGCCGC
GGCCGCCACCTGGAGTTTCTTCAGACTCCAGATTTCCCTGTCAACCACGAGGAGTCCAGAGAGGAAACGCGGAGCGGAGACAACAGTACC
TGACGCCTCTTTCAGCCCGGGATCGCCCCAGCAGGGATGGGCGACAAGATCTGGCTGCCCTTCCCCGTGCTCCTTCTGGCCGCTCTGCCT
CCGGTGCTGCTGCCTGGGGCGGCCGGCTTCACACCTTCCCTCGATAGCGACTTCACCTTTACCCTTCCCGCCGGCCAGAAGGAGTGCTTC
TACCAGCCCATGCCCCTGAAGGCCTCGCTGGAGATCGAGTACCAAGATACTGCTGGTCAAGAGAGGTTTAGAACATTAACTCCCAGCTAT
TATAGAGGTGCACAGGGTGTTATATTAGTTTATGATGTCACAAGAAGAGATACATTTGTTAAACTGGATAATTGGTTAAATGAATTGGAA
ACATACTGTACAAGAAATGACATAGTAAACATGCTAGTTGGAAATAAAATCGATAAGGAAAATCGTGAAGTCGATAGAAATGAAGGCCTG
AAATTTGCACGAAAGCATTCCATGTTATTTATAGAGGCAAGTGCAAAAACCTGTGATGGTGTACAATGTGCCTTTGAAGAACTTGTTGAA
AAGATCATTCAGACCCCTGGACTGTGGGAAAGTGAGAACCAGAATAAAGGAGTCAAACTGTCACACAGGGAAGAAGGCCAAGGAGGAGGA
GCCTGTGGTGGTTATTGCTCTGTGTTATAAACTCTGGGAAATTCCATCTCTTGCATATTTGATCAGATAGTGACATCTTTCTGTATATAA
ACTCTTTAACTGCTATTTTAGGGACCTTGCAGTTTGCACATAATTGTTTTATATCATAGCAGTAAATATTTGCAAGAAATCCCACTCATC
GACCCCGGGTAAAATGTTATGGTAAGCATGCACAGTTTGCAGTCTACAGTTTTTTTATGTAGCACAAAATAGGTGTACCTTTATAAGTAC
ATTCAATTTTATGATTTACATTTATCATGTAATTTTTAAAAAAATCCATCTATCTAGGATATGTTGATACAAAGTCTGCTTTTGCTATTC
TTTTTGCTTAAATACTCCTATCATTTTCTGAATTACTTGGTATTTAGAACTCCTAGCACCACGGGGAAGAATAGAGGTATCATCAAACGT
GGCAAATTTTCTTTCAGGAATAATAAAGAGCATGATTCCACAGCTTTTCTGGGATGTTTGAGATTCTTTTTTAGTACTAAGCAAAATTCT
CATCACAGAATGTAGCCCAGGCCAATTTATAACTAAATCTCTATTTGTTCAGATGATGCTTCTAAAACAGCATTGATAGGTTAAAGAAGC
TTGGTATTTTTAATTTACTTCAATGATTAGCTCAGTTGCTTAACTGGAGTTTTAATCCTGTGATATGTACATTGGATTCATGACTGTGCA
GCATTTTTAGTTATGTGGTGTTTGGCAGAATGACAATAAGGTTTTCCCCCATTTTGGTTTCAGGAGGACATGAATAGTGTGTTTATTGTA
ACTCCTCATACACTTTTAAAACCAACATCTTTTTTCATAAATGTTGGTAGTGTTTGTCCAGGTACCTTAACTGTAGCTTGTGTAATGTTG
ATGAATATCTGTATCTTACGGCTTCCATAATGGCTAGTTGATATTCAAAAACCTATTTCTGTGTTTTGAGGGGTGGGGAAAAAAAACACT
AAGTGATAATTTGAAAAAGGCATATTGCTTCCAGATTCTGATGTGTGAGGGAAAATACTGTCACAATGAAAATCTTGACAATTTACTTAA
CAAGTAACCAGTAGTTCATCAAAACCAACTTGTACAGACTAATAAATCTTTTTCACAGTATTCAGTTTTCTCACCTCTTGCTATTGTATA
TTGTAGATTTTTTTCATTCATGTGTTATTTAATTTACACTGATCTCTGCTATTTTAACCCCCCAAATAAGTTATTTGTCCTTTAAGGTTG
GTTACTATAATACCCCTCAGTAAGATTCCAGTATTAATTTCTGGGCAGTTTGTTCTCTGTATACAATTGCAAATGATAAGCATTTTTGTG
AGTGACCACCTTTGCAATATGTTTGTTAATTTACTTCATGTTGGGTTCTTTCTGAAATGTACATCTTTACATATAAAAACCTCACATTCT
ACTTGATTTACACTTCCTAGTCTACATTACATGTGGTTGAAGGTTTTATACATTCTATATGCTTTTACTAAATATACAAGATTTACTACT
AGAAATTTGGAGAAAGAACACTAACACATGTACTTGTGATTTGTTCATGTTATATTAAAACTTGAGATTTGTGTATTTATGTAGAGTCTG
TATTGACAAGACTGTTGTTTTTTGCTCCTTGAGCTATATAATAATCTGTGTATTGGATTGTTGTCTTGATTTGGTCTAAATTTGAATATA
TATGAGTTACTTGAATATAACAAAAATGAATTTTGTTTGATAGATTTATATTGTAACCTTTTTCTAGTTCTTGAATAAATATAGCCTGCT
TTCCCTAGATGCATTTGTGTAGGAAGTATATACATTTCCCTATTACTCTCATCAGCTGAAGAATATGTACTATTGTGTTACTCAAATTAT
GTGGCTTTCATTTTGTTGTTTTGTTGCAAGCTTAGTGTTTTGTAGTGGAGGTTTTGTAAATGAAACAGTTGTAATATCTAAGGTCAGGCA
CCTAGTAACAGGGTTTTGTTAATTCTTTTCAGAATCATTGAAGCAGTCTTAAAGGGTCTTTTGCAGATGGTACAAATTAGAACAATTAGA
ATATAGTATTTTGAGTTCTAGTAGTACTGAGATTGACCCAAACAAATAAAAAACTATTCAATTTCTGAGTAATAGTTAATATTTATTGAA
AGCTTCCTTGGTGCCAGATGCCTTTCTAAGTGCTGAATTATCTCATTAAACCTCACAGCAACCTTAAGAGATTAGTACTCCTATTATGCC
CATTTTAAAGGTGAGGACAACACAATGTAGGTATGTTAGGTAACCCCCAAAGATCACATAGCTACTCAGTCACTGAGCTGGATTCCAGTC
ATGGCATTTTTACTTCTGAGCCCATACTCTTCACCATCGCTCATTTTACAATGGGTAGTTAGTTACCAGCTTTTTGTAACACAACCAAGT
TAAGGCAGTTCCACTATTTCTTTATCACTCTTTTGTTATATGTAATAGAAGTATTTCACACTTTTGGGTTATAGAGTAAATCCCATGATG
TAAACCTACCTCATAAGTCATGTGACATAAAAGTTAAGGTAGTGGAGTAGGTGGTCTTATTTCTTTCACCTGCTCAGAGTGGACTGAAAA
TCCTGACTTAGAAAAGGTACAAAGTTAGGGGACTTATGGTACCTTCACTTTTTATGTGAGAATAGAAATTATGGAAACAGTAATTTGCTC
AAAACTGAAATCTGGGGTGATGTTTTCATTTCATGTATTTGATTGCCATCCATAAACTCATACTTGGTGTTGACATTCTAGCTGAGTGTT
GTGGAAATAGACTTGATTTTGATTCATCGTAGCTTGCATGGTCAAGAGACATGATTCTCTACTAAGGGTGGGGCTAGCACCATAGCTCAT
AAAAGAATCCTTCTTACACCAGTACTTGTTCTGCCTGTGAGTTGGCACAGACTTACCTAATAACCATAGTGTCTTTAAGTACAACTTAAT
ACATATTTTTTCTGTGTATTTTTTTCAAATGAACTCAACAATTCTTCAGGTATTATAGATCAGAGATCCTCTCCATATTCAAGCATTATG
CTTCTCTTTCTTGGGGGTACATTTCACTAGTAATACTTAGGAAGTTATTTTGTCTTTCCTGTATTTCCCTAGTTAAGTATAGGGGTAAAA
ACGTTATTCAGCTTTCAGAAGACATTGTTCTGACTCCGACCCTGCCGTGTATACTCAACTATATAGACTTCACCCTGGGTTTTGCCTAAA
CTGTTGAAAGACGAGAATAAATAGACATAGACAGGCTAGCTAAGTCAAGACTAGGGGCTAAGGAATATAGAATCACCCAGGTCTTTTTTT
TTTTTTTTAATTTTTCTCTCCTCAGTTGGGAACATCTATCATGCTGGAGGACTACTGTGATGGGGCTTTACATTTTACTGTTTTGTTGCT
AGCTTATTGTTTCATACTTGGGAATCAGTCATGTTTCTGATTGTGGTATAAAGTTTGCTTAAGTGCCCCTTAGTTAAAGCTGTTCAATGA
ATGTAAGCACACACACACCTACACACATATTTTGAATAGTCGTGTGTTCATGCCTGTTCTCAGTCTTGTCCCCTTTACCGTTTCTCATGC
AGGTTATTTCTTGCTTTTTTTTTTTTTCCTCTTTTTTAACCGGAGAAGCAACAAATTACGTAGTTTTTTTTGTGTTTCTTTGATTACTAG
TGAGCTTGAGTACTTTTAATATTTTATTGGATATGTTTGTGACTGACTTTAATTTCTTGTTTGTGTGTGCTGTGGCTGCCCGATCCAGCA
CCTACTTCCTTCTCCCACCATACCACCCCCACCCCCACCCCTGCAAACAATTGGCATGTGGTTTGGGTGGCATTGTCACACCCTCGGCTT
TCTAGATTAACCCAGTTACCTTTTAGCAGTGCCCCACTTCCCCAGTAGCAATGGTTCAGGGGTAGGCACCTGACCCAGACCAGACTACTG
AGATAAAGATGTTTGCCTAGGCTTTTTCAGGAGCAATTGAAGACATCTTGTTGGAGATAGTGTGCTGGGAGGAGTCACATTCTGAACTTG
CTGCAGCTCGTTTTTCTAATATAAAGGAACCAGCCTGAGGCAGTACCAGGGTGAGAGGGAGTCTATTGGAGCCCTTGGGAACTTCTGGAT

>In-frame_ENST00000370282_ENST00000356940_TCGA-IN-A6RN_TMED5_chr1_93645610_-_RAB18_chr10_27821435_length(amino acids)=207AA_start in transcript=486_stop in transcript=1109
MGDKIWLPFPVLLLAALPPVLLPGAAGFTPSLDSDFTFTLPAGQKECFYQPMPLKASLEIEYQDTAGQERFRTLTPSYYRGAQGVILVYD
VTRRDTFVKLDNWLNELETYCTRNDIVNMLVGNKIDKENREVDRNEGLKFARKHSMLFIEASAKTCDGVQCAFEELVEKIIQTPGLWESE

--------------------------------------------------------------
>In-frame_ENST00000479918_ENST00000356940_TCGA-IN-A6RN_TMED5_chr1_93645610_-_RAB18_chr10_27821435_length(transcript)=4906nt_BP=308nt
ACCTGGAGTTTCTTCAGACTCCAGATTTCCCTGTCAACCACGAGGAGTCCAGAGAGGAAACGCGGAGCGGAGACAACAGTACCTGACGCC
TCTTTCAGCCCGGGATCGCCCCAGCAGGGATGGGCGACAAGATCTGGCTGCCCTTCCCCGTGCTCCTTCTGGCCGCTCTGCCTCCGGTGC
TGCTGCCTGGGGCGGCCGGCTTCACACCTTCCCTCGATAGCGACTTCACCTTTACCCTTCCCGCCGGCCAGAAGGAGTGCTTCTACCAGC
CCATGCCCCTGAAGGCCTCGCTGGAGATCGAGTACCAAGATACTGCTGGTCAAGAGAGGTTTAGAACATTAACTCCCAGCTATTATAGAG
GTGCACAGGGTGTTATATTAGTTTATGATGTCACAAGAAGAGATACATTTGTTAAACTGGATAATTGGTTAAATGAATTGGAAACATACT
GTACAAGAAATGACATAGTAAACATGCTAGTTGGAAATAAAATCGATAAGGAAAATCGTGAAGTCGATAGAAATGAAGGCCTGAAATTTG
CACGAAAGCATTCCATGTTATTTATAGAGGCAAGTGCAAAAACCTGTGATGGTGTACAATGTGCCTTTGAAGAACTTGTTGAAAAGATCA
TTCAGACCCCTGGACTGTGGGAAAGTGAGAACCAGAATAAAGGAGTCAAACTGTCACACAGGGAAGAAGGCCAAGGAGGAGGAGCCTGTG
GTGGTTATTGCTCTGTGTTATAAACTCTGGGAAATTCCATCTCTTGCATATTTGATCAGATAGTGACATCTTTCTGTATATAAACTCTTT
AACTGCTATTTTAGGGACCTTGCAGTTTGCACATAATTGTTTTATATCATAGCAGTAAATATTTGCAAGAAATCCCACTCATCGACCCCG
GGTAAAATGTTATGGTAAGCATGCACAGTTTGCAGTCTACAGTTTTTTTATGTAGCACAAAATAGGTGTACCTTTATAAGTACATTCAAT
TTTATGATTTACATTTATCATGTAATTTTTAAAAAAATCCATCTATCTAGGATATGTTGATACAAAGTCTGCTTTTGCTATTCTTTTTGC
TTAAATACTCCTATCATTTTCTGAATTACTTGGTATTTAGAACTCCTAGCACCACGGGGAAGAATAGAGGTATCATCAAACGTGGCAAAT
TTTCTTTCAGGAATAATAAAGAGCATGATTCCACAGCTTTTCTGGGATGTTTGAGATTCTTTTTTAGTACTAAGCAAAATTCTCATCACA
GAATGTAGCCCAGGCCAATTTATAACTAAATCTCTATTTGTTCAGATGATGCTTCTAAAACAGCATTGATAGGTTAAAGAAGCTTGGTAT
TTTTAATTTACTTCAATGATTAGCTCAGTTGCTTAACTGGAGTTTTAATCCTGTGATATGTACATTGGATTCATGACTGTGCAGCATTTT
TAGTTATGTGGTGTTTGGCAGAATGACAATAAGGTTTTCCCCCATTTTGGTTTCAGGAGGACATGAATAGTGTGTTTATTGTAACTCCTC
ATACACTTTTAAAACCAACATCTTTTTTCATAAATGTTGGTAGTGTTTGTCCAGGTACCTTAACTGTAGCTTGTGTAATGTTGATGAATA
TCTGTATCTTACGGCTTCCATAATGGCTAGTTGATATTCAAAAACCTATTTCTGTGTTTTGAGGGGTGGGGAAAAAAAACACTAAGTGAT
AATTTGAAAAAGGCATATTGCTTCCAGATTCTGATGTGTGAGGGAAAATACTGTCACAATGAAAATCTTGACAATTTACTTAACAAGTAA
CCAGTAGTTCATCAAAACCAACTTGTACAGACTAATAAATCTTTTTCACAGTATTCAGTTTTCTCACCTCTTGCTATTGTATATTGTAGA
TTTTTTTCATTCATGTGTTATTTAATTTACACTGATCTCTGCTATTTTAACCCCCCAAATAAGTTATTTGTCCTTTAAGGTTGGTTACTA
TAATACCCCTCAGTAAGATTCCAGTATTAATTTCTGGGCAGTTTGTTCTCTGTATACAATTGCAAATGATAAGCATTTTTGTGAGTGACC
ACCTTTGCAATATGTTTGTTAATTTACTTCATGTTGGGTTCTTTCTGAAATGTACATCTTTACATATAAAAACCTCACATTCTACTTGAT
TTACACTTCCTAGTCTACATTACATGTGGTTGAAGGTTTTATACATTCTATATGCTTTTACTAAATATACAAGATTTACTACTAGAAATT
TGGAGAAAGAACACTAACACATGTACTTGTGATTTGTTCATGTTATATTAAAACTTGAGATTTGTGTATTTATGTAGAGTCTGTATTGAC
AAGACTGTTGTTTTTTGCTCCTTGAGCTATATAATAATCTGTGTATTGGATTGTTGTCTTGATTTGGTCTAAATTTGAATATATATGAGT
TACTTGAATATAACAAAAATGAATTTTGTTTGATAGATTTATATTGTAACCTTTTTCTAGTTCTTGAATAAATATAGCCTGCTTTCCCTA
GATGCATTTGTGTAGGAAGTATATACATTTCCCTATTACTCTCATCAGCTGAAGAATATGTACTATTGTGTTACTCAAATTATGTGGCTT
TCATTTTGTTGTTTTGTTGCAAGCTTAGTGTTTTGTAGTGGAGGTTTTGTAAATGAAACAGTTGTAATATCTAAGGTCAGGCACCTAGTA
ACAGGGTTTTGTTAATTCTTTTCAGAATCATTGAAGCAGTCTTAAAGGGTCTTTTGCAGATGGTACAAATTAGAACAATTAGAATATAGT
ATTTTGAGTTCTAGTAGTACTGAGATTGACCCAAACAAATAAAAAACTATTCAATTTCTGAGTAATAGTTAATATTTATTGAAAGCTTCC
TTGGTGCCAGATGCCTTTCTAAGTGCTGAATTATCTCATTAAACCTCACAGCAACCTTAAGAGATTAGTACTCCTATTATGCCCATTTTA
AAGGTGAGGACAACACAATGTAGGTATGTTAGGTAACCCCCAAAGATCACATAGCTACTCAGTCACTGAGCTGGATTCCAGTCATGGCAT
TTTTACTTCTGAGCCCATACTCTTCACCATCGCTCATTTTACAATGGGTAGTTAGTTACCAGCTTTTTGTAACACAACCAAGTTAAGGCA
GTTCCACTATTTCTTTATCACTCTTTTGTTATATGTAATAGAAGTATTTCACACTTTTGGGTTATAGAGTAAATCCCATGATGTAAACCT
ACCTCATAAGTCATGTGACATAAAAGTTAAGGTAGTGGAGTAGGTGGTCTTATTTCTTTCACCTGCTCAGAGTGGACTGAAAATCCTGAC
TTAGAAAAGGTACAAAGTTAGGGGACTTATGGTACCTTCACTTTTTATGTGAGAATAGAAATTATGGAAACAGTAATTTGCTCAAAACTG
AAATCTGGGGTGATGTTTTCATTTCATGTATTTGATTGCCATCCATAAACTCATACTTGGTGTTGACATTCTAGCTGAGTGTTGTGGAAA
TAGACTTGATTTTGATTCATCGTAGCTTGCATGGTCAAGAGACATGATTCTCTACTAAGGGTGGGGCTAGCACCATAGCTCATAAAAGAA
TCCTTCTTACACCAGTACTTGTTCTGCCTGTGAGTTGGCACAGACTTACCTAATAACCATAGTGTCTTTAAGTACAACTTAATACATATT
TTTTCTGTGTATTTTTTTCAAATGAACTCAACAATTCTTCAGGTATTATAGATCAGAGATCCTCTCCATATTCAAGCATTATGCTTCTCT
TTCTTGGGGGTACATTTCACTAGTAATACTTAGGAAGTTATTTTGTCTTTCCTGTATTTCCCTAGTTAAGTATAGGGGTAAAAACGTTAT
TCAGCTTTCAGAAGACATTGTTCTGACTCCGACCCTGCCGTGTATACTCAACTATATAGACTTCACCCTGGGTTTTGCCTAAACTGTTGA
AAGACGAGAATAAATAGACATAGACAGGCTAGCTAAGTCAAGACTAGGGGCTAAGGAATATAGAATCACCCAGGTCTTTTTTTTTTTTTT
TAATTTTTCTCTCCTCAGTTGGGAACATCTATCATGCTGGAGGACTACTGTGATGGGGCTTTACATTTTACTGTTTTGTTGCTAGCTTAT
TGTTTCATACTTGGGAATCAGTCATGTTTCTGATTGTGGTATAAAGTTTGCTTAAGTGCCCCTTAGTTAAAGCTGTTCAATGAATGTAAG
CACACACACACCTACACACATATTTTGAATAGTCGTGTGTTCATGCCTGTTCTCAGTCTTGTCCCCTTTACCGTTTCTCATGCAGGTTAT
TTCTTGCTTTTTTTTTTTTTCCTCTTTTTTAACCGGAGAAGCAACAAATTACGTAGTTTTTTTTGTGTTTCTTTGATTACTAGTGAGCTT
GAGTACTTTTAATATTTTATTGGATATGTTTGTGACTGACTTTAATTTCTTGTTTGTGTGTGCTGTGGCTGCCCGATCCAGCACCTACTT
CCTTCTCCCACCATACCACCCCCACCCCCACCCCTGCAAACAATTGGCATGTGGTTTGGGTGGCATTGTCACACCCTCGGCTTTCTAGAT
TAACCCAGTTACCTTTTAGCAGTGCCCCACTTCCCCAGTAGCAATGGTTCAGGGGTAGGCACCTGACCCAGACCAGACTACTGAGATAAA
GATGTTTGCCTAGGCTTTTTCAGGAGCAATTGAAGACATCTTGTTGGAGATAGTGTGCTGGGAGGAGTCACATTCTGAACTTGCTGCAGC
TCGTTTTTCTAATATAAAGGAACCAGCCTGAGGCAGTACCAGGGTGAGAGGGAGTCTATTGGAGCCCTTGGGAACTTCTGGATCAAATTG

>In-frame_ENST00000479918_ENST00000356940_TCGA-IN-A6RN_TMED5_chr1_93645610_-_RAB18_chr10_27821435_length(amino acids)=207AA_start in transcript=119_stop in transcript=742
MGDKIWLPFPVLLLAALPPVLLPGAAGFTPSLDSDFTFTLPAGQKECFYQPMPLKASLEIEYQDTAGQERFRTLTPSYYRGAQGVILVYD
VTRRDTFVKLDNWLNELETYCTRNDIVNMLVGNKIDKENREVDRNEGLKFARKHSMLFIEASAKTCDGVQCAFEELVEKIIQTPGLWESE

--------------------------------------------------------------
>In-frame_ENST00000370280_ENST00000356940_TCGA-IN-A6RN_TMED5_chr1_93645610_-_RAB18_chr10_27821435_length(transcript)=4806nt_BP=208nt
CGGGATCGCCCCAGCAGGGATGGGCGACAAGATCTGGCTGCCCTTCCCCGTGCTCCTTCTGGCCGCTCTGCCTCCGGTGCTGCTGCCTGG
GGCGGCCGGCTTCACACCTTCCCTCGATAGCGACTTCACCTTTACCCTTCCCGCCGGCCAGAAGGAGTGCTTCTACCAGCCCATGCCCCT
GAAGGCCTCGCTGGAGATCGAGTACCAAGATACTGCTGGTCAAGAGAGGTTTAGAACATTAACTCCCAGCTATTATAGAGGTGCACAGGG
TGTTATATTAGTTTATGATGTCACAAGAAGAGATACATTTGTTAAACTGGATAATTGGTTAAATGAATTGGAAACATACTGTACAAGAAA
TGACATAGTAAACATGCTAGTTGGAAATAAAATCGATAAGGAAAATCGTGAAGTCGATAGAAATGAAGGCCTGAAATTTGCACGAAAGCA
TTCCATGTTATTTATAGAGGCAAGTGCAAAAACCTGTGATGGTGTACAATGTGCCTTTGAAGAACTTGTTGAAAAGATCATTCAGACCCC
TGGACTGTGGGAAAGTGAGAACCAGAATAAAGGAGTCAAACTGTCACACAGGGAAGAAGGCCAAGGAGGAGGAGCCTGTGGTGGTTATTG
CTCTGTGTTATAAACTCTGGGAAATTCCATCTCTTGCATATTTGATCAGATAGTGACATCTTTCTGTATATAAACTCTTTAACTGCTATT
TTAGGGACCTTGCAGTTTGCACATAATTGTTTTATATCATAGCAGTAAATATTTGCAAGAAATCCCACTCATCGACCCCGGGTAAAATGT
TATGGTAAGCATGCACAGTTTGCAGTCTACAGTTTTTTTATGTAGCACAAAATAGGTGTACCTTTATAAGTACATTCAATTTTATGATTT
ACATTTATCATGTAATTTTTAAAAAAATCCATCTATCTAGGATATGTTGATACAAAGTCTGCTTTTGCTATTCTTTTTGCTTAAATACTC
CTATCATTTTCTGAATTACTTGGTATTTAGAACTCCTAGCACCACGGGGAAGAATAGAGGTATCATCAAACGTGGCAAATTTTCTTTCAG
GAATAATAAAGAGCATGATTCCACAGCTTTTCTGGGATGTTTGAGATTCTTTTTTAGTACTAAGCAAAATTCTCATCACAGAATGTAGCC
CAGGCCAATTTATAACTAAATCTCTATTTGTTCAGATGATGCTTCTAAAACAGCATTGATAGGTTAAAGAAGCTTGGTATTTTTAATTTA
CTTCAATGATTAGCTCAGTTGCTTAACTGGAGTTTTAATCCTGTGATATGTACATTGGATTCATGACTGTGCAGCATTTTTAGTTATGTG
GTGTTTGGCAGAATGACAATAAGGTTTTCCCCCATTTTGGTTTCAGGAGGACATGAATAGTGTGTTTATTGTAACTCCTCATACACTTTT
AAAACCAACATCTTTTTTCATAAATGTTGGTAGTGTTTGTCCAGGTACCTTAACTGTAGCTTGTGTAATGTTGATGAATATCTGTATCTT
ACGGCTTCCATAATGGCTAGTTGATATTCAAAAACCTATTTCTGTGTTTTGAGGGGTGGGGAAAAAAAACACTAAGTGATAATTTGAAAA
AGGCATATTGCTTCCAGATTCTGATGTGTGAGGGAAAATACTGTCACAATGAAAATCTTGACAATTTACTTAACAAGTAACCAGTAGTTC
ATCAAAACCAACTTGTACAGACTAATAAATCTTTTTCACAGTATTCAGTTTTCTCACCTCTTGCTATTGTATATTGTAGATTTTTTTCAT
TCATGTGTTATTTAATTTACACTGATCTCTGCTATTTTAACCCCCCAAATAAGTTATTTGTCCTTTAAGGTTGGTTACTATAATACCCCT
CAGTAAGATTCCAGTATTAATTTCTGGGCAGTTTGTTCTCTGTATACAATTGCAAATGATAAGCATTTTTGTGAGTGACCACCTTTGCAA
TATGTTTGTTAATTTACTTCATGTTGGGTTCTTTCTGAAATGTACATCTTTACATATAAAAACCTCACATTCTACTTGATTTACACTTCC
TAGTCTACATTACATGTGGTTGAAGGTTTTATACATTCTATATGCTTTTACTAAATATACAAGATTTACTACTAGAAATTTGGAGAAAGA
ACACTAACACATGTACTTGTGATTTGTTCATGTTATATTAAAACTTGAGATTTGTGTATTTATGTAGAGTCTGTATTGACAAGACTGTTG
TTTTTTGCTCCTTGAGCTATATAATAATCTGTGTATTGGATTGTTGTCTTGATTTGGTCTAAATTTGAATATATATGAGTTACTTGAATA
TAACAAAAATGAATTTTGTTTGATAGATTTATATTGTAACCTTTTTCTAGTTCTTGAATAAATATAGCCTGCTTTCCCTAGATGCATTTG
TGTAGGAAGTATATACATTTCCCTATTACTCTCATCAGCTGAAGAATATGTACTATTGTGTTACTCAAATTATGTGGCTTTCATTTTGTT
GTTTTGTTGCAAGCTTAGTGTTTTGTAGTGGAGGTTTTGTAAATGAAACAGTTGTAATATCTAAGGTCAGGCACCTAGTAACAGGGTTTT
GTTAATTCTTTTCAGAATCATTGAAGCAGTCTTAAAGGGTCTTTTGCAGATGGTACAAATTAGAACAATTAGAATATAGTATTTTGAGTT
CTAGTAGTACTGAGATTGACCCAAACAAATAAAAAACTATTCAATTTCTGAGTAATAGTTAATATTTATTGAAAGCTTCCTTGGTGCCAG
ATGCCTTTCTAAGTGCTGAATTATCTCATTAAACCTCACAGCAACCTTAAGAGATTAGTACTCCTATTATGCCCATTTTAAAGGTGAGGA
CAACACAATGTAGGTATGTTAGGTAACCCCCAAAGATCACATAGCTACTCAGTCACTGAGCTGGATTCCAGTCATGGCATTTTTACTTCT
GAGCCCATACTCTTCACCATCGCTCATTTTACAATGGGTAGTTAGTTACCAGCTTTTTGTAACACAACCAAGTTAAGGCAGTTCCACTAT
TTCTTTATCACTCTTTTGTTATATGTAATAGAAGTATTTCACACTTTTGGGTTATAGAGTAAATCCCATGATGTAAACCTACCTCATAAG
TCATGTGACATAAAAGTTAAGGTAGTGGAGTAGGTGGTCTTATTTCTTTCACCTGCTCAGAGTGGACTGAAAATCCTGACTTAGAAAAGG
TACAAAGTTAGGGGACTTATGGTACCTTCACTTTTTATGTGAGAATAGAAATTATGGAAACAGTAATTTGCTCAAAACTGAAATCTGGGG
TGATGTTTTCATTTCATGTATTTGATTGCCATCCATAAACTCATACTTGGTGTTGACATTCTAGCTGAGTGTTGTGGAAATAGACTTGAT
TTTGATTCATCGTAGCTTGCATGGTCAAGAGACATGATTCTCTACTAAGGGTGGGGCTAGCACCATAGCTCATAAAAGAATCCTTCTTAC
ACCAGTACTTGTTCTGCCTGTGAGTTGGCACAGACTTACCTAATAACCATAGTGTCTTTAAGTACAACTTAATACATATTTTTTCTGTGT
ATTTTTTTCAAATGAACTCAACAATTCTTCAGGTATTATAGATCAGAGATCCTCTCCATATTCAAGCATTATGCTTCTCTTTCTTGGGGG
TACATTTCACTAGTAATACTTAGGAAGTTATTTTGTCTTTCCTGTATTTCCCTAGTTAAGTATAGGGGTAAAAACGTTATTCAGCTTTCA
GAAGACATTGTTCTGACTCCGACCCTGCCGTGTATACTCAACTATATAGACTTCACCCTGGGTTTTGCCTAAACTGTTGAAAGACGAGAA
TAAATAGACATAGACAGGCTAGCTAAGTCAAGACTAGGGGCTAAGGAATATAGAATCACCCAGGTCTTTTTTTTTTTTTTTAATTTTTCT
CTCCTCAGTTGGGAACATCTATCATGCTGGAGGACTACTGTGATGGGGCTTTACATTTTACTGTTTTGTTGCTAGCTTATTGTTTCATAC
TTGGGAATCAGTCATGTTTCTGATTGTGGTATAAAGTTTGCTTAAGTGCCCCTTAGTTAAAGCTGTTCAATGAATGTAAGCACACACACA
CCTACACACATATTTTGAATAGTCGTGTGTTCATGCCTGTTCTCAGTCTTGTCCCCTTTACCGTTTCTCATGCAGGTTATTTCTTGCTTT
TTTTTTTTTTCCTCTTTTTTAACCGGAGAAGCAACAAATTACGTAGTTTTTTTTGTGTTTCTTTGATTACTAGTGAGCTTGAGTACTTTT
AATATTTTATTGGATATGTTTGTGACTGACTTTAATTTCTTGTTTGTGTGTGCTGTGGCTGCCCGATCCAGCACCTACTTCCTTCTCCCA
CCATACCACCCCCACCCCCACCCCTGCAAACAATTGGCATGTGGTTTGGGTGGCATTGTCACACCCTCGGCTTTCTAGATTAACCCAGTT
ACCTTTTAGCAGTGCCCCACTTCCCCAGTAGCAATGGTTCAGGGGTAGGCACCTGACCCAGACCAGACTACTGAGATAAAGATGTTTGCC
TAGGCTTTTTCAGGAGCAATTGAAGACATCTTGTTGGAGATAGTGTGCTGGGAGGAGTCACATTCTGAACTTGCTGCAGCTCGTTTTTCT
AATATAAAGGAACCAGCCTGAGGCAGTACCAGGGTGAGAGGGAGTCTATTGGAGCCCTTGGGAACTTCTGGATCAAATTGGACCTGAATT

>In-frame_ENST00000370280_ENST00000356940_TCGA-IN-A6RN_TMED5_chr1_93645610_-_RAB18_chr10_27821435_length(amino acids)=207AA_start in transcript=19_stop in transcript=642
MGDKIWLPFPVLLLAALPPVLLPGAAGFTPSLDSDFTFTLPAGQKECFYQPMPLKASLEIEYQDTAGQERFRTLTPSYYRGAQGVILVYD
VTRRDTFVKLDNWLNELETYCTRNDIVNMLVGNKIDKENREVDRNEGLKFARKHSMLFIEASAKTCDGVQCAFEELVEKIIQTPGLWESE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TMED5-RAB18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMED5-RAB18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMED5-RAB18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRAB18C1838625Warburg Sjo Fledelius syndrome2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneRAB18C3280203WARBURG MICRO SYNDROME 31GENOMICS_ENGLAND;UNIPROT