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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMEM117-KIF16B (FusionGDB2 ID:90920)

Fusion Gene Summary for TMEM117-KIF16B

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM117-KIF16B
Fusion gene ID: 90920
HgeneTgene
Gene symbol

TMEM117

KIF16B

Gene ID

84216

55614

Gene nametransmembrane protein 117kinesin family member 16B
Synonyms-C20orf23|KISC20ORF|SNX23
Cytomap

12q12

20p12.1

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 117kinesin-like protein KIF16Bkinesin motor proteinsorting nexin 23testis secretory sperm-binding protein Li 201a
Modification date2020031320200313
UniProtAcc.

Q96L93

Ensembl transtripts involved in fusion geneENST00000551577, ENST00000266534, 
ENST00000536799, ENST00000546978, 
ENST00000354981, ENST00000378003, 
ENST00000355755, ENST00000408042, 
Fusion gene scores* DoF score20 X 12 X 9=21607 X 5 X 6=210
# samples 218
** MAII scorelog2(21/2160*10)=-3.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM117 [Title/Abstract] AND KIF16B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMEM117(44537427)-KIF16B(16293063), # samples:3
Anticipated loss of major functional domain due to fusion event.TMEM117-KIF16B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TMEM117 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KIF16B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CQ-7072-01ATMEM117chr12

44338145

+KIF16Bchr20

16293063

-
ChimerDB4HNSCTCGA-CQ-7072TMEM117chr12

44537427

+KIF16Bchr20

16293063

-
ChimerDB4HNSCTCGA-CQ-7072TMEM117chr12

44338145

+KIF16Bchr20

16293063

-
ChimerDB4HNSCTCGA-CQ-7072TMEM117chr12

44537427

+KIF16Bchr20

16293063

-
ChimerDB4HNSCTCGA-CQ-7072-01ATMEM117chr12

44537427

-KIF16Bchr20

16293063

-


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Fusion Gene ORF analysis for TMEM117-KIF16B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000551577ENST00000354981TMEM117chr12

44338145

+KIF16Bchr20

16293063

-
Frame-shiftENST00000551577ENST00000378003TMEM117chr12

44338145

+KIF16Bchr20

16293063

-
Frame-shiftENST00000551577ENST00000355755TMEM117chr12

44338145

+KIF16Bchr20

16293063

-
5CDS-intronENST00000551577ENST00000408042TMEM117chr12

44338145

+KIF16Bchr20

16293063

-
Frame-shiftENST00000266534ENST00000354981TMEM117chr12

44338145

+KIF16Bchr20

16293063

-
Frame-shiftENST00000266534ENST00000378003TMEM117chr12

44338145

+KIF16Bchr20

16293063

-
Frame-shiftENST00000266534ENST00000355755TMEM117chr12

44338145

+KIF16Bchr20

16293063

-
5CDS-intronENST00000266534ENST00000408042TMEM117chr12

44338145

+KIF16Bchr20

16293063

-
In-frameENST00000536799ENST00000354981TMEM117chr12

44338145

+KIF16Bchr20

16293063

-
In-frameENST00000536799ENST00000378003TMEM117chr12

44338145

+KIF16Bchr20

16293063

-
In-frameENST00000536799ENST00000355755TMEM117chr12

44338145

+KIF16Bchr20

16293063

-
5CDS-intronENST00000536799ENST00000408042TMEM117chr12

44338145

+KIF16Bchr20

16293063

-
intron-3CDSENST00000546978ENST00000354981TMEM117chr12

44338145

+KIF16Bchr20

16293063

-
intron-3CDSENST00000546978ENST00000378003TMEM117chr12

44338145

+KIF16Bchr20

16293063

-
intron-3CDSENST00000546978ENST00000355755TMEM117chr12

44338145

+KIF16Bchr20

16293063

-
intron-intronENST00000546978ENST00000408042TMEM117chr12

44338145

+KIF16Bchr20

16293063

-
In-frameENST00000551577ENST00000354981TMEM117chr12

44537427

+KIF16Bchr20

16293063

-
In-frameENST00000551577ENST00000378003TMEM117chr12

44537427

+KIF16Bchr20

16293063

-
In-frameENST00000551577ENST00000355755TMEM117chr12

44537427

+KIF16Bchr20

16293063

-
5CDS-intronENST00000551577ENST00000408042TMEM117chr12

44537427

+KIF16Bchr20

16293063

-
In-frameENST00000266534ENST00000354981TMEM117chr12

44537427

+KIF16Bchr20

16293063

-
In-frameENST00000266534ENST00000378003TMEM117chr12

44537427

+KIF16Bchr20

16293063

-
In-frameENST00000266534ENST00000355755TMEM117chr12

44537427

+KIF16Bchr20

16293063

-
5CDS-intronENST00000266534ENST00000408042TMEM117chr12

44537427

+KIF16Bchr20

16293063

-
intron-3CDSENST00000536799ENST00000354981TMEM117chr12

44537427

+KIF16Bchr20

16293063

-
intron-3CDSENST00000536799ENST00000378003TMEM117chr12

44537427

+KIF16Bchr20

16293063

-
intron-3CDSENST00000536799ENST00000355755TMEM117chr12

44537427

+KIF16Bchr20

16293063

-
intron-intronENST00000536799ENST00000408042TMEM117chr12

44537427

+KIF16Bchr20

16293063

-
intron-3CDSENST00000546978ENST00000354981TMEM117chr12

44537427

+KIF16Bchr20

16293063

-
intron-3CDSENST00000546978ENST00000378003TMEM117chr12

44537427

+KIF16Bchr20

16293063

-
intron-3CDSENST00000546978ENST00000355755TMEM117chr12

44537427

+KIF16Bchr20

16293063

-
intron-intronENST00000546978ENST00000408042TMEM117chr12

44537427

+KIF16Bchr20

16293063

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000536799TMEM117chr1244338145+ENST00000354981KIF16Bchr2016293063-15901980440146
ENST00000536799TMEM117chr1244338145+ENST00000378003KIF16Bchr2016293063-15891980440146
ENST00000536799TMEM117chr1244338145+ENST00000355755KIF16Bchr2016293063-15891980440146
ENST00000551577TMEM117chr1244537427+ENST00000354981KIF16Bchr2016293063-2044652142894250
ENST00000551577TMEM117chr1244537427+ENST00000378003KIF16Bchr2016293063-2043652142894250
ENST00000551577TMEM117chr1244537427+ENST00000355755KIF16Bchr2016293063-2043652142894250
ENST00000266534TMEM117chr1244537427+ENST00000354981KIF16Bchr2016293063-2029637127879250
ENST00000266534TMEM117chr1244537427+ENST00000378003KIF16Bchr2016293063-2028637127879250
ENST00000266534TMEM117chr1244537427+ENST00000355755KIF16Bchr2016293063-2028637127879250

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000536799ENST00000354981TMEM117chr1244338145+KIF16Bchr2016293063-0.0778873040.92211276
ENST00000536799ENST00000378003TMEM117chr1244338145+KIF16Bchr2016293063-0.0776057540.9223943
ENST00000536799ENST00000355755TMEM117chr1244338145+KIF16Bchr2016293063-0.0776057540.9223943
ENST00000551577ENST00000354981TMEM117chr1244537427+KIF16Bchr2016293063-0.0032817870.9967182
ENST00000551577ENST00000378003TMEM117chr1244537427+KIF16Bchr2016293063-0.0032750930.9967249
ENST00000551577ENST00000355755TMEM117chr1244537427+KIF16Bchr2016293063-0.0032750930.9967249
ENST00000266534ENST00000354981TMEM117chr1244537427+KIF16Bchr2016293063-0.0041259880.995874
ENST00000266534ENST00000378003TMEM117chr1244537427+KIF16Bchr2016293063-0.0041212510.9958787
ENST00000266534ENST00000355755TMEM117chr1244537427+KIF16Bchr2016293063-0.0041212510.9958787

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Fusion Genomic Features for TMEM117-KIF16B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM117-KIF16B


check button Go to

FGviewer for the breakpoints of chr12:44338145-chr20:16293063

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KIF16B

Q96L93

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM117chr12:44338145chr20:16293063ENST00000266534+381_15136.66666666666666515.0Topological domainCytoplasmic
HgeneTMEM117chr12:44338145chr20:16293063ENST00000266534+3837_65136.66666666666666515.0Topological domainExtracellular
HgeneTMEM117chr12:44338145chr20:16293063ENST00000266534+3887_110136.66666666666666515.0Topological domainCytoplasmic
HgeneTMEM117chr12:44537427chr20:16293063ENST00000266534+48132_154170.0515.0Topological domainExtracellular
HgeneTMEM117chr12:44537427chr20:16293063ENST00000266534+481_15170.0515.0Topological domainCytoplasmic
HgeneTMEM117chr12:44537427chr20:16293063ENST00000266534+4837_65170.0515.0Topological domainExtracellular
HgeneTMEM117chr12:44537427chr20:16293063ENST00000266534+4887_110170.0515.0Topological domainCytoplasmic
HgeneTMEM117chr12:44338145chr20:16293063ENST00000266534+38111_131136.66666666666666515.0TransmembraneHelical
HgeneTMEM117chr12:44338145chr20:16293063ENST00000266534+3816_36136.66666666666666515.0TransmembraneHelical
HgeneTMEM117chr12:44338145chr20:16293063ENST00000266534+3866_86136.66666666666666515.0TransmembraneHelical
HgeneTMEM117chr12:44537427chr20:16293063ENST00000266534+48111_131170.0515.0TransmembraneHelical
HgeneTMEM117chr12:44537427chr20:16293063ENST00000266534+4816_36170.0515.0TransmembraneHelical
HgeneTMEM117chr12:44537427chr20:16293063ENST00000266534+4866_86170.0515.0TransmembraneHelical
TgeneKIF16Bchr12:44338145chr20:16293063ENST00000408042023370_42501393.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr12:44338145chr20:16293063ENST00000408042023595_88201393.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr12:44338145chr20:16293063ENST00000408042023936_108701393.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr12:44537427chr20:16293063ENST00000408042023370_42501393.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr12:44537427chr20:16293063ENST00000408042023595_88201393.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr12:44537427chr20:16293063ENST00000408042023936_108701393.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr12:44338145chr20:16293063ENST00000408042023597_107001393.0Compositional biasNote=Glu-rich
TgeneKIF16Bchr12:44537427chr20:16293063ENST00000408042023597_107001393.0Compositional biasNote=Glu-rich
TgeneKIF16Bchr12:44338145chr20:16293063ENST000004080420231182_129601393.0DomainPX
TgeneKIF16Bchr12:44338145chr20:16293063ENST000004080420233_35801393.0DomainKinesin motor
TgeneKIF16Bchr12:44338145chr20:16293063ENST00000408042023478_52901393.0DomainNote=FHA
TgeneKIF16Bchr12:44537427chr20:16293063ENST000004080420231182_129601393.0DomainPX
TgeneKIF16Bchr12:44537427chr20:16293063ENST000004080420233_35801393.0DomainKinesin motor
TgeneKIF16Bchr12:44537427chr20:16293063ENST00000408042023478_52901393.0DomainNote=FHA
TgeneKIF16Bchr12:44338145chr20:16293063ENST00000408042023102_10901393.0Nucleotide bindingATP
TgeneKIF16Bchr12:44537427chr20:16293063ENST00000408042023102_10901393.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM117chr12:44338145chr20:16293063ENST00000266534+38132_154136.66666666666666515.0Topological domainExtracellular
HgeneTMEM117chr12:44338145chr20:16293063ENST00000266534+38176_198136.66666666666666515.0Topological domainCytoplasmic
HgeneTMEM117chr12:44338145chr20:16293063ENST00000266534+38220_239136.66666666666666515.0Topological domainExtracellular
HgeneTMEM117chr12:44338145chr20:16293063ENST00000266534+38261_295136.66666666666666515.0Topological domainCytoplasmic
HgeneTMEM117chr12:44338145chr20:16293063ENST00000266534+38317_394136.66666666666666515.0Topological domainExtracellular
HgeneTMEM117chr12:44338145chr20:16293063ENST00000266534+38416_514136.66666666666666515.0Topological domainCytoplasmic
HgeneTMEM117chr12:44537427chr20:16293063ENST00000266534+48176_198170.0515.0Topological domainCytoplasmic
HgeneTMEM117chr12:44537427chr20:16293063ENST00000266534+48220_239170.0515.0Topological domainExtracellular
HgeneTMEM117chr12:44537427chr20:16293063ENST00000266534+48261_295170.0515.0Topological domainCytoplasmic
HgeneTMEM117chr12:44537427chr20:16293063ENST00000266534+48317_394170.0515.0Topological domainExtracellular
HgeneTMEM117chr12:44537427chr20:16293063ENST00000266534+48416_514170.0515.0Topological domainCytoplasmic
HgeneTMEM117chr12:44338145chr20:16293063ENST00000266534+38155_175136.66666666666666515.0TransmembraneHelical
HgeneTMEM117chr12:44338145chr20:16293063ENST00000266534+38199_219136.66666666666666515.0TransmembraneHelical
HgeneTMEM117chr12:44338145chr20:16293063ENST00000266534+38240_260136.66666666666666515.0TransmembraneHelical
HgeneTMEM117chr12:44338145chr20:16293063ENST00000266534+38296_316136.66666666666666515.0TransmembraneHelical
HgeneTMEM117chr12:44338145chr20:16293063ENST00000266534+38395_415136.66666666666666515.0TransmembraneHelical
HgeneTMEM117chr12:44537427chr20:16293063ENST00000266534+48155_175170.0515.0TransmembraneHelical
HgeneTMEM117chr12:44537427chr20:16293063ENST00000266534+48199_219170.0515.0TransmembraneHelical
HgeneTMEM117chr12:44537427chr20:16293063ENST00000266534+48240_260170.0515.0TransmembraneHelical
HgeneTMEM117chr12:44537427chr20:16293063ENST00000266534+48296_316170.0515.0TransmembraneHelical
HgeneTMEM117chr12:44537427chr20:16293063ENST00000266534+48395_415170.0515.0TransmembraneHelical
TgeneKIF16Bchr12:44338145chr20:16293063ENST000003549812326370_4251237.01318.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr12:44338145chr20:16293063ENST000003549812326595_8821237.01318.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr12:44338145chr20:16293063ENST000003549812326936_10871237.01318.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr12:44338145chr20:16293063ENST000003557552225370_4251207.01288.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr12:44338145chr20:16293063ENST000003557552225595_8821207.01288.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr12:44338145chr20:16293063ENST000003557552225936_10871207.01288.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr12:44537427chr20:16293063ENST000003549812326370_4251237.01318.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr12:44537427chr20:16293063ENST000003549812326595_8821237.01318.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr12:44537427chr20:16293063ENST000003549812326936_10871237.01318.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr12:44537427chr20:16293063ENST000003557552225370_4251207.01288.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr12:44537427chr20:16293063ENST000003557552225595_8821207.01288.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr12:44537427chr20:16293063ENST000003557552225936_10871207.01288.0Coiled coilOntology_term=ECO:0000255
TgeneKIF16Bchr12:44338145chr20:16293063ENST000003549812326597_10701237.01318.0Compositional biasNote=Glu-rich
TgeneKIF16Bchr12:44338145chr20:16293063ENST000003557552225597_10701207.01288.0Compositional biasNote=Glu-rich
TgeneKIF16Bchr12:44537427chr20:16293063ENST000003549812326597_10701237.01318.0Compositional biasNote=Glu-rich
TgeneKIF16Bchr12:44537427chr20:16293063ENST000003557552225597_10701207.01288.0Compositional biasNote=Glu-rich
TgeneKIF16Bchr12:44338145chr20:16293063ENST0000035498123261182_12961237.01318.0DomainPX
TgeneKIF16Bchr12:44338145chr20:16293063ENST0000035498123263_3581237.01318.0DomainKinesin motor
TgeneKIF16Bchr12:44338145chr20:16293063ENST000003549812326478_5291237.01318.0DomainNote=FHA
TgeneKIF16Bchr12:44338145chr20:16293063ENST0000035575522251182_12961207.01288.0DomainPX
TgeneKIF16Bchr12:44338145chr20:16293063ENST0000035575522253_3581207.01288.0DomainKinesin motor
TgeneKIF16Bchr12:44338145chr20:16293063ENST000003557552225478_5291207.01288.0DomainNote=FHA
TgeneKIF16Bchr12:44537427chr20:16293063ENST0000035498123261182_12961237.01318.0DomainPX
TgeneKIF16Bchr12:44537427chr20:16293063ENST0000035498123263_3581237.01318.0DomainKinesin motor
TgeneKIF16Bchr12:44537427chr20:16293063ENST000003549812326478_5291237.01318.0DomainNote=FHA
TgeneKIF16Bchr12:44537427chr20:16293063ENST0000035575522251182_12961207.01288.0DomainPX
TgeneKIF16Bchr12:44537427chr20:16293063ENST0000035575522253_3581207.01288.0DomainKinesin motor
TgeneKIF16Bchr12:44537427chr20:16293063ENST000003557552225478_5291207.01288.0DomainNote=FHA
TgeneKIF16Bchr12:44338145chr20:16293063ENST000003549812326102_1091237.01318.0Nucleotide bindingATP
TgeneKIF16Bchr12:44338145chr20:16293063ENST000003557552225102_1091207.01288.0Nucleotide bindingATP
TgeneKIF16Bchr12:44537427chr20:16293063ENST000003549812326102_1091237.01318.0Nucleotide bindingATP
TgeneKIF16Bchr12:44537427chr20:16293063ENST000003557552225102_1091207.01288.0Nucleotide bindingATP


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Fusion Gene Sequence for TMEM117-KIF16B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000536799_ENST00000354981_TCGA-CQ-7072-01A_TMEM117_chr12_44338145_+_KIF16B_chr20_16293063_length(transcript)=1590nt_BP=198nt
ATGGCTACTTGCCATTCTCACAGGACTAATAGCTGGCAAATTTCTGTTCCATCAGCGTTTGTTTGGTCAGTTGCTCCGATTAAAAATGTT
TCGAGAAGATCATGGGTCGTGGATGACAATGTTCTTCAGCACAATTCTCTTTCTCTTCATATTTTCTCACATATACAACACGATTCTTCT
AATGGATGGGAACATGGGCTTGCTGCCCTTGAATTTCCTCCAAAGAAACTATTTGGAAATAAGGATGAACGTGTGATTGCTGAGAGACGA
AGTCACTTAGAGAAATACCTCAGGGACTTTTTCAGCGTGATGCTCCAGTCCGCAACATCTCCCCTCCACATCAACAAAGTGGGACTGACT
CTCTCGAAACATACCATTTGTGAGTTTTCACCATTCTTCAAGAAAGGAGTCTTTGACTACAGCAGCCACGGGACGGGGTAGAGCCAGGGG
TGATGGAGGAACCACCACAGCAGTGCCTTCTCGTCGAAGCGGGCTCCGATGCAGGGCAGCTCCCCCATGCGAGGATCCGGGTCTGCCTCC
TCCTGCTGAAGACAGACATGCAGCAGCGGGCCCGGGCCACCTCACGTTTCCATACCTAGTGCCTGAGTTTGGGGATGGGATGCTCTGCCT
GCTGATGTGGCCCTGACAGGCAGCCGTTACCGTTCCATTGCGGTTGAACGTGGCCTTTTCCCACAGTGCTTCCTTCTCACTGCGCAGCAA
AGTTCGTCCCCTGTGGCAAGATAGATGTGGTTGGGCCATCGTGGGTTCCCTGAGCCCAGCCAGCCTGGGACCTCCCAAAGTGGGTGGCTT
ACCAGACCACCCTTAAATGACTTTCATCTGGTTTCCTCTTTCACCAAAATATACTCGTATTTTTTATATTTCTTCCATGTGGCTGGCTAT
ATTCCAAGAAAAGCATTTTAAATTATTTCATTGTATTTTTTTCTTTTTTTCCCTCATTTGAATCAGAACTTTTATATAAAACCCAAACAC
TGATGTTTACACAGAATTTCATATTCTGCAAAAGGGATTTTTTGATCCAATCATGACTGTAGTCTTCCATGCTTGACAAATTGGATGTAG
ACAACATTACTTAAAACTTCTATAAATCCCTACAATTAGGATATTTATTTAACCTTGAATATTCAAGAACATTCTCCCAAATCTAAATGG
CTACTGTGCATTCTTGAGCTTTTTCTGCTAAGCACAAAATGAACGCAAAGCTAAATGCATATTTTTAAGTATTATTCACATTTTTTGTTA
CAGAATCTATTGGATCTTTGGCTGGAAAACTAGAATTTATAGCAGTTTATTAATGATACCTTAAATTACTCAGGACTTAATGTAGCATTG
CACTTCTGTGTACAGTAAAACTGCTTTGTTTTACTAAAGAGAAAAATGTGAGTGGAAAAAATATGTATGTGGTATATACTCAAATGTATA
TAATTCTATCTATAGATTTATATATGTATACATTCTGTACAGTAGTTCCATCAAAATATGTAATAATTCACACCAATTTTATTAAATGTA

>In-frame_ENST00000536799_ENST00000354981_TCGA-CQ-7072-01A_TMEM117_chr12_44338145_+_KIF16B_chr20_16293063_length(amino acids)=146AA_start in transcript=0_stop in transcript=440
MATCHSHRTNSWQISVPSAFVWSVAPIKNVSRRSWVVDDNVLQHNSLSLHIFSHIQHDSSNGWEHGLAALEFPPKKLFGNKDERVIAERR

--------------------------------------------------------------
>In-frame_ENST00000536799_ENST00000378003_TCGA-CQ-7072-01A_TMEM117_chr12_44338145_+_KIF16B_chr20_16293063_length(transcript)=1589nt_BP=198nt
ATGGCTACTTGCCATTCTCACAGGACTAATAGCTGGCAAATTTCTGTTCCATCAGCGTTTGTTTGGTCAGTTGCTCCGATTAAAAATGTT
TCGAGAAGATCATGGGTCGTGGATGACAATGTTCTTCAGCACAATTCTCTTTCTCTTCATATTTTCTCACATATACAACACGATTCTTCT
AATGGATGGGAACATGGGCTTGCTGCCCTTGAATTTCCTCCAAAGAAACTATTTGGAAATAAGGATGAACGTGTGATTGCTGAGAGACGA
AGTCACTTAGAGAAATACCTCAGGGACTTTTTCAGCGTGATGCTCCAGTCCGCAACATCTCCCCTCCACATCAACAAAGTGGGACTGACT
CTCTCGAAACATACCATTTGTGAGTTTTCACCATTCTTCAAGAAAGGAGTCTTTGACTACAGCAGCCACGGGACGGGGTAGAGCCAGGGG
TGATGGAGGAACCACCACAGCAGTGCCTTCTCGTCGAAGCGGGCTCCGATGCAGGGCAGCTCCCCCATGCGAGGATCCGGGTCTGCCTCC
TCCTGCTGAAGACAGACATGCAGCAGCGGGCCCGGGCCACCTCACGTTTCCATACCTAGTGCCTGAGTTTGGGGATGGGATGCTCTGCCT
GCTGATGTGGCCCTGACAGGCAGCCGTTACCGTTCCATTGCGGTTGAACGTGGCCTTTTCCCACAGTGCTTCCTTCTCACTGCGCAGCAA
AGTTCGTCCCCTGTGGCAAGATAGATGTGGTTGGGCCATCGTGGGTTCCCTGAGCCCAGCCAGCCTGGGACCTCCCAAAGTGGGTGGCTT
ACCAGACCACCCTTAAATGACTTTCATCTGGTTTCCTCTTTCACCAAAATATACTCGTATTTTTTATATTTCTTCCATGTGGCTGGCTAT
ATTCCAAGAAAAGCATTTTAAATTATTTCATTGTATTTTTTTCTTTTTTTCCCTCATTTGAATCAGAACTTTTATATAAAACCCAAACAC
TGATGTTTACACAGAATTTCATATTCTGCAAAAGGGATTTTTTGATCCAATCATGACTGTAGTCTTCCATGCTTGACAAATTGGATGTAG
ACAACATTACTTAAAACTTCTATAAATCCCTACAATTAGGATATTTATTTAACCTTGAATATTCAAGAACATTCTCCCAAATCTAAATGG
CTACTGTGCATTCTTGAGCTTTTTCTGCTAAGCACAAAATGAACGCAAAGCTAAATGCATATTTTTAAGTATTATTCACATTTTTTGTTA
CAGAATCTATTGGATCTTTGGCTGGAAAACTAGAATTTATAGCAGTTTATTAATGATACCTTAAATTACTCAGGACTTAATGTAGCATTG
CACTTCTGTGTACAGTAAAACTGCTTTGTTTTACTAAAGAGAAAAATGTGAGTGGAAAAAATATGTATGTGGTATATACTCAAATGTATA
TAATTCTATCTATAGATTTATATATGTATACATTCTGTACAGTAGTTCCATCAAAATATGTAATAATTCACACCAATTTTATTAAATGTA

>In-frame_ENST00000536799_ENST00000378003_TCGA-CQ-7072-01A_TMEM117_chr12_44338145_+_KIF16B_chr20_16293063_length(amino acids)=146AA_start in transcript=0_stop in transcript=440
MATCHSHRTNSWQISVPSAFVWSVAPIKNVSRRSWVVDDNVLQHNSLSLHIFSHIQHDSSNGWEHGLAALEFPPKKLFGNKDERVIAERR

--------------------------------------------------------------
>In-frame_ENST00000536799_ENST00000355755_TCGA-CQ-7072-01A_TMEM117_chr12_44338145_+_KIF16B_chr20_16293063_length(transcript)=1589nt_BP=198nt
ATGGCTACTTGCCATTCTCACAGGACTAATAGCTGGCAAATTTCTGTTCCATCAGCGTTTGTTTGGTCAGTTGCTCCGATTAAAAATGTT
TCGAGAAGATCATGGGTCGTGGATGACAATGTTCTTCAGCACAATTCTCTTTCTCTTCATATTTTCTCACATATACAACACGATTCTTCT
AATGGATGGGAACATGGGCTTGCTGCCCTTGAATTTCCTCCAAAGAAACTATTTGGAAATAAGGATGAACGTGTGATTGCTGAGAGACGA
AGTCACTTAGAGAAATACCTCAGGGACTTTTTCAGCGTGATGCTCCAGTCCGCAACATCTCCCCTCCACATCAACAAAGTGGGACTGACT
CTCTCGAAACATACCATTTGTGAGTTTTCACCATTCTTCAAGAAAGGAGTCTTTGACTACAGCAGCCACGGGACGGGGTAGAGCCAGGGG
TGATGGAGGAACCACCACAGCAGTGCCTTCTCGTCGAAGCGGGCTCCGATGCAGGGCAGCTCCCCCATGCGAGGATCCGGGTCTGCCTCC
TCCTGCTGAAGACAGACATGCAGCAGCGGGCCCGGGCCACCTCACGTTTCCATACCTAGTGCCTGAGTTTGGGGATGGGATGCTCTGCCT
GCTGATGTGGCCCTGACAGGCAGCCGTTACCGTTCCATTGCGGTTGAACGTGGCCTTTTCCCACAGTGCTTCCTTCTCACTGCGCAGCAA
AGTTCGTCCCCTGTGGCAAGATAGATGTGGTTGGGCCATCGTGGGTTCCCTGAGCCCAGCCAGCCTGGGACCTCCCAAAGTGGGTGGCTT
ACCAGACCACCCTTAAATGACTTTCATCTGGTTTCCTCTTTCACCAAAATATACTCGTATTTTTTATATTTCTTCCATGTGGCTGGCTAT
ATTCCAAGAAAAGCATTTTAAATTATTTCATTGTATTTTTTTCTTTTTTTCCCTCATTTGAATCAGAACTTTTATATAAAACCCAAACAC
TGATGTTTACACAGAATTTCATATTCTGCAAAAGGGATTTTTTGATCCAATCATGACTGTAGTCTTCCATGCTTGACAAATTGGATGTAG
ACAACATTACTTAAAACTTCTATAAATCCCTACAATTAGGATATTTATTTAACCTTGAATATTCAAGAACATTCTCCCAAATCTAAATGG
CTACTGTGCATTCTTGAGCTTTTTCTGCTAAGCACAAAATGAACGCAAAGCTAAATGCATATTTTTAAGTATTATTCACATTTTTTGTTA
CAGAATCTATTGGATCTTTGGCTGGAAAACTAGAATTTATAGCAGTTTATTAATGATACCTTAAATTACTCAGGACTTAATGTAGCATTG
CACTTCTGTGTACAGTAAAACTGCTTTGTTTTACTAAAGAGAAAAATGTGAGTGGAAAAAATATGTATGTGGTATATACTCAAATGTATA
TAATTCTATCTATAGATTTATATATGTATACATTCTGTACAGTAGTTCCATCAAAATATGTAATAATTCACACCAATTTTATTAAATGTA

>In-frame_ENST00000536799_ENST00000355755_TCGA-CQ-7072-01A_TMEM117_chr12_44338145_+_KIF16B_chr20_16293063_length(amino acids)=146AA_start in transcript=0_stop in transcript=440
MATCHSHRTNSWQISVPSAFVWSVAPIKNVSRRSWVVDDNVLQHNSLSLHIFSHIQHDSSNGWEHGLAALEFPPKKLFGNKDERVIAERR

--------------------------------------------------------------
>In-frame_ENST00000551577_ENST00000354981_TCGA-CQ-7072_TMEM117_chr12_44537427_+_KIF16B_chr20_16293063_length(transcript)=2044nt_BP=652nt
CGACGCCGCCGGCCCGTCTCGCCGCGCTTCCCAGCGAGGCCGCCGGCGCGCCGAGGGCTGTGCTCGACCGCGAATCCCGTGTGCAGTCGC
CCCGCGCCCCGCGCGACCCTTCGGGTAAACTACGAACTGGGAGTTCTGAAGAATGGGTAAAGACTTTCGTTACTATTTCCAGCATCCCTG
GTCTCGCATGATTGTGGCTTACTTGGTGATCTTCTTTAACTTCTTAATATTTGCGGAGGACCCAGTTTCTCATAGCCAAACAGAAGCCAA
TGTTATTGTTGTTGGAAACTGTTTTTCATTTGTTACAAATAAATACCCTAGAGGAGTTGGCTGGAGGATTTTGAAGGTGCTTCTATGGCT
ACTTGCCATTCTCACAGGACTAATAGCTGGCAAATTTCTGTTCCATCAGCGTTTGTTTGGTCAGTTGCTCCGATTAAAAATGTTTCGAGA
AGATCATGGGTCGTGGATGACAATGTTCTTCAGCACAATTCTCTTTCTCTTCATATTTTCTCACATATACAACACGATTCTTCTAATGGA
TGGGAACATGGGAGCATATATCATTACAGACTATATGGGCATCCGAAATGAAAGTTTCATGAAATTAGCTGCAGTAGGGACCTGGATGGG
GGACTTTGTCACAGCTTGGATGCTTGCTGCCCTTGAATTTCCTCCAAAGAAACTATTTGGAAATAAGGATGAACGTGTGATTGCTGAGAG
ACGAAGTCACTTAGAGAAATACCTCAGGGACTTTTTCAGCGTGATGCTCCAGTCCGCAACATCTCCCCTCCACATCAACAAAGTGGGACT
GACTCTCTCGAAACATACCATTTGTGAGTTTTCACCATTCTTCAAGAAAGGAGTCTTTGACTACAGCAGCCACGGGACGGGGTAGAGCCA
GGGGTGATGGAGGAACCACCACAGCAGTGCCTTCTCGTCGAAGCGGGCTCCGATGCAGGGCAGCTCCCCCATGCGAGGATCCGGGTCTGC
CTCCTCCTGCTGAAGACAGACATGCAGCAGCGGGCCCGGGCCACCTCACGTTTCCATACCTAGTGCCTGAGTTTGGGGATGGGATGCTCT
GCCTGCTGATGTGGCCCTGACAGGCAGCCGTTACCGTTCCATTGCGGTTGAACGTGGCCTTTTCCCACAGTGCTTCCTTCTCACTGCGCA
GCAAAGTTCGTCCCCTGTGGCAAGATAGATGTGGTTGGGCCATCGTGGGTTCCCTGAGCCCAGCCAGCCTGGGACCTCCCAAAGTGGGTG
GCTTACCAGACCACCCTTAAATGACTTTCATCTGGTTTCCTCTTTCACCAAAATATACTCGTATTTTTTATATTTCTTCCATGTGGCTGG
CTATATTCCAAGAAAAGCATTTTAAATTATTTCATTGTATTTTTTTCTTTTTTTCCCTCATTTGAATCAGAACTTTTATATAAAACCCAA
ACACTGATGTTTACACAGAATTTCATATTCTGCAAAAGGGATTTTTTGATCCAATCATGACTGTAGTCTTCCATGCTTGACAAATTGGAT
GTAGACAACATTACTTAAAACTTCTATAAATCCCTACAATTAGGATATTTATTTAACCTTGAATATTCAAGAACATTCTCCCAAATCTAA
ATGGCTACTGTGCATTCTTGAGCTTTTTCTGCTAAGCACAAAATGAACGCAAAGCTAAATGCATATTTTTAAGTATTATTCACATTTTTT
GTTACAGAATCTATTGGATCTTTGGCTGGAAAACTAGAATTTATAGCAGTTTATTAATGATACCTTAAATTACTCAGGACTTAATGTAGC
ATTGCACTTCTGTGTACAGTAAAACTGCTTTGTTTTACTAAAGAGAAAAATGTGAGTGGAAAAAATATGTATGTGGTATATACTCAAATG
TATATAATTCTATCTATAGATTTATATATGTATACATTCTGTACAGTAGTTCCATCAAAATATGTAATAATTCACACCAATTTTATTAAA

>In-frame_ENST00000551577_ENST00000354981_TCGA-CQ-7072_TMEM117_chr12_44537427_+_KIF16B_chr20_16293063_length(amino acids)=250AA_start in transcript=142_stop in transcript=894
MGKDFRYYFQHPWSRMIVAYLVIFFNFLIFAEDPVSHSQTEANVIVVGNCFSFVTNKYPRGVGWRILKVLLWLLAILTGLIAGKFLFHQR
LFGQLLRLKMFREDHGSWMTMFFSTILFLFIFSHIYNTILLMDGNMGAYIITDYMGIRNESFMKLAAVGTWMGDFVTAWMLAALEFPPKK

--------------------------------------------------------------
>In-frame_ENST00000551577_ENST00000378003_TCGA-CQ-7072_TMEM117_chr12_44537427_+_KIF16B_chr20_16293063_length(transcript)=2043nt_BP=652nt
CGACGCCGCCGGCCCGTCTCGCCGCGCTTCCCAGCGAGGCCGCCGGCGCGCCGAGGGCTGTGCTCGACCGCGAATCCCGTGTGCAGTCGC
CCCGCGCCCCGCGCGACCCTTCGGGTAAACTACGAACTGGGAGTTCTGAAGAATGGGTAAAGACTTTCGTTACTATTTCCAGCATCCCTG
GTCTCGCATGATTGTGGCTTACTTGGTGATCTTCTTTAACTTCTTAATATTTGCGGAGGACCCAGTTTCTCATAGCCAAACAGAAGCCAA
TGTTATTGTTGTTGGAAACTGTTTTTCATTTGTTACAAATAAATACCCTAGAGGAGTTGGCTGGAGGATTTTGAAGGTGCTTCTATGGCT
ACTTGCCATTCTCACAGGACTAATAGCTGGCAAATTTCTGTTCCATCAGCGTTTGTTTGGTCAGTTGCTCCGATTAAAAATGTTTCGAGA
AGATCATGGGTCGTGGATGACAATGTTCTTCAGCACAATTCTCTTTCTCTTCATATTTTCTCACATATACAACACGATTCTTCTAATGGA
TGGGAACATGGGAGCATATATCATTACAGACTATATGGGCATCCGAAATGAAAGTTTCATGAAATTAGCTGCAGTAGGGACCTGGATGGG
GGACTTTGTCACAGCTTGGATGCTTGCTGCCCTTGAATTTCCTCCAAAGAAACTATTTGGAAATAAGGATGAACGTGTGATTGCTGAGAG
ACGAAGTCACTTAGAGAAATACCTCAGGGACTTTTTCAGCGTGATGCTCCAGTCCGCAACATCTCCCCTCCACATCAACAAAGTGGGACT
GACTCTCTCGAAACATACCATTTGTGAGTTTTCACCATTCTTCAAGAAAGGAGTCTTTGACTACAGCAGCCACGGGACGGGGTAGAGCCA
GGGGTGATGGAGGAACCACCACAGCAGTGCCTTCTCGTCGAAGCGGGCTCCGATGCAGGGCAGCTCCCCCATGCGAGGATCCGGGTCTGC
CTCCTCCTGCTGAAGACAGACATGCAGCAGCGGGCCCGGGCCACCTCACGTTTCCATACCTAGTGCCTGAGTTTGGGGATGGGATGCTCT
GCCTGCTGATGTGGCCCTGACAGGCAGCCGTTACCGTTCCATTGCGGTTGAACGTGGCCTTTTCCCACAGTGCTTCCTTCTCACTGCGCA
GCAAAGTTCGTCCCCTGTGGCAAGATAGATGTGGTTGGGCCATCGTGGGTTCCCTGAGCCCAGCCAGCCTGGGACCTCCCAAAGTGGGTG
GCTTACCAGACCACCCTTAAATGACTTTCATCTGGTTTCCTCTTTCACCAAAATATACTCGTATTTTTTATATTTCTTCCATGTGGCTGG
CTATATTCCAAGAAAAGCATTTTAAATTATTTCATTGTATTTTTTTCTTTTTTTCCCTCATTTGAATCAGAACTTTTATATAAAACCCAA
ACACTGATGTTTACACAGAATTTCATATTCTGCAAAAGGGATTTTTTGATCCAATCATGACTGTAGTCTTCCATGCTTGACAAATTGGAT
GTAGACAACATTACTTAAAACTTCTATAAATCCCTACAATTAGGATATTTATTTAACCTTGAATATTCAAGAACATTCTCCCAAATCTAA
ATGGCTACTGTGCATTCTTGAGCTTTTTCTGCTAAGCACAAAATGAACGCAAAGCTAAATGCATATTTTTAAGTATTATTCACATTTTTT
GTTACAGAATCTATTGGATCTTTGGCTGGAAAACTAGAATTTATAGCAGTTTATTAATGATACCTTAAATTACTCAGGACTTAATGTAGC
ATTGCACTTCTGTGTACAGTAAAACTGCTTTGTTTTACTAAAGAGAAAAATGTGAGTGGAAAAAATATGTATGTGGTATATACTCAAATG
TATATAATTCTATCTATAGATTTATATATGTATACATTCTGTACAGTAGTTCCATCAAAATATGTAATAATTCACACCAATTTTATTAAA

>In-frame_ENST00000551577_ENST00000378003_TCGA-CQ-7072_TMEM117_chr12_44537427_+_KIF16B_chr20_16293063_length(amino acids)=250AA_start in transcript=142_stop in transcript=894
MGKDFRYYFQHPWSRMIVAYLVIFFNFLIFAEDPVSHSQTEANVIVVGNCFSFVTNKYPRGVGWRILKVLLWLLAILTGLIAGKFLFHQR
LFGQLLRLKMFREDHGSWMTMFFSTILFLFIFSHIYNTILLMDGNMGAYIITDYMGIRNESFMKLAAVGTWMGDFVTAWMLAALEFPPKK

--------------------------------------------------------------
>In-frame_ENST00000551577_ENST00000355755_TCGA-CQ-7072_TMEM117_chr12_44537427_+_KIF16B_chr20_16293063_length(transcript)=2043nt_BP=652nt
CGACGCCGCCGGCCCGTCTCGCCGCGCTTCCCAGCGAGGCCGCCGGCGCGCCGAGGGCTGTGCTCGACCGCGAATCCCGTGTGCAGTCGC
CCCGCGCCCCGCGCGACCCTTCGGGTAAACTACGAACTGGGAGTTCTGAAGAATGGGTAAAGACTTTCGTTACTATTTCCAGCATCCCTG
GTCTCGCATGATTGTGGCTTACTTGGTGATCTTCTTTAACTTCTTAATATTTGCGGAGGACCCAGTTTCTCATAGCCAAACAGAAGCCAA
TGTTATTGTTGTTGGAAACTGTTTTTCATTTGTTACAAATAAATACCCTAGAGGAGTTGGCTGGAGGATTTTGAAGGTGCTTCTATGGCT
ACTTGCCATTCTCACAGGACTAATAGCTGGCAAATTTCTGTTCCATCAGCGTTTGTTTGGTCAGTTGCTCCGATTAAAAATGTTTCGAGA
AGATCATGGGTCGTGGATGACAATGTTCTTCAGCACAATTCTCTTTCTCTTCATATTTTCTCACATATACAACACGATTCTTCTAATGGA
TGGGAACATGGGAGCATATATCATTACAGACTATATGGGCATCCGAAATGAAAGTTTCATGAAATTAGCTGCAGTAGGGACCTGGATGGG
GGACTTTGTCACAGCTTGGATGCTTGCTGCCCTTGAATTTCCTCCAAAGAAACTATTTGGAAATAAGGATGAACGTGTGATTGCTGAGAG
ACGAAGTCACTTAGAGAAATACCTCAGGGACTTTTTCAGCGTGATGCTCCAGTCCGCAACATCTCCCCTCCACATCAACAAAGTGGGACT
GACTCTCTCGAAACATACCATTTGTGAGTTTTCACCATTCTTCAAGAAAGGAGTCTTTGACTACAGCAGCCACGGGACGGGGTAGAGCCA
GGGGTGATGGAGGAACCACCACAGCAGTGCCTTCTCGTCGAAGCGGGCTCCGATGCAGGGCAGCTCCCCCATGCGAGGATCCGGGTCTGC
CTCCTCCTGCTGAAGACAGACATGCAGCAGCGGGCCCGGGCCACCTCACGTTTCCATACCTAGTGCCTGAGTTTGGGGATGGGATGCTCT
GCCTGCTGATGTGGCCCTGACAGGCAGCCGTTACCGTTCCATTGCGGTTGAACGTGGCCTTTTCCCACAGTGCTTCCTTCTCACTGCGCA
GCAAAGTTCGTCCCCTGTGGCAAGATAGATGTGGTTGGGCCATCGTGGGTTCCCTGAGCCCAGCCAGCCTGGGACCTCCCAAAGTGGGTG
GCTTACCAGACCACCCTTAAATGACTTTCATCTGGTTTCCTCTTTCACCAAAATATACTCGTATTTTTTATATTTCTTCCATGTGGCTGG
CTATATTCCAAGAAAAGCATTTTAAATTATTTCATTGTATTTTTTTCTTTTTTTCCCTCATTTGAATCAGAACTTTTATATAAAACCCAA
ACACTGATGTTTACACAGAATTTCATATTCTGCAAAAGGGATTTTTTGATCCAATCATGACTGTAGTCTTCCATGCTTGACAAATTGGAT
GTAGACAACATTACTTAAAACTTCTATAAATCCCTACAATTAGGATATTTATTTAACCTTGAATATTCAAGAACATTCTCCCAAATCTAA
ATGGCTACTGTGCATTCTTGAGCTTTTTCTGCTAAGCACAAAATGAACGCAAAGCTAAATGCATATTTTTAAGTATTATTCACATTTTTT
GTTACAGAATCTATTGGATCTTTGGCTGGAAAACTAGAATTTATAGCAGTTTATTAATGATACCTTAAATTACTCAGGACTTAATGTAGC
ATTGCACTTCTGTGTACAGTAAAACTGCTTTGTTTTACTAAAGAGAAAAATGTGAGTGGAAAAAATATGTATGTGGTATATACTCAAATG
TATATAATTCTATCTATAGATTTATATATGTATACATTCTGTACAGTAGTTCCATCAAAATATGTAATAATTCACACCAATTTTATTAAA

>In-frame_ENST00000551577_ENST00000355755_TCGA-CQ-7072_TMEM117_chr12_44537427_+_KIF16B_chr20_16293063_length(amino acids)=250AA_start in transcript=142_stop in transcript=894
MGKDFRYYFQHPWSRMIVAYLVIFFNFLIFAEDPVSHSQTEANVIVVGNCFSFVTNKYPRGVGWRILKVLLWLLAILTGLIAGKFLFHQR
LFGQLLRLKMFREDHGSWMTMFFSTILFLFIFSHIYNTILLMDGNMGAYIITDYMGIRNESFMKLAAVGTWMGDFVTAWMLAALEFPPKK

--------------------------------------------------------------
>In-frame_ENST00000266534_ENST00000354981_TCGA-CQ-7072_TMEM117_chr12_44537427_+_KIF16B_chr20_16293063_length(transcript)=2029nt_BP=637nt
GTCTCGCCGCGCTTCCCAGCGAGGCCGCCGGCGCGCCGAGGGCTGTGCTCGACCGCGAATCCCGTGTGCAGTCGCCCCGCGCCCCGCGCG
ACCCTTCGGGTAAACTACGAACTGGGAGTTCTGAAGAATGGGTAAAGACTTTCGTTACTATTTCCAGCATCCCTGGTCTCGCATGATTGT
GGCTTACTTGGTGATCTTCTTTAACTTCTTAATATTTGCGGAGGACCCAGTTTCTCATAGCCAAACAGAAGCCAATGTTATTGTTGTTGG
AAACTGTTTTTCATTTGTTACAAATAAATACCCTAGAGGAGTTGGCTGGAGGATTTTGAAGGTGCTTCTATGGCTACTTGCCATTCTCAC
AGGACTAATAGCTGGCAAATTTCTGTTCCATCAGCGTTTGTTTGGTCAGTTGCTCCGATTAAAAATGTTTCGAGAAGATCATGGGTCGTG
GATGACAATGTTCTTCAGCACAATTCTCTTTCTCTTCATATTTTCTCACATATACAACACGATTCTTCTAATGGATGGGAACATGGGAGC
ATATATCATTACAGACTATATGGGCATCCGAAATGAAAGTTTCATGAAATTAGCTGCAGTAGGGACCTGGATGGGGGACTTTGTCACAGC
TTGGATGCTTGCTGCCCTTGAATTTCCTCCAAAGAAACTATTTGGAAATAAGGATGAACGTGTGATTGCTGAGAGACGAAGTCACTTAGA
GAAATACCTCAGGGACTTTTTCAGCGTGATGCTCCAGTCCGCAACATCTCCCCTCCACATCAACAAAGTGGGACTGACTCTCTCGAAACA
TACCATTTGTGAGTTTTCACCATTCTTCAAGAAAGGAGTCTTTGACTACAGCAGCCACGGGACGGGGTAGAGCCAGGGGTGATGGAGGAA
CCACCACAGCAGTGCCTTCTCGTCGAAGCGGGCTCCGATGCAGGGCAGCTCCCCCATGCGAGGATCCGGGTCTGCCTCCTCCTGCTGAAG
ACAGACATGCAGCAGCGGGCCCGGGCCACCTCACGTTTCCATACCTAGTGCCTGAGTTTGGGGATGGGATGCTCTGCCTGCTGATGTGGC
CCTGACAGGCAGCCGTTACCGTTCCATTGCGGTTGAACGTGGCCTTTTCCCACAGTGCTTCCTTCTCACTGCGCAGCAAAGTTCGTCCCC
TGTGGCAAGATAGATGTGGTTGGGCCATCGTGGGTTCCCTGAGCCCAGCCAGCCTGGGACCTCCCAAAGTGGGTGGCTTACCAGACCACC
CTTAAATGACTTTCATCTGGTTTCCTCTTTCACCAAAATATACTCGTATTTTTTATATTTCTTCCATGTGGCTGGCTATATTCCAAGAAA
AGCATTTTAAATTATTTCATTGTATTTTTTTCTTTTTTTCCCTCATTTGAATCAGAACTTTTATATAAAACCCAAACACTGATGTTTACA
CAGAATTTCATATTCTGCAAAAGGGATTTTTTGATCCAATCATGACTGTAGTCTTCCATGCTTGACAAATTGGATGTAGACAACATTACT
TAAAACTTCTATAAATCCCTACAATTAGGATATTTATTTAACCTTGAATATTCAAGAACATTCTCCCAAATCTAAATGGCTACTGTGCAT
TCTTGAGCTTTTTCTGCTAAGCACAAAATGAACGCAAAGCTAAATGCATATTTTTAAGTATTATTCACATTTTTTGTTACAGAATCTATT
GGATCTTTGGCTGGAAAACTAGAATTTATAGCAGTTTATTAATGATACCTTAAATTACTCAGGACTTAATGTAGCATTGCACTTCTGTGT
ACAGTAAAACTGCTTTGTTTTACTAAAGAGAAAAATGTGAGTGGAAAAAATATGTATGTGGTATATACTCAAATGTATATAATTCTATCT
ATAGATTTATATATGTATACATTCTGTACAGTAGTTCCATCAAAATATGTAATAATTCACACCAATTTTATTAAATGTATTTGCTTTTTC

>In-frame_ENST00000266534_ENST00000354981_TCGA-CQ-7072_TMEM117_chr12_44537427_+_KIF16B_chr20_16293063_length(amino acids)=250AA_start in transcript=127_stop in transcript=879
MGKDFRYYFQHPWSRMIVAYLVIFFNFLIFAEDPVSHSQTEANVIVVGNCFSFVTNKYPRGVGWRILKVLLWLLAILTGLIAGKFLFHQR
LFGQLLRLKMFREDHGSWMTMFFSTILFLFIFSHIYNTILLMDGNMGAYIITDYMGIRNESFMKLAAVGTWMGDFVTAWMLAALEFPPKK

--------------------------------------------------------------
>In-frame_ENST00000266534_ENST00000378003_TCGA-CQ-7072_TMEM117_chr12_44537427_+_KIF16B_chr20_16293063_length(transcript)=2028nt_BP=637nt
GTCTCGCCGCGCTTCCCAGCGAGGCCGCCGGCGCGCCGAGGGCTGTGCTCGACCGCGAATCCCGTGTGCAGTCGCCCCGCGCCCCGCGCG
ACCCTTCGGGTAAACTACGAACTGGGAGTTCTGAAGAATGGGTAAAGACTTTCGTTACTATTTCCAGCATCCCTGGTCTCGCATGATTGT
GGCTTACTTGGTGATCTTCTTTAACTTCTTAATATTTGCGGAGGACCCAGTTTCTCATAGCCAAACAGAAGCCAATGTTATTGTTGTTGG
AAACTGTTTTTCATTTGTTACAAATAAATACCCTAGAGGAGTTGGCTGGAGGATTTTGAAGGTGCTTCTATGGCTACTTGCCATTCTCAC
AGGACTAATAGCTGGCAAATTTCTGTTCCATCAGCGTTTGTTTGGTCAGTTGCTCCGATTAAAAATGTTTCGAGAAGATCATGGGTCGTG
GATGACAATGTTCTTCAGCACAATTCTCTTTCTCTTCATATTTTCTCACATATACAACACGATTCTTCTAATGGATGGGAACATGGGAGC
ATATATCATTACAGACTATATGGGCATCCGAAATGAAAGTTTCATGAAATTAGCTGCAGTAGGGACCTGGATGGGGGACTTTGTCACAGC
TTGGATGCTTGCTGCCCTTGAATTTCCTCCAAAGAAACTATTTGGAAATAAGGATGAACGTGTGATTGCTGAGAGACGAAGTCACTTAGA
GAAATACCTCAGGGACTTTTTCAGCGTGATGCTCCAGTCCGCAACATCTCCCCTCCACATCAACAAAGTGGGACTGACTCTCTCGAAACA
TACCATTTGTGAGTTTTCACCATTCTTCAAGAAAGGAGTCTTTGACTACAGCAGCCACGGGACGGGGTAGAGCCAGGGGTGATGGAGGAA
CCACCACAGCAGTGCCTTCTCGTCGAAGCGGGCTCCGATGCAGGGCAGCTCCCCCATGCGAGGATCCGGGTCTGCCTCCTCCTGCTGAAG
ACAGACATGCAGCAGCGGGCCCGGGCCACCTCACGTTTCCATACCTAGTGCCTGAGTTTGGGGATGGGATGCTCTGCCTGCTGATGTGGC
CCTGACAGGCAGCCGTTACCGTTCCATTGCGGTTGAACGTGGCCTTTTCCCACAGTGCTTCCTTCTCACTGCGCAGCAAAGTTCGTCCCC
TGTGGCAAGATAGATGTGGTTGGGCCATCGTGGGTTCCCTGAGCCCAGCCAGCCTGGGACCTCCCAAAGTGGGTGGCTTACCAGACCACC
CTTAAATGACTTTCATCTGGTTTCCTCTTTCACCAAAATATACTCGTATTTTTTATATTTCTTCCATGTGGCTGGCTATATTCCAAGAAA
AGCATTTTAAATTATTTCATTGTATTTTTTTCTTTTTTTCCCTCATTTGAATCAGAACTTTTATATAAAACCCAAACACTGATGTTTACA
CAGAATTTCATATTCTGCAAAAGGGATTTTTTGATCCAATCATGACTGTAGTCTTCCATGCTTGACAAATTGGATGTAGACAACATTACT
TAAAACTTCTATAAATCCCTACAATTAGGATATTTATTTAACCTTGAATATTCAAGAACATTCTCCCAAATCTAAATGGCTACTGTGCAT
TCTTGAGCTTTTTCTGCTAAGCACAAAATGAACGCAAAGCTAAATGCATATTTTTAAGTATTATTCACATTTTTTGTTACAGAATCTATT
GGATCTTTGGCTGGAAAACTAGAATTTATAGCAGTTTATTAATGATACCTTAAATTACTCAGGACTTAATGTAGCATTGCACTTCTGTGT
ACAGTAAAACTGCTTTGTTTTACTAAAGAGAAAAATGTGAGTGGAAAAAATATGTATGTGGTATATACTCAAATGTATATAATTCTATCT
ATAGATTTATATATGTATACATTCTGTACAGTAGTTCCATCAAAATATGTAATAATTCACACCAATTTTATTAAATGTATTTGCTTTTTC

>In-frame_ENST00000266534_ENST00000378003_TCGA-CQ-7072_TMEM117_chr12_44537427_+_KIF16B_chr20_16293063_length(amino acids)=250AA_start in transcript=127_stop in transcript=879
MGKDFRYYFQHPWSRMIVAYLVIFFNFLIFAEDPVSHSQTEANVIVVGNCFSFVTNKYPRGVGWRILKVLLWLLAILTGLIAGKFLFHQR
LFGQLLRLKMFREDHGSWMTMFFSTILFLFIFSHIYNTILLMDGNMGAYIITDYMGIRNESFMKLAAVGTWMGDFVTAWMLAALEFPPKK

--------------------------------------------------------------
>In-frame_ENST00000266534_ENST00000355755_TCGA-CQ-7072_TMEM117_chr12_44537427_+_KIF16B_chr20_16293063_length(transcript)=2028nt_BP=637nt
GTCTCGCCGCGCTTCCCAGCGAGGCCGCCGGCGCGCCGAGGGCTGTGCTCGACCGCGAATCCCGTGTGCAGTCGCCCCGCGCCCCGCGCG
ACCCTTCGGGTAAACTACGAACTGGGAGTTCTGAAGAATGGGTAAAGACTTTCGTTACTATTTCCAGCATCCCTGGTCTCGCATGATTGT
GGCTTACTTGGTGATCTTCTTTAACTTCTTAATATTTGCGGAGGACCCAGTTTCTCATAGCCAAACAGAAGCCAATGTTATTGTTGTTGG
AAACTGTTTTTCATTTGTTACAAATAAATACCCTAGAGGAGTTGGCTGGAGGATTTTGAAGGTGCTTCTATGGCTACTTGCCATTCTCAC
AGGACTAATAGCTGGCAAATTTCTGTTCCATCAGCGTTTGTTTGGTCAGTTGCTCCGATTAAAAATGTTTCGAGAAGATCATGGGTCGTG
GATGACAATGTTCTTCAGCACAATTCTCTTTCTCTTCATATTTTCTCACATATACAACACGATTCTTCTAATGGATGGGAACATGGGAGC
ATATATCATTACAGACTATATGGGCATCCGAAATGAAAGTTTCATGAAATTAGCTGCAGTAGGGACCTGGATGGGGGACTTTGTCACAGC
TTGGATGCTTGCTGCCCTTGAATTTCCTCCAAAGAAACTATTTGGAAATAAGGATGAACGTGTGATTGCTGAGAGACGAAGTCACTTAGA
GAAATACCTCAGGGACTTTTTCAGCGTGATGCTCCAGTCCGCAACATCTCCCCTCCACATCAACAAAGTGGGACTGACTCTCTCGAAACA
TACCATTTGTGAGTTTTCACCATTCTTCAAGAAAGGAGTCTTTGACTACAGCAGCCACGGGACGGGGTAGAGCCAGGGGTGATGGAGGAA
CCACCACAGCAGTGCCTTCTCGTCGAAGCGGGCTCCGATGCAGGGCAGCTCCCCCATGCGAGGATCCGGGTCTGCCTCCTCCTGCTGAAG
ACAGACATGCAGCAGCGGGCCCGGGCCACCTCACGTTTCCATACCTAGTGCCTGAGTTTGGGGATGGGATGCTCTGCCTGCTGATGTGGC
CCTGACAGGCAGCCGTTACCGTTCCATTGCGGTTGAACGTGGCCTTTTCCCACAGTGCTTCCTTCTCACTGCGCAGCAAAGTTCGTCCCC
TGTGGCAAGATAGATGTGGTTGGGCCATCGTGGGTTCCCTGAGCCCAGCCAGCCTGGGACCTCCCAAAGTGGGTGGCTTACCAGACCACC
CTTAAATGACTTTCATCTGGTTTCCTCTTTCACCAAAATATACTCGTATTTTTTATATTTCTTCCATGTGGCTGGCTATATTCCAAGAAA
AGCATTTTAAATTATTTCATTGTATTTTTTTCTTTTTTTCCCTCATTTGAATCAGAACTTTTATATAAAACCCAAACACTGATGTTTACA
CAGAATTTCATATTCTGCAAAAGGGATTTTTTGATCCAATCATGACTGTAGTCTTCCATGCTTGACAAATTGGATGTAGACAACATTACT
TAAAACTTCTATAAATCCCTACAATTAGGATATTTATTTAACCTTGAATATTCAAGAACATTCTCCCAAATCTAAATGGCTACTGTGCAT
TCTTGAGCTTTTTCTGCTAAGCACAAAATGAACGCAAAGCTAAATGCATATTTTTAAGTATTATTCACATTTTTTGTTACAGAATCTATT
GGATCTTTGGCTGGAAAACTAGAATTTATAGCAGTTTATTAATGATACCTTAAATTACTCAGGACTTAATGTAGCATTGCACTTCTGTGT
ACAGTAAAACTGCTTTGTTTTACTAAAGAGAAAAATGTGAGTGGAAAAAATATGTATGTGGTATATACTCAAATGTATATAATTCTATCT
ATAGATTTATATATGTATACATTCTGTACAGTAGTTCCATCAAAATATGTAATAATTCACACCAATTTTATTAAATGTATTTGCTTTTTC

>In-frame_ENST00000266534_ENST00000355755_TCGA-CQ-7072_TMEM117_chr12_44537427_+_KIF16B_chr20_16293063_length(amino acids)=250AA_start in transcript=127_stop in transcript=879
MGKDFRYYFQHPWSRMIVAYLVIFFNFLIFAEDPVSHSQTEANVIVVGNCFSFVTNKYPRGVGWRILKVLLWLLAILTGLIAGKFLFHQR
LFGQLLRLKMFREDHGSWMTMFFSTILFLFIFSHIYNTILLMDGNMGAYIITDYMGIRNESFMKLAAVGTWMGDFVTAWMLAALEFPPKK

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Fusion Gene PPI Analysis for TMEM117-KIF16B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMEM117-KIF16B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMEM117-KIF16B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMEM117C0008370Cholestasis1CTD_human
HgeneTMEM117C0019193Hepatitis, Toxic1CTD_human
HgeneTMEM117C0860207Drug-Induced Liver Disease1CTD_human
HgeneTMEM117C1262760Hepatitis, Drug-Induced1CTD_human
HgeneTMEM117C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneTMEM117C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneTMEM117C4279912Chemically-Induced Liver Toxicity1CTD_human