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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BAZ1A-RNF115 (FusionGDB2 ID:9093)

Fusion Gene Summary for BAZ1A-RNF115

check button Fusion gene summary
Fusion gene informationFusion gene name: BAZ1A-RNF115
Fusion gene ID: 9093
HgeneTgene
Gene symbol

BAZ1A

RNF115

Gene ID

11177

27246

Gene namebromodomain adjacent to zinc finger domain 1Aring finger protein 115
SynonymsACF1|WALp1|WCRF180|hACF1BCA2|ZNF364
Cytomap

14q13.1-q13.2

1q21.1

Type of geneprotein-codingprotein-coding
Descriptionbromodomain adjacent to zinc finger domain protein 1AATP-dependent chromatin remodeling proteinATP-utilizing chromatin assembly and remodeling factor 1CHRAC subunit ACF1hWALp1williams syndrome transcription factor-related chromatin-remodeling factor E3 ubiquitin-protein ligase RNF115RING-type E3 ubiquitin transferase RNF115rabring 7zinc finger protein 364
Modification date2020031320200313
UniProtAcc

Q9NRL2

.
Ensembl transtripts involved in fusion geneENST00000358716, ENST00000382422, 
ENST00000360310, ENST00000553853, 
ENST00000369291, 
Fusion gene scores* DoF score12 X 9 X 5=54011 X 8 X 6=528
# samples 1210
** MAII scorelog2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/528*10)=-2.40053792958373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BAZ1A [Title/Abstract] AND RNF115 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBAZ1A(35343698)-RNF115(145646115), # samples:3
Anticipated loss of major functional domain due to fusion event.BAZ1A-RNF115 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
BAZ1A-RNF115 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
BAZ1A-RNF115 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
BAZ1A-RNF115 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
BAZ1A-RNF115 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBAZ1A

GO:0006261

DNA-dependent DNA replication

12434153

TgeneRNF115

GO:0051865

protein autoubiquitination

16288031


check buttonFusion gene breakpoints across BAZ1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RNF115 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-63-6202-01ABAZ1Achr14

35343698

-RNF115chr1

145646115

-
ChimerDB4LUSCTCGA-63-6202BAZ1Achr14

35343698

-RNF115chr1

145646115

+
ChimerDB4LUSCTCGA-63-6202-01ABAZ1Achr14

35343698

-RNF115chr1

145646115

+


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Fusion Gene ORF analysis for BAZ1A-RNF115

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000358716ENST00000369291BAZ1Achr14

35343698

-RNF115chr1

145646115

-
In-frameENST00000382422ENST00000369291BAZ1Achr14

35343698

-RNF115chr1

145646115

-
Frame-shiftENST00000360310ENST00000369291BAZ1Achr14

35343698

-RNF115chr1

145646115

-
intron-3CDSENST00000553853ENST00000369291BAZ1Achr14

35343698

-RNF115chr1

145646115

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000382422BAZ1Achr1435343698-ENST00000369291RNF115chr1145646115-92524415701253227

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000382422ENST00000369291BAZ1Achr1435343698-RNF115chr1145646115-0.0197081880.9802918

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Fusion Genomic Features for BAZ1A-RNF115


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BAZ1Achr1435343697-RNF115chr1145646114-7.37E-070.9999993
BAZ1Achr1435343697-RNF115chr1145646114+7.37E-070.9999993
BAZ1Achr1435343697-RNF115chr1145646114+7.37E-070.9999993
BAZ1Achr1435343697-RNF115chr1145646114-7.37E-070.9999993
BAZ1Achr1435343697-RNF115chr1145646114+7.37E-070.9999993
BAZ1Achr1435343697-RNF115chr1145646114+7.37E-070.9999993

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BAZ1A-RNF115


check button Go to

FGviewer for the breakpoints of chr14:35343698-chr1:145646115

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BAZ1A

Q9NRL2

.
FUNCTION: Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression.; FUNCTION: Component of the histone-fold protein complex CHRAC complex which facilitates nucleosome sliding by the ACF complex and enhances ACF-mediated chromatin assembly. The C-terminal regions of both CHRAC1 and POLE1 are required for these functions.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRNF115chr14:35343698chr1:145646115ENST0000036929109228_26934.0305.0Zinc fingerRING-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000358716-226306_39737.6666666666666641525.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000358716-226634_70937.6666666666666641525.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000360310-227306_39737.6666666666666641557.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000360310-227634_70937.6666666666666641557.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000382422-126306_39737.6666666666666641557.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000382422-126634_70937.6666666666666641557.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000358716-2261239_125737.6666666666666641525.0Compositional biasNote=Glu-rich
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000358716-226487_49137.6666666666666641525.0Compositional biasNote=Poly-Glu
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000360310-2271239_125737.6666666666666641557.0Compositional biasNote=Glu-rich
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000360310-227487_49137.6666666666666641557.0Compositional biasNote=Poly-Glu
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000382422-1261239_125737.6666666666666641557.0Compositional biasNote=Glu-rich
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000382422-126487_49137.6666666666666641557.0Compositional biasNote=Poly-Glu
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000358716-2261446_151637.6666666666666641525.0DomainBromo
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000358716-22622_12837.6666666666666641525.0DomainWAC
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000358716-226422_48737.6666666666666641525.0DomainDDT
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000360310-2271446_151637.6666666666666641557.0DomainBromo
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000360310-22722_12837.6666666666666641557.0DomainWAC
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000360310-227422_48737.6666666666666641557.0DomainDDT
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000382422-1261446_151637.6666666666666641557.0DomainBromo
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000382422-12622_12837.6666666666666641557.0DomainWAC
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000382422-126422_48737.6666666666666641557.0DomainDDT
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000358716-2261_12837.6666666666666641525.0RegionNote=Required for association with the CHRAC1/POLE3 complex
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000360310-2271_12837.6666666666666641557.0RegionNote=Required for association with the CHRAC1/POLE3 complex
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000382422-1261_12837.6666666666666641557.0RegionNote=Required for association with the CHRAC1/POLE3 complex
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000358716-2261148_119837.6666666666666641525.0Zinc fingerPHD-type
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000360310-2271148_119837.6666666666666641557.0Zinc fingerPHD-type
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000382422-1261148_119837.6666666666666641557.0Zinc fingerPHD-type


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Fusion Gene Sequence for BAZ1A-RNF115


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000382422_ENST00000369291_TCGA-63-6202-01A_BAZ1A_chr14_35343698_-_RNF115_chr1_145646115_length(transcript)=9252nt_BP=441nt
CCCGCACTGCCCCCCGCGGCGGGGCGTCCTGCCCCATTGTGAGGCGGCGGCAGGACGAGAGGAGGTAGGGCGCGCTCGGGGGGCAGGGGC
GGCGGCGGCTCCGCTCGCTCGACACCCGGGCAGCGGCAGGAACGAACTCGGCTCCGGTAGCGGCCGCGGCGCGTCAGTCACACAAAAGGC
AGCCGAGCTTCTCCCAGCGCGCGGACCGGCCCACGCTGCCGCCGAGGGCTCCCCACCTTACCGGCTTTCCTTTCCCTCCAATTTTGATAG
GGAAGCGGGGCCGGCGCGGGCGGCCGAGGGTCCAGGCGAGCCCGCGGGCGGACGGGAGATGCCGCTGCTACACCGAAAGCCGTTTGTGAG
ACAGAAGCCGCCCGCGGACCTGCGGCCCGACGAGGAAGTTTTCTACTGTAAAGTCACCAACGAGATCTTCCGCCACTACGAGAATATATA
TGTCCCAGATGTGAATCAGGCTTTATTGAAGAAGTGACAGATGATTCCAGTTTTTTAGGTGGTGGCGGCAGTCGGATAGACAATACCACA
ACAACACATTTTGCAGAGCTTTGGGGCCATTTGGATCACACGATGTTTTTTCAAGATTTTAGACCCTTTCTAAGTAGCAGTCCACTGGAC
CAAGATAATAGAGCCAATGAAAGGGGTCACCAGACTCACACTGACTTCTGGGGAGCAAGACCTCCACGGTTGCCATTGGGTCGGAGATAC
AGATCTCGAGGAAGTTCTCGTCCTGACAGATCTCCAGCTATTGAAGGAATACTACAACACATCTTTGCAGGATTCTTTGCAAATTCTGCC
ATTCCTGGATCTCCACACCCTTTTTCCTGGAGCGGGATGCTGCACTCCAACCCTGGGGACTATGCCTGGGGTCAGACAGGGCTTGATGCC
ATTGTAACCCAGCTTTTAGGACAACTGGAAAACACAGGCCCTCCCCCAGCTGACAAGGAAAAGATCACATCTCTTCCAACAGTGACAGTA
ACTCAGGAACAAGTTGATATGGGTTTAGAGTGTCCAGTATGCAAAGAAGATTACACAGTTGAAGAGGAAGTCCGGCAGTTACCTTGCAAT
CACTTCTTTCACAGCAGTTGTATTGTGCCGTGGCTAGAACTGCATGACACATGTCCTGTATGTAGGAAGAGCTTAAATGGTGAGGACTCT
ACTCGGCAAAGCCAGAGCACTGAGGCCTCTGCAAGCAACAGATTTAGCAATGACAGTCAGCTACATGACCGATGGACTTTCTGAAGCTAA
AGACCACACCTGAATCAGGGCTGTGGTAATCATCTTACCATAGCTGTAAATTGTATCAAAACAAAAAATTAGTAGATGGATTTAGGAATA
TGTAAGAAACTCAACACATAATATAAATGCAATGAATGTTTTTCTTCTTTAAATTTAAAGTTAGTATCTACAGATGGAATTGTATCTACA
ACCAAATGCCTCTTATCCCTGAATTCAGAGTGATAATTTTATAAGTGTGAAACTTAATTATGTAGGGCTCCCCCCGTCTGAATAGAATTA
ATTCCTTAAAGTCTAGTTAGGGTCCTGCTGTCTGTCATGTTGCCTTGTAACGGATGTTTCCACCTCCTTCTCCAACCTCTACCCCACCAT
TAGTGTATTTTACTATAAAAACAGTGGAACCACAGCCCTAAAGTCCTGCTGATATAAAGTCCTTTTGTCTTAATTGTATTTAAAAAAAAA
AAAAAACTACTCTTGATCACATTAGCTATGAGGCGAGGTCAAATTCAGGTATCTAAGACTAATGATTTTGTTTTGTCTTGATCCCCAGAG
AGCAAATCAAAGAAAAATTACAGCAAGAAGAGAAAAGTGGTTTATCATTGTGTGCTTTGGTTTTCTTATTTTAATTTTTTTTGTTTTTTT
TTTTTGAGATGGAGTCTCGCTCTGTCGCCTAGGCTGGAGTGCAGTGGCACGATCTTGGCTCATTGCAAACTCTGCCTCCTGAGTTCAAGC
GATTCTCCTACCTCAGCCTCCAGAGTAGCTGGGACCACAGGCATTTGTTACCATGCCCAGCTAATTTTTTGTATATTTAGTAGAGATGGG
GTTTCACCGTGTTAGCCAGGATGGTCTCAATCTCCTGACCTTGTGCTCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGA
GCCACTGCGCCTGGCCTCTTATTTTAATTTTTAAAGACTACTTCAGTTGATGCAGTTTCCCAAGAAACCTACATAACATATATTGGGAGC
CTTATGTTGATAGGAATCTGATTCCCATTCCTTTTTGGGAATGAGTTGGGCAGCATACAGGCACAGAAAGACAGATGTTTGAGACCTTTG
CTTCTGAGATTTTAAAAAATGATTACCGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCAC
AAGGTCAAGAGATCAAGACCAGCCTGGCCAACAAGGTAAAACCTTGTCTCTACTAAAAATATAAAATTAGCTGGGCCTGGTGGTGCATGC
CTGTAATCCCAGCTACTCATGAGGCTGAGGTGGGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCGGTGAGCCGGATCATACCAATGCA
CTCCAGTCTGGGCAACAAGAGCGAAACTCCATCTCAAAAAAAAAAAAAAAATCCCCAACTCACTGCTTTTTTTGTTTGTTTCTGTCGCCT
AGGCTGGAGTGCAGTGGCACGATCTCAGCTCACCACAGCCTCGACCTCCCAGGCTCAAGTGATCCTCCCACCTCAGCCTACCAAGTGGCT
GGGACTACAGGCGTGTGCCACCATGCCTGGGTAATTTTTGTATTTTTGTAGAGATAGGGTTTTGCCGTGTTGCCCAGGCTGGTCTCAAAC
TCCTGGGCTCAAGTGATCTGCCTGCCTCAACCTCTCAAAGTGCTCAACTCATTGTTTACTGTCTTTTTTCCTAGTAATCTTAAAATAATT
TGCCTCACAGAAATAGAGACAGTAAGTGTCTGCAGCCAGTTCACTGTTTTTGGTAATTCATTGGTCTTCAGGAGTTAAGATTTTACATTG
TCACATTTTAATTTTTAAGCCTATTTTTCATCTCTGAAACTTTCCTTTTCTCCTTGGTTCTGGCTATACTTGGACTCAAACTGATCAGTG
TGATCATGTCCAAAACAGCTTGGCCTGGAAGAGGTAGGCCTTATTTTTTCAGCCTAGTAGTGTCCCATGCACATGCTCTTTGTAGCATTC
AAGTGTTTAACATTGGATAAATTAAGAAGGTCAAGAATGTTGTTGAAACTTCAAGGTCTCAAAAGGAAATGATGGGGACATAGAACAACT
GTTGGTGTACCAAAAAAAGGTACAGAGGGGCACCATTTGTATTGTCACACAACAATGATCAGAATGATCAGTTTAGAATGATCAGAACAA
AAACACCACTCTTTAATGGGTCTTTTTCTTGGCTAGAAGTCTTTCCTCAGTTTTTGTTGACTATCATACGCTGATTTGTGGGTGACGGAA
GGGGGCTAGAGATAACGTTTCTCTGTACTTTGGTAAAGGATGAAGGAGTCAGAGAGGGAACAGAAAAAGTGAGAGAGTGGCCTGCTGAAA
TAATAGCCTGCCTCTAAAAGTTGTGACCAGAAAGTATGATTCATTTGGGCCCAGAGGGAATAAAATATGTTTTTTCATATACCTCCCATA
TTACACCTCTGTAGTGATTGTTTATTTGGGGAATGAGATCTACTTACTGTGCGTTGCCCCTGAAATGTAGCTTGAGAATACACACTGGTT
TTGAATTGGGGAGGAGGATGGAAGGAAATTAGAGGTGTATTATGAATATTTGGCCACTACTTAGATGGAGGAAGGCTATGTTGAACTTGG
GACACATTGCAGTTTTCAAGTACACAATATCAGTTGTCTCAGAAAAATCATGACAGCCTGGACATATTTGCTTGTCAGTGTCTGGAGATG
CCAGGACAGGCAGTTGTAGTTTTACGTACAGATAGAGAACCAATGCCTAGAGAACTAGAAAGGATCTGAGTAGCTTTAAAAAGGGTGGAA
ACAAAGTACTGGATAGGGGTCTGCCTTTTTATACACAGTATAGCAAACAGCATCAGACAAAGTTACATGAAGTTTTCTTCACTTTTTTTG
CTCTGATGGATAGAGGATGTGAGACTCATTTTACTGTTTCCCAGACCTGTCCCACTTAATGGATCTGTTGTGTTTCTTCTTATAATGGCA
GGCACCTCAGATGTCCAGGTTAATTTATGTTGAGGAGTTAGGATTCTTCAGGGATTTATTATTATTATTATTATTATTTATTTATTTATT
TATTTATTTATTTATTTTTTGAGATGGAGGCTTGCTCTGTCGCCTAGGCTGGAGTGCAGTGGCGCAATCTCAGCTCACTGCAACCTCCAC
CTCCTGGGTTCCAGCGATTCTTCTGCCTTAGCCTCCCAAGCAGCTGGGATTACAGGCACCTGCCACCATGCCCAGCTAATTTTTTATATG
TTTAGTAGAGACAAGGTTTTACCTTGTTGGCCAGGCTGGTCTTGAACTCTAGACCTCAGGTGATCTGCCAGTCGTGGCCTCCCAAAGTGC
TGGGATTACAGACGGGAGCCACCATGCCCAGCCTGAGATTTATTATAAGGAATTGGTTCACACAATAATGGAGTTTGAGAAATCCCAAGA
TCTGCAGTGGGCCAGCTAGAGATCCAGGAGAGCTGATGGTGTAGTTCCAGTCTGAAGGCCAGCTTGGATACCCTAGAAGAGCTGATGTTT
CTGTTCCAGTTCAGAGGCAGGAAAAGACTGAGGTCTTAGTTCAAGCAGTCAGGCAGGAGGACTTCTCCCTTACTTGTTCTATTCAGACCT
TCAACTGATTGGATGAGGGCCACTTACATTAGGGAGGGCCATGTGCTGTATTCAGTCTACTGACTGAAATGTTAGTCTCTTCCAAAAACA
CCCTCACAGACACACCCAGAATACTGTATGACCAAATATCTGGGCATCATGTGGCCTAGTCAAGTTGACACATAAGATTAACCATCACAA
TGAGGAAAAACAGAAATGATACATGTATACAGAGTGCTCCTCATCCCAATTAAGTTTCACCAAGTTAATAATGTGTCTCTATGAGAAGTG
GTTCACCATGTTGGTCAGGCTGTTTTCAAACTCCTGACCTCAGGTGACCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGA
GCTAGCACTCCCAGCCGACAGGTGCTTCTTAAATGTTTTCTTTGAGCAGGAATTGGTCCAGGAATTGGTTCTCAAGTTAGAAGGAAAATT
TGAGGGGAAGAACTTGTTTTTTCTCCAATCAGTCTCTGATTAAATAGTTATTAGGAAAAACTCCTTGCTTATGTCTTTGTATTGCACATT
TTTATATATGTATATATGTGTAAATAGAGATATTTATATATTCACAGACAAACACGTGTATGCACATTTCACAATGGAGGAAGAAGGGAT
ATGGTGTGCACTGAGGTAAAGTGAGCAGGGATACAGAAGAGAGCTGGAGCCTCACAGTCTGATTCTCTCATTGTACATAACCTTTAGGGT
CTTTGTTTCCCTGAGTTCTCTGGTATGGGGCACTGTTGGCTTGGGCTGGTACCCTGTTATTCTCTGTGATGAAGGGATTCACTGGAGGTA
AAAACGTAATCATTTCCAAAGGTTGAGAATAAATGACTTTGAGGAAAGGGTGTTCATTATCCGTTGCTTCTATATTATAATCAGTTGAAC
TACAATACGGTTATCTATTGATTTTTTTTAATTTTTCTGACAAATTATTGACACCAAATTGAATAATTCATGACCTGCATGCTTCAGCTT
CTTTCTCCCTGGTTTCCAGGTGCTATTCCCTCAAGAAATGCAAATTAAATATGTCGGTCTTAATAAATCAGGAGGGAAGCATAGTCTGTG
TCTGTTTTAAATGACAACAACAACAAAACAGCTTTGGGGTTTAAGAAGTGGAAGACACATTTTTATTTTTTTGAGACACAATCTCACTCT
TTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGGTCACTGCAACCTCCCGCTCCTGGGTTCAAGCGATTCTCTTGCCTCAGCCTCCCA
AGTAGCTGGGATTACAGGCACGTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTTGCCATGTTGCCCAGGCTGG
TCTCGAACTCCTGATGTCAAGTGATCACCGACCTCAGCATCCCAAAGTGCTGGGATTACAGGCATTAGCCACCACGCCCAGGTGAGAAGA
CAGATTTTAAGAGAAGGAGCAGGGCTGGTATCTGAATAGGTATTTGGATGTTAGGGGAAAACCCTTTTTGGCCTCTGTGGTAGAGCGATC
GGAAGGTAAAAGTGCTGTTTACAAGAATAATCCATTGGAGATCTGGGGATTGGGGACGACTTATAGGATAGAGTCCTCTTGTTGAGAATT
TCCCGAATGAATCTCATGTAGGTTCTGTCACAGTAAGATGGAGGAAAACTTTGATGGGGTAAGTATCACAAGTGGCTGTCCTATAGGGGG
AAATCCTAGCCTGCAGTAATGTCAGTGTCTCAGTATTCAGCCAGCGAGCCACTGAGCTGCTCCAGGGGTTTAAAATAGAATGCATAGAAT
ACAATGTATACAGCTGGTGATGCTTTCCAGGATCAAAATAGAGCCCTTGTCTGATCCCATTGACATTGTAAGGTTTCGATCTCTCATACC
TGCCACAGACAAGTACATTGTAGGCATTCAACTTTTAAGGTTTTATACATGCAAACTTTATGTTTTCCTGCCACACTACACTTGGTGTCC
ACAGAAGTGTAGTTTGTATGTTGCCTCTTCTTCCTCTTTCAACCAGAACACTTAGATCTGTGATCATAGGATGTAAGCCTGTGATTCTTT
ACTTTTTCTAATAAGAAATACAATTTTCAAGATCCAAAAATTATTAGATTCTTGGCTGGGCATTGTGGCTCATGCCTGTAATCTCAGCAT
TTTGGAAGGCTGAGGCAGGCAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGGCAGCACAATAAAACACCATGTCTACTAAAAATA
CAAAAATTAGCCAGGTGTGGTGGCATGCACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGAGGGAGAATCGTTTGAACCAAGGAGGCAGA
GGTTGTAGTGAGCCAAGATTGTGCCACTGCACTCCAGGGCAACAGAGAGAGACCCTGTCTCAAAACAAAAACCCCCAAATTATTAGATTC
CCTTCCAACAACTTGATAGCCATATTATTAGTATTTTTGATTAAAGAATACATAACAAAAAGCTGCTATGATTTCAGTAATGCTTTTAAG
TTAATTTATTAGTCACACCAGAATCTACATCCAATTGAAATATATACAAATATTTGAAAGATATTTATTCAGGCTGAAGATTATGGTATA
TAGATTCCTTCTGATAACCTCATGGCCTCACAGGTTCAAAACCCGTGTTTGTGAATCACTCATACAGATTGGGGCTAAGATGCGTGTCCA
GAAAACCACCTATTATGCATGAAAATTTGTAGGCTTATTTGAAGGCAATTGTATCAACACATTTTGAAAGCCAAGACACAAGTATTTTAA
GTTTCTGTTTAACCAAGTCTCGAGATAAGCAGAGTAAATAAACTCTTTAGAAGCAAGACTCAGTTGGTATGTACAAAGTGGGATTGCTTT
GTATATATTCCGCTTAGTTTGAGTCAGAGCTAGTAATCTGATGCTCTTAAATGTCTTCATAAACTTGGGCAGTGATGTTTCCTTTCTGTG
ATTATGTGTCACAGATTTTTATATGTGGACTATAATTAGTATAGTACAATGGCTGAAACTTTTCCTATAGTTGGATATATCTTCTGAGAC
TTCCAGTGATTGTATAATGTTGAGTAGCTCCAGAAGATTATTTGAATAGTAAAAACAAAAGACATCTCTACCTATGTGAGTTTATTATTT
AGTTAGAAACACAGAACTAACTATTTAAAACAGGTAGAGAAAGATTAAGATGAATGTGATGTAGTGGAGAAAGCTTTGGAGACTTTGGAG
TCAGAACTCAAATGGCTCTAGGTCCCAAATCCAGACTCTCATTTTGATTCTCAGAACAATTCTGTGGAAAGAGAAGATACAATAGGCAAT
ATCCCTTTTTACAGATAGGTAAACAGAAATAGCATCTCAAAACCTCATTTGCACTGGGTGAGGTGGCTCACGCCTGTAATCCCAGCACTT
TGGGAGGCTGAGGCGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACCAAAAACACA
AAAATTAGCCAGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTTGGGAGACTGAGGCAGGAGAATTGCTTGAACCCGGGAGGTGGAGG
TTGCAGTGAGCTGAGATCATGCCACTGCACTCCAGCCTGGGCAACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAATTCATTTGCC
CAATGACAAATAGCTGGTATGTTGCAGAGCCAGAATTTGAATCCAGGTCTTTTTGCCTCCATGGCTAGTCCTTTTATCTCCATGGGATAC
AGTCTAAAATCCTTAGTTTGAGGTTCAAGACTATCACTAATAAGAGTCTTACTCATCTACTTCAGCCATATCTCTTTCCGTTCCCACAAA
CCTTAGCTCCCACATTTGGCAGGTCCTTGCCAAGGAGCACAGGTAAAGTGTCTCTTTCCTTTTAATGGCTCACCATGGAGCTGTAGCTAA
ATTTCTGTGCTCTTACCCCTTTATTCATGTAGTTCCTCCTATCAGGAATATCCTGCCCACTCTCTGCTTAACTATGACAAGAGGTCATCT
GTCCAAAGAGAAAGAAGAGAGTTTGTGGATTTAGGAGAAAAGAAAATACTCCAAATACTGCTATGGGCATTTATTTAAAAAGAGAAATGA
CCAAAGAGGTTAACAAGTATTTAGATGAAGCTGGGCAGTTGTAGTCTGTGGTGCTCTTGGTCTGCACAAATCTTCCTCTTCCTCCAGCAG
TGCTGTATGGATGTTGTTGAATGTTGAGGTCTGTCTGCATTTTCTCATTTTCATGCCAAGTCAATCACTGGATCTGGCTGTCTTCCTTTC

>In-frame_ENST00000382422_ENST00000369291_TCGA-63-6202-01A_BAZ1A_chr14_35343698_-_RNF115_chr1_145646115_length(amino acids)=227AA_start in transcript=570_stop in transcript=1253
MDHTMFFQDFRPFLSSSPLDQDNRANERGHQTHTDFWGARPPRLPLGRRYRSRGSSRPDRSPAIEGILQHIFAGFFANSAIPGSPHPFSW
SGMLHSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLECPVCKEDYTVEEEVRQLPCNHFFHSSCIVP

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Fusion Gene PPI Analysis for BAZ1A-RNF115


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000358716-226667_93337.6666666666666641525.0SMARCA5
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000360310-227667_93337.6666666666666641557.0SMARCA5
HgeneBAZ1Achr14:35343698chr1:145646115ENST00000382422-126667_93337.6666666666666641557.0SMARCA5


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BAZ1A-RNF115


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BAZ1A-RNF115


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRNF115C0006142Malignant neoplasm of breast1CTD_human
TgeneRNF115C0678222Breast Carcinoma1CTD_human
TgeneRNF115C1257931Mammary Neoplasms, Human1CTD_human
TgeneRNF115C1458155Mammary Neoplasms1CTD_human
TgeneRNF115C4704874Mammary Carcinoma, Human1CTD_human