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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:TMEM123-KIAA1377 (FusionGDB2 ID:90959) |
Fusion Gene Summary for TMEM123-KIAA1377 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM123-KIAA1377 | Fusion gene ID: 90959 | Hgene | Tgene | Gene symbol | TMEM123 | KIAA1377 | Gene ID | 114908 | 57562 |
| Gene name | transmembrane protein 123 | centrosomal protein 126 | |
| Synonyms | KCT3|PORIMIN|PORMIN | KIAA1377 | |
| Cytomap | 11q22.2 | 11q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | poriminKCT-3keratinocytes associated transmembrane protein 3pro-oncosis receptor inducing membrane injuryserine/threonine-rich receptor | centrosomal protein of 126 kDacentrosomal protein 126kDa | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000361236, ENST00000398136, ENST00000532161, ENST00000525577, | ENST00000263468, ENST00000537689, | |
| Fusion gene scores | * DoF score | 16 X 10 X 10=1600 | 4 X 3 X 4=48 |
| # samples | 27 | 4 | |
| ** MAII score | log2(27/1600*10)=-2.56704059272389 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMEM123 [Title/Abstract] AND KIAA1377 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | TMEM123(102272270)-KIAA1377(101814996), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TMEM123 | GO:0070267 | oncosis | 9600958|11481458 |
| Fusion gene breakpoints across TMEM123 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across KIAA1377 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BLCA | TCGA-GD-A3OS-01A | TMEM123 | chr11 | 102272270 | - | KIAA1377 | chr11 | 101814996 | + |
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Fusion Gene ORF analysis for TMEM123-KIAA1377 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000361236 | ENST00000263468 | TMEM123 | chr11 | 102272270 | - | KIAA1377 | chr11 | 101814996 | + |
| 5CDS-intron | ENST00000361236 | ENST00000537689 | TMEM123 | chr11 | 102272270 | - | KIAA1377 | chr11 | 101814996 | + |
| In-frame | ENST00000398136 | ENST00000263468 | TMEM123 | chr11 | 102272270 | - | KIAA1377 | chr11 | 101814996 | + |
| 5CDS-intron | ENST00000398136 | ENST00000537689 | TMEM123 | chr11 | 102272270 | - | KIAA1377 | chr11 | 101814996 | + |
| Frame-shift | ENST00000532161 | ENST00000263468 | TMEM123 | chr11 | 102272270 | - | KIAA1377 | chr11 | 101814996 | + |
| 5CDS-intron | ENST00000532161 | ENST00000537689 | TMEM123 | chr11 | 102272270 | - | KIAA1377 | chr11 | 101814996 | + |
| intron-3CDS | ENST00000525577 | ENST00000263468 | TMEM123 | chr11 | 102272270 | - | KIAA1377 | chr11 | 101814996 | + |
| intron-intron | ENST00000525577 | ENST00000537689 | TMEM123 | chr11 | 102272270 | - | KIAA1377 | chr11 | 101814996 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000361236 | TMEM123 | chr11 | 102272270 | - | ENST00000263468 | KIAA1377 | chr11 | 101814996 | + | 7282 | 761 | 24 | 3866 | 1280 |
| ENST00000398136 | TMEM123 | chr11 | 102272270 | - | ENST00000263468 | KIAA1377 | chr11 | 101814996 | + | 7544 | 1023 | 85 | 4128 | 1347 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000361236 | ENST00000263468 | TMEM123 | chr11 | 102272270 | - | KIAA1377 | chr11 | 101814996 | + | 0.000636411 | 0.9993636 |
| ENST00000398136 | ENST00000263468 | TMEM123 | chr11 | 102272270 | - | KIAA1377 | chr11 | 101814996 | + | 0.000848457 | 0.9991516 |
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Fusion Genomic Features for TMEM123-KIAA1377 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| TMEM123 | chr11 | 102272269 | - | KIAA1377 | chr11 | 101814995 | + | 0.011839043 | 0.98816097 |
| TMEM123 | chr11 | 102272269 | - | KIAA1377 | chr11 | 101814995 | + | 0.011839043 | 0.98816097 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for TMEM123-KIAA1377 |
| Go to FGviewer for the breakpoints of chr11:102272270-chr11:101814996 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TMEM123 | chr11:102272270 | chr11:101814996 | ENST00000361236 | - | 3 | 4 | 52_153 | 181.66666666666666 | 190.0 | Compositional bias | Note=Thr-rich |
| Hgene | TMEM123 | chr11:102272270 | chr11:101814996 | ENST00000398136 | - | 4 | 5 | 52_153 | 200.66666666666666 | 209.0 | Compositional bias | Note=Thr-rich |
| Hgene | TMEM123 | chr11:102272270 | chr11:101814996 | ENST00000361236 | - | 3 | 4 | 27_166 | 181.66666666666666 | 190.0 | Topological domain | Extracellular |
| Hgene | TMEM123 | chr11:102272270 | chr11:101814996 | ENST00000398136 | - | 4 | 5 | 27_166 | 200.66666666666666 | 209.0 | Topological domain | Extracellular |
| Hgene | TMEM123 | chr11:102272270 | chr11:101814996 | ENST00000398136 | - | 4 | 5 | 167_187 | 200.66666666666666 | 209.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TMEM123 | chr11:102272270 | chr11:101814996 | ENST00000361236 | - | 3 | 4 | 188_208 | 181.66666666666666 | 190.0 | Topological domain | Cytoplasmic |
| Hgene | TMEM123 | chr11:102272270 | chr11:101814996 | ENST00000398136 | - | 4 | 5 | 188_208 | 200.66666666666666 | 209.0 | Topological domain | Cytoplasmic |
| Hgene | TMEM123 | chr11:102272270 | chr11:101814996 | ENST00000361236 | - | 3 | 4 | 167_187 | 181.66666666666666 | 190.0 | Transmembrane | Helical |
| Tgene | KIAA1377 | chr11:102272270 | chr11:101814996 | ENST00000263468 | 1 | 11 | 49_121 | 82.66666666666667 | 1118.0 | Coiled coil | Ontology_term=ECO:0000255 |
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Fusion Gene Sequence for TMEM123-KIAA1377 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000361236_ENST00000263468_TCGA-GD-A3OS-01A_TMEM123_chr11_102272270_-_KIAA1377_chr11_101814996_length(transcript)=7282nt_BP=761nt CCCAGCCCGGCCCCGCCGCCCCGGCTGCGCACGCGACGCCCCCTCCAGGCCCCGCTCCTGCGCCCTATTTGGTCATTCGGGGGGCAAGCG GCGGGAGGGGAAACGTGCGCGGCCGAAGGGGAAGCGGAGCCGGCGCCGGCTGCGCAGAGGAGCCGCTCTCGCCGCCGCCACCTCGGCTGG GAGCCCACGAGGCTGCCGCATCCTGCCCTCGGAACAATGGGACTCGGCGCGCGAGGTGCTTGGGCCGCGCTGCTCCTGGGGACGCTGCAG GTGCTAGCGCTGCTGGGGGCCGCCCATGAAAGCGCAGCCATGGCGGAGACTCTCCAACATGTGCCTTCTGACCATACAAATGAAACTTCC AACAGTACTGTGAAACCACCAACTTCAGTTGCCTCAGACTCCAGTAATACAACGGTCACCACCATGAAACCTACAGCGGCATCTAATACA ACAACACCAGGGATGGTCTCAACAAATATGACTTCTACCACCTTAAAGTCTACACCCAAAACAACAAGTGTTTCACAGAACACATCTCAG ATATCAACATCCACAATGACCGTAACCCACAATAGTTCAGTGACATCTGCTGCTTCATCAGTAACAATCACAACAACTATGCATTCTGAA GCAAAGAAAGGATCAAAATTTGATACTGGGAGCTTTGTTGGTGGTATTGTATTAACGCTGGGAGTTTTATCTATTCTTTACATTGGATGC AAAATGTATTACTCAAGAAGAGGCATTCGGTATCGAACCATAGCTTTTGAGGAGAAACGAAAAGAACAGGAAGAAAAAGAACACCAAATT AGAGAACAAATACTTCAACAAAGAAAACAGAAGTTTGAAGAAGTTACTGAAAAATTCCAGCGTGCCCATGTTCCTCTTTCACAGCGGAGG AAAGCAGTTTCCCGAAAACCAGTTCCTCCATTAGAAGAGGCCCTCAAACAAATTCAGGAATCCAACTTAAAATCAGAAGTAAACCTTCCC TTTTCCCGTAGACCAACAATAAACTGGAGAGCTATAGATTCTGCCTTGCCTTCCGCATTATCAAAAAATGATCACAAGCATCAGAAACAA CTCTTATCCAAAATCAATTGTGAGAAAGAAATGAATGAAAACATGAGGGCAACCTTGGCTACTAGCAAAAATGTGTTCCAGCTTAAACTG GAGGAAACTCAGAAACTCCTCGAAGATCAACATCTAAGCAATTTGCAAAAATTTGGTGATGAAGTTAATCAGATAACCAATTCTGAAACC CTCTCAAGTATAGACAGTCTTGAGGCTACAGAGCATGAAGAAATATATTTAACACTTAATAAGGAGCATTCCACATCCATCCAGCGGAAT ACCATTTCCCTCAAACCAGCAAATATGCAATCAACTAATCTCAGCTGCTTTGATGAAGATAAACTGGCATTCTCTAAAACTCAACATATA AATAATTGGCTTACAAATTTAGATGCTTCAAATACTCAGAATGTCACAGCTTTCTCAGATATTTTAAGTAAATCTAATGTTCTGCCTTCA TGGGAATATTTTAATAGTAAAGAACAAAATCCATCTCCTTTGAATGGAACAGTGGAAAGAGCCACAAATACTGCTAATAATTCAGTACCC TTTGTATCTAGCCCACCCATGTTTGTACTAGATAAAAAATGTGAAAAGACCTCTGAAACTAGCACTATGAGGACAACTGACTCCACTTCT GGAGCATTCAAAAGAGAGAGACCATTAGTTACTGAGAGCCCAACATTTAAATTTAGCAAATCCCAAAGCACTTCAGATTCTCTAACCCAG GAAGTGGCTACATTTCCAGACCAAGAGAAATATTCTGAATTAAATCAAGAAAATGGAACTACTTCAATTCCTACTTCATGTGTACCAGTG GCAACGCCTTTAGTTTTGCCATCTAATATACAGTCAGCTAGACCTTCAGCAAAGAACAGTATACACATAAAAGAAATTGATGCAGTGCAG TGTTCTGATAAGTTAGATGAATTGAAAGATGGTAAAGAAGAAGAGATAAAATATTTTAATTGCAATAAGGAAGAGTTGCCTTTATTTTCA GACAGTTTTCAAGATGCCTATATACCTCACAATCCTGATTCAAAAGATGAAAAACAAAAATTAGCTGAAACATCATCCTTGTCTAATGTA ACTTCTAATTATGACTTTGTTGGCCAGCATAAGAAAATGAAATACAACATCCATGAGAGAAATGGTGTGAGATTTCTTAAAAGTATTTTA AAGAAAGAATCTAAATATGAACATGGTTATCTTAAGGCATTAATTATAAATCAGAGCTTTAAGTTTGGAAATCAAAAAGCAGCAGCTATC AGAGATAGTATTGAATTAACAAAGGAAAAAGGTGCAGAAATTCCAAAGACCATTAAAAAACTGAGGTGGTTTGATGAAACTAGCAATATA GAAAACAATGCTGAAAACAGTCATTCACTGAAGAATAAAACAGGAACAACTCAACAGCATTCTCAACAATTCCACATTCAAAGTGGTGCT GGAAGCAACATAATTAGTGTTTCTACTTGTGCTGTAAATTCTGCTGATACAAAGAAGTCCAGGGAGGATTCTATCTCTGAAAATGTTACG ACTTTAGGAGGATCTGGAGCAGACCATATGCCTTTGAACTGTTTTATACCTTCAGGTTATAACTTTGCTAAACATGCCTGGCCAGCCTCA AAAAAAGAAGAAAGTAAAATCCCTGTACATGATGATTCTAAAACTAAGCAAGGTAAGCCACAAAGAGGTAGAGCAAAAATAATTAGAAAA CCAGGATCTGCAAAAGTCCAATCAGGCTTTATATGTACAAACAGAAAAGGCGCTGTCATTCAACCACAGTCTGCAAGCAAAGTCAACATA TTTACACAAGCTCAGGGAAAATTAATTATACCTTGTCCTCCTCCTCAATCTACATCAAATATTAGAAGTGGTAAAAATATACAAGTGTCT CAGTGTCAACCAGTAACTCCTGAAAATCCTCAAAACATTATTACACATAACTCTTTTAATTCAAAACATGTGCTTCCAACAGAACACAGT TTGAATCAGTGGAATCAGGAAAGTAGTTCTCCACTCTCAAATGCTTGTTCTGACCTAGTCACTGTGATACCATCACTGCCATCATATTGT TCTTCAGAGTGCCAAACTTTCGCAAAAATAAATCATTCAAATGGCACTCAAGCAGTTGCCCGGCAAGATGCGACATTATATTGCACCCAA AGAAGTCCTGTTTGTGAAGAAAGTTATCCGTCTGTGACTCTAAGAACTGCTGAAGAAGAATCAGTTCCCTTATGGAAAAGAGGTCCTAAT GTCCTGCATCAAAATAAGAGGGCTACAGGGTCTACTGTTATGAGAAGAAAACGAATTGCTGAAACTAAGCGGAGAAATATTTTAGAGCAG AAAAGACAAAACCCTGGATCTGTAGGACAGAAGTACAGTGAGCAAATTAATAATTTTGGACAAAGTGTCCTGCTAAGTTCAAGTGAGCCA AAACAAACTACAAGGGGTACTTCTTATATTGAAGAAGTTTCAGATAGTACTTCTGAGTTTTTGATGGCTGAAAACTTAGTGAAAGCATCA GTGCCGGAGGATGAGATTCTGACTGTCTTGAATAGCAAACAGATACAGAAATCAAATCTACCTTTAAATAAAACTCAACAATTCAACATC TGCACACTGTCAGCTGAAGAACAGAAGATCCTAGAGTCCCTTAATGATCTCAGTGAAAGACTACATTATATACAAGAATCCATTTGCAAA AACCCATCCATCAAAAATACTTTACAAATAATACCACTTCTGGAGAAGAGAGAAGATAGAACCAGCAGCTGCAGAGACAAGAGATAATTC CAGCAGAATCCGTCTAAGAAGACCTTTCATGTACTTCCCTAGGACTAGATGCATACCGTTTTGTGAAAACCAGCCATAGGAAAACATGTG AGCAACAACCCCCATGAACATTTGTCCTAACTCAGATTTTGTGAGCAGTGAAGTTTAACAGAGCAGTGACATTTAACAAAGCAGTGAAGT TTAACAGAGTTCTGAGAATACCATGAAAGACATTATGCCTGCCTAAACAAAAAGCAGGACATAACCTAGCTCTGAATACATGCCACAAGG ATGAAGCTTGTGAGTAGAGCAAACAAACGTTTTTCCAAAGAATTCACAGTGCTCCTTTGCAATTTATAGATTTCATGTTGAAATATATGT TAAATAAAATTTCTGTTTATTGAACCTCTTTATTAAACCTCTAACTTACTGATAAGATGTTTATGAAGTATGGCATATTTTGATTTTTTT AATTGTAATAAATATTCTTAAAGTTACCACATCCCACAAAATGGCCCTTGGTGGCAGCAATAGAGCAAAGGTTACCTTTTTGTATGGTGA AGGGAGGCCTTCCTATGGCTGTACAATTACATCGATTCTTCCAAATTTCATATTTCATACATGGCACTTTGGCATACCGAAAAAACATGA AATTTTTCATTAAAATGCCATGAATCAAGCCAGGGCCGTTGGCTTATGCCTGTAATCCCAGCACTTTGCAGGCCGAGGTAGACAGATGGC TTGAGCTCAGGAGTTCGTGACCAGCCTGGGCAACCCTGTCTCTACAAAAAATACAAAAATTAACCAGGCATGGTGGCATGCACCTGTAGT CCCAGCTACTTGGGGTGCTGAGGCGGGAGGATTACTTGAGCCCAGGAGGATTACTTCAACCTGGGAGGTTGAGGCTGCAGTGAGCTGTGT TTCGCCACTGCACACCAGCCTGGGTGACAGTGTGAGACCCAGCCTCAAAAAAAAAAAAAAAAAAGTGATGAATCAAAATTAGAAATTAAG AGTTTTAAGAAAACATGTGGCCTTTTATTAATAACACTACTAAATTTTGGTTCCTCCATAGAATTAGTTTTGAAACACTTGATGTAGTGA GAAATGCATTAACATGTTGAATGCCTACCATGTACCAAATTTTGTGCATATATTTTTTATTTAATCTGACCAGCCACCCAAACCATGGGT ATTTTTGTCTCCACTTTAGAGATGAGAAACTGAGCCAAGGCCACATAGCTACCTACAGTGACAGAATCAAAATTCAAACTCAGGTTTATC TAGTTCCAAAACCCATGTTCTTTCTGCCACACCATGTTAGTAGAAATGGAAACTATTGGATGAAATGAGGAAAAACAGGAAAAGAATTCA CTTTTTAAATGAAGAAATTAGTGAAAAAATTGACCTAATGAAGGAAACATTTGTGCTTTCCTATATTTTTAATTTTAAGAATAGGATTTC GGAAGGCGACAGAAAATTTAGTTCTTAGACATTTAAATAGAAAGTTGTGTGCCCCTATAGAAAATATTTGAGAATTTCTTATACTATCAA GAAAAAATTCTGTGAATTAAGATGTAATTTATAAAATAACATTTCAATGGGGGTAAACAGGCCAGAAGAGTGTGCCAAGTTGTTTGTGAA TCATTCCAAGCACCTCAGATGAAAACTCACTTTTATTAAAAAAAAAAAAGACAAGGGTTTATATTCATATACACTAGTATATATGTACAC AGCAGCATCCTGCATGCCAAAGTAGCTTCACCGTTAGTAATCCCTCACTTTAATACCTCTTAGGAACCAAAGAATGCCTCTACAAGCAAA AAGATAGTTGAAAATAGTTAAGATCCAAAGTCAGAATAGGCCAAAAAAAAAAAAAAAAAAAGCCTAAATAGTAAGCTGGTGAAACAAGAT AAGATTTGCATTTTACTAGAACTTGCACATTATGATATTGTCCTTTTATGAAACTGTCATATGACCAGAATTCTTCTGTAATTCTGCCCA TGACTCCTCCAGAATTTTAGTAGATACAGGGTGGGTTCATTAAGAGTGATAAAAGTGGGAAGACATAAAGAGCCTTTGTGAATTAAAGTG GAAGAGAATAACACTTTGCATGCTATAAACGTGAAAACTAACATTTTTGGCCAGACACAGTGGCTCATGCATGTAATTCTAGCACTTTGG AGGCCAAGGCAGGAGGACTGCTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAATGTAGCAAGACCCCATCTCTATATAAAATATAAAAA TGTTGGCTGTGCACGGTAGCTTATGCCTGTAATCTCAGCACTTTGGGAGGCCAAGGCAGGCAGATCATGAGGTCAAGAGATCAAGACCAT CCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATAGCTGGGCATGGTGGCACGCACCTCTACTCCCAGCTACTAGGAG GCTGAGGCAGGAGAATCGTTTGAACCCAGGAGGTAGAGGTTGCAGTGAGCTGAGATTGCACCACTGCACCAGCCTGGCAACAGAGCAAGA CTCCGTCTCACAAAAATGAATAAATAAAATAAAAATAAAAATGTTACTTTTTAAAAAGTAACTTTTTTAATAATATAAGAAAGAAAAATG CCCTTTCACACTGAATCTTCAAGTTCTAAGGAAGAAAAGAGTCTCCTTTCGAATGTGAAGAAGTAAATTTAGAGGAAATCAAACAAGCAT CACTTTCCTCAGTGGAAAAACTTATGAAACTTCTTATAAGAGAGAGTAATCTCAGGCCGGACATGCTGGCTCATACCTGTAATCCCAGAA CTTTGGGAGGCCGAGGCAGGTGGATCATTTGAGCTCAGGAATTCAAGACCAGCCTGGGTAATATGGCAAGAGCCCAACTCTACTAAAAAT ACAAAAAGAAAAGAAAACAGCCAAGCTTGGTGGTATGTGCCTGTGGTCCCAGCTACTGGGGAGGCTGAGGTGGGAGGATCGTTTGAGCCT GGGAGGCAGAGGTTGCAGTGATCAGGAATTGTGCCACTGCACTCCAACCTGAGTGACAGAGCAACACTCTGTCTTAAAAGAAAAAAAAAA AAGAGAGAGATAGTAATCTCTTGGGCAAAAGGTATCAAATAATTGAAAGAAAAGTTTAAACACATTTCCGAGAGGCAGGGCAACTAATAA CTGGTCAGAAAAATTTAGACGGTCTTCATTTTAAAATTGGCATCAGGAAGGATTACCATGAACTTATTTTAAATCCATATTGTACCAGAA TGACTATGTCTGTGTTTCTTAGGAATGTTGAAGCTTTTTGTGAAAACTGTACTGTATACATATATAAATATACACACACTTACATGTATG >In-frame_ENST00000361236_ENST00000263468_TCGA-GD-A3OS-01A_TMEM123_chr11_102272270_-_KIAA1377_chr11_101814996_length(amino acids)=1280AA_start in transcript=24_stop in transcript=3866 MRTRRPLQAPLLRPIWSFGGQAAGGETCAAEGEAEPAPAAQRSRSRRRHLGWEPTRLPHPALGTMGLGARGAWAALLLGTLQVLALLGAA HESAAMAETLQHVPSDHTNETSNSTVKPPTSVASDSSNTTVTTMKPTAASNTTTPGMVSTNMTSTTLKSTPKTTSVSQNTSQISTSTMTV THNSSVTSAASSVTITTTMHSEAKKGSKFDTGSFVGGIVLTLGVLSILYIGCKMYYSRRGIRYRTIAFEEKRKEQEEKEHQIREQILQQR KQKFEEVTEKFQRAHVPLSQRRKAVSRKPVPPLEEALKQIQESNLKSEVNLPFSRRPTINWRAIDSALPSALSKNDHKHQKQLLSKINCE KEMNENMRATLATSKNVFQLKLEETQKLLEDQHLSNLQKFGDEVNQITNSETLSSIDSLEATEHEEIYLTLNKEHSTSIQRNTISLKPAN MQSTNLSCFDEDKLAFSKTQHINNWLTNLDASNTQNVTAFSDILSKSNVLPSWEYFNSKEQNPSPLNGTVERATNTANNSVPFVSSPPMF VLDKKCEKTSETSTMRTTDSTSGAFKRERPLVTESPTFKFSKSQSTSDSLTQEVATFPDQEKYSELNQENGTTSIPTSCVPVATPLVLPS NIQSARPSAKNSIHIKEIDAVQCSDKLDELKDGKEEEIKYFNCNKEELPLFSDSFQDAYIPHNPDSKDEKQKLAETSSLSNVTSNYDFVG QHKKMKYNIHERNGVRFLKSILKKESKYEHGYLKALIINQSFKFGNQKAAAIRDSIELTKEKGAEIPKTIKKLRWFDETSNIENNAENSH SLKNKTGTTQQHSQQFHIQSGAGSNIISVSTCAVNSADTKKSREDSISENVTTLGGSGADHMPLNCFIPSGYNFAKHAWPASKKEESKIP VHDDSKTKQGKPQRGRAKIIRKPGSAKVQSGFICTNRKGAVIQPQSASKVNIFTQAQGKLIIPCPPPQSTSNIRSGKNIQVSQCQPVTPE NPQNIITHNSFNSKHVLPTEHSLNQWNQESSSPLSNACSDLVTVIPSLPSYCSSECQTFAKINHSNGTQAVARQDATLYCTQRSPVCEES YPSVTLRTAEEESVPLWKRGPNVLHQNKRATGSTVMRRKRIAETKRRNILEQKRQNPGSVGQKYSEQINNFGQSVLLSSSEPKQTTRGTS YIEEVSDSTSEFLMAENLVKASVPEDEILTVLNSKQIQKSNLPLNKTQQFNICTLSAEEQKILESLNDLSERLHYIQESICKNPSIKNTL -------------------------------------------------------------- >In-frame_ENST00000398136_ENST00000263468_TCGA-GD-A3OS-01A_TMEM123_chr11_102272270_-_KIAA1377_chr11_101814996_length(transcript)=7544nt_BP=1023nt AAAGGCTTCCTTCCGGGCACCGCGAAGCCAGCGTGCTCAGCATTCAGGGAGGCAGCGGCGCTCGCCTTCATCCAGGACAACAAAACTGCC ATTTCCGAAGAGAAAGGAAACGGCTCGCGGTTTCTGGGGTTCCCAAGCGCGCGCCTGCGAGGGAGGCCGCGAGCCGAGTCGCCACGCCCA GAACCCCGAGCCCGCCCCCGCGCCACCCAGCCCGGCCCCGCCGCCCCGGCTGCGCACGCGACGCCCCCTCCAGGCCCCGCTCCTGCGCCC TATTTGGTCATTCGGGGGGCAAGCGGCGGGAGGGGAAACGTGCGCGGCCGAAGGGGAAGCGGAGCCGGCGCCGGCTGCGCAGAGGAGCCG CTCTCGCCGCCGCCACCTCGGCTGGGAGCCCACGAGGCTGCCGCATCCTGCCCTCGGAACAATGGGACTCGGCGCGCGAGGTGCTTGGGC CGCGCTGCTCCTGGGGACGCTGCAGGTGCTAGCGCTGCTGGGGGCCGCCCATGAAAGCGCAGCCATGGCGGCATCTGCAAACATAGAGAA TTCTGGGCTTCCACACAACTCCAGTGCTAACTCAACAGAGACTCTCCAACATGTGCCTTCTGACCATACAAATGAAACTTCCAACAGTAC TGTGAAACCACCAACTTCAGTTGCCTCAGACTCCAGTAATACAACGGTCACCACCATGAAACCTACAGCGGCATCTAATACAACAACACC AGGGATGGTCTCAACAAATATGACTTCTACCACCTTAAAGTCTACACCCAAAACAACAAGTGTTTCACAGAACACATCTCAGATATCAAC ATCCACAATGACCGTAACCCACAATAGTTCAGTGACATCTGCTGCTTCATCAGTAACAATCACAACAACTATGCATTCTGAAGCAAAGAA AGGATCAAAATTTGATACTGGGAGCTTTGTTGGTGGTATTGTATTAACGCTGGGAGTTTTATCTATTCTTTACATTGGATGCAAAATGTA TTACTCAAGAAGAGGCATTCGGTATCGAACCATAGCTTTTGAGGAGAAACGAAAAGAACAGGAAGAAAAAGAACACCAAATTAGAGAACA AATACTTCAACAAAGAAAACAGAAGTTTGAAGAAGTTACTGAAAAATTCCAGCGTGCCCATGTTCCTCTTTCACAGCGGAGGAAAGCAGT TTCCCGAAAACCAGTTCCTCCATTAGAAGAGGCCCTCAAACAAATTCAGGAATCCAACTTAAAATCAGAAGTAAACCTTCCCTTTTCCCG TAGACCAACAATAAACTGGAGAGCTATAGATTCTGCCTTGCCTTCCGCATTATCAAAAAATGATCACAAGCATCAGAAACAACTCTTATC CAAAATCAATTGTGAGAAAGAAATGAATGAAAACATGAGGGCAACCTTGGCTACTAGCAAAAATGTGTTCCAGCTTAAACTGGAGGAAAC TCAGAAACTCCTCGAAGATCAACATCTAAGCAATTTGCAAAAATTTGGTGATGAAGTTAATCAGATAACCAATTCTGAAACCCTCTCAAG TATAGACAGTCTTGAGGCTACAGAGCATGAAGAAATATATTTAACACTTAATAAGGAGCATTCCACATCCATCCAGCGGAATACCATTTC CCTCAAACCAGCAAATATGCAATCAACTAATCTCAGCTGCTTTGATGAAGATAAACTGGCATTCTCTAAAACTCAACATATAAATAATTG GCTTACAAATTTAGATGCTTCAAATACTCAGAATGTCACAGCTTTCTCAGATATTTTAAGTAAATCTAATGTTCTGCCTTCATGGGAATA TTTTAATAGTAAAGAACAAAATCCATCTCCTTTGAATGGAACAGTGGAAAGAGCCACAAATACTGCTAATAATTCAGTACCCTTTGTATC TAGCCCACCCATGTTTGTACTAGATAAAAAATGTGAAAAGACCTCTGAAACTAGCACTATGAGGACAACTGACTCCACTTCTGGAGCATT CAAAAGAGAGAGACCATTAGTTACTGAGAGCCCAACATTTAAATTTAGCAAATCCCAAAGCACTTCAGATTCTCTAACCCAGGAAGTGGC TACATTTCCAGACCAAGAGAAATATTCTGAATTAAATCAAGAAAATGGAACTACTTCAATTCCTACTTCATGTGTACCAGTGGCAACGCC TTTAGTTTTGCCATCTAATATACAGTCAGCTAGACCTTCAGCAAAGAACAGTATACACATAAAAGAAATTGATGCAGTGCAGTGTTCTGA TAAGTTAGATGAATTGAAAGATGGTAAAGAAGAAGAGATAAAATATTTTAATTGCAATAAGGAAGAGTTGCCTTTATTTTCAGACAGTTT TCAAGATGCCTATATACCTCACAATCCTGATTCAAAAGATGAAAAACAAAAATTAGCTGAAACATCATCCTTGTCTAATGTAACTTCTAA TTATGACTTTGTTGGCCAGCATAAGAAAATGAAATACAACATCCATGAGAGAAATGGTGTGAGATTTCTTAAAAGTATTTTAAAGAAAGA ATCTAAATATGAACATGGTTATCTTAAGGCATTAATTATAAATCAGAGCTTTAAGTTTGGAAATCAAAAAGCAGCAGCTATCAGAGATAG TATTGAATTAACAAAGGAAAAAGGTGCAGAAATTCCAAAGACCATTAAAAAACTGAGGTGGTTTGATGAAACTAGCAATATAGAAAACAA TGCTGAAAACAGTCATTCACTGAAGAATAAAACAGGAACAACTCAACAGCATTCTCAACAATTCCACATTCAAAGTGGTGCTGGAAGCAA CATAATTAGTGTTTCTACTTGTGCTGTAAATTCTGCTGATACAAAGAAGTCCAGGGAGGATTCTATCTCTGAAAATGTTACGACTTTAGG AGGATCTGGAGCAGACCATATGCCTTTGAACTGTTTTATACCTTCAGGTTATAACTTTGCTAAACATGCCTGGCCAGCCTCAAAAAAAGA AGAAAGTAAAATCCCTGTACATGATGATTCTAAAACTAAGCAAGGTAAGCCACAAAGAGGTAGAGCAAAAATAATTAGAAAACCAGGATC TGCAAAAGTCCAATCAGGCTTTATATGTACAAACAGAAAAGGCGCTGTCATTCAACCACAGTCTGCAAGCAAAGTCAACATATTTACACA AGCTCAGGGAAAATTAATTATACCTTGTCCTCCTCCTCAATCTACATCAAATATTAGAAGTGGTAAAAATATACAAGTGTCTCAGTGTCA ACCAGTAACTCCTGAAAATCCTCAAAACATTATTACACATAACTCTTTTAATTCAAAACATGTGCTTCCAACAGAACACAGTTTGAATCA GTGGAATCAGGAAAGTAGTTCTCCACTCTCAAATGCTTGTTCTGACCTAGTCACTGTGATACCATCACTGCCATCATATTGTTCTTCAGA GTGCCAAACTTTCGCAAAAATAAATCATTCAAATGGCACTCAAGCAGTTGCCCGGCAAGATGCGACATTATATTGCACCCAAAGAAGTCC TGTTTGTGAAGAAAGTTATCCGTCTGTGACTCTAAGAACTGCTGAAGAAGAATCAGTTCCCTTATGGAAAAGAGGTCCTAATGTCCTGCA TCAAAATAAGAGGGCTACAGGGTCTACTGTTATGAGAAGAAAACGAATTGCTGAAACTAAGCGGAGAAATATTTTAGAGCAGAAAAGACA AAACCCTGGATCTGTAGGACAGAAGTACAGTGAGCAAATTAATAATTTTGGACAAAGTGTCCTGCTAAGTTCAAGTGAGCCAAAACAAAC TACAAGGGGTACTTCTTATATTGAAGAAGTTTCAGATAGTACTTCTGAGTTTTTGATGGCTGAAAACTTAGTGAAAGCATCAGTGCCGGA GGATGAGATTCTGACTGTCTTGAATAGCAAACAGATACAGAAATCAAATCTACCTTTAAATAAAACTCAACAATTCAACATCTGCACACT GTCAGCTGAAGAACAGAAGATCCTAGAGTCCCTTAATGATCTCAGTGAAAGACTACATTATATACAAGAATCCATTTGCAAAAACCCATC CATCAAAAATACTTTACAAATAATACCACTTCTGGAGAAGAGAGAAGATAGAACCAGCAGCTGCAGAGACAAGAGATAATTCCAGCAGAA TCCGTCTAAGAAGACCTTTCATGTACTTCCCTAGGACTAGATGCATACCGTTTTGTGAAAACCAGCCATAGGAAAACATGTGAGCAACAA CCCCCATGAACATTTGTCCTAACTCAGATTTTGTGAGCAGTGAAGTTTAACAGAGCAGTGACATTTAACAAAGCAGTGAAGTTTAACAGA GTTCTGAGAATACCATGAAAGACATTATGCCTGCCTAAACAAAAAGCAGGACATAACCTAGCTCTGAATACATGCCACAAGGATGAAGCT TGTGAGTAGAGCAAACAAACGTTTTTCCAAAGAATTCACAGTGCTCCTTTGCAATTTATAGATTTCATGTTGAAATATATGTTAAATAAA ATTTCTGTTTATTGAACCTCTTTATTAAACCTCTAACTTACTGATAAGATGTTTATGAAGTATGGCATATTTTGATTTTTTTAATTGTAA TAAATATTCTTAAAGTTACCACATCCCACAAAATGGCCCTTGGTGGCAGCAATAGAGCAAAGGTTACCTTTTTGTATGGTGAAGGGAGGC CTTCCTATGGCTGTACAATTACATCGATTCTTCCAAATTTCATATTTCATACATGGCACTTTGGCATACCGAAAAAACATGAAATTTTTC ATTAAAATGCCATGAATCAAGCCAGGGCCGTTGGCTTATGCCTGTAATCCCAGCACTTTGCAGGCCGAGGTAGACAGATGGCTTGAGCTC AGGAGTTCGTGACCAGCCTGGGCAACCCTGTCTCTACAAAAAATACAAAAATTAACCAGGCATGGTGGCATGCACCTGTAGTCCCAGCTA CTTGGGGTGCTGAGGCGGGAGGATTACTTGAGCCCAGGAGGATTACTTCAACCTGGGAGGTTGAGGCTGCAGTGAGCTGTGTTTCGCCAC TGCACACCAGCCTGGGTGACAGTGTGAGACCCAGCCTCAAAAAAAAAAAAAAAAAAGTGATGAATCAAAATTAGAAATTAAGAGTTTTAA GAAAACATGTGGCCTTTTATTAATAACACTACTAAATTTTGGTTCCTCCATAGAATTAGTTTTGAAACACTTGATGTAGTGAGAAATGCA TTAACATGTTGAATGCCTACCATGTACCAAATTTTGTGCATATATTTTTTATTTAATCTGACCAGCCACCCAAACCATGGGTATTTTTGT CTCCACTTTAGAGATGAGAAACTGAGCCAAGGCCACATAGCTACCTACAGTGACAGAATCAAAATTCAAACTCAGGTTTATCTAGTTCCA AAACCCATGTTCTTTCTGCCACACCATGTTAGTAGAAATGGAAACTATTGGATGAAATGAGGAAAAACAGGAAAAGAATTCACTTTTTAA ATGAAGAAATTAGTGAAAAAATTGACCTAATGAAGGAAACATTTGTGCTTTCCTATATTTTTAATTTTAAGAATAGGATTTCGGAAGGCG ACAGAAAATTTAGTTCTTAGACATTTAAATAGAAAGTTGTGTGCCCCTATAGAAAATATTTGAGAATTTCTTATACTATCAAGAAAAAAT TCTGTGAATTAAGATGTAATTTATAAAATAACATTTCAATGGGGGTAAACAGGCCAGAAGAGTGTGCCAAGTTGTTTGTGAATCATTCCA AGCACCTCAGATGAAAACTCACTTTTATTAAAAAAAAAAAAGACAAGGGTTTATATTCATATACACTAGTATATATGTACACAGCAGCAT CCTGCATGCCAAAGTAGCTTCACCGTTAGTAATCCCTCACTTTAATACCTCTTAGGAACCAAAGAATGCCTCTACAAGCAAAAAGATAGT TGAAAATAGTTAAGATCCAAAGTCAGAATAGGCCAAAAAAAAAAAAAAAAAAAGCCTAAATAGTAAGCTGGTGAAACAAGATAAGATTTG CATTTTACTAGAACTTGCACATTATGATATTGTCCTTTTATGAAACTGTCATATGACCAGAATTCTTCTGTAATTCTGCCCATGACTCCT CCAGAATTTTAGTAGATACAGGGTGGGTTCATTAAGAGTGATAAAAGTGGGAAGACATAAAGAGCCTTTGTGAATTAAAGTGGAAGAGAA TAACACTTTGCATGCTATAAACGTGAAAACTAACATTTTTGGCCAGACACAGTGGCTCATGCATGTAATTCTAGCACTTTGGAGGCCAAG GCAGGAGGACTGCTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAATGTAGCAAGACCCCATCTCTATATAAAATATAAAAATGTTGGCT GTGCACGGTAGCTTATGCCTGTAATCTCAGCACTTTGGGAGGCCAAGGCAGGCAGATCATGAGGTCAAGAGATCAAGACCATCCTGGCCA ACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATAGCTGGGCATGGTGGCACGCACCTCTACTCCCAGCTACTAGGAGGCTGAGGC AGGAGAATCGTTTGAACCCAGGAGGTAGAGGTTGCAGTGAGCTGAGATTGCACCACTGCACCAGCCTGGCAACAGAGCAAGACTCCGTCT CACAAAAATGAATAAATAAAATAAAAATAAAAATGTTACTTTTTAAAAAGTAACTTTTTTAATAATATAAGAAAGAAAAATGCCCTTTCA CACTGAATCTTCAAGTTCTAAGGAAGAAAAGAGTCTCCTTTCGAATGTGAAGAAGTAAATTTAGAGGAAATCAAACAAGCATCACTTTCC TCAGTGGAAAAACTTATGAAACTTCTTATAAGAGAGAGTAATCTCAGGCCGGACATGCTGGCTCATACCTGTAATCCCAGAACTTTGGGA GGCCGAGGCAGGTGGATCATTTGAGCTCAGGAATTCAAGACCAGCCTGGGTAATATGGCAAGAGCCCAACTCTACTAAAAATACAAAAAG AAAAGAAAACAGCCAAGCTTGGTGGTATGTGCCTGTGGTCCCAGCTACTGGGGAGGCTGAGGTGGGAGGATCGTTTGAGCCTGGGAGGCA GAGGTTGCAGTGATCAGGAATTGTGCCACTGCACTCCAACCTGAGTGACAGAGCAACACTCTGTCTTAAAAGAAAAAAAAAAAAGAGAGA GATAGTAATCTCTTGGGCAAAAGGTATCAAATAATTGAAAGAAAAGTTTAAACACATTTCCGAGAGGCAGGGCAACTAATAACTGGTCAG AAAAATTTAGACGGTCTTCATTTTAAAATTGGCATCAGGAAGGATTACCATGAACTTATTTTAAATCCATATTGTACCAGAATGACTATG TCTGTGTTTCTTAGGAATGTTGAAGCTTTTTGTGAAAACTGTACTGTATACATATATAAATATACACACACTTACATGTATGTATTTTGA >In-frame_ENST00000398136_ENST00000263468_TCGA-GD-A3OS-01A_TMEM123_chr11_102272270_-_KIAA1377_chr11_101814996_length(amino acids)=1347AA_start in transcript=85_stop in transcript=4128 MPFPKRKETARGFWGSQARACEGGREPSRHAQNPEPAPAPPSPAPPPRLRTRRPLQAPLLRPIWSFGGQAAGGETCAAEGEAEPAPAAQR SRSRRRHLGWEPTRLPHPALGTMGLGARGAWAALLLGTLQVLALLGAAHESAAMAASANIENSGLPHNSSANSTETLQHVPSDHTNETSN STVKPPTSVASDSSNTTVTTMKPTAASNTTTPGMVSTNMTSTTLKSTPKTTSVSQNTSQISTSTMTVTHNSSVTSAASSVTITTTMHSEA KKGSKFDTGSFVGGIVLTLGVLSILYIGCKMYYSRRGIRYRTIAFEEKRKEQEEKEHQIREQILQQRKQKFEEVTEKFQRAHVPLSQRRK AVSRKPVPPLEEALKQIQESNLKSEVNLPFSRRPTINWRAIDSALPSALSKNDHKHQKQLLSKINCEKEMNENMRATLATSKNVFQLKLE ETQKLLEDQHLSNLQKFGDEVNQITNSETLSSIDSLEATEHEEIYLTLNKEHSTSIQRNTISLKPANMQSTNLSCFDEDKLAFSKTQHIN NWLTNLDASNTQNVTAFSDILSKSNVLPSWEYFNSKEQNPSPLNGTVERATNTANNSVPFVSSPPMFVLDKKCEKTSETSTMRTTDSTSG AFKRERPLVTESPTFKFSKSQSTSDSLTQEVATFPDQEKYSELNQENGTTSIPTSCVPVATPLVLPSNIQSARPSAKNSIHIKEIDAVQC SDKLDELKDGKEEEIKYFNCNKEELPLFSDSFQDAYIPHNPDSKDEKQKLAETSSLSNVTSNYDFVGQHKKMKYNIHERNGVRFLKSILK KESKYEHGYLKALIINQSFKFGNQKAAAIRDSIELTKEKGAEIPKTIKKLRWFDETSNIENNAENSHSLKNKTGTTQQHSQQFHIQSGAG SNIISVSTCAVNSADTKKSREDSISENVTTLGGSGADHMPLNCFIPSGYNFAKHAWPASKKEESKIPVHDDSKTKQGKPQRGRAKIIRKP GSAKVQSGFICTNRKGAVIQPQSASKVNIFTQAQGKLIIPCPPPQSTSNIRSGKNIQVSQCQPVTPENPQNIITHNSFNSKHVLPTEHSL NQWNQESSSPLSNACSDLVTVIPSLPSYCSSECQTFAKINHSNGTQAVARQDATLYCTQRSPVCEESYPSVTLRTAEEESVPLWKRGPNV LHQNKRATGSTVMRRKRIAETKRRNILEQKRQNPGSVGQKYSEQINNFGQSVLLSSSEPKQTTRGTSYIEEVSDSTSEFLMAENLVKASV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for TMEM123-KIAA1377 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for TMEM123-KIAA1377 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for TMEM123-KIAA1377 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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