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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMEM123-MMP20 (FusionGDB2 ID:90961)

Fusion Gene Summary for TMEM123-MMP20

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM123-MMP20
Fusion gene ID: 90961
HgeneTgene
Gene symbol

TMEM123

MMP20

Gene ID

114908

64386

Gene nametransmembrane protein 123matrix metallopeptidase 25
SynonymsKCT3|PORIMIN|PORMINMMP-25|MMP20|MMP20A|MMPL1|MT-MMP 6|MT-MMP6|MT6-MMP|MT6MMP|MTMMP6
Cytomap

11q22.2

16p13.3

Type of geneprotein-codingprotein-coding
DescriptionporiminKCT-3keratinocytes associated transmembrane protein 3pro-oncosis receptor inducing membrane injuryserine/threonine-rich receptormatrix metalloproteinase-25leukolysinmatrix metallopeptidase-like 1matrix metalloproteinase 20matrix metalloproteinase-like 1membrane-type 6 matrix metalloproteinasemembrane-type matrix metalloproteinase 6
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000361236, ENST00000398136, 
ENST00000532161, ENST00000525577, 
ENST00000260228, ENST00000544938, 
Fusion gene scores* DoF score16 X 10 X 10=16002 X 5 X 5=50
# samples 277
** MAII scorelog2(27/1600*10)=-2.56704059272389
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/50*10)=0.485426827170242
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TMEM123 [Title/Abstract] AND MMP20 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMEM123(102319543)-MMP20(102480761), # samples:4
TMEM123(102319543)-MMP20(102449873), # samples:4
Anticipated loss of major functional domain due to fusion event.TMEM123-MMP20 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMEM123

GO:0070267

oncosis

9600958|11481458


check buttonFusion gene breakpoints across TMEM123 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MMP20 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-CA-5254TMEM123chr11

102319542

-MMP20chr11

102464326

-
ChimerDB4STADTCGA-CD-8527TMEM123chr11

102319542

-MMP20chr11

102449873

-
ChimerDB4UCECTCGA-D1-A1NUTMEM123chr11

102319542

-MMP20chr11

102449873

-
ChimerDB4COADTCGA-CA-5254-01ATMEM123chr11

102319543

-MMP20chr11

102464326

-
ChimerDB4LUADTCGA-35-4122-01ATMEM123chr11

102319543

-MMP20chr11

102480761

-
ChimerDB4OVTCGA-25-2397-01ATMEM123chr11

102319543

-MMP20chr11

102449873

-
ChimerDB4STADTCGA-BR-A4QI-01ATMEM123chr11

102319543

-MMP20chr11

102482634

-
ChimerDB4STADTCGA-BR-A4QI-01ATMEM123chr11

102319543

-MMP20chr11

102480761

-
ChimerDB4STADTCGA-BR-A4QI-01ATMEM123chr11

102319543

-MMP20chr11

102487790

-
ChimerDB4STADTCGA-CD-8527-01ATMEM123chr11

102319543

-MMP20chr11

102449873

-
ChimerDB4UCECTCGA-D1-A1NU-01ATMEM123chr11

102319543

-MMP20chr11

102449873

-
ChimerDB4LUADTCGA-35-4122-01ATMEM123chr11

102319543

-MMP20chr11

102480761

-
ChimerDB4COADTCGA-CA-5254-01ATMEM123chr11

102319543

-MMP20chr11

102464326

-
ChimerDB4STADTCGA-CD-8527-01ATMEM123chr11

102319543

-MMP20chr11

102449873

-
ChimerDB4BRCATCGA-OL-A66I-01ATMEM123chr11

102319543

-MMP20chr11

102480761

-


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Fusion Gene ORF analysis for TMEM123-MMP20

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000361236ENST00000260228TMEM123chr11

102319542

-MMP20chr11

102464326

-
intron-intronENST00000361236ENST00000544938TMEM123chr11

102319542

-MMP20chr11

102464326

-
In-frameENST00000398136ENST00000260228TMEM123chr11

102319542

-MMP20chr11

102464326

-
5CDS-intronENST00000398136ENST00000544938TMEM123chr11

102319542

-MMP20chr11

102464326

-
5UTR-3CDSENST00000532161ENST00000260228TMEM123chr11

102319542

-MMP20chr11

102464326

-
5UTR-intronENST00000532161ENST00000544938TMEM123chr11

102319542

-MMP20chr11

102464326

-
5UTR-3CDSENST00000525577ENST00000260228TMEM123chr11

102319542

-MMP20chr11

102464326

-
5UTR-intronENST00000525577ENST00000544938TMEM123chr11

102319542

-MMP20chr11

102464326

-
intron-3CDSENST00000361236ENST00000260228TMEM123chr11

102319542

-MMP20chr11

102449873

-
intron-intronENST00000361236ENST00000544938TMEM123chr11

102319542

-MMP20chr11

102449873

-
Frame-shiftENST00000398136ENST00000260228TMEM123chr11

102319542

-MMP20chr11

102449873

-
5CDS-intronENST00000398136ENST00000544938TMEM123chr11

102319542

-MMP20chr11

102449873

-
5UTR-3CDSENST00000532161ENST00000260228TMEM123chr11

102319542

-MMP20chr11

102449873

-
5UTR-intronENST00000532161ENST00000544938TMEM123chr11

102319542

-MMP20chr11

102449873

-
5UTR-3CDSENST00000525577ENST00000260228TMEM123chr11

102319542

-MMP20chr11

102449873

-
5UTR-intronENST00000525577ENST00000544938TMEM123chr11

102319542

-MMP20chr11

102449873

-
intron-3CDSENST00000361236ENST00000260228TMEM123chr11

102319543

-MMP20chr11

102464326

-
intron-intronENST00000361236ENST00000544938TMEM123chr11

102319543

-MMP20chr11

102464326

-
In-frameENST00000398136ENST00000260228TMEM123chr11

102319543

-MMP20chr11

102464326

-
5CDS-intronENST00000398136ENST00000544938TMEM123chr11

102319543

-MMP20chr11

102464326

-
5UTR-3CDSENST00000532161ENST00000260228TMEM123chr11

102319543

-MMP20chr11

102464326

-
5UTR-intronENST00000532161ENST00000544938TMEM123chr11

102319543

-MMP20chr11

102464326

-
5UTR-3CDSENST00000525577ENST00000260228TMEM123chr11

102319543

-MMP20chr11

102464326

-
5UTR-intronENST00000525577ENST00000544938TMEM123chr11

102319543

-MMP20chr11

102464326

-
intron-3CDSENST00000361236ENST00000260228TMEM123chr11

102319543

-MMP20chr11

102480761

-
intron-intronENST00000361236ENST00000544938TMEM123chr11

102319543

-MMP20chr11

102480761

-
In-frameENST00000398136ENST00000260228TMEM123chr11

102319543

-MMP20chr11

102480761

-
5CDS-intronENST00000398136ENST00000544938TMEM123chr11

102319543

-MMP20chr11

102480761

-
5UTR-3CDSENST00000532161ENST00000260228TMEM123chr11

102319543

-MMP20chr11

102480761

-
5UTR-intronENST00000532161ENST00000544938TMEM123chr11

102319543

-MMP20chr11

102480761

-
5UTR-3CDSENST00000525577ENST00000260228TMEM123chr11

102319543

-MMP20chr11

102480761

-
5UTR-intronENST00000525577ENST00000544938TMEM123chr11

102319543

-MMP20chr11

102480761

-
intron-3CDSENST00000361236ENST00000260228TMEM123chr11

102319543

-MMP20chr11

102449873

-
intron-intronENST00000361236ENST00000544938TMEM123chr11

102319543

-MMP20chr11

102449873

-
Frame-shiftENST00000398136ENST00000260228TMEM123chr11

102319543

-MMP20chr11

102449873

-
5CDS-intronENST00000398136ENST00000544938TMEM123chr11

102319543

-MMP20chr11

102449873

-
5UTR-3CDSENST00000532161ENST00000260228TMEM123chr11

102319543

-MMP20chr11

102449873

-
5UTR-intronENST00000532161ENST00000544938TMEM123chr11

102319543

-MMP20chr11

102449873

-
5UTR-3CDSENST00000525577ENST00000260228TMEM123chr11

102319543

-MMP20chr11

102449873

-
5UTR-intronENST00000525577ENST00000544938TMEM123chr11

102319543

-MMP20chr11

102449873

-
intron-3CDSENST00000361236ENST00000260228TMEM123chr11

102319543

-MMP20chr11

102482634

-
intron-intronENST00000361236ENST00000544938TMEM123chr11

102319543

-MMP20chr11

102482634

-
Frame-shiftENST00000398136ENST00000260228TMEM123chr11

102319543

-MMP20chr11

102482634

-
5CDS-intronENST00000398136ENST00000544938TMEM123chr11

102319543

-MMP20chr11

102482634

-
5UTR-3CDSENST00000532161ENST00000260228TMEM123chr11

102319543

-MMP20chr11

102482634

-
5UTR-intronENST00000532161ENST00000544938TMEM123chr11

102319543

-MMP20chr11

102482634

-
5UTR-3CDSENST00000525577ENST00000260228TMEM123chr11

102319543

-MMP20chr11

102482634

-
5UTR-intronENST00000525577ENST00000544938TMEM123chr11

102319543

-MMP20chr11

102482634

-
intron-3CDSENST00000361236ENST00000260228TMEM123chr11

102319543

-MMP20chr11

102487790

-
intron-intronENST00000361236ENST00000544938TMEM123chr11

102319543

-MMP20chr11

102487790

-
Frame-shiftENST00000398136ENST00000260228TMEM123chr11

102319543

-MMP20chr11

102487790

-
5CDS-intronENST00000398136ENST00000544938TMEM123chr11

102319543

-MMP20chr11

102487790

-
5UTR-3CDSENST00000532161ENST00000260228TMEM123chr11

102319543

-MMP20chr11

102487790

-
5UTR-intronENST00000532161ENST00000544938TMEM123chr11

102319543

-MMP20chr11

102487790

-
5UTR-3CDSENST00000525577ENST00000260228TMEM123chr11

102319543

-MMP20chr11

102487790

-
5UTR-intronENST00000525577ENST00000544938TMEM123chr11

102319543

-MMP20chr11

102487790

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398136TMEM123chr11102319542-ENST00000260228MMP20chr11102464326-143157885939284
ENST00000398136TMEM123chr11102319543-ENST00000260228MMP20chr11102464326-143157885939284
ENST00000398136TMEM123chr11102319543-ENST00000260228MMP20chr11102480761-1998578851506473

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398136ENST00000260228TMEM123chr11102319542-MMP20chr11102464326-0.0027040160.99729604
ENST00000398136ENST00000260228TMEM123chr11102319543-MMP20chr11102464326-0.0027040160.99729604
ENST00000398136ENST00000260228TMEM123chr11102319543-MMP20chr11102480761-0.0004617140.9995383

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Fusion Genomic Features for TMEM123-MMP20


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM123-MMP20


check button Go to

FGviewer for the breakpoints of chr11:102319542-chr11:102464326

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMMP20chr11:102319542chr11:102464326ENST00000260228610391_439363.3333333333333484.0RepeatNote=Hemopexin 3
TgeneMMP20chr11:102319542chr11:102464326ENST00000260228610440_483363.3333333333333484.0RepeatNote=Hemopexin 4
TgeneMMP20chr11:102319543chr11:102464326ENST00000260228610391_439363.3333333333333484.0RepeatNote=Hemopexin 3
TgeneMMP20chr11:102319543chr11:102464326ENST00000260228610440_483363.3333333333333484.0RepeatNote=Hemopexin 4
TgeneMMP20chr11:102319543chr11:102480761ENST00000260228210293_343174.33333333333334484.0RepeatNote=Hemopexin 1
TgeneMMP20chr11:102319543chr11:102480761ENST00000260228210344_389174.33333333333334484.0RepeatNote=Hemopexin 2
TgeneMMP20chr11:102319543chr11:102480761ENST00000260228210391_439174.33333333333334484.0RepeatNote=Hemopexin 3
TgeneMMP20chr11:102319543chr11:102480761ENST00000260228210440_483174.33333333333334484.0RepeatNote=Hemopexin 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM123chr11:102319542chr11:102464326ENST00000361236-1452_1530190.0Compositional biasNote=Thr-rich
HgeneTMEM123chr11:102319542chr11:102464326ENST00000398136-2552_15352.333333333333336209.0Compositional biasNote=Thr-rich
HgeneTMEM123chr11:102319543chr11:102464326ENST00000361236-1452_1530190.0Compositional biasNote=Thr-rich
HgeneTMEM123chr11:102319543chr11:102464326ENST00000398136-2552_15352.333333333333336209.0Compositional biasNote=Thr-rich
HgeneTMEM123chr11:102319543chr11:102480761ENST00000361236-1452_1530190.0Compositional biasNote=Thr-rich
HgeneTMEM123chr11:102319543chr11:102480761ENST00000398136-2552_15352.333333333333336209.0Compositional biasNote=Thr-rich
HgeneTMEM123chr11:102319542chr11:102464326ENST00000361236-14188_2080190.0Topological domainCytoplasmic
HgeneTMEM123chr11:102319542chr11:102464326ENST00000361236-1427_1660190.0Topological domainExtracellular
HgeneTMEM123chr11:102319542chr11:102464326ENST00000398136-25188_20852.333333333333336209.0Topological domainCytoplasmic
HgeneTMEM123chr11:102319542chr11:102464326ENST00000398136-2527_16652.333333333333336209.0Topological domainExtracellular
HgeneTMEM123chr11:102319543chr11:102464326ENST00000361236-14188_2080190.0Topological domainCytoplasmic
HgeneTMEM123chr11:102319543chr11:102464326ENST00000361236-1427_1660190.0Topological domainExtracellular
HgeneTMEM123chr11:102319543chr11:102464326ENST00000398136-25188_20852.333333333333336209.0Topological domainCytoplasmic
HgeneTMEM123chr11:102319543chr11:102464326ENST00000398136-2527_16652.333333333333336209.0Topological domainExtracellular
HgeneTMEM123chr11:102319543chr11:102480761ENST00000361236-14188_2080190.0Topological domainCytoplasmic
HgeneTMEM123chr11:102319543chr11:102480761ENST00000361236-1427_1660190.0Topological domainExtracellular
HgeneTMEM123chr11:102319543chr11:102480761ENST00000398136-25188_20852.333333333333336209.0Topological domainCytoplasmic
HgeneTMEM123chr11:102319543chr11:102480761ENST00000398136-2527_16652.333333333333336209.0Topological domainExtracellular
HgeneTMEM123chr11:102319542chr11:102464326ENST00000361236-14167_1870190.0TransmembraneHelical
HgeneTMEM123chr11:102319542chr11:102464326ENST00000398136-25167_18752.333333333333336209.0TransmembraneHelical
HgeneTMEM123chr11:102319543chr11:102464326ENST00000361236-14167_1870190.0TransmembraneHelical
HgeneTMEM123chr11:102319543chr11:102464326ENST00000398136-25167_18752.333333333333336209.0TransmembraneHelical
HgeneTMEM123chr11:102319543chr11:102480761ENST00000361236-14167_1870190.0TransmembraneHelical
HgeneTMEM123chr11:102319543chr11:102480761ENST00000398136-25167_18752.333333333333336209.0TransmembraneHelical
TgeneMMP20chr11:102319542chr11:102464326ENST0000026022861098_105363.3333333333333484.0MotifCysteine switch
TgeneMMP20chr11:102319543chr11:102464326ENST0000026022861098_105363.3333333333333484.0MotifCysteine switch
TgeneMMP20chr11:102319543chr11:102480761ENST0000026022821098_105174.33333333333334484.0MotifCysteine switch
TgeneMMP20chr11:102319542chr11:102464326ENST00000260228610293_343363.3333333333333484.0RepeatNote=Hemopexin 1
TgeneMMP20chr11:102319542chr11:102464326ENST00000260228610344_389363.3333333333333484.0RepeatNote=Hemopexin 2
TgeneMMP20chr11:102319543chr11:102464326ENST00000260228610293_343363.3333333333333484.0RepeatNote=Hemopexin 1
TgeneMMP20chr11:102319543chr11:102464326ENST00000260228610344_389363.3333333333333484.0RepeatNote=Hemopexin 2


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Fusion Gene Sequence for TMEM123-MMP20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000398136_ENST00000260228_TCGA-CA-5254_TMEM123_chr11_102319542_-_MMP20_chr11_102464326_length(transcript)=1431nt_BP=578nt
AAAGGCTTCCTTCCGGGCACCGCGAAGCCAGCGTGCTCAGCATTCAGGGAGGCAGCGGCGCTCGCCTTCATCCAGGACAACAAAACTGCC
ATTTCCGAAGAGAAAGGAAACGGCTCGCGGTTTCTGGGGTTCCCAAGCGCGCGCCTGCGAGGGAGGCCGCGAGCCGAGTCGCCACGCCCA
GAACCCCGAGCCCGCCCCCGCGCCACCCAGCCCGGCCCCGCCGCCCCGGCTGCGCACGCGACGCCCCCTCCAGGCCCCGCTCCTGCGCCC
TATTTGGTCATTCGGGGGGCAAGCGGCGGGAGGGGAAACGTGCGCGGCCGAAGGGGAAGCGGAGCCGGCGCCGGCTGCGCAGAGGAGCCG
CTCTCGCCGCCGCCACCTCGGCTGGGAGCCCACGAGGCTGCCGCATCCTGCCCTCGGAACAATGGGACTCGGCGCGCGAGGTGCTTGGGC
CGCGCTGCTCCTGGGGACGCTGCAGGTGCTAGCGCTGCTGGGGGCCGCCCATGAAAGCGCAGCCATGGCGGCATCTGCAAACATAGAGAA
TTCTGGGCTTCCACACAACTCCAGTGCTAACTCAACAGGTCCCCACTACTGGATAACAAGAGGATTCCAAATGCAAGGTCCTCCTCGGAC
TATTTATGACTTTGGATTTCCAAGGCACGTGCAGCAAATAGATGCTGCTGTCTACCTCAGGGAGCCACAGAAGACCCTTTTCTTTGTGGG
AGATGAATACTACAGCTACGACGAAAGGAAAAGGAAAATGGAAAAAGACTATCCAAAGAATACTGAAGAAGAATTTTCAGGAGTAAATGG
CCAAATCGATGCTGCTGTAGAATTAAATGGCTACATTTACTTCTTTTCAGGACCAAAAACATACAAGTATGACACAGAGAAGGAAGATGT
GGTTAGTGTGGTGAAATCTAGTTCCTGGATTGGTTGCTAAATAGAAAAGCCTAGTCTTCTCAAGCAATGAGGATGACTACAAGCAGCCTC
TAACTGGATCTTAAGGACTAAAGCAGAATGTAGGAGAGGGATTCTTCCAAAGGCCTTCAAATCAAATTAGAATTCACTGAGAATAATAAT
ACTTCCAATTTTTTTCATAGTTGTATAATCAGAATTTCAATCCACATTAGAAAAGTTTTTATATGGGCAACTTTATGCGAAATCCAAATC
AACACAATGCACTCTGCAGTTAGACACCATTATTTTTTCTTACCTAATATACTGAAGCAGATTGATCCGTTTGATTTTTATTTCCAGGAG
GAAGACTAGTGGTGGATTCCATGACATATATTGTAATTCTTTTCATAGGAAATGTCATTACAGTATGAATTATAATTATTTACAAGCAAT

>In-frame_ENST00000398136_ENST00000260228_TCGA-CA-5254_TMEM123_chr11_102319542_-_MMP20_chr11_102464326_length(amino acids)=284AA_start in transcript=85_stop in transcript=939
MPFPKRKETARGFWGSQARACEGGREPSRHAQNPEPAPAPPSPAPPPRLRTRRPLQAPLLRPIWSFGGQAAGGETCAAEGEAEPAPAAQR
SRSRRRHLGWEPTRLPHPALGTMGLGARGAWAALLLGTLQVLALLGAAHESAAMAASANIENSGLPHNSSANSTGPHYWITRGFQMQGPP
RTIYDFGFPRHVQQIDAAVYLREPQKTLFFVGDEYYSYDERKRKMEKDYPKNTEEEFSGVNGQIDAAVELNGYIYFFSGPKTYKYDTEKE

--------------------------------------------------------------
>In-frame_ENST00000398136_ENST00000260228_TCGA-CA-5254-01A_TMEM123_chr11_102319543_-_MMP20_chr11_102464326_length(transcript)=1431nt_BP=578nt
AAAGGCTTCCTTCCGGGCACCGCGAAGCCAGCGTGCTCAGCATTCAGGGAGGCAGCGGCGCTCGCCTTCATCCAGGACAACAAAACTGCC
ATTTCCGAAGAGAAAGGAAACGGCTCGCGGTTTCTGGGGTTCCCAAGCGCGCGCCTGCGAGGGAGGCCGCGAGCCGAGTCGCCACGCCCA
GAACCCCGAGCCCGCCCCCGCGCCACCCAGCCCGGCCCCGCCGCCCCGGCTGCGCACGCGACGCCCCCTCCAGGCCCCGCTCCTGCGCCC
TATTTGGTCATTCGGGGGGCAAGCGGCGGGAGGGGAAACGTGCGCGGCCGAAGGGGAAGCGGAGCCGGCGCCGGCTGCGCAGAGGAGCCG
CTCTCGCCGCCGCCACCTCGGCTGGGAGCCCACGAGGCTGCCGCATCCTGCCCTCGGAACAATGGGACTCGGCGCGCGAGGTGCTTGGGC
CGCGCTGCTCCTGGGGACGCTGCAGGTGCTAGCGCTGCTGGGGGCCGCCCATGAAAGCGCAGCCATGGCGGCATCTGCAAACATAGAGAA
TTCTGGGCTTCCACACAACTCCAGTGCTAACTCAACAGGTCCCCACTACTGGATAACAAGAGGATTCCAAATGCAAGGTCCTCCTCGGAC
TATTTATGACTTTGGATTTCCAAGGCACGTGCAGCAAATAGATGCTGCTGTCTACCTCAGGGAGCCACAGAAGACCCTTTTCTTTGTGGG
AGATGAATACTACAGCTACGACGAAAGGAAAAGGAAAATGGAAAAAGACTATCCAAAGAATACTGAAGAAGAATTTTCAGGAGTAAATGG
CCAAATCGATGCTGCTGTAGAATTAAATGGCTACATTTACTTCTTTTCAGGACCAAAAACATACAAGTATGACACAGAGAAGGAAGATGT
GGTTAGTGTGGTGAAATCTAGTTCCTGGATTGGTTGCTAAATAGAAAAGCCTAGTCTTCTCAAGCAATGAGGATGACTACAAGCAGCCTC
TAACTGGATCTTAAGGACTAAAGCAGAATGTAGGAGAGGGATTCTTCCAAAGGCCTTCAAATCAAATTAGAATTCACTGAGAATAATAAT
ACTTCCAATTTTTTTCATAGTTGTATAATCAGAATTTCAATCCACATTAGAAAAGTTTTTATATGGGCAACTTTATGCGAAATCCAAATC
AACACAATGCACTCTGCAGTTAGACACCATTATTTTTTCTTACCTAATATACTGAAGCAGATTGATCCGTTTGATTTTTATTTCCAGGAG
GAAGACTAGTGGTGGATTCCATGACATATATTGTAATTCTTTTCATAGGAAATGTCATTACAGTATGAATTATAATTATTTACAAGCAAT

>In-frame_ENST00000398136_ENST00000260228_TCGA-CA-5254-01A_TMEM123_chr11_102319543_-_MMP20_chr11_102464326_length(amino acids)=284AA_start in transcript=85_stop in transcript=939
MPFPKRKETARGFWGSQARACEGGREPSRHAQNPEPAPAPPSPAPPPRLRTRRPLQAPLLRPIWSFGGQAAGGETCAAEGEAEPAPAAQR
SRSRRRHLGWEPTRLPHPALGTMGLGARGAWAALLLGTLQVLALLGAAHESAAMAASANIENSGLPHNSSANSTGPHYWITRGFQMQGPP
RTIYDFGFPRHVQQIDAAVYLREPQKTLFFVGDEYYSYDERKRKMEKDYPKNTEEEFSGVNGQIDAAVELNGYIYFFSGPKTYKYDTEKE

--------------------------------------------------------------
>In-frame_ENST00000398136_ENST00000260228_TCGA-35-4122-01A_TMEM123_chr11_102319543_-_MMP20_chr11_102480761_length(transcript)=1998nt_BP=578nt
AAAGGCTTCCTTCCGGGCACCGCGAAGCCAGCGTGCTCAGCATTCAGGGAGGCAGCGGCGCTCGCCTTCATCCAGGACAACAAAACTGCC
ATTTCCGAAGAGAAAGGAAACGGCTCGCGGTTTCTGGGGTTCCCAAGCGCGCGCCTGCGAGGGAGGCCGCGAGCCGAGTCGCCACGCCCA
GAACCCCGAGCCCGCCCCCGCGCCACCCAGCCCGGCCCCGCCGCCCCGGCTGCGCACGCGACGCCCCCTCCAGGCCCCGCTCCTGCGCCC
TATTTGGTCATTCGGGGGGCAAGCGGCGGGAGGGGAAACGTGCGCGGCCGAAGGGGAAGCGGAGCCGGCGCCGGCTGCGCAGAGGAGCCG
CTCTCGCCGCCGCCACCTCGGCTGGGAGCCCACGAGGCTGCCGCATCCTGCCCTCGGAACAATGGGACTCGGCGCGCGAGGTGCTTGGGC
CGCGCTGCTCCTGGGGACGCTGCAGGTGCTAGCGCTGCTGGGGGCCGCCCATGAAAGCGCAGCCATGGCGGCATCTGCAAACATAGAGAA
TTCTGGGCTTCCACACAACTCCAGTGCTAACTCAACAGATCACGGGGATTCCTATCCATTCGATGGGCCTCGGGGGACTCTAGCCCATGC
ATTTGCTCCTGGAGAAGGCCTGGGAGGAGATACACATTTCGACAATGCTGAGAAGTGGACTATGGGAACGAATGGTTTTAATTTGTTTAC
CGTTGCTGCTCATGAATTTGGCCATGCCCTGGGCCTGGCCCATTCCACAGACCCATCAGCACTGATGTACCCAACTTATAAGTACAAGAA
TCCCTATGGATTCCACCTCCCCAAAGATGATGTGAAAGGGATCCAGGCATTATACGGACCTCGGAAAGTATTCCTGGGGAAGCCCACTCT
GCCCCATGCCCCCCATCACAAGCCATCCATCCCTGACCTCTGTGACTCCAGCTCATCCTTTGACGCTGTGACAATGCTGGGGAAGGAGCT
CCTGCTCTTCAAGGACCGGATTTTCTGGAGACGGCAGGTTCACTTGCGGACAGGAATTCGGCCCAGCACTATTACCAGCTCCTTCCCCCA
GCTCATGTCCAATGTGGATGCAGCTTACGAAGTGGCTGAGAGGGGCACTGCTTACTTCTTCAAAGGTCCCCACTACTGGATAACAAGAGG
ATTCCAAATGCAAGGTCCTCCTCGGACTATTTATGACTTTGGATTTCCAAGGCACGTGCAGCAAATAGATGCTGCTGTCTACCTCAGGGA
GCCACAGAAGACCCTTTTCTTTGTGGGAGATGAATACTACAGCTACGACGAAAGGAAAAGGAAAATGGAAAAAGACTATCCAAAGAATAC
TGAAGAAGAATTTTCAGGAGTAAATGGCCAAATCGATGCTGCTGTAGAATTAAATGGCTACATTTACTTCTTTTCAGGACCAAAAACATA
CAAGTATGACACAGAGAAGGAAGATGTGGTTAGTGTGGTGAAATCTAGTTCCTGGATTGGTTGCTAAATAGAAAAGCCTAGTCTTCTCAA
GCAATGAGGATGACTACAAGCAGCCTCTAACTGGATCTTAAGGACTAAAGCAGAATGTAGGAGAGGGATTCTTCCAAAGGCCTTCAAATC
AAATTAGAATTCACTGAGAATAATAATACTTCCAATTTTTTTCATAGTTGTATAATCAGAATTTCAATCCACATTAGAAAAGTTTTTATA
TGGGCAACTTTATGCGAAATCCAAATCAACACAATGCACTCTGCAGTTAGACACCATTATTTTTTCTTACCTAATATACTGAAGCAGATT
GATCCGTTTGATTTTTATTTCCAGGAGGAAGACTAGTGGTGGATTCCATGACATATATTGTAATTCTTTTCATAGGAAATGTCATTACAG
TATGAATTATAATTATTTACAAGCAATGGCTTTTGTGGCCATCATTTGGCCATCATTTGTTATAATAAATATAAATTTCCCAATTTTTAC

>In-frame_ENST00000398136_ENST00000260228_TCGA-35-4122-01A_TMEM123_chr11_102319543_-_MMP20_chr11_102480761_length(amino acids)=473AA_start in transcript=85_stop in transcript=1506
MPFPKRKETARGFWGSQARACEGGREPSRHAQNPEPAPAPPSPAPPPRLRTRRPLQAPLLRPIWSFGGQAAGGETCAAEGEAEPAPAAQR
SRSRRRHLGWEPTRLPHPALGTMGLGARGAWAALLLGTLQVLALLGAAHESAAMAASANIENSGLPHNSSANSTDHGDSYPFDGPRGTLA
HAFAPGEGLGGDTHFDNAEKWTMGTNGFNLFTVAAHEFGHALGLAHSTDPSALMYPTYKYKNPYGFHLPKDDVKGIQALYGPRKVFLGKP
TLPHAPHHKPSIPDLCDSSSSFDAVTMLGKELLLFKDRIFWRRQVHLRTGIRPSTITSSFPQLMSNVDAAYEVAERGTAYFFKGPHYWIT
RGFQMQGPPRTIYDFGFPRHVQQIDAAVYLREPQKTLFFVGDEYYSYDERKRKMEKDYPKNTEEEFSGVNGQIDAAVELNGYIYFFSGPK

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Fusion Gene PPI Analysis for TMEM123-MMP20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMEM123-MMP20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMEM123-MMP20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMMP20C0399372Amelogenesis Imperfecta hypomaturation type1ORPHANET
TgeneMMP20C2675858Amelogenesis Imperfecta, Hypomaturation Type, Iia21CTD_human;GENOMICS_ENGLAND