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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TMEM135-CLMP (FusionGDB2 ID:91035)

Fusion Gene Summary for TMEM135-CLMP

Fusion gene summary

Fusion gene information	Fusion gene name: TMEM135-CLMP
	Fusion gene ID: 91035
		Hgene	Tgene
	Gene symbol	TMEM135	CLMP
	Gene ID	65084	79827
	Gene name	transmembrane protein 135	CXADR like membrane protein
	Synonyms	PMP52	ACAM\|ASAM\|CSBM\|CSBS
	Cytomap	11q14.2	11q24.1
	Type of gene	protein-coding	protein-coding
	Description	transmembrane protein 135peroxisomal membrane protein 52	CXADR-like membrane proteinCAR-like membrane proteinadipocyte-specific adhesion moleculecoxsackie- and adenovirus receptor-like membrane protein
	Modification date	20200313	20200313
	UniProtAcc	.	Q9H6B4
	Ensembl transtripts involved in fusion gene	ENST00000340353, ENST00000532959, ENST00000305494, ENST00000535167, ENST00000355734,	ENST00000448775, ENST00000530371,
Fusion gene scores	* DoF score	17 X 12 X 8=1632	2 X 2 X 2=8
	# samples	20	2
	** MAII score	log2(20/1632*10)=-3.02856915219677 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: TMEM135 [Title/Abstract] AND CLMP [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TMEM135(86802437)-CLMP(122955421), # samples:4
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TMEM135 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CLMP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A8-A06Z-01A	TMEM135	chr11	86802437	+	CLMP	chr11	122955421	-
ChimerDB4	BRCA	TCGA-A8-A06Z	TMEM135	chr11	86802437	+	CLMP	chr11	122955421	-
ChimerDB4	BRCA	TCGA-A8-A06Z-01A	TMEM135	chr11	86802437	+	CLMP	chr11	122955421	-
ChimerDB4	BRCA	TCGA-A8-A06Z-01A	TMEM135	chr11	86802437	-	CLMP	chr11	122955421	-

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Fusion Gene ORF analysis for TMEM135-CLMP

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000340353	ENST00000448775	TMEM135	chr11	86802437	+	CLMP	chr11	122955421	-
5CDS-intron	ENST00000340353	ENST00000530371	TMEM135	chr11	86802437	+	CLMP	chr11	122955421	-
intron-3CDS	ENST00000532959	ENST00000448775	TMEM135	chr11	86802437	+	CLMP	chr11	122955421	-
intron-intron	ENST00000532959	ENST00000530371	TMEM135	chr11	86802437	+	CLMP	chr11	122955421	-
In-frame	ENST00000305494	ENST00000448775	TMEM135	chr11	86802437	+	CLMP	chr11	122955421	-
5CDS-intron	ENST00000305494	ENST00000530371	TMEM135	chr11	86802437	+	CLMP	chr11	122955421	-
intron-3CDS	ENST00000535167	ENST00000448775	TMEM135	chr11	86802437	+	CLMP	chr11	122955421	-
intron-intron	ENST00000535167	ENST00000530371	TMEM135	chr11	86802437	+	CLMP	chr11	122955421	-
In-frame	ENST00000355734	ENST00000448775	TMEM135	chr11	86802437	+	CLMP	chr11	122955421	-
5CDS-intron	ENST00000355734	ENST00000530371	TMEM135	chr11	86802437	+	CLMP	chr11	122955421	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000340353	TMEM135	chr11	86802437	+	ENST00000448775	CLMP	chr11	122955421	-	2681	598	124	1533	469
ENST00000305494	TMEM135	chr11	86802437	+	ENST00000448775	CLMP	chr11	122955421	-	2518	435	27	1370	447
ENST00000355734	TMEM135	chr11	86802437	+	ENST00000448775	CLMP	chr11	122955421	-	2540	457	10	1392	460

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000340353	ENST00000448775	TMEM135	chr11	86802437	+	CLMP	chr11	122955421	-	0.007763933	0.9922361
ENST00000305494	ENST00000448775	TMEM135	chr11	86802437	+	CLMP	chr11	122955421	-	0.005592036	0.994408
ENST00000355734	ENST00000448775	TMEM135	chr11	86802437	+	CLMP	chr11	122955421	-	0.006342004	0.993658

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Fusion Genomic Features for TMEM135-CLMP

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM135-CLMP

Go to
FGviewer for the breakpoints of chr11:86802437-chr11:122955421
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CLMP Q9H6B4
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development. {ECO:0000269\|PubMed:14573622, ECO:0000269\|PubMed:15563274, ECO:0000269\|PubMed:22155368}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM135

chr11:86802437

chr11:122955421

ENST00000305494

68_88

132.0

459.0

Transmembrane

Helical

Hgene

TMEM135

chr11:86802437

chr11:122955421

ENST00000305494

96_116

132.0

459.0

Transmembrane

Helical

Hgene

TMEM135

chr11:86802437

chr11:122955421

ENST00000340353

68_88

132.0

437.0

Transmembrane

Helical

Hgene

TMEM135

chr11:86802437

chr11:122955421

ENST00000340353

96_116

132.0

437.0

Transmembrane

Helical

Tgene

CLMP

chr11:86802437

chr11:122955421

ENST00000448775

265_268

62.0

374.0

Compositional bias

Note=Poly-Glu

Tgene

CLMP

chr11:86802437

chr11:122955421

ENST00000448775

288_314

62.0

374.0

Compositional bias

Note=Ser-rich

Tgene

CLMP

chr11:86802437

chr11:122955421

ENST00000448775

135_224

62.0

374.0

Domain

Note=Ig-like C2-type 2

Tgene

CLMP

chr11:86802437

chr11:122955421

ENST00000448775

257_373

62.0

374.0

Topological domain

Cytoplasmic

Tgene

CLMP

chr11:86802437

chr11:122955421

ENST00000448775

236_256

62.0

374.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM135

chr11:86802437

chr11:122955421

ENST00000305494

149_169

132.0

459.0

Transmembrane

Helical

Hgene

TMEM135

chr11:86802437

chr11:122955421

ENST00000305494

298_318

132.0

459.0

Transmembrane

Helical

Hgene

TMEM135

chr11:86802437

chr11:122955421

ENST00000305494

331_351

132.0

459.0

Transmembrane

Helical

Hgene

TMEM135

chr11:86802437

chr11:122955421

ENST00000305494

380_400

132.0

459.0

Transmembrane

Helical

Hgene

TMEM135

chr11:86802437

chr11:122955421

ENST00000340353

149_169

132.0

437.0

Transmembrane

Helical

Hgene

TMEM135

chr11:86802437

chr11:122955421

ENST00000340353

298_318

132.0

437.0

Transmembrane

Helical

Hgene

TMEM135

chr11:86802437

chr11:122955421

ENST00000340353

331_351

132.0

437.0

Transmembrane

Helical

Hgene

TMEM135

chr11:86802437

chr11:122955421

ENST00000340353

380_400

132.0

437.0

Transmembrane

Helical

Tgene

CLMP

chr11:86802437

chr11:122955421

ENST00000448775

19_127

62.0

374.0

Domain

Note=Ig-like C2-type 1

Tgene

CLMP

chr11:86802437

chr11:122955421

ENST00000448775

19_235

62.0

374.0

Topological domain

Extracellular

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Fusion Gene Sequence for TMEM135-CLMP

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000340353_ENST00000448775_TCGA-A8-A06Z-01A_TMEM135_chr11_86802437_+_CLMP_chr11_122955421_length(transcript)=2681nt_BP=598nt
GTCCCGCCCCCTTGAGCTGCGATACGCCGAGCGCTCAACATCCGAGGACTTTGGCCCAGAGTAACCCCGCTCTCGTGACCTTTCCCCTCC
ATTCCGCACCTCCGAGTGCTGGCCGGGCGAGAGGCTGGCGGCTGGGCTCTCGCGCCCCTCCCTGCAGGGCTCAGGCTCTCCCCCTCCTGT
CTTCTCCGCGCTGTTCCTCGTCATGGCGGCCCTCAGCAAGTCCATCCCTCATAACTGCTATGAGATCGGCCACACTTGGCACCCTTCCTG
CCGGGTCTCCTTCCTGCAGATCACCGGGGGCGCCCTGGAGGAGTCCCTGAAGATCTATGCTCCTCTGTACTTGATTGCAGCAATTCTCCG
GAAACGGAAATTAGACTATTATTTACACAAACTACTCCCTGAGATCCTACAATCCGCTTCATTTCTAACTGCTAATGGGGCCTTGTATAT
GGCTTTCTTTTGCATTTTAAGGAAGATACTTGGAAAATTCTACTCATGGACTCCTGGCTTTGGTGCCGCTCTGCCAGCATCTTATGTGGC
CATTCTCATTGAAAGAAAAAGCAGGAGAGGGCTGCTCACAATTTATATGGCCAACTTGGTGATCACTTACTCCAGTCGTCATGTCTACAA
TAACTTGACTGAGGAACAGAAGGGCCGAGTGGCCTTTGCTTCCAATTTCCTGGCAGGAGATGCCTCCTTGCAGATTGAACCTCTGAAGCC
CAGTGATGAGGGCCGGTACACCTGTAAGGTTAAGAATTCAGGGCGCTACGTGTGGAGCCATGTCATCTTAAAAGTCTTAGTGAGACCATC
CAAGCCCAAGTGTGAGTTGGAAGGAGAGCTGACAGAAGGAAGTGACCTGACTTTGCAGTGTGAGTCATCCTCTGGCACAGAGCCCATTGT
GTATTACTGGCAGCGAATCCGAGAGAAAGAGGGAGAGGATGAACGTCTGCCTCCCAAATCTAGGATTGACTACAACCACCCTGGACGAGT
TCTGCTGCAGAATCTTACCATGTCCTACTCTGGACTGTACCAGTGCACAGCAGGCAACGAAGCTGGGAAGGAAAGCTGTGTGGTGCGAGT
AACTGTACAGTATGTACAAAGCATCGGCATGGTTGCAGGAGCAGTGACAGGCATAGTGGCTGGAGCCCTGCTGATTTTCCTCTTGGTGTG
GCTGCTAATCCGAAGGAAAGACAAAGAAAGATATGAGGAAGAAGAGAGACCTAATGAAATTCGAGAAGATGCTGAAGCTCCAAAAGCCCG
TCTTGTGAAACCCAGCTCCTCTTCCTCAGGCTCTCGGAGCTCACGCTCTGGTTCTTCCTCCACTCGCTCCACAGCAAATAGTGCCTCACG
CAGCCAGCGGACACTGTCAACTGACGCAGCACCCCAGCCAGGGCTGGCCACCCAGGCATACAGCCTAGTGGGGCCAGAGGTGAGAGGTTC
TGAACCAAAGAAAGTCCACCATGCTAATCTGACCAAAGCAGAAACCACACCCAGCATGATCCCCAGCCAGAGCAGAGCCTTCCAAACGGT
CTGAATTACAATGGACTTGACTCCCACGCTTTCCTAGGAGTCAGGGTCTTTGGACTCTTCTCGTCATTGGAGCTCAAGTCACCAGCCACA
CAACCAGATGAGAGGTCATCTAAGTAGCAGTGAGCATTGCACGGAACAGATTCAGATGAGCATTTTCCTTATACAATACCAAACAAGCAA
AAGGATGTAAGCTGATTCATCTGTAAAAAGGCATCTTATTGTGCCTTTAGACCAGAGTAAGGGAAAGCAGGAGTCCAAATCTATTTGTTG
ACCAGGACCTGTGGTGAGAAGGTTGGGGAAAGGTGAGGTGAATATACCTAAAACTTTTAATGTGGGATATTTTGTATCAGTGCTTTGATT
CACAATTTTCAAGAGGAAATGGGATGCTGTTTGTAAATTTTCTATGCATTTCTGCAAACTTATTGGATTATTAGTTATTCAGACAGTCAA
GCAGAACCCACAGCCTTATTACACCTGTCTACACCATGTACTGAGCTAACCACTTCTAAGAAACTCCAAAAAAGGAAACATGTGTCTTCT
ATTCTGACTTAACTTCATTTGTCATAAGGTTTGGATATTAATTTCAAGGGGAGTTGAAATAGTGGGAGATGGAGAAGAGTGAATGAGTTT
CTCCCACTCTATACTAATCTCACTATTTGTATTGAGCCCAAAATAACTATGAAAGGAGACAAAAATTTGTGACAAAGGATTGTGAAGAGC
TTTCCATCTTCATGATGTTATGAGGATTGTTGACAAACATTAGAAATATATAATGGAGCAATTGTGGATTTCCCCTCAAATCAGATGCCT
CTAAGGACTTTCCTGCTAGATATTTCTGGAAGGAGAAAATACAACATGTCATTTATCAACGTCCTTAGAAAGAATTCTTCTAGAGAAAAA
GGGATCTAGGAATGCTGAAAGATTACCCAACATACCATTATAGTCTCTTCTTTCTGAGAAAATGTGAAACCAGAATTGCAAGACTGGGTG
GACTAGAAAGGGAGATTAGATCAGTTTTCTCTTAATATGTCAAGGAAGGTAGCCGGGCATGGTGCCAGGCACCTGTAGGAAAATCCAGCA

>In-frame_ENST00000340353_ENST00000448775_TCGA-A8-A06Z-01A_TMEM135_chr11_86802437_+_CLMP_chr11_122955421_length(amino acids)=469AA_start in transcript=124_stop in transcript=1533
MAAGLSRPSLQGSGSPPPVFSALFLVMAALSKSIPHNCYEIGHTWHPSCRVSFLQITGGALEESLKIYAPLYLIAAILRKRKLDYYLHKL
LPEILQSASFLTANGALYMAFFCILRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMANLVITYSSRHVYNNLTEEQKGRVA
FASNFLAGDASLQIEPLKPSDEGRYTCKVKNSGRYVWSHVILKVLVRPSKPKCELEGELTEGSDLTLQCESSSGTEPIVYYWQRIREKEG
EDERLPPKSRIDYNHPGRVLLQNLTMSYSGLYQCTAGNEAGKESCVVRVTVQYVQSIGMVAGAVTGIVAGALLIFLLVWLLIRRKDKERY
EEEERPNEIREDAEAPKARLVKPSSSSSGSRSSRSGSSSTRSTANSASRSQRTLSTDAAPQPGLATQAYSLVGPEVRGSEPKKVHHANLT

--------------------------------------------------------------
>In-frame_ENST00000305494_ENST00000448775_TCGA-A8-A06Z-01A_TMEM135_chr11_86802437_+_CLMP_chr11_122955421_length(transcript)=2518nt_BP=435nt
GGCTCTCCCCCTCCTGTCTTCTCCGCGCTGTTCCTCGTCATGGCGGCCCTCAGCAAGTCCATCCCTCATAACTGCTATGAGATCGGCCAC
ACTTGGCACCCTTCCTGCCGGGTCTCCTTCCTGCAGATCACCGGGGGCGCCCTGGAGGAGTCCCTGAAGATCTATGCTCCTCTGTACTTG
ATTGCAGCAATTCTCCGGAAACGGAAATTAGACTATTATTTACACAAACTACTCCCTGAGATCCTACAATCCGCTTCATTTCTAACTGCT
AATGGGGCCTTGTATATGGCTTTCTTTTGCATTTTAAGGAAGATACTTGGAAAATTCTACTCATGGACTCCTGGCTTTGGTGCCGCTCTG
CCAGCATCTTATGTGGCCATTCTCATTGAAAGAAAAAGCAGGAGAGGGCTGCTCACAATTTATATGGCCAACTTGGTGATCACTTACTCC
AGTCGTCATGTCTACAATAACTTGACTGAGGAACAGAAGGGCCGAGTGGCCTTTGCTTCCAATTTCCTGGCAGGAGATGCCTCCTTGCAG
ATTGAACCTCTGAAGCCCAGTGATGAGGGCCGGTACACCTGTAAGGTTAAGAATTCAGGGCGCTACGTGTGGAGCCATGTCATCTTAAAA
GTCTTAGTGAGACCATCCAAGCCCAAGTGTGAGTTGGAAGGAGAGCTGACAGAAGGAAGTGACCTGACTTTGCAGTGTGAGTCATCCTCT
GGCACAGAGCCCATTGTGTATTACTGGCAGCGAATCCGAGAGAAAGAGGGAGAGGATGAACGTCTGCCTCCCAAATCTAGGATTGACTAC
AACCACCCTGGACGAGTTCTGCTGCAGAATCTTACCATGTCCTACTCTGGACTGTACCAGTGCACAGCAGGCAACGAAGCTGGGAAGGAA
AGCTGTGTGGTGCGAGTAACTGTACAGTATGTACAAAGCATCGGCATGGTTGCAGGAGCAGTGACAGGCATAGTGGCTGGAGCCCTGCTG
ATTTTCCTCTTGGTGTGGCTGCTAATCCGAAGGAAAGACAAAGAAAGATATGAGGAAGAAGAGAGACCTAATGAAATTCGAGAAGATGCT
GAAGCTCCAAAAGCCCGTCTTGTGAAACCCAGCTCCTCTTCCTCAGGCTCTCGGAGCTCACGCTCTGGTTCTTCCTCCACTCGCTCCACA
GCAAATAGTGCCTCACGCAGCCAGCGGACACTGTCAACTGACGCAGCACCCCAGCCAGGGCTGGCCACCCAGGCATACAGCCTAGTGGGG
CCAGAGGTGAGAGGTTCTGAACCAAAGAAAGTCCACCATGCTAATCTGACCAAAGCAGAAACCACACCCAGCATGATCCCCAGCCAGAGC
AGAGCCTTCCAAACGGTCTGAATTACAATGGACTTGACTCCCACGCTTTCCTAGGAGTCAGGGTCTTTGGACTCTTCTCGTCATTGGAGC
TCAAGTCACCAGCCACACAACCAGATGAGAGGTCATCTAAGTAGCAGTGAGCATTGCACGGAACAGATTCAGATGAGCATTTTCCTTATA
CAATACCAAACAAGCAAAAGGATGTAAGCTGATTCATCTGTAAAAAGGCATCTTATTGTGCCTTTAGACCAGAGTAAGGGAAAGCAGGAG
TCCAAATCTATTTGTTGACCAGGACCTGTGGTGAGAAGGTTGGGGAAAGGTGAGGTGAATATACCTAAAACTTTTAATGTGGGATATTTT
GTATCAGTGCTTTGATTCACAATTTTCAAGAGGAAATGGGATGCTGTTTGTAAATTTTCTATGCATTTCTGCAAACTTATTGGATTATTA
GTTATTCAGACAGTCAAGCAGAACCCACAGCCTTATTACACCTGTCTACACCATGTACTGAGCTAACCACTTCTAAGAAACTCCAAAAAA
GGAAACATGTGTCTTCTATTCTGACTTAACTTCATTTGTCATAAGGTTTGGATATTAATTTCAAGGGGAGTTGAAATAGTGGGAGATGGA
GAAGAGTGAATGAGTTTCTCCCACTCTATACTAATCTCACTATTTGTATTGAGCCCAAAATAACTATGAAAGGAGACAAAAATTTGTGAC
AAAGGATTGTGAAGAGCTTTCCATCTTCATGATGTTATGAGGATTGTTGACAAACATTAGAAATATATAATGGAGCAATTGTGGATTTCC
CCTCAAATCAGATGCCTCTAAGGACTTTCCTGCTAGATATTTCTGGAAGGAGAAAATACAACATGTCATTTATCAACGTCCTTAGAAAGA
ATTCTTCTAGAGAAAAAGGGATCTAGGAATGCTGAAAGATTACCCAACATACCATTATAGTCTCTTCTTTCTGAGAAAATGTGAAACCAG
AATTGCAAGACTGGGTGGACTAGAAAGGGAGATTAGATCAGTTTTCTCTTAATATGTCAAGGAAGGTAGCCGGGCATGGTGCCAGGCACC

>In-frame_ENST00000305494_ENST00000448775_TCGA-A8-A06Z-01A_TMEM135_chr11_86802437_+_CLMP_chr11_122955421_length(amino acids)=447AA_start in transcript=27_stop in transcript=1370
MFLVMAALSKSIPHNCYEIGHTWHPSCRVSFLQITGGALEESLKIYAPLYLIAAILRKRKLDYYLHKLLPEILQSASFLTANGALYMAFF
CILRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMANLVITYSSRHVYNNLTEEQKGRVAFASNFLAGDASLQIEPLKPSDE
GRYTCKVKNSGRYVWSHVILKVLVRPSKPKCELEGELTEGSDLTLQCESSSGTEPIVYYWQRIREKEGEDERLPPKSRIDYNHPGRVLLQ
NLTMSYSGLYQCTAGNEAGKESCVVRVTVQYVQSIGMVAGAVTGIVAGALLIFLLVWLLIRRKDKERYEEEERPNEIREDAEAPKARLVK

--------------------------------------------------------------
>In-frame_ENST00000355734_ENST00000448775_TCGA-A8-A06Z-01A_TMEM135_chr11_86802437_+_CLMP_chr11_122955421_length(transcript)=2540nt_BP=457nt
GCGCCCCTCCCTGCAGGGCTCAGGCTCTCCCCCTCCTGTCTTCTCCGCGCTGTTCCTCGTCATGGCGGCCCTCAGCAAGTCCATCCCTCA
TAACTGCTATGAGATCGGCCACACTTGGCACCCTTCCTGCCGGGTCTCCTTCCTGCAGATCACCGGGGGCGCCCTGGAGGAGTCCCTGAA
GATCTATGCTCCTCTGTACTTGATTGCAGCAATTCTCCGGAAACGGAAATTAGACTATTATTTACACAAACTACTCCCTGAGATCCTACA
ATCCGCTTCATTTCTAACTGCTAATGGGGCCTTGTATATGGCTTTCTTTTGCATTTTAAGGAAGATACTTGGAAAATTCTACTCATGGAC
TCCTGGCTTTGGTGCCGCTCTGCCAGCATCTTATGTGGCCATTCTCATTGAAAGAAAAAGCAGGAGAGGGCTGCTCACAATTTATATGGC
CAACTTGGTGATCACTTACTCCAGTCGTCATGTCTACAATAACTTGACTGAGGAACAGAAGGGCCGAGTGGCCTTTGCTTCCAATTTCCT
GGCAGGAGATGCCTCCTTGCAGATTGAACCTCTGAAGCCCAGTGATGAGGGCCGGTACACCTGTAAGGTTAAGAATTCAGGGCGCTACGT
GTGGAGCCATGTCATCTTAAAAGTCTTAGTGAGACCATCCAAGCCCAAGTGTGAGTTGGAAGGAGAGCTGACAGAAGGAAGTGACCTGAC
TTTGCAGTGTGAGTCATCCTCTGGCACAGAGCCCATTGTGTATTACTGGCAGCGAATCCGAGAGAAAGAGGGAGAGGATGAACGTCTGCC
TCCCAAATCTAGGATTGACTACAACCACCCTGGACGAGTTCTGCTGCAGAATCTTACCATGTCCTACTCTGGACTGTACCAGTGCACAGC
AGGCAACGAAGCTGGGAAGGAAAGCTGTGTGGTGCGAGTAACTGTACAGTATGTACAAAGCATCGGCATGGTTGCAGGAGCAGTGACAGG
CATAGTGGCTGGAGCCCTGCTGATTTTCCTCTTGGTGTGGCTGCTAATCCGAAGGAAAGACAAAGAAAGATATGAGGAAGAAGAGAGACC
TAATGAAATTCGAGAAGATGCTGAAGCTCCAAAAGCCCGTCTTGTGAAACCCAGCTCCTCTTCCTCAGGCTCTCGGAGCTCACGCTCTGG
TTCTTCCTCCACTCGCTCCACAGCAAATAGTGCCTCACGCAGCCAGCGGACACTGTCAACTGACGCAGCACCCCAGCCAGGGCTGGCCAC
CCAGGCATACAGCCTAGTGGGGCCAGAGGTGAGAGGTTCTGAACCAAAGAAAGTCCACCATGCTAATCTGACCAAAGCAGAAACCACACC
CAGCATGATCCCCAGCCAGAGCAGAGCCTTCCAAACGGTCTGAATTACAATGGACTTGACTCCCACGCTTTCCTAGGAGTCAGGGTCTTT
GGACTCTTCTCGTCATTGGAGCTCAAGTCACCAGCCACACAACCAGATGAGAGGTCATCTAAGTAGCAGTGAGCATTGCACGGAACAGAT
TCAGATGAGCATTTTCCTTATACAATACCAAACAAGCAAAAGGATGTAAGCTGATTCATCTGTAAAAAGGCATCTTATTGTGCCTTTAGA
CCAGAGTAAGGGAAAGCAGGAGTCCAAATCTATTTGTTGACCAGGACCTGTGGTGAGAAGGTTGGGGAAAGGTGAGGTGAATATACCTAA
AACTTTTAATGTGGGATATTTTGTATCAGTGCTTTGATTCACAATTTTCAAGAGGAAATGGGATGCTGTTTGTAAATTTTCTATGCATTT
CTGCAAACTTATTGGATTATTAGTTATTCAGACAGTCAAGCAGAACCCACAGCCTTATTACACCTGTCTACACCATGTACTGAGCTAACC
ACTTCTAAGAAACTCCAAAAAAGGAAACATGTGTCTTCTATTCTGACTTAACTTCATTTGTCATAAGGTTTGGATATTAATTTCAAGGGG
AGTTGAAATAGTGGGAGATGGAGAAGAGTGAATGAGTTTCTCCCACTCTATACTAATCTCACTATTTGTATTGAGCCCAAAATAACTATG
AAAGGAGACAAAAATTTGTGACAAAGGATTGTGAAGAGCTTTCCATCTTCATGATGTTATGAGGATTGTTGACAAACATTAGAAATATAT
AATGGAGCAATTGTGGATTTCCCCTCAAATCAGATGCCTCTAAGGACTTTCCTGCTAGATATTTCTGGAAGGAGAAAATACAACATGTCA
TTTATCAACGTCCTTAGAAAGAATTCTTCTAGAGAAAAAGGGATCTAGGAATGCTGAAAGATTACCCAACATACCATTATAGTCTCTTCT
TTCTGAGAAAATGTGAAACCAGAATTGCAAGACTGGGTGGACTAGAAAGGGAGATTAGATCAGTTTTCTCTTAATATGTCAAGGAAGGTA
GCCGGGCATGGTGCCAGGCACCTGTAGGAAAATCCAGCAGGTGGAGGTTGCAGTGAGCCAAGATTATGCCATTGCACTCCAGCCTGGGTG

>In-frame_ENST00000355734_ENST00000448775_TCGA-A8-A06Z-01A_TMEM135_chr11_86802437_+_CLMP_chr11_122955421_length(amino acids)=460AA_start in transcript=10_stop in transcript=1392
MQGSGSPPPVFSALFLVMAALSKSIPHNCYEIGHTWHPSCRVSFLQITGGALEESLKIYAPLYLIAAILRKRKLDYYLHKLLPEILQSAS
FLTANGALYMAFFCILRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMANLVITYSSRHVYNNLTEEQKGRVAFASNFLAGD
ASLQIEPLKPSDEGRYTCKVKNSGRYVWSHVILKVLVRPSKPKCELEGELTEGSDLTLQCESSSGTEPIVYYWQRIREKEGEDERLPPKS
RIDYNHPGRVLLQNLTMSYSGLYQCTAGNEAGKESCVVRVTVQYVQSIGMVAGAVTGIVAGALLIFLLVWLLIRRKDKERYEEEERPNEI
REDAEAPKARLVKPSSSSSGSRSSRSGSSSTRSTANSASRSQRTLSTDAAPQPGLATQAYSLVGPEVRGSEPKKVHHANLTKAETTPSMI

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Fusion Gene PPI Analysis for TMEM135-CLMP

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TMEM135-CLMP

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TMEM135-CLMP

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	TMEM135	C0007131	Non-Small Cell Lung Carcinoma	1	CTD_human
Hgene	TMEM135	C0017636	Glioblastoma	1	CTD_human
Hgene	TMEM135	C0020796	Profound Mental Retardation	1	CTD_human
Hgene	TMEM135	C0025363	Mental Retardation, Psychosocial	1	CTD_human
Hgene	TMEM135	C0334588	Giant Cell Glioblastoma	1	CTD_human
Hgene	TMEM135	C0917816	Mental deficiency	1	CTD_human
Hgene	TMEM135	C1621958	Glioblastoma Multiforme	1	CTD_human
Hgene	TMEM135	C3714756	Intellectual Disability	1	CTD_human
Tgene	CLMP	C0021847	Intestinal Pseudo-Obstruction	1	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT