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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMEM135-GRM5 (FusionGDB2 ID:91040)

Fusion Gene Summary for TMEM135-GRM5

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM135-GRM5
Fusion gene ID: 91040
HgeneTgene
Gene symbol

TMEM135

GRM5

Gene ID

65084

2915

Gene nametransmembrane protein 135glutamate metabotropic receptor 5
SynonymsPMP52GPRC1E|MGLUR5|PPP1R86|mGlu5
Cytomap

11q14.2

11q14.2-q14.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 135peroxisomal membrane protein 52metabotropic glutamate receptor 5glutamate receptor, metabotropic 5protein phosphatase 1, regulatory subunit 86
Modification date2020031320200329
UniProtAcc.

P41594

Ensembl transtripts involved in fusion geneENST00000340353, ENST00000532959, 
ENST00000305494, ENST00000535167, 
ENST00000355734, 		ENST00000455756, 
ENST00000418177, ENST00000305447, 
ENST00000305432, ENST00000393297, 
ENST00000393294, 
Fusion gene scores* DoF score17 X 12 X 8=16327 X 5 X 4=140
# samples 207
** MAII scorelog2(20/1632*10)=-3.02856915219677
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM135 [Title/Abstract] AND GRM5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMEM135(87006865)-GRM5(88242672), # samples:1
Anticipated loss of major functional domain due to fusion event.TMEM135-GRM5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
TMEM135-GRM5 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TMEM135 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GRM5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-7115-01ATMEM135chr11

87006865

-GRM5chr11

88242672

-


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Fusion Gene ORF analysis for TMEM135-GRM5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000340353ENST00000455756TMEM135chr11

87006865

-GRM5chr11

88242672

-
Frame-shiftENST00000340353ENST00000418177TMEM135chr11

87006865

-GRM5chr11

88242672

-
In-frameENST00000340353ENST00000305447TMEM135chr11

87006865

-GRM5chr11

88242672

-
In-frameENST00000340353ENST00000305432TMEM135chr11

87006865

-GRM5chr11

88242672

-
5CDS-intronENST00000340353ENST00000393297TMEM135chr11

87006865

-GRM5chr11

88242672

-
5CDS-intronENST00000340353ENST00000393294TMEM135chr11

87006865

-GRM5chr11

88242672

-
Frame-shiftENST00000532959ENST00000455756TMEM135chr11

87006865

-GRM5chr11

88242672

-
Frame-shiftENST00000532959ENST00000418177TMEM135chr11

87006865

-GRM5chr11

88242672

-
In-frameENST00000532959ENST00000305447TMEM135chr11

87006865

-GRM5chr11

88242672

-
In-frameENST00000532959ENST00000305432TMEM135chr11

87006865

-GRM5chr11

88242672

-
5CDS-intronENST00000532959ENST00000393297TMEM135chr11

87006865

-GRM5chr11

88242672

-
5CDS-intronENST00000532959ENST00000393294TMEM135chr11

87006865

-GRM5chr11

88242672

-
Frame-shiftENST00000305494ENST00000455756TMEM135chr11

87006865

-GRM5chr11

88242672

-
Frame-shiftENST00000305494ENST00000418177TMEM135chr11

87006865

-GRM5chr11

88242672

-
In-frameENST00000305494ENST00000305447TMEM135chr11

87006865

-GRM5chr11

88242672

-
In-frameENST00000305494ENST00000305432TMEM135chr11

87006865

-GRM5chr11

88242672

-
5CDS-intronENST00000305494ENST00000393297TMEM135chr11

87006865

-GRM5chr11

88242672

-
5CDS-intronENST00000305494ENST00000393294TMEM135chr11

87006865

-GRM5chr11

88242672

-
Frame-shiftENST00000535167ENST00000455756TMEM135chr11

87006865

-GRM5chr11

88242672

-
Frame-shiftENST00000535167ENST00000418177TMEM135chr11

87006865

-GRM5chr11

88242672

-
In-frameENST00000535167ENST00000305447TMEM135chr11

87006865

-GRM5chr11

88242672

-
In-frameENST00000535167ENST00000305432TMEM135chr11

87006865

-GRM5chr11

88242672

-
5CDS-intronENST00000535167ENST00000393297TMEM135chr11

87006865

-GRM5chr11

88242672

-
5CDS-intronENST00000535167ENST00000393294TMEM135chr11

87006865

-GRM5chr11

88242672

-
intron-3CDSENST00000355734ENST00000455756TMEM135chr11

87006865

-GRM5chr11

88242672

-
intron-3CDSENST00000355734ENST00000418177TMEM135chr11

87006865

-GRM5chr11

88242672

-
intron-3CDSENST00000355734ENST00000305447TMEM135chr11

87006865

-GRM5chr11

88242672

-
intron-3CDSENST00000355734ENST00000305432TMEM135chr11

87006865

-GRM5chr11

88242672

-
intron-intronENST00000355734ENST00000393297TMEM135chr11

87006865

-GRM5chr11

88242672

-
intron-intronENST00000355734ENST00000393294TMEM135chr11

87006865

-GRM5chr11

88242672

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000340353TMEM135chr1187006865-ENST00000305447GRM5chr1188242672-23826871241599491
ENST00000340353TMEM135chr1187006865-ENST00000305432GRM5chr1188242672-23826871241599491
ENST00000532959TMEM135chr1187006865-ENST00000305447GRM5chr1188242672-1992297251209394
ENST00000532959TMEM135chr1187006865-ENST00000305432GRM5chr1188242672-1992297251209394
ENST00000305494TMEM135chr1187006865-ENST00000305447GRM5chr1188242672-2285590271502491
ENST00000305494TMEM135chr1187006865-ENST00000305432GRM5chr1188242672-2285590271502491
ENST00000535167TMEM135chr1187006865-ENST00000305447GRM5chr1188242672-22185233891435348
ENST00000535167TMEM135chr1187006865-ENST00000305432GRM5chr1188242672-22185233891435348

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000340353ENST00000305447TMEM135chr1187006865-GRM5chr1188242672-0.0519536060.9480463
ENST00000340353ENST00000305432TMEM135chr1187006865-GRM5chr1188242672-0.0519536060.9480463
ENST00000532959ENST00000305447TMEM135chr1187006865-GRM5chr1188242672-0.0523847860.9476152
ENST00000532959ENST00000305432TMEM135chr1187006865-GRM5chr1188242672-0.0523847860.9476152
ENST00000305494ENST00000305447TMEM135chr1187006865-GRM5chr1188242672-0.046635410.95336455
ENST00000305494ENST00000305432TMEM135chr1187006865-GRM5chr1188242672-0.046635410.95336455
ENST00000535167ENST00000305447TMEM135chr1187006865-GRM5chr1188242672-0.0261431670.9738568
ENST00000535167ENST00000305432TMEM135chr1187006865-GRM5chr1188242672-0.0261431670.9738568

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Fusion Genomic Features for TMEM135-GRM5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM135-GRM5


check button Go to

FGviewer for the breakpoints of chr11:87006865-chr11:88242672

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GRM5

P41594

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. {ECO:0000269|PubMed:25042998, ECO:0000269|PubMed:7908515}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM135chr11:87006865chr11:88242672ENST00000305494-715149_169183.66666666666666459.0TransmembraneHelical
HgeneTMEM135chr11:87006865chr11:88242672ENST00000305494-71568_88183.66666666666666459.0TransmembraneHelical
HgeneTMEM135chr11:87006865chr11:88242672ENST00000305494-71596_116183.66666666666666459.0TransmembraneHelical
HgeneTMEM135chr11:87006865chr11:88242672ENST00000340353-61468_88161.66666666666666437.0TransmembraneHelical
HgeneTMEM135chr11:87006865chr11:88242672ENST00000340353-61496_116161.66666666666666437.0TransmembraneHelical
TgeneGRM5chr11:87006865chr11:88242672ENST0000039329709173_1750.0943.0RegionNote=Glutamate binding
TgeneGRM5chr11:87006865chr11:88242672ENST0000039329709805_8090.0943.0RegionNote=Allosteric effector binding
TgeneGRM5chr11:87006865chr11:88242672ENST000003932970922_5800.0943.0Topological domainExtracellular
TgeneGRM5chr11:87006865chr11:88242672ENST0000039329709604_6130.0943.0Topological domainCytoplasmic
TgeneGRM5chr11:87006865chr11:88242672ENST0000039329709637_6440.0943.0Topological domainExtracellular
TgeneGRM5chr11:87006865chr11:88242672ENST0000039329709668_6930.0943.0Topological domainCytoplasmic
TgeneGRM5chr11:87006865chr11:88242672ENST0000039329709715_7370.0943.0Topological domainExtracellular
TgeneGRM5chr11:87006865chr11:88242672ENST0000039329709760_7720.0943.0Topological domainCytoplasmic
TgeneGRM5chr11:87006865chr11:88242672ENST0000039329709796_7980.0943.0Topological domainExtracellular
TgeneGRM5chr11:87006865chr11:88242672ENST0000039329709821_12120.0943.0Topological domainCytoplasmic
TgeneGRM5chr11:87006865chr11:88242672ENST0000039329709581_6030.0943.0TransmembraneNote=Helical%3B Name%3D1
TgeneGRM5chr11:87006865chr11:88242672ENST0000039329709614_6360.0943.0TransmembraneNote=Helical%3B Name%3D2
TgeneGRM5chr11:87006865chr11:88242672ENST0000039329709645_6670.0943.0TransmembraneNote=Helical%3B Name%3D3
TgeneGRM5chr11:87006865chr11:88242672ENST0000039329709694_7140.0943.0TransmembraneNote=Helical%3B Name%3D4
TgeneGRM5chr11:87006865chr11:88242672ENST0000039329709738_7590.0943.0TransmembraneNote=Helical%3B Name%3D5
TgeneGRM5chr11:87006865chr11:88242672ENST0000039329709773_7950.0943.0TransmembraneNote=Helical%3B Name%3D6
TgeneGRM5chr11:87006865chr11:88242672ENST0000039329709799_8200.0943.0TransmembraneNote=Helical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM135chr11:87006865chr11:88242672ENST00000305494-715298_318183.66666666666666459.0TransmembraneHelical
HgeneTMEM135chr11:87006865chr11:88242672ENST00000305494-715331_351183.66666666666666459.0TransmembraneHelical
HgeneTMEM135chr11:87006865chr11:88242672ENST00000305494-715380_400183.66666666666666459.0TransmembraneHelical
HgeneTMEM135chr11:87006865chr11:88242672ENST00000340353-614149_169161.66666666666666437.0TransmembraneHelical
HgeneTMEM135chr11:87006865chr11:88242672ENST00000340353-614298_318161.66666666666666437.0TransmembraneHelical
HgeneTMEM135chr11:87006865chr11:88242672ENST00000340353-614331_351161.66666666666666437.0TransmembraneHelical
HgeneTMEM135chr11:87006865chr11:88242672ENST00000340353-614380_400161.66666666666666437.0TransmembraneHelical
TgeneGRM5chr11:87006865chr11:88242672ENST0000030543268173_175876.66666666666661181.0RegionNote=Glutamate binding
TgeneGRM5chr11:87006865chr11:88242672ENST0000030543268805_809876.66666666666661181.0RegionNote=Allosteric effector binding
TgeneGRM5chr11:87006865chr11:88242672ENST0000030544779173_175908.66666666666661213.0RegionNote=Glutamate binding
TgeneGRM5chr11:87006865chr11:88242672ENST0000030544779805_809908.66666666666661213.0RegionNote=Allosteric effector binding
TgeneGRM5chr11:87006865chr11:88242672ENST00000418177810173_175908.66666666666661213.0RegionNote=Glutamate binding
TgeneGRM5chr11:87006865chr11:88242672ENST00000418177810805_809908.66666666666661213.0RegionNote=Allosteric effector binding
TgeneGRM5chr11:87006865chr11:88242672ENST0000045575679173_175876.66666666666661181.0RegionNote=Glutamate binding
TgeneGRM5chr11:87006865chr11:88242672ENST0000045575679805_809876.66666666666661181.0RegionNote=Allosteric effector binding
TgeneGRM5chr11:87006865chr11:88242672ENST000003054326822_580876.66666666666661181.0Topological domainExtracellular
TgeneGRM5chr11:87006865chr11:88242672ENST0000030543268604_613876.66666666666661181.0Topological domainCytoplasmic
TgeneGRM5chr11:87006865chr11:88242672ENST0000030543268637_644876.66666666666661181.0Topological domainExtracellular
TgeneGRM5chr11:87006865chr11:88242672ENST0000030543268668_693876.66666666666661181.0Topological domainCytoplasmic
TgeneGRM5chr11:87006865chr11:88242672ENST0000030543268715_737876.66666666666661181.0Topological domainExtracellular
TgeneGRM5chr11:87006865chr11:88242672ENST0000030543268760_772876.66666666666661181.0Topological domainCytoplasmic
TgeneGRM5chr11:87006865chr11:88242672ENST0000030543268796_798876.66666666666661181.0Topological domainExtracellular
TgeneGRM5chr11:87006865chr11:88242672ENST0000030543268821_1212876.66666666666661181.0Topological domainCytoplasmic
TgeneGRM5chr11:87006865chr11:88242672ENST000003054477922_580908.66666666666661213.0Topological domainExtracellular
TgeneGRM5chr11:87006865chr11:88242672ENST0000030544779604_613908.66666666666661213.0Topological domainCytoplasmic
TgeneGRM5chr11:87006865chr11:88242672ENST0000030544779637_644908.66666666666661213.0Topological domainExtracellular
TgeneGRM5chr11:87006865chr11:88242672ENST0000030544779668_693908.66666666666661213.0Topological domainCytoplasmic
TgeneGRM5chr11:87006865chr11:88242672ENST0000030544779715_737908.66666666666661213.0Topological domainExtracellular
TgeneGRM5chr11:87006865chr11:88242672ENST0000030544779760_772908.66666666666661213.0Topological domainCytoplasmic
TgeneGRM5chr11:87006865chr11:88242672ENST0000030544779796_798908.66666666666661213.0Topological domainExtracellular
TgeneGRM5chr11:87006865chr11:88242672ENST0000030544779821_1212908.66666666666661213.0Topological domainCytoplasmic
TgeneGRM5chr11:87006865chr11:88242672ENST0000041817781022_580908.66666666666661213.0Topological domainExtracellular
TgeneGRM5chr11:87006865chr11:88242672ENST00000418177810604_613908.66666666666661213.0Topological domainCytoplasmic
TgeneGRM5chr11:87006865chr11:88242672ENST00000418177810637_644908.66666666666661213.0Topological domainExtracellular
TgeneGRM5chr11:87006865chr11:88242672ENST00000418177810668_693908.66666666666661213.0Topological domainCytoplasmic
TgeneGRM5chr11:87006865chr11:88242672ENST00000418177810715_737908.66666666666661213.0Topological domainExtracellular
TgeneGRM5chr11:87006865chr11:88242672ENST00000418177810760_772908.66666666666661213.0Topological domainCytoplasmic
TgeneGRM5chr11:87006865chr11:88242672ENST00000418177810796_798908.66666666666661213.0Topological domainExtracellular
TgeneGRM5chr11:87006865chr11:88242672ENST00000418177810821_1212908.66666666666661213.0Topological domainCytoplasmic
TgeneGRM5chr11:87006865chr11:88242672ENST000004557567922_580876.66666666666661181.0Topological domainExtracellular
TgeneGRM5chr11:87006865chr11:88242672ENST0000045575679604_613876.66666666666661181.0Topological domainCytoplasmic
TgeneGRM5chr11:87006865chr11:88242672ENST0000045575679637_644876.66666666666661181.0Topological domainExtracellular
TgeneGRM5chr11:87006865chr11:88242672ENST0000045575679668_693876.66666666666661181.0Topological domainCytoplasmic
TgeneGRM5chr11:87006865chr11:88242672ENST0000045575679715_737876.66666666666661181.0Topological domainExtracellular
TgeneGRM5chr11:87006865chr11:88242672ENST0000045575679760_772876.66666666666661181.0Topological domainCytoplasmic
TgeneGRM5chr11:87006865chr11:88242672ENST0000045575679796_798876.66666666666661181.0Topological domainExtracellular
TgeneGRM5chr11:87006865chr11:88242672ENST0000045575679821_1212876.66666666666661181.0Topological domainCytoplasmic
TgeneGRM5chr11:87006865chr11:88242672ENST0000030543268581_603876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D1
TgeneGRM5chr11:87006865chr11:88242672ENST0000030543268614_636876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D2
TgeneGRM5chr11:87006865chr11:88242672ENST0000030543268645_667876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D3
TgeneGRM5chr11:87006865chr11:88242672ENST0000030543268694_714876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D4
TgeneGRM5chr11:87006865chr11:88242672ENST0000030543268738_759876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D5
TgeneGRM5chr11:87006865chr11:88242672ENST0000030543268773_795876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D6
TgeneGRM5chr11:87006865chr11:88242672ENST0000030543268799_820876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D7
TgeneGRM5chr11:87006865chr11:88242672ENST0000030544779581_603908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D1
TgeneGRM5chr11:87006865chr11:88242672ENST0000030544779614_636908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D2
TgeneGRM5chr11:87006865chr11:88242672ENST0000030544779645_667908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D3
TgeneGRM5chr11:87006865chr11:88242672ENST0000030544779694_714908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D4
TgeneGRM5chr11:87006865chr11:88242672ENST0000030544779738_759908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D5
TgeneGRM5chr11:87006865chr11:88242672ENST0000030544779773_795908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D6
TgeneGRM5chr11:87006865chr11:88242672ENST0000030544779799_820908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D7
TgeneGRM5chr11:87006865chr11:88242672ENST00000418177810581_603908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D1
TgeneGRM5chr11:87006865chr11:88242672ENST00000418177810614_636908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D2
TgeneGRM5chr11:87006865chr11:88242672ENST00000418177810645_667908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D3
TgeneGRM5chr11:87006865chr11:88242672ENST00000418177810694_714908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D4
TgeneGRM5chr11:87006865chr11:88242672ENST00000418177810738_759908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D5
TgeneGRM5chr11:87006865chr11:88242672ENST00000418177810773_795908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D6
TgeneGRM5chr11:87006865chr11:88242672ENST00000418177810799_820908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D7
TgeneGRM5chr11:87006865chr11:88242672ENST0000045575679581_603876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D1
TgeneGRM5chr11:87006865chr11:88242672ENST0000045575679614_636876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D2
TgeneGRM5chr11:87006865chr11:88242672ENST0000045575679645_667876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D3
TgeneGRM5chr11:87006865chr11:88242672ENST0000045575679694_714876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D4
TgeneGRM5chr11:87006865chr11:88242672ENST0000045575679738_759876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D5
TgeneGRM5chr11:87006865chr11:88242672ENST0000045575679773_795876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D6
TgeneGRM5chr11:87006865chr11:88242672ENST0000045575679799_820876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D7


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Fusion Gene Sequence for TMEM135-GRM5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000340353_ENST00000305447_TCGA-EJ-7115-01A_TMEM135_chr11_87006865_-_GRM5_chr11_88242672_length(transcript)=2382nt_BP=687nt
GTCCCGCCCCCTTGAGCTGCGATACGCCGAGCGCTCAACATCCGAGGACTTTGGCCCAGAGTAACCCCGCTCTCGTGACCTTTCCCCTCC
ATTCCGCACCTCCGAGTGCTGGCCGGGCGAGAGGCTGGCGGCTGGGCTCTCGCGCCCCTCCCTGCAGGGCTCAGGCTCTCCCCCTCCTGT
CTTCTCCGCGCTGTTCCTCGTCATGGCGGCCCTCAGCAAGTCCATCCCTCATAACTGCTATGAGATCGGCCACACTTGGCACCCTTCCTG
CCGGGTCTCCTTCCTGCAGATCACCGGGGGCGCCCTGGAGGAGTCCCTGAAGATCTATGCTCCTCTGTACTTGATTGCAGCAATTCTCCG
GAAACGGAAATTAGACTATTATTTACACAAACTACTCCCTGAGATCCTACAATCCGCTTCATTTCTAACTGCTAATGGGGCCTTGTATAT
GGCTTTCTTTTGCATTTTAAGGAAGATACTTGGAAAATTCTACTCATGGACTCCTGGCTTTGGTGCCGCTCTGCCAGCATCTTATGTGGC
CATTCTCATTGAAAGAAAAAGCAGGAGAGGGCTGCTCACAATTTATATGGCCAACTTGGTCCTTTTGTTTTGCATCACAGCTGCCATGTA
CATGTTCTTTTTCAGGTGCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGTTCCAATGGAAAATCCGTCACGTGGGCCCAGAA
TGAGAAGAGCAGCCGGGGGCAGCACCTGTGGCAGCGCCTGTCCATCCACATCAACAAGAAAGAAAACCCCAACCAAACGGCCGTCATCAA
GCCCTTCCCCAAGAGCACGGAGAGCCGTGGCCTGGGCGCTGGCGCTGGCGCAGGCGGGAGCGCTGGGGGCGTGGGGGCCACGGGCGGTGC
GGGCTGCGCAGGCGCCGGCCCAGGCGGGCCCGAGTCCCCAGACGCCGGCCCCAAGGCGCTGTATGATGTGGCCGAGGCTGAGGAGCACTT
CCCGGCGCCCGCGCGGCCGCGCTCACCGTCGCCCATCAGCACGCTGAGCCACCGCGCGGGCTCGGCCAGCCGCACGGACGACGATGTGCC
GTCGCTGCACTCGGAGCCTGTGGCGCGCAGCAGCTCCTCGCAGGGCTCCCTCATGGAGCAGATCAGCAGTGTGGTCACCCGCTTCACGGC
CAACATCAGCGAGCTCAACTCCATGATGCTGTCCACCGCGGCCCCCAGCCCCGGCGTCGGCGCCCCGCTCTGCTCGTCCTACCTGATCCC
CAAAGAGATCCAGTTGCCCACGACCATGACGACCTTTGCCGAAATCCAGCCTCTGCCGGCCATCGAAGTCACGGGAGGCGCGCAGCCCGC
GGCAGGGGCGCAGGCGGCTGGGGACGCGGCCCGGGAGAGCCCCGCGGCCGGTCCCGAGGCTGCGGCCGCCAAGCCAGACCTGGAGGAGCT
GGTGGCTCTCACCCCGCCGTCCCCCTTCAGAGACTCGGTGGACTCGGGGAGCACAACCCCCAACTCGCCAGTGTCCGAGTCGGCCCTCTG
TATCCCGTCGTCTCCCAAATATGACACTCTTATCATAAGAGATTACACTCAGAGCTCCTCGTCGTTGTGAATGTCCCTGGAAAGCACGCC
GGCCTGCGCGTGCGGAGCGGAGCCCCCCGTGTTCACACACACACAATGGCAAGCATAGTCGCCTGGTTACGGCCCAGGGGGAAGATGCCA
AGGGCACCCCTTAATGGAAACACGAGATCAGTAGTGCTATCTCATGACAACCGACGAAGAAACCGACGACAAATCTTTTGGCAGATTTTC
TTCTAGTGGCCTTAGAAAACATGGGCTTTTAAGAAACACGGCTGATATCTTTGAGGGCTGACAAGGCGTCTCTTCAAACAGTTCCATACC
AAGTGCTTTGCTCTAGGGAAGCAGTGCGTGTGAAACAGCGTAACGGAGGGTGAAGAGCATAGTTAATAAGCAACTGTAAAAAGTTTTATT
TGTTTACTTTAATTCTTTTCCCAGAAGAGTCTTTGATTCACCAAACATGAATGTACATTTTCTAACAAACTCAAAATCTGGGACCAAAAC
ATCAACTTTTTTCTTTCTTTTTTCTTTCTTTTTGTTTTTTCTTTCCTGTAAAGACCTTGAAAAGCAGTAACTTGGGTCCAGTATTTACGG
AGGCGTTGTGAATGTGTCCCATGCATAACACACTACTGGATAGTGAGTGCTGCGCTAATGTACTACGTAGGGCTTCTACCAGAGATTTTC
CTCTCCAATTGGGTTGTGAAATACTCTTCCAAAAGCCTGCATCGGGGATTCCACCTACTTATTTCAGATTCACCTCCATTAACCAAGAAA

>In-frame_ENST00000340353_ENST00000305447_TCGA-EJ-7115-01A_TMEM135_chr11_87006865_-_GRM5_chr11_88242672_length(amino acids)=491AA_start in transcript=124_stop in transcript=1599
MAAGLSRPSLQGSGSPPPVFSALFLVMAALSKSIPHNCYEIGHTWHPSCRVSFLQITGGALEESLKIYAPLYLIAAILRKRKLDYYLHKL
LPEILQSASFLTANGALYMAFFCILRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMANLVLLFCITAAMYMFFFRCKDGLK
GFTFSALSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGGPE
SPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMMLS
TAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPFRD

--------------------------------------------------------------
>In-frame_ENST00000340353_ENST00000305432_TCGA-EJ-7115-01A_TMEM135_chr11_87006865_-_GRM5_chr11_88242672_length(transcript)=2382nt_BP=687nt
GTCCCGCCCCCTTGAGCTGCGATACGCCGAGCGCTCAACATCCGAGGACTTTGGCCCAGAGTAACCCCGCTCTCGTGACCTTTCCCCTCC
ATTCCGCACCTCCGAGTGCTGGCCGGGCGAGAGGCTGGCGGCTGGGCTCTCGCGCCCCTCCCTGCAGGGCTCAGGCTCTCCCCCTCCTGT
CTTCTCCGCGCTGTTCCTCGTCATGGCGGCCCTCAGCAAGTCCATCCCTCATAACTGCTATGAGATCGGCCACACTTGGCACCCTTCCTG
CCGGGTCTCCTTCCTGCAGATCACCGGGGGCGCCCTGGAGGAGTCCCTGAAGATCTATGCTCCTCTGTACTTGATTGCAGCAATTCTCCG
GAAACGGAAATTAGACTATTATTTACACAAACTACTCCCTGAGATCCTACAATCCGCTTCATTTCTAACTGCTAATGGGGCCTTGTATAT
GGCTTTCTTTTGCATTTTAAGGAAGATACTTGGAAAATTCTACTCATGGACTCCTGGCTTTGGTGCCGCTCTGCCAGCATCTTATGTGGC
CATTCTCATTGAAAGAAAAAGCAGGAGAGGGCTGCTCACAATTTATATGGCCAACTTGGTCCTTTTGTTTTGCATCACAGCTGCCATGTA
CATGTTCTTTTTCAGGTGCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGTTCCAATGGAAAATCCGTCACGTGGGCCCAGAA
TGAGAAGAGCAGCCGGGGGCAGCACCTGTGGCAGCGCCTGTCCATCCACATCAACAAGAAAGAAAACCCCAACCAAACGGCCGTCATCAA
GCCCTTCCCCAAGAGCACGGAGAGCCGTGGCCTGGGCGCTGGCGCTGGCGCAGGCGGGAGCGCTGGGGGCGTGGGGGCCACGGGCGGTGC
GGGCTGCGCAGGCGCCGGCCCAGGCGGGCCCGAGTCCCCAGACGCCGGCCCCAAGGCGCTGTATGATGTGGCCGAGGCTGAGGAGCACTT
CCCGGCGCCCGCGCGGCCGCGCTCACCGTCGCCCATCAGCACGCTGAGCCACCGCGCGGGCTCGGCCAGCCGCACGGACGACGATGTGCC
GTCGCTGCACTCGGAGCCTGTGGCGCGCAGCAGCTCCTCGCAGGGCTCCCTCATGGAGCAGATCAGCAGTGTGGTCACCCGCTTCACGGC
CAACATCAGCGAGCTCAACTCCATGATGCTGTCCACCGCGGCCCCCAGCCCCGGCGTCGGCGCCCCGCTCTGCTCGTCCTACCTGATCCC
CAAAGAGATCCAGTTGCCCACGACCATGACGACCTTTGCCGAAATCCAGCCTCTGCCGGCCATCGAAGTCACGGGAGGCGCGCAGCCCGC
GGCAGGGGCGCAGGCGGCTGGGGACGCGGCCCGGGAGAGCCCCGCGGCCGGTCCCGAGGCTGCGGCCGCCAAGCCAGACCTGGAGGAGCT
GGTGGCTCTCACCCCGCCGTCCCCCTTCAGAGACTCGGTGGACTCGGGGAGCACAACCCCCAACTCGCCAGTGTCCGAGTCGGCCCTCTG
TATCCCGTCGTCTCCCAAATATGACACTCTTATCATAAGAGATTACACTCAGAGCTCCTCGTCGTTGTGAATGTCCCTGGAAAGCACGCC
GGCCTGCGCGTGCGGAGCGGAGCCCCCCGTGTTCACACACACACAATGGCAAGCATAGTCGCCTGGTTACGGCCCAGGGGGAAGATGCCA
AGGGCACCCCTTAATGGAAACACGAGATCAGTAGTGCTATCTCATGACAACCGACGAAGAAACCGACGACAAATCTTTTGGCAGATTTTC
TTCTAGTGGCCTTAGAAAACATGGGCTTTTAAGAAACACGGCTGATATCTTTGAGGGCTGACAAGGCGTCTCTTCAAACAGTTCCATACC
AAGTGCTTTGCTCTAGGGAAGCAGTGCGTGTGAAACAGCGTAACGGAGGGTGAAGAGCATAGTTAATAAGCAACTGTAAAAAGTTTTATT
TGTTTACTTTAATTCTTTTCCCAGAAGAGTCTTTGATTCACCAAACATGAATGTACATTTTCTAACAAACTCAAAATCTGGGACCAAAAC
ATCAACTTTTTTCTTTCTTTTTTCTTTCTTTTTGTTTTTTCTTTCCTGTAAAGACCTTGAAAAGCAGTAACTTGGGTCCAGTATTTACGG
AGGCGTTGTGAATGTGTCCCATGCATAACACACTACTGGATAGTGAGTGCTGCGCTAATGTACTACGTAGGGCTTCTACCAGAGATTTTC
CTCTCCAATTGGGTTGTGAAATACTCTTCCAAAAGCCTGCATCGGGGATTCCACCTACTTATTTCAGATTCACCTCCATTAACCAAGAAA

>In-frame_ENST00000340353_ENST00000305432_TCGA-EJ-7115-01A_TMEM135_chr11_87006865_-_GRM5_chr11_88242672_length(amino acids)=491AA_start in transcript=124_stop in transcript=1599
MAAGLSRPSLQGSGSPPPVFSALFLVMAALSKSIPHNCYEIGHTWHPSCRVSFLQITGGALEESLKIYAPLYLIAAILRKRKLDYYLHKL
LPEILQSASFLTANGALYMAFFCILRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMANLVLLFCITAAMYMFFFRCKDGLK
GFTFSALSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGGPE
SPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMMLS
TAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPFRD

--------------------------------------------------------------
>In-frame_ENST00000532959_ENST00000305447_TCGA-EJ-7115-01A_TMEM135_chr11_87006865_-_GRM5_chr11_88242672_length(transcript)=1992nt_BP=297nt
TGCTGGCCGGGCGAGAGGCTGGCGGCTGGGCTCTCGCGCCCCTCCCTGCAGGGCTCAGGCTCTCCCCCTCCTGTCTTCTCCGCGCTGTTC
CTCGTCATGGCGGCCCTCAGCAAGTCCATCCCTCATAACTGCTATGAGATCGGCCACAGAAACACTATTCAGAATGGGTGTAGCAAGAGG
AACCATCACAACATTAAGAAATGGAGAAGTCCTTTTGTTTTGCATCACAGCTGCCATGTACATGTTCTTTTTCAGGTGCAAGGATGGCTT
GAAAGGATTTACATTTTCTGCACTTAGTTCCAATGGAAAATCCGTCACGTGGGCCCAGAATGAGAAGAGCAGCCGGGGGCAGCACCTGTG
GCAGCGCCTGTCCATCCACATCAACAAGAAAGAAAACCCCAACCAAACGGCCGTCATCAAGCCCTTCCCCAAGAGCACGGAGAGCCGTGG
CCTGGGCGCTGGCGCTGGCGCAGGCGGGAGCGCTGGGGGCGTGGGGGCCACGGGCGGTGCGGGCTGCGCAGGCGCCGGCCCAGGCGGGCC
CGAGTCCCCAGACGCCGGCCCCAAGGCGCTGTATGATGTGGCCGAGGCTGAGGAGCACTTCCCGGCGCCCGCGCGGCCGCGCTCACCGTC
GCCCATCAGCACGCTGAGCCACCGCGCGGGCTCGGCCAGCCGCACGGACGACGATGTGCCGTCGCTGCACTCGGAGCCTGTGGCGCGCAG
CAGCTCCTCGCAGGGCTCCCTCATGGAGCAGATCAGCAGTGTGGTCACCCGCTTCACGGCCAACATCAGCGAGCTCAACTCCATGATGCT
GTCCACCGCGGCCCCCAGCCCCGGCGTCGGCGCCCCGCTCTGCTCGTCCTACCTGATCCCCAAAGAGATCCAGTTGCCCACGACCATGAC
GACCTTTGCCGAAATCCAGCCTCTGCCGGCCATCGAAGTCACGGGAGGCGCGCAGCCCGCGGCAGGGGCGCAGGCGGCTGGGGACGCGGC
CCGGGAGAGCCCCGCGGCCGGTCCCGAGGCTGCGGCCGCCAAGCCAGACCTGGAGGAGCTGGTGGCTCTCACCCCGCCGTCCCCCTTCAG
AGACTCGGTGGACTCGGGGAGCACAACCCCCAACTCGCCAGTGTCCGAGTCGGCCCTCTGTATCCCGTCGTCTCCCAAATATGACACTCT
TATCATAAGAGATTACACTCAGAGCTCCTCGTCGTTGTGAATGTCCCTGGAAAGCACGCCGGCCTGCGCGTGCGGAGCGGAGCCCCCCGT
GTTCACACACACACAATGGCAAGCATAGTCGCCTGGTTACGGCCCAGGGGGAAGATGCCAAGGGCACCCCTTAATGGAAACACGAGATCA
GTAGTGCTATCTCATGACAACCGACGAAGAAACCGACGACAAATCTTTTGGCAGATTTTCTTCTAGTGGCCTTAGAAAACATGGGCTTTT
AAGAAACACGGCTGATATCTTTGAGGGCTGACAAGGCGTCTCTTCAAACAGTTCCATACCAAGTGCTTTGCTCTAGGGAAGCAGTGCGTG
TGAAACAGCGTAACGGAGGGTGAAGAGCATAGTTAATAAGCAACTGTAAAAAGTTTTATTTGTTTACTTTAATTCTTTTCCCAGAAGAGT
CTTTGATTCACCAAACATGAATGTACATTTTCTAACAAACTCAAAATCTGGGACCAAAACATCAACTTTTTTCTTTCTTTTTTCTTTCTT
TTTGTTTTTTCTTTCCTGTAAAGACCTTGAAAAGCAGTAACTTGGGTCCAGTATTTACGGAGGCGTTGTGAATGTGTCCCATGCATAACA
CACTACTGGATAGTGAGTGCTGCGCTAATGTACTACGTAGGGCTTCTACCAGAGATTTTCCTCTCCAATTGGGTTGTGAAATACTCTTCC
AAAAGCCTGCATCGGGGATTCCACCTACTTATTTCAGATTCACCTCCATTAACCAAGAAAACCAGTGGAAGATTTCTTGACTATTTCACC

>In-frame_ENST00000532959_ENST00000305447_TCGA-EJ-7115-01A_TMEM135_chr11_87006865_-_GRM5_chr11_88242672_length(amino acids)=394AA_start in transcript=25_stop in transcript=1209
MGSRAPPCRAQALPLLSSPRCSSSWRPSASPSLITAMRSATETLFRMGVARGTITTLRNGEVLLFCITAAMYMFFFRCKDGLKGFTFSAL
SSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGGPESPDAGPK
ALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAAPSPG
VGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPFRDSVDSGST

--------------------------------------------------------------
>In-frame_ENST00000532959_ENST00000305432_TCGA-EJ-7115-01A_TMEM135_chr11_87006865_-_GRM5_chr11_88242672_length(transcript)=1992nt_BP=297nt
TGCTGGCCGGGCGAGAGGCTGGCGGCTGGGCTCTCGCGCCCCTCCCTGCAGGGCTCAGGCTCTCCCCCTCCTGTCTTCTCCGCGCTGTTC
CTCGTCATGGCGGCCCTCAGCAAGTCCATCCCTCATAACTGCTATGAGATCGGCCACAGAAACACTATTCAGAATGGGTGTAGCAAGAGG
AACCATCACAACATTAAGAAATGGAGAAGTCCTTTTGTTTTGCATCACAGCTGCCATGTACATGTTCTTTTTCAGGTGCAAGGATGGCTT
GAAAGGATTTACATTTTCTGCACTTAGTTCCAATGGAAAATCCGTCACGTGGGCCCAGAATGAGAAGAGCAGCCGGGGGCAGCACCTGTG
GCAGCGCCTGTCCATCCACATCAACAAGAAAGAAAACCCCAACCAAACGGCCGTCATCAAGCCCTTCCCCAAGAGCACGGAGAGCCGTGG
CCTGGGCGCTGGCGCTGGCGCAGGCGGGAGCGCTGGGGGCGTGGGGGCCACGGGCGGTGCGGGCTGCGCAGGCGCCGGCCCAGGCGGGCC
CGAGTCCCCAGACGCCGGCCCCAAGGCGCTGTATGATGTGGCCGAGGCTGAGGAGCACTTCCCGGCGCCCGCGCGGCCGCGCTCACCGTC
GCCCATCAGCACGCTGAGCCACCGCGCGGGCTCGGCCAGCCGCACGGACGACGATGTGCCGTCGCTGCACTCGGAGCCTGTGGCGCGCAG
CAGCTCCTCGCAGGGCTCCCTCATGGAGCAGATCAGCAGTGTGGTCACCCGCTTCACGGCCAACATCAGCGAGCTCAACTCCATGATGCT
GTCCACCGCGGCCCCCAGCCCCGGCGTCGGCGCCCCGCTCTGCTCGTCCTACCTGATCCCCAAAGAGATCCAGTTGCCCACGACCATGAC
GACCTTTGCCGAAATCCAGCCTCTGCCGGCCATCGAAGTCACGGGAGGCGCGCAGCCCGCGGCAGGGGCGCAGGCGGCTGGGGACGCGGC
CCGGGAGAGCCCCGCGGCCGGTCCCGAGGCTGCGGCCGCCAAGCCAGACCTGGAGGAGCTGGTGGCTCTCACCCCGCCGTCCCCCTTCAG
AGACTCGGTGGACTCGGGGAGCACAACCCCCAACTCGCCAGTGTCCGAGTCGGCCCTCTGTATCCCGTCGTCTCCCAAATATGACACTCT
TATCATAAGAGATTACACTCAGAGCTCCTCGTCGTTGTGAATGTCCCTGGAAAGCACGCCGGCCTGCGCGTGCGGAGCGGAGCCCCCCGT
GTTCACACACACACAATGGCAAGCATAGTCGCCTGGTTACGGCCCAGGGGGAAGATGCCAAGGGCACCCCTTAATGGAAACACGAGATCA
GTAGTGCTATCTCATGACAACCGACGAAGAAACCGACGACAAATCTTTTGGCAGATTTTCTTCTAGTGGCCTTAGAAAACATGGGCTTTT
AAGAAACACGGCTGATATCTTTGAGGGCTGACAAGGCGTCTCTTCAAACAGTTCCATACCAAGTGCTTTGCTCTAGGGAAGCAGTGCGTG
TGAAACAGCGTAACGGAGGGTGAAGAGCATAGTTAATAAGCAACTGTAAAAAGTTTTATTTGTTTACTTTAATTCTTTTCCCAGAAGAGT
CTTTGATTCACCAAACATGAATGTACATTTTCTAACAAACTCAAAATCTGGGACCAAAACATCAACTTTTTTCTTTCTTTTTTCTTTCTT
TTTGTTTTTTCTTTCCTGTAAAGACCTTGAAAAGCAGTAACTTGGGTCCAGTATTTACGGAGGCGTTGTGAATGTGTCCCATGCATAACA
CACTACTGGATAGTGAGTGCTGCGCTAATGTACTACGTAGGGCTTCTACCAGAGATTTTCCTCTCCAATTGGGTTGTGAAATACTCTTCC
AAAAGCCTGCATCGGGGATTCCACCTACTTATTTCAGATTCACCTCCATTAACCAAGAAAACCAGTGGAAGATTTCTTGACTATTTCACC

>In-frame_ENST00000532959_ENST00000305432_TCGA-EJ-7115-01A_TMEM135_chr11_87006865_-_GRM5_chr11_88242672_length(amino acids)=394AA_start in transcript=25_stop in transcript=1209
MGSRAPPCRAQALPLLSSPRCSSSWRPSASPSLITAMRSATETLFRMGVARGTITTLRNGEVLLFCITAAMYMFFFRCKDGLKGFTFSAL
SSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGGPESPDAGPK
ALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAAPSPG
VGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPFRDSVDSGST

--------------------------------------------------------------
>In-frame_ENST00000305494_ENST00000305447_TCGA-EJ-7115-01A_TMEM135_chr11_87006865_-_GRM5_chr11_88242672_length(transcript)=2285nt_BP=590nt
GGCTCTCCCCCTCCTGTCTTCTCCGCGCTGTTCCTCGTCATGGCGGCCCTCAGCAAGTCCATCCCTCATAACTGCTATGAGATCGGCCAC
ACTTGGCACCCTTCCTGCCGGGTCTCCTTCCTGCAGATCACCGGGGGCGCCCTGGAGGAGTCCCTGAAGATCTATGCTCCTCTGTACTTG
ATTGCAGCAATTCTCCGGAAACGGAAATTAGACTATTATTTACACAAACTACTCCCTGAGATCCTACAATCCGCTTCATTTCTAACTGCT
AATGGGGCCTTGTATATGGCTTTCTTTTGCATTTTAAGGAAGATACTTGGAAAATTCTACTCATGGACTCCTGGCTTTGGTGCCGCTCTG
CCAGCATCTTATGTGGCCATTCTCATTGAAAGAAAAAGCAGGAGAGGGCTGCTCACAATTTATATGGCCAACTTGGCCACAGAAACACTA
TTCAGAATGGGTGTAGCAAGAGGAACCATCACAACATTAAGAAATGGAGAAGTCCTTTTGTTTTGCATCACAGCTGCCATGTACATGTTC
TTTTTCAGGTGCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGTTCCAATGGAAAATCCGTCACGTGGGCCCAGAATGAGAAG
AGCAGCCGGGGGCAGCACCTGTGGCAGCGCCTGTCCATCCACATCAACAAGAAAGAAAACCCCAACCAAACGGCCGTCATCAAGCCCTTC
CCCAAGAGCACGGAGAGCCGTGGCCTGGGCGCTGGCGCTGGCGCAGGCGGGAGCGCTGGGGGCGTGGGGGCCACGGGCGGTGCGGGCTGC
GCAGGCGCCGGCCCAGGCGGGCCCGAGTCCCCAGACGCCGGCCCCAAGGCGCTGTATGATGTGGCCGAGGCTGAGGAGCACTTCCCGGCG
CCCGCGCGGCCGCGCTCACCGTCGCCCATCAGCACGCTGAGCCACCGCGCGGGCTCGGCCAGCCGCACGGACGACGATGTGCCGTCGCTG
CACTCGGAGCCTGTGGCGCGCAGCAGCTCCTCGCAGGGCTCCCTCATGGAGCAGATCAGCAGTGTGGTCACCCGCTTCACGGCCAACATC
AGCGAGCTCAACTCCATGATGCTGTCCACCGCGGCCCCCAGCCCCGGCGTCGGCGCCCCGCTCTGCTCGTCCTACCTGATCCCCAAAGAG
ATCCAGTTGCCCACGACCATGACGACCTTTGCCGAAATCCAGCCTCTGCCGGCCATCGAAGTCACGGGAGGCGCGCAGCCCGCGGCAGGG
GCGCAGGCGGCTGGGGACGCGGCCCGGGAGAGCCCCGCGGCCGGTCCCGAGGCTGCGGCCGCCAAGCCAGACCTGGAGGAGCTGGTGGCT
CTCACCCCGCCGTCCCCCTTCAGAGACTCGGTGGACTCGGGGAGCACAACCCCCAACTCGCCAGTGTCCGAGTCGGCCCTCTGTATCCCG
TCGTCTCCCAAATATGACACTCTTATCATAAGAGATTACACTCAGAGCTCCTCGTCGTTGTGAATGTCCCTGGAAAGCACGCCGGCCTGC
GCGTGCGGAGCGGAGCCCCCCGTGTTCACACACACACAATGGCAAGCATAGTCGCCTGGTTACGGCCCAGGGGGAAGATGCCAAGGGCAC
CCCTTAATGGAAACACGAGATCAGTAGTGCTATCTCATGACAACCGACGAAGAAACCGACGACAAATCTTTTGGCAGATTTTCTTCTAGT
GGCCTTAGAAAACATGGGCTTTTAAGAAACACGGCTGATATCTTTGAGGGCTGACAAGGCGTCTCTTCAAACAGTTCCATACCAAGTGCT
TTGCTCTAGGGAAGCAGTGCGTGTGAAACAGCGTAACGGAGGGTGAAGAGCATAGTTAATAAGCAACTGTAAAAAGTTTTATTTGTTTAC
TTTAATTCTTTTCCCAGAAGAGTCTTTGATTCACCAAACATGAATGTACATTTTCTAACAAACTCAAAATCTGGGACCAAAACATCAACT
TTTTTCTTTCTTTTTTCTTTCTTTTTGTTTTTTCTTTCCTGTAAAGACCTTGAAAAGCAGTAACTTGGGTCCAGTATTTACGGAGGCGTT
GTGAATGTGTCCCATGCATAACACACTACTGGATAGTGAGTGCTGCGCTAATGTACTACGTAGGGCTTCTACCAGAGATTTTCCTCTCCA
ATTGGGTTGTGAAATACTCTTCCAAAAGCCTGCATCGGGGATTCCACCTACTTATTTCAGATTCACCTCCATTAACCAAGAAAACCAGTG

>In-frame_ENST00000305494_ENST00000305447_TCGA-EJ-7115-01A_TMEM135_chr11_87006865_-_GRM5_chr11_88242672_length(amino acids)=491AA_start in transcript=27_stop in transcript=1502
MFLVMAALSKSIPHNCYEIGHTWHPSCRVSFLQITGGALEESLKIYAPLYLIAAILRKRKLDYYLHKLLPEILQSASFLTANGALYMAFF
CILRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMANLATETLFRMGVARGTITTLRNGEVLLFCITAAMYMFFFRCKDGLK
GFTFSALSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGGPE
SPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMMLS
TAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPFRD

--------------------------------------------------------------
>In-frame_ENST00000305494_ENST00000305432_TCGA-EJ-7115-01A_TMEM135_chr11_87006865_-_GRM5_chr11_88242672_length(transcript)=2285nt_BP=590nt
GGCTCTCCCCCTCCTGTCTTCTCCGCGCTGTTCCTCGTCATGGCGGCCCTCAGCAAGTCCATCCCTCATAACTGCTATGAGATCGGCCAC
ACTTGGCACCCTTCCTGCCGGGTCTCCTTCCTGCAGATCACCGGGGGCGCCCTGGAGGAGTCCCTGAAGATCTATGCTCCTCTGTACTTG
ATTGCAGCAATTCTCCGGAAACGGAAATTAGACTATTATTTACACAAACTACTCCCTGAGATCCTACAATCCGCTTCATTTCTAACTGCT
AATGGGGCCTTGTATATGGCTTTCTTTTGCATTTTAAGGAAGATACTTGGAAAATTCTACTCATGGACTCCTGGCTTTGGTGCCGCTCTG
CCAGCATCTTATGTGGCCATTCTCATTGAAAGAAAAAGCAGGAGAGGGCTGCTCACAATTTATATGGCCAACTTGGCCACAGAAACACTA
TTCAGAATGGGTGTAGCAAGAGGAACCATCACAACATTAAGAAATGGAGAAGTCCTTTTGTTTTGCATCACAGCTGCCATGTACATGTTC
TTTTTCAGGTGCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGTTCCAATGGAAAATCCGTCACGTGGGCCCAGAATGAGAAG
AGCAGCCGGGGGCAGCACCTGTGGCAGCGCCTGTCCATCCACATCAACAAGAAAGAAAACCCCAACCAAACGGCCGTCATCAAGCCCTTC
CCCAAGAGCACGGAGAGCCGTGGCCTGGGCGCTGGCGCTGGCGCAGGCGGGAGCGCTGGGGGCGTGGGGGCCACGGGCGGTGCGGGCTGC
GCAGGCGCCGGCCCAGGCGGGCCCGAGTCCCCAGACGCCGGCCCCAAGGCGCTGTATGATGTGGCCGAGGCTGAGGAGCACTTCCCGGCG
CCCGCGCGGCCGCGCTCACCGTCGCCCATCAGCACGCTGAGCCACCGCGCGGGCTCGGCCAGCCGCACGGACGACGATGTGCCGTCGCTG
CACTCGGAGCCTGTGGCGCGCAGCAGCTCCTCGCAGGGCTCCCTCATGGAGCAGATCAGCAGTGTGGTCACCCGCTTCACGGCCAACATC
AGCGAGCTCAACTCCATGATGCTGTCCACCGCGGCCCCCAGCCCCGGCGTCGGCGCCCCGCTCTGCTCGTCCTACCTGATCCCCAAAGAG
ATCCAGTTGCCCACGACCATGACGACCTTTGCCGAAATCCAGCCTCTGCCGGCCATCGAAGTCACGGGAGGCGCGCAGCCCGCGGCAGGG
GCGCAGGCGGCTGGGGACGCGGCCCGGGAGAGCCCCGCGGCCGGTCCCGAGGCTGCGGCCGCCAAGCCAGACCTGGAGGAGCTGGTGGCT
CTCACCCCGCCGTCCCCCTTCAGAGACTCGGTGGACTCGGGGAGCACAACCCCCAACTCGCCAGTGTCCGAGTCGGCCCTCTGTATCCCG
TCGTCTCCCAAATATGACACTCTTATCATAAGAGATTACACTCAGAGCTCCTCGTCGTTGTGAATGTCCCTGGAAAGCACGCCGGCCTGC
GCGTGCGGAGCGGAGCCCCCCGTGTTCACACACACACAATGGCAAGCATAGTCGCCTGGTTACGGCCCAGGGGGAAGATGCCAAGGGCAC
CCCTTAATGGAAACACGAGATCAGTAGTGCTATCTCATGACAACCGACGAAGAAACCGACGACAAATCTTTTGGCAGATTTTCTTCTAGT
GGCCTTAGAAAACATGGGCTTTTAAGAAACACGGCTGATATCTTTGAGGGCTGACAAGGCGTCTCTTCAAACAGTTCCATACCAAGTGCT
TTGCTCTAGGGAAGCAGTGCGTGTGAAACAGCGTAACGGAGGGTGAAGAGCATAGTTAATAAGCAACTGTAAAAAGTTTTATTTGTTTAC
TTTAATTCTTTTCCCAGAAGAGTCTTTGATTCACCAAACATGAATGTACATTTTCTAACAAACTCAAAATCTGGGACCAAAACATCAACT
TTTTTCTTTCTTTTTTCTTTCTTTTTGTTTTTTCTTTCCTGTAAAGACCTTGAAAAGCAGTAACTTGGGTCCAGTATTTACGGAGGCGTT
GTGAATGTGTCCCATGCATAACACACTACTGGATAGTGAGTGCTGCGCTAATGTACTACGTAGGGCTTCTACCAGAGATTTTCCTCTCCA
ATTGGGTTGTGAAATACTCTTCCAAAAGCCTGCATCGGGGATTCCACCTACTTATTTCAGATTCACCTCCATTAACCAAGAAAACCAGTG

>In-frame_ENST00000305494_ENST00000305432_TCGA-EJ-7115-01A_TMEM135_chr11_87006865_-_GRM5_chr11_88242672_length(amino acids)=491AA_start in transcript=27_stop in transcript=1502
MFLVMAALSKSIPHNCYEIGHTWHPSCRVSFLQITGGALEESLKIYAPLYLIAAILRKRKLDYYLHKLLPEILQSASFLTANGALYMAFF
CILRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMANLATETLFRMGVARGTITTLRNGEVLLFCITAAMYMFFFRCKDGLK
GFTFSALSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGGPE
SPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMMLS
TAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPFRD

--------------------------------------------------------------
>In-frame_ENST00000535167_ENST00000305447_TCGA-EJ-7115-01A_TMEM135_chr11_87006865_-_GRM5_chr11_88242672_length(transcript)=2218nt_BP=523nt
CTCGTCATGGCGGCCCTCAGCAAGTCCATCCCTCATAACTGCTATGAGATCGGCCACACTTGGCACCCTTCCTGCCGGGTCTCCTTCCTG
CAGATCACCGGGGGCGCCCTGGAGGAGTCCCTGAAGATCTATGCTCCTCTGTACTTGATTGCAGCAATTCTCCGGAAACGGAAATTAGAC
TATTATTTACACAAACTACTCCCTGAGATCCTACAATCCGCTTCATTTCTAACTGCTAATGGGGCCTTGTATATGGCTTTCTTTTGCATT
TTAAGGAAGATACTTGGAAAATTCTACTCATGGACTCCTGGCTTTGGTGCCGCTCTGCCAGCATCTTATGTGGCCATTCTCATTGAAAGA
AAAAGCAGGCCACAGAAACACTATTCAGAATGGGTGTAGCAAGAGGAACCATCACAACATTAAGAAATGGAGAAGTCCTTTTGTTTTGCA
TCACAGCTGCCATGTACATGTTCTTTTTCAGGTGCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGTTCCAATGGAAAATCCG
TCACGTGGGCCCAGAATGAGAAGAGCAGCCGGGGGCAGCACCTGTGGCAGCGCCTGTCCATCCACATCAACAAGAAAGAAAACCCCAACC
AAACGGCCGTCATCAAGCCCTTCCCCAAGAGCACGGAGAGCCGTGGCCTGGGCGCTGGCGCTGGCGCAGGCGGGAGCGCTGGGGGCGTGG
GGGCCACGGGCGGTGCGGGCTGCGCAGGCGCCGGCCCAGGCGGGCCCGAGTCCCCAGACGCCGGCCCCAAGGCGCTGTATGATGTGGCCG
AGGCTGAGGAGCACTTCCCGGCGCCCGCGCGGCCGCGCTCACCGTCGCCCATCAGCACGCTGAGCCACCGCGCGGGCTCGGCCAGCCGCA
CGGACGACGATGTGCCGTCGCTGCACTCGGAGCCTGTGGCGCGCAGCAGCTCCTCGCAGGGCTCCCTCATGGAGCAGATCAGCAGTGTGG
TCACCCGCTTCACGGCCAACATCAGCGAGCTCAACTCCATGATGCTGTCCACCGCGGCCCCCAGCCCCGGCGTCGGCGCCCCGCTCTGCT
CGTCCTACCTGATCCCCAAAGAGATCCAGTTGCCCACGACCATGACGACCTTTGCCGAAATCCAGCCTCTGCCGGCCATCGAAGTCACGG
GAGGCGCGCAGCCCGCGGCAGGGGCGCAGGCGGCTGGGGACGCGGCCCGGGAGAGCCCCGCGGCCGGTCCCGAGGCTGCGGCCGCCAAGC
CAGACCTGGAGGAGCTGGTGGCTCTCACCCCGCCGTCCCCCTTCAGAGACTCGGTGGACTCGGGGAGCACAACCCCCAACTCGCCAGTGT
CCGAGTCGGCCCTCTGTATCCCGTCGTCTCCCAAATATGACACTCTTATCATAAGAGATTACACTCAGAGCTCCTCGTCGTTGTGAATGT
CCCTGGAAAGCACGCCGGCCTGCGCGTGCGGAGCGGAGCCCCCCGTGTTCACACACACACAATGGCAAGCATAGTCGCCTGGTTACGGCC
CAGGGGGAAGATGCCAAGGGCACCCCTTAATGGAAACACGAGATCAGTAGTGCTATCTCATGACAACCGACGAAGAAACCGACGACAAAT
CTTTTGGCAGATTTTCTTCTAGTGGCCTTAGAAAACATGGGCTTTTAAGAAACACGGCTGATATCTTTGAGGGCTGACAAGGCGTCTCTT
CAAACAGTTCCATACCAAGTGCTTTGCTCTAGGGAAGCAGTGCGTGTGAAACAGCGTAACGGAGGGTGAAGAGCATAGTTAATAAGCAAC
TGTAAAAAGTTTTATTTGTTTACTTTAATTCTTTTCCCAGAAGAGTCTTTGATTCACCAAACATGAATGTACATTTTCTAACAAACTCAA
AATCTGGGACCAAAACATCAACTTTTTTCTTTCTTTTTTCTTTCTTTTTGTTTTTTCTTTCCTGTAAAGACCTTGAAAAGCAGTAACTTG
GGTCCAGTATTTACGGAGGCGTTGTGAATGTGTCCCATGCATAACACACTACTGGATAGTGAGTGCTGCGCTAATGTACTACGTAGGGCT
TCTACCAGAGATTTTCCTCTCCAATTGGGTTGTGAAATACTCTTCCAAAAGCCTGCATCGGGGATTCCACCTACTTATTTCAGATTCACC

>In-frame_ENST00000535167_ENST00000305447_TCGA-EJ-7115-01A_TMEM135_chr11_87006865_-_GRM5_chr11_88242672_length(amino acids)=348AA_start in transcript=389_stop in transcript=1435
MGVARGTITTLRNGEVLLFCITAAMYMFFFRCKDGLKGFTFSALSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPK
STESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGGPESPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHS
EPVARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQ

--------------------------------------------------------------
>In-frame_ENST00000535167_ENST00000305432_TCGA-EJ-7115-01A_TMEM135_chr11_87006865_-_GRM5_chr11_88242672_length(transcript)=2218nt_BP=523nt
CTCGTCATGGCGGCCCTCAGCAAGTCCATCCCTCATAACTGCTATGAGATCGGCCACACTTGGCACCCTTCCTGCCGGGTCTCCTTCCTG
CAGATCACCGGGGGCGCCCTGGAGGAGTCCCTGAAGATCTATGCTCCTCTGTACTTGATTGCAGCAATTCTCCGGAAACGGAAATTAGAC
TATTATTTACACAAACTACTCCCTGAGATCCTACAATCCGCTTCATTTCTAACTGCTAATGGGGCCTTGTATATGGCTTTCTTTTGCATT
TTAAGGAAGATACTTGGAAAATTCTACTCATGGACTCCTGGCTTTGGTGCCGCTCTGCCAGCATCTTATGTGGCCATTCTCATTGAAAGA
AAAAGCAGGCCACAGAAACACTATTCAGAATGGGTGTAGCAAGAGGAACCATCACAACATTAAGAAATGGAGAAGTCCTTTTGTTTTGCA
TCACAGCTGCCATGTACATGTTCTTTTTCAGGTGCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGTTCCAATGGAAAATCCG
TCACGTGGGCCCAGAATGAGAAGAGCAGCCGGGGGCAGCACCTGTGGCAGCGCCTGTCCATCCACATCAACAAGAAAGAAAACCCCAACC
AAACGGCCGTCATCAAGCCCTTCCCCAAGAGCACGGAGAGCCGTGGCCTGGGCGCTGGCGCTGGCGCAGGCGGGAGCGCTGGGGGCGTGG
GGGCCACGGGCGGTGCGGGCTGCGCAGGCGCCGGCCCAGGCGGGCCCGAGTCCCCAGACGCCGGCCCCAAGGCGCTGTATGATGTGGCCG
AGGCTGAGGAGCACTTCCCGGCGCCCGCGCGGCCGCGCTCACCGTCGCCCATCAGCACGCTGAGCCACCGCGCGGGCTCGGCCAGCCGCA
CGGACGACGATGTGCCGTCGCTGCACTCGGAGCCTGTGGCGCGCAGCAGCTCCTCGCAGGGCTCCCTCATGGAGCAGATCAGCAGTGTGG
TCACCCGCTTCACGGCCAACATCAGCGAGCTCAACTCCATGATGCTGTCCACCGCGGCCCCCAGCCCCGGCGTCGGCGCCCCGCTCTGCT
CGTCCTACCTGATCCCCAAAGAGATCCAGTTGCCCACGACCATGACGACCTTTGCCGAAATCCAGCCTCTGCCGGCCATCGAAGTCACGG
GAGGCGCGCAGCCCGCGGCAGGGGCGCAGGCGGCTGGGGACGCGGCCCGGGAGAGCCCCGCGGCCGGTCCCGAGGCTGCGGCCGCCAAGC
CAGACCTGGAGGAGCTGGTGGCTCTCACCCCGCCGTCCCCCTTCAGAGACTCGGTGGACTCGGGGAGCACAACCCCCAACTCGCCAGTGT
CCGAGTCGGCCCTCTGTATCCCGTCGTCTCCCAAATATGACACTCTTATCATAAGAGATTACACTCAGAGCTCCTCGTCGTTGTGAATGT
CCCTGGAAAGCACGCCGGCCTGCGCGTGCGGAGCGGAGCCCCCCGTGTTCACACACACACAATGGCAAGCATAGTCGCCTGGTTACGGCC
CAGGGGGAAGATGCCAAGGGCACCCCTTAATGGAAACACGAGATCAGTAGTGCTATCTCATGACAACCGACGAAGAAACCGACGACAAAT
CTTTTGGCAGATTTTCTTCTAGTGGCCTTAGAAAACATGGGCTTTTAAGAAACACGGCTGATATCTTTGAGGGCTGACAAGGCGTCTCTT
CAAACAGTTCCATACCAAGTGCTTTGCTCTAGGGAAGCAGTGCGTGTGAAACAGCGTAACGGAGGGTGAAGAGCATAGTTAATAAGCAAC
TGTAAAAAGTTTTATTTGTTTACTTTAATTCTTTTCCCAGAAGAGTCTTTGATTCACCAAACATGAATGTACATTTTCTAACAAACTCAA
AATCTGGGACCAAAACATCAACTTTTTTCTTTCTTTTTTCTTTCTTTTTGTTTTTTCTTTCCTGTAAAGACCTTGAAAAGCAGTAACTTG
GGTCCAGTATTTACGGAGGCGTTGTGAATGTGTCCCATGCATAACACACTACTGGATAGTGAGTGCTGCGCTAATGTACTACGTAGGGCT
TCTACCAGAGATTTTCCTCTCCAATTGGGTTGTGAAATACTCTTCCAAAAGCCTGCATCGGGGATTCCACCTACTTATTTCAGATTCACC

>In-frame_ENST00000535167_ENST00000305432_TCGA-EJ-7115-01A_TMEM135_chr11_87006865_-_GRM5_chr11_88242672_length(amino acids)=348AA_start in transcript=389_stop in transcript=1435
MGVARGTITTLRNGEVLLFCITAAMYMFFFRCKDGLKGFTFSALSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPK
STESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGGPESPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHS
EPVARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TMEM135-GRM5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMEM135-GRM5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGRM5P41594DB06201RufinamideInhibitorSmall moleculeApproved
TgeneGRM5P41594DB06201RufinamideInhibitorSmall moleculeApproved
TgeneGRM5P41594DB06201RufinamideInhibitorSmall moleculeApproved
TgeneGRM5P41594DB00659AcamprosateAntagonistSmall moleculeApproved|Investigational
TgeneGRM5P41594DB00659AcamprosateAntagonistSmall moleculeApproved|Investigational
TgeneGRM5P41594DB00659AcamprosateAntagonistSmall moleculeApproved|Investigational

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Related Diseases for TMEM135-GRM5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMEM135C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneTMEM135C0017636Glioblastoma1CTD_human
HgeneTMEM135C0020796Profound Mental Retardation1CTD_human
HgeneTMEM135C0025363Mental Retardation, Psychosocial1CTD_human
HgeneTMEM135C0334588Giant Cell Glioblastoma1CTD_human
HgeneTMEM135C0917816Mental deficiency1CTD_human
HgeneTMEM135C1621958Glioblastoma Multiforme1CTD_human
HgeneTMEM135C3714756Intellectual Disability1CTD_human
TgeneGRM5C0036341Schizophrenia3PSYGENET
TgeneGRM5C0041696Unipolar Depression3PSYGENET
TgeneGRM5C1269683Major Depressive Disorder3PSYGENET
TgeneGRM5C0038220Status Epilepticus2CTD_human
TgeneGRM5C0041671Attention Deficit Disorder2CTD_human
TgeneGRM5C0270823Petit mal status2CTD_human
TgeneGRM5C0311335Grand Mal Status Epilepticus2CTD_human
TgeneGRM5C0393734Complex Partial Status Epilepticus2CTD_human
TgeneGRM5C0751522Status Epilepticus, Subclinical2CTD_human
TgeneGRM5C0751523Non-Convulsive Status Epilepticus2CTD_human
TgeneGRM5C0751524Simple Partial Status Epilepticus2CTD_human
TgeneGRM5C1263846Attention deficit hyperactivity disorder2CTD_human
TgeneGRM5C1321905Minimal Brain Dysfunction2CTD_human
TgeneGRM5C0005586Bipolar Disorder1PSYGENET
TgeneGRM5C0009171Cocaine Abuse1CTD_human
TgeneGRM5C0011882Diabetic Neuropathies1CTD_human
TgeneGRM5C0013146Drug abuse1CTD_human
TgeneGRM5C0013170Drug habituation1CTD_human
TgeneGRM5C0013222Drug Use Disorders1CTD_human
TgeneGRM5C0014556Epilepsy, Temporal Lobe1CTD_human
TgeneGRM5C0014558Uncinate Epilepsy1CTD_human
TgeneGRM5C0027796Neuralgia1CTD_human
TgeneGRM5C0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneGRM5C0038580Substance Dependence1CTD_human
TgeneGRM5C0038586Substance Use Disorders1CTD_human
TgeneGRM5C0038870Neuralgia, Supraorbital1CTD_human
TgeneGRM5C0042656Neuralgia, Vidian1CTD_human
TgeneGRM5C0234247Neuralgia, Atypical1CTD_human
TgeneGRM5C0234249Neuralgia, Stump1CTD_human
TgeneGRM5C0236736Cocaine-Related Disorders1CTD_human
TgeneGRM5C0236969Substance-Related Disorders1CTD_human
TgeneGRM5C0271673Symmetric Diabetic Proximal Motor Neuropathy1CTD_human
TgeneGRM5C0271674Asymmetric Diabetic Proximal Motor Neuropathy1CTD_human
TgeneGRM5C0271678Diabetic Mononeuropathy1CTD_human
TgeneGRM5C0271680Diabetic Polyneuropathies1CTD_human
TgeneGRM5C0271685Diabetic Amyotrophy1CTD_human
TgeneGRM5C0271686Diabetic Autonomic Neuropathy1CTD_human
TgeneGRM5C0393672Epilepsy, Benign Psychomotor, Childhood1CTD_human
TgeneGRM5C0393682Epilepsy, Lateral Temporal1CTD_human
TgeneGRM5C0393835Diabetic Asymmetric Polyneuropathy1CTD_human
TgeneGRM5C0423711Neuralgia, Perineal1CTD_human
TgeneGRM5C0423712Neuralgia, Iliohypogastric Nerve1CTD_human
TgeneGRM5C0600427Cocaine Dependence1CTD_human
TgeneGRM5C0740858Substance abuse problem1CTD_human
TgeneGRM5C0751074Diabetic Neuralgia1CTD_human
TgeneGRM5C0751371Neuralgia, Ilioinguinal1CTD_human
TgeneGRM5C0751372Nerve Pain1CTD_human
TgeneGRM5C0751373Paroxysmal Nerve Pain1CTD_human
TgeneGRM5C1510472Drug Dependence1CTD_human
TgeneGRM5C4316881Prescription Drug Abuse1CTD_human