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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMEM138-TNRC18 (FusionGDB2 ID:91056)

Fusion Gene Summary for TMEM138-TNRC18

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM138-TNRC18
Fusion gene ID: 91056
HgeneTgene
Gene symbol

TMEM138

TNRC18

Gene ID

51524

84629

Gene nametransmembrane protein 138trinucleotide repeat containing 18
SynonymsHSPC196CAGL79|TNRC18A
Cytomap

11q12.2

7p22.1

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 138trinucleotide repeat-containing gene 18 proteinlong CAG trinucleotide repeat-containing gene 79 protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000278826, ENST00000542946, 
ENST00000540194, ENST00000381787, 
ENST00000399537, ENST00000430969, 
ENST00000399434, 
Fusion gene scores* DoF score4 X 3 X 3=3615 X 15 X 4=900
# samples 416
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(16/900*10)=-2.49185309632967
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM138 [Title/Abstract] AND TNRC18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMEM138(61135470)-TNRC18(5353494), # samples:1
Anticipated loss of major functional domain due to fusion event.TMEM138-TNRC18 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TMEM138 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TNRC18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-2563-01ATMEM138chr11

61135470

+TNRC18chr7

5353494

-


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Fusion Gene ORF analysis for TMEM138-TNRC18

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000278826ENST00000399537TMEM138chr11

61135470

+TNRC18chr7

5353494

-
In-frameENST00000278826ENST00000430969TMEM138chr11

61135470

+TNRC18chr7

5353494

-
5CDS-intronENST00000278826ENST00000399434TMEM138chr11

61135470

+TNRC18chr7

5353494

-
3UTR-3CDSENST00000542946ENST00000399537TMEM138chr11

61135470

+TNRC18chr7

5353494

-
3UTR-3CDSENST00000542946ENST00000430969TMEM138chr11

61135470

+TNRC18chr7

5353494

-
3UTR-intronENST00000542946ENST00000399434TMEM138chr11

61135470

+TNRC18chr7

5353494

-
intron-3CDSENST00000540194ENST00000399537TMEM138chr11

61135470

+TNRC18chr7

5353494

-
intron-3CDSENST00000540194ENST00000430969TMEM138chr11

61135470

+TNRC18chr7

5353494

-
intron-intronENST00000540194ENST00000399434TMEM138chr11

61135470

+TNRC18chr7

5353494

-
Frame-shiftENST00000381787ENST00000399537TMEM138chr11

61135470

+TNRC18chr7

5353494

-
In-frameENST00000381787ENST00000430969TMEM138chr11

61135470

+TNRC18chr7

5353494

-
5CDS-intronENST00000381787ENST00000399434TMEM138chr11

61135470

+TNRC18chr7

5353494

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000278826TMEM138chr1161135470+ENST00000430969TNRC18chr75353494-41219355172814765
ENST00000381787TMEM138chr1161135470+ENST00000430969TNRC18chr75353494-37765903882469693

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000278826ENST00000430969TMEM138chr1161135470+TNRC18chr75353494-0.0154395770.9845604
ENST00000381787ENST00000430969TMEM138chr1161135470+TNRC18chr75353494-0.0186869820.981313

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Fusion Genomic Features for TMEM138-TNRC18


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM138-TNRC18


check button Go to

FGviewer for the breakpoints of chr11:61135470-chr7:5353494

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM138chr11:61135470chr7:5353494ENST00000278826+4541_61125.33333333333333163.0TransmembraneHelical
HgeneTMEM138chr11:61135470chr7:5353494ENST00000278826+457_27125.33333333333333163.0TransmembraneHelical
HgeneTMEM138chr11:61135470chr7:5353494ENST00000278826+4580_100125.33333333333333163.0TransmembraneHelical
TgeneTNRC18chr11:61135470chr7:5353494ENST0000043096925302353_24372342.33333333333352969.0Compositional biasNote=Pro-rich
TgeneTNRC18chr11:61135470chr7:5353494ENST0000043096925302557_26812342.33333333333352969.0Compositional biasNote=Ser-rich
TgeneTNRC18chr11:61135470chr7:5353494ENST0000043096925302817_29622342.33333333333352969.0DomainBAH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM138chr11:61135470chr7:5353494ENST00000278826+45110_130125.33333333333333163.0TransmembraneHelical
HgeneTMEM138chr11:61135470chr7:5353494ENST00000542946+13110_1300106.0TransmembraneHelical
HgeneTMEM138chr11:61135470chr7:5353494ENST00000542946+1341_610106.0TransmembraneHelical
HgeneTMEM138chr11:61135470chr7:5353494ENST00000542946+137_270106.0TransmembraneHelical
HgeneTMEM138chr11:61135470chr7:5353494ENST00000542946+1380_1000106.0TransmembraneHelical
TgeneTNRC18chr11:61135470chr7:5353494ENST0000043096925301481_15162342.33333333333352969.0Coiled coilOntology_term=ECO:0000255
TgeneTNRC18chr11:61135470chr7:5353494ENST000004309692530916_9492342.33333333333352969.0Coiled coilOntology_term=ECO:0000255
TgeneTNRC18chr11:61135470chr7:5353494ENST0000043096925301828_18412342.33333333333352969.0Compositional biasNote=Poly-Glu
TgeneTNRC18chr11:61135470chr7:5353494ENST000004309692530326_5062342.33333333333352969.0Compositional biasNote=Pro-rich
TgeneTNRC18chr11:61135470chr7:5353494ENST000004309692530968_11922342.33333333333352969.0Compositional biasNote=Pro-rich


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Fusion Gene Sequence for TMEM138-TNRC18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000278826_ENST00000430969_TCGA-06-2563-01A_TMEM138_chr11_61135470_+_TNRC18_chr7_5353494_length(transcript)=4121nt_BP=935nt
GCTAACCCCCTAACTCCCGTTCCTCCTCGGCGTTTCTTCTCCAAGTCCGAAGTCAGGGTCCAGGACTGCTGCGATGCATCAGCCCCGCCT
CTCATCCCCCATCCAGAGGAGGCGGAAATGTTCAGGTGAACGCGAAGCCTCCCACTACGAGCCGGCCCTCAGCAAGGCCGTGCGCAGTGT
GGGCGGGAGCCCTAAGTCAGCTAGCGGCGACGCTGGGAGGGCCCGGAGCAGGCCGGGCCCCGAACAGCGAAAGCTCCAACATGGCGGCCA
GACTGGCCATAGAGCGGGAAGAGAAAGCCGGGGACTAGCAGGCCGCACGGCGCAGACGGGGCCCGCCTCCTCCATTTACTTCCGGAATTT
AAAGCCGGCTTCCGGAAGCCGGGACGATGTCCGCATGACAACCGACGTTGGAGTTTGGAGGTGCTTGCCTTAGAGCAAGGGAAACAGCTC
TCATTCAAAGGAACTAGAAGCCTCTCCCTCAGTGGTAGGGAGACAGCCAGGAGCGGTTTTCTGGGAACTGTGGGATGTGCCCTTGGGGGC
CCGAGAAAACAGAAGGAAGATGCTCCAGACCAGTAACTACAGCCTGGTGCTCTCTCTGCAGTTCCTGCTGCTGTCCTATGACCTCTTTGT
CAATTCCTTCTCAGAACTGCTCCAAAAGACTCCTGTCATCCAGCTTGTGCTCTTCATCATCCAGGATATTGCAGTCCTCTTCAACATCAT
CATCATTTTCCTCATGTTCTTCAACACCTTCGTCTTCCAGGCTGGCCTGGTCAACCTCCTATTCCATAAGTTCAAAGGGACCATCATCCT
GACAGCTGTGTACTTTGCCCTCAGCATCTCCCTTCATGTCTGGGTCATGAACTTACGCTGGAAAAACTCCAACAGCTTCATATGGACAGA
TGGACTTCAAATGCTGTTTGTATTCCAGAGACTAGACAGAGCCGCTACCCTGGAGGAGGGGAACCCAACAGACGAGGTCCCCAGTACCCC
CTTAGCCCTGGAGCCGAGCAGCACCCCAGGTTCCAAGAAGAGCCCCCCAGAGCCTGTGGACAAGCGAGCCAAGGCCCCCAAGGCGCGCCC
GGCACCGCCGCAGCCCAGTCCCGCACCACCCGCCTTCACCAGCTGCCCAGCACCCGAGCCATTTGCAGAGCTGCCAGCTCCTGCCACCTC
CCTGGCCCCAGCACCCCTCATCACCATGCCTGCCACACGCCCCAAGCCCAAGAAGGCGCGGGCAGCCGAGGAGTCGGGTGCCAAGGGCCC
TCGGAGGCCGGGGGAGGAGGCCGAGCTGCTTGTCAAACTGGACCACGAGGGTGTCACGTCACCCAAAAGCAAGAAGGCTAAAGAGGCCCT
GCTGCTCCGGGAGGATCCGGGGGCGGGGGGCTGGCAGGAGCCCAAGAGCCTCCTGAGCCTGGGCAGCTATCCCCCCGCGGCCGGCAGCAG
CGAGCCCAAGGCACCCTGGCCCAAGGCCACCGACGGGGACCTCGCCCAGGAGCCCGGGCCGGGGCTCACGTTCGAGGACTCTGGGAACCC
CAAGAGCCCAGACAAGGCCCAGGCTGAGCAGGACGGGGCCGAAGAGTCCGAGAGCAGCAGCAGCAGCAGTAGTGGCAGCAGTAGCAGCAG
CAGCAGCAGCAGCAGCAGCGGCTCGGAGACAGAAGGGGAGGAGGAAGGCGACAAGAACGGGGACGGGGGCTGCGGCACCGGGGGCCGTAA
CTGCAGCGCTGCCAGCTCCAGGGCGGCCTCACCGGCCTCCTCCTCCTCCTCCTCATCCTCCTCCTCCTCCTCCTCCTCCTCCTCATCCTC
CTCTTCCTCCTCCTCCTCTTCCTCCTCCTCCTCTTCCTCTTCGTCTTCCTCCTCTTCCTCCTCCTCCTCTTCCTCGTCCTCATCCTCCTC
CTCCTCCTCCTCTTCCTCCTCTTCTTCCTCCACCACAGACGAGGACTCTTCCTGCAGCTCGGACGATGAGGCAGCCCCCGCCCCCACGGC
TGGCCCTTCCGCGCAGGCGGCGCTCCCCACCAAGGCCACCAAGCAGGCCGGCAAGGCGCGGCCCTCGGCCCACTCCCCAGGCAAGAAGAC
GCCCGCGCCCCAGCCCCAGGCGCCTCCTCCGCAGCCCACACAGCCTCTGCAGCCCAAGGCTCAGGCCGGGGCCAAGAGCCGACCCAAGAA
GAGAGAGGGCGTCCACCTCCCCACCACCAAGGAGCTGGCCAAGCGGCAGCGCCTGCCGTCCGTGGAGAACCGGCCCAAGATCGCCGCCTT
CCTGCCAGCCCGGCAGCTCTGGAAGTGGTTCGGCAAGCCCACCCAGCGGCGTGGCATGAAGGGCAAGGCCCGCAAGCTCTTCTACAAGGC
CATCGTGCGCGGCAAGGAGATGATCCGTATCGGGGACTGTGCCGTGTTCCTCTCTGCCGGCCGCCCCAACCTGCCCTACATCGGCCGCAT
CCAGAGCATGTGGGAGTCGTGGGGCAACAACATGGTGGTCCGCGTCAAGTGGTTCTACCACCCCGAGGAGACCAGCCCGGGCAAGCAGTT
CCACCAGGGCCAGCACTGGGACCAGAAGTCCAGCCGCAGCCTCCCGGCGGCCCTGCGGGTCTCCAGCCAGAGGAAGGACTTCATGGAGCG
CGCGCTATACCAGTCCTCGCATGTGGACGAAAATGACGTGCAGACGGTGTCGCACAAGTGCCTGGTGGTGGGCCTGGAGCAGTATGAGCA
GATGCTGAAGACCAAGAAGTACCAGGACAGCGAGGGCCTGTACTACCTCGCGGGCACCTACGAGCCCACCACGGGCATGATCTTCTCCAC
GGACGGCGTGCCCGTGCTCTGCTGAGCCCGCCGGGCCCTGCGGGCCACCTGTGCCCCGAGGGCGGCCAGGGACCCATCTCCATCACTGCC
ATGGCGCGGAGACCACGTGCGTTGTGTGCATGCGAGCGCTCCTGCAGGCGTGTGCATGGGGCCAGGTGTGCACGTGGATGCCCGGGTGAG
TGTGTGTGCATGCACGTGTGTGCACGCATGTGCACATGCCTCCAGCCCCACCTTCCAACCCCTCAGTGCCCCCAGGACAGGGGCCCCTCT
TAGCTATCAGGGTATGGCCGGACCGGCCCTTCCTGCCCAGCACGTTGCAAGCACTTGGCCAGGCCGGCCCTCCAGGCTGCTGCTGCGTGG
GGGCCCGGGTGCCCCCAGGTCCATGCAGACTGGGGATTCGGTGGGGAGGGGCGCTTCTAAGGAACCAAACTGACGCTCACTCTGGGCTTC
CCAAGCACCCTTAGCATGGAGCCCACCCCAAGGCCTCCCACCGTGCATGGGACAGGGCAGCCCGATGCCAGCTGGCCTACCTGACTGTGC
CAGGGGCCCTGCCCCCACCCTCTCAGGATGGCCTAGACTTGGGGAACAGAGCCGGGTGGGGTTGCAGCCCGGAGTGTCTGTCAAAGGCAC
CAGGTGGAGAGGGCCCGGCACAGGCCCACCCTGGTCCAAACCCTCACACTACAGAAAACCCCAATGGTGCTGAAACTGTCGCCCGGCCAC
GCCTGGCCCCTCCCCACCCAGGAGGGAGGTGGCACTTCTTAACCTGTACAGTTTTATTGTACCAAGAGACTCGCCCCGCCCCTGTATCAT
AAGCCTTTAAATGGAGTCAACTTTTTAATTATATATATAAAGATAAATATATATAAATATATATATAAACTTTTTAAAACTGTGAAAAAT
AGCTATGAAATTATAAAAAAAAACATTCTGACGTGCAGAATATTATTTTTTATTTCCTGTTAGATTATAGTGTCTAGCACCGGCTTCACC
GGCCTCCCAGTCCCCAGCACACCCCCCGCCCACCCCACCAAGTGTACTGTACTCACCCCCCAGGATAGAGAAGTGTTTGTTAGGGAGAGA
AGAGGGAGAGGCAGGAGCCGGCCCAAGCCCAGGGTCCCTGCTTGGGCCCCAGAAAGCACTTAACCAGGCCCCAAGCCTTCAAGGGAAACC
AAGGCCTCAACCAGACAATCTTGAGGGAAGGAAAAGCCAGACTTTGGGTTTGTTTTTTGGGGGAATTATTGGTTTTTTTTTTTATGTTTC

>In-frame_ENST00000278826_ENST00000430969_TCGA-06-2563-01A_TMEM138_chr11_61135470_+_TNRC18_chr7_5353494_length(amino acids)=765AA_start in transcript=517_stop in transcript=2814
MWDVPLGARENRRKMLQTSNYSLVLSLQFLLLSYDLFVNSFSELLQKTPVIQLVLFIIQDIAVLFNIIIIFLMFFNTFVFQAGLVNLLFH
KFKGTIILTAVYFALSISLHVWVMNLRWKNSNSFIWTDGLQMLFVFQRLDRAATLEEGNPTDEVPSTPLALEPSSTPGSKKSPPEPVDKR
AKAPKARPAPPQPSPAPPAFTSCPAPEPFAELPAPATSLAPAPLITMPATRPKPKKARAAEESGAKGPRRPGEEAELLVKLDHEGVTSPK
SKKAKEALLLREDPGAGGWQEPKSLLSLGSYPPAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSS
SSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS
SSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQAPPPQPTQPLQPKAQA
GAKSRPKKREGVHLPTTKELAKRQRLPSVENRPKIAAFLPARQLWKWFGKPTQRRGMKGKARKLFYKAIVRGKEMIRIGDCAVFLSAGRP
NLPYIGRIQSMWESWGNNMVVRVKWFYHPEETSPGKQFHQGQHWDQKSSRSLPAALRVSSQRKDFMERALYQSSHVDENDVQTVSHKCLV

--------------------------------------------------------------
>In-frame_ENST00000381787_ENST00000430969_TCGA-06-2563-01A_TMEM138_chr11_61135470_+_TNRC18_chr7_5353494_length(transcript)=3776nt_BP=590nt
TGGGCAACAGAATGAAACCCTGTCTCGAAAAATAAGGAGTATCAGAGAATCTTCTATAGGACTATGTATGGAAGAAATTTTAAAAATAAA
AAAGAGTATTAGAGCAGGAAAGCCTTGACTATGGACTGCAAACCCAACTGATGGGGCCAGTGGGTAATTTTAGGTAATTTTAGCTTCATG
TCATTCAGGTCCCAAAACCCATGTTATCTCTGTGAGGGTTTAAGATGTCAGATGCCTATCTCACAACAAAGGACAGGCCTCGTGGTGTCC
CTCAGGACATAGTACCTGCTCTTGGGTCCTCACACAGGCCTTCATTGGTTGTACTTTTTTTTATGTCTACAGCATCCAGGATATTGCAGT
CCTCTTCAACATCATCATCATTTTCCTCATGTTCTTCAACACCTTCGTCTTCCAGGCTGGCCTGGTCAACCTCCTATTCCATAAGTTCAA
AGGGACCATCATCCTGACAGCTGTGTACTTTGCCCTCAGCATCTCCCTTCATGTCTGGGTCATGAACTTACGCTGGAAAAACTCCAACAG
CTTCATATGGACAGATGGACTTCAAATGCTGTTTGTATTCCAGAGACTAGACAGAGCCGCTACCCTGGAGGAGGGGAACCCAACAGACGA
GGTCCCCAGTACCCCCTTAGCCCTGGAGCCGAGCAGCACCCCAGGTTCCAAGAAGAGCCCCCCAGAGCCTGTGGACAAGCGAGCCAAGGC
CCCCAAGGCGCGCCCGGCACCGCCGCAGCCCAGTCCCGCACCACCCGCCTTCACCAGCTGCCCAGCACCCGAGCCATTTGCAGAGCTGCC
AGCTCCTGCCACCTCCCTGGCCCCAGCACCCCTCATCACCATGCCTGCCACACGCCCCAAGCCCAAGAAGGCGCGGGCAGCCGAGGAGTC
GGGTGCCAAGGGCCCTCGGAGGCCGGGGGAGGAGGCCGAGCTGCTTGTCAAACTGGACCACGAGGGTGTCACGTCACCCAAAAGCAAGAA
GGCTAAAGAGGCCCTGCTGCTCCGGGAGGATCCGGGGGCGGGGGGCTGGCAGGAGCCCAAGAGCCTCCTGAGCCTGGGCAGCTATCCCCC
CGCGGCCGGCAGCAGCGAGCCCAAGGCACCCTGGCCCAAGGCCACCGACGGGGACCTCGCCCAGGAGCCCGGGCCGGGGCTCACGTTCGA
GGACTCTGGGAACCCCAAGAGCCCAGACAAGGCCCAGGCTGAGCAGGACGGGGCCGAAGAGTCCGAGAGCAGCAGCAGCAGCAGTAGTGG
CAGCAGTAGCAGCAGCAGCAGCAGCAGCAGCAGCGGCTCGGAGACAGAAGGGGAGGAGGAAGGCGACAAGAACGGGGACGGGGGCTGCGG
CACCGGGGGCCGTAACTGCAGCGCTGCCAGCTCCAGGGCGGCCTCACCGGCCTCCTCCTCCTCCTCCTCATCCTCCTCCTCCTCCTCCTC
CTCCTCCTCATCCTCCTCTTCCTCCTCCTCCTCTTCCTCCTCCTCCTCTTCCTCTTCGTCTTCCTCCTCTTCCTCCTCCTCCTCTTCCTC
GTCCTCATCCTCCTCCTCCTCCTCCTCTTCCTCCTCTTCTTCCTCCACCACAGACGAGGACTCTTCCTGCAGCTCGGACGATGAGGCAGC
CCCCGCCCCCACGGCTGGCCCTTCCGCGCAGGCGGCGCTCCCCACCAAGGCCACCAAGCAGGCCGGCAAGGCGCGGCCCTCGGCCCACTC
CCCAGGCAAGAAGACGCCCGCGCCCCAGCCCCAGGCGCCTCCTCCGCAGCCCACACAGCCTCTGCAGCCCAAGGCTCAGGCCGGGGCCAA
GAGCCGACCCAAGAAGAGAGAGGGCGTCCACCTCCCCACCACCAAGGAGCTGGCCAAGCGGCAGCGCCTGCCGTCCGTGGAGAACCGGCC
CAAGATCGCCGCCTTCCTGCCAGCCCGGCAGCTCTGGAAGTGGTTCGGCAAGCCCACCCAGCGGCGTGGCATGAAGGGCAAGGCCCGCAA
GCTCTTCTACAAGGCCATCGTGCGCGGCAAGGAGATGATCCGTATCGGGGACTGTGCCGTGTTCCTCTCTGCCGGCCGCCCCAACCTGCC
CTACATCGGCCGCATCCAGAGCATGTGGGAGTCGTGGGGCAACAACATGGTGGTCCGCGTCAAGTGGTTCTACCACCCCGAGGAGACCAG
CCCGGGCAAGCAGTTCCACCAGGGCCAGCACTGGGACCAGAAGTCCAGCCGCAGCCTCCCGGCGGCCCTGCGGGTCTCCAGCCAGAGGAA
GGACTTCATGGAGCGCGCGCTATACCAGTCCTCGCATGTGGACGAAAATGACGTGCAGACGGTGTCGCACAAGTGCCTGGTGGTGGGCCT
GGAGCAGTATGAGCAGATGCTGAAGACCAAGAAGTACCAGGACAGCGAGGGCCTGTACTACCTCGCGGGCACCTACGAGCCCACCACGGG
CATGATCTTCTCCACGGACGGCGTGCCCGTGCTCTGCTGAGCCCGCCGGGCCCTGCGGGCCACCTGTGCCCCGAGGGCGGCCAGGGACCC
ATCTCCATCACTGCCATGGCGCGGAGACCACGTGCGTTGTGTGCATGCGAGCGCTCCTGCAGGCGTGTGCATGGGGCCAGGTGTGCACGT
GGATGCCCGGGTGAGTGTGTGTGCATGCACGTGTGTGCACGCATGTGCACATGCCTCCAGCCCCACCTTCCAACCCCTCAGTGCCCCCAG
GACAGGGGCCCCTCTTAGCTATCAGGGTATGGCCGGACCGGCCCTTCCTGCCCAGCACGTTGCAAGCACTTGGCCAGGCCGGCCCTCCAG
GCTGCTGCTGCGTGGGGGCCCGGGTGCCCCCAGGTCCATGCAGACTGGGGATTCGGTGGGGAGGGGCGCTTCTAAGGAACCAAACTGACG
CTCACTCTGGGCTTCCCAAGCACCCTTAGCATGGAGCCCACCCCAAGGCCTCCCACCGTGCATGGGACAGGGCAGCCCGATGCCAGCTGG
CCTACCTGACTGTGCCAGGGGCCCTGCCCCCACCCTCTCAGGATGGCCTAGACTTGGGGAACAGAGCCGGGTGGGGTTGCAGCCCGGAGT
GTCTGTCAAAGGCACCAGGTGGAGAGGGCCCGGCACAGGCCCACCCTGGTCCAAACCCTCACACTACAGAAAACCCCAATGGTGCTGAAA
CTGTCGCCCGGCCACGCCTGGCCCCTCCCCACCCAGGAGGGAGGTGGCACTTCTTAACCTGTACAGTTTTATTGTACCAAGAGACTCGCC
CCGCCCCTGTATCATAAGCCTTTAAATGGAGTCAACTTTTTAATTATATATATAAAGATAAATATATATAAATATATATATAAACTTTTT
AAAACTGTGAAAAATAGCTATGAAATTATAAAAAAAAACATTCTGACGTGCAGAATATTATTTTTTATTTCCTGTTAGATTATAGTGTCT
AGCACCGGCTTCACCGGCCTCCCAGTCCCCAGCACACCCCCCGCCCACCCCACCAAGTGTACTGTACTCACCCCCCAGGATAGAGAAGTG
TTTGTTAGGGAGAGAAGAGGGAGAGGCAGGAGCCGGCCCAAGCCCAGGGTCCCTGCTTGGGCCCCAGAAAGCACTTAACCAGGCCCCAAG
CCTTCAAGGGAAACCAAGGCCTCAACCAGACAATCTTGAGGGAAGGAAAAGCCAGACTTTGGGTTTGTTTTTTGGGGGAATTATTGGTTT

>In-frame_ENST00000381787_ENST00000430969_TCGA-06-2563-01A_TMEM138_chr11_61135470_+_TNRC18_chr7_5353494_length(amino acids)=693AA_start in transcript=388_stop in transcript=2469
MFFNTFVFQAGLVNLLFHKFKGTIILTAVYFALSISLHVWVMNLRWKNSNSFIWTDGLQMLFVFQRLDRAATLEEGNPTDEVPSTPLALE
PSSTPGSKKSPPEPVDKRAKAPKARPAPPQPSPAPPAFTSCPAPEPFAELPAPATSLAPAPLITMPATRPKPKKARAAEESGAKGPRRPG
EEAELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQEPKSLLSLGSYPPAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPD
KAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSS
SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQ
PQAPPPQPTQPLQPKAQAGAKSRPKKREGVHLPTTKELAKRQRLPSVENRPKIAAFLPARQLWKWFGKPTQRRGMKGKARKLFYKAIVRG
KEMIRIGDCAVFLSAGRPNLPYIGRIQSMWESWGNNMVVRVKWFYHPEETSPGKQFHQGQHWDQKSSRSLPAALRVSSQRKDFMERALYQ

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Fusion Gene PPI Analysis for TMEM138-TNRC18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMEM138-TNRC18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMEM138-TNRC18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMEM138C0431399Familial aplasia of the vermis1GENOMICS_ENGLAND
HgeneTMEM138C1855675Arima syndrome1GENOMICS_ENGLAND;ORPHANET
HgeneTMEM138C3280906JOUBERT SYNDROME 161GENOMICS_ENGLAND;UNIPROT