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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:TMEM241-PACS1 (FusionGDB2 ID:91331) |
Fusion Gene Summary for TMEM241-PACS1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: TMEM241-PACS1 | Fusion gene ID: 91331 | Hgene | Tgene | Gene symbol | TMEM241 | PACS1 | Gene ID | 85019 | 55690 |
Gene name | transmembrane protein 241 | phosphofurin acidic cluster sorting protein 1 | |
Synonyms | C18orf45|hVVT | MRD17|SHMS | |
Cytomap | 18q11.2 | 11q13.1-q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protein 241putative vertebrate vrg4-like nucleotide-sugar transporter truncated variant2putative vertebrate vrg4-like nucleotide-sugar transporter variant1transmembrane protein C18orf45 | phosphofurin acidic cluster sorting protein 1PACS-1cytosolic sorting protein PACS-1 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q24JQ0 | . | |
Ensembl transtripts involved in fusion gene | ENST00000450466, ENST00000383233, ENST00000542162, ENST00000399707, ENST00000475185, | ENST00000320580, ENST00000529757, ENST00000524815, | |
Fusion gene scores | * DoF score | 11 X 10 X 9=990 | 21 X 18 X 12=4536 |
# samples | 13 | 26 | |
** MAII score | log2(13/990*10)=-2.92891690193852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(26/4536*10)=-4.12483711191377 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TMEM241 [Title/Abstract] AND PACS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | TMEM241(20889644)-PACS1(65960957), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene breakpoints across TMEM241 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across PACS1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | HNSC | TCGA-UF-A71B-01A | TMEM241 | chr18 | 20889644 | - | PACS1 | chr11 | 65960957 | + |
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Fusion Gene ORF analysis for TMEM241-PACS1 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000450466 | ENST00000320580 | TMEM241 | chr18 | 20889644 | - | PACS1 | chr11 | 65960957 | + |
5CDS-intron | ENST00000450466 | ENST00000529757 | TMEM241 | chr18 | 20889644 | - | PACS1 | chr11 | 65960957 | + |
5CDS-intron | ENST00000450466 | ENST00000524815 | TMEM241 | chr18 | 20889644 | - | PACS1 | chr11 | 65960957 | + |
In-frame | ENST00000383233 | ENST00000320580 | TMEM241 | chr18 | 20889644 | - | PACS1 | chr11 | 65960957 | + |
5CDS-intron | ENST00000383233 | ENST00000529757 | TMEM241 | chr18 | 20889644 | - | PACS1 | chr11 | 65960957 | + |
5CDS-intron | ENST00000383233 | ENST00000524815 | TMEM241 | chr18 | 20889644 | - | PACS1 | chr11 | 65960957 | + |
3UTR-3CDS | ENST00000542162 | ENST00000320580 | TMEM241 | chr18 | 20889644 | - | PACS1 | chr11 | 65960957 | + |
3UTR-intron | ENST00000542162 | ENST00000529757 | TMEM241 | chr18 | 20889644 | - | PACS1 | chr11 | 65960957 | + |
3UTR-intron | ENST00000542162 | ENST00000524815 | TMEM241 | chr18 | 20889644 | - | PACS1 | chr11 | 65960957 | + |
intron-3CDS | ENST00000399707 | ENST00000320580 | TMEM241 | chr18 | 20889644 | - | PACS1 | chr11 | 65960957 | + |
intron-intron | ENST00000399707 | ENST00000529757 | TMEM241 | chr18 | 20889644 | - | PACS1 | chr11 | 65960957 | + |
intron-intron | ENST00000399707 | ENST00000524815 | TMEM241 | chr18 | 20889644 | - | PACS1 | chr11 | 65960957 | + |
5UTR-3CDS | ENST00000475185 | ENST00000320580 | TMEM241 | chr18 | 20889644 | - | PACS1 | chr11 | 65960957 | + |
5UTR-intron | ENST00000475185 | ENST00000529757 | TMEM241 | chr18 | 20889644 | - | PACS1 | chr11 | 65960957 | + |
5UTR-intron | ENST00000475185 | ENST00000524815 | TMEM241 | chr18 | 20889644 | - | PACS1 | chr11 | 65960957 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000450466 | TMEM241 | chr18 | 20889644 | - | ENST00000320580 | PACS1 | chr11 | 65960957 | + | 4946 | 943 | 476 | 3478 | 1000 |
ENST00000383233 | TMEM241 | chr18 | 20889644 | - | ENST00000320580 | PACS1 | chr11 | 65960957 | + | 4886 | 883 | 53 | 3418 | 1121 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000450466 | ENST00000320580 | TMEM241 | chr18 | 20889644 | - | PACS1 | chr11 | 65960957 | + | 0.000852252 | 0.9991478 |
ENST00000383233 | ENST00000320580 | TMEM241 | chr18 | 20889644 | - | PACS1 | chr11 | 65960957 | + | 0.000519203 | 0.9994808 |
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Fusion Genomic Features for TMEM241-PACS1 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
TMEM241 | chr18 | 20889643 | - | PACS1 | chr11 | 65960956 | + | 6.08E-06 | 0.9999939 |
TMEM241 | chr18 | 20889643 | - | PACS1 | chr11 | 65960956 | + | 6.08E-06 | 0.9999939 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for TMEM241-PACS1 |
Go to FGviewer for the breakpoints of chr18:20889644-chr11:65960957 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TMEM241 | . |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TMEM241 | chr18:20889644 | chr11:65960957 | ENST00000383233 | - | 14 | 15 | 121_141 | 276.6666666666667 | 297.0 | Transmembrane | Helical |
Hgene | TMEM241 | chr18:20889644 | chr11:65960957 | ENST00000383233 | - | 14 | 15 | 146_166 | 276.6666666666667 | 297.0 | Transmembrane | Helical |
Hgene | TMEM241 | chr18:20889644 | chr11:65960957 | ENST00000383233 | - | 14 | 15 | 187_207 | 276.6666666666667 | 297.0 | Transmembrane | Helical |
Hgene | TMEM241 | chr18:20889644 | chr11:65960957 | ENST00000383233 | - | 14 | 15 | 211_231 | 276.6666666666667 | 297.0 | Transmembrane | Helical |
Hgene | TMEM241 | chr18:20889644 | chr11:65960957 | ENST00000383233 | - | 14 | 15 | 250_270 | 276.6666666666667 | 297.0 | Transmembrane | Helical |
Hgene | TMEM241 | chr18:20889644 | chr11:65960957 | ENST00000383233 | - | 14 | 15 | 32_52 | 276.6666666666667 | 297.0 | Transmembrane | Helical |
Hgene | TMEM241 | chr18:20889644 | chr11:65960957 | ENST00000383233 | - | 14 | 15 | 67_87 | 276.6666666666667 | 297.0 | Transmembrane | Helical |
Hgene | TMEM241 | chr18:20889644 | chr11:65960957 | ENST00000383233 | - | 14 | 15 | 7_29 | 276.6666666666667 | 297.0 | Transmembrane | Helical |
Hgene | TMEM241 | chr18:20889644 | chr11:65960957 | ENST00000383233 | - | 14 | 15 | 93_113 | 276.6666666666667 | 297.0 | Transmembrane | Helical |
Tgene | PACS1 | chr18:20889644 | chr11:65960957 | ENST00000320580 | 0 | 24 | 353_377 | 118.66666666666667 | 964.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | PACS1 | chr18:20889644 | chr11:65960957 | ENST00000320580 | 0 | 24 | 279_283 | 118.66666666666667 | 964.0 | Compositional bias | Note=Poly-Glu | |
Tgene | PACS1 | chr18:20889644 | chr11:65960957 | ENST00000320580 | 0 | 24 | 168_175 | 118.66666666666667 | 964.0 | Region | Note=Involved in binding to AP-1 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TMEM241 | chr18:20889644 | chr11:65960957 | ENST00000383233 | - | 14 | 15 | 271_291 | 276.6666666666667 | 297.0 | Transmembrane | Helical |
Hgene | TMEM241 | chr18:20889644 | chr11:65960957 | ENST00000399707 | - | 1 | 6 | 121_141 | 0 | 124.0 | Transmembrane | Helical |
Hgene | TMEM241 | chr18:20889644 | chr11:65960957 | ENST00000399707 | - | 1 | 6 | 146_166 | 0 | 124.0 | Transmembrane | Helical |
Hgene | TMEM241 | chr18:20889644 | chr11:65960957 | ENST00000399707 | - | 1 | 6 | 187_207 | 0 | 124.0 | Transmembrane | Helical |
Hgene | TMEM241 | chr18:20889644 | chr11:65960957 | ENST00000399707 | - | 1 | 6 | 211_231 | 0 | 124.0 | Transmembrane | Helical |
Hgene | TMEM241 | chr18:20889644 | chr11:65960957 | ENST00000399707 | - | 1 | 6 | 250_270 | 0 | 124.0 | Transmembrane | Helical |
Hgene | TMEM241 | chr18:20889644 | chr11:65960957 | ENST00000399707 | - | 1 | 6 | 271_291 | 0 | 124.0 | Transmembrane | Helical |
Hgene | TMEM241 | chr18:20889644 | chr11:65960957 | ENST00000399707 | - | 1 | 6 | 32_52 | 0 | 124.0 | Transmembrane | Helical |
Hgene | TMEM241 | chr18:20889644 | chr11:65960957 | ENST00000399707 | - | 1 | 6 | 67_87 | 0 | 124.0 | Transmembrane | Helical |
Hgene | TMEM241 | chr18:20889644 | chr11:65960957 | ENST00000399707 | - | 1 | 6 | 7_29 | 0 | 124.0 | Transmembrane | Helical |
Hgene | TMEM241 | chr18:20889644 | chr11:65960957 | ENST00000399707 | - | 1 | 6 | 93_113 | 0 | 124.0 | Transmembrane | Helical |
Tgene | PACS1 | chr18:20889644 | chr11:65960957 | ENST00000320580 | 0 | 24 | 112_115 | 118.66666666666667 | 964.0 | Compositional bias | Note=Poly-Ser | |
Tgene | PACS1 | chr18:20889644 | chr11:65960957 | ENST00000320580 | 0 | 24 | 35_40 | 118.66666666666667 | 964.0 | Compositional bias | Note=Poly-Gln | |
Tgene | PACS1 | chr18:20889644 | chr11:65960957 | ENST00000320580 | 0 | 24 | 55_84 | 118.66666666666667 | 964.0 | Compositional bias | Note=Ser-rich | |
Tgene | PACS1 | chr18:20889644 | chr11:65960957 | ENST00000320580 | 0 | 24 | 5_44 | 118.66666666666667 | 964.0 | Compositional bias | Note=Gly-rich | |
Tgene | PACS1 | chr18:20889644 | chr11:65960957 | ENST00000320580 | 0 | 24 | 62_65 | 118.66666666666667 | 964.0 | Compositional bias | Note=Poly-Ala |
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Fusion Gene Sequence for TMEM241-PACS1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000450466_ENST00000320580_TCGA-UF-A71B-01A_TMEM241_chr18_20889644_-_PACS1_chr11_65960957_length(transcript)=4946nt_BP=943nt GCTGCTGCTGCGGGGGTCGGGCGGCGGCCAGGGGATTTGGGCAGGCACCGTGGATCCCCGAGAAGGGGACGAGTTGACAGATGTGCGTGA GGAGGTCTCTGGTCGGCCTCACCTTTTGTACCTGCTACCTGGCTTCTTACCTCACGAACAAGTATGTGCTGTCTGTCTTGAAATTTACCT ACCCTACATTATTCCAAGGGTGGCAGACGCTCATTGGTGGACTTTTGCTTCATGTGTCCTGGAAACTGGGCTGGGTAGAGATCAACAGCA GTTCAAGGCCATTCCTGTGTTTCTCACTTTGCATAATGTAGCTGAAGTTATCATCTGTGGGTACCAGAAGTGTTTTCAGAAAGAGAAAAC ATCTCCTGCAAAGATCTGTAGGTTGCACCTTGAAAGAACAAGACAAAACCAAACTTCAAGACTATCCTCCTGTTTAAAAGGAGACTAGCA GGTGTCAAAGAGAGGCGGTAAAGCTCATGATACCTGATGTAATCAGTGCCCTCCTCCTCCTGGCCGCAGCAGGATGCCTTCCCTTCAATG ACTCCCAGTTTAATCCAGATGGATATTTTTGGGCTATAATTCACTTACTCTGTGTAGGGGCTTATAAAATTCTACAGAAGTCCCAGAAAC CCAGTGCATTAAGTGACATTGACCAGCAATACTTAAACTATATATTCAGTGTGGTGCTCCTGGCATTTGCATCTCATCCCACAGGTGATC TCTTCAGCGTCCTGGACTTCCCATTCCTGTACTTCTACAGATTCCATGGTAGCTGCTGTGCCAGTGGATTTTTGGGATTCTTTCTCATGT TCAGTACAGTGAAGCTAAAAAACCTTCTGGCCCCAGGGCAGTGTGCAGCCTGGATTTTCTTTGCTAAGATAATCACAGCTGGCTTATCAA TATTGCTGTTTGATGCGATCCTGACCAGTGCAACCACGGGATGGCTATTCAGCTTGACCCTGAAGAAACTCGTCATGCTAAAAGAAATGG ACAAAGATCTTAACTCAGTGGTCATCGCTGTGAAGCTGCAGGGTTCAAAAAGAATTCTTCGCTCCAACGAGATCGTCCTTCCAGCTAGTG GACTGGTGGAAACAGAGCTCCAATTAACCTTCTCCCTTCAGTACCCTCATTTCCTTAAGCGAGATGCCAACAAGCTGCAGATCATGCTGC AAAGGAGAAAACGTTACAAGAATCGGACCATCTTGGGCTATAAGACCTTGGCCGTGGGACTCATCAACATGGCAGAGGTGATGCAGCATC CTAATGAAGGCGCACTGGTGCTTGGCCTACACAGCAACGTGAAGGATGTCTCTGTGCCTGTGGCAGAAATAAAGATCTACTCCCTGTCCA GCCAACCCATTGACCATGAAGGAATCAAATCCAAGCTTTCTGATCGTTCTCCTGATATTGACAATTATTCTGAGGAAGAGGAAGAGAGTT TCTCATCAGAACAGGAAGGCAGTGATGATCCATTGCATGGGCAGGACTTGTTCTACGAAGACGAAGATCTCCGGAAAGTGAAGAAGACCC GGAGGAAACTAACCTCAACCTCTGCCATCACAAGGCAACCTAACATCAAACAGAAGTTTGTGGCCCTCCTGAAGCGGTTTAAAGTTTCAG ATGAGGTGGGCTTTGGGCTGGAGCATGTGTCCCGCGAGCAGATCCGGGAAGTGGAAGAGGACTTGGATGAATTGTATGACAGTCTGGAGA TGTACAACCCCAGCGACAGTGGCCCTGAGATGGAGGAGACAGAAAGCATCCTCAGCACGCCAAAGCCCAAGCTCAAGCCTTTCTTTGAGG GGATGTCGCAGTCCAGCTCCCAGACGGAGATTGGCAGCCTCAACAGCAAAGGCAGCCTCGGAAAAGACACCACCAGCCCTATGGAATTGG CTGCTCTAGAAAAAATTAAATCTACTTGGATTAAAAACCAAGATGACAGCTTGACTGAAACAGACACTCTGGAAATCACTGACCAGGACA TGTTTGGAGATGCCAGCACGAGTCTGGTTGTGCCGGAGAAAGTCAAAACTCCCATGAAGTCCAGTAAAACGGATCTCCAGGGCTCTGCCT CCCCCAGCAAAGTGGAGGGGGTGCACACACCCCGGCAGAAGAGGAGCACGCCCCTGAAGGAGCGGCAGCTCTCCAAGCCCCTAAGTGAGA GGACCAACAGTTCCGACAGCGAGCGCTCCCCAGATCTGGGCCACAGCACGCAGATTCCAAGAAAGGTGGTGTATGACCAGCTCAATCAGA TCCTGGTGTCAGATGCAGCCCTCCCAGAAAATGTCATTCTGGTGAACACCACTGACTGGCAGGGCCAGTATGTGGCTGAGCTGCTCCAGG ACCAGCGGAAGCCTGTGGTGTGCACCTGCTCCACCGTGGAGGTCCAGGCCGTGCTGTCCGCCCTGCTCACCCGGATCCAGCGCTACTGCA ACTGCAACTCTTCCATGCCGAGGCCAGTGAAGGTGGCTGCTGTGGGAGGCCAGAGCTACCTGAGCTCCATCCTCAGGTTCTTTGTCAAGT CCCTGGCCAACAAGACCTCCGACTGGCTTGGCTACATGCGCTTCCTCATCATCCCCCTCGGTTCTCACCCTGTGGCCAAATACTTGGGGT CAGTCGACAGTAAATACAGTAGTTCCTTCCTGGATTCTGGTTGGAGAGATCTGTTCAGTCGCTCGGAGCCACCAGTGTCAGAGCAACTGG ACGTGGCAGGGCGGGTGATGCAGTACGTCAACGGGGCAGCCACGACACACCAGCTTCCCGTGGCCGAAGCCATGCTGACTTGCCGGCATA AGTTCCCTGATGAAGACTCCTATCAGAAGTTTATTCCCTTCATTGGCGTGGTGAAGGTGGGTCTGGTTGAAGACTCTCCCTCCACAGCAG GCGATGGGGACGATTCTCCTGTGGTCAGCCTTACTGTGCCCTCCACATCACCACCCTCCAGCTCGGGCCTGAGCCGAGACGCCACGGCCA CCCCTCCCTCCTCCCCATCTATGAGCAGCGCCCTGGCCATCGTGGGGAGCCCTAATAGCCCATATGGGGACGTGATTGGCCTCCAGGTGG ACTACTGGCTGGGCCACCCCGGGGAGCGGAGGAGGGAAGGCGACAAGAGGGACGCCAGCTCGAAGAACACCCTCAAGAGTGTCTTCCGCT CAGTGCAGGTGTCCCGCCTGCCCCATAGTGGGGAGGCCCAGCTTTCTGGCACCATGGCCATGACTGTGGTCACCAAAGAAAAGAACAAGA AAGTTCCCACCATCTTCCTGAGCAAGAAACCCCGAGAAAAGGAGGTGGATTCTAAGAGCCAGGTCATTGAAGGCATCAGCCGCCTCATCT GCTCAGCCAAGCAGCAGCAGACTATGCTGAGAGTGTCCATCGATGGGGTCGAGTGGAGTGACATCAAGTTCTTCCAGCTGGCAGCCCAGT GGCCCACCCATGTCAAGCACTTTCCAGTGGGACTCTTCAGTGGCAGCAAGGCCACCTGAGGCCCTGTCTCCCAGCCACTTTCCCTCCTGG CACTGCCACCAGCCTCACCGCCTGCGGGCAGGGGGAGGCCAGCAGGCCCGGGCCCAGCACCCCTTCCCTGGCACCAGGGTCTGCCTCTCA CTCGCCCAGGTCCCGAAGGACACTGCCACAGGGACGCCTTCCCTCCCCTCCCCTCCAGCCCACCCCTGCACAGCCCCTCCTCCTTCCCGC TTTTCCCCTTCTCCCTCCTGCTCCAGGCCCAAGGCGTGTTGGTTTTGCCTTCTGGTGCCCATAGTCCCCTGGACTGAGTCCCCCAGGCCT TCCTTCACCCGACTTCCAAACTCTTCCTTGTGGTATCAGTTTCCTTCTCGGAAATGAGAAAGCTGGAATCCTGGTCCCCAGCAGGAGAGC CTAGTCCTCCCCCAGCCCCTCCAGCCACCAGGGTGTCCTCTAGGATGCAGCTGCCAGATCCACTCACTCTGCTGCCTCCAGCAGGACCCA AGGCCACTTTCAACTCTTATGGGGTTCTCCACCTGCCCCAGAGCTTCTCAAGGGAGGGTAAGGGGGCACCCTGAGCCCACAGGACCCCTA CTTCACAGCTCACAGGGGCAGGAGGCAGCTCCCCTGCCTCCAGGACCCTGTTGCTATGGTGACACAGCGTTTCTAGGACAGAGGGGCCTC CCAGTCTCCCCCCACCACCCGTGCACGACTTCCTCACCACCCCCAGGTTCCCTGCAGATGTCGTGTGTGTCCTGAGTGTTTCTTTGGTTC TTTGCACGCCAAGTCTCTTGGTTGTACCATGTGACACACCCTGTGCACTGGTCGCTGTCTTCGTGGCTTCCACCCTTGTTAATGATGCTC CTGCCTCTGCCTCCCAGCCCCTCACCCAGCACAGCTCTGCCTGGACTTGGAGAGATGGGAGGCAGACCCCCACCACCATACATGCTGTCT GTGGCCCCTCAGACATTCTGTTTCATCTCCCATTCATCTCCCTCCTCCCACCGTGTCAGTTTTTCTGCCTTTCCCTGCTCTGTTCTTCCC CCTCCTTAGGCCCCAGCCTGGGCCCAGACCCATCCTCCCAGCCAGGTTTCCCTCCAGCAGGCTCCTTCCCTCCCTGTCACCTCCCTCTCA CCAACCCGGGGTCTGAGCCCCTCATTCCTGACCGTCCGTGTTCTCAGGAGTGGTTGAGGACACAGGGCCCCAGCCCAGCCCTCTGCACCC CCCAGCCCGGCCATCTGCGCCCCACAGCCCCTTTGGAGCTTTTCTCTTGTCCTCTCACTCCTTCCCAGAAGTTTTTGCACAGAACTTCAT TTTGAAAGTGTTTTTCTCATTCTCCATACCTCCCCCAAGCTCTCCTCCAGCCCTTCCCAGGGCTCAGCCCTGCTGTCCTGAGCGTCTCCT >In-frame_ENST00000450466_ENST00000320580_TCGA-UF-A71B-01A_TMEM241_chr18_20889644_-_PACS1_chr11_65960957_length(amino acids)=1000AA_start in transcript=476_stop in transcript=3478 MIPDVISALLLLAAAGCLPFNDSQFNPDGYFWAIIHLLCVGAYKILQKSQKPSALSDIDQQYLNYIFSVVLLAFASHPTGDLFSVLDFPF LYFYRFHGSCCASGFLGFFLMFSTVKLKNLLAPGQCAAWIFFAKIITAGLSILLFDAILTSATTGWLFSLTLKKLVMLKEMDKDLNSVVI AVKLQGSKRILRSNEIVLPASGLVETELQLTFSLQYPHFLKRDANKLQIMLQRRKRYKNRTILGYKTLAVGLINMAEVMQHPNEGALVLG LHSNVKDVSVPVAEIKIYSLSSQPIDHEGIKSKLSDRSPDIDNYSEEEEESFSSEQEGSDDPLHGQDLFYEDEDLRKVKKTRRKLTSTSA ITRQPNIKQKFVALLKRFKVSDEVGFGLEHVSREQIREVEEDLDELYDSLEMYNPSDSGPEMEETESILSTPKPKLKPFFEGMSQSSSQT EIGSLNSKGSLGKDTTSPMELAALEKIKSTWIKNQDDSLTETDTLEITDQDMFGDASTSLVVPEKVKTPMKSSKTDLQGSASPSKVEGVH TPRQKRSTPLKERQLSKPLSERTNSSDSERSPDLGHSTQIPRKVVYDQLNQILVSDAALPENVILVNTTDWQGQYVAELLQDQRKPVVCT CSTVEVQAVLSALLTRIQRYCNCNSSMPRPVKVAAVGGQSYLSSILRFFVKSLANKTSDWLGYMRFLIIPLGSHPVAKYLGSVDSKYSSS FLDSGWRDLFSRSEPPVSEQLDVAGRVMQYVNGAATTHQLPVAEAMLTCRHKFPDEDSYQKFIPFIGVVKVGLVEDSPSTAGDGDDSPVV SLTVPSTSPPSSSGLSRDATATPPSSPSMSSALAIVGSPNSPYGDVIGLQVDYWLGHPGERRREGDKRDASSKNTLKSVFRSVQVSRLPH SGEAQLSGTMAMTVVTKEKNKKVPTIFLSKKPREKEVDSKSQVIEGISRLICSAKQQQTMLRVSIDGVEWSDIKFFQLAAQWPTHVKHFP -------------------------------------------------------------- >In-frame_ENST00000383233_ENST00000320580_TCGA-UF-A71B-01A_TMEM241_chr18_20889644_-_PACS1_chr11_65960957_length(transcript)=4886nt_BP=883nt CCAGGGGATTTGGGCAGGCACCGTGGATCCCCGAGAAGGGGACGAGTTGACAGATGTGCGTGAGGAGGTCTCTGGTCGGCCTCACCTTTT GTACCTGCTACCTGGCTTCTTACCTCACGAACAAGTATGTGCTGTCTGTCTTGAAATTTACCTACCCTACATTATTCCAAGGGTGGCAGA CGCTCATTGGTGGACTTTTGCTTCATGTGTCCTGGAAACTGGGCTGGGTAGAGATCAACAGCAGTTCAAGATCTCATGTTCTTGTGTGGC TTCCTGCTTCAGTGCTGTTTGTGGGTATAATCTATGCTGGGTCCAGAGCATTGTCCAGACTGGCCATTCCTGTGTTTCTCACTTTGCATA ATGTAGCTGAAGTTATCATCTGTGGGTACCAGAAGTGTTTTCAGAAAGAGAAAACATCTCCTGCAAAGATCTGTAGTGCCCTCCTCCTCC TGGCCGCAGCAGGATGCCTTCCCTTCAATGACTCCCAGTTTAATCCAGATGGATATTTTTGGGCTATAATTCACTTACTCTGTGTAGGGG CTTATAAAATTCTACAGAAGTCCCAGAAACCCAGTGCATTAAGTGACATTGACCAGCAATACTTAAACTATATATTCAGTGTGGTGCTCC TGGCATTTGCATCTCATCCCACAGGTGATCTCTTCAGCGTCCTGGACTTCCCATTCCTGTACTTCTACAGATTCCATGGTAGCTGCTGTG CCAGTGGATTTTTGGGATTCTTTCTCATGTTCAGTACAGTGAAGCTAAAAAACCTTCTGGCCCCAGGGCAGTGTGCAGCCTGGATTTTCT TTGCTAAGATAATCACAGCTGGCTTATCAATATTGCTGTTTGATGCGATCCTGACCAGTGCAACCACGGGATGGCTATTCAGCTTGACCC TGAAGAAACTCGTCATGCTAAAAGAAATGGACAAAGATCTTAACTCAGTGGTCATCGCTGTGAAGCTGCAGGGTTCAAAAAGAATTCTTC GCTCCAACGAGATCGTCCTTCCAGCTAGTGGACTGGTGGAAACAGAGCTCCAATTAACCTTCTCCCTTCAGTACCCTCATTTCCTTAAGC GAGATGCCAACAAGCTGCAGATCATGCTGCAAAGGAGAAAACGTTACAAGAATCGGACCATCTTGGGCTATAAGACCTTGGCCGTGGGAC TCATCAACATGGCAGAGGTGATGCAGCATCCTAATGAAGGCGCACTGGTGCTTGGCCTACACAGCAACGTGAAGGATGTCTCTGTGCCTG TGGCAGAAATAAAGATCTACTCCCTGTCCAGCCAACCCATTGACCATGAAGGAATCAAATCCAAGCTTTCTGATCGTTCTCCTGATATTG ACAATTATTCTGAGGAAGAGGAAGAGAGTTTCTCATCAGAACAGGAAGGCAGTGATGATCCATTGCATGGGCAGGACTTGTTCTACGAAG ACGAAGATCTCCGGAAAGTGAAGAAGACCCGGAGGAAACTAACCTCAACCTCTGCCATCACAAGGCAACCTAACATCAAACAGAAGTTTG TGGCCCTCCTGAAGCGGTTTAAAGTTTCAGATGAGGTGGGCTTTGGGCTGGAGCATGTGTCCCGCGAGCAGATCCGGGAAGTGGAAGAGG ACTTGGATGAATTGTATGACAGTCTGGAGATGTACAACCCCAGCGACAGTGGCCCTGAGATGGAGGAGACAGAAAGCATCCTCAGCACGC CAAAGCCCAAGCTCAAGCCTTTCTTTGAGGGGATGTCGCAGTCCAGCTCCCAGACGGAGATTGGCAGCCTCAACAGCAAAGGCAGCCTCG GAAAAGACACCACCAGCCCTATGGAATTGGCTGCTCTAGAAAAAATTAAATCTACTTGGATTAAAAACCAAGATGACAGCTTGACTGAAA CAGACACTCTGGAAATCACTGACCAGGACATGTTTGGAGATGCCAGCACGAGTCTGGTTGTGCCGGAGAAAGTCAAAACTCCCATGAAGT CCAGTAAAACGGATCTCCAGGGCTCTGCCTCCCCCAGCAAAGTGGAGGGGGTGCACACACCCCGGCAGAAGAGGAGCACGCCCCTGAAGG AGCGGCAGCTCTCCAAGCCCCTAAGTGAGAGGACCAACAGTTCCGACAGCGAGCGCTCCCCAGATCTGGGCCACAGCACGCAGATTCCAA GAAAGGTGGTGTATGACCAGCTCAATCAGATCCTGGTGTCAGATGCAGCCCTCCCAGAAAATGTCATTCTGGTGAACACCACTGACTGGC AGGGCCAGTATGTGGCTGAGCTGCTCCAGGACCAGCGGAAGCCTGTGGTGTGCACCTGCTCCACCGTGGAGGTCCAGGCCGTGCTGTCCG CCCTGCTCACCCGGATCCAGCGCTACTGCAACTGCAACTCTTCCATGCCGAGGCCAGTGAAGGTGGCTGCTGTGGGAGGCCAGAGCTACC TGAGCTCCATCCTCAGGTTCTTTGTCAAGTCCCTGGCCAACAAGACCTCCGACTGGCTTGGCTACATGCGCTTCCTCATCATCCCCCTCG GTTCTCACCCTGTGGCCAAATACTTGGGGTCAGTCGACAGTAAATACAGTAGTTCCTTCCTGGATTCTGGTTGGAGAGATCTGTTCAGTC GCTCGGAGCCACCAGTGTCAGAGCAACTGGACGTGGCAGGGCGGGTGATGCAGTACGTCAACGGGGCAGCCACGACACACCAGCTTCCCG TGGCCGAAGCCATGCTGACTTGCCGGCATAAGTTCCCTGATGAAGACTCCTATCAGAAGTTTATTCCCTTCATTGGCGTGGTGAAGGTGG GTCTGGTTGAAGACTCTCCCTCCACAGCAGGCGATGGGGACGATTCTCCTGTGGTCAGCCTTACTGTGCCCTCCACATCACCACCCTCCA GCTCGGGCCTGAGCCGAGACGCCACGGCCACCCCTCCCTCCTCCCCATCTATGAGCAGCGCCCTGGCCATCGTGGGGAGCCCTAATAGCC CATATGGGGACGTGATTGGCCTCCAGGTGGACTACTGGCTGGGCCACCCCGGGGAGCGGAGGAGGGAAGGCGACAAGAGGGACGCCAGCT CGAAGAACACCCTCAAGAGTGTCTTCCGCTCAGTGCAGGTGTCCCGCCTGCCCCATAGTGGGGAGGCCCAGCTTTCTGGCACCATGGCCA TGACTGTGGTCACCAAAGAAAAGAACAAGAAAGTTCCCACCATCTTCCTGAGCAAGAAACCCCGAGAAAAGGAGGTGGATTCTAAGAGCC AGGTCATTGAAGGCATCAGCCGCCTCATCTGCTCAGCCAAGCAGCAGCAGACTATGCTGAGAGTGTCCATCGATGGGGTCGAGTGGAGTG ACATCAAGTTCTTCCAGCTGGCAGCCCAGTGGCCCACCCATGTCAAGCACTTTCCAGTGGGACTCTTCAGTGGCAGCAAGGCCACCTGAG GCCCTGTCTCCCAGCCACTTTCCCTCCTGGCACTGCCACCAGCCTCACCGCCTGCGGGCAGGGGGAGGCCAGCAGGCCCGGGCCCAGCAC CCCTTCCCTGGCACCAGGGTCTGCCTCTCACTCGCCCAGGTCCCGAAGGACACTGCCACAGGGACGCCTTCCCTCCCCTCCCCTCCAGCC CACCCCTGCACAGCCCCTCCTCCTTCCCGCTTTTCCCCTTCTCCCTCCTGCTCCAGGCCCAAGGCGTGTTGGTTTTGCCTTCTGGTGCCC ATAGTCCCCTGGACTGAGTCCCCCAGGCCTTCCTTCACCCGACTTCCAAACTCTTCCTTGTGGTATCAGTTTCCTTCTCGGAAATGAGAA AGCTGGAATCCTGGTCCCCAGCAGGAGAGCCTAGTCCTCCCCCAGCCCCTCCAGCCACCAGGGTGTCCTCTAGGATGCAGCTGCCAGATC CACTCACTCTGCTGCCTCCAGCAGGACCCAAGGCCACTTTCAACTCTTATGGGGTTCTCCACCTGCCCCAGAGCTTCTCAAGGGAGGGTA AGGGGGCACCCTGAGCCCACAGGACCCCTACTTCACAGCTCACAGGGGCAGGAGGCAGCTCCCCTGCCTCCAGGACCCTGTTGCTATGGT GACACAGCGTTTCTAGGACAGAGGGGCCTCCCAGTCTCCCCCCACCACCCGTGCACGACTTCCTCACCACCCCCAGGTTCCCTGCAGATG TCGTGTGTGTCCTGAGTGTTTCTTTGGTTCTTTGCACGCCAAGTCTCTTGGTTGTACCATGTGACACACCCTGTGCACTGGTCGCTGTCT TCGTGGCTTCCACCCTTGTTAATGATGCTCCTGCCTCTGCCTCCCAGCCCCTCACCCAGCACAGCTCTGCCTGGACTTGGAGAGATGGGA GGCAGACCCCCACCACCATACATGCTGTCTGTGGCCCCTCAGACATTCTGTTTCATCTCCCATTCATCTCCCTCCTCCCACCGTGTCAGT TTTTCTGCCTTTCCCTGCTCTGTTCTTCCCCCTCCTTAGGCCCCAGCCTGGGCCCAGACCCATCCTCCCAGCCAGGTTTCCCTCCAGCAG GCTCCTTCCCTCCCTGTCACCTCCCTCTCACCAACCCGGGGTCTGAGCCCCTCATTCCTGACCGTCCGTGTTCTCAGGAGTGGTTGAGGA CACAGGGCCCCAGCCCAGCCCTCTGCACCCCCCAGCCCGGCCATCTGCGCCCCACAGCCCCTTTGGAGCTTTTCTCTTGTCCTCTCACTC CTTCCCAGAAGTTTTTGCACAGAACTTCATTTTGAAAGTGTTTTTCTCATTCTCCATACCTCCCCCAAGCTCTCCTCCAGCCCTTCCCAG GGCTCAGCCCTGCTGTCCTGAGCGTCTCCTGGGCCAGAGAGAGGAGATGGGGGTGGGAGGGACTGAGTTGATGTTGGGTTTTTCATTCAA >In-frame_ENST00000383233_ENST00000320580_TCGA-UF-A71B-01A_TMEM241_chr18_20889644_-_PACS1_chr11_65960957_length(amino acids)=1121AA_start in transcript=53_stop in transcript=3418 MCVRRSLVGLTFCTCYLASYLTNKYVLSVLKFTYPTLFQGWQTLIGGLLLHVSWKLGWVEINSSSRSHVLVWLPASVLFVGIIYAGSRAL SRLAIPVFLTLHNVAEVIICGYQKCFQKEKTSPAKICSALLLLAAAGCLPFNDSQFNPDGYFWAIIHLLCVGAYKILQKSQKPSALSDID QQYLNYIFSVVLLAFASHPTGDLFSVLDFPFLYFYRFHGSCCASGFLGFFLMFSTVKLKNLLAPGQCAAWIFFAKIITAGLSILLFDAIL TSATTGWLFSLTLKKLVMLKEMDKDLNSVVIAVKLQGSKRILRSNEIVLPASGLVETELQLTFSLQYPHFLKRDANKLQIMLQRRKRYKN RTILGYKTLAVGLINMAEVMQHPNEGALVLGLHSNVKDVSVPVAEIKIYSLSSQPIDHEGIKSKLSDRSPDIDNYSEEEEESFSSEQEGS DDPLHGQDLFYEDEDLRKVKKTRRKLTSTSAITRQPNIKQKFVALLKRFKVSDEVGFGLEHVSREQIREVEEDLDELYDSLEMYNPSDSG PEMEETESILSTPKPKLKPFFEGMSQSSSQTEIGSLNSKGSLGKDTTSPMELAALEKIKSTWIKNQDDSLTETDTLEITDQDMFGDASTS LVVPEKVKTPMKSSKTDLQGSASPSKVEGVHTPRQKRSTPLKERQLSKPLSERTNSSDSERSPDLGHSTQIPRKVVYDQLNQILVSDAAL PENVILVNTTDWQGQYVAELLQDQRKPVVCTCSTVEVQAVLSALLTRIQRYCNCNSSMPRPVKVAAVGGQSYLSSILRFFVKSLANKTSD WLGYMRFLIIPLGSHPVAKYLGSVDSKYSSSFLDSGWRDLFSRSEPPVSEQLDVAGRVMQYVNGAATTHQLPVAEAMLTCRHKFPDEDSY QKFIPFIGVVKVGLVEDSPSTAGDGDDSPVVSLTVPSTSPPSSSGLSRDATATPPSSPSMSSALAIVGSPNSPYGDVIGLQVDYWLGHPG ERRREGDKRDASSKNTLKSVFRSVQVSRLPHSGEAQLSGTMAMTVVTKEKNKKVPTIFLSKKPREKEVDSKSQVIEGISRLICSAKQQQT -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for TMEM241-PACS1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for TMEM241-PACS1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for TMEM241-PACS1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PACS1 | C3714756 | Intellectual Disability | 2 | GENOMICS_ENGLAND |
Tgene | PACS1 | C0005586 | Bipolar Disorder | 1 | CTD_human |
Tgene | PACS1 | C0005587 | Depression, Bipolar | 1 | CTD_human |
Tgene | PACS1 | C0013146 | Drug abuse | 1 | CTD_human |
Tgene | PACS1 | C0013170 | Drug habituation | 1 | CTD_human |
Tgene | PACS1 | C0013222 | Drug Use Disorders | 1 | CTD_human |
Tgene | PACS1 | C0024713 | Manic Disorder | 1 | CTD_human |
Tgene | PACS1 | C0028754 | Obesity | 1 | CTD_human |
Tgene | PACS1 | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human |
Tgene | PACS1 | C0038580 | Substance Dependence | 1 | CTD_human |
Tgene | PACS1 | C0038586 | Substance Use Disorders | 1 | CTD_human |
Tgene | PACS1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Tgene | PACS1 | C0338831 | Manic | 1 | CTD_human |
Tgene | PACS1 | C0740858 | Substance abuse problem | 1 | CTD_human |
Tgene | PACS1 | C1510472 | Drug Dependence | 1 | CTD_human |
Tgene | PACS1 | C3554343 | MENTAL RETARDATION, AUTOSOMAL DOMINANT 17 | 1 | GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Tgene | PACS1 | C4316881 | Prescription Drug Abuse | 1 | CTD_human |