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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMEM63A-FCGR2A (FusionGDB2 ID:91560)

Fusion Gene Summary for TMEM63A-FCGR2A

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM63A-FCGR2A
Fusion gene ID: 91560
HgeneTgene
Gene symbol

TMEM63A

FCGR2A

Gene ID

9725

2212

Gene nametransmembrane protein 63AFc fragment of IgG receptor IIa
SynonymsHLD19|KIAA0792CD32|CD32A|CDw32|FCG2|FCGR2|FCGR2A1|FcGR|IGFR2
Cytomap

1q42.12

1q23.3

Type of geneprotein-codingprotein-coding
DescriptionCSC1-like protein 1low affinity immunoglobulin gamma Fc region receptor II-aFc fragment of IgG, low affinity IIa, receptor (CD32)Fc gamma receptor RIIa3Immunoglobulin G Fc receptor IIfc-gamma-RIIafcRII-aigG Fc receptor II-a
Modification date2020031320200313
UniProtAcc.

P12318

Ensembl transtripts involved in fusion geneENST00000366835, ENST00000474478, 
ENST00000537914, 		ENST00000367972, 
ENST00000271450, ENST00000486608, 
Fusion gene scores* DoF score11 X 11 X 6=7262 X 2 X 2=8
# samples 112
** MAII scorelog2(11/726*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: TMEM63A [Title/Abstract] AND FCGR2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMEM63A(226059687)-FCGR2A(161487765), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TMEM63A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FCGR2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-FJ-A3ZE-01ATMEM63Achr1

226059687

-FCGR2Achr1

161487765

+
ChimerDB4BLCATCGA-FJ-A3ZE-01ATMEM63Achr1

226059687

-FCGR2Achr1

161487765

+


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Fusion Gene ORF analysis for TMEM63A-FCGR2A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000366835ENST00000367972TMEM63Achr1

226059687

-FCGR2Achr1

161487765

+
In-frameENST00000366835ENST00000271450TMEM63Achr1

226059687

-FCGR2Achr1

161487765

+
5CDS-3UTRENST00000366835ENST00000486608TMEM63Achr1

226059687

-FCGR2Achr1

161487765

+
intron-3CDSENST00000474478ENST00000367972TMEM63Achr1

226059687

-FCGR2Achr1

161487765

+
intron-3CDSENST00000474478ENST00000271450TMEM63Achr1

226059687

-FCGR2Achr1

161487765

+
intron-3UTRENST00000474478ENST00000486608TMEM63Achr1

226059687

-FCGR2Achr1

161487765

+
intron-3CDSENST00000537914ENST00000367972TMEM63Achr1

226059687

-FCGR2Achr1

161487765

+
intron-3CDSENST00000537914ENST00000271450TMEM63Achr1

226059687

-FCGR2Achr1

161487765

+
intron-3UTRENST00000537914ENST00000486608TMEM63Achr1

226059687

-FCGR2Achr1

161487765

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000366835TMEM63Achr1226059687-ENST00000271450FCGR2Achr1161487765+2198604271777168

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366835ENST00000271450TMEM63Achr1226059687-FCGR2Achr1161487765+0.0029637050.99703634

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Fusion Genomic Features for TMEM63A-FCGR2A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TMEM63Achr1226059686-FCGR2Achr1161487764+5.52E-081
TMEM63Achr1226059686-FCGR2Achr1161487764+5.52E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM63A-FCGR2A


check button Go to

FGviewer for the breakpoints of chr1:226059687-chr1:161487765

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FCGR2A

P12318

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. {ECO:0000269|PubMed:19011614}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM63Achr1:226059687chr1:161487765ENST00000366835-52550_70111.01248.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM63Achr1:226059687chr1:161487765ENST00000366835-525146_166111.01248.0TransmembraneHelical
HgeneTMEM63Achr1:226059687chr1:161487765ENST00000366835-525191_211111.01248.0TransmembraneHelical
HgeneTMEM63Achr1:226059687chr1:161487765ENST00000366835-525423_443111.01248.0TransmembraneHelical
HgeneTMEM63Achr1:226059687chr1:161487765ENST00000366835-525462_482111.01248.0TransmembraneHelical
HgeneTMEM63Achr1:226059687chr1:161487765ENST00000366835-525508_528111.01248.0TransmembraneHelical
HgeneTMEM63Achr1:226059687chr1:161487765ENST00000366835-525553_573111.01248.0TransmembraneHelical
HgeneTMEM63Achr1:226059687chr1:161487765ENST00000366835-525620_640111.01248.0TransmembraneHelical
HgeneTMEM63Achr1:226059687chr1:161487765ENST00000366835-525665_685111.01248.0TransmembraneHelical
HgeneTMEM63Achr1:226059687chr1:161487765ENST00000366835-525698_718111.01248.0TransmembraneHelical
TgeneFCGR2Achr1:226059687chr1:161487765ENST0000027145057122_204260.0318.0DomainNote=Ig-like C2-type 2
TgeneFCGR2Achr1:226059687chr1:161487765ENST000002714505739_118260.0318.0DomainNote=Ig-like C2-type 1
TgeneFCGR2Achr1:226059687chr1:161487765ENST0000036797257122_204259.0317.0DomainNote=Ig-like C2-type 2
TgeneFCGR2Achr1:226059687chr1:161487765ENST000003679725739_118259.0317.0DomainNote=Ig-like C2-type 1
TgeneFCGR2Achr1:226059687chr1:161487765ENST0000027145057241_317260.0318.0Topological domainCytoplasmic
TgeneFCGR2Achr1:226059687chr1:161487765ENST000002714505734_217260.0318.0Topological domainExtracellular
TgeneFCGR2Achr1:226059687chr1:161487765ENST0000036797257241_317259.0317.0Topological domainCytoplasmic
TgeneFCGR2Achr1:226059687chr1:161487765ENST000003679725734_217259.0317.0Topological domainExtracellular
TgeneFCGR2Achr1:226059687chr1:161487765ENST0000027145057218_240260.0318.0TransmembraneHelical
TgeneFCGR2Achr1:226059687chr1:161487765ENST0000036797257218_240259.0317.0TransmembraneHelical


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Fusion Gene Sequence for TMEM63A-FCGR2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000366835_ENST00000271450_TCGA-FJ-A3ZE-01A_TMEM63A_chr1_226059687_-_FCGR2A_chr1_161487765_length(transcript)=2198nt_BP=604nt
GTAACTTTTAAGTGGTCGGAACACGCCCCGCGCTGCTGGGTCCCGCCAGACACGCCGCCGCCGCAGGAAAGTCTACAGTTTGGTACCCCA
GGACTCGCTGGTCAGGAAAGCCCTGCAGGACATGAGTGTTAGGCCCGACGCCTGGCCCTTGGCAGCTTGGGAGGTGGCTGGGGCTGCTTT
TGCCTTTGCCAGAGACAGCTCCAACTGAGGACCTCTCCAACGGGCCCATCCACAGTCCTTCCTTCCCCTAGTGTCTGGGAAGACAGGCGC
GATGATGGACTCCCCGTTCCTGGAGCTGTGGCAGTCCAAGGCAGTGTCCATCAGGGAGCAGCTGGGACTCGGGGACCGGCCCAACGACTC
CTATTGCTACAACTCGGCCAAAAACAGCACCGTGCTCCAGGGGGTCACCTTTGGTGGCATCCCCACTGTCCTGCTCATAGACGTCAGCTG
CTTCCTGTTCTTAATCTTGGTGTTTTCTATTATAAGAAGAAGATTCTGGGACTATGGCCGCATTGCCCTGGTGTCAGAAGCAGACAGCGA
GTCCAGATTTCAGAGATTGTCATCGACTTCCTCCTCAGGTCAACAAGACTTTGAAAATGAGCTGCCACCTGGACGTCAAATGATTGCCAT
CAGAAAGAGACAACTTGAAGAAACCAACAATGACTATGAAACAGCTGACGGCGGCTACATGACTCTGAACCCCAGGGCACCTACTGACGA
TGATAAAAACATCTACCTGACTCTTCCTCCCAACGACCATGTCAACAGTAATAACTAAAGAGTAACGTTATGCCATGTGGTCATACTCTC
AGCTTGCTGAGTGGATGACAAAAAGAGGGGAATTGTTAAAGGAAAATTTAAATGGAGACTGGAAAAATCCTGAGCAAACAAAACCACCTG
GCCCTTAGAAATAGCTTTAACTTTGCTTAAACTACAAACACAAGCAAAACTTCACGGGGTCATACTACATACAAGCATAAGCAAAACTTA
ACTTGGATCATTTCTGGTAAATGCTTATGTTAGAAATAAGACAACCCCAGCCAATCACAAGCAGCCTACTAACATATAATTAGGTGACTA
GGGACTTTCTAAGAAGATACCTACCCCCAAAAAACAATTATGTAATTGAAAACCAACCGATTGCCTTTATTTTGCTTCCACATTTTCCCA
ATAAATACTTGCCTGTGACATTTTGCCACTGGAACACTAAACTTCATGAATTGCGCCTCAGATTTTTCCTTTAACATCTTTTTTTTTTTT
GACAGAGTCTCAATCTGTTACCCAGGCTGGAGTGCAGTGGTGCTATCTTGGCTCACTGCAAACCCGCCTCCCAGGTTTAAGCGATTCTCA
TGCCTCAGCCTCCCAGTAGCTGGGATTAGAGGCATGTGCCATCATACCCAGCTAATTTTTGTATTTTTTATTTTTTTTTTTTAGTAGAGA
CAGGGTTTCGCAATGTTGGCCAGGCCGATCTCGAACTTCTGGCCTCTAGCGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATGACCA
GCATCAGCCCCAATGTCCAGCCTCTTTAACATCTTCTTTCCTATGCCCTCTCTGTGGATCCCTACTGCTGGTTTCTGCCTTCTCCATGCT
GAGAACAAAATCACCTATTCACTGCTTATGCAGTCGGAAGCTCCAGAAGAACAAAGAGCCCAATTACCAGAACCACATTAAGTCTCCATT
GTTTTGCCTTGGGATTTGAGAAGAGAATTAGAGAGGTGAGGATCTGGTATTTCCTGGACTAAATTCCCCTTGGGGAAGACGAAGGGATGC
TGCAGTTCCAAAAGAGAAGGACTCTTCCAGAGTCATCTACCTGAGTCCCAAAGCTCCCTGTCCTGAAAGCCACAGACAATATGGTCCCAA
ATGACTGACTGCACCTTCTGTGCCTCAGCCGTTCTTGACATCAAGAATCTTCTGTTCCACATCCACACAGCCAATACAATTAGTCAAACC
ACTGTTATTAACAGATGTAGCAACATGAGAAACGCTTATGTTACAGGTTACATGAGAGCAATCATGTAAGTCTATATGACTTCAGAAATG
TTAAAATAGACTAACCTCTAACAACAAATTAAAAGTGATTGTTTCAAGGTGATGCAATTATTGATGACCTATTTTATTTTTCTATAATGA

>In-frame_ENST00000366835_ENST00000271450_TCGA-FJ-A3ZE-01A_TMEM63A_chr1_226059687_-_FCGR2A_chr1_161487765_length(amino acids)=168AA_start in transcript=271_stop in transcript=777
MMDSPFLELWQSKAVSIREQLGLGDRPNDSYCYNSAKNSTVLQGVTFGGIPTVLLIDVSCFLFLILVFSIIRRRFWDYGRIALVSEADSE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TMEM63A-FCGR2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMEM63A-FCGR2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFCGR2AP12318DB00002CetuximabBiotechApproved
TgeneFCGR2AP12318DB00002CetuximabBiotechApproved
TgeneFCGR2AP12318DB00002CetuximabBiotechApproved
TgeneFCGR2AP12318DB00002CetuximabBiotechApproved
TgeneFCGR2AP12318DB00002CetuximabBiotechApproved
TgeneFCGR2AP12318DB00054AbciximabBiotechApproved
TgeneFCGR2AP12318DB00054AbciximabBiotechApproved
TgeneFCGR2AP12318DB00054AbciximabBiotechApproved
TgeneFCGR2AP12318DB00054AbciximabBiotechApproved
TgeneFCGR2AP12318DB00054AbciximabBiotechApproved
TgeneFCGR2AP12318DB00005EtanerceptLigandBiotechApproved|Investigational
TgeneFCGR2AP12318DB00005EtanerceptLigandBiotechApproved|Investigational
TgeneFCGR2AP12318DB00005EtanerceptLigandBiotechApproved|Investigational
TgeneFCGR2AP12318DB00005EtanerceptLigandBiotechApproved|Investigational
TgeneFCGR2AP12318DB00005EtanerceptLigandBiotechApproved|Investigational
TgeneFCGR2AP12318DB00028Human immunoglobulin GAntagonistBiotechApproved|Investigational
TgeneFCGR2AP12318DB00028Human immunoglobulin GAntagonistBiotechApproved|Investigational
TgeneFCGR2AP12318DB00028Human immunoglobulin GAntagonistBiotechApproved|Investigational
TgeneFCGR2AP12318DB00028Human immunoglobulin GAntagonistBiotechApproved|Investigational
TgeneFCGR2AP12318DB00028Human immunoglobulin GAntagonistBiotechApproved|Investigational
TgeneFCGR2AP12318DB00087AlemtuzumabBiotechApproved|Investigational
TgeneFCGR2AP12318DB00087AlemtuzumabBiotechApproved|Investigational
TgeneFCGR2AP12318DB00087AlemtuzumabBiotechApproved|Investigational
TgeneFCGR2AP12318DB00087AlemtuzumabBiotechApproved|Investigational
TgeneFCGR2AP12318DB00087AlemtuzumabBiotechApproved|Investigational
TgeneFCGR2AP12318DB00112BevacizumabBiotechApproved|Investigational
TgeneFCGR2AP12318DB00112BevacizumabBiotechApproved|Investigational
TgeneFCGR2AP12318DB00112BevacizumabBiotechApproved|Investigational
TgeneFCGR2AP12318DB00112BevacizumabBiotechApproved|Investigational
TgeneFCGR2AP12318DB00112BevacizumabBiotechApproved|Investigational
TgeneFCGR2AP12318DB11767SarilumabUnknownBiotechApproved|Investigational
TgeneFCGR2AP12318DB11767SarilumabUnknownBiotechApproved|Investigational
TgeneFCGR2AP12318DB11767SarilumabUnknownBiotechApproved|Investigational
TgeneFCGR2AP12318DB11767SarilumabUnknownBiotechApproved|Investigational
TgeneFCGR2AP12318DB11767SarilumabUnknownBiotechApproved|Investigational
TgeneFCGR2AP12318DB06607CatumaxomabAgonistBiotechApproved|Investigational|Withdrawn
TgeneFCGR2AP12318DB06607CatumaxomabAgonistBiotechApproved|Investigational|Withdrawn
TgeneFCGR2AP12318DB06607CatumaxomabAgonistBiotechApproved|Investigational|Withdrawn
TgeneFCGR2AP12318DB06607CatumaxomabAgonistBiotechApproved|Investigational|Withdrawn
TgeneFCGR2AP12318DB06607CatumaxomabAgonistBiotechApproved|Investigational|Withdrawn

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Related Diseases for TMEM63A-FCGR2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMEM63AC0024623Malignant neoplasm of stomach1CTD_human
HgeneTMEM63AC0038356Stomach Neoplasms1CTD_human
HgeneTMEM63AC0235874Disease Exacerbation1CTD_human
HgeneTMEM63AC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneFCGR2AC0003873Rheumatoid Arthritis2CTD_human
TgeneFCGR2AC0009324Ulcerative Colitis2CTD_human
TgeneFCGR2AC0026691Mucocutaneous Lymph Node Syndrome2CTD_human
TgeneFCGR2AC0024141Lupus Erythematosus, Systemic1CTD_human
TgeneFCGR2AC0040034Thrombocytopenia1CTD_human
TgeneFCGR2AC0040053Thrombosis1CTD_human
TgeneFCGR2AC0086981Sicca Syndrome1CTD_human
TgeneFCGR2AC0087086Thrombus1CTD_human
TgeneFCGR2AC0242380Libman-Sacks Disease1CTD_human
TgeneFCGR2AC1527336Sjogren's Syndrome1CTD_human