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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMEM87A-CAPN8 (FusionGDB2 ID:91607)

Fusion Gene Summary for TMEM87A-CAPN8

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM87A-CAPN8
Fusion gene ID: 91607
HgeneTgene
Gene symbol

TMEM87A

CAPN8

Gene ID

25963

388743

Gene nametransmembrane protein 87Acalpain 8
Synonyms-nCL-2
Cytomap

15q15.1

1q41

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 87Acalpain-8new calpain 2stomach-specific M-type calpain
Modification date2020031320200313
UniProtAcc.

A6NHC0

Ensembl transtripts involved in fusion geneENST00000389834, ENST00000448392, 
ENST00000307216, ENST00000568432, 
ENST00000366872, ENST00000366873, 
Fusion gene scores* DoF score5 X 5 X 4=10012 X 2 X 4=96
# samples 512
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/96*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TMEM87A [Title/Abstract] AND CAPN8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMEM87A(42525411)-CAPN8(223718212), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TMEM87A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CAPN8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4J9-01ATMEM87Achr15

42525411

-CAPN8chr1

223718212

-


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Fusion Gene ORF analysis for TMEM87A-CAPN8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000389834ENST00000366872TMEM87Achr15

42525411

-CAPN8chr1

223718212

-
5CDS-intronENST00000389834ENST00000366873TMEM87Achr15

42525411

-CAPN8chr1

223718212

-
In-frameENST00000448392ENST00000366872TMEM87Achr15

42525411

-CAPN8chr1

223718212

-
5CDS-intronENST00000448392ENST00000366873TMEM87Achr15

42525411

-CAPN8chr1

223718212

-
intron-3CDSENST00000307216ENST00000366872TMEM87Achr15

42525411

-CAPN8chr1

223718212

-
intron-intronENST00000307216ENST00000366873TMEM87Achr15

42525411

-CAPN8chr1

223718212

-
intron-3CDSENST00000568432ENST00000366872TMEM87Achr15

42525411

-CAPN8chr1

223718212

-
intron-intronENST00000568432ENST00000366873TMEM87Achr15

42525411

-CAPN8chr1

223718212

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000389834TMEM87Achr1542525411-ENST00000366872CAPN8chr1223718212-182213272651605446
ENST00000448392TMEM87Achr1542525411-ENST00000366872CAPN8chr1223718212-153810431641321385

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000389834ENST00000366872TMEM87Achr1542525411-CAPN8chr1223718212-0.001244420.9987556
ENST00000448392ENST00000366872TMEM87Achr1542525411-CAPN8chr1223718212-0.002187730.9978123

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Fusion Genomic Features for TMEM87A-CAPN8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM87A-CAPN8


check button Go to

FGviewer for the breakpoints of chr15:42525411-chr1:223718212

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CAPN8

A6NHC0

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000389834-112022_225354.0556.0Topological domainLumenal
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000389834-1120247_257354.0556.0Topological domainCytoplasmic
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000389834-1120279_305354.0556.0Topological domainLumenal
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000389834-1120323_325354.0556.0Topological domainCytoplasmic
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000448392-101922_225293.0495.0Topological domainLumenal
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000448392-1019247_257293.0495.0Topological domainCytoplasmic
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000389834-1120226_246354.0556.0TransmembraneHelical%3B Name%3D1
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000389834-1120258_278354.0556.0TransmembraneHelical%3B Name%3D2
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000389834-1120306_322354.0556.0TransmembraneHelical%3B Name%3D3
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000389834-1120326_346354.0556.0TransmembraneHelical%3B Name%3D4
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000448392-1019226_246293.0495.0TransmembraneHelical%3B Name%3D1
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000448392-1019258_278293.0495.0TransmembraneHelical%3B Name%3D2
TgeneCAPN8chr15:42525411chr1:223718212ENST000003668721520588_599589.0682.0Calcium binding1
TgeneCAPN8chr15:42525411chr1:223718212ENST000003668721520618_629589.0682.0Calcium binding2
TgeneCAPN8chr15:42525411chr1:223718212ENST000003668721520605_640589.0682.0DomainEF-hand 2
TgeneCAPN8chr15:42525411chr1:223718212ENST000003668721520670_703589.0682.0DomainEF-hand 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000307216-17476_4820182.0Compositional biasNote=Poly-Glu
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000389834-1120476_482354.0556.0Compositional biasNote=Poly-Glu
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000448392-1019476_482293.0495.0Compositional biasNote=Poly-Glu
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000307216-1722_2250182.0Topological domainLumenal
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000307216-17247_2570182.0Topological domainCytoplasmic
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000307216-17279_3050182.0Topological domainLumenal
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000307216-17323_3250182.0Topological domainCytoplasmic
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000307216-17347_3610182.0Topological domainLumenal
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000307216-17383_4030182.0Topological domainCytoplasmic
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000307216-17425_4370182.0Topological domainLumenal
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000307216-17459_5550182.0Topological domainCytoplasmic
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000389834-1120347_361354.0556.0Topological domainLumenal
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000389834-1120383_403354.0556.0Topological domainCytoplasmic
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000389834-1120425_437354.0556.0Topological domainLumenal
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000389834-1120459_555354.0556.0Topological domainCytoplasmic
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000448392-1019279_305293.0495.0Topological domainLumenal
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000448392-1019323_325293.0495.0Topological domainCytoplasmic
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000448392-1019347_361293.0495.0Topological domainLumenal
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000448392-1019383_403293.0495.0Topological domainCytoplasmic
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000448392-1019425_437293.0495.0Topological domainLumenal
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000448392-1019459_555293.0495.0Topological domainCytoplasmic
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000307216-17226_2460182.0TransmembraneHelical%3B Name%3D1
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000307216-17258_2780182.0TransmembraneHelical%3B Name%3D2
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000307216-17306_3220182.0TransmembraneHelical%3B Name%3D3
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000307216-17326_3460182.0TransmembraneHelical%3B Name%3D4
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000307216-17362_3820182.0TransmembraneHelical%3B Name%3D5
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000307216-17404_4240182.0TransmembraneHelical%3B Name%3D6
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000307216-17438_4580182.0TransmembraneHelical%3B Name%3D7
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000389834-1120362_382354.0556.0TransmembraneHelical%3B Name%3D5
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000389834-1120404_424354.0556.0TransmembraneHelical%3B Name%3D6
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000389834-1120438_458354.0556.0TransmembraneHelical%3B Name%3D7
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000448392-1019306_322293.0495.0TransmembraneHelical%3B Name%3D3
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000448392-1019326_346293.0495.0TransmembraneHelical%3B Name%3D4
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000448392-1019362_382293.0495.0TransmembraneHelical%3B Name%3D5
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000448392-1019404_424293.0495.0TransmembraneHelical%3B Name%3D6
HgeneTMEM87Achr15:42525411chr1:223718212ENST00000448392-1019438_458293.0495.0TransmembraneHelical%3B Name%3D7
TgeneCAPN8chr15:42525411chr1:223718212ENST00000366872152045_344589.0682.0DomainCalpain catalytic
TgeneCAPN8chr15:42525411chr1:223718212ENST000003668721520575_610589.0682.0DomainEF-hand 1
TgeneCAPN8chr15:42525411chr1:223718212ENST000003668721520356_379589.0682.0RegionNote=Domain III


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Fusion Gene Sequence for TMEM87A-CAPN8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000389834_ENST00000366872_TCGA-BR-A4J9-01A_TMEM87A_chr15_42525411_-_CAPN8_chr1_223718212_length(transcript)=1822nt_BP=1327nt
AGAAAAGACTCAGGCCAGGCTGGCATGTAGCGATCTCTCTAACCCAGCTGACCAGGTTCCAACAGGATGACGCCTGCGCAGTAGGTCCAA
AGTCTCACGGCGCACAGACGACTGTCTGAGAGAGGGGCCGCTACGCCGCACAGCAAACAAGCTCCGCGACGTTTCCAGGACCCGGATAAT
CCCGCCCTTAGAGCAGAGCCGGAAGAAGGCGGGACGAACCGGAAGAGGGTGAAATGCTTTCGGTAGGCACTCCACGGCTGTGAAGATGGC
GGCGGCTGCGTGGCTTCAGGTGTTGCCTGTCATTCTTCTGCTTCTGGGAGCTCACCCGTCACCACTGTCGTTTTTCAGTGCGGGACCGGC
AACCGTAGCTGCTGCCGACCGGTCCAAATGGCACATTCCGATACCGTCGGGGAAAAATTATTTTAGTTTTGGAAAGATCCTCTTCAGAAA
TACCACTATCTTCCTGAAGTTTGATGGAGAACCTTGTGACCTGTCTTTGAATATAACCTGGTATCTGAAAAGCGCTGATTGTTACAATGA
AATCTATAACTTCAAGGCAGAAGAAGTAGAGTTGTATTTGGAAAAACTTAAGGAAAAAAGAGGCTTGTCTGGGAAATATCAAACATCATC
AAAATTGTTCCAGAACTGCAGTGAACTCTTTAAAACACAGACCTTTTCTGGAGATTTTATGCATCGACTGCCTCTTTTAGGAGAAAAACA
GGAGGCTAAGGAGAATGGAACAAACCTTACCTTTATTGGAGACAAAACCGCAATGCATGAACCATTGCAAACTTGGCAAGATGCACCATA
CATTTTTATTGTACATATTGGCATTTCATCCTCAAAGGAATCATCAAAAGAAAATTCACTGAGTAATCTTTTTACCATGACTGTTGAAGT
GAAGGGTCCCTATGAATACCTCACACTTGAAGACTATCCCTTGATGATTTTTTTCATGGTGATGTGTATTGTATATGTCCTGTTTGGTGT
TCTGTGGCTGGCATGGTCTGCCTGCTACTGGAGAGATCTCCTGAGAATTCAGTTTTGGATTGGTGCTGTCATCTTCCTGGGAATGCTTGA
GAAAGCTGTCTTCTATGCGGAATTTCAGAATATCCGATACAAAGGAGAATCTGTCCAGGGTGCTTTGATCCTTGCAGAGCTGCTTTCAGC
AGTGAAACGCTCACTGGCTCGAACCCTGGTCATCATAGTCAGTCTGGGATATGGCATCGTCAAGCCACGCCTTGGAGTCACTCTTCATAA
GGTTGTAGTAGCAGGAGCCCTCTATCTTTTGTTCTCTGGCATGGAAGGGGTCCTCAGAGTTACTGGGGAGATCTATTGGGAAACTGATTA
TAACCACTCGGGCACCATCGATGCCCACGAGATGAGGACAGCCCTCAGGAAGGCAGGTTTCACCCTCAACAGCCAGGTGCAGCAGACCAT
TGCCCTGCGGTATGCGTGCAGCAAGCTCGGCATCAACTTTGACAGCTTCGTGGCTTGTATGATCCGCCTGGAGACCCTCTTCAAACTATT
CAGCCTTCTGGACGAAGACAAGGATGGCATGGTTCAGCTCTCTCTGGCCGAGTGGCTGTGCTGCGTGTTGGTCTGACCCGGGGTTTCGGA
CATCAGTGACACTCCCTGCCCCACTGCTTGCTTCTTGTCACCCCTTCTCTACAATTTTGTGAACATTTATGCTCCAGTGGCATTCACTGG
TTGTTCATACCTTTCTTGCCCTGGGTCTATTTCAGCAGCACTGAGCTATGAGCTATGTAAGCCGACCCGGTGGGCCCAGTGGAGGGAAAG

>In-frame_ENST00000389834_ENST00000366872_TCGA-BR-A4J9-01A_TMEM87A_chr15_42525411_-_CAPN8_chr1_223718212_length(amino acids)=446AA_start in transcript=265_stop in transcript=1605
MAAAAWLQVLPVILLLLGAHPSPLSFFSAGPATVAAADRSKWHIPIPSGKNYFSFGKILFRNTTIFLKFDGEPCDLSLNITWYLKSADCY
NEIYNFKAEEVELYLEKLKEKRGLSGKYQTSSKLFQNCSELFKTQTFSGDFMHRLPLLGEKQEAKENGTNLTFIGDKTAMHEPLQTWQDA
PYIFIVHIGISSSKESSKENSLSNLFTMTVEVKGPYEYLTLEDYPLMIFFMVMCIVYVLFGVLWLAWSACYWRDLLRIQFWIGAVIFLGM
LEKAVFYAEFQNIRYKGESVQGALILAELLSAVKRSLARTLVIIVSLGYGIVKPRLGVTLHKVVVAGALYLLFSGMEGVLRVTGEIYWET

--------------------------------------------------------------
>In-frame_ENST00000448392_ENST00000366872_TCGA-BR-A4J9-01A_TMEM87A_chr15_42525411_-_CAPN8_chr1_223718212_length(transcript)=1538nt_BP=1043nt
AGAGGGTGAAATGCTTTCGGTAGGCACTCCACGGCTGTGAAGATGGCGGCGGCTGCGTGGCTTCAGGTGTTGCCTGTCATTCTTCTGCTT
CTGGGAGCTCACCCGTCACCACTGTCGTTTTTCAGTGCGGGACCGGCAACCGTAGCTGCTGCCGACCGGTCCAAATGGCACATTCCGATA
CCGTCGTTGATGGAGAACCTTGTGACCTGTCTTTGAATATAACCTGGTATCTGAAAAGCGCTGATTGTTACAATGAAATCTATAACTTCA
AGGCAGAAGAAGTAGAGTTGTATTTGGAAAAACTTAAGGAAAAAAGAGGCTTGTCTGGGAAATATCAAACATCATCAAAATTGTTCCAGA
ACTGCAGTGAACTCTTTAAAACACAGACCTTTTCTGGAGATTTTATGCATCGACTGCCTCTTTTAGGAGAAAAACAGGAGGCTAAGGAGA
ATGGAACAAACCTTACCTTTATTGGAGACAAAACCGCAATGCATGAACCATTGCAAACTTGGCAAGATGCACCATACATTTTTATTGTAC
ATATTGGCATTTCATCCTCAAAGGAATCATCAAAAGAAAATTCACTGAGTAATCTTTTTACCATGACTGTTGAAGTGAAGGGTCCCTATG
AATACCTCACACTTGAAGACTATCCCTTGATGATTTTTTTCATGGTGATGTGTATTGTATATGTCCTGTTTGGTGTTCTGTGGCTGGCAT
GGTCTGCCTGCTACTGGAGAGATCTCCTGAGAATTCAGTTTTGGATTGGTGCTGTCATCTTCCTGGGAATGCTTGAGAAAGCTGTCTTCT
ATGCGGAATTTCAGAATATCCGATACAAAGGAGAATCTGTCCAGGGTGCTTTGATCCTTGCAGAGCTGCTTTCAGCAGTGAAACGCTCAC
TGGCTCGAACCCTGGTCATCATAGTCAGTCTGGGATATGGCATCGTCAAGCCACGCCTTGGAGTCACTCTTCATAAGGTTGTAGTAGCAG
GAGCCCTCTATCTTTTGTTCTCTGGCATGGAAGGGGTCCTCAGAGTTACTGGGGAGATCTATTGGGAAACTGATTATAACCACTCGGGCA
CCATCGATGCCCACGAGATGAGGACAGCCCTCAGGAAGGCAGGTTTCACCCTCAACAGCCAGGTGCAGCAGACCATTGCCCTGCGGTATG
CGTGCAGCAAGCTCGGCATCAACTTTGACAGCTTCGTGGCTTGTATGATCCGCCTGGAGACCCTCTTCAAACTATTCAGCCTTCTGGACG
AAGACAAGGATGGCATGGTTCAGCTCTCTCTGGCCGAGTGGCTGTGCTGCGTGTTGGTCTGACCCGGGGTTTCGGACATCAGTGACACTC
CCTGCCCCACTGCTTGCTTCTTGTCACCCCTTCTCTACAATTTTGTGAACATTTATGCTCCAGTGGCATTCACTGGTTGTTCATACCTTT
CTTGCCCTGGGTCTATTTCAGCAGCACTGAGCTATGAGCTATGTAAGCCGACCCGGTGGGCCCAGTGGAGGGAAAGCAATCAATTAAAGT

>In-frame_ENST00000448392_ENST00000366872_TCGA-BR-A4J9-01A_TMEM87A_chr15_42525411_-_CAPN8_chr1_223718212_length(amino acids)=385AA_start in transcript=164_stop in transcript=1321
MAHSDTVVDGEPCDLSLNITWYLKSADCYNEIYNFKAEEVELYLEKLKEKRGLSGKYQTSSKLFQNCSELFKTQTFSGDFMHRLPLLGEK
QEAKENGTNLTFIGDKTAMHEPLQTWQDAPYIFIVHIGISSSKESSKENSLSNLFTMTVEVKGPYEYLTLEDYPLMIFFMVMCIVYVLFG
VLWLAWSACYWRDLLRIQFWIGAVIFLGMLEKAVFYAEFQNIRYKGESVQGALILAELLSAVKRSLARTLVIIVSLGYGIVKPRLGVTLH
KVVVAGALYLLFSGMEGVLRVTGEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TMEM87A-CAPN8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMEM87A-CAPN8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMEM87A-CAPN8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCAPN8C0007570Celiac Disease1CTD_human