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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMPRSS2-FKBP5 (FusionGDB2 ID:91742)

Fusion Gene Summary for TMPRSS2-FKBP5

check button Fusion gene summary
Fusion gene informationFusion gene name: TMPRSS2-FKBP5
Fusion gene ID: 91742
HgeneTgene
Gene symbol

TMPRSS2

FKBP5

Gene ID

7113

2289

Gene nametransmembrane serine protease 2FKBP prolyl isomerase 5
SynonymsPP9284|PRSS10AIG6|FKBP51|FKBP54|P54|PPIase|Ptg-10
Cytomap

21q22.3

6p21.31

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2peptidyl-prolyl cis-trans isomerase FKBP551 kDa FK506-binding protein51 kDa FKBP54 kDa progesterone receptor-associated immunophilinFF1 antigenFK506 binding protein 5FKBP-51HSP90-binding immunophilinPPIase FKBP5T-cell FK506-binding proteinandrog
Modification date2020031320200329
UniProtAcc.

Q13451

Ensembl transtripts involved in fusion geneENST00000332149, ENST00000398585, 
ENST00000458356, ENST00000497881, 
ENST00000539068, ENST00000536438, 
ENST00000357266, ENST00000540787, 
ENST00000542713, 
Fusion gene scores* DoF score40 X 73 X 10=2920013 X 10 X 9=1170
# samples 13015
** MAII scorelog2(130/29200*10)=-4.48938484073892
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1170*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMPRSS2 [Title/Abstract] AND FKBP5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMPRSS2(42880008)-FKBP5(35565184), # samples:2
TMPRSS2(42866283)-FKBP5(35565187), # samples:2
FKBP5(35586873)-TMPRSS2(42861520), # samples:1
Anticipated loss of major functional domain due to fusion event.TMPRSS2-FKBP5 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TMPRSS2-FKBP5 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMPRSS2

GO:0006508

proteolysis

21068237|24227843

HgeneTMPRSS2

GO:0046598

positive regulation of viral entry into host cell

21068237|24227843

TgeneFKBP5

GO:0061077

chaperone-mediated protein folding

11350175


check buttonFusion gene breakpoints across TMPRSS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FKBP5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AHM245387TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
ChiTaRS5.0N/AHM245388TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
ChiTaRS5.0N/AHM245389TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-
ChiTaRS5.0N/AHM245390TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-


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Fusion Gene ORF analysis for TMPRSS2-FKBP5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000332149ENST00000539068TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
5UTR-3CDSENST00000332149ENST00000536438TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
5UTR-3CDSENST00000332149ENST00000357266TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
5UTR-5UTRENST00000332149ENST00000540787TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
5UTR-5UTRENST00000332149ENST00000542713TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
intron-3CDSENST00000398585ENST00000539068TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
intron-3CDSENST00000398585ENST00000536438TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
intron-3CDSENST00000398585ENST00000357266TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
intron-5UTRENST00000398585ENST00000540787TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
intron-5UTRENST00000398585ENST00000542713TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
intron-3CDSENST00000458356ENST00000539068TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
intron-3CDSENST00000458356ENST00000536438TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
intron-3CDSENST00000458356ENST00000357266TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
intron-5UTRENST00000458356ENST00000540787TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
intron-5UTRENST00000458356ENST00000542713TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
5UTR-3CDSENST00000497881ENST00000539068TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
5UTR-3CDSENST00000497881ENST00000536438TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
5UTR-3CDSENST00000497881ENST00000357266TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
5UTR-5UTRENST00000497881ENST00000540787TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
5UTR-5UTRENST00000497881ENST00000542713TMPRSS2chr21

42880008

-FKBP5chr6

35565184

-
In-frameENST00000332149ENST00000539068TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-
In-frameENST00000332149ENST00000536438TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-
In-frameENST00000332149ENST00000357266TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-
5CDS-5UTRENST00000332149ENST00000540787TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-
5CDS-5UTRENST00000332149ENST00000542713TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-
In-frameENST00000398585ENST00000539068TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-
In-frameENST00000398585ENST00000536438TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-
In-frameENST00000398585ENST00000357266TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-
5CDS-5UTRENST00000398585ENST00000540787TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-
5CDS-5UTRENST00000398585ENST00000542713TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-
Frame-shiftENST00000458356ENST00000539068TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-
Frame-shiftENST00000458356ENST00000536438TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-
Frame-shiftENST00000458356ENST00000357266TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-
5CDS-5UTRENST00000458356ENST00000540787TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-
5CDS-5UTRENST00000458356ENST00000542713TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-
intron-3CDSENST00000497881ENST00000539068TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-
intron-3CDSENST00000497881ENST00000536438TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-
intron-3CDSENST00000497881ENST00000357266TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-
intron-5UTRENST00000497881ENST00000540787TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-
intron-5UTRENST00000497881ENST00000542713TMPRSS2chr21

42866283

-FKBP5chr6

35565187

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000332149TMPRSS2chr2142866283-ENST00000539068FKBP5chr635565187-34893731351238367
ENST00000332149TMPRSS2chr2142866283-ENST00000536438FKBP5chr635565187-34893731351238367
ENST00000332149TMPRSS2chr2142866283-ENST00000357266FKBP5chr635565187-34843731351238367
ENST00000398585TMPRSS2chr2142866283-ENST00000539068FKBP5chr635565187-3526410401275411
ENST00000398585TMPRSS2chr2142866283-ENST00000536438FKBP5chr635565187-3526410401275411
ENST00000398585TMPRSS2chr2142866283-ENST00000357266FKBP5chr635565187-3521410401275411

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000332149ENST00000539068TMPRSS2chr2142866283-FKBP5chr635565187-0.0002496020.99975044
ENST00000332149ENST00000536438TMPRSS2chr2142866283-FKBP5chr635565187-0.0002496020.99975044
ENST00000332149ENST00000357266TMPRSS2chr2142866283-FKBP5chr635565187-0.0002577750.9997422
ENST00000398585ENST00000539068TMPRSS2chr2142866283-FKBP5chr635565187-0.0004576770.99954236
ENST00000398585ENST00000536438TMPRSS2chr2142866283-FKBP5chr635565187-0.0004576770.99954236
ENST00000398585ENST00000357266TMPRSS2chr2142866283-FKBP5chr635565187-0.0004679070.9995321

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Fusion Genomic Features for TMPRSS2-FKBP5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMPRSS2-FKBP5


check button Go to

FGviewer for the breakpoints of chr21:42866283-chr6:35565187

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FKBP5

Q13451

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277). {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:12538866, ECO:0000269|PubMed:28147277}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42866283chr6:35565187ENST00000398585-3141_84116.33333333333333530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866283chr6:35565187ENST00000398585-31485_105116.33333333333333530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneFKBP5chr21:42866283chr6:35565187ENST00000357266411268_301169.33333333333334458.0RepeatNote=TPR 1
TgeneFKBP5chr21:42866283chr6:35565187ENST00000357266411317_350169.33333333333334458.0RepeatNote=TPR 2
TgeneFKBP5chr21:42866283chr6:35565187ENST00000357266411351_384169.33333333333334458.0RepeatNote=TPR 3
TgeneFKBP5chr21:42866283chr6:35565187ENST00000536438512268_301169.33333333333334458.0RepeatNote=TPR 1
TgeneFKBP5chr21:42866283chr6:35565187ENST00000536438512317_350169.33333333333334458.0RepeatNote=TPR 2
TgeneFKBP5chr21:42866283chr6:35565187ENST00000536438512351_384169.33333333333334458.0RepeatNote=TPR 3
TgeneFKBP5chr21:42866283chr6:35565187ENST00000539068411268_301169.33333333333334458.0RepeatNote=TPR 1
TgeneFKBP5chr21:42866283chr6:35565187ENST00000539068411317_350169.33333333333334458.0RepeatNote=TPR 2
TgeneFKBP5chr21:42866283chr6:35565187ENST00000539068411351_384169.33333333333334458.0RepeatNote=TPR 3
TgeneFKBP5chr21:42866283chr6:35565187ENST0000054271347268_301169.33333333333334269.0RepeatNote=TPR 1
TgeneFKBP5chr21:42866283chr6:35565187ENST0000054271347317_350169.33333333333334269.0RepeatNote=TPR 2
TgeneFKBP5chr21:42866283chr6:35565187ENST0000054271347351_384169.33333333333334269.0RepeatNote=TPR 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42866283chr6:35565187ENST00000332149-314112_14979.33333333333333493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866283chr6:35565187ENST00000332149-314150_24279.33333333333333493.0DomainSRCR
HgeneTMPRSS2chr21:42866283chr6:35565187ENST00000332149-314256_48979.33333333333333493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866283chr6:35565187ENST00000398585-314112_149116.33333333333333530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866283chr6:35565187ENST00000398585-314150_242116.33333333333333530.0DomainSRCR
HgeneTMPRSS2chr21:42866283chr6:35565187ENST00000398585-314256_489116.33333333333333530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866283chr6:35565187ENST00000458356-314112_14979.33333333333333493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866283chr6:35565187ENST00000458356-314150_24279.33333333333333493.0DomainSRCR
HgeneTMPRSS2chr21:42866283chr6:35565187ENST00000458356-314256_48979.33333333333333493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866283chr6:35565187ENST00000332149-314106_49279.33333333333333493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866283chr6:35565187ENST00000332149-3141_8479.33333333333333493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866283chr6:35565187ENST00000398585-314106_492116.33333333333333530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866283chr6:35565187ENST00000458356-314106_49279.33333333333333493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866283chr6:35565187ENST00000458356-3141_8479.33333333333333493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866283chr6:35565187ENST00000332149-31485_10579.33333333333333493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42866283chr6:35565187ENST00000458356-31485_10579.33333333333333493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneFKBP5chr21:42866283chr6:35565187ENST00000357266411157_243169.33333333333334458.0DomainPPIase FKBP-type 2
TgeneFKBP5chr21:42866283chr6:35565187ENST0000035726641142_130169.33333333333334458.0DomainPPIase FKBP-type 1
TgeneFKBP5chr21:42866283chr6:35565187ENST00000536438512157_243169.33333333333334458.0DomainPPIase FKBP-type 2
TgeneFKBP5chr21:42866283chr6:35565187ENST0000053643851242_130169.33333333333334458.0DomainPPIase FKBP-type 1
TgeneFKBP5chr21:42866283chr6:35565187ENST00000539068411157_243169.33333333333334458.0DomainPPIase FKBP-type 2
TgeneFKBP5chr21:42866283chr6:35565187ENST0000053906841142_130169.33333333333334458.0DomainPPIase FKBP-type 1
TgeneFKBP5chr21:42866283chr6:35565187ENST0000054271347157_243169.33333333333334269.0DomainPPIase FKBP-type 2
TgeneFKBP5chr21:42866283chr6:35565187ENST000005427134742_130169.33333333333334269.0DomainPPIase FKBP-type 1


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Fusion Gene Sequence for TMPRSS2-FKBP5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000332149_ENST00000539068_HM245389_TMPRSS2_chr21_42866283_-_FKBP5_chr6_35565187_length(transcript)=3489nt_BP=373nt
CGAGTAGGCGCGAGCTAAGCAGGAGGCGGAGGCGGAGGCGGAGGGCGAGGGGCGGGGAGCGCCGCCTGGAGCGCGGCAGGTCATATTGAA
CATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTAT
GAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTAC
CCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACA
GTGTGCACCTCAATCCACCTGGAAGGCCGCTGTGGTGGAAGGATGTTTGACTGCAGAGATGTGGCATTCACTGTGGGCGAAGGAGAAGAC
CACGACATTCCAATTGGAATTGACAAAGCTCTGGAGAAAATGCAGCGGGAAGAACAATGTATTTTATATCTTGGACCAAGATATGGTTTT
GGAGAGGCAGGGAAGCCTAAATTTGGCATTGAACCTAATGCTGAGCTTATATATGAAGTTACACTTAAGAGCTTCGAAAAGGCCAAAGAA
TCCTGGGAGATGGATACCAAAGAAAAATTGGAGCAGGCTGCCATTGTCAAAGAGAAGGGAACCGTATACTTCAAGGGAGGCAAATACATG
CAGGCGGTGATTCAGTATGGGAAGATAGTGTCCTGGTTAGAGATGGAATATGGTTTATCAGAAAAGGAATCGAAAGCTTCTGAATCATTT
CTCCTTGCTGCCTTTCTGAACCTGGCCATGTGCTACCTGAAGCTTAGAGAATACACCAAAGCTGTTGAATGCTGTGACAAGGCCCTTGGA
CTGGACAGTGCCAATGAGAAAGGCTTGTATAGGAGGGGTGAAGCCCAGCTGCTCATGAACGAGTTTGAGTCAGCCAAGGGTGACTTTGAG
AAAGTGCTGGAAGTAAACCCCCAGAATAAGGCTGCAAGACTGCAGATCTCCATGTGCCAGAAAAAGGCCAAGGAGCACAACGAGCGGGAC
CGCAGGATATACGCCAACATGTTCAAGAAGTTTGCAGAGCAGGATGCCAAGGAAGAGGCCAATAAAGCAATGGGCAAGAAGACTTCAGAA
GGGGTCACTAATGAAAAAGGAACAGACAGTCAAGCAATGGAAGAAGAGAAACCTGAGGGCCACGTATGACGCCACGCCAAGGAGGGAAGA
GTCCCAGTGAACTCGGCCCCTCCTCAATGGGCTTTCCCCCAACTCAGGACAGAACAGTGTTTAATGTAAAGTTTGTTATAGTCTATGTGA
TTCTGGAAGCAAATGGCAAAACCAGTAGCTTCCCAAAAACAGCCCCCCTGCTGCTGCCCGGAGGGTTCACTGAGGGGTGGCACGGGACCA
CTCCAGGTGGAACAAACAGAAATGACTGTGGTGTGGAGGGAGTGAGCCAGCAGCTTAAGTCCAGCTCATTTCAGTTTCTATCAACCTTCA
AGTATCCAATTCAGGGTCCCTGGAGATCATCCTAACAATGTGGGGCTGTTAGGTTTTACCTTTGAACTTTCATAGCACTGCAGAAACCTT
TAAAAAAAAAATGCTTCATGAATTTCTCCTTTCCTACAGTTGGGTAGGGTAGGGGAAGGAGGATAAGCTTTTGTTTTTTAAATGACTGAA
GTGCTATAAATGTAGTCTGTTGCATTTTTAACCAACAGAACCCACAGTAGAGGGGTCTCATGTCTCCCCAGTTCCACAGCAGTGTCACAG
ACGTGAAAGCCAGAACCTCAGAGGCCACTTGCTTGCTGACTTAGCCTCCTCCCAAAGTCCCCCTCCTCAGCCAGCCTCCTTGTGAGAGTG
GCTTTCTACCACACACAGCCTGTCCCTGGGGGAGTAATTCTGTCATTCCTAAAACACCCTTCAGCAATGATAATGAGCAGATGAGAGTTT
CTGGATTAGCTTTTCCTATTTTCGATGAAGTTCTGAGATACTGAAATGTGAAAAGAGCAATCAGAATTGTGCTTTTTCTCCCCTCCTCTA
TTCCTTTTAGGGAATAATATTCAATACACAGTACTTCCTCCCAGCATTGCTACTGCTCAGCTTCTTCTTTCATTCTAATCCTTGCTATTA
AGAATTTAAGACTTGTGCTTACAATATTTTTGACCTGGAGTGGATCTATTTACATAGTCATTTAGGATCCATGCAGCTTTTTTTGTCTTT
TTAAGATTATTGGCTCATAAGCATATGTATACTGGTTTATGGAACTTTATTTACACTCCTCTATCATGCAAAAAAATTTTGACTTTTTAG
TACTAAGCTTAATTTTTAAAAACAAAATCTGTAGGGTTGACAAATAAATAGTTGCTCTTCTACACTAGGGGTTTCACCTGCAGGTTTGAC
ACGCAGTTGCTCGCTTTTCCTGCCCTGTCAAGCTTCTCTGTTCTGGCGTGAGTTGTGAAAGAGTTGAAGACAGCTTCCCATGCCGGTACA
CAGCCAGTAGCCTAAATCTCCAGTACTTGAGCTGACCATTGAACTAGGGCAAGTCTTAAATGTGTACATGTAGTTGAATTTCAGTCCTTA
CGGGTAAACAGATTGAGCATGGCTCTCTATTCCCTCAGCCTAAGAAACACTCATGGGAATGCATTTGGCAACCCAAGGAACCATTTGCTT
AAACCTGGAACATCTCACCTTTTTAAATCCTAAAAAACACTGGCAGTTATATTTTAAATTAGTTTTTATTTTTATGATGGTTTTATCAAA
AGACTTTTATTATTAGATTGGGACCCCCTTCAAACCTAAAAATCAAGTTATTTCCTTTTATAATACTTTTCTTCCCCATGGAACAAATGG
GATCAATTTGTGAGTTTTTTCCTTTAATGATAACTAAAATCCCTCTAATTTCTCATTTATGCTTTTGTCTTTTTTATGAAATATTTCTTT
TAAAAGCCCCAGTCTCACCTACGAAATATGAAGAGCAAAAGCTGATTTTGCTTACTTGCTAAACTGTTGGGAAAGCTCTGTAGAGCATGG
TTCCAGTGAGGCCAAGATTGAAATTTGATACTAAAAAGGCCACCTAGCTTTTTGCAGATAACAAACAAGAAAGCTATTCCAAGACTCAGA
TGATGCCAGCTGTCTCCCACGTGTGTATTATGGTTCACCAGGGGGAACTGGCAAAAGTGTGTGTGGGGAGGGGAAGGGTGTGTGAGTGGT
TCTGAGCAAATAACTACAGGGTGCCCATTACCACTCAAGAAGACACTTCACGTATTCTTGTATCAAATTCAATAATCTTAAACAATTTGT
GTAGAAGTCCACAGACATCTTTCAACCACCTTTTAGGCTGCATATGGATTGCCAAGTCAGCATATGAGGAATTAAAGACATTGTTTTTAA

>In-frame_ENST00000332149_ENST00000539068_HM245389_TMPRSS2_chr21_42866283_-_FKBP5_chr6_35565187_length(amino acids)=367AA_start in transcript=135_stop in transcript=1238
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSIHLEGRCGGRM
FDCRDVAFTVGEGEDHDIPIGIDKALEKMQREEQCILYLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAI
VKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEA
QLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEANKAMGKKTSEGVTNEKGTDSQAMEE

--------------------------------------------------------------
>In-frame_ENST00000332149_ENST00000536438_HM245389_TMPRSS2_chr21_42866283_-_FKBP5_chr6_35565187_length(transcript)=3489nt_BP=373nt
CGAGTAGGCGCGAGCTAAGCAGGAGGCGGAGGCGGAGGCGGAGGGCGAGGGGCGGGGAGCGCCGCCTGGAGCGCGGCAGGTCATATTGAA
CATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTAT
GAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTAC
CCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACA
GTGTGCACCTCAATCCACCTGGAAGGCCGCTGTGGTGGAAGGATGTTTGACTGCAGAGATGTGGCATTCACTGTGGGCGAAGGAGAAGAC
CACGACATTCCAATTGGAATTGACAAAGCTCTGGAGAAAATGCAGCGGGAAGAACAATGTATTTTATATCTTGGACCAAGATATGGTTTT
GGAGAGGCAGGGAAGCCTAAATTTGGCATTGAACCTAATGCTGAGCTTATATATGAAGTTACACTTAAGAGCTTCGAAAAGGCCAAAGAA
TCCTGGGAGATGGATACCAAAGAAAAATTGGAGCAGGCTGCCATTGTCAAAGAGAAGGGAACCGTATACTTCAAGGGAGGCAAATACATG
CAGGCGGTGATTCAGTATGGGAAGATAGTGTCCTGGTTAGAGATGGAATATGGTTTATCAGAAAAGGAATCGAAAGCTTCTGAATCATTT
CTCCTTGCTGCCTTTCTGAACCTGGCCATGTGCTACCTGAAGCTTAGAGAATACACCAAAGCTGTTGAATGCTGTGACAAGGCCCTTGGA
CTGGACAGTGCCAATGAGAAAGGCTTGTATAGGAGGGGTGAAGCCCAGCTGCTCATGAACGAGTTTGAGTCAGCCAAGGGTGACTTTGAG
AAAGTGCTGGAAGTAAACCCCCAGAATAAGGCTGCAAGACTGCAGATCTCCATGTGCCAGAAAAAGGCCAAGGAGCACAACGAGCGGGAC
CGCAGGATATACGCCAACATGTTCAAGAAGTTTGCAGAGCAGGATGCCAAGGAAGAGGCCAATAAAGCAATGGGCAAGAAGACTTCAGAA
GGGGTCACTAATGAAAAAGGAACAGACAGTCAAGCAATGGAAGAAGAGAAACCTGAGGGCCACGTATGACGCCACGCCAAGGAGGGAAGA
GTCCCAGTGAACTCGGCCCCTCCTCAATGGGCTTTCCCCCAACTCAGGACAGAACAGTGTTTAATGTAAAGTTTGTTATAGTCTATGTGA
TTCTGGAAGCAAATGGCAAAACCAGTAGCTTCCCAAAAACAGCCCCCCTGCTGCTGCCCGGAGGGTTCACTGAGGGGTGGCACGGGACCA
CTCCAGGTGGAACAAACAGAAATGACTGTGGTGTGGAGGGAGTGAGCCAGCAGCTTAAGTCCAGCTCATTTCAGTTTCTATCAACCTTCA
AGTATCCAATTCAGGGTCCCTGGAGATCATCCTAACAATGTGGGGCTGTTAGGTTTTACCTTTGAACTTTCATAGCACTGCAGAAACCTT
TAAAAAAAAAATGCTTCATGAATTTCTCCTTTCCTACAGTTGGGTAGGGTAGGGGAAGGAGGATAAGCTTTTGTTTTTTAAATGACTGAA
GTGCTATAAATGTAGTCTGTTGCATTTTTAACCAACAGAACCCACAGTAGAGGGGTCTCATGTCTCCCCAGTTCCACAGCAGTGTCACAG
ACGTGAAAGCCAGAACCTCAGAGGCCACTTGCTTGCTGACTTAGCCTCCTCCCAAAGTCCCCCTCCTCAGCCAGCCTCCTTGTGAGAGTG
GCTTTCTACCACACACAGCCTGTCCCTGGGGGAGTAATTCTGTCATTCCTAAAACACCCTTCAGCAATGATAATGAGCAGATGAGAGTTT
CTGGATTAGCTTTTCCTATTTTCGATGAAGTTCTGAGATACTGAAATGTGAAAAGAGCAATCAGAATTGTGCTTTTTCTCCCCTCCTCTA
TTCCTTTTAGGGAATAATATTCAATACACAGTACTTCCTCCCAGCATTGCTACTGCTCAGCTTCTTCTTTCATTCTAATCCTTGCTATTA
AGAATTTAAGACTTGTGCTTACAATATTTTTGACCTGGAGTGGATCTATTTACATAGTCATTTAGGATCCATGCAGCTTTTTTTGTCTTT
TTAAGATTATTGGCTCATAAGCATATGTATACTGGTTTATGGAACTTTATTTACACTCCTCTATCATGCAAAAAAATTTTGACTTTTTAG
TACTAAGCTTAATTTTTAAAAACAAAATCTGTAGGGTTGACAAATAAATAGTTGCTCTTCTACACTAGGGGTTTCACCTGCAGGTTTGAC
ACGCAGTTGCTCGCTTTTCCTGCCCTGTCAAGCTTCTCTGTTCTGGCGTGAGTTGTGAAAGAGTTGAAGACAGCTTCCCATGCCGGTACA
CAGCCAGTAGCCTAAATCTCCAGTACTTGAGCTGACCATTGAACTAGGGCAAGTCTTAAATGTGTACATGTAGTTGAATTTCAGTCCTTA
CGGGTAAACAGATTGAGCATGGCTCTCTATTCCCTCAGCCTAAGAAACACTCATGGGAATGCATTTGGCAACCCAAGGAACCATTTGCTT
AAACCTGGAACATCTCACCTTTTTAAATCCTAAAAAACACTGGCAGTTATATTTTAAATTAGTTTTTATTTTTATGATGGTTTTATCAAA
AGACTTTTATTATTAGATTGGGACCCCCTTCAAACCTAAAAATCAAGTTATTTCCTTTTATAATACTTTTCTTCCCCATGGAACAAATGG
GATCAATTTGTGAGTTTTTTCCTTTAATGATAACTAAAATCCCTCTAATTTCTCATTTATGCTTTTGTCTTTTTTATGAAATATTTCTTT
TAAAAGCCCCAGTCTCACCTACGAAATATGAAGAGCAAAAGCTGATTTTGCTTACTTGCTAAACTGTTGGGAAAGCTCTGTAGAGCATGG
TTCCAGTGAGGCCAAGATTGAAATTTGATACTAAAAAGGCCACCTAGCTTTTTGCAGATAACAAACAAGAAAGCTATTCCAAGACTCAGA
TGATGCCAGCTGTCTCCCACGTGTGTATTATGGTTCACCAGGGGGAACTGGCAAAAGTGTGTGTGGGGAGGGGAAGGGTGTGTGAGTGGT
TCTGAGCAAATAACTACAGGGTGCCCATTACCACTCAAGAAGACACTTCACGTATTCTTGTATCAAATTCAATAATCTTAAACAATTTGT
GTAGAAGTCCACAGACATCTTTCAACCACCTTTTAGGCTGCATATGGATTGCCAAGTCAGCATATGAGGAATTAAAGACATTGTTTTTAA

>In-frame_ENST00000332149_ENST00000536438_HM245389_TMPRSS2_chr21_42866283_-_FKBP5_chr6_35565187_length(amino acids)=367AA_start in transcript=135_stop in transcript=1238
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSIHLEGRCGGRM
FDCRDVAFTVGEGEDHDIPIGIDKALEKMQREEQCILYLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAI
VKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEA
QLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEANKAMGKKTSEGVTNEKGTDSQAMEE

--------------------------------------------------------------
>In-frame_ENST00000332149_ENST00000357266_HM245389_TMPRSS2_chr21_42866283_-_FKBP5_chr6_35565187_length(transcript)=3484nt_BP=373nt
CGAGTAGGCGCGAGCTAAGCAGGAGGCGGAGGCGGAGGCGGAGGGCGAGGGGCGGGGAGCGCCGCCTGGAGCGCGGCAGGTCATATTGAA
CATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTAT
GAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTAC
CCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACA
GTGTGCACCTCAATCCACCTGGAAGGCCGCTGTGGTGGAAGGATGTTTGACTGCAGAGATGTGGCATTCACTGTGGGCGAAGGAGAAGAC
CACGACATTCCAATTGGAATTGACAAAGCTCTGGAGAAAATGCAGCGGGAAGAACAATGTATTTTATATCTTGGACCAAGATATGGTTTT
GGAGAGGCAGGGAAGCCTAAATTTGGCATTGAACCTAATGCTGAGCTTATATATGAAGTTACACTTAAGAGCTTCGAAAAGGCCAAAGAA
TCCTGGGAGATGGATACCAAAGAAAAATTGGAGCAGGCTGCCATTGTCAAAGAGAAGGGAACCGTATACTTCAAGGGAGGCAAATACATG
CAGGCGGTGATTCAGTATGGGAAGATAGTGTCCTGGTTAGAGATGGAATATGGTTTATCAGAAAAGGAATCGAAAGCTTCTGAATCATTT
CTCCTTGCTGCCTTTCTGAACCTGGCCATGTGCTACCTGAAGCTTAGAGAATACACCAAAGCTGTTGAATGCTGTGACAAGGCCCTTGGA
CTGGACAGTGCCAATGAGAAAGGCTTGTATAGGAGGGGTGAAGCCCAGCTGCTCATGAACGAGTTTGAGTCAGCCAAGGGTGACTTTGAG
AAAGTGCTGGAAGTAAACCCCCAGAATAAGGCTGCAAGACTGCAGATCTCCATGTGCCAGAAAAAGGCCAAGGAGCACAACGAGCGGGAC
CGCAGGATATACGCCAACATGTTCAAGAAGTTTGCAGAGCAGGATGCCAAGGAAGAGGCCAATAAAGCAATGGGCAAGAAGACTTCAGAA
GGGGTCACTAATGAAAAAGGAACAGACAGTCAAGCAATGGAAGAAGAGAAACCTGAGGGCCACGTATGACGCCACGCCAAGGAGGGAAGA
GTCCCAGTGAACTCGGCCCCTCCTCAATGGGCTTTCCCCCAACTCAGGACAGAACAGTGTTTAATGTAAAGTTTGTTATAGTCTATGTGA
TTCTGGAAGCAAATGGCAAAACCAGTAGCTTCCCAAAAACAGCCCCCCTGCTGCTGCCCGGAGGGTTCACTGAGGGGTGGCACGGGACCA
CTCCAGGTGGAACAAACAGAAATGACTGTGGTGTGGAGGGAGTGAGCCAGCAGCTTAAGTCCAGCTCATTTCAGTTTCTATCAACCTTCA
AGTATCCAATTCAGGGTCCCTGGAGATCATCCTAACAATGTGGGGCTGTTAGGTTTTACCTTTGAACTTTCATAGCACTGCAGAAACCTT
TAAAAAAAAAATGCTTCATGAATTTCTCCTTTCCTACAGTTGGGTAGGGTAGGGGAAGGAGGATAAGCTTTTGTTTTTTAAATGACTGAA
GTGCTATAAATGTAGTCTGTTGCATTTTTAACCAACAGAACCCACAGTAGAGGGGTCTCATGTCTCCCCAGTTCCACAGCAGTGTCACAG
ACGTGAAAGCCAGAACCTCAGAGGCCACTTGCTTGCTGACTTAGCCTCCTCCCAAAGTCCCCCTCCTCAGCCAGCCTCCTTGTGAGAGTG
GCTTTCTACCACACACAGCCTGTCCCTGGGGGAGTAATTCTGTCATTCCTAAAACACCCTTCAGCAATGATAATGAGCAGATGAGAGTTT
CTGGATTAGCTTTTCCTATTTTCGATGAAGTTCTGAGATACTGAAATGTGAAAAGAGCAATCAGAATTGTGCTTTTTCTCCCCTCCTCTA
TTCCTTTTAGGGAATAATATTCAATACACAGTACTTCCTCCCAGCATTGCTACTGCTCAGCTTCTTCTTTCATTCTAATCCTTGCTATTA
AGAATTTAAGACTTGTGCTTACAATATTTTTGACCTGGAGTGGATCTATTTACATAGTCATTTAGGATCCATGCAGCTTTTTTTGTCTTT
TTAAGATTATTGGCTCATAAGCATATGTATACTGGTTTATGGAACTTTATTTACACTCCTCTATCATGCAAAAAAATTTTGACTTTTTAG
TACTAAGCTTAATTTTTAAAAACAAAATCTGTAGGGTTGACAAATAAATAGTTGCTCTTCTACACTAGGGGTTTCACCTGCAGGTTTGAC
ACGCAGTTGCTCGCTTTTCCTGCCCTGTCAAGCTTCTCTGTTCTGGCGTGAGTTGTGAAAGAGTTGAAGACAGCTTCCCATGCCGGTACA
CAGCCAGTAGCCTAAATCTCCAGTACTTGAGCTGACCATTGAACTAGGGCAAGTCTTAAATGTGTACATGTAGTTGAATTTCAGTCCTTA
CGGGTAAACAGATTGAGCATGGCTCTCTATTCCCTCAGCCTAAGAAACACTCATGGGAATGCATTTGGCAACCCAAGGAACCATTTGCTT
AAACCTGGAACATCTCACCTTTTTAAATCCTAAAAAACACTGGCAGTTATATTTTAAATTAGTTTTTATTTTTATGATGGTTTTATCAAA
AGACTTTTATTATTAGATTGGGACCCCCTTCAAACCTAAAAATCAAGTTATTTCCTTTTATAATACTTTTCTTCCCCATGGAACAAATGG
GATCAATTTGTGAGTTTTTTCCTTTAATGATAACTAAAATCCCTCTAATTTCTCATTTATGCTTTTGTCTTTTTTATGAAATATTTCTTT
TAAAAGCCCCAGTCTCACCTACGAAATATGAAGAGCAAAAGCTGATTTTGCTTACTTGCTAAACTGTTGGGAAAGCTCTGTAGAGCATGG
TTCCAGTGAGGCCAAGATTGAAATTTGATACTAAAAAGGCCACCTAGCTTTTTGCAGATAACAAACAAGAAAGCTATTCCAAGACTCAGA
TGATGCCAGCTGTCTCCCACGTGTGTATTATGGTTCACCAGGGGGAACTGGCAAAAGTGTGTGTGGGGAGGGGAAGGGTGTGTGAGTGGT
TCTGAGCAAATAACTACAGGGTGCCCATTACCACTCAAGAAGACACTTCACGTATTCTTGTATCAAATTCAATAATCTTAAACAATTTGT
GTAGAAGTCCACAGACATCTTTCAACCACCTTTTAGGCTGCATATGGATTGCCAAGTCAGCATATGAGGAATTAAAGACATTGTTTTTAA

>In-frame_ENST00000332149_ENST00000357266_HM245389_TMPRSS2_chr21_42866283_-_FKBP5_chr6_35565187_length(amino acids)=367AA_start in transcript=135_stop in transcript=1238
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSIHLEGRCGGRM
FDCRDVAFTVGEGEDHDIPIGIDKALEKMQREEQCILYLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAI
VKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEA
QLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEANKAMGKKTSEGVTNEKGTDSQAMEE

--------------------------------------------------------------
>In-frame_ENST00000398585_ENST00000539068_HM245389_TMPRSS2_chr21_42866283_-_FKBP5_chr6_35565187_length(transcript)=3526nt_BP=410nt
ACCAGGGTCCCGGCTCGGGGTCCGGGCTGGGGAGGGGAACCTGGGCGCCTGGGACCCGCCGATGCCCCCTGCCCCGCCCGGAGGTGAAAG
CGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTT
GAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGT
CCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCC
CGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAATCCACCTGGAAGGCCGCTGTGGTGGAAGGATGTTTGACTG
CAGAGATGTGGCATTCACTGTGGGCGAAGGAGAAGACCACGACATTCCAATTGGAATTGACAAAGCTCTGGAGAAAATGCAGCGGGAAGA
ACAATGTATTTTATATCTTGGACCAAGATATGGTTTTGGAGAGGCAGGGAAGCCTAAATTTGGCATTGAACCTAATGCTGAGCTTATATA
TGAAGTTACACTTAAGAGCTTCGAAAAGGCCAAAGAATCCTGGGAGATGGATACCAAAGAAAAATTGGAGCAGGCTGCCATTGTCAAAGA
GAAGGGAACCGTATACTTCAAGGGAGGCAAATACATGCAGGCGGTGATTCAGTATGGGAAGATAGTGTCCTGGTTAGAGATGGAATATGG
TTTATCAGAAAAGGAATCGAAAGCTTCTGAATCATTTCTCCTTGCTGCCTTTCTGAACCTGGCCATGTGCTACCTGAAGCTTAGAGAATA
CACCAAAGCTGTTGAATGCTGTGACAAGGCCCTTGGACTGGACAGTGCCAATGAGAAAGGCTTGTATAGGAGGGGTGAAGCCCAGCTGCT
CATGAACGAGTTTGAGTCAGCCAAGGGTGACTTTGAGAAAGTGCTGGAAGTAAACCCCCAGAATAAGGCTGCAAGACTGCAGATCTCCAT
GTGCCAGAAAAAGGCCAAGGAGCACAACGAGCGGGACCGCAGGATATACGCCAACATGTTCAAGAAGTTTGCAGAGCAGGATGCCAAGGA
AGAGGCCAATAAAGCAATGGGCAAGAAGACTTCAGAAGGGGTCACTAATGAAAAAGGAACAGACAGTCAAGCAATGGAAGAAGAGAAACC
TGAGGGCCACGTATGACGCCACGCCAAGGAGGGAAGAGTCCCAGTGAACTCGGCCCCTCCTCAATGGGCTTTCCCCCAACTCAGGACAGA
ACAGTGTTTAATGTAAAGTTTGTTATAGTCTATGTGATTCTGGAAGCAAATGGCAAAACCAGTAGCTTCCCAAAAACAGCCCCCCTGCTG
CTGCCCGGAGGGTTCACTGAGGGGTGGCACGGGACCACTCCAGGTGGAACAAACAGAAATGACTGTGGTGTGGAGGGAGTGAGCCAGCAG
CTTAAGTCCAGCTCATTTCAGTTTCTATCAACCTTCAAGTATCCAATTCAGGGTCCCTGGAGATCATCCTAACAATGTGGGGCTGTTAGG
TTTTACCTTTGAACTTTCATAGCACTGCAGAAACCTTTAAAAAAAAAATGCTTCATGAATTTCTCCTTTCCTACAGTTGGGTAGGGTAGG
GGAAGGAGGATAAGCTTTTGTTTTTTAAATGACTGAAGTGCTATAAATGTAGTCTGTTGCATTTTTAACCAACAGAACCCACAGTAGAGG
GGTCTCATGTCTCCCCAGTTCCACAGCAGTGTCACAGACGTGAAAGCCAGAACCTCAGAGGCCACTTGCTTGCTGACTTAGCCTCCTCCC
AAAGTCCCCCTCCTCAGCCAGCCTCCTTGTGAGAGTGGCTTTCTACCACACACAGCCTGTCCCTGGGGGAGTAATTCTGTCATTCCTAAA
ACACCCTTCAGCAATGATAATGAGCAGATGAGAGTTTCTGGATTAGCTTTTCCTATTTTCGATGAAGTTCTGAGATACTGAAATGTGAAA
AGAGCAATCAGAATTGTGCTTTTTCTCCCCTCCTCTATTCCTTTTAGGGAATAATATTCAATACACAGTACTTCCTCCCAGCATTGCTAC
TGCTCAGCTTCTTCTTTCATTCTAATCCTTGCTATTAAGAATTTAAGACTTGTGCTTACAATATTTTTGACCTGGAGTGGATCTATTTAC
ATAGTCATTTAGGATCCATGCAGCTTTTTTTGTCTTTTTAAGATTATTGGCTCATAAGCATATGTATACTGGTTTATGGAACTTTATTTA
CACTCCTCTATCATGCAAAAAAATTTTGACTTTTTAGTACTAAGCTTAATTTTTAAAAACAAAATCTGTAGGGTTGACAAATAAATAGTT
GCTCTTCTACACTAGGGGTTTCACCTGCAGGTTTGACACGCAGTTGCTCGCTTTTCCTGCCCTGTCAAGCTTCTCTGTTCTGGCGTGAGT
TGTGAAAGAGTTGAAGACAGCTTCCCATGCCGGTACACAGCCAGTAGCCTAAATCTCCAGTACTTGAGCTGACCATTGAACTAGGGCAAG
TCTTAAATGTGTACATGTAGTTGAATTTCAGTCCTTACGGGTAAACAGATTGAGCATGGCTCTCTATTCCCTCAGCCTAAGAAACACTCA
TGGGAATGCATTTGGCAACCCAAGGAACCATTTGCTTAAACCTGGAACATCTCACCTTTTTAAATCCTAAAAAACACTGGCAGTTATATT
TTAAATTAGTTTTTATTTTTATGATGGTTTTATCAAAAGACTTTTATTATTAGATTGGGACCCCCTTCAAACCTAAAAATCAAGTTATTT
CCTTTTATAATACTTTTCTTCCCCATGGAACAAATGGGATCAATTTGTGAGTTTTTTCCTTTAATGATAACTAAAATCCCTCTAATTTCT
CATTTATGCTTTTGTCTTTTTTATGAAATATTTCTTTTAAAAGCCCCAGTCTCACCTACGAAATATGAAGAGCAAAAGCTGATTTTGCTT
ACTTGCTAAACTGTTGGGAAAGCTCTGTAGAGCATGGTTCCAGTGAGGCCAAGATTGAAATTTGATACTAAAAAGGCCACCTAGCTTTTT
GCAGATAACAAACAAGAAAGCTATTCCAAGACTCAGATGATGCCAGCTGTCTCCCACGTGTGTATTATGGTTCACCAGGGGGAACTGGCA
AAAGTGTGTGTGGGGAGGGGAAGGGTGTGTGAGTGGTTCTGAGCAAATAACTACAGGGTGCCCATTACCACTCAAGAAGACACTTCACGT
ATTCTTGTATCAAATTCAATAATCTTAAACAATTTGTGTAGAAGTCCACAGACATCTTTCAACCACCTTTTAGGCTGCATATGGATTGCC
AAGTCAGCATATGAGGAATTAAAGACATTGTTTTTAAAAAAAAAAAATCATTTAGATGCACTTTTTTGTGTGTTCTTTAAATAAATCCAA

>In-frame_ENST00000398585_ENST00000539068_HM245389_TMPRSS2_chr21_42866283_-_FKBP5_chr6_35565187_length(amino acids)=411AA_start in transcript=40_stop in transcript=1275
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSIHLEGRCGGRMFDCRDVAFTVGEGEDHDIPIGIDKALEKMQREEQCILYLGPRYGFG
EAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFL
LAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDR

--------------------------------------------------------------
>In-frame_ENST00000398585_ENST00000536438_HM245389_TMPRSS2_chr21_42866283_-_FKBP5_chr6_35565187_length(transcript)=3526nt_BP=410nt
ACCAGGGTCCCGGCTCGGGGTCCGGGCTGGGGAGGGGAACCTGGGCGCCTGGGACCCGCCGATGCCCCCTGCCCCGCCCGGAGGTGAAAG
CGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTT
GAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGT
CCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCC
CGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAATCCACCTGGAAGGCCGCTGTGGTGGAAGGATGTTTGACTG
CAGAGATGTGGCATTCACTGTGGGCGAAGGAGAAGACCACGACATTCCAATTGGAATTGACAAAGCTCTGGAGAAAATGCAGCGGGAAGA
ACAATGTATTTTATATCTTGGACCAAGATATGGTTTTGGAGAGGCAGGGAAGCCTAAATTTGGCATTGAACCTAATGCTGAGCTTATATA
TGAAGTTACACTTAAGAGCTTCGAAAAGGCCAAAGAATCCTGGGAGATGGATACCAAAGAAAAATTGGAGCAGGCTGCCATTGTCAAAGA
GAAGGGAACCGTATACTTCAAGGGAGGCAAATACATGCAGGCGGTGATTCAGTATGGGAAGATAGTGTCCTGGTTAGAGATGGAATATGG
TTTATCAGAAAAGGAATCGAAAGCTTCTGAATCATTTCTCCTTGCTGCCTTTCTGAACCTGGCCATGTGCTACCTGAAGCTTAGAGAATA
CACCAAAGCTGTTGAATGCTGTGACAAGGCCCTTGGACTGGACAGTGCCAATGAGAAAGGCTTGTATAGGAGGGGTGAAGCCCAGCTGCT
CATGAACGAGTTTGAGTCAGCCAAGGGTGACTTTGAGAAAGTGCTGGAAGTAAACCCCCAGAATAAGGCTGCAAGACTGCAGATCTCCAT
GTGCCAGAAAAAGGCCAAGGAGCACAACGAGCGGGACCGCAGGATATACGCCAACATGTTCAAGAAGTTTGCAGAGCAGGATGCCAAGGA
AGAGGCCAATAAAGCAATGGGCAAGAAGACTTCAGAAGGGGTCACTAATGAAAAAGGAACAGACAGTCAAGCAATGGAAGAAGAGAAACC
TGAGGGCCACGTATGACGCCACGCCAAGGAGGGAAGAGTCCCAGTGAACTCGGCCCCTCCTCAATGGGCTTTCCCCCAACTCAGGACAGA
ACAGTGTTTAATGTAAAGTTTGTTATAGTCTATGTGATTCTGGAAGCAAATGGCAAAACCAGTAGCTTCCCAAAAACAGCCCCCCTGCTG
CTGCCCGGAGGGTTCACTGAGGGGTGGCACGGGACCACTCCAGGTGGAACAAACAGAAATGACTGTGGTGTGGAGGGAGTGAGCCAGCAG
CTTAAGTCCAGCTCATTTCAGTTTCTATCAACCTTCAAGTATCCAATTCAGGGTCCCTGGAGATCATCCTAACAATGTGGGGCTGTTAGG
TTTTACCTTTGAACTTTCATAGCACTGCAGAAACCTTTAAAAAAAAAATGCTTCATGAATTTCTCCTTTCCTACAGTTGGGTAGGGTAGG
GGAAGGAGGATAAGCTTTTGTTTTTTAAATGACTGAAGTGCTATAAATGTAGTCTGTTGCATTTTTAACCAACAGAACCCACAGTAGAGG
GGTCTCATGTCTCCCCAGTTCCACAGCAGTGTCACAGACGTGAAAGCCAGAACCTCAGAGGCCACTTGCTTGCTGACTTAGCCTCCTCCC
AAAGTCCCCCTCCTCAGCCAGCCTCCTTGTGAGAGTGGCTTTCTACCACACACAGCCTGTCCCTGGGGGAGTAATTCTGTCATTCCTAAA
ACACCCTTCAGCAATGATAATGAGCAGATGAGAGTTTCTGGATTAGCTTTTCCTATTTTCGATGAAGTTCTGAGATACTGAAATGTGAAA
AGAGCAATCAGAATTGTGCTTTTTCTCCCCTCCTCTATTCCTTTTAGGGAATAATATTCAATACACAGTACTTCCTCCCAGCATTGCTAC
TGCTCAGCTTCTTCTTTCATTCTAATCCTTGCTATTAAGAATTTAAGACTTGTGCTTACAATATTTTTGACCTGGAGTGGATCTATTTAC
ATAGTCATTTAGGATCCATGCAGCTTTTTTTGTCTTTTTAAGATTATTGGCTCATAAGCATATGTATACTGGTTTATGGAACTTTATTTA
CACTCCTCTATCATGCAAAAAAATTTTGACTTTTTAGTACTAAGCTTAATTTTTAAAAACAAAATCTGTAGGGTTGACAAATAAATAGTT
GCTCTTCTACACTAGGGGTTTCACCTGCAGGTTTGACACGCAGTTGCTCGCTTTTCCTGCCCTGTCAAGCTTCTCTGTTCTGGCGTGAGT
TGTGAAAGAGTTGAAGACAGCTTCCCATGCCGGTACACAGCCAGTAGCCTAAATCTCCAGTACTTGAGCTGACCATTGAACTAGGGCAAG
TCTTAAATGTGTACATGTAGTTGAATTTCAGTCCTTACGGGTAAACAGATTGAGCATGGCTCTCTATTCCCTCAGCCTAAGAAACACTCA
TGGGAATGCATTTGGCAACCCAAGGAACCATTTGCTTAAACCTGGAACATCTCACCTTTTTAAATCCTAAAAAACACTGGCAGTTATATT
TTAAATTAGTTTTTATTTTTATGATGGTTTTATCAAAAGACTTTTATTATTAGATTGGGACCCCCTTCAAACCTAAAAATCAAGTTATTT
CCTTTTATAATACTTTTCTTCCCCATGGAACAAATGGGATCAATTTGTGAGTTTTTTCCTTTAATGATAACTAAAATCCCTCTAATTTCT
CATTTATGCTTTTGTCTTTTTTATGAAATATTTCTTTTAAAAGCCCCAGTCTCACCTACGAAATATGAAGAGCAAAAGCTGATTTTGCTT
ACTTGCTAAACTGTTGGGAAAGCTCTGTAGAGCATGGTTCCAGTGAGGCCAAGATTGAAATTTGATACTAAAAAGGCCACCTAGCTTTTT
GCAGATAACAAACAAGAAAGCTATTCCAAGACTCAGATGATGCCAGCTGTCTCCCACGTGTGTATTATGGTTCACCAGGGGGAACTGGCA
AAAGTGTGTGTGGGGAGGGGAAGGGTGTGTGAGTGGTTCTGAGCAAATAACTACAGGGTGCCCATTACCACTCAAGAAGACACTTCACGT
ATTCTTGTATCAAATTCAATAATCTTAAACAATTTGTGTAGAAGTCCACAGACATCTTTCAACCACCTTTTAGGCTGCATATGGATTGCC
AAGTCAGCATATGAGGAATTAAAGACATTGTTTTTAAAAAAAAAAAATCATTTAGATGCACTTTTTTGTGTGTTCTTTAAATAAATCCAA

>In-frame_ENST00000398585_ENST00000536438_HM245389_TMPRSS2_chr21_42866283_-_FKBP5_chr6_35565187_length(amino acids)=411AA_start in transcript=40_stop in transcript=1275
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSIHLEGRCGGRMFDCRDVAFTVGEGEDHDIPIGIDKALEKMQREEQCILYLGPRYGFG
EAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFL
LAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDR

--------------------------------------------------------------
>In-frame_ENST00000398585_ENST00000357266_HM245389_TMPRSS2_chr21_42866283_-_FKBP5_chr6_35565187_length(transcript)=3521nt_BP=410nt
ACCAGGGTCCCGGCTCGGGGTCCGGGCTGGGGAGGGGAACCTGGGCGCCTGGGACCCGCCGATGCCCCCTGCCCCGCCCGGAGGTGAAAG
CGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTT
GAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGT
CCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCC
CGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAATCCACCTGGAAGGCCGCTGTGGTGGAAGGATGTTTGACTG
CAGAGATGTGGCATTCACTGTGGGCGAAGGAGAAGACCACGACATTCCAATTGGAATTGACAAAGCTCTGGAGAAAATGCAGCGGGAAGA
ACAATGTATTTTATATCTTGGACCAAGATATGGTTTTGGAGAGGCAGGGAAGCCTAAATTTGGCATTGAACCTAATGCTGAGCTTATATA
TGAAGTTACACTTAAGAGCTTCGAAAAGGCCAAAGAATCCTGGGAGATGGATACCAAAGAAAAATTGGAGCAGGCTGCCATTGTCAAAGA
GAAGGGAACCGTATACTTCAAGGGAGGCAAATACATGCAGGCGGTGATTCAGTATGGGAAGATAGTGTCCTGGTTAGAGATGGAATATGG
TTTATCAGAAAAGGAATCGAAAGCTTCTGAATCATTTCTCCTTGCTGCCTTTCTGAACCTGGCCATGTGCTACCTGAAGCTTAGAGAATA
CACCAAAGCTGTTGAATGCTGTGACAAGGCCCTTGGACTGGACAGTGCCAATGAGAAAGGCTTGTATAGGAGGGGTGAAGCCCAGCTGCT
CATGAACGAGTTTGAGTCAGCCAAGGGTGACTTTGAGAAAGTGCTGGAAGTAAACCCCCAGAATAAGGCTGCAAGACTGCAGATCTCCAT
GTGCCAGAAAAAGGCCAAGGAGCACAACGAGCGGGACCGCAGGATATACGCCAACATGTTCAAGAAGTTTGCAGAGCAGGATGCCAAGGA
AGAGGCCAATAAAGCAATGGGCAAGAAGACTTCAGAAGGGGTCACTAATGAAAAAGGAACAGACAGTCAAGCAATGGAAGAAGAGAAACC
TGAGGGCCACGTATGACGCCACGCCAAGGAGGGAAGAGTCCCAGTGAACTCGGCCCCTCCTCAATGGGCTTTCCCCCAACTCAGGACAGA
ACAGTGTTTAATGTAAAGTTTGTTATAGTCTATGTGATTCTGGAAGCAAATGGCAAAACCAGTAGCTTCCCAAAAACAGCCCCCCTGCTG
CTGCCCGGAGGGTTCACTGAGGGGTGGCACGGGACCACTCCAGGTGGAACAAACAGAAATGACTGTGGTGTGGAGGGAGTGAGCCAGCAG
CTTAAGTCCAGCTCATTTCAGTTTCTATCAACCTTCAAGTATCCAATTCAGGGTCCCTGGAGATCATCCTAACAATGTGGGGCTGTTAGG
TTTTACCTTTGAACTTTCATAGCACTGCAGAAACCTTTAAAAAAAAAATGCTTCATGAATTTCTCCTTTCCTACAGTTGGGTAGGGTAGG
GGAAGGAGGATAAGCTTTTGTTTTTTAAATGACTGAAGTGCTATAAATGTAGTCTGTTGCATTTTTAACCAACAGAACCCACAGTAGAGG
GGTCTCATGTCTCCCCAGTTCCACAGCAGTGTCACAGACGTGAAAGCCAGAACCTCAGAGGCCACTTGCTTGCTGACTTAGCCTCCTCCC
AAAGTCCCCCTCCTCAGCCAGCCTCCTTGTGAGAGTGGCTTTCTACCACACACAGCCTGTCCCTGGGGGAGTAATTCTGTCATTCCTAAA
ACACCCTTCAGCAATGATAATGAGCAGATGAGAGTTTCTGGATTAGCTTTTCCTATTTTCGATGAAGTTCTGAGATACTGAAATGTGAAA
AGAGCAATCAGAATTGTGCTTTTTCTCCCCTCCTCTATTCCTTTTAGGGAATAATATTCAATACACAGTACTTCCTCCCAGCATTGCTAC
TGCTCAGCTTCTTCTTTCATTCTAATCCTTGCTATTAAGAATTTAAGACTTGTGCTTACAATATTTTTGACCTGGAGTGGATCTATTTAC
ATAGTCATTTAGGATCCATGCAGCTTTTTTTGTCTTTTTAAGATTATTGGCTCATAAGCATATGTATACTGGTTTATGGAACTTTATTTA
CACTCCTCTATCATGCAAAAAAATTTTGACTTTTTAGTACTAAGCTTAATTTTTAAAAACAAAATCTGTAGGGTTGACAAATAAATAGTT
GCTCTTCTACACTAGGGGTTTCACCTGCAGGTTTGACACGCAGTTGCTCGCTTTTCCTGCCCTGTCAAGCTTCTCTGTTCTGGCGTGAGT
TGTGAAAGAGTTGAAGACAGCTTCCCATGCCGGTACACAGCCAGTAGCCTAAATCTCCAGTACTTGAGCTGACCATTGAACTAGGGCAAG
TCTTAAATGTGTACATGTAGTTGAATTTCAGTCCTTACGGGTAAACAGATTGAGCATGGCTCTCTATTCCCTCAGCCTAAGAAACACTCA
TGGGAATGCATTTGGCAACCCAAGGAACCATTTGCTTAAACCTGGAACATCTCACCTTTTTAAATCCTAAAAAACACTGGCAGTTATATT
TTAAATTAGTTTTTATTTTTATGATGGTTTTATCAAAAGACTTTTATTATTAGATTGGGACCCCCTTCAAACCTAAAAATCAAGTTATTT
CCTTTTATAATACTTTTCTTCCCCATGGAACAAATGGGATCAATTTGTGAGTTTTTTCCTTTAATGATAACTAAAATCCCTCTAATTTCT
CATTTATGCTTTTGTCTTTTTTATGAAATATTTCTTTTAAAAGCCCCAGTCTCACCTACGAAATATGAAGAGCAAAAGCTGATTTTGCTT
ACTTGCTAAACTGTTGGGAAAGCTCTGTAGAGCATGGTTCCAGTGAGGCCAAGATTGAAATTTGATACTAAAAAGGCCACCTAGCTTTTT
GCAGATAACAAACAAGAAAGCTATTCCAAGACTCAGATGATGCCAGCTGTCTCCCACGTGTGTATTATGGTTCACCAGGGGGAACTGGCA
AAAGTGTGTGTGGGGAGGGGAAGGGTGTGTGAGTGGTTCTGAGCAAATAACTACAGGGTGCCCATTACCACTCAAGAAGACACTTCACGT
ATTCTTGTATCAAATTCAATAATCTTAAACAATTTGTGTAGAAGTCCACAGACATCTTTCAACCACCTTTTAGGCTGCATATGGATTGCC
AAGTCAGCATATGAGGAATTAAAGACATTGTTTTTAAAAAAAAAAAATCATTTAGATGCACTTTTTTGTGTGTTCTTTAAATAAATCCAA

>In-frame_ENST00000398585_ENST00000357266_HM245389_TMPRSS2_chr21_42866283_-_FKBP5_chr6_35565187_length(amino acids)=411AA_start in transcript=40_stop in transcript=1275
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSIHLEGRCGGRMFDCRDVAFTVGEGEDHDIPIGIDKALEKMQREEQCILYLGPRYGFG
EAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFL
LAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TMPRSS2-FKBP5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMPRSS2-FKBP5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMPRSS2-FKBP5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMPRSS2C0033578Prostatic Neoplasms4CTD_human
HgeneTMPRSS2C0376358Malignant neoplasm of prostate4CTD_human
TgeneFKBP5C0005586Bipolar Disorder5PSYGENET
TgeneFKBP5C0011570Mental Depression5PSYGENET
TgeneFKBP5C0011581Depressive disorder5PSYGENET
TgeneFKBP5C0041696Unipolar Depression5PSYGENET
TgeneFKBP5C0525045Mood Disorders5PSYGENET
TgeneFKBP5C1269683Major Depressive Disorder5CTD_human;PSYGENET
TgeneFKBP5C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneFKBP5C0003873Rheumatoid Arthritis1CTD_human
TgeneFKBP5C0014175Endometriosis1CTD_human
TgeneFKBP5C0021290Neonatal disorder1CTD_human
TgeneFKBP5C0033975Psychotic Disorders1PSYGENET
TgeneFKBP5C0269102Endometrioma1CTD_human
TgeneFKBP5C0349204Nonorganic psychosis1PSYGENET
TgeneFKBP5C0525041Neurobehavioral Manifestations1CTD_human
TgeneFKBP5C2362914clinical depression1PSYGENET