|
Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:TMPRSS3-RSPH1 (FusionGDB2 ID:91771) |
Fusion Gene Summary for TMPRSS3-RSPH1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: TMPRSS3-RSPH1 | Fusion gene ID: 91771 | Hgene | Tgene | Gene symbol | TMPRSS3 | RSPH1 | Gene ID | 64699 | 89765 |
Gene name | transmembrane serine protease 3 | radial spoke head component 1 | |
Synonyms | DFNB10|DFNB8|ECHOS1|TADG12 | CT79|RSP44|RSPH10A|TSA2|TSGA2 | |
Cytomap | 21q22.3 | 21q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane protease serine 3serine protease TADG-12transmembrane protease, serine 3tumor-associated differentially-expressed gene 12 protein | radial spoke head 1 homologcancer/testis antigen 79male meiotic metaphase chromosome-associated acidic proteinmeichroacidintestes specific gene A2 homologtestis specific A2 homolog | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000474596, ENST00000398405, ENST00000433957, ENST00000291532, ENST00000380399, ENST00000398397, | ENST00000291536, ENST00000398352, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 2 X 2 X 2=8 |
# samples | 4 | 2 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: TMPRSS3 [Title/Abstract] AND RSPH1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | TMPRSS3(43795825)-RSPH1(43913189), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TMPRSS3 | GO:0006883 | cellular sodium ion homeostasis | 12393794 |
Fusion gene breakpoints across TMPRSS3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across RSPH1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LUAD | TCGA-44-4112-01A | TMPRSS3 | chr21 | 43795825 | - | RSPH1 | chr21 | 43913189 | - |
ChimerDB4 | LUAD | TCGA-44-4112-01A | TMPRSS3 | chr21 | 43795825 | - | RSPH1 | chr21 | 43913189 | - |
Top |
Fusion Gene ORF analysis for TMPRSS3-RSPH1 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000474596 | ENST00000291536 | TMPRSS3 | chr21 | 43795825 | - | RSPH1 | chr21 | 43913189 | - |
5UTR-intron | ENST00000474596 | ENST00000398352 | TMPRSS3 | chr21 | 43795825 | - | RSPH1 | chr21 | 43913189 | - |
In-frame | ENST00000398405 | ENST00000291536 | TMPRSS3 | chr21 | 43795825 | - | RSPH1 | chr21 | 43913189 | - |
5CDS-intron | ENST00000398405 | ENST00000398352 | TMPRSS3 | chr21 | 43795825 | - | RSPH1 | chr21 | 43913189 | - |
Frame-shift | ENST00000433957 | ENST00000291536 | TMPRSS3 | chr21 | 43795825 | - | RSPH1 | chr21 | 43913189 | - |
5CDS-intron | ENST00000433957 | ENST00000398352 | TMPRSS3 | chr21 | 43795825 | - | RSPH1 | chr21 | 43913189 | - |
Frame-shift | ENST00000291532 | ENST00000291536 | TMPRSS3 | chr21 | 43795825 | - | RSPH1 | chr21 | 43913189 | - |
5CDS-intron | ENST00000291532 | ENST00000398352 | TMPRSS3 | chr21 | 43795825 | - | RSPH1 | chr21 | 43913189 | - |
In-frame | ENST00000380399 | ENST00000291536 | TMPRSS3 | chr21 | 43795825 | - | RSPH1 | chr21 | 43913189 | - |
5CDS-intron | ENST00000380399 | ENST00000398352 | TMPRSS3 | chr21 | 43795825 | - | RSPH1 | chr21 | 43913189 | - |
intron-3CDS | ENST00000398397 | ENST00000291536 | TMPRSS3 | chr21 | 43795825 | - | RSPH1 | chr21 | 43913189 | - |
intron-intron | ENST00000398397 | ENST00000398352 | TMPRSS3 | chr21 | 43795825 | - | RSPH1 | chr21 | 43913189 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000398405 | TMPRSS3 | chr21 | 43795825 | - | ENST00000291536 | RSPH1 | chr21 | 43913189 | - | 3072 | 1864 | 160 | 2739 | 859 |
ENST00000380399 | TMPRSS3 | chr21 | 43795825 | - | ENST00000291536 | RSPH1 | chr21 | 43913189 | - | 3511 | 2303 | 701 | 3178 | 825 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000398405 | ENST00000291536 | TMPRSS3 | chr21 | 43795825 | - | RSPH1 | chr21 | 43913189 | - | 0.000508765 | 0.9994912 |
ENST00000380399 | ENST00000291536 | TMPRSS3 | chr21 | 43795825 | - | RSPH1 | chr21 | 43913189 | - | 0.000798056 | 0.99920195 |
Top |
Fusion Genomic Features for TMPRSS3-RSPH1 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for TMPRSS3-RSPH1 |
Go to FGviewer for the breakpoints of chr21:43795825-chr21:43913189 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000291532 | - | 12 | 13 | 109_205 | 449.0 | 455.0 | Domain | SRCR |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000291532 | - | 12 | 13 | 217_449 | 449.0 | 455.0 | Domain | Peptidase S1 |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000291532 | - | 12 | 13 | 72_108 | 449.0 | 455.0 | Domain | LDL-receptor class A |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000380399 | - | 12 | 13 | 109_205 | 533.0 | 539.0 | Domain | SRCR |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000380399 | - | 12 | 13 | 217_449 | 533.0 | 539.0 | Domain | Peptidase S1 |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000380399 | - | 12 | 13 | 72_108 | 533.0 | 539.0 | Domain | LDL-receptor class A |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000433957 | - | 12 | 13 | 109_205 | 448.0 | 454.0 | Domain | SRCR |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000433957 | - | 12 | 13 | 217_449 | 448.0 | 454.0 | Domain | Peptidase S1 |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000433957 | - | 12 | 13 | 72_108 | 448.0 | 454.0 | Domain | LDL-receptor class A |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000291532 | - | 12 | 13 | 1_48 | 449.0 | 455.0 | Topological domain | Cytoplasmic |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000380399 | - | 12 | 13 | 1_48 | 533.0 | 539.0 | Topological domain | Cytoplasmic |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000380399 | - | 12 | 13 | 70_454 | 533.0 | 539.0 | Topological domain | Extracellular |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000433957 | - | 12 | 13 | 1_48 | 448.0 | 454.0 | Topological domain | Cytoplasmic |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000291532 | - | 12 | 13 | 49_69 | 449.0 | 455.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000380399 | - | 12 | 13 | 49_69 | 533.0 | 539.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000433957 | - | 12 | 13 | 49_69 | 448.0 | 454.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Tgene | RSPH1 | chr21:43795825 | chr21:43913189 | ENST00000291536 | 0 | 9 | 195_201 | 18.0 | 310.0 | Compositional bias | Note=Poly-Glu | |
Tgene | RSPH1 | chr21:43795825 | chr21:43913189 | ENST00000291536 | 0 | 9 | 298_301 | 18.0 | 310.0 | Compositional bias | Note=Poly-Glu | |
Tgene | RSPH1 | chr21:43795825 | chr21:43913189 | ENST00000291536 | 0 | 9 | 113_135 | 18.0 | 310.0 | Repeat | Note=MORN 5 | |
Tgene | RSPH1 | chr21:43795825 | chr21:43913189 | ENST00000291536 | 0 | 9 | 159_181 | 18.0 | 310.0 | Repeat | Note=MORN 6 | |
Tgene | RSPH1 | chr21:43795825 | chr21:43913189 | ENST00000291536 | 0 | 9 | 20_43 | 18.0 | 310.0 | Repeat | Note=MORN 1 | |
Tgene | RSPH1 | chr21:43795825 | chr21:43913189 | ENST00000291536 | 0 | 9 | 44_66 | 18.0 | 310.0 | Repeat | Note=MORN 2 | |
Tgene | RSPH1 | chr21:43795825 | chr21:43913189 | ENST00000291536 | 0 | 9 | 67_89 | 18.0 | 310.0 | Repeat | Note=MORN 3 | |
Tgene | RSPH1 | chr21:43795825 | chr21:43913189 | ENST00000291536 | 0 | 9 | 90_112 | 18.0 | 310.0 | Repeat | Note=MORN 4 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000398397 | - | 1 | 9 | 109_205 | 0 | 345.0 | Domain | SRCR |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000398397 | - | 1 | 9 | 217_449 | 0 | 345.0 | Domain | Peptidase S1 |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000398397 | - | 1 | 9 | 72_108 | 0 | 345.0 | Domain | LDL-receptor class A |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000291532 | - | 12 | 13 | 70_454 | 449.0 | 455.0 | Topological domain | Extracellular |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000398397 | - | 1 | 9 | 1_48 | 0 | 345.0 | Topological domain | Cytoplasmic |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000398397 | - | 1 | 9 | 70_454 | 0 | 345.0 | Topological domain | Extracellular |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000433957 | - | 12 | 13 | 70_454 | 448.0 | 454.0 | Topological domain | Extracellular |
Hgene | TMPRSS3 | chr21:43795825 | chr21:43913189 | ENST00000398397 | - | 1 | 9 | 49_69 | 0 | 345.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Top |
Fusion Gene Sequence for TMPRSS3-RSPH1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000398405_ENST00000291536_TCGA-44-4112-01A_TMPRSS3_chr21_43795825_-_RSPH1_chr21_43913189_length(transcript)=3072nt_BP=1864nt ATGTGAGTACCGAAACTACTTATGCTTATGGTAGGTGTACCACACGCACAGGGAAAGAATTGCGTTTATGTGGGACAGGTGAAAACAATC GCAAAAAAGCAATGGAAAGGGCTTTGAGAGTAATTTATCTTCTGAACAATAGCAATATGGCAACTTCTAAATGGTGAGAGGGAGTCCCTC TAAAGCAATCGATTTGAAGATTGGTTGGACAAACAATGGGAAAGTCATTGTCTTAGCAGAATTAAGTTCATACTTTTTTTTTTTTTTTTT TTTTGCTAATTCTAGAAGCTTTTCTGTTATCTGCTGTAGCTCAGACGAAAATGCATTCTCACCAGATGACTGTTTTTGGTTAATCGATAC TGAATGCGCTTTGTGTGGACTGTCGAATTTCAAAGATTTACCGTATGACCAAGATGCACCTGATGCTACAAGTATAAATAGGGGAACAAA TGCTTTCTGTTCTTCCTCGGCTAAGGAGGTAGAGGTGGAGGCGGAGCCGGATGTCAGAGGTCCTGAAATAGTCACCATGGGGGAAAATGA TCCGCCTGCTGTTGAAGCCCCCTTCTCATTCCGATCGCTTTTTGGCCTTGATGATTTGAAAATAAGTCCTGTTGCACCAGATGCTGTTGC TGCACAGATCCTGTCACTGCTGCCATTGAAGTTTTTTCCAATCATCGTCATTGGGATCATTGCATTGATATTAGCACTGGCCATTGGTCT GGGCATCCACTTCGACTGCTCAGGGAAGTACAGATGTCGCTCATCCTTTAAGTGTATCGAGCTGATAGCTCGATGTGACGGAGTCTCGGA TTGCAAAGACGGGGAGGACGAGTACCGCTGTGTCCGGGTGGGTGGTCAGAATGCCGTGCTCCAGGTGTTCACAGCTGCTTCGTGGAAGAC CATGTGCTCCGATGACTGGAAGGGTCACTACGCAAATGTTGCCTGTGCCCAACTGGGTTTCCCAAGCTATGTGAGTTCAGATAACCTCAG AGTGAGCTCGCTGGAGGGGCAGTTCCGGGAGGAGTTTGTGTCCATCGATCACCTCTTGCCAGATGACAAGGTGACTGCATTACACCACTC AGTATATGTGAGGGAGGGATGTGCCTCTGGCCACGTGGTTACCTTGCAGTGCACAGCCTGTGGTCATAGAAGGGGCTACAGCTCACGCAT CGTGGGTGGAAACATGTCCTTGCTCTCGCAGTGGCCCTGGCAGGCCAGCCTTCAGTTCCAGGGCTACCACCTGTGCGGGGGCTCTGTCAT CACGCCCCTGTGGATCATCACTGCTGCACACTGTGTTTATGACTTGTACCTCCCCAAGTCATGGACCATCCAGGTGGGTCTAGTTTCCCT GTTGGACAATCCAGCCCCATCCCACTTGGTGGAGAAGATTGTCTACCACAGCAAGTACAAGCCAAAGAGGCTGGGCAATGACATCGCCCT TATGAAGCTGGCCGGGCCACTCACGTTCAATGAAATGATCCAGCCTGTGTGCCTGCCCAACTCTGAAGAGAACTTCCCCGATGGAAAAGT GTGCTGGACGTCAGGATGGGGGGCCACAGAGGATGGAGGTGACGCCTCCCCTGTCCTGAACCACGCGGCCGTCCCTTTGATTTCCAACAA GATCTGCAACCACAGGGACGTGTACGGTGGCATCATCTCCCCCTCCATGCTCTGCGCGGGCTACCTGACGGGTGGCGTGGACAGCTGCCA GGGGGACAGCGGGGGGCCCCTGGTGTGTCAAGAGAGGAGGCTGTGGAAGTTAGTGGGAGCGACCAGCTTTGGCATCGGCTGCGCAGAGGT GAACAAGCCTGGGGTGTACACCCGTGTCACCTCCTTCCTGGACTGGATCCACGAGCAGATGGAGGAATATGAGGGGGGTCGGAATGAGGC AGGCGAAAGGCACGGACGTGGGAGGGCACGGCTACCCAACGGGGACACCTACGAAGGGAGCTACGAATTCGGTAAAAGACATGGCCAGGG GATCTACAAATTTAAAAATGGTGCTCGATATATCGGAGAATATGTTAGAAATAAAAAGCACGGTCAAGGCACTTTTATATATCCAGATGG ATCCAGATATGAAGGAGAGTGGGCAAATGACCTGCGGCACGGCCATGGCGTATACTACTACATCAATAATGACACCTACACTGGAGAGTG GTTTGCTCATCAAAGGCATGGGCAAGGCACCTATTTATACGCGGAGACGGGCAGTAAGTATGTTGGCACCTGGGTGAACGGACAGCAGGA GGGCACGGCCGAGCTCATTCACCTGAACCACAGGTACCAGGGCAAGTTCTTGAACAAAAATCCTGTTGGCCCTGGAAAGTATGTATTTGA TGTTGGGTGTGAACAACATGGTGAATATCGTTTAACAGATATGGAAAGAGGAGAAGAGGAAGAGGAGGAAGAATTAGTAACTGTTGTTCC AAAATGGAAAGCTACCCAAATCACTGAATTGGCCCTGTGGACACCAACTCTCCCCAAAAAGCCGACCTCTACGGATGGACCTGGCCAAGA CGCTCCAGGAGCTGAGAGTGCAGGAGAACCCGGGGAGGAGGCCCAGGCTCTGCTGGAGGGCTTCGAGGGTGAGATGGACATGAGGCCTGG AGATGAAGATGCAGACGTCCTCCGGGAAGAGAGCCGGGAGTATGACCAGGAGGAGTTCCGCTATGACATGGATGAGGGAAACATTAATTC TGAAGAAGAAGAAACTAGACAGTCAGACCTCCAGGACTAAGATGAAGTGAGCCGAGAGGAGATCGTATCATAAGAATGCTTCTGTCGTTA GCCGGGTGCAGTGCTGTGTGTATCTAGTTCCAGCTACTTGAGAGGCTGAGGCAGGAGGATTGCTTGAGTCCAGAAAGTGGCAGTTGCAGT GAGTGGAGATCGCGCCACTGCTCTCCAGCCTGGGTGGCAGAGCGAGACCCTGTCTCAAAAAATAAACAAAAACAAAATGCTTCTGTCAGT TAACAATCTTTATTAGAGGGTTTTTAGTCTTTCTTTCTCAGCTGTATGTTAAGTTGATTGACAAATGCAAATAAACGTCTTTATTATCCT >In-frame_ENST00000398405_ENST00000291536_TCGA-44-4112-01A_TMPRSS3_chr21_43795825_-_RSPH1_chr21_43913189_length(amino acids)=859AA_start in transcript=160_stop in transcript=2739 MVRGSPSKAIDLKIGWTNNGKVIVLAELSSYFFFFFFFANSRSFSVICCSSDENAFSPDDCFWLIDTECALCGLSNFKDLPYDQDAPDAT SINRGTNAFCSSSAKEVEVEAEPDVRGPEIVTMGENDPPAVEAPFSFRSLFGLDDLKISPVAPDAVAAQILSLLPLKFFPIIVIGIIALI LALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCSDDWKGHYANVACAQLGFPSY VSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYH LCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEE NFPDGKVCWTSGWGATEDGGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSF GIGCAEVNKPGVYTRVTSFLDWIHEQMEEYEGGRNEAGERHGRGRARLPNGDTYEGSYEFGKRHGQGIYKFKNGARYIGEYVRNKKHGQG TFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLYAETGSKYVGTWVNGQQEGTAELIHLNHRYQGKFLNKNPVG PGKYVFDVGCEQHGEYRLTDMERGEEEEEEELVTVVPKWKATQITELALWTPTLPKKPTSTDGPGQDAPGAESAGEPGEEAQALLEGFEG -------------------------------------------------------------- >In-frame_ENST00000380399_ENST00000291536_TCGA-44-4112-01A_TMPRSS3_chr21_43795825_-_RSPH1_chr21_43913189_length(transcript)=3511nt_BP=2303nt TTCTGCTTTTAATGATGGCAGCTCCAGAAATGGTGAGTAAAATGGGTGTGAGGAGAGAAGATGCTTCTCAACACTTCTCAGTGTTGTACA GCTTGCCAACCACAGCCTGTTTGGGAGGGGATGTTCTCACCCAGGTTCCATCTTTCAGAAGCCATTTGCCCACTTATTCTTTTTATATGG ATAAACGATGTAATTTGCTACATGCTGATAATAAACAGAGGTATCAGCAAGAATGAAAGCCAGAAAATGGCCCAACATGAACTTCTTGCT TTTCTAAGTTACTCTTTCAAGCTCTTCTTGCGATAGAAATGAAATGAACATTTTTGGCACAGAACTCTTGTTTAGATTTTACTATGATCT TGGGAAACACGGGTTGCTTCAAATGGCTTACTAGATCCCTTTGGAATTTCAAACGTTACAACAGGTAGTCACAAAGGGAATGAAAGCGGA TGATCTGAGTGTCTGTGCTGATGTGCCTGCTGGAGCCCCTGTGGATTTTAGCCCTTGGAGGAAGCAGGTTCCCAGAGCAGCCATGCCTGA TATCTGGGAGAGGGAACTAGAATTTAATTGGGAATCTTCTGCTATTTCCCTGCTTCCTCCGCCCTCTCAGAGTTACAGGGAATGACTTAG AAAGGTCTCTGGTCTCCTTGGCATTGTGATAGGTGGAATTCTTTCGTAGGAAACACAGCCCCGGGGTTATTTTGATGCAAGCCGTTGGTC CAAAGCCACTCCCCACTTTGCTATGTGGGGGAAGGACCGGGCACCGGACGGCTCGGGTACTTTCGTTCTTAATTAGGTCATGCCCGTGTG AGCCAGGAAAGGGCTGTGTTTATGGGAAGCCAGTAACACTGTGGCCTACTATCTCTTCCGTGGTGCCATCTACATTTTTGGGACTCGGGA ATTATGAGGTAGAGGTGGAGGCGGAGCCGGATGTCAGAGGTCCTGAAATAGTCACCATGGGGGAAAATGATCCGCCTGCTGTTGAAGCCC CCTTCTCATTCCGATCGCTTTTTGGCCTTGATGATTTGAAAATAAGTCCTGTTGCACCAGATGCAGATGCTGTTGCTGCACAGATCCTGT CACTGCTGCCATTGAAGTTTTTTCCAATCATCGTCATTGGGATCATTGCATTGATATTAGCACTGGCCATTGGTCTGGGCATCCACTTCG ACTGCTCAGGGAAGTACAGATGTCGCTCATCCTTTAAGTGTATCGAGCTGATAGCTCGATGTGACGGAGTCTCGGATTGCAAAGACGGGG AGGACGAGTACCGCTGTGTCCGGGTGGGTGGTCAGAATGCCGTGCTCCAGGTGTTCACAGCTGCTTCGTGGAAGACCATGTGCTCCGATG ACTGGAAGGGTCACTACGCAAATGTTGCCTGTGCCCAACTGGGTTTCCCAAGCTATGTGAGTTCAGATAACCTCAGAGTGAGCTCGCTGG AGGGGCAGTTCCGGGAGGAGTTTGTGTCCATCGATCACCTCTTGCCAGATGACAAGGTGACTGCATTACACCACTCAGTATATGTGAGGG AGGGATGTGCCTCTGGCCACGTGGTTACCTTGCAGTGCACAGCCTGTGGTCATAGAAGGGGCTACAGCTCACGCATCGTGGGTGGAAACA TGTCCTTGCTCTCGCAGTGGCCCTGGCAGGCCAGCCTTCAGTTCCAGGGCTACCACCTGTGCGGGGGCTCTGTCATCACGCCCCTGTGGA TCATCACTGCTGCACACTGTGTTTATGACTTGTACCTCCCCAAGTCATGGACCATCCAGGTGGGTCTAGTTTCCCTGTTGGACAATCCAG CCCCATCCCACTTGGTGGAGAAGATTGTCTACCACAGCAAGTACAAGCCAAAGAGGCTGGGCAATGACATCGCCCTTATGAAGCTGGCCG GGCCACTCACGTTCAATGAAATGATCCAGCCTGTGTGCCTGCCCAACTCTGAAGAGAACTTCCCCGATGGAAAAGTGTGCTGGACGTCAG GATGGGGGGCCACAGAGGATGGAGCAGGTGACGCCTCCCCTGTCCTGAACCACGCGGCCGTCCCTTTGATTTCCAACAAGATCTGCAACC ACAGGGACGTGTACGGTGGCATCATCTCCCCCTCCATGCTCTGCGCGGGCTACCTGACGGGTGGCGTGGACAGCTGCCAGGGGGACAGCG GGGGGCCCCTGGTGTGTCAAGAGAGGAGGCTGTGGAAGTTAGTGGGAGCGACCAGCTTTGGCATCGGCTGCGCAGAGGTGAACAAGCCTG GGGTGTACACCCGTGTCACCTCCTTCCTGGACTGGATCCACGAGCAGATGGAGGAATATGAGGGGGGTCGGAATGAGGCAGGCGAAAGGC ACGGACGTGGGAGGGCACGGCTACCCAACGGGGACACCTACGAAGGGAGCTACGAATTCGGTAAAAGACATGGCCAGGGGATCTACAAAT TTAAAAATGGTGCTCGATATATCGGAGAATATGTTAGAAATAAAAAGCACGGTCAAGGCACTTTTATATATCCAGATGGATCCAGATATG AAGGAGAGTGGGCAAATGACCTGCGGCACGGCCATGGCGTATACTACTACATCAATAATGACACCTACACTGGAGAGTGGTTTGCTCATC AAAGGCATGGGCAAGGCACCTATTTATACGCGGAGACGGGCAGTAAGTATGTTGGCACCTGGGTGAACGGACAGCAGGAGGGCACGGCCG AGCTCATTCACCTGAACCACAGGTACCAGGGCAAGTTCTTGAACAAAAATCCTGTTGGCCCTGGAAAGTATGTATTTGATGTTGGGTGTG AACAACATGGTGAATATCGTTTAACAGATATGGAAAGAGGAGAAGAGGAAGAGGAGGAAGAATTAGTAACTGTTGTTCCAAAATGGAAAG CTACCCAAATCACTGAATTGGCCCTGTGGACACCAACTCTCCCCAAAAAGCCGACCTCTACGGATGGACCTGGCCAAGACGCTCCAGGAG CTGAGAGTGCAGGAGAACCCGGGGAGGAGGCCCAGGCTCTGCTGGAGGGCTTCGAGGGTGAGATGGACATGAGGCCTGGAGATGAAGATG CAGACGTCCTCCGGGAAGAGAGCCGGGAGTATGACCAGGAGGAGTTCCGCTATGACATGGATGAGGGAAACATTAATTCTGAAGAAGAAG AAACTAGACAGTCAGACCTCCAGGACTAAGATGAAGTGAGCCGAGAGGAGATCGTATCATAAGAATGCTTCTGTCGTTAGCCGGGTGCAG TGCTGTGTGTATCTAGTTCCAGCTACTTGAGAGGCTGAGGCAGGAGGATTGCTTGAGTCCAGAAAGTGGCAGTTGCAGTGAGTGGAGATC GCGCCACTGCTCTCCAGCCTGGGTGGCAGAGCGAGACCCTGTCTCAAAAAATAAACAAAAACAAAATGCTTCTGTCAGTTAACAATCTTT ATTAGAGGGTTTTTAGTCTTTCTTTCTCAGCTGTATGTTAAGTTGATTGACAAATGCAAATAAACGTCTTTATTATCCTTTCTTTCTGAA >In-frame_ENST00000380399_ENST00000291536_TCGA-44-4112-01A_TMPRSS3_chr21_43795825_-_RSPH1_chr21_43913189_length(amino acids)=825AA_start in transcript=701_stop in transcript=3178 MMQAVGPKPLPTLLCGGRTGHRTARVLSFLIRSCPCEPGKGCVYGKPVTLWPTISSVVPSTFLGLGNYEVEVEAEPDVRGPEIVTMGEND PPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGV SDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALH HSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLV SLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLI SNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMEEYEGGR NEAGERHGRGRARLPNGDTYEGSYEFGKRHGQGIYKFKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYT GEWFAHQRHGQGTYLYAETGSKYVGTWVNGQQEGTAELIHLNHRYQGKFLNKNPVGPGKYVFDVGCEQHGEYRLTDMERGEEEEEEELVT VVPKWKATQITELALWTPTLPKKPTSTDGPGQDAPGAESAGEPGEEAQALLEGFEGEMDMRPGDEDADVLREESREYDQEEFRYDMDEGN -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for TMPRSS3-RSPH1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for TMPRSS3-RSPH1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for TMPRSS3-RSPH1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TMPRSS3 | C3711374 | Nonsyndromic Deafness | 8 | CLINGEN |
Hgene | TMPRSS3 | C1832827 | DEAFNESS, CHILDHOOD-ONSET NEUROSENSORY, AUTOSOMAL RECESSIVE 8 | 7 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | TMPRSS3 | C0004681 | Bagassosis | 1 | CTD_human |
Hgene | TMPRSS3 | C0032273 | Pneumoconiosis | 1 | CTD_human |
Hgene | TMPRSS3 | C1384666 | hearing impairment | 1 | GENOMICS_ENGLAND |
Tgene | RSPH1 | C3809634 | CILIARY DYSKINESIA, PRIMARY, 24 | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | RSPH1 | C0022521 | Kartagener Syndrome | 1 | ORPHANET |
Tgene | RSPH1 | C4317124 | Polynesian Bronchiectasis | 1 | ORPHANET |
Tgene | RSPH1 | C4551720 | Primary Ciliary Dyskinesia | 1 | ORPHANET |
Tgene | RSPH1 | C4551906 | Ciliary Dyskinesia, Primary, 1, With Or Without Situs Inversus | 1 | ORPHANET |