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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TNC-TNC (FusionGDB2 ID:91945)

Fusion Gene Summary for TNC-TNC

Fusion gene summary

Fusion gene information	Fusion gene name: TNC-TNC
	Fusion gene ID: 91945
		Hgene	Tgene
	Gene symbol	TNC	TNC
	Gene ID	7134	7134
	Gene name	troponin C1, slow skeletal and cardiac type	troponin C1, slow skeletal and cardiac type
	Synonyms	CMD1Z\|CMH13\|TN-C\|TNC\|TNNC	CMD1Z\|CMH13\|TN-C\|TNC\|TNNC
	Cytomap	3p21.1	3p21.1
	Type of gene	protein-coding	protein-coding
	Description	troponin C, slow skeletal and cardiac musclescardiac troponin Cslow twitch skeletal/cardiac muscle troponin Ctroponin C type 1 (slow)	troponin C, slow skeletal and cardiac musclescardiac troponin Cslow twitch skeletal/cardiac muscle troponin Ctroponin C type 1 (slow)
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000535648, ENST00000346706, ENST00000340094, ENST00000345230, ENST00000350763, ENST00000341037, ENST00000423613, ENST00000537320, ENST00000542877, ENST00000481475,	ENST00000535648, ENST00000346706, ENST00000340094, ENST00000345230, ENST00000350763, ENST00000341037, ENST00000423613, ENST00000537320, ENST00000542877, ENST00000481475,
Fusion gene scores	* DoF score	6 X 9 X 3=162	8 X 8 X 4=256
	# samples	8	11
	** MAII score	log2(8/162*10)=-1.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/256*10)=-1.21864028647534 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TNC [Title/Abstract] AND TNC [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TNC(117786353)-TNC(117793891), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TNC	GO:0006937	regulation of muscle contraction	18092822
Hgene	TNC	GO:0060048	cardiac muscle contraction	25771144
Tgene	TNC	GO:0006937	regulation of muscle contraction	18092822
Tgene	TNC	GO:0060048	cardiac muscle contraction	25771144

Fusion gene breakpoints across TNC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TNC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BF770933	TNC	chr9	117786353	-	TNC	chr9	117793891	-
ChiTaRS5.0	N/A	BF770941	TNC	chr9	117786353	-	TNC	chr9	117793891	-
ChiTaRS5.0	N/A	AW993656	TNC	chr9	117822036	+	TNC	chr9	117825405	-
ChiTaRS5.0	N/A	BF341315	TNC	chr9	117783381	+	TNC	chr9	117783330	-

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Fusion Gene ORF analysis for TNC-TNC

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000535648	ENST00000535648	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000535648	ENST00000346706	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000535648	ENST00000340094	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000535648	ENST00000345230	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000535648	ENST00000350763	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000535648	ENST00000341037	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000535648	ENST00000423613	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000535648	ENST00000537320	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000535648	ENST00000542877	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-intron	ENST00000535648	ENST00000481475	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000346706	ENST00000535648	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000346706	ENST00000346706	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000346706	ENST00000340094	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000346706	ENST00000345230	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000346706	ENST00000350763	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000346706	ENST00000341037	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000346706	ENST00000423613	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000346706	ENST00000537320	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000346706	ENST00000542877	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-intron	ENST00000346706	ENST00000481475	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000340094	ENST00000535648	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000340094	ENST00000346706	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000340094	ENST00000340094	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000340094	ENST00000345230	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000340094	ENST00000350763	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000340094	ENST00000341037	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000340094	ENST00000423613	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000340094	ENST00000537320	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000340094	ENST00000542877	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-intron	ENST00000340094	ENST00000481475	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000345230	ENST00000535648	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000345230	ENST00000346706	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000345230	ENST00000340094	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000345230	ENST00000345230	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000345230	ENST00000350763	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000345230	ENST00000341037	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000345230	ENST00000423613	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000345230	ENST00000537320	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000345230	ENST00000542877	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-intron	ENST00000345230	ENST00000481475	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000350763	ENST00000535648	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000350763	ENST00000346706	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000350763	ENST00000340094	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000350763	ENST00000345230	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000350763	ENST00000350763	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000350763	ENST00000341037	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000350763	ENST00000423613	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000350763	ENST00000537320	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000350763	ENST00000542877	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-intron	ENST00000350763	ENST00000481475	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000341037	ENST00000535648	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000341037	ENST00000346706	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000341037	ENST00000340094	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000341037	ENST00000345230	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000341037	ENST00000350763	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000341037	ENST00000341037	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000341037	ENST00000423613	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000341037	ENST00000537320	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000341037	ENST00000542877	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-intron	ENST00000341037	ENST00000481475	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000423613	ENST00000535648	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000423613	ENST00000346706	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000423613	ENST00000340094	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000423613	ENST00000345230	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000423613	ENST00000350763	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000423613	ENST00000341037	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000423613	ENST00000423613	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000423613	ENST00000537320	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000423613	ENST00000542877	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-intron	ENST00000423613	ENST00000481475	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000537320	ENST00000535648	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000537320	ENST00000346706	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000537320	ENST00000340094	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000537320	ENST00000345230	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000537320	ENST00000350763	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000537320	ENST00000341037	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000537320	ENST00000423613	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000537320	ENST00000537320	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000537320	ENST00000542877	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-intron	ENST00000537320	ENST00000481475	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000542877	ENST00000535648	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000542877	ENST00000346706	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000542877	ENST00000340094	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000542877	ENST00000345230	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000542877	ENST00000350763	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000542877	ENST00000341037	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000542877	ENST00000423613	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000542877	ENST00000537320	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000542877	ENST00000542877	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-intron	ENST00000542877	ENST00000481475	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000481475	ENST00000535648	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000481475	ENST00000346706	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000481475	ENST00000340094	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000481475	ENST00000345230	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000481475	ENST00000350763	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000481475	ENST00000341037	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000481475	ENST00000423613	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000481475	ENST00000537320	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-3CDS	ENST00000481475	ENST00000542877	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-intron	ENST00000481475	ENST00000481475	TNC	chr9	117786353	-	TNC	chr9	117793891	-
intron-intron	ENST00000535648	ENST00000535648	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000535648	ENST00000346706	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000535648	ENST00000340094	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000535648	ENST00000345230	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000535648	ENST00000350763	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000535648	ENST00000341037	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000535648	ENST00000423613	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000535648	ENST00000537320	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000535648	ENST00000542877	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000535648	ENST00000481475	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000346706	ENST00000535648	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000346706	ENST00000346706	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000346706	ENST00000340094	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000346706	ENST00000345230	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000346706	ENST00000350763	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000346706	ENST00000341037	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000346706	ENST00000423613	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000346706	ENST00000537320	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000346706	ENST00000542877	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000346706	ENST00000481475	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000340094	ENST00000535648	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000340094	ENST00000346706	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000340094	ENST00000340094	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000340094	ENST00000345230	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000340094	ENST00000350763	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000340094	ENST00000341037	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000340094	ENST00000423613	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000340094	ENST00000537320	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000340094	ENST00000542877	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000340094	ENST00000481475	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000345230	ENST00000535648	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000345230	ENST00000346706	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000345230	ENST00000340094	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000345230	ENST00000345230	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000345230	ENST00000350763	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000345230	ENST00000341037	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000345230	ENST00000423613	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000345230	ENST00000537320	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000345230	ENST00000542877	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000345230	ENST00000481475	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000350763	ENST00000535648	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000350763	ENST00000346706	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000350763	ENST00000340094	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000350763	ENST00000345230	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000350763	ENST00000350763	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000350763	ENST00000341037	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000350763	ENST00000423613	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000350763	ENST00000537320	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000350763	ENST00000542877	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000350763	ENST00000481475	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000341037	ENST00000535648	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000341037	ENST00000346706	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000341037	ENST00000340094	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000341037	ENST00000345230	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000341037	ENST00000350763	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000341037	ENST00000341037	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000341037	ENST00000423613	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000341037	ENST00000537320	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000341037	ENST00000542877	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000341037	ENST00000481475	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000423613	ENST00000535648	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000423613	ENST00000346706	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000423613	ENST00000340094	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000423613	ENST00000345230	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000423613	ENST00000350763	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000423613	ENST00000341037	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000423613	ENST00000423613	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000423613	ENST00000537320	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000423613	ENST00000542877	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000423613	ENST00000481475	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000537320	ENST00000535648	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000537320	ENST00000346706	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000537320	ENST00000340094	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000537320	ENST00000345230	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000537320	ENST00000350763	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000537320	ENST00000341037	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000537320	ENST00000423613	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000537320	ENST00000537320	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000537320	ENST00000542877	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000537320	ENST00000481475	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000542877	ENST00000535648	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000542877	ENST00000346706	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000542877	ENST00000340094	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000542877	ENST00000345230	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000542877	ENST00000350763	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000542877	ENST00000341037	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000542877	ENST00000423613	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000542877	ENST00000537320	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000542877	ENST00000542877	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000542877	ENST00000481475	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000481475	ENST00000535648	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000481475	ENST00000346706	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000481475	ENST00000340094	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000481475	ENST00000345230	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000481475	ENST00000350763	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000481475	ENST00000341037	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000481475	ENST00000423613	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000481475	ENST00000537320	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000481475	ENST00000542877	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-intron	ENST00000481475	ENST00000481475	TNC	chr9	117822036	+	TNC	chr9	117825405	-
intron-3UTR	ENST00000535648	ENST00000535648	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000535648	ENST00000346706	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000535648	ENST00000340094	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000535648	ENST00000345230	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000535648	ENST00000350763	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000535648	ENST00000341037	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000535648	ENST00000423613	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000535648	ENST00000537320	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-intron	ENST00000535648	ENST00000542877	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-intron	ENST00000535648	ENST00000481475	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000346706	ENST00000535648	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000346706	ENST00000346706	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000346706	ENST00000340094	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000346706	ENST00000345230	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000346706	ENST00000350763	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000346706	ENST00000341037	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000346706	ENST00000423613	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000346706	ENST00000537320	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-intron	ENST00000346706	ENST00000542877	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-intron	ENST00000346706	ENST00000481475	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000340094	ENST00000535648	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000340094	ENST00000346706	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000340094	ENST00000340094	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000340094	ENST00000345230	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000340094	ENST00000350763	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000340094	ENST00000341037	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000340094	ENST00000423613	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000340094	ENST00000537320	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-intron	ENST00000340094	ENST00000542877	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-intron	ENST00000340094	ENST00000481475	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000345230	ENST00000535648	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000345230	ENST00000346706	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000345230	ENST00000340094	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000345230	ENST00000345230	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000345230	ENST00000350763	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000345230	ENST00000341037	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000345230	ENST00000423613	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000345230	ENST00000537320	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-intron	ENST00000345230	ENST00000542877	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-intron	ENST00000345230	ENST00000481475	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000350763	ENST00000535648	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000350763	ENST00000346706	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000350763	ENST00000340094	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000350763	ENST00000345230	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000350763	ENST00000350763	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000350763	ENST00000341037	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000350763	ENST00000423613	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000350763	ENST00000537320	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-intron	ENST00000350763	ENST00000542877	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-intron	ENST00000350763	ENST00000481475	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000341037	ENST00000535648	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000341037	ENST00000346706	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000341037	ENST00000340094	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000341037	ENST00000345230	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000341037	ENST00000350763	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000341037	ENST00000341037	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000341037	ENST00000423613	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000341037	ENST00000537320	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-intron	ENST00000341037	ENST00000542877	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-intron	ENST00000341037	ENST00000481475	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000423613	ENST00000535648	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000423613	ENST00000346706	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000423613	ENST00000340094	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000423613	ENST00000345230	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000423613	ENST00000350763	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000423613	ENST00000341037	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000423613	ENST00000423613	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000423613	ENST00000537320	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-intron	ENST00000423613	ENST00000542877	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-intron	ENST00000423613	ENST00000481475	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000537320	ENST00000535648	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000537320	ENST00000346706	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000537320	ENST00000340094	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000537320	ENST00000345230	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000537320	ENST00000350763	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000537320	ENST00000341037	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000537320	ENST00000423613	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000537320	ENST00000537320	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-intron	ENST00000537320	ENST00000542877	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-intron	ENST00000537320	ENST00000481475	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000542877	ENST00000535648	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000542877	ENST00000346706	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000542877	ENST00000340094	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000542877	ENST00000345230	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000542877	ENST00000350763	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000542877	ENST00000341037	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000542877	ENST00000423613	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000542877	ENST00000537320	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-intron	ENST00000542877	ENST00000542877	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-intron	ENST00000542877	ENST00000481475	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000481475	ENST00000535648	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000481475	ENST00000346706	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000481475	ENST00000340094	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000481475	ENST00000345230	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000481475	ENST00000350763	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000481475	ENST00000341037	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000481475	ENST00000423613	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-3UTR	ENST00000481475	ENST00000537320	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-intron	ENST00000481475	ENST00000542877	TNC	chr9	117783381	+	TNC	chr9	117783330	-
intron-intron	ENST00000481475	ENST00000481475	TNC	chr9	117783381	+	TNC	chr9	117783330	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for TNC-TNC

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TNC-TNC

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for TNC-TNC

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TNC-TNC

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TNC-TNC

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TNC-TNC

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	TNC	C3711374	Nonsyndromic Deafness	3	CLINGEN
Hgene	TNC	C0004096	Asthma	1	CTD_human
Hgene	TNC	C0014175	Endometriosis	1	CTD_human
Hgene	TNC	C0025202	melanoma	1	CTD_human
Hgene	TNC	C0029410	Osteoarthritis of hip	1	CTD_human
Hgene	TNC	C0032226	Pleural Diseases	1	CTD_human
Hgene	TNC	C0042345	Varicosity	1	CTD_human
Hgene	TNC	C0269102	Endometrioma	1	CTD_human
Hgene	TNC	C0273115	Lung Injury	1	CTD_human
Hgene	TNC	C2350344	Chronic Lung Injury	1	CTD_human
Hgene	TNC	C3810170	DEAFNESS, AUTOSOMAL DOMINANT 56	1	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	TNC	C3711374	Nonsyndromic Deafness	3	CLINGEN
Tgene	TNC	C0004096	Asthma	1	CTD_human
Tgene	TNC	C0014175	Endometriosis	1	CTD_human
Tgene	TNC	C0025202	melanoma	1	CTD_human
Tgene	TNC	C0029410	Osteoarthritis of hip	1	CTD_human
Tgene	TNC	C0032226	Pleural Diseases	1	CTD_human
Tgene	TNC	C0042345	Varicosity	1	CTD_human
Tgene	TNC	C0269102	Endometrioma	1	CTD_human
Tgene	TNC	C0273115	Lung Injury	1	CTD_human
Tgene	TNC	C2350344	Chronic Lung Injury	1	CTD_human
Tgene	TNC	C3810170	DEAFNESS, AUTOSOMAL DOMINANT 56	1	CTD_human;GENOMICS_ENGLAND;UNIPROT