Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TNC-TPM1 (FusionGDB2 ID:91946)

Fusion Gene Summary for TNC-TPM1

Fusion gene summary

Fusion gene information	Fusion gene name: TNC-TPM1
	Fusion gene ID: 91946
		Hgene	Tgene
	Gene symbol	TNC	TPM1
	Gene ID	7134	7168
	Gene name	troponin C1, slow skeletal and cardiac type	tropomyosin 1
	Synonyms	CMD1Z\|CMH13\|TN-C\|TNC\|TNNC	C15orf13\|CMD1Y\|CMH3\|HEL-S-265\|HTM-alpha\|LVNC9\|TMSA
	Cytomap	3p21.1	15q22.2
	Type of gene	protein-coding	protein-coding
	Description	troponin C, slow skeletal and cardiac musclescardiac troponin Cslow twitch skeletal/cardiac muscle troponin Ctroponin C type 1 (slow)	tropomyosin alpha-1 chaincardiomyopathy, hypertrophic 3epididymis secretory protein Li 265sarcomeric tropomyosin kappa
	Modification date	20200313	20200320
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000535648, ENST00000346706, ENST00000340094, ENST00000345230, ENST00000350763, ENST00000341037, ENST00000423613, ENST00000537320, ENST00000542877, ENST00000481475,	ENST00000288398, ENST00000358278, ENST00000560445, ENST00000403994, ENST00000357980, ENST00000559556, ENST00000559397, ENST00000267996, ENST00000334895, ENST00000404484, ENST00000560959, ENST00000559281, ENST00000317516,
Fusion gene scores	* DoF score	6 X 9 X 3=162	14 X 8 X 8=896
	# samples	8	16
	** MAII score	log2(8/162*10)=-1.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/896*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TNC [Title/Abstract] AND TPM1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TNC(117810513)-TPM1(63336262), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TNC	GO:0006937	regulation of muscle contraction	18092822
Hgene	TNC	GO:0060048	cardiac muscle contraction	25771144

Fusion gene breakpoints across TNC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TPM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	Z24727	TNC	chr9	117810513	+	TPM1	chr15	63336262	+

Top

Fusion Gene ORF analysis for TNC-TPM1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000535648	ENST00000288398	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000535648	ENST00000358278	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000535648	ENST00000560445	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000535648	ENST00000403994	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000535648	ENST00000357980	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000535648	ENST00000559556	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000535648	ENST00000559397	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000535648	ENST00000267996	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000535648	ENST00000334895	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000535648	ENST00000404484	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000535648	ENST00000560959	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000535648	ENST00000559281	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000535648	ENST00000317516	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000346706	ENST00000288398	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000346706	ENST00000358278	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000346706	ENST00000560445	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000346706	ENST00000403994	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000346706	ENST00000357980	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000346706	ENST00000559556	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000346706	ENST00000559397	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000346706	ENST00000267996	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000346706	ENST00000334895	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000346706	ENST00000404484	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000346706	ENST00000560959	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000346706	ENST00000559281	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000346706	ENST00000317516	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000340094	ENST00000288398	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000340094	ENST00000358278	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000340094	ENST00000560445	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000340094	ENST00000403994	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000340094	ENST00000357980	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000340094	ENST00000559556	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000340094	ENST00000559397	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000340094	ENST00000267996	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000340094	ENST00000334895	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000340094	ENST00000404484	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000340094	ENST00000560959	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000340094	ENST00000559281	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000340094	ENST00000317516	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000345230	ENST00000288398	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000345230	ENST00000358278	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000345230	ENST00000560445	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000345230	ENST00000403994	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000345230	ENST00000357980	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000345230	ENST00000559556	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000345230	ENST00000559397	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000345230	ENST00000267996	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000345230	ENST00000334895	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000345230	ENST00000404484	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000345230	ENST00000560959	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000345230	ENST00000559281	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000345230	ENST00000317516	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000350763	ENST00000288398	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000350763	ENST00000358278	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000350763	ENST00000560445	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000350763	ENST00000403994	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000350763	ENST00000357980	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000350763	ENST00000559556	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000350763	ENST00000559397	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000350763	ENST00000267996	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000350763	ENST00000334895	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000350763	ENST00000404484	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000350763	ENST00000560959	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000350763	ENST00000559281	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000350763	ENST00000317516	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000341037	ENST00000288398	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000341037	ENST00000358278	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000341037	ENST00000560445	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000341037	ENST00000403994	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000341037	ENST00000357980	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000341037	ENST00000559556	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000341037	ENST00000559397	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000341037	ENST00000267996	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000341037	ENST00000334895	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000341037	ENST00000404484	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000341037	ENST00000560959	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000341037	ENST00000559281	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000341037	ENST00000317516	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000423613	ENST00000288398	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000423613	ENST00000358278	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000423613	ENST00000560445	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000423613	ENST00000403994	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000423613	ENST00000357980	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000423613	ENST00000559556	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000423613	ENST00000559397	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000423613	ENST00000267996	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000423613	ENST00000334895	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000423613	ENST00000404484	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000423613	ENST00000560959	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000423613	ENST00000559281	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000423613	ENST00000317516	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000537320	ENST00000288398	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000537320	ENST00000358278	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000537320	ENST00000560445	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000537320	ENST00000403994	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000537320	ENST00000357980	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000537320	ENST00000559556	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000537320	ENST00000559397	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000537320	ENST00000267996	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000537320	ENST00000334895	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000537320	ENST00000404484	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000537320	ENST00000560959	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000537320	ENST00000559281	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000537320	ENST00000317516	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000542877	ENST00000288398	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000542877	ENST00000358278	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000542877	ENST00000560445	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000542877	ENST00000403994	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000542877	ENST00000357980	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000542877	ENST00000559556	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000542877	ENST00000559397	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000542877	ENST00000267996	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000542877	ENST00000334895	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000542877	ENST00000404484	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000542877	ENST00000560959	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000542877	ENST00000559281	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000542877	ENST00000317516	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000481475	ENST00000288398	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000481475	ENST00000358278	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000481475	ENST00000560445	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000481475	ENST00000403994	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000481475	ENST00000357980	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-3CDS	ENST00000481475	ENST00000559556	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000481475	ENST00000559397	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000481475	ENST00000267996	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000481475	ENST00000334895	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000481475	ENST00000404484	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000481475	ENST00000560959	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000481475	ENST00000559281	TNC	chr9	117810513	+	TPM1	chr15	63336262	+
intron-intron	ENST00000481475	ENST00000317516	TNC	chr9	117810513	+	TPM1	chr15	63336262	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for TNC-TPM1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for TNC-TPM1

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for TNC-TPM1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for TNC-TPM1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TNC-TPM1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TNC-TPM1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	TNC	C3711374	Nonsyndromic Deafness	3	CLINGEN
Hgene	TNC	C0004096	Asthma	1	CTD_human
Hgene	TNC	C0014175	Endometriosis	1	CTD_human
Hgene	TNC	C0025202	melanoma	1	CTD_human
Hgene	TNC	C0029410	Osteoarthritis of hip	1	CTD_human
Hgene	TNC	C0032226	Pleural Diseases	1	CTD_human
Hgene	TNC	C0042345	Varicosity	1	CTD_human
Hgene	TNC	C0269102	Endometrioma	1	CTD_human
Hgene	TNC	C0273115	Lung Injury	1	CTD_human
Hgene	TNC	C2350344	Chronic Lung Injury	1	CTD_human
Hgene	TNC	C3810170	DEAFNESS, AUTOSOMAL DOMINANT 56	1	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	TPM1	C0007194	Hypertrophic Cardiomyopathy	18	CLINGEN
Tgene	TPM1	C1861863	CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 3 (disorder)	9	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	TPM1	C2678476	Cardiomyopathy, Dilated, 1y	5	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	TPM1	C0014859	Esophageal Neoplasms	1	CTD_human
Tgene	TPM1	C0020538	Hypertensive disease	1	CTD_human
Tgene	TPM1	C0022548	Keloid	1	CTD_human
Tgene	TPM1	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene	TPM1	C0279626	Squamous cell carcinoma of esophagus	1	CTD_human
Tgene	TPM1	C0340427	Familial dilated cardiomyopathy	1	ORPHANET
Tgene	TPM1	C0546837	Malignant neoplasm of esophagus	1	CTD_human
Tgene	TPM1	C0597124	Obstructive asymmetric septal hypertrophy	1	CTD_human
Tgene	TPM1	C0700053	Idiopathic hypertrophic subaortic stenosis	1	CTD_human
Tgene	TPM1	C0949658	Cardiomyopathy, Hypertrophic, Familial	1	CTD_human
Tgene	TPM1	C1960469	Left ventricular noncompaction	1	ORPHANET