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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TNFRSF1A-CHD4 (FusionGDB2 ID:92010)

Fusion Gene Summary for TNFRSF1A-CHD4

check button Fusion gene summary
Fusion gene informationFusion gene name: TNFRSF1A-CHD4
Fusion gene ID: 92010
HgeneTgene
Gene symbol

TNFRSF1A

CHD4

Gene ID

7132

1108

Gene nameTNF receptor superfamily member 1Achromodomain helicase DNA binding protein 4
SynonymsCD120a|FPF|TBP1|TNF-R|TNF-R-I|TNF-R55|TNFAR|TNFR1|TNFR55|TNFR60|p55|p55-R|p60CHD-4|Mi-2b|Mi2-BETA|SIHIWES
Cytomap

12p13.31

12p13.31

Type of geneprotein-codingprotein-coding
Descriptiontumor necrosis factor receptor superfamily member 1ATNF-R1TNF-RITNFR-Itumor necrosis factor binding protein 1tumor necrosis factor receptor 1A isoform betatumor necrosis factor receptor type 1tumor necrosis factor-alpha receptorchromodomain-helicase-DNA-binding protein 4ATP-dependent helicase CHD4Mi-2 autoantigen 218 kDa protein
Modification date2020032220200313
UniProtAcc.

Q14839

Ensembl transtripts involved in fusion geneENST00000162749, ENST00000540022, 
ENST00000366159, ENST00000437813, 
ENST00000544484, ENST00000357008, 
ENST00000309577, ENST00000544040, 
ENST00000540960, 
Fusion gene scores* DoF score7 X 7 X 5=24513 X 16 X 7=1456
# samples 917
** MAII scorelog2(9/245*10)=-1.4447848426729
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1456*10)=-3.098403704061
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNFRSF1A [Title/Abstract] AND CHD4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTNFRSF1A(6450942)-CHD4(6682435), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TNFRSF1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CHD4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-D3-A2JN-06ATNFRSF1Achr12

6450942

-CHD4chr12

6682435

-
ChimerDB4SKCMTCGA-D3-A2JN-06ATNFRSF1Achr12

6450942

-CHD4chr12

6682435

-


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Fusion Gene ORF analysis for TNFRSF1A-CHD4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000162749ENST00000544484TNFRSF1Achr12

6450942

-CHD4chr12

6682435

-
In-frameENST00000162749ENST00000357008TNFRSF1Achr12

6450942

-CHD4chr12

6682435

-
In-frameENST00000162749ENST00000309577TNFRSF1Achr12

6450942

-CHD4chr12

6682435

-
In-frameENST00000162749ENST00000544040TNFRSF1Achr12

6450942

-CHD4chr12

6682435

-
5CDS-intronENST00000162749ENST00000540960TNFRSF1Achr12

6450942

-CHD4chr12

6682435

-
In-frameENST00000540022ENST00000544484TNFRSF1Achr12

6450942

-CHD4chr12

6682435

-
In-frameENST00000540022ENST00000357008TNFRSF1Achr12

6450942

-CHD4chr12

6682435

-
In-frameENST00000540022ENST00000309577TNFRSF1Achr12

6450942

-CHD4chr12

6682435

-
In-frameENST00000540022ENST00000544040TNFRSF1Achr12

6450942

-CHD4chr12

6682435

-
5CDS-intronENST00000540022ENST00000540960TNFRSF1Achr12

6450942

-CHD4chr12

6682435

-
In-frameENST00000366159ENST00000544484TNFRSF1Achr12

6450942

-CHD4chr12

6682435

-
In-frameENST00000366159ENST00000357008TNFRSF1Achr12

6450942

-CHD4chr12

6682435

-
In-frameENST00000366159ENST00000309577TNFRSF1Achr12

6450942

-CHD4chr12

6682435

-
In-frameENST00000366159ENST00000544040TNFRSF1Achr12

6450942

-CHD4chr12

6682435

-
5CDS-intronENST00000366159ENST00000540960TNFRSF1Achr12

6450942

-CHD4chr12

6682435

-
intron-3CDSENST00000437813ENST00000544484TNFRSF1Achr12

6450942

-CHD4chr12

6682435

-
intron-3CDSENST00000437813ENST00000357008TNFRSF1Achr12

6450942

-CHD4chr12

6682435

-
intron-3CDSENST00000437813ENST00000309577TNFRSF1Achr12

6450942

-CHD4chr12

6682435

-
intron-3CDSENST00000437813ENST00000544040TNFRSF1Achr12

6450942

-CHD4chr12

6682435

-
intron-intronENST00000437813ENST00000540960TNFRSF1Achr12

6450942

-CHD4chr12

6682435

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000162749TNFRSF1Achr126450942-ENST00000544484CHD4chr126682435-1310339291716141
ENST00000162749TNFRSF1Achr126450942-ENST00000357008CHD4chr126682435-1310339291716141
ENST00000162749TNFRSF1Achr126450942-ENST00000309577CHD4chr126682435-1310339291716141
ENST00000162749TNFRSF1Achr126450942-ENST00000544040CHD4chr126682435-1310339291716141
ENST00000540022TNFRSF1Achr126450942-ENST00000544484CHD4chr126682435-1223252204629141
ENST00000540022TNFRSF1Achr126450942-ENST00000357008CHD4chr126682435-1223252204629141
ENST00000540022TNFRSF1Achr126450942-ENST00000309577CHD4chr126682435-1223252204629141
ENST00000540022TNFRSF1Achr126450942-ENST00000544040CHD4chr126682435-1223252204629141
ENST00000366159TNFRSF1Achr126450942-ENST00000544484CHD4chr126682435-10447325450141
ENST00000366159TNFRSF1Achr126450942-ENST00000357008CHD4chr126682435-10447325450141
ENST00000366159TNFRSF1Achr126450942-ENST00000309577CHD4chr126682435-10447325450141
ENST00000366159TNFRSF1Achr126450942-ENST00000544040CHD4chr126682435-10447325450141

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000162749ENST00000544484TNFRSF1Achr126450942-CHD4chr126682435-0.0158058520.9841942
ENST00000162749ENST00000357008TNFRSF1Achr126450942-CHD4chr126682435-0.0158058520.9841942
ENST00000162749ENST00000309577TNFRSF1Achr126450942-CHD4chr126682435-0.0158058520.9841942
ENST00000162749ENST00000544040TNFRSF1Achr126450942-CHD4chr126682435-0.0158058520.9841942
ENST00000540022ENST00000544484TNFRSF1Achr126450942-CHD4chr126682435-0.0122975890.9877024
ENST00000540022ENST00000357008TNFRSF1Achr126450942-CHD4chr126682435-0.0122975890.9877024
ENST00000540022ENST00000309577TNFRSF1Achr126450942-CHD4chr126682435-0.0122975890.9877024
ENST00000540022ENST00000544040TNFRSF1Achr126450942-CHD4chr126682435-0.0122975890.9877024
ENST00000366159ENST00000544484TNFRSF1Achr126450942-CHD4chr126682435-0.0095513850.99044865
ENST00000366159ENST00000357008TNFRSF1Achr126450942-CHD4chr126682435-0.0095513850.99044865
ENST00000366159ENST00000309577TNFRSF1Achr126450942-CHD4chr126682435-0.0095513850.99044865
ENST00000366159ENST00000544040TNFRSF1Achr126450942-CHD4chr126682435-0.0095513850.99044865

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Fusion Genomic Features for TNFRSF1A-CHD4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TNFRSF1A-CHD4


check button Go to

FGviewer for the breakpoints of chr12:6450942-chr12:6682435

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CHD4

Q14839

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. {ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:9804427}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNFRSF1Achr12:6450942chr12:6682435ENST00000162749-110356_44113.0456.0DomainDeath
HgeneTNFRSF1Achr12:6450942chr12:6682435ENST00000366159-16356_44113.0219.0DomainDeath
HgeneTNFRSF1Achr12:6450942chr12:6682435ENST00000162749-110338_34813.0456.0RegionNote=N-SMase activation domain (NSD)
HgeneTNFRSF1Achr12:6450942chr12:6682435ENST00000366159-16338_34813.0219.0RegionNote=N-SMase activation domain (NSD)
HgeneTNFRSF1Achr12:6450942chr12:6682435ENST00000162749-110126_16613.0456.0RepeatNote=TNFR-Cys 3
HgeneTNFRSF1Achr12:6450942chr12:6682435ENST00000162749-110167_19613.0456.0RepeatNote=TNFR-Cys 4
HgeneTNFRSF1Achr12:6450942chr12:6682435ENST00000162749-11043_8213.0456.0RepeatNote=TNFR-Cys 1
HgeneTNFRSF1Achr12:6450942chr12:6682435ENST00000162749-11083_12513.0456.0RepeatNote=TNFR-Cys 2
HgeneTNFRSF1Achr12:6450942chr12:6682435ENST00000366159-16126_16613.0219.0RepeatNote=TNFR-Cys 3
HgeneTNFRSF1Achr12:6450942chr12:6682435ENST00000366159-16167_19613.0219.0RepeatNote=TNFR-Cys 4
HgeneTNFRSF1Achr12:6450942chr12:6682435ENST00000366159-1643_8213.0219.0RepeatNote=TNFR-Cys 1
HgeneTNFRSF1Achr12:6450942chr12:6682435ENST00000366159-1683_12513.0219.0RepeatNote=TNFR-Cys 2
HgeneTNFRSF1Achr12:6450942chr12:6682435ENST00000162749-110233_45513.0456.0Topological domainCytoplasmic
HgeneTNFRSF1Achr12:6450942chr12:6682435ENST00000162749-11030_21113.0456.0Topological domainExtracellular
HgeneTNFRSF1Achr12:6450942chr12:6682435ENST00000366159-16233_45513.0219.0Topological domainCytoplasmic
HgeneTNFRSF1Achr12:6450942chr12:6682435ENST00000366159-1630_21113.0219.0Topological domainExtracellular
HgeneTNFRSF1Achr12:6450942chr12:6682435ENST00000162749-110212_23213.0456.0TransmembraneHelical
HgeneTNFRSF1Achr12:6450942chr12:6682435ENST00000366159-16212_23213.0219.0TransmembraneHelical
TgeneCHD4chr12:6450942chr12:6682435ENST0000030957735391052_10551815.01941.0Compositional biasNote=Poly-Leu
TgeneCHD4chr12:6450942chr12:6682435ENST000003095773539114_1191815.01941.0Compositional biasNote=Poly-Lys
TgeneCHD4chr12:6450942chr12:6682435ENST0000030957735391294_13011815.01941.0Compositional biasNote=Poly-Glu
TgeneCHD4chr12:6450942chr12:6682435ENST000003095773539134_1381815.01941.0Compositional biasNote=Poly-Glu
TgeneCHD4chr12:6450942chr12:6682435ENST000003095773539139_1441815.01941.0Compositional biasNote=Poly-Asp
TgeneCHD4chr12:6450942chr12:6682435ENST0000030957735391665_16681815.01941.0Compositional biasNote=Poly-Glu
TgeneCHD4chr12:6450942chr12:6682435ENST000003095773539227_2351815.01941.0Compositional biasNote=Poly-Ala
TgeneCHD4chr12:6450942chr12:6682435ENST000003095773539248_2521815.01941.0Compositional biasNote=Poly-Pro
TgeneCHD4chr12:6450942chr12:6682435ENST000003095773539350_3541815.01941.0Compositional biasNote=Poly-Lys
TgeneCHD4chr12:6450942chr12:6682435ENST00000309577353950_591815.01941.0Compositional biasNote=Poly-Lys
TgeneCHD4chr12:6450942chr12:6682435ENST00000309577353994_981815.01941.0Compositional biasNote=Poly-Glu
TgeneCHD4chr12:6450942chr12:6682435ENST0000035700836401052_10551787.01913.0Compositional biasNote=Poly-Leu
TgeneCHD4chr12:6450942chr12:6682435ENST000003570083640114_1191787.01913.0Compositional biasNote=Poly-Lys
TgeneCHD4chr12:6450942chr12:6682435ENST0000035700836401294_13011787.01913.0Compositional biasNote=Poly-Glu
TgeneCHD4chr12:6450942chr12:6682435ENST000003570083640134_1381787.01913.0Compositional biasNote=Poly-Glu
TgeneCHD4chr12:6450942chr12:6682435ENST000003570083640139_1441787.01913.0Compositional biasNote=Poly-Asp
TgeneCHD4chr12:6450942chr12:6682435ENST0000035700836401665_16681787.01913.0Compositional biasNote=Poly-Glu
TgeneCHD4chr12:6450942chr12:6682435ENST000003570083640227_2351787.01913.0Compositional biasNote=Poly-Ala
TgeneCHD4chr12:6450942chr12:6682435ENST000003570083640248_2521787.01913.0Compositional biasNote=Poly-Pro
TgeneCHD4chr12:6450942chr12:6682435ENST000003570083640350_3541787.01913.0Compositional biasNote=Poly-Lys
TgeneCHD4chr12:6450942chr12:6682435ENST00000357008364050_591787.01913.0Compositional biasNote=Poly-Lys
TgeneCHD4chr12:6450942chr12:6682435ENST00000357008364094_981787.01913.0Compositional biasNote=Poly-Glu
TgeneCHD4chr12:6450942chr12:6682435ENST0000054448435391052_10551812.01938.0Compositional biasNote=Poly-Leu
TgeneCHD4chr12:6450942chr12:6682435ENST000005444843539114_1191812.01938.0Compositional biasNote=Poly-Lys
TgeneCHD4chr12:6450942chr12:6682435ENST0000054448435391294_13011812.01938.0Compositional biasNote=Poly-Glu
TgeneCHD4chr12:6450942chr12:6682435ENST000005444843539134_1381812.01938.0Compositional biasNote=Poly-Glu
TgeneCHD4chr12:6450942chr12:6682435ENST000005444843539139_1441812.01938.0Compositional biasNote=Poly-Asp
TgeneCHD4chr12:6450942chr12:6682435ENST0000054448435391665_16681812.01938.0Compositional biasNote=Poly-Glu
TgeneCHD4chr12:6450942chr12:6682435ENST000005444843539227_2351812.01938.0Compositional biasNote=Poly-Ala
TgeneCHD4chr12:6450942chr12:6682435ENST000005444843539248_2521812.01938.0Compositional biasNote=Poly-Pro
TgeneCHD4chr12:6450942chr12:6682435ENST000005444843539350_3541812.01938.0Compositional biasNote=Poly-Lys
TgeneCHD4chr12:6450942chr12:6682435ENST00000544484353950_591812.01938.0Compositional biasNote=Poly-Lys
TgeneCHD4chr12:6450942chr12:6682435ENST00000544484353994_981812.01938.0Compositional biasNote=Poly-Glu
TgeneCHD4chr12:6450942chr12:6682435ENST0000030957735391054_12031815.01941.0DomainHelicase C-terminal
TgeneCHD4chr12:6450942chr12:6682435ENST000003095773539494_5941815.01941.0DomainChromo 1
TgeneCHD4chr12:6450942chr12:6682435ENST000003095773539622_6971815.01941.0DomainChromo 2
TgeneCHD4chr12:6450942chr12:6682435ENST000003095773539738_9221815.01941.0DomainHelicase ATP-binding
TgeneCHD4chr12:6450942chr12:6682435ENST0000035700836401054_12031787.01913.0DomainHelicase C-terminal
TgeneCHD4chr12:6450942chr12:6682435ENST000003570083640494_5941787.01913.0DomainChromo 1
TgeneCHD4chr12:6450942chr12:6682435ENST000003570083640622_6971787.01913.0DomainChromo 2
TgeneCHD4chr12:6450942chr12:6682435ENST000003570083640738_9221787.01913.0DomainHelicase ATP-binding
TgeneCHD4chr12:6450942chr12:6682435ENST0000054448435391054_12031812.01938.0DomainHelicase C-terminal
TgeneCHD4chr12:6450942chr12:6682435ENST000005444843539494_5941812.01938.0DomainChromo 1
TgeneCHD4chr12:6450942chr12:6682435ENST000005444843539622_6971812.01938.0DomainChromo 2
TgeneCHD4chr12:6450942chr12:6682435ENST000005444843539738_9221812.01938.0DomainHelicase ATP-binding
TgeneCHD4chr12:6450942chr12:6682435ENST000003095773539873_8761815.01941.0MotifNote=DEAH box
TgeneCHD4chr12:6450942chr12:6682435ENST000003570083640873_8761787.01913.0MotifNote=DEAH box
TgeneCHD4chr12:6450942chr12:6682435ENST000005444843539873_8761812.01938.0MotifNote=DEAH box
TgeneCHD4chr12:6450942chr12:6682435ENST000003095773539751_7581815.01941.0Nucleotide bindingATP
TgeneCHD4chr12:6450942chr12:6682435ENST000003570083640751_7581787.01913.0Nucleotide bindingATP
TgeneCHD4chr12:6450942chr12:6682435ENST000005444843539751_7581812.01938.0Nucleotide bindingATP
TgeneCHD4chr12:6450942chr12:6682435ENST000003095773539370_4171815.01941.0Zinc fingerPHD-type 1
TgeneCHD4chr12:6450942chr12:6682435ENST000003095773539449_4961815.01941.0Zinc fingerPHD-type 2
TgeneCHD4chr12:6450942chr12:6682435ENST000003570083640370_4171787.01913.0Zinc fingerPHD-type 1
TgeneCHD4chr12:6450942chr12:6682435ENST000003570083640449_4961787.01913.0Zinc fingerPHD-type 2
TgeneCHD4chr12:6450942chr12:6682435ENST000005444843539370_4171812.01938.0Zinc fingerPHD-type 1
TgeneCHD4chr12:6450942chr12:6682435ENST000005444843539449_4961812.01938.0Zinc fingerPHD-type 2


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Fusion Gene Sequence for TNFRSF1A-CHD4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000162749_ENST00000544484_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(transcript)=1310nt_BP=339nt
CTCCAGCTCTTCCTGTCCCGCTGTTGCAACACTGCCTCACTCTTCCCCTCCCACCTTCTCTCCCCTCCTCTCTGCTTTAATTTTCTCAGA
ATTCTCTGGACTGAGGCTCCAGTTCTGGCCTTTGGGGTTCAAGATCACTGGGACCAGGCCGTGATCTCTATGCCCGAGTCTCAACCCTCA
ACTGTCACCCCAAGGCACTTGGGACGTCCTGGACAGACCGAGTCCCGGGAAGCCCCAGCACTGCCGCTGCCACACTGCCCTGAGCCCAAA
TGGGGGAGTGAGAGGCCATAGCTGTCTGGCATGGGCCTCTCCACCGTGCCTGACCTGCTGCTGCCACTGCTCTTAGAACAAGCTCTGGTG
ATTGAGGAACAGCTGCGCCGGGCTGCTTACTTGAACATGTCAGAAGACCCTTCTCACCCTTCCATGGCCCTCAACACCCGCTTTGCTGAG
GTGGAGTGTTTGGCGGAAAGTCATCAGCACCTGTCCAAGGAGTCAATGGCAGGAAACAAGCCAGCCAATGCAGTCCTGCACAAAGTTCTG
AAACAGCTGGAAGAACTGCTGAGTGACATGAAAGCTGATGTGACTCGACTCCCAGCTACCATTGCCCGAATTCCCCCAGTTGCTGTGAGG
TTACAGATGTCAGAGCGTAACATTCTCAGCCGCCTGGCAAACCGGGCACCCGAACCTACCCCACAGCAGGTAGCCCAGCAGCAGTGAAGA
TGCAGACTGATACCACCTCCACCGCTGAGCAGTGACCTTCCTCACTTTCTCTTGTCCCAGCTTCTCCCCTGGGGGCCTGAGAGACCCTCA
CCTTCCTTCTGCCCATCTTCCATGTTGTAAAGGAACAGCCCCAGTGCACTGGGGGAGGGGAGGGAGTGAGGGGCAGTGGTGCCCTTCCTG
CAGAAGAGACATGCAGCAGTAGCGCTGGCGCCATCTGCAGGAGCTGGCGGGCTGGCCTTCTGGACCCTGGCTTCTCCCCACTGTAACGCC
TGTTACACACAAACTGTTGTGGGTTCCTGCCAGGCTTGAAGAAAATGATCTGAATTTTTTCCTCCTTTTGGTTTTATTTTGTTGGTTTAT
TTTGTGTTTTCTTTTCTCCTTTTTGGGGGGTATTCAGAGTGGGCTGGGCCCCTGGGCGAGACACAGCTACCTCTGTTGGCATCTTTTTAA
TACCAGGAACCCAGCGGCTCTAGCCACTGAGCGGCTAAATGAAATAAAGTGGAAAAAAAAAAAAAGGAAAAAACCAAAAGCATAAAAAAC

>In-frame_ENST00000162749_ENST00000544484_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(amino acids)=141AA_start in transcript=291_stop in transcript=716
MSGMGLSTVPDLLLPLLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELL

--------------------------------------------------------------
>In-frame_ENST00000162749_ENST00000357008_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(transcript)=1310nt_BP=339nt
CTCCAGCTCTTCCTGTCCCGCTGTTGCAACACTGCCTCACTCTTCCCCTCCCACCTTCTCTCCCCTCCTCTCTGCTTTAATTTTCTCAGA
ATTCTCTGGACTGAGGCTCCAGTTCTGGCCTTTGGGGTTCAAGATCACTGGGACCAGGCCGTGATCTCTATGCCCGAGTCTCAACCCTCA
ACTGTCACCCCAAGGCACTTGGGACGTCCTGGACAGACCGAGTCCCGGGAAGCCCCAGCACTGCCGCTGCCACACTGCCCTGAGCCCAAA
TGGGGGAGTGAGAGGCCATAGCTGTCTGGCATGGGCCTCTCCACCGTGCCTGACCTGCTGCTGCCACTGCTCTTAGAACAAGCTCTGGTG
ATTGAGGAACAGCTGCGCCGGGCTGCTTACTTGAACATGTCAGAAGACCCTTCTCACCCTTCCATGGCCCTCAACACCCGCTTTGCTGAG
GTGGAGTGTTTGGCGGAAAGTCATCAGCACCTGTCCAAGGAGTCAATGGCAGGAAACAAGCCAGCCAATGCAGTCCTGCACAAAGTTCTG
AAACAGCTGGAAGAACTGCTGAGTGACATGAAAGCTGATGTGACTCGACTCCCAGCTACCATTGCCCGAATTCCCCCAGTTGCTGTGAGG
TTACAGATGTCAGAGCGTAACATTCTCAGCCGCCTGGCAAACCGGGCACCCGAACCTACCCCACAGCAGGTAGCCCAGCAGCAGTGAAGA
TGCAGACTGATACCACCTCCACCGCTGAGCAGTGACCTTCCTCACTTTCTCTTGTCCCAGCTTCTCCCCTGGGGGCCTGAGAGACCCTCA
CCTTCCTTCTGCCCATCTTCCATGTTGTAAAGGAACAGCCCCAGTGCACTGGGGGAGGGGAGGGAGTGAGGGGCAGTGGTGCCCTTCCTG
CAGAAGAGACATGCAGCAGTAGCGCTGGCGCCATCTGCAGGAGCTGGCGGGCTGGCCTTCTGGACCCTGGCTTCTCCCCACTGTAACGCC
TGTTACACACAAACTGTTGTGGGTTCCTGCCAGGCTTGAAGAAAATGATCTGAATTTTTTCCTCCTTTTGGTTTTATTTTGTTGGTTTAT
TTTGTGTTTTCTTTTCTCCTTTTTGGGGGGTATTCAGAGTGGGCTGGGCCCCTGGGCGAGACACAGCTACCTCTGTTGGCATCTTTTTAA
TACCAGGAACCCAGCGGCTCTAGCCACTGAGCGGCTAAATGAAATAAAGTGGAAAAAAAAAAAAAGGAAAAAACCAAAAGCATAAAAAAC

>In-frame_ENST00000162749_ENST00000357008_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(amino acids)=141AA_start in transcript=291_stop in transcript=716
MSGMGLSTVPDLLLPLLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELL

--------------------------------------------------------------
>In-frame_ENST00000162749_ENST00000309577_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(transcript)=1310nt_BP=339nt
CTCCAGCTCTTCCTGTCCCGCTGTTGCAACACTGCCTCACTCTTCCCCTCCCACCTTCTCTCCCCTCCTCTCTGCTTTAATTTTCTCAGA
ATTCTCTGGACTGAGGCTCCAGTTCTGGCCTTTGGGGTTCAAGATCACTGGGACCAGGCCGTGATCTCTATGCCCGAGTCTCAACCCTCA
ACTGTCACCCCAAGGCACTTGGGACGTCCTGGACAGACCGAGTCCCGGGAAGCCCCAGCACTGCCGCTGCCACACTGCCCTGAGCCCAAA
TGGGGGAGTGAGAGGCCATAGCTGTCTGGCATGGGCCTCTCCACCGTGCCTGACCTGCTGCTGCCACTGCTCTTAGAACAAGCTCTGGTG
ATTGAGGAACAGCTGCGCCGGGCTGCTTACTTGAACATGTCAGAAGACCCTTCTCACCCTTCCATGGCCCTCAACACCCGCTTTGCTGAG
GTGGAGTGTTTGGCGGAAAGTCATCAGCACCTGTCCAAGGAGTCAATGGCAGGAAACAAGCCAGCCAATGCAGTCCTGCACAAAGTTCTG
AAACAGCTGGAAGAACTGCTGAGTGACATGAAAGCTGATGTGACTCGACTCCCAGCTACCATTGCCCGAATTCCCCCAGTTGCTGTGAGG
TTACAGATGTCAGAGCGTAACATTCTCAGCCGCCTGGCAAACCGGGCACCCGAACCTACCCCACAGCAGGTAGCCCAGCAGCAGTGAAGA
TGCAGACTGATACCACCTCCACCGCTGAGCAGTGACCTTCCTCACTTTCTCTTGTCCCAGCTTCTCCCCTGGGGGCCTGAGAGACCCTCA
CCTTCCTTCTGCCCATCTTCCATGTTGTAAAGGAACAGCCCCAGTGCACTGGGGGAGGGGAGGGAGTGAGGGGCAGTGGTGCCCTTCCTG
CAGAAGAGACATGCAGCAGTAGCGCTGGCGCCATCTGCAGGAGCTGGCGGGCTGGCCTTCTGGACCCTGGCTTCTCCCCACTGTAACGCC
TGTTACACACAAACTGTTGTGGGTTCCTGCCAGGCTTGAAGAAAATGATCTGAATTTTTTCCTCCTTTTGGTTTTATTTTGTTGGTTTAT
TTTGTGTTTTCTTTTCTCCTTTTTGGGGGGTATTCAGAGTGGGCTGGGCCCCTGGGCGAGACACAGCTACCTCTGTTGGCATCTTTTTAA
TACCAGGAACCCAGCGGCTCTAGCCACTGAGCGGCTAAATGAAATAAAGTGGAAAAAAAAAAAAAGGAAAAAACCAAAAGCATAAAAAAC

>In-frame_ENST00000162749_ENST00000309577_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(amino acids)=141AA_start in transcript=291_stop in transcript=716
MSGMGLSTVPDLLLPLLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELL

--------------------------------------------------------------
>In-frame_ENST00000162749_ENST00000544040_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(transcript)=1310nt_BP=339nt
CTCCAGCTCTTCCTGTCCCGCTGTTGCAACACTGCCTCACTCTTCCCCTCCCACCTTCTCTCCCCTCCTCTCTGCTTTAATTTTCTCAGA
ATTCTCTGGACTGAGGCTCCAGTTCTGGCCTTTGGGGTTCAAGATCACTGGGACCAGGCCGTGATCTCTATGCCCGAGTCTCAACCCTCA
ACTGTCACCCCAAGGCACTTGGGACGTCCTGGACAGACCGAGTCCCGGGAAGCCCCAGCACTGCCGCTGCCACACTGCCCTGAGCCCAAA
TGGGGGAGTGAGAGGCCATAGCTGTCTGGCATGGGCCTCTCCACCGTGCCTGACCTGCTGCTGCCACTGCTCTTAGAACAAGCTCTGGTG
ATTGAGGAACAGCTGCGCCGGGCTGCTTACTTGAACATGTCAGAAGACCCTTCTCACCCTTCCATGGCCCTCAACACCCGCTTTGCTGAG
GTGGAGTGTTTGGCGGAAAGTCATCAGCACCTGTCCAAGGAGTCAATGGCAGGAAACAAGCCAGCCAATGCAGTCCTGCACAAAGTTCTG
AAACAGCTGGAAGAACTGCTGAGTGACATGAAAGCTGATGTGACTCGACTCCCAGCTACCATTGCCCGAATTCCCCCAGTTGCTGTGAGG
TTACAGATGTCAGAGCGTAACATTCTCAGCCGCCTGGCAAACCGGGCACCCGAACCTACCCCACAGCAGGTAGCCCAGCAGCAGTGAAGA
TGCAGACTGATACCACCTCCACCGCTGAGCAGTGACCTTCCTCACTTTCTCTTGTCCCAGCTTCTCCCCTGGGGGCCTGAGAGACCCTCA
CCTTCCTTCTGCCCATCTTCCATGTTGTAAAGGAACAGCCCCAGTGCACTGGGGGAGGGGAGGGAGTGAGGGGCAGTGGTGCCCTTCCTG
CAGAAGAGACATGCAGCAGTAGCGCTGGCGCCATCTGCAGGAGCTGGCGGGCTGGCCTTCTGGACCCTGGCTTCTCCCCACTGTAACGCC
TGTTACACACAAACTGTTGTGGGTTCCTGCCAGGCTTGAAGAAAATGATCTGAATTTTTTCCTCCTTTTGGTTTTATTTTGTTGGTTTAT
TTTGTGTTTTCTTTTCTCCTTTTTGGGGGGTATTCAGAGTGGGCTGGGCCCCTGGGCGAGACACAGCTACCTCTGTTGGCATCTTTTTAA
TACCAGGAACCCAGCGGCTCTAGCCACTGAGCGGCTAAATGAAATAAAGTGGAAAAAAAAAAAAAGGAAAAAACCAAAAGCATAAAAAAC

>In-frame_ENST00000162749_ENST00000544040_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(amino acids)=141AA_start in transcript=291_stop in transcript=716
MSGMGLSTVPDLLLPLLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELL

--------------------------------------------------------------
>In-frame_ENST00000540022_ENST00000544484_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(transcript)=1223nt_BP=252nt
AGAATTCTCTGGACTGAGGCTCCAGTTCTGGCCTTTGGGGTTCAAGATCACTGGGACCAGGCCGTGATCTCTATGCCCGAGTCTCAACCC
TCAACTGTCACCCCAAGGCACTTGGGACGTCCTGGACAGACCGAGTCCCGGGAAGCCCCAGCACTGCCGCTGCCACACTGCCCTGAGCCC
AAATGGGGGAGTGAGAGGCCATAGCTGTCTGGCATGGGCCTCTCCACCGTGCCTGACCTGCTGCTGCCACTGCTCTTAGAACAAGCTCTG
GTGATTGAGGAACAGCTGCGCCGGGCTGCTTACTTGAACATGTCAGAAGACCCTTCTCACCCTTCCATGGCCCTCAACACCCGCTTTGCT
GAGGTGGAGTGTTTGGCGGAAAGTCATCAGCACCTGTCCAAGGAGTCAATGGCAGGAAACAAGCCAGCCAATGCAGTCCTGCACAAAGTT
CTGAAACAGCTGGAAGAACTGCTGAGTGACATGAAAGCTGATGTGACTCGACTCCCAGCTACCATTGCCCGAATTCCCCCAGTTGCTGTG
AGGTTACAGATGTCAGAGCGTAACATTCTCAGCCGCCTGGCAAACCGGGCACCCGAACCTACCCCACAGCAGGTAGCCCAGCAGCAGTGA
AGATGCAGACTGATACCACCTCCACCGCTGAGCAGTGACCTTCCTCACTTTCTCTTGTCCCAGCTTCTCCCCTGGGGGCCTGAGAGACCC
TCACCTTCCTTCTGCCCATCTTCCATGTTGTAAAGGAACAGCCCCAGTGCACTGGGGGAGGGGAGGGAGTGAGGGGCAGTGGTGCCCTTC
CTGCAGAAGAGACATGCAGCAGTAGCGCTGGCGCCATCTGCAGGAGCTGGCGGGCTGGCCTTCTGGACCCTGGCTTCTCCCCACTGTAAC
GCCTGTTACACACAAACTGTTGTGGGTTCCTGCCAGGCTTGAAGAAAATGATCTGAATTTTTTCCTCCTTTTGGTTTTATTTTGTTGGTT
TATTTTGTGTTTTCTTTTCTCCTTTTTGGGGGGTATTCAGAGTGGGCTGGGCCCCTGGGCGAGACACAGCTACCTCTGTTGGCATCTTTT
TAATACCAGGAACCCAGCGGCTCTAGCCACTGAGCGGCTAAATGAAATAAAGTGGAAAAAAAAAAAAAGGAAAAAACCAAAAGCATAAAA

>In-frame_ENST00000540022_ENST00000544484_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(amino acids)=141AA_start in transcript=204_stop in transcript=629
MSGMGLSTVPDLLLPLLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELL

--------------------------------------------------------------
>In-frame_ENST00000540022_ENST00000357008_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(transcript)=1223nt_BP=252nt
AGAATTCTCTGGACTGAGGCTCCAGTTCTGGCCTTTGGGGTTCAAGATCACTGGGACCAGGCCGTGATCTCTATGCCCGAGTCTCAACCC
TCAACTGTCACCCCAAGGCACTTGGGACGTCCTGGACAGACCGAGTCCCGGGAAGCCCCAGCACTGCCGCTGCCACACTGCCCTGAGCCC
AAATGGGGGAGTGAGAGGCCATAGCTGTCTGGCATGGGCCTCTCCACCGTGCCTGACCTGCTGCTGCCACTGCTCTTAGAACAAGCTCTG
GTGATTGAGGAACAGCTGCGCCGGGCTGCTTACTTGAACATGTCAGAAGACCCTTCTCACCCTTCCATGGCCCTCAACACCCGCTTTGCT
GAGGTGGAGTGTTTGGCGGAAAGTCATCAGCACCTGTCCAAGGAGTCAATGGCAGGAAACAAGCCAGCCAATGCAGTCCTGCACAAAGTT
CTGAAACAGCTGGAAGAACTGCTGAGTGACATGAAAGCTGATGTGACTCGACTCCCAGCTACCATTGCCCGAATTCCCCCAGTTGCTGTG
AGGTTACAGATGTCAGAGCGTAACATTCTCAGCCGCCTGGCAAACCGGGCACCCGAACCTACCCCACAGCAGGTAGCCCAGCAGCAGTGA
AGATGCAGACTGATACCACCTCCACCGCTGAGCAGTGACCTTCCTCACTTTCTCTTGTCCCAGCTTCTCCCCTGGGGGCCTGAGAGACCC
TCACCTTCCTTCTGCCCATCTTCCATGTTGTAAAGGAACAGCCCCAGTGCACTGGGGGAGGGGAGGGAGTGAGGGGCAGTGGTGCCCTTC
CTGCAGAAGAGACATGCAGCAGTAGCGCTGGCGCCATCTGCAGGAGCTGGCGGGCTGGCCTTCTGGACCCTGGCTTCTCCCCACTGTAAC
GCCTGTTACACACAAACTGTTGTGGGTTCCTGCCAGGCTTGAAGAAAATGATCTGAATTTTTTCCTCCTTTTGGTTTTATTTTGTTGGTT
TATTTTGTGTTTTCTTTTCTCCTTTTTGGGGGGTATTCAGAGTGGGCTGGGCCCCTGGGCGAGACACAGCTACCTCTGTTGGCATCTTTT
TAATACCAGGAACCCAGCGGCTCTAGCCACTGAGCGGCTAAATGAAATAAAGTGGAAAAAAAAAAAAAGGAAAAAACCAAAAGCATAAAA

>In-frame_ENST00000540022_ENST00000357008_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(amino acids)=141AA_start in transcript=204_stop in transcript=629
MSGMGLSTVPDLLLPLLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELL

--------------------------------------------------------------
>In-frame_ENST00000540022_ENST00000309577_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(transcript)=1223nt_BP=252nt
AGAATTCTCTGGACTGAGGCTCCAGTTCTGGCCTTTGGGGTTCAAGATCACTGGGACCAGGCCGTGATCTCTATGCCCGAGTCTCAACCC
TCAACTGTCACCCCAAGGCACTTGGGACGTCCTGGACAGACCGAGTCCCGGGAAGCCCCAGCACTGCCGCTGCCACACTGCCCTGAGCCC
AAATGGGGGAGTGAGAGGCCATAGCTGTCTGGCATGGGCCTCTCCACCGTGCCTGACCTGCTGCTGCCACTGCTCTTAGAACAAGCTCTG
GTGATTGAGGAACAGCTGCGCCGGGCTGCTTACTTGAACATGTCAGAAGACCCTTCTCACCCTTCCATGGCCCTCAACACCCGCTTTGCT
GAGGTGGAGTGTTTGGCGGAAAGTCATCAGCACCTGTCCAAGGAGTCAATGGCAGGAAACAAGCCAGCCAATGCAGTCCTGCACAAAGTT
CTGAAACAGCTGGAAGAACTGCTGAGTGACATGAAAGCTGATGTGACTCGACTCCCAGCTACCATTGCCCGAATTCCCCCAGTTGCTGTG
AGGTTACAGATGTCAGAGCGTAACATTCTCAGCCGCCTGGCAAACCGGGCACCCGAACCTACCCCACAGCAGGTAGCCCAGCAGCAGTGA
AGATGCAGACTGATACCACCTCCACCGCTGAGCAGTGACCTTCCTCACTTTCTCTTGTCCCAGCTTCTCCCCTGGGGGCCTGAGAGACCC
TCACCTTCCTTCTGCCCATCTTCCATGTTGTAAAGGAACAGCCCCAGTGCACTGGGGGAGGGGAGGGAGTGAGGGGCAGTGGTGCCCTTC
CTGCAGAAGAGACATGCAGCAGTAGCGCTGGCGCCATCTGCAGGAGCTGGCGGGCTGGCCTTCTGGACCCTGGCTTCTCCCCACTGTAAC
GCCTGTTACACACAAACTGTTGTGGGTTCCTGCCAGGCTTGAAGAAAATGATCTGAATTTTTTCCTCCTTTTGGTTTTATTTTGTTGGTT
TATTTTGTGTTTTCTTTTCTCCTTTTTGGGGGGTATTCAGAGTGGGCTGGGCCCCTGGGCGAGACACAGCTACCTCTGTTGGCATCTTTT
TAATACCAGGAACCCAGCGGCTCTAGCCACTGAGCGGCTAAATGAAATAAAGTGGAAAAAAAAAAAAAGGAAAAAACCAAAAGCATAAAA

>In-frame_ENST00000540022_ENST00000309577_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(amino acids)=141AA_start in transcript=204_stop in transcript=629
MSGMGLSTVPDLLLPLLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELL

--------------------------------------------------------------
>In-frame_ENST00000540022_ENST00000544040_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(transcript)=1223nt_BP=252nt
AGAATTCTCTGGACTGAGGCTCCAGTTCTGGCCTTTGGGGTTCAAGATCACTGGGACCAGGCCGTGATCTCTATGCCCGAGTCTCAACCC
TCAACTGTCACCCCAAGGCACTTGGGACGTCCTGGACAGACCGAGTCCCGGGAAGCCCCAGCACTGCCGCTGCCACACTGCCCTGAGCCC
AAATGGGGGAGTGAGAGGCCATAGCTGTCTGGCATGGGCCTCTCCACCGTGCCTGACCTGCTGCTGCCACTGCTCTTAGAACAAGCTCTG
GTGATTGAGGAACAGCTGCGCCGGGCTGCTTACTTGAACATGTCAGAAGACCCTTCTCACCCTTCCATGGCCCTCAACACCCGCTTTGCT
GAGGTGGAGTGTTTGGCGGAAAGTCATCAGCACCTGTCCAAGGAGTCAATGGCAGGAAACAAGCCAGCCAATGCAGTCCTGCACAAAGTT
CTGAAACAGCTGGAAGAACTGCTGAGTGACATGAAAGCTGATGTGACTCGACTCCCAGCTACCATTGCCCGAATTCCCCCAGTTGCTGTG
AGGTTACAGATGTCAGAGCGTAACATTCTCAGCCGCCTGGCAAACCGGGCACCCGAACCTACCCCACAGCAGGTAGCCCAGCAGCAGTGA
AGATGCAGACTGATACCACCTCCACCGCTGAGCAGTGACCTTCCTCACTTTCTCTTGTCCCAGCTTCTCCCCTGGGGGCCTGAGAGACCC
TCACCTTCCTTCTGCCCATCTTCCATGTTGTAAAGGAACAGCCCCAGTGCACTGGGGGAGGGGAGGGAGTGAGGGGCAGTGGTGCCCTTC
CTGCAGAAGAGACATGCAGCAGTAGCGCTGGCGCCATCTGCAGGAGCTGGCGGGCTGGCCTTCTGGACCCTGGCTTCTCCCCACTGTAAC
GCCTGTTACACACAAACTGTTGTGGGTTCCTGCCAGGCTTGAAGAAAATGATCTGAATTTTTTCCTCCTTTTGGTTTTATTTTGTTGGTT
TATTTTGTGTTTTCTTTTCTCCTTTTTGGGGGGTATTCAGAGTGGGCTGGGCCCCTGGGCGAGACACAGCTACCTCTGTTGGCATCTTTT
TAATACCAGGAACCCAGCGGCTCTAGCCACTGAGCGGCTAAATGAAATAAAGTGGAAAAAAAAAAAAAGGAAAAAACCAAAAGCATAAAA

>In-frame_ENST00000540022_ENST00000544040_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(amino acids)=141AA_start in transcript=204_stop in transcript=629
MSGMGLSTVPDLLLPLLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELL

--------------------------------------------------------------
>In-frame_ENST00000366159_ENST00000544484_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(transcript)=1044nt_BP=73nt
CAAATGGGGGAGTGAGAGGCCATAGCTGTCTGGCATGGGCCTCTCCACCGTGCCTGACCTGCTGCTGCCACTGCTCTTAGAACAAGCTCT
GGTGATTGAGGAACAGCTGCGCCGGGCTGCTTACTTGAACATGTCAGAAGACCCTTCTCACCCTTCCATGGCCCTCAACACCCGCTTTGC
TGAGGTGGAGTGTTTGGCGGAAAGTCATCAGCACCTGTCCAAGGAGTCAATGGCAGGAAACAAGCCAGCCAATGCAGTCCTGCACAAAGT
TCTGAAACAGCTGGAAGAACTGCTGAGTGACATGAAAGCTGATGTGACTCGACTCCCAGCTACCATTGCCCGAATTCCCCCAGTTGCTGT
GAGGTTACAGATGTCAGAGCGTAACATTCTCAGCCGCCTGGCAAACCGGGCACCCGAACCTACCCCACAGCAGGTAGCCCAGCAGCAGTG
AAGATGCAGACTGATACCACCTCCACCGCTGAGCAGTGACCTTCCTCACTTTCTCTTGTCCCAGCTTCTCCCCTGGGGGCCTGAGAGACC
CTCACCTTCCTTCTGCCCATCTTCCATGTTGTAAAGGAACAGCCCCAGTGCACTGGGGGAGGGGAGGGAGTGAGGGGCAGTGGTGCCCTT
CCTGCAGAAGAGACATGCAGCAGTAGCGCTGGCGCCATCTGCAGGAGCTGGCGGGCTGGCCTTCTGGACCCTGGCTTCTCCCCACTGTAA
CGCCTGTTACACACAAACTGTTGTGGGTTCCTGCCAGGCTTGAAGAAAATGATCTGAATTTTTTCCTCCTTTTGGTTTTATTTTGTTGGT
TTATTTTGTGTTTTCTTTTCTCCTTTTTGGGGGGTATTCAGAGTGGGCTGGGCCCCTGGGCGAGACACAGCTACCTCTGTTGGCATCTTT
TTAATACCAGGAACCCAGCGGCTCTAGCCACTGAGCGGCTAAATGAAATAAAGTGGAAAAAAAAAAAAAGGAAAAAACCAAAAGCATAAA

>In-frame_ENST00000366159_ENST00000544484_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(amino acids)=141AA_start in transcript=25_stop in transcript=450
MSGMGLSTVPDLLLPLLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELL

--------------------------------------------------------------
>In-frame_ENST00000366159_ENST00000357008_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(transcript)=1044nt_BP=73nt
CAAATGGGGGAGTGAGAGGCCATAGCTGTCTGGCATGGGCCTCTCCACCGTGCCTGACCTGCTGCTGCCACTGCTCTTAGAACAAGCTCT
GGTGATTGAGGAACAGCTGCGCCGGGCTGCTTACTTGAACATGTCAGAAGACCCTTCTCACCCTTCCATGGCCCTCAACACCCGCTTTGC
TGAGGTGGAGTGTTTGGCGGAAAGTCATCAGCACCTGTCCAAGGAGTCAATGGCAGGAAACAAGCCAGCCAATGCAGTCCTGCACAAAGT
TCTGAAACAGCTGGAAGAACTGCTGAGTGACATGAAAGCTGATGTGACTCGACTCCCAGCTACCATTGCCCGAATTCCCCCAGTTGCTGT
GAGGTTACAGATGTCAGAGCGTAACATTCTCAGCCGCCTGGCAAACCGGGCACCCGAACCTACCCCACAGCAGGTAGCCCAGCAGCAGTG
AAGATGCAGACTGATACCACCTCCACCGCTGAGCAGTGACCTTCCTCACTTTCTCTTGTCCCAGCTTCTCCCCTGGGGGCCTGAGAGACC
CTCACCTTCCTTCTGCCCATCTTCCATGTTGTAAAGGAACAGCCCCAGTGCACTGGGGGAGGGGAGGGAGTGAGGGGCAGTGGTGCCCTT
CCTGCAGAAGAGACATGCAGCAGTAGCGCTGGCGCCATCTGCAGGAGCTGGCGGGCTGGCCTTCTGGACCCTGGCTTCTCCCCACTGTAA
CGCCTGTTACACACAAACTGTTGTGGGTTCCTGCCAGGCTTGAAGAAAATGATCTGAATTTTTTCCTCCTTTTGGTTTTATTTTGTTGGT
TTATTTTGTGTTTTCTTTTCTCCTTTTTGGGGGGTATTCAGAGTGGGCTGGGCCCCTGGGCGAGACACAGCTACCTCTGTTGGCATCTTT
TTAATACCAGGAACCCAGCGGCTCTAGCCACTGAGCGGCTAAATGAAATAAAGTGGAAAAAAAAAAAAAGGAAAAAACCAAAAGCATAAA

>In-frame_ENST00000366159_ENST00000357008_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(amino acids)=141AA_start in transcript=25_stop in transcript=450
MSGMGLSTVPDLLLPLLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELL

--------------------------------------------------------------
>In-frame_ENST00000366159_ENST00000309577_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(transcript)=1044nt_BP=73nt
CAAATGGGGGAGTGAGAGGCCATAGCTGTCTGGCATGGGCCTCTCCACCGTGCCTGACCTGCTGCTGCCACTGCTCTTAGAACAAGCTCT
GGTGATTGAGGAACAGCTGCGCCGGGCTGCTTACTTGAACATGTCAGAAGACCCTTCTCACCCTTCCATGGCCCTCAACACCCGCTTTGC
TGAGGTGGAGTGTTTGGCGGAAAGTCATCAGCACCTGTCCAAGGAGTCAATGGCAGGAAACAAGCCAGCCAATGCAGTCCTGCACAAAGT
TCTGAAACAGCTGGAAGAACTGCTGAGTGACATGAAAGCTGATGTGACTCGACTCCCAGCTACCATTGCCCGAATTCCCCCAGTTGCTGT
GAGGTTACAGATGTCAGAGCGTAACATTCTCAGCCGCCTGGCAAACCGGGCACCCGAACCTACCCCACAGCAGGTAGCCCAGCAGCAGTG
AAGATGCAGACTGATACCACCTCCACCGCTGAGCAGTGACCTTCCTCACTTTCTCTTGTCCCAGCTTCTCCCCTGGGGGCCTGAGAGACC
CTCACCTTCCTTCTGCCCATCTTCCATGTTGTAAAGGAACAGCCCCAGTGCACTGGGGGAGGGGAGGGAGTGAGGGGCAGTGGTGCCCTT
CCTGCAGAAGAGACATGCAGCAGTAGCGCTGGCGCCATCTGCAGGAGCTGGCGGGCTGGCCTTCTGGACCCTGGCTTCTCCCCACTGTAA
CGCCTGTTACACACAAACTGTTGTGGGTTCCTGCCAGGCTTGAAGAAAATGATCTGAATTTTTTCCTCCTTTTGGTTTTATTTTGTTGGT
TTATTTTGTGTTTTCTTTTCTCCTTTTTGGGGGGTATTCAGAGTGGGCTGGGCCCCTGGGCGAGACACAGCTACCTCTGTTGGCATCTTT
TTAATACCAGGAACCCAGCGGCTCTAGCCACTGAGCGGCTAAATGAAATAAAGTGGAAAAAAAAAAAAAGGAAAAAACCAAAAGCATAAA

>In-frame_ENST00000366159_ENST00000309577_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(amino acids)=141AA_start in transcript=25_stop in transcript=450
MSGMGLSTVPDLLLPLLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELL

--------------------------------------------------------------
>In-frame_ENST00000366159_ENST00000544040_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(transcript)=1044nt_BP=73nt
CAAATGGGGGAGTGAGAGGCCATAGCTGTCTGGCATGGGCCTCTCCACCGTGCCTGACCTGCTGCTGCCACTGCTCTTAGAACAAGCTCT
GGTGATTGAGGAACAGCTGCGCCGGGCTGCTTACTTGAACATGTCAGAAGACCCTTCTCACCCTTCCATGGCCCTCAACACCCGCTTTGC
TGAGGTGGAGTGTTTGGCGGAAAGTCATCAGCACCTGTCCAAGGAGTCAATGGCAGGAAACAAGCCAGCCAATGCAGTCCTGCACAAAGT
TCTGAAACAGCTGGAAGAACTGCTGAGTGACATGAAAGCTGATGTGACTCGACTCCCAGCTACCATTGCCCGAATTCCCCCAGTTGCTGT
GAGGTTACAGATGTCAGAGCGTAACATTCTCAGCCGCCTGGCAAACCGGGCACCCGAACCTACCCCACAGCAGGTAGCCCAGCAGCAGTG
AAGATGCAGACTGATACCACCTCCACCGCTGAGCAGTGACCTTCCTCACTTTCTCTTGTCCCAGCTTCTCCCCTGGGGGCCTGAGAGACC
CTCACCTTCCTTCTGCCCATCTTCCATGTTGTAAAGGAACAGCCCCAGTGCACTGGGGGAGGGGAGGGAGTGAGGGGCAGTGGTGCCCTT
CCTGCAGAAGAGACATGCAGCAGTAGCGCTGGCGCCATCTGCAGGAGCTGGCGGGCTGGCCTTCTGGACCCTGGCTTCTCCCCACTGTAA
CGCCTGTTACACACAAACTGTTGTGGGTTCCTGCCAGGCTTGAAGAAAATGATCTGAATTTTTTCCTCCTTTTGGTTTTATTTTGTTGGT
TTATTTTGTGTTTTCTTTTCTCCTTTTTGGGGGGTATTCAGAGTGGGCTGGGCCCCTGGGCGAGACACAGCTACCTCTGTTGGCATCTTT
TTAATACCAGGAACCCAGCGGCTCTAGCCACTGAGCGGCTAAATGAAATAAAGTGGAAAAAAAAAAAAAGGAAAAAACCAAAAGCATAAA

>In-frame_ENST00000366159_ENST00000544040_TCGA-D3-A2JN-06A_TNFRSF1A_chr12_6450942_-_CHD4_chr12_6682435_length(amino acids)=141AA_start in transcript=25_stop in transcript=450
MSGMGLSTVPDLLLPLLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELL

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Fusion Gene PPI Analysis for TNFRSF1A-CHD4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TNFRSF1A-CHD4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TNFRSF1A-CHD4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTNFRSF1AC1275126TNF receptor-associated periodic fever syndrome (TRAPS)7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneTNFRSF1AC0011570Mental Depression5PSYGENET
HgeneTNFRSF1AC0011581Depressive disorder5PSYGENET
HgeneTNFRSF1AC0026769Multiple Sclerosis2CTD_human
HgeneTNFRSF1AC0751324Multiple Sclerosis, Acute Fulminating2CTD_human
HgeneTNFRSF1AC0002152Alloxan Diabetes1CTD_human
HgeneTNFRSF1AC0003123Anorexia1CTD_human
HgeneTNFRSF1AC0004364Autoimmune Diseases1CTD_human
HgeneTNFRSF1AC0006625Cachexia1CTD_human
HgeneTNFRSF1AC0007786Brain Ischemia1CTD_human
HgeneTNFRSF1AC0008312Primary biliary cirrhosis1CTD_human
HgeneTNFRSF1AC0010674Cystic Fibrosis1CTD_human
HgeneTNFRSF1AC0011853Diabetes Mellitus, Experimental1CTD_human
HgeneTNFRSF1AC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneTNFRSF1AC0015967Fever1CTD_human
HgeneTNFRSF1AC0018801Heart failure1CTD_human
HgeneTNFRSF1AC0018802Congestive heart failure1CTD_human
HgeneTNFRSF1AC0020517Hypersensitivity1CTD_human
HgeneTNFRSF1AC0023212Left-Sided Heart Failure1CTD_human
HgeneTNFRSF1AC0023892Biliary cirrhosis1CTD_human
HgeneTNFRSF1AC0032285Pneumonia1CTD_human
HgeneTNFRSF1AC0032300Lobar Pneumonia1CTD_human
HgeneTNFRSF1AC0036341Schizophrenia1PSYGENET
HgeneTNFRSF1AC0038433Streptozotocin Diabetes1CTD_human
HgeneTNFRSF1AC0149910Intermittent joint effusion1ORPHANET
HgeneTNFRSF1AC0235527Heart Failure, Right-Sided1CTD_human
HgeneTNFRSF1AC0238065Secondary Biliary Cholangitis1CTD_human
HgeneTNFRSF1AC0242706Hyperoxia1CTD_human
HgeneTNFRSF1AC0273115Lung Injury1CTD_human
HgeneTNFRSF1AC0392164Pulmonary Cystic Fibrosis1CTD_human
HgeneTNFRSF1AC0751422Hereditary Autoinflammatory Diseases1GENOMICS_ENGLAND
HgeneTNFRSF1AC0887898Experimental Lung Inflammation1CTD_human
HgeneTNFRSF1AC0917798Cerebral Ischemia1CTD_human
HgeneTNFRSF1AC1527304Allergic Reaction1CTD_human
HgeneTNFRSF1AC1527396Fibrocystic Disease of Pancreas1CTD_human
HgeneTNFRSF1AC1959583Myocardial Failure1CTD_human
HgeneTNFRSF1AC1961112Heart Decompensation1CTD_human
HgeneTNFRSF1AC2350344Chronic Lung Injury1CTD_human
HgeneTNFRSF1AC3714636Pneumonitis1CTD_human
HgeneTNFRSF1AC3860213Autoinflammatory disorder1GENOMICS_ENGLAND
HgeneTNFRSF1AC4551595Biliary Cirrhosis, Primary, 11CTD_human
TgeneCHD4C4310688SIFRIM-HITZ-WEISS SYNDROME2GENOMICS_ENGLAND;UNIPROT
TgeneCHD4C0004352Autistic Disorder1CTD_human
TgeneCHD4C0008073Developmental Disabilities1CTD_human
TgeneCHD4C0014170Endometrial Neoplasms1CTD_human
TgeneCHD4C0036341Schizophrenia1CTD_human
TgeneCHD4C0085996Child Development Deviations1CTD_human
TgeneCHD4C0085997Child Development Disorders, Specific1CTD_human
TgeneCHD4C0476089Endometrial Carcinoma1CTD_human