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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TNKS-CCDC109B (FusionGDB2 ID:92086)

Fusion Gene Summary for TNKS-CCDC109B

check button Fusion gene summary
Fusion gene informationFusion gene name: TNKS-CCDC109B
Fusion gene ID: 92086
HgeneTgene
Gene symbol

TNKS

CCDC109B

Gene ID

8658

55013

Gene nametankyrasemitochondrial calcium uniporter dominant negative subunit beta
SynonymsARTD5|PARP-5a|PARP5A|PARPL|TIN1|TINF1|TNKS1|pART5CCDC109B
Cytomap

8p23.1

4q25

Type of geneprotein-codingprotein-coding
Descriptionpoly [ADP-ribose] polymerase tankyrase-1ADP-ribosyltransferase diphtheria toxin-like 5TANK1TNKS-1TRF1-interacting ankyrin-related ADP-ribose polymerase 1poly [ADP-ribose] polymerase 5Aprotein poly-ADP-ribosyltransferase tankyrase-1tankyrase Itankycalcium uniporter regulatory subunit MCUb, mitochondrialcoiled-coil domain containing 109Bcoiled-coil domain-containing protein 109Bmitochondrial calcium uniporter dominant negative beta subunitmitochondrial calcium uniporter regulatory subunit MCUb
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000520408, ENST00000310430, 
ENST00000518281, ENST00000522110, 
ENST00000518027, 		ENST00000394650, 
ENST00000515114, 
Fusion gene scores* DoF score13 X 8 X 8=8322 X 2 X 2=8
# samples 142
** MAII scorelog2(14/832*10)=-2.57115670119613
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: TNKS [Title/Abstract] AND CCDC109B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTNKS(9437893)-CCDC109B(110603737), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNKS

GO:0000209

protein polyubiquitination

19759537|21478859

HgeneTNKS

GO:0006471

protein ADP-ribosylation

9822378|15133513|21270334

HgeneTNKS

GO:0018105

peptidyl-serine phosphorylation

17026964

HgeneTNKS

GO:0018107

peptidyl-threonine phosphorylation

17026964

HgeneTNKS

GO:0032212

positive regulation of telomere maintenance via telomerase

12782650|18221737

HgeneTNKS

GO:0045944

positive regulation of transcription by RNA polymerase II

19245366

HgeneTNKS

GO:0051973

positive regulation of telomerase activity

12782650

HgeneTNKS

GO:0070212

protein poly-ADP-ribosylation

9822378|16076287|25043379

HgeneTNKS

GO:0070213

protein auto-ADP-ribosylation

9822378|15133513|19759537|21478859

HgeneTNKS

GO:1904355

positive regulation of telomere capping

21531765

HgeneTNKS

GO:1904743

negative regulation of telomeric DNA binding

9822378


check buttonFusion gene breakpoints across TNKS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CCDC109B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-A4YVTNKSchr8

9437893

+CCDC109Bchr4

110603737

+


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Fusion Gene ORF analysis for TNKS-CCDC109B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000520408ENST00000394650TNKSchr8

9437893

+CCDC109Bchr4

110603737

+
5CDS-intronENST00000520408ENST00000515114TNKSchr8

9437893

+CCDC109Bchr4

110603737

+
In-frameENST00000310430ENST00000394650TNKSchr8

9437893

+CCDC109Bchr4

110603737

+
5CDS-intronENST00000310430ENST00000515114TNKSchr8

9437893

+CCDC109Bchr4

110603737

+
In-frameENST00000518281ENST00000394650TNKSchr8

9437893

+CCDC109Bchr4

110603737

+
5CDS-intronENST00000518281ENST00000515114TNKSchr8

9437893

+CCDC109Bchr4

110603737

+
intron-3CDSENST00000522110ENST00000394650TNKSchr8

9437893

+CCDC109Bchr4

110603737

+
intron-intronENST00000522110ENST00000515114TNKSchr8

9437893

+CCDC109Bchr4

110603737

+
intron-3CDSENST00000518027ENST00000394650TNKSchr8

9437893

+CCDC109Bchr4

110603737

+
intron-intronENST00000518027ENST00000515114TNKSchr8

9437893

+CCDC109Bchr4

110603737

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000520408TNKSchr89437893+ENST00000394650CCDC109Bchr4110603737+2610924261483485
ENST00000310430TNKSchr89437893+ENST00000394650CCDC109Bchr4110603737+2610924261483485
ENST00000518281TNKSchr89437893+ENST00000394650CCDC109Bchr4110603737+23046184311177248

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000520408ENST00000394650TNKSchr89437893+CCDC109Bchr4110603737+0.0040891670.9959109
ENST00000310430ENST00000394650TNKSchr89437893+CCDC109Bchr4110603737+0.0040891670.9959109
ENST00000518281ENST00000394650TNKSchr89437893+CCDC109Bchr4110603737+0.0008237230.9991762

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Fusion Genomic Features for TNKS-CCDC109B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TNKSchr89437893+CCDC109Bchr4110603737+9.55E-091
TNKSchr89437893+CCDC109Bchr4110603737+9.55E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TNKS-CCDC109B


check button Go to

FGviewer for the breakpoints of chr8:9437893-chr4:110603737

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227109_161299.33333333333331328.0Compositional biasSer-rich
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+22720_83299.33333333333331328.0Compositional biasPro-rich
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+2279_14299.33333333333331328.0Compositional biasPoly-His
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227181_209299.33333333333331328.0RepeatANK 1
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227215_244299.33333333333331328.0RepeatANK 2
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227248_277299.33333333333331328.0RepeatANK 3
TgeneCCDC109Bchr8:9437893chr4:110603737ENST0000039465038179_210150.33333333333334337.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC109Bchr8:9437893chr4:110603737ENST0000039465038297_323150.33333333333334337.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC109Bchr8:9437893chr4:110603737ENST0000039465038220_240150.33333333333334337.0TransmembraneHelical
TgeneCCDC109Bchr8:9437893chr4:110603737ENST0000039465038250_270150.33333333333334337.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+2271030_1089299.33333333333331328.0DomainSAM
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+2271112_1317299.33333333333331328.0DomainPARP catalytic
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227281_310299.33333333333331328.0RepeatANK 4
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227335_364299.33333333333331328.0RepeatANK 5
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227368_397299.33333333333331328.0RepeatANK 6
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227401_430299.33333333333331328.0RepeatANK 7
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227434_463299.33333333333331328.0RepeatANK 8
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227521_553299.33333333333331328.0RepeatANK 9
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227557_586299.33333333333331328.0RepeatANK 10
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227590_619299.33333333333331328.0RepeatANK 11
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227621_647299.33333333333331328.0RepeatANK 12
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227649_679299.33333333333331328.0RepeatANK 13
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227683_712299.33333333333331328.0RepeatANK 14
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227716_745299.33333333333331328.0RepeatANK 15
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227749_778299.33333333333331328.0RepeatANK 16
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227782_810299.33333333333331328.0RepeatANK 17
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227836_865299.33333333333331328.0RepeatANK 18
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227869_898299.33333333333331328.0RepeatANK 19
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227902_931299.33333333333331328.0RepeatANK 20
HgeneTNKSchr8:9437893chr4:110603737ENST00000310430+227935_964299.33333333333331328.0RepeatANK 21


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Fusion Gene Sequence for TNKS-CCDC109B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000520408_ENST00000394650_TCGA-D7-A4YV_TNKS_chr8_9437893_+_CCDC109B_chr4_110603737_length(transcript)=2610nt_BP=924nt
AGTGACAGTGCTAGGGGAGTCCGAAGATGGCGGCGTCGCGTCGCTCTCAGCATCATCACCACCATCATCAACAACAGCTCCAGCCCGCCC
CAGGGGCTTCAGCGCCGCCGCCGCCACCTCCTCCCCCACTCAGCCCTGGCCTGGCCCCGGGGACCACCCCAGCCTCTCCCACGGCCAGCG
GCCTGGCCCCCTTCGCCTCCCCGCGGCACGGCCTAGCGCTGCCGGAGGGGGATGGCAGTCGGGATCCGCCCGACAGGCCCCGATCCCCGG
ACCCGGTTGACGGTACCAGCTGTTGCAGTACCACCAGCACAATCTGTACCGTCGCCGCCGCTCCCGTGGTCCCAGCGGTTTCTACTTCAT
CTGCCGCTGGGGTCGCTCCCAACCCAGCCGGCAGTGGCAGTAACAATTCACCGTCGTCCTCTTCTTCCCCGACTTCTTCCTCATCTTCCT
CTCCATCCTCCCCTGGATCGAGCTTGGCGGAGAGCCCCGAGGCGGCCGGAGTTAGCAGCACAGCACCACTGGGGCCTGGGGCAGCAGGAC
CTGGGACAGGGGTCCCAGCAGTGAGCGGGGCCCTACGGGAACTGCTGGAGGCCTGTCGCAATGGGGACGTGTCCCGGGTAAAGAGGCTGG
TGGACGCGGCAAACGTAAATGCAAAGGACATGGCCGGCCGGAAGTCTTCTCCCCTGCACTTCGCTGCAGGTTTTGGAAGGAAGGATGTTG
TAGAACACTTACTACAGATGGGTGCTAATGTCCACGCTCGTGATGATGGAGGTCTCATCCCGCTTCATAATGCCTGTTCTTTTGGCCATG
CTGAGGTTGTGAGTCTGTTATTGTGCCAAGGAGCTGATCCAAATGCCAGGGATAACTGGAACTATACACCTCTGCATGAAGCTGCTATTA
AAGGGAAGATCGATGTGTGCATTGAAAAACCAAGTAATGAGCACACTGCTGAGATGGAACACATGAAATCTTTGGTTCACAGACTATTTA
CAATCTTGCATTTAGAAGAGTCTCAGAAAAAGAGAGAGCACCATTTACTGGAGAAAATTGACCACCTGAAGGAACAGCTGCAGCCCCTTG
AACAGGTGAAAGCTGGAATAGAAGCTCATTCGGAAGCCAAAACCAGTGGACTCCTGTGGGCTGGATTGGCACTGCTGTCCATTCAGGGTG
GGGCACTGGCCTGGCTCACGTGGTGGGTGTACTCCTGGGATATCATGGAGCCAGTTACATACTTCATCACATTTGCAAATTCTATGGTCT
TTTTTGCATACTTTATAGTCACTCGACAGGATTATACTTACTCAGCTGTTAAGAGTAGGCAATTTCTTCAGTTCTTCCACAAGAAATCAA
AGCAACAGCACTTTGATGTGCAGCAATACAACAAGTTAAAAGAAGACCTTGCTAAGGCTAAAGAATCCCTGAAACAGGCGCGTCATTCTC
TCTGTTTGCAAATGCAAGTAGAAGAACTCAATGAAAAGAATTAATCTTACAGTTTTAAATGTCGTCAGATTTTCCATTATGTATTGATTT
TGCAACTTAGGATGTTTTTGAGTCCCATGGTTCATTTTGATTGTTTAATCTTTGTTATTAAATTCTTGTAAAACAGAAGTATTGTTTGAA
GTTCTCAACTGAGATTTTTACTTTTTGGATTTTTATGACTTGCTAATGTTAGAAAGGGCTTGTATGCGTCTATCAAAGCAACGGTGGCTG
CTGTTAGCTAAAAATCCTTGTCAGCTTGTCCCACGTTTATTCTCTATGTGGAGGTGAAAGGGTCTGTGCTTGGCATTCACTTCCATTCTT
AGACTTAATTTGGAATCATCCTTTTAAAAAAATCAGAGACCAGGTCTTGCCAAATCAAACTCCTGGGCTCAAGCAACCCTCCTGCCTCAA
CCTCCCACGGAATCGTCTTGTCATTAACTTCTTTTTTTAATATGCAGTAGTTGGGAGTAAGATCTTTTTATCATTTATCAAAAAGGCATA
AATGTTCCACCAACCATAAAGTATAGTTGGTACTTTTTGAACTTCAACTGAAACAGTGTATATAAACGATTGCTTTTGAACCTGCAAATC
ACAAGTTTCAGGTATCGAAGCCAAAACAGTTAACTTTCTTCAGCCTCTGGCAGATTATTAACAAAACAGTATTATTCAGATTCTATATCA
TATTAATAAGAATTGAACCTTGAAAGTAACATCTGTTATTCTATTAATGTGATTGTGTGTGAATGGGTCTGATGACTGTTGGACTGTTTG
TAGGAACTTAACATGGAAGATGCTGACAGAATCAGATTTTGCAGGTGTTCAACCTATAGTGGCTAAGAATTATGTTTTCTATTTCATCCT
CAGAATGCCATACAACAATTCTGGAATGCTGATTTTTTTTAAAGTAGGAATTAAAGTCATACACAAAATGTGGTAATTCATATGTAGATG
AAATATTAAACATTTAAATGACCGAGTAAAAAACATCTATCAATTACACAAATGAACAAGAATGTGAGTTAGAAAAATGTAATAAAATAT
GAATTTCGAATATTTTATTAAGGGATGATTTAATTCCTGGATTTCAAAAACCTTTAAAAACATCAAACAATAAACTTTTATAAAAAAGTG

>In-frame_ENST00000520408_ENST00000394650_TCGA-D7-A4YV_TNKS_chr8_9437893_+_CCDC109B_chr4_110603737_length(amino acids)=485AA_start in transcript=26_stop in transcript=1483
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCC
STTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS
GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLC
QGADPNARDNWNYTPLHEAAIKGKIDVCIEKPSNEHTAEMEHMKSLVHRLFTILHLEESQKKREHHLLEKIDHLKEQLQPLEQVKAGIEA
HSEAKTSGLLWAGLALLSIQGGALAWLTWWVYSWDIMEPVTYFITFANSMVFFAYFIVTRQDYTYSAVKSRQFLQFFHKKSKQQHFDVQQ

--------------------------------------------------------------
>In-frame_ENST00000310430_ENST00000394650_TCGA-D7-A4YV_TNKS_chr8_9437893_+_CCDC109B_chr4_110603737_length(transcript)=2610nt_BP=924nt
AGTGACAGTGCTAGGGGAGTCCGAAGATGGCGGCGTCGCGTCGCTCTCAGCATCATCACCACCATCATCAACAACAGCTCCAGCCCGCCC
CAGGGGCTTCAGCGCCGCCGCCGCCACCTCCTCCCCCACTCAGCCCTGGCCTGGCCCCGGGGACCACCCCAGCCTCTCCCACGGCCAGCG
GCCTGGCCCCCTTCGCCTCCCCGCGGCACGGCCTAGCGCTGCCGGAGGGGGATGGCAGTCGGGATCCGCCCGACAGGCCCCGATCCCCGG
ACCCGGTTGACGGTACCAGCTGTTGCAGTACCACCAGCACAATCTGTACCGTCGCCGCCGCTCCCGTGGTCCCAGCGGTTTCTACTTCAT
CTGCCGCTGGGGTCGCTCCCAACCCAGCCGGCAGTGGCAGTAACAATTCACCGTCGTCCTCTTCTTCCCCGACTTCTTCCTCATCTTCCT
CTCCATCCTCCCCTGGATCGAGCTTGGCGGAGAGCCCCGAGGCGGCCGGAGTTAGCAGCACAGCACCACTGGGGCCTGGGGCAGCAGGAC
CTGGGACAGGGGTCCCAGCAGTGAGCGGGGCCCTACGGGAACTGCTGGAGGCCTGTCGCAATGGGGACGTGTCCCGGGTAAAGAGGCTGG
TGGACGCGGCAAACGTAAATGCAAAGGACATGGCCGGCCGGAAGTCTTCTCCCCTGCACTTCGCTGCAGGTTTTGGAAGGAAGGATGTTG
TAGAACACTTACTACAGATGGGTGCTAATGTCCACGCTCGTGATGATGGAGGTCTCATCCCGCTTCATAATGCCTGTTCTTTTGGCCATG
CTGAGGTTGTGAGTCTGTTATTGTGCCAAGGAGCTGATCCAAATGCCAGGGATAACTGGAACTATACACCTCTGCATGAAGCTGCTATTA
AAGGGAAGATCGATGTGTGCATTGAAAAACCAAGTAATGAGCACACTGCTGAGATGGAACACATGAAATCTTTGGTTCACAGACTATTTA
CAATCTTGCATTTAGAAGAGTCTCAGAAAAAGAGAGAGCACCATTTACTGGAGAAAATTGACCACCTGAAGGAACAGCTGCAGCCCCTTG
AACAGGTGAAAGCTGGAATAGAAGCTCATTCGGAAGCCAAAACCAGTGGACTCCTGTGGGCTGGATTGGCACTGCTGTCCATTCAGGGTG
GGGCACTGGCCTGGCTCACGTGGTGGGTGTACTCCTGGGATATCATGGAGCCAGTTACATACTTCATCACATTTGCAAATTCTATGGTCT
TTTTTGCATACTTTATAGTCACTCGACAGGATTATACTTACTCAGCTGTTAAGAGTAGGCAATTTCTTCAGTTCTTCCACAAGAAATCAA
AGCAACAGCACTTTGATGTGCAGCAATACAACAAGTTAAAAGAAGACCTTGCTAAGGCTAAAGAATCCCTGAAACAGGCGCGTCATTCTC
TCTGTTTGCAAATGCAAGTAGAAGAACTCAATGAAAAGAATTAATCTTACAGTTTTAAATGTCGTCAGATTTTCCATTATGTATTGATTT
TGCAACTTAGGATGTTTTTGAGTCCCATGGTTCATTTTGATTGTTTAATCTTTGTTATTAAATTCTTGTAAAACAGAAGTATTGTTTGAA
GTTCTCAACTGAGATTTTTACTTTTTGGATTTTTATGACTTGCTAATGTTAGAAAGGGCTTGTATGCGTCTATCAAAGCAACGGTGGCTG
CTGTTAGCTAAAAATCCTTGTCAGCTTGTCCCACGTTTATTCTCTATGTGGAGGTGAAAGGGTCTGTGCTTGGCATTCACTTCCATTCTT
AGACTTAATTTGGAATCATCCTTTTAAAAAAATCAGAGACCAGGTCTTGCCAAATCAAACTCCTGGGCTCAAGCAACCCTCCTGCCTCAA
CCTCCCACGGAATCGTCTTGTCATTAACTTCTTTTTTTAATATGCAGTAGTTGGGAGTAAGATCTTTTTATCATTTATCAAAAAGGCATA
AATGTTCCACCAACCATAAAGTATAGTTGGTACTTTTTGAACTTCAACTGAAACAGTGTATATAAACGATTGCTTTTGAACCTGCAAATC
ACAAGTTTCAGGTATCGAAGCCAAAACAGTTAACTTTCTTCAGCCTCTGGCAGATTATTAACAAAACAGTATTATTCAGATTCTATATCA
TATTAATAAGAATTGAACCTTGAAAGTAACATCTGTTATTCTATTAATGTGATTGTGTGTGAATGGGTCTGATGACTGTTGGACTGTTTG
TAGGAACTTAACATGGAAGATGCTGACAGAATCAGATTTTGCAGGTGTTCAACCTATAGTGGCTAAGAATTATGTTTTCTATTTCATCCT
CAGAATGCCATACAACAATTCTGGAATGCTGATTTTTTTTAAAGTAGGAATTAAAGTCATACACAAAATGTGGTAATTCATATGTAGATG
AAATATTAAACATTTAAATGACCGAGTAAAAAACATCTATCAATTACACAAATGAACAAGAATGTGAGTTAGAAAAATGTAATAAAATAT
GAATTTCGAATATTTTATTAAGGGATGATTTAATTCCTGGATTTCAAAAACCTTTAAAAACATCAAACAATAAACTTTTATAAAAAAGTG

>In-frame_ENST00000310430_ENST00000394650_TCGA-D7-A4YV_TNKS_chr8_9437893_+_CCDC109B_chr4_110603737_length(amino acids)=485AA_start in transcript=26_stop in transcript=1483
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCC
STTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS
GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLC
QGADPNARDNWNYTPLHEAAIKGKIDVCIEKPSNEHTAEMEHMKSLVHRLFTILHLEESQKKREHHLLEKIDHLKEQLQPLEQVKAGIEA
HSEAKTSGLLWAGLALLSIQGGALAWLTWWVYSWDIMEPVTYFITFANSMVFFAYFIVTRQDYTYSAVKSRQFLQFFHKKSKQQHFDVQQ

--------------------------------------------------------------
>In-frame_ENST00000518281_ENST00000394650_TCGA-D7-A4YV_TNKS_chr8_9437893_+_CCDC109B_chr4_110603737_length(transcript)=2304nt_BP=618nt
AATACCGTTGATAAACTGCTATGTGTGCCTGGATTGCCTTTGTCTTGACAAATTGTGTGAGACAAGTGAATCTCTCCATTATCTTTTTAT
TTTCTTTTGACACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTATAGGGGCGCGATCTCGGCTCATTGCAAGCTCCGCCTCCCGGGTTCA
CGCCATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGACTACAGGCGCCCGCCACCACGCAGGGCTAATTTTTTGTATATTTAGTAGAGAC
GGGTTTCACCATGTTAGCTAGGATGGTCTCGATTTCCTGACCTCGTGATCCGCCTGCTTCGGCCTCCCTAAATTACAGGTGTGAGCCACC
GCGCCCGGCGGATAATTTTTTAAGAGGAACAAGGTTTTGGAAGGAAGGATGTTGTAGAACACTTACTACAGATGGGTGCTAATGTCCACG
CTCGTGATGATGGAGGTCTCATCCCGCTTCATAATGCCTGTTCTTTTGGCCATGCTGAGGTTGTGAGTCTGTTATTGTGCCAAGGAGCTG
ATCCAAATGCCAGGGATAACTGGAACTATACACCTCTGCATGAAGCTGCTATTAAAGGGAAGATCGATGTGTGCATTGAAAAACCAAGTA
ATGAGCACACTGCTGAGATGGAACACATGAAATCTTTGGTTCACAGACTATTTACAATCTTGCATTTAGAAGAGTCTCAGAAAAAGAGAG
AGCACCATTTACTGGAGAAAATTGACCACCTGAAGGAACAGCTGCAGCCCCTTGAACAGGTGAAAGCTGGAATAGAAGCTCATTCGGAAG
CCAAAACCAGTGGACTCCTGTGGGCTGGATTGGCACTGCTGTCCATTCAGGGTGGGGCACTGGCCTGGCTCACGTGGTGGGTGTACTCCT
GGGATATCATGGAGCCAGTTACATACTTCATCACATTTGCAAATTCTATGGTCTTTTTTGCATACTTTATAGTCACTCGACAGGATTATA
CTTACTCAGCTGTTAAGAGTAGGCAATTTCTTCAGTTCTTCCACAAGAAATCAAAGCAACAGCACTTTGATGTGCAGCAATACAACAAGT
TAAAAGAAGACCTTGCTAAGGCTAAAGAATCCCTGAAACAGGCGCGTCATTCTCTCTGTTTGCAAATGCAAGTAGAAGAACTCAATGAAA
AGAATTAATCTTACAGTTTTAAATGTCGTCAGATTTTCCATTATGTATTGATTTTGCAACTTAGGATGTTTTTGAGTCCCATGGTTCATT
TTGATTGTTTAATCTTTGTTATTAAATTCTTGTAAAACAGAAGTATTGTTTGAAGTTCTCAACTGAGATTTTTACTTTTTGGATTTTTAT
GACTTGCTAATGTTAGAAAGGGCTTGTATGCGTCTATCAAAGCAACGGTGGCTGCTGTTAGCTAAAAATCCTTGTCAGCTTGTCCCACGT
TTATTCTCTATGTGGAGGTGAAAGGGTCTGTGCTTGGCATTCACTTCCATTCTTAGACTTAATTTGGAATCATCCTTTTAAAAAAATCAG
AGACCAGGTCTTGCCAAATCAAACTCCTGGGCTCAAGCAACCCTCCTGCCTCAACCTCCCACGGAATCGTCTTGTCATTAACTTCTTTTT
TTAATATGCAGTAGTTGGGAGTAAGATCTTTTTATCATTTATCAAAAAGGCATAAATGTTCCACCAACCATAAAGTATAGTTGGTACTTT
TTGAACTTCAACTGAAACAGTGTATATAAACGATTGCTTTTGAACCTGCAAATCACAAGTTTCAGGTATCGAAGCCAAAACAGTTAACTT
TCTTCAGCCTCTGGCAGATTATTAACAAAACAGTATTATTCAGATTCTATATCATATTAATAAGAATTGAACCTTGAAAGTAACATCTGT
TATTCTATTAATGTGATTGTGTGTGAATGGGTCTGATGACTGTTGGACTGTTTGTAGGAACTTAACATGGAAGATGCTGACAGAATCAGA
TTTTGCAGGTGTTCAACCTATAGTGGCTAAGAATTATGTTTTCTATTTCATCCTCAGAATGCCATACAACAATTCTGGAATGCTGATTTT
TTTTAAAGTAGGAATTAAAGTCATACACAAAATGTGGTAATTCATATGTAGATGAAATATTAAACATTTAAATGACCGAGTAAAAAACAT
CTATCAATTACACAAATGAACAAGAATGTGAGTTAGAAAAATGTAATAAAATATGAATTTCGAATATTTTATTAAGGGATGATTTAATTC

>In-frame_ENST00000518281_ENST00000394650_TCGA-D7-A4YV_TNKS_chr8_9437893_+_CCDC109B_chr4_110603737_length(amino acids)=248AA_start in transcript=431_stop in transcript=1177
MGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIEKPSNEHTAEMEHMKSLVHRLFTILHLE
ESQKKREHHLLEKIDHLKEQLQPLEQVKAGIEAHSEAKTSGLLWAGLALLSIQGGALAWLTWWVYSWDIMEPVTYFITFANSMVFFAYFI

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Fusion Gene PPI Analysis for TNKS-CCDC109B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TNKS-CCDC109B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TNKS-CCDC109B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource