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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TNPO2-HOOK2 (FusionGDB2 ID:92158)

Fusion Gene Summary for TNPO2-HOOK2

check button Fusion gene summary
Fusion gene informationFusion gene name: TNPO2-HOOK2
Fusion gene ID: 92158
HgeneTgene
Gene symbol

TNPO2

HOOK2

Gene ID

30000

29911

Gene nametransportin 2hook microtubule tethering protein 2
SynonymsIPO3|KPNB2B|TRN2HK2
Cytomap

19p13.13

19p13.13

Type of geneprotein-codingprotein-coding
Descriptiontransportin-2importin 3karyopherin beta 2b, transportinkaryopherin beta-2btransportin 2 (importin 3, karyopherin beta 2b)protein Hook homolog 2h-hook2hHK2hook homolog 2
Modification date2020031320200327
UniProtAcc.

Q96ED9

Ensembl transtripts involved in fusion geneENST00000425528, ENST00000441499, 
ENST00000356861, ENST00000450764, 
ENST00000592287, ENST00000588216, 
ENST00000589956, 		ENST00000397668, 
ENST00000264827, ENST00000589965, 
Fusion gene scores* DoF score19 X 19 X 8=28889 X 10 X 6=540
# samples 2412
** MAII scorelog2(24/2888*10)=-3.58896443127865
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNPO2 [Title/Abstract] AND HOOK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTNPO2(12822110)-HOOK2(12885711), # samples:3
TNPO2(12834063)-HOOK2(12885711), # samples:3
Anticipated loss of major functional domain due to fusion event.TNPO2-HOOK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TNPO2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HOOK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-37-A5EN-01ATNPO2chr19

12822110

-HOOK2chr19

12885711

-
ChimerDB4LUSCTCGA-85-7950-01ATNPO2chr19

12821435

-HOOK2chr19

12877054

-
ChimerDB4STADTCGA-F1-6875-01ATNPO2chr19

12834063

-HOOK2chr19

12885711

-
ChimerDB4LUSCTCGA-37-A5ENTNPO2chr19

12822110

-HOOK2chr19

12885711

-
ChimerDB4STADTCGA-F1-6875-01ATNPO2chr19

12834063

-HOOK2chr19

12885711

-
ChimerDB4LUSCTCGA-37-A5EN-01ATNPO2chr19

12822110

-HOOK2chr19

12885711

-
ChimerDB4STADTCGA-F1-6875-01ATNPO2chr19

12834063

-HOOK2chr19

12885711

-


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Fusion Gene ORF analysis for TNPO2-HOOK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000425528ENST00000397668TNPO2chr19

12822110

-HOOK2chr19

12885711

-
In-frameENST00000425528ENST00000264827TNPO2chr19

12822110

-HOOK2chr19

12885711

-
5CDS-5UTRENST00000425528ENST00000589965TNPO2chr19

12822110

-HOOK2chr19

12885711

-
In-frameENST00000441499ENST00000397668TNPO2chr19

12822110

-HOOK2chr19

12885711

-
In-frameENST00000441499ENST00000264827TNPO2chr19

12822110

-HOOK2chr19

12885711

-
5CDS-5UTRENST00000441499ENST00000589965TNPO2chr19

12822110

-HOOK2chr19

12885711

-
In-frameENST00000356861ENST00000397668TNPO2chr19

12822110

-HOOK2chr19

12885711

-
In-frameENST00000356861ENST00000264827TNPO2chr19

12822110

-HOOK2chr19

12885711

-
5CDS-5UTRENST00000356861ENST00000589965TNPO2chr19

12822110

-HOOK2chr19

12885711

-
In-frameENST00000450764ENST00000397668TNPO2chr19

12822110

-HOOK2chr19

12885711

-
In-frameENST00000450764ENST00000264827TNPO2chr19

12822110

-HOOK2chr19

12885711

-
5CDS-5UTRENST00000450764ENST00000589965TNPO2chr19

12822110

-HOOK2chr19

12885711

-
Frame-shiftENST00000592287ENST00000397668TNPO2chr19

12822110

-HOOK2chr19

12885711

-
Frame-shiftENST00000592287ENST00000264827TNPO2chr19

12822110

-HOOK2chr19

12885711

-
5CDS-5UTRENST00000592287ENST00000589965TNPO2chr19

12822110

-HOOK2chr19

12885711

-
Frame-shiftENST00000588216ENST00000397668TNPO2chr19

12822110

-HOOK2chr19

12885711

-
Frame-shiftENST00000588216ENST00000264827TNPO2chr19

12822110

-HOOK2chr19

12885711

-
5CDS-5UTRENST00000588216ENST00000589965TNPO2chr19

12822110

-HOOK2chr19

12885711

-
5UTR-3CDSENST00000589956ENST00000397668TNPO2chr19

12822110

-HOOK2chr19

12885711

-
5UTR-3CDSENST00000589956ENST00000264827TNPO2chr19

12822110

-HOOK2chr19

12885711

-
5UTR-5UTRENST00000589956ENST00000589965TNPO2chr19

12822110

-HOOK2chr19

12885711

-
Frame-shiftENST00000425528ENST00000397668TNPO2chr19

12821435

-HOOK2chr19

12877054

-
Frame-shiftENST00000425528ENST00000264827TNPO2chr19

12821435

-HOOK2chr19

12877054

-
5CDS-intronENST00000425528ENST00000589965TNPO2chr19

12821435

-HOOK2chr19

12877054

-
Frame-shiftENST00000441499ENST00000397668TNPO2chr19

12821435

-HOOK2chr19

12877054

-
Frame-shiftENST00000441499ENST00000264827TNPO2chr19

12821435

-HOOK2chr19

12877054

-
5CDS-intronENST00000441499ENST00000589965TNPO2chr19

12821435

-HOOK2chr19

12877054

-
Frame-shiftENST00000356861ENST00000397668TNPO2chr19

12821435

-HOOK2chr19

12877054

-
Frame-shiftENST00000356861ENST00000264827TNPO2chr19

12821435

-HOOK2chr19

12877054

-
5CDS-intronENST00000356861ENST00000589965TNPO2chr19

12821435

-HOOK2chr19

12877054

-
Frame-shiftENST00000450764ENST00000397668TNPO2chr19

12821435

-HOOK2chr19

12877054

-
Frame-shiftENST00000450764ENST00000264827TNPO2chr19

12821435

-HOOK2chr19

12877054

-
5CDS-intronENST00000450764ENST00000589965TNPO2chr19

12821435

-HOOK2chr19

12877054

-
Frame-shiftENST00000592287ENST00000397668TNPO2chr19

12821435

-HOOK2chr19

12877054

-
Frame-shiftENST00000592287ENST00000264827TNPO2chr19

12821435

-HOOK2chr19

12877054

-
5CDS-intronENST00000592287ENST00000589965TNPO2chr19

12821435

-HOOK2chr19

12877054

-
Frame-shiftENST00000588216ENST00000397668TNPO2chr19

12821435

-HOOK2chr19

12877054

-
Frame-shiftENST00000588216ENST00000264827TNPO2chr19

12821435

-HOOK2chr19

12877054

-
5CDS-intronENST00000588216ENST00000589965TNPO2chr19

12821435

-HOOK2chr19

12877054

-
intron-3CDSENST00000589956ENST00000397668TNPO2chr19

12821435

-HOOK2chr19

12877054

-
intron-3CDSENST00000589956ENST00000264827TNPO2chr19

12821435

-HOOK2chr19

12877054

-
intron-intronENST00000589956ENST00000589965TNPO2chr19

12821435

-HOOK2chr19

12877054

-
5UTR-3CDSENST00000425528ENST00000397668TNPO2chr19

12834063

-HOOK2chr19

12885711

-
5UTR-3CDSENST00000425528ENST00000264827TNPO2chr19

12834063

-HOOK2chr19

12885711

-
5UTR-5UTRENST00000425528ENST00000589965TNPO2chr19

12834063

-HOOK2chr19

12885711

-
5UTR-3CDSENST00000441499ENST00000397668TNPO2chr19

12834063

-HOOK2chr19

12885711

-
5UTR-3CDSENST00000441499ENST00000264827TNPO2chr19

12834063

-HOOK2chr19

12885711

-
5UTR-5UTRENST00000441499ENST00000589965TNPO2chr19

12834063

-HOOK2chr19

12885711

-
intron-3CDSENST00000356861ENST00000397668TNPO2chr19

12834063

-HOOK2chr19

12885711

-
intron-3CDSENST00000356861ENST00000264827TNPO2chr19

12834063

-HOOK2chr19

12885711

-
intron-5UTRENST00000356861ENST00000589965TNPO2chr19

12834063

-HOOK2chr19

12885711

-
intron-3CDSENST00000450764ENST00000397668TNPO2chr19

12834063

-HOOK2chr19

12885711

-
intron-3CDSENST00000450764ENST00000264827TNPO2chr19

12834063

-HOOK2chr19

12885711

-
intron-5UTRENST00000450764ENST00000589965TNPO2chr19

12834063

-HOOK2chr19

12885711

-
intron-3CDSENST00000592287ENST00000397668TNPO2chr19

12834063

-HOOK2chr19

12885711

-
intron-3CDSENST00000592287ENST00000264827TNPO2chr19

12834063

-HOOK2chr19

12885711

-
intron-5UTRENST00000592287ENST00000589965TNPO2chr19

12834063

-HOOK2chr19

12885711

-
5UTR-3CDSENST00000588216ENST00000397668TNPO2chr19

12834063

-HOOK2chr19

12885711

-
5UTR-3CDSENST00000588216ENST00000264827TNPO2chr19

12834063

-HOOK2chr19

12885711

-
5UTR-5UTRENST00000588216ENST00000589965TNPO2chr19

12834063

-HOOK2chr19

12885711

-
intron-3CDSENST00000589956ENST00000397668TNPO2chr19

12834063

-HOOK2chr19

12885711

-
intron-3CDSENST00000589956ENST00000264827TNPO2chr19

12834063

-HOOK2chr19

12885711

-
intron-5UTRENST00000589956ENST00000589965TNPO2chr19

12834063

-HOOK2chr19

12885711

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TNPO2-HOOK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TNPO2-HOOK2


check button Go to

FGviewer for the breakpoints of chr19:12822110-chr19:12885711

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HOOK2

Q96ED9

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. {ECO:0000269|PubMed:17140400, ECO:0000269|PubMed:17540036, ECO:0000269|PubMed:18799622}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-112531_99372.33333333333331500.3333333333333DomainNote=Importin N-terminal
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-122631_99372.33333333333331509.0DomainNote=Importin N-terminal
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-122631_99372.33333333333331499.0DomainNote=Importin N-terminal
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-102431_99372.33333333333331150.0DomainNote=Importin N-terminal
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-122531_99372.3333333333333888.0DomainNote=Importin N-terminal
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-112531_99372.3333333333333901.6666666666666DomainNote=Importin N-terminal
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-1125127_164372.33333333333331500.3333333333333RepeatHEAT 4
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-1125171_201372.33333333333331500.3333333333333RepeatHEAT 5
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-1125214_241372.33333333333331500.3333333333333RepeatHEAT 6
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-1125253_280372.33333333333331500.3333333333333RepeatHEAT 7
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-112541_79372.33333333333331500.3333333333333RepeatHEAT 2
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-112588_121372.33333333333331500.3333333333333RepeatHEAT 3
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-11259_36372.33333333333331500.3333333333333RepeatHEAT 1
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-1226127_164372.33333333333331509.0RepeatHEAT 4
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-1226171_201372.33333333333331509.0RepeatHEAT 5
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-1226214_241372.33333333333331509.0RepeatHEAT 6
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-1226253_280372.33333333333331509.0RepeatHEAT 7
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-122641_79372.33333333333331509.0RepeatHEAT 2
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-122688_121372.33333333333331509.0RepeatHEAT 3
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-12269_36372.33333333333331509.0RepeatHEAT 1
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-1226127_164372.33333333333331499.0RepeatHEAT 4
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-1226171_201372.33333333333331499.0RepeatHEAT 5
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-1226214_241372.33333333333331499.0RepeatHEAT 6
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-1226253_280372.33333333333331499.0RepeatHEAT 7
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-122641_79372.33333333333331499.0RepeatHEAT 2
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-122688_121372.33333333333331499.0RepeatHEAT 3
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-12269_36372.33333333333331499.0RepeatHEAT 1
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-1024127_164372.33333333333331150.0RepeatHEAT 4
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-1024171_201372.33333333333331150.0RepeatHEAT 5
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-1024214_241372.33333333333331150.0RepeatHEAT 6
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-1024253_280372.33333333333331150.0RepeatHEAT 7
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-102441_79372.33333333333331150.0RepeatHEAT 2
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-102488_121372.33333333333331150.0RepeatHEAT 3
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-10249_36372.33333333333331150.0RepeatHEAT 1
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-1225127_164372.3333333333333888.0RepeatHEAT 4
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-1225171_201372.3333333333333888.0RepeatHEAT 5
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-1225214_241372.3333333333333888.0RepeatHEAT 6
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-1225253_280372.3333333333333888.0RepeatHEAT 7
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-122541_79372.3333333333333888.0RepeatHEAT 2
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-122588_121372.3333333333333888.0RepeatHEAT 3
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-12259_36372.3333333333333888.0RepeatHEAT 1
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-1125127_164372.3333333333333901.6666666666666RepeatHEAT 4
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-1125171_201372.3333333333333901.6666666666666RepeatHEAT 5
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-1125214_241372.3333333333333901.6666666666666RepeatHEAT 6
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-1125253_280372.3333333333333901.6666666666666RepeatHEAT 7
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-112541_79372.3333333333333901.6666666666666RepeatHEAT 2
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-112588_121372.3333333333333901.6666666666666RepeatHEAT 3
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-11259_36372.3333333333333901.6666666666666RepeatHEAT 1
TgeneHOOK2chr19:12822110chr19:12885711ENST00000264827022180_42715.0718.0Coiled coilOntology_term=ECO:0000255
TgeneHOOK2chr19:12822110chr19:12885711ENST00000264827022455_60715.0718.0Coiled coilOntology_term=ECO:0000255
TgeneHOOK2chr19:12822110chr19:12885711ENST00000397668023180_42715.0720.0Coiled coilOntology_term=ECO:0000255
TgeneHOOK2chr19:12822110chr19:12885711ENST00000397668023455_60715.0720.0Coiled coilOntology_term=ECO:0000255
TgeneHOOK2chr19:12822110chr19:12885711ENST00000264827022533_71915.0718.0RegionNote=Required for localization to the centrosome and induction of aggresome formation
TgeneHOOK2chr19:12822110chr19:12885711ENST00000397668023533_71915.0720.0RegionNote=Required for localization to the centrosome and induction of aggresome formation

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-1125296_386372.33333333333331500.3333333333333RepeatHEAT 8
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-1125394_422372.33333333333331500.3333333333333RepeatHEAT 9
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-1125434_461372.33333333333331500.3333333333333RepeatHEAT 10
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-1125475_508372.33333333333331500.3333333333333RepeatHEAT 11
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-1125516_549372.33333333333331500.3333333333333RepeatHEAT 12
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-1125557_595372.33333333333331500.3333333333333RepeatHEAT 13
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-1125603_654372.33333333333331500.3333333333333RepeatHEAT 14
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-1125665_696372.33333333333331500.3333333333333RepeatHEAT 15
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-1125704_737372.33333333333331500.3333333333333RepeatHEAT 16
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-1125745_790372.33333333333331500.3333333333333RepeatHEAT 17
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-1125798_831372.33333333333331500.3333333333333RepeatHEAT 18
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-1125840_871372.33333333333331500.3333333333333RepeatHEAT 19
HgeneTNPO2chr19:12822110chr19:12885711ENST00000356861-1125874_894372.33333333333331500.3333333333333RepeatHEAT 20
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-1226296_386372.33333333333331509.0RepeatHEAT 8
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-1226394_422372.33333333333331509.0RepeatHEAT 9
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-1226434_461372.33333333333331509.0RepeatHEAT 10
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-1226475_508372.33333333333331509.0RepeatHEAT 11
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-1226516_549372.33333333333331509.0RepeatHEAT 12
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-1226557_595372.33333333333331509.0RepeatHEAT 13
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-1226603_654372.33333333333331509.0RepeatHEAT 14
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-1226665_696372.33333333333331509.0RepeatHEAT 15
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-1226704_737372.33333333333331509.0RepeatHEAT 16
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-1226745_790372.33333333333331509.0RepeatHEAT 17
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-1226798_831372.33333333333331509.0RepeatHEAT 18
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-1226840_871372.33333333333331509.0RepeatHEAT 19
HgeneTNPO2chr19:12822110chr19:12885711ENST00000425528-1226874_894372.33333333333331509.0RepeatHEAT 20
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-1226296_386372.33333333333331499.0RepeatHEAT 8
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-1226394_422372.33333333333331499.0RepeatHEAT 9
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-1226434_461372.33333333333331499.0RepeatHEAT 10
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-1226475_508372.33333333333331499.0RepeatHEAT 11
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-1226516_549372.33333333333331499.0RepeatHEAT 12
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-1226557_595372.33333333333331499.0RepeatHEAT 13
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-1226603_654372.33333333333331499.0RepeatHEAT 14
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-1226665_696372.33333333333331499.0RepeatHEAT 15
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-1226704_737372.33333333333331499.0RepeatHEAT 16
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-1226745_790372.33333333333331499.0RepeatHEAT 17
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-1226798_831372.33333333333331499.0RepeatHEAT 18
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-1226840_871372.33333333333331499.0RepeatHEAT 19
HgeneTNPO2chr19:12822110chr19:12885711ENST00000441499-1226874_894372.33333333333331499.0RepeatHEAT 20
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-1024296_386372.33333333333331150.0RepeatHEAT 8
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-1024394_422372.33333333333331150.0RepeatHEAT 9
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-1024434_461372.33333333333331150.0RepeatHEAT 10
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-1024475_508372.33333333333331150.0RepeatHEAT 11
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-1024516_549372.33333333333331150.0RepeatHEAT 12
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-1024557_595372.33333333333331150.0RepeatHEAT 13
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-1024603_654372.33333333333331150.0RepeatHEAT 14
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-1024665_696372.33333333333331150.0RepeatHEAT 15
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-1024704_737372.33333333333331150.0RepeatHEAT 16
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-1024745_790372.33333333333331150.0RepeatHEAT 17
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-1024798_831372.33333333333331150.0RepeatHEAT 18
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-1024840_871372.33333333333331150.0RepeatHEAT 19
HgeneTNPO2chr19:12822110chr19:12885711ENST00000450764-1024874_894372.33333333333331150.0RepeatHEAT 20
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-1225296_386372.3333333333333888.0RepeatHEAT 8
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-1225394_422372.3333333333333888.0RepeatHEAT 9
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-1225434_461372.3333333333333888.0RepeatHEAT 10
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-1225475_508372.3333333333333888.0RepeatHEAT 11
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-1225516_549372.3333333333333888.0RepeatHEAT 12
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-1225557_595372.3333333333333888.0RepeatHEAT 13
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-1225603_654372.3333333333333888.0RepeatHEAT 14
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-1225665_696372.3333333333333888.0RepeatHEAT 15
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-1225704_737372.3333333333333888.0RepeatHEAT 16
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-1225745_790372.3333333333333888.0RepeatHEAT 17
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-1225798_831372.3333333333333888.0RepeatHEAT 18
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-1225840_871372.3333333333333888.0RepeatHEAT 19
HgeneTNPO2chr19:12822110chr19:12885711ENST00000588216-1225874_894372.3333333333333888.0RepeatHEAT 20
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-1125296_386372.3333333333333901.6666666666666RepeatHEAT 8
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-1125394_422372.3333333333333901.6666666666666RepeatHEAT 9
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-1125434_461372.3333333333333901.6666666666666RepeatHEAT 10
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-1125475_508372.3333333333333901.6666666666666RepeatHEAT 11
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-1125516_549372.3333333333333901.6666666666666RepeatHEAT 12
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-1125557_595372.3333333333333901.6666666666666RepeatHEAT 13
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-1125603_654372.3333333333333901.6666666666666RepeatHEAT 14
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-1125665_696372.3333333333333901.6666666666666RepeatHEAT 15
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-1125704_737372.3333333333333901.6666666666666RepeatHEAT 16
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-1125745_790372.3333333333333901.6666666666666RepeatHEAT 17
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-1125798_831372.3333333333333901.6666666666666RepeatHEAT 18
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-1125840_871372.3333333333333901.6666666666666RepeatHEAT 19
HgeneTNPO2chr19:12822110chr19:12885711ENST00000592287-1125874_894372.3333333333333901.6666666666666RepeatHEAT 20
TgeneHOOK2chr19:12822110chr19:12885711ENST000002648270226_12215.0718.0DomainCalponin-homology (CH)
TgeneHOOK2chr19:12822110chr19:12885711ENST000003976680236_12215.0720.0DomainCalponin-homology (CH)
TgeneHOOK2chr19:12822110chr19:12885711ENST000002648270221_16115.0718.0RegionNote=Required for localization to the centrosome and induction of aggresome formation
TgeneHOOK2chr19:12822110chr19:12885711ENST000003976680231_16115.0720.0RegionNote=Required for localization to the centrosome and induction of aggresome formation


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Fusion Gene Sequence for TNPO2-HOOK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TNPO2-HOOK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TNPO2-HOOK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TNPO2-HOOK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTNPO2C0032460Polycystic Ovary Syndrome1CTD_human
HgeneTNPO2C1136382Sclerocystic Ovaries1CTD_human