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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:TNRC6A-PRKCB (FusionGDB2 ID:92218) |
Fusion Gene Summary for TNRC6A-PRKCB |
Fusion gene summary |
Fusion gene information | Fusion gene name: TNRC6A-PRKCB | Fusion gene ID: 92218 | Hgene | Tgene | Gene symbol | TNRC6A | PRKCB | Gene ID | 27327 | 5579 |
Gene name | trinucleotide repeat containing adaptor 6A | protein kinase C beta | |
Synonyms | CAGH26|FAME6|GW1|GW182|TNRC6 | PKC-beta|PKCB|PKCI(2)|PKCbeta|PRKCB1|PRKCB2 | |
Cytomap | 16p12.1 | 16p12.2-p12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | trinucleotide repeat-containing gene 6A proteinCAG repeat protein 26CTD-2540M10.1EDIEEMSY interactor proteinGW182 autoantigenglycine-tryptophan protein of 182 kDatrinucleotide repeat containing 6A | protein kinase C beta typePKC-Bprotein kinase C, beta 1 polypeptide | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000315183, ENST00000562829, ENST00000395799, ENST00000432286, | ENST00000321728, ENST00000303531, ENST00000482000, ENST00000498058, | |
Fusion gene scores | * DoF score | 10 X 10 X 6=600 | 20 X 15 X 13=3900 |
# samples | 12 | 25 | |
** MAII score | log2(12/600*10)=-2.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(25/3900*10)=-3.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TNRC6A [Title/Abstract] AND PRKCB [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | TNRC6A(24741621)-PRKCB(24192111), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TNRC6A | GO:0035278 | miRNA mediated inhibition of translation | 17671087 |
Tgene | PRKCB | GO:0010827 | regulation of glucose transmembrane transport | 25982116 |
Tgene | PRKCB | GO:0035408 | histone H3-T6 phosphorylation | 20228790 |
Fusion gene breakpoints across TNRC6A (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across PRKCB (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | GBM | TCGA-06-0882-01A | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
ChimerDB4 | GBM | TCGA-06-0882-01A | TNRC6A | chr16 | 24741621 | - | PRKCB | chr16 | 24192111 | + |
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Fusion Gene ORF analysis for TNRC6A-PRKCB |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000315183 | ENST00000321728 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
In-frame | ENST00000315183 | ENST00000303531 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
5CDS-intron | ENST00000315183 | ENST00000482000 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
5CDS-intron | ENST00000315183 | ENST00000498058 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
3UTR-3CDS | ENST00000562829 | ENST00000321728 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
3UTR-3CDS | ENST00000562829 | ENST00000303531 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
3UTR-intron | ENST00000562829 | ENST00000482000 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
3UTR-intron | ENST00000562829 | ENST00000498058 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
In-frame | ENST00000395799 | ENST00000321728 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
In-frame | ENST00000395799 | ENST00000303531 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
5CDS-intron | ENST00000395799 | ENST00000482000 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
5CDS-intron | ENST00000395799 | ENST00000498058 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
intron-3CDS | ENST00000432286 | ENST00000321728 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
intron-3CDS | ENST00000432286 | ENST00000303531 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
intron-intron | ENST00000432286 | ENST00000482000 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
intron-intron | ENST00000432286 | ENST00000498058 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000315183 | TNRC6A | chr16 | 24741621 | + | ENST00000321728 | PRKCB | chr16 | 24192111 | + | 1320 | 200 | 126 | 821 | 231 |
ENST00000315183 | TNRC6A | chr16 | 24741621 | + | ENST00000303531 | PRKCB | chr16 | 24192111 | + | 6623 | 200 | 126 | 827 | 233 |
ENST00000395799 | TNRC6A | chr16 | 24741621 | + | ENST00000321728 | PRKCB | chr16 | 24192111 | + | 1302 | 182 | 108 | 803 | 231 |
ENST00000395799 | TNRC6A | chr16 | 24741621 | + | ENST00000303531 | PRKCB | chr16 | 24192111 | + | 6605 | 182 | 108 | 809 | 233 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000315183 | ENST00000321728 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + | 0.000979594 | 0.99902046 |
ENST00000315183 | ENST00000303531 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + | 0.00120767 | 0.9987923 |
ENST00000395799 | ENST00000321728 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + | 0.001249072 | 0.9987509 |
ENST00000395799 | ENST00000303531 | TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192111 | + | 0.001227196 | 0.9987728 |
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Fusion Genomic Features for TNRC6A-PRKCB |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192110 | + | 6.38E-06 | 0.99999356 |
TNRC6A | chr16 | 24741621 | + | PRKCB | chr16 | 24192110 | + | 6.38E-06 | 0.99999356 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for TNRC6A-PRKCB |
Go to FGviewer for the breakpoints of chr16:24741621-chr16:24192111 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000303531 | 11 | 17 | 601_671 | 464.6666666666667 | 674.0 | Domain | AGC-kinase C-terminal | |
Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000321728 | 11 | 17 | 601_671 | 464.6666666666667 | 672.0 | Domain | AGC-kinase C-terminal | |
Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000498058 | 0 | 2 | 158_275 | 0 | 58.0 | Domain | C2 | |
Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000498058 | 0 | 2 | 342_600 | 0 | 58.0 | Domain | Protein kinase | |
Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000498058 | 0 | 2 | 601_671 | 0 | 58.0 | Domain | AGC-kinase C-terminal | |
Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000498058 | 0 | 2 | 348_356 | 0 | 58.0 | Nucleotide binding | ATP | |
Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000498058 | 0 | 2 | 101_151 | 0 | 58.0 | Zinc finger | Phorbol-ester/DAG-type 2 | |
Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000498058 | 0 | 2 | 36_86 | 0 | 58.0 | Zinc finger | Phorbol-ester/DAG-type 1 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000315183 | + | 2 | 24 | 7_54 | 17.666666666666668 | 1914.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000395799 | + | 2 | 25 | 7_54 | 17.666666666666668 | 1963.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000315183 | + | 2 | 24 | 192_365 | 17.666666666666668 | 1914.0 | Compositional bias | Note=Ser-rich |
Hgene | TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000315183 | + | 2 | 24 | 93_127 | 17.666666666666668 | 1914.0 | Compositional bias | Note=Gln-rich |
Hgene | TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000395799 | + | 2 | 25 | 192_365 | 17.666666666666668 | 1963.0 | Compositional bias | Note=Ser-rich |
Hgene | TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000395799 | + | 2 | 25 | 93_127 | 17.666666666666668 | 1963.0 | Compositional bias | Note=Gln-rich |
Hgene | TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000315183 | + | 2 | 24 | 1781_1853 | 17.666666666666668 | 1914.0 | Domain | Note=RRM |
Hgene | TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000395799 | + | 2 | 25 | 1781_1853 | 17.666666666666668 | 1963.0 | Domain | Note=RRM |
Hgene | TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000315183 | + | 2 | 24 | 1604_1622 | 17.666666666666668 | 1914.0 | Region | Note=PABPC1-interacting motif-2 (PAM2) |
Hgene | TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000395799 | + | 2 | 25 | 1604_1622 | 17.666666666666668 | 1963.0 | Region | Note=PABPC1-interacting motif-2 (PAM2) |
Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000303531 | 11 | 17 | 158_275 | 464.6666666666667 | 674.0 | Domain | C2 | |
Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000303531 | 11 | 17 | 342_600 | 464.6666666666667 | 674.0 | Domain | Protein kinase | |
Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000321728 | 11 | 17 | 158_275 | 464.6666666666667 | 672.0 | Domain | C2 | |
Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000321728 | 11 | 17 | 342_600 | 464.6666666666667 | 672.0 | Domain | Protein kinase | |
Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000303531 | 11 | 17 | 348_356 | 464.6666666666667 | 674.0 | Nucleotide binding | ATP | |
Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000321728 | 11 | 17 | 348_356 | 464.6666666666667 | 672.0 | Nucleotide binding | ATP | |
Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000303531 | 11 | 17 | 101_151 | 464.6666666666667 | 674.0 | Zinc finger | Phorbol-ester/DAG-type 2 | |
Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000303531 | 11 | 17 | 36_86 | 464.6666666666667 | 674.0 | Zinc finger | Phorbol-ester/DAG-type 1 | |
Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000321728 | 11 | 17 | 101_151 | 464.6666666666667 | 672.0 | Zinc finger | Phorbol-ester/DAG-type 2 | |
Tgene | PRKCB | chr16:24741621 | chr16:24192111 | ENST00000321728 | 11 | 17 | 36_86 | 464.6666666666667 | 672.0 | Zinc finger | Phorbol-ester/DAG-type 1 |
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Fusion Gene Sequence for TNRC6A-PRKCB |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000315183_ENST00000321728_TCGA-06-0882-01A_TNRC6A_chr16_24741621_+_PRKCB_chr16_24192111_length(transcript)=1320nt_BP=200nt GGCGGCGGCGGCGGCGGCGGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGG GCTTGAGGCTCGCGAGCCTCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGAGAATTGGAAGCTAAAGCTACCAAAGAC GTAGAAAGAAATCTTAGCAGTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAGGGACACATCAAGATTGCCGATTTTGGCATGTGT AAGGAAAACATCTGGGATGGGGTGACAACCAAGACATTCTGTGGCACTCCAGACTACATCGCCCCCGAGATAATTGCTTATCAGCCCTAT GGGAAGTCCGTGGATTGGTGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGGCAGGCACCCTTTGAAGGGGAGGATGAAGATGAA CTCTTCCAATCCATCATGGAACACAACGTAGCCTATCCCAAGTCTATGTCCAAGGAAGCTGTGGCCATCTGCAAAGGGCTGATGACCAAA CACCCAGGCAAACGTCTGGGTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGCATGCATTTTTCCGGTATATTGATTGGGAGAAACTT GAACGCAAAGAGATCCAGCCCCCTTATAAGCCAAAAGCTAGAGACAAGAGAGACACCTCCAACTTCGACAAAGAGTTCACCAGACAGCCT GTGGAACTGACCCCCACTGATAAACTCTTCATCATGAACTTGGACCAAAATGAATTTGCTGGCTTCTCTTATACTAACCCAGAGTTTGTC ATTAATGTGTAGGTGAATGCAAACTCCATCGTTGAGCCTGGGGTGTAAGACTTCAAGCCAAGCGTATGTATCAATTCTAGTCTTCCAGGA TTCACGGTGCACATGCTGGCATTCAACATGTGGAAAGCTTGTCTTAGAGGGCTTTTCTTTGTATGTGTAGCTTGCTAGTTTGTTTTCTAC ATTTGAAAATGTTTAGTTTAGAATAAGCGCATTATCCAATTATAGAGGTACAATTTTCCAAACTTCCAGAAACTCATCAAATGAACAGAC AATGTCAAAACTACTGTGTCTGATACCAAAATGCTTCAGTATTTGTAATTTTTCAAGTCAGAAGCTGATGTTCCTGGTAAAAGTTTTTAC AGTTATTCTATAATATCTTCTTTGAATGCTAAGCATGAGCGATATTTTTAAAAATTGTGAGTAAGCTTTGCAGTTACTGTGAACTATTGT >In-frame_ENST00000315183_ENST00000321728_TCGA-06-0882-01A_TNRC6A_chr16_24741621_+_PRKCB_chr16_24192111_length(amino acids)=231AA_start in transcript=126_stop in transcript=821 MLVHFTHMRELEAKATKDVERNLSSDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVL LYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK -------------------------------------------------------------- >In-frame_ENST00000315183_ENST00000303531_TCGA-06-0882-01A_TNRC6A_chr16_24741621_+_PRKCB_chr16_24192111_length(transcript)=6623nt_BP=200nt GGCGGCGGCGGCGGCGGCGGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGG GCTTGAGGCTCGCGAGCCTCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGAGAATTGGAAGCTAAAGCTACCAAAGAC GTAGAAAGAAATCTTAGCAGTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAGGGACACATCAAGATTGCCGATTTTGGCATGTGT AAGGAAAACATCTGGGATGGGGTGACAACCAAGACATTCTGTGGCACTCCAGACTACATCGCCCCCGAGATAATTGCTTATCAGCCCTAT GGGAAGTCCGTGGATTGGTGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGGCAGGCACCCTTTGAAGGGGAGGATGAAGATGAA CTCTTCCAATCCATCATGGAACACAACGTAGCCTATCCCAAGTCTATGTCCAAGGAAGCTGTGGCCATCTGCAAAGGGCTGATGACCAAA CACCCAGGCAAACGTCTGGGTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGCATGCATTTTTCCGGTATATTGATTGGGAGAAACTT GAACGCAAAGAGATCCAGCCCCCTTATAAGCCAAAAGCTTGTGGGCGAAATGCTGAAAACTTCGACCGATTTTTCACCCGCCATCCACCA GTCCTAACACCTCCCGACCAGGAAGTCATCAGGAATATTGACCAATCAGAATTCGAAGGATTTTCCTTTGTTAACTCTGAATTTTTAAAA CCCGAAGTCAAGAGCTAAGTAGATGTGTAGATCTCCGTCCTTCATTTCTGTCATTCAAGCTCAACGGCTATTGTGGTGACATTTTTATGT TTTTCATTGCCAAGTTGCATCCATGTTTGATTTTCTGATGAGACTAGAGTGACAGTGTTTCAGAACCCAAATGTCCTCAGGTAGTTTGGA GCATCTCTATGAGATGGGATTATGCAGATGGCCTATGGAAAATGCAGCTGCATAATTAACACATTATCAAAGTCCTCTTACAATTTATTT TCCGCAGCATGTCAGCTAAGTAGACCCAATGGGGAGAGAAAATGCCTGCTTTCTTTCCCTCTTTTTCTGCACTGCCATATTCACCCCCAA CCATCCAATCTGTGGATAATTGGATGTTAGCGGTACTCTTCCACTTCCGGGCCTGGAGCTTGGCTTGTATCCAAGTGTATGGTTGCTTTG CCTAAGAGGAATCCCTCTATTTCACCTGTTCTGGAGGCACCAGACCTTGAAAAGAACATGCTCAAAATAAAATGTTATCTGTTATTTTTG TAAACTCAAAGTTAAGATGATCAAAGTTCTAAAATTCCAAGAATGTGCTTTTAGACGGTCTCAATCTAAAAGCACTTCAAGGGGTCAAAG GGCAACCAGCTTGGGTGCTACCTCAGTGTTGTAGTTTCTGATACTTTATGTCTTTGCTCACCCTCATCCCCAAACTACTTGAAAAGGGCA TTTGGCACCACTCTCTGAAACAACACAGTCACTCTAGCAAGGCCCCCAAAGGGCCCTGGTTTTACATTACATTTCAAACTTTATTTGCTT TGGGGTTTTGTTTCTGTTGTTGTTCAAATGCAAAAAAAAGAAAAAAAAAGAAAAAAAAAGGTGACTCACATTGTTACACATGCTTTAAAA TATGTATTCAAATGTTATTAACCACAATGACGACCTGCTTTGATTTAACCAAGAAGACGGCTGCGGAGCCTAGCAGACTCAGGCCTGTGG GAATGGGATTTGTTACAAATCTAGGTTTGTTACTGGCTTCAGAAAGCTAATTAAGTGCTCTGAAAAAGACACCGTTTCTTGAAACAAAGA TGGTTGTATTCCTCACTTTGATGTTGTTTTGCAAGATGTTTGTGGAAATGTTCATTTGTATCTGGATCTCTGTTATGTGCCATTTTTCTT CTAGCATCGAGATACAATAAAAAAAAAAAAAAAGAAAAGAAGAAGAAATACTATTTCAAGGAAAACTGCTCTTTTTGAGAAACGTGGACC TAAACTACAAAGTGGGAACTGAGGAGGGAACTCAGGAGAAAGGAACTAACTGCGGAGCTTTAATCTTGGCCCCAGTGTTCAGCCACTCGG AGGGGCGGGGGCTGTGGCCCATTCAGGGGCTGCTGGTGGGCTGTAGTGGGGTGGGATGACCTGGCCAGAGCCAACGAGGATACTGGAGCC CAAAGTCAAGTTTAGAGACCAGCTGGGAACGTGAATGGGGCTCTTGATTTTCTTATCAAAATCACCACTCCTCCCAGCTTGGACTAAATA TTCTTTCTAGCAAGCAGCTTTGTGAGCTCCCTGAAGCCCAAGGAAACCCTTCGGTGGGAGAAATTTCATTTCTGTCTGAGAGGATTAAGG CAGCAGGTGACTCCCCCTCCTCGCCTGCCGTGTCCTGCTATTCTCAGGCAGCTCTAAGGAGAATTCTTATCACAGTTCAAGTGATTTCCA GAAGTTCCAGGGCTTCTGAGAGACCATCAAGGGAACTTTAACAACTTGACAAATGTCCTTGAAGTAAGATGCCTCATCTTTAGGGAAAAA TGGGGTTTGGATTTCTGCTTAGGCAAAGTCTCCTGCAGTTCATCCTTCTCTGTCCTCTTCTTGCTTCAGGCTTGGGGACCGTCCCTGCTG TCCCCACTGTGGTGGCAATCAGGACCTAAGGTGAAGCAAACTTGAAGTTCTATCTGACAAGTTTAGGCAGTAAGAGAAGGAGGGAAATCG GAGCAAAGCTCCCTCACTTTATTGTTGAGAAACTGGCATCTGGAAAGAGGAAGGAATTTGCCCAAAGTCAGTCAGCTGGGATAAAAACCT GGGTGTCCTGTCCAGAAAGTGCAGGGTGCTTTCTGCTCTGTAGCAAGGCAGCAGACATCTCTGAGCCAGGCCCACCAACAGGCCCTTATC TGGTGGTTGGATCATGATCCCATTTTGCTTGGACATGCTCTCAGGAAGATAAAAACCATGGAGAAACACTAGGCCATTGACAAATGATCT GAGACAACTTTAGAAAACAATGTAGGATGAATGGAAAGAGAAAGAAAGGAAAGAAAGAAGAAAAAGAAAGAAGGAAAGAAAGAAAGAGAA AGGAAGGAAGGAAAGAAGGAAGGAAAAGAAGGAAGGAAGGAAGGAATATAGTGTTATAAATACTGCACTCAACATTTTCCAAATTCTTGC CATTATTTTTCAAAAGTTTAATAGTTTGCAGAAATAGATACTCAAGCCAAAGTCTGTTTTAGAGAAACTTTCCATGGAAAGTCAGAATTT CTACCACTTCCTTTTCTATCCACATTTCCAGTGCAGAAGAAACTGAGAAACAGAGCTTTTTGAAGAGAGGACAGGGCCATAGCAACAAGG ACCTTCTTGGGGGATTAATGGGAGGTCAGTAGAATTAATAACCCTCCTTGGATGAGTGCTACTGTTTTCACATGGCTTCAGATGCTATCA ACCTCAAAGAAATGATCTCAACAGAGAAGCTTATTCTCTCCCAACTTCTACGGTAAAATCCAGGAGTATTTTCTCTGGGGATCTGCCCAC AGGACAAAGTCCATAAAAGCAAGTCCTGTCTGGACCATGTGGTTATCTGAAGCATTAGCCATCACCAGCACAACAAACGGGGCAGGGCTT TCCAAGGTGGGGCTGGTCAGAAGGGAATCTTTGATAAGAGGCCCACAGGCAGGGAAAGCGAAATAGGGTTGATGAGACCAGGGGAGACCT AAAAAAAAGGCAGCTTTGTGTCTTCTAGCTCCAAATATACCTGCCTTTTAGCTCACACACTGTCCTGGAGTTCTCAGACCTTTAGGGGCC CTAACACAGTTCAGTTCATACAGGGGTTCAAAAGGGACAGTGGCCCATTTGGGAGACCTTTAGGATCAATGGGAATCAATTCCATTGTTT TGCCTCAGAGTAAAGTTTCTGGCTCGGGGACAATTATAAGTTGCAAAAAGGATAGAGGCATATCCCAAGTCTTCCTTCATTCCACAAATA ATTACAAACAACCTACTGTGTGCCAGGCACTATTCTTAGCACTGGAAATACACTAGTGAAGAAGCAGATGAGGACCCTGTTTATTGTTTC TCTCCAAGAAATTCTCCAAGAATATTGTTTCTTGGAGAGAAATAATAAATAAACAAGACAATTTCTGAAAGCAATAAGTGCAATCAAGAT AATTAAAGGATGCTAAAGTGTGACTTGTGGGGATTGGGAGAGAGATGCACAGACAATATTAAAGAGGAGGCATTCGAGCTTTGTTGTGAA CACCGGAAGTAACATGCCGAGCGCCTGGGGGATGGAAACTCCTATAGCACCCCACAGGCTAACAGCAAGCAGGACAAGACAAAAAGGGCA GGTGGGACATGGTAGAGATGGACCCTACCCAGGAAACAGCTCCATCAGCATCTTAGCCTGCCCCACTCTAGCCACACATACCCACGTGTG CTCCTGAGTTCAGTGTGCCCACCTCACTCCCACACCCTCACATAGACTTGGCAAGAGTAAGGAGGGAACTCCATAGAGACATTTTACCTA TCTCAGGGGAGCAGCCACAAAGAAGCAAGTCTTGTAAAAGGTCTTTTGCAAAGGAGAGTGAACCCAGCAATGAGAGATCCTTAACAGCTA GTGCCCATTAGGGGGCTAAACCTAAAGCCTGGGTGGTGATGGCTCAAACGCTAATGAGTCAGTGAATCCTTACCGACCCCCTGGCCTTTA TAATCTGAGGCAACTTTGGCTGCAGCCCGGGAATGTGCAGGGCACTAGGGAATACAAGGCCTTCTTCCCTGGTTGTCTTGTAATAAAACA GCCATGGGGTTGTCCCTCCAGTCCGAGAGACTGTGATGAGGCCTACATAGCAGCGATGTGGTCAGGTAAAAATCAGGAACCCACTGAAAT CTTGGGCAAGCCACCCTGCCTGCTTGTGCCTCGGTTCTCTCATATGTCATATATAGGAGGTGAGGACTCCAGCTCCACCTGCCCCAGGTG GGTGTGGTGATGATGAGGAAAGACAAGAGGCTTGCAAGGACCCTGAAGAGGTCGGAGCATCATACAGATTCCTTTATTAGCCCACATTCT GATGTTCCCTGGTGAGACTTGCCCCAAGCAATTGCTAGTAAATGGGGGTTAATTTCTTCTCCACCTCCCTACTGAACAAAAAAAGAAATG CCAGACTTACTAGGAGAATCGAGTTGCTTTGAGTTTCTTTTGTTTTGTTTTGTTTTGTTTTGTTTTAAGGCTCCCCTTACACACCCTCCT TTAAGCTTTGGGTTTTCTCTCTTATAGTTTGTTGACACATGCTAAAAATGTCTTTGGAGAGAACTTCTGCCTGATAAACACCCAATTCTA GACTGTGGGTGGATTTTCGAGCTGACGGTGGTCAATTCCTTTCATTAAGCAGTGATCTGATTTCTCCACATGGCCATTCTGCCTTCTTGG GGGCAGAGTAGATGGGCAGCAGTTCACCTTTTCAGAGAAAGAGGTCTTCTAGCCACCTGGGCTGCTACTGAATGGTTTTCTCCAGGACGC TCTACCTAATGATTATTTCTATAACATTAAGCATGGTAATAAGTAGCTTCCAATTCAATTCATCCTAAAGCCAAAGAAAATACAGCAACA CACACACACACACACACACACACACACACACACACACACACACACCACTTTATGGCAATTCTTAACTGACATTCAATGACTTACTTCTTT TCTTAGAAAATTTCCACCACATTTCTATCCCCAAGCCAACATACAATGTGAAATGAAAGCCAGTGCGTGGAGTGCAGCTGCTAAAAATTT TCAGCACAGGGCTCTTTCTGACTCTGCTCATGAGATGGTATCAGCCACCCAATGACTGGCGTATCTTGGTCCTGTGTCTTTCTTCTTACG CTGTGTTAATGTGTTTACTTTCCATTTGGCAGAGAGACAAGAGAGACACCTCCAACTTCGACAAAGAGTTCACCAGACAGCCTGTGGAAC TGACCCCCACTGATAAACTCTTCATCATGAACTTGGACCAAAATGAATTTGCTGGCTTCTCTTATACTAACCCAGAGTTTGTCATTAATG TGTAGGTGAATGCAAACTCCATCGTTGAGCCTGGGGTGTAAGACTTCAAGCCAAGCGTATGTATCAATTCTAGTCTTCCAGGATTCACGG TGCACATGCTGGCATTCAACATGTGGAAAGCTTGTCTTAGAGGGCTTTTCTTTGTATGTGTAGCTTGCTAGTTTGTTTTCTACATTTGAA AATGTTTAGTTTAGAATAAGCGCATTATCCAATTATAGAGGTACAATTTTCCAAACTTCCAGAAACTCATCAAATGAACAGACAATGTCA AAACTACTGTGTCTGATACCAAAATGCTTCAGTATTTGTAATTTTTCAAGTCAGAAGCTGATGTTCCTGGTAAAAGTTTTTACAGTTATT CTATAATATCTTCTTTGAATGCTAAGCATGAGCGATATTTTTAAAAATTGTGAGTAAGCTTTGCAGTTACTGTGAACTATTGTCTCTTGG >In-frame_ENST00000315183_ENST00000303531_TCGA-06-0882-01A_TNRC6A_chr16_24741621_+_PRKCB_chr16_24192111_length(amino acids)=233AA_start in transcript=126_stop in transcript=827 MLVHFTHMRELEAKATKDVERNLSSDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVL LYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK -------------------------------------------------------------- >In-frame_ENST00000395799_ENST00000321728_TCGA-06-0882-01A_TNRC6A_chr16_24741621_+_PRKCB_chr16_24192111_length(transcript)=1302nt_BP=182nt GGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGGGCTTGAGGCTCGCGAGCC TCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGC AGTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAGGGACACATCAAGATTGCCGATTTTGGCATGTGTAAGGAAAACATCTGGGAT GGGGTGACAACCAAGACATTCTGTGGCACTCCAGACTACATCGCCCCCGAGATAATTGCTTATCAGCCCTATGGGAAGTCCGTGGATTGG TGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGGCAGGCACCCTTTGAAGGGGAGGATGAAGATGAACTCTTCCAATCCATCATG GAACACAACGTAGCCTATCCCAAGTCTATGTCCAAGGAAGCTGTGGCCATCTGCAAAGGGCTGATGACCAAACACCCAGGCAAACGTCTG GGTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGCATGCATTTTTCCGGTATATTGATTGGGAGAAACTTGAACGCAAAGAGATCCAG CCCCCTTATAAGCCAAAAGCTAGAGACAAGAGAGACACCTCCAACTTCGACAAAGAGTTCACCAGACAGCCTGTGGAACTGACCCCCACT GATAAACTCTTCATCATGAACTTGGACCAAAATGAATTTGCTGGCTTCTCTTATACTAACCCAGAGTTTGTCATTAATGTGTAGGTGAAT GCAAACTCCATCGTTGAGCCTGGGGTGTAAGACTTCAAGCCAAGCGTATGTATCAATTCTAGTCTTCCAGGATTCACGGTGCACATGCTG GCATTCAACATGTGGAAAGCTTGTCTTAGAGGGCTTTTCTTTGTATGTGTAGCTTGCTAGTTTGTTTTCTACATTTGAAAATGTTTAGTT TAGAATAAGCGCATTATCCAATTATAGAGGTACAATTTTCCAAACTTCCAGAAACTCATCAAATGAACAGACAATGTCAAAACTACTGTG TCTGATACCAAAATGCTTCAGTATTTGTAATTTTTCAAGTCAGAAGCTGATGTTCCTGGTAAAAGTTTTTACAGTTATTCTATAATATCT TCTTTGAATGCTAAGCATGAGCGATATTTTTAAAAATTGTGAGTAAGCTTTGCAGTTACTGTGAACTATTGTCTCTTGGAGGAAGTTTTT >In-frame_ENST00000395799_ENST00000321728_TCGA-06-0882-01A_TNRC6A_chr16_24741621_+_PRKCB_chr16_24192111_length(amino acids)=231AA_start in transcript=108_stop in transcript=803 MLVHFTHMRELEAKATKDVERNLSSDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVL LYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK -------------------------------------------------------------- >In-frame_ENST00000395799_ENST00000303531_TCGA-06-0882-01A_TNRC6A_chr16_24741621_+_PRKCB_chr16_24192111_length(transcript)=6605nt_BP=182nt GGCGGCAGCGGGTCGGTGTAGAAAATGGCGCTGGTGCAGCGGCTCGGGCCTCTCCCCGCGGCGCTGCGGAGGGCTTGAGGCTCGCGAGCC TCCTTCGCCGCGCCCCACTTGCTCGTGCACTTTACACACATGAGAGAATTGGAAGCTAAAGCTACCAAAGACGTAGAAAGAAATCTTAGC AGTGACCTAAAACTTGACAACGTGATGCTCGATTCTGAGGGACACATCAAGATTGCCGATTTTGGCATGTGTAAGGAAAACATCTGGGAT GGGGTGACAACCAAGACATTCTGTGGCACTCCAGACTACATCGCCCCCGAGATAATTGCTTATCAGCCCTATGGGAAGTCCGTGGATTGG TGGGCATTTGGAGTCCTGCTGTATGAAATGTTGGCTGGGCAGGCACCCTTTGAAGGGGAGGATGAAGATGAACTCTTCCAATCCATCATG GAACACAACGTAGCCTATCCCAAGTCTATGTCCAAGGAAGCTGTGGCCATCTGCAAAGGGCTGATGACCAAACACCCAGGCAAACGTCTG GGTTGTGGACCTGAAGGCGAACGTGATATCAAAGAGCATGCATTTTTCCGGTATATTGATTGGGAGAAACTTGAACGCAAAGAGATCCAG CCCCCTTATAAGCCAAAAGCTTGTGGGCGAAATGCTGAAAACTTCGACCGATTTTTCACCCGCCATCCACCAGTCCTAACACCTCCCGAC CAGGAAGTCATCAGGAATATTGACCAATCAGAATTCGAAGGATTTTCCTTTGTTAACTCTGAATTTTTAAAACCCGAAGTCAAGAGCTAA GTAGATGTGTAGATCTCCGTCCTTCATTTCTGTCATTCAAGCTCAACGGCTATTGTGGTGACATTTTTATGTTTTTCATTGCCAAGTTGC ATCCATGTTTGATTTTCTGATGAGACTAGAGTGACAGTGTTTCAGAACCCAAATGTCCTCAGGTAGTTTGGAGCATCTCTATGAGATGGG ATTATGCAGATGGCCTATGGAAAATGCAGCTGCATAATTAACACATTATCAAAGTCCTCTTACAATTTATTTTCCGCAGCATGTCAGCTA AGTAGACCCAATGGGGAGAGAAAATGCCTGCTTTCTTTCCCTCTTTTTCTGCACTGCCATATTCACCCCCAACCATCCAATCTGTGGATA ATTGGATGTTAGCGGTACTCTTCCACTTCCGGGCCTGGAGCTTGGCTTGTATCCAAGTGTATGGTTGCTTTGCCTAAGAGGAATCCCTCT ATTTCACCTGTTCTGGAGGCACCAGACCTTGAAAAGAACATGCTCAAAATAAAATGTTATCTGTTATTTTTGTAAACTCAAAGTTAAGAT GATCAAAGTTCTAAAATTCCAAGAATGTGCTTTTAGACGGTCTCAATCTAAAAGCACTTCAAGGGGTCAAAGGGCAACCAGCTTGGGTGC TACCTCAGTGTTGTAGTTTCTGATACTTTATGTCTTTGCTCACCCTCATCCCCAAACTACTTGAAAAGGGCATTTGGCACCACTCTCTGA AACAACACAGTCACTCTAGCAAGGCCCCCAAAGGGCCCTGGTTTTACATTACATTTCAAACTTTATTTGCTTTGGGGTTTTGTTTCTGTT GTTGTTCAAATGCAAAAAAAAGAAAAAAAAAGAAAAAAAAAGGTGACTCACATTGTTACACATGCTTTAAAATATGTATTCAAATGTTAT TAACCACAATGACGACCTGCTTTGATTTAACCAAGAAGACGGCTGCGGAGCCTAGCAGACTCAGGCCTGTGGGAATGGGATTTGTTACAA ATCTAGGTTTGTTACTGGCTTCAGAAAGCTAATTAAGTGCTCTGAAAAAGACACCGTTTCTTGAAACAAAGATGGTTGTATTCCTCACTT TGATGTTGTTTTGCAAGATGTTTGTGGAAATGTTCATTTGTATCTGGATCTCTGTTATGTGCCATTTTTCTTCTAGCATCGAGATACAAT AAAAAAAAAAAAAAAGAAAAGAAGAAGAAATACTATTTCAAGGAAAACTGCTCTTTTTGAGAAACGTGGACCTAAACTACAAAGTGGGAA CTGAGGAGGGAACTCAGGAGAAAGGAACTAACTGCGGAGCTTTAATCTTGGCCCCAGTGTTCAGCCACTCGGAGGGGCGGGGGCTGTGGC CCATTCAGGGGCTGCTGGTGGGCTGTAGTGGGGTGGGATGACCTGGCCAGAGCCAACGAGGATACTGGAGCCCAAAGTCAAGTTTAGAGA CCAGCTGGGAACGTGAATGGGGCTCTTGATTTTCTTATCAAAATCACCACTCCTCCCAGCTTGGACTAAATATTCTTTCTAGCAAGCAGC TTTGTGAGCTCCCTGAAGCCCAAGGAAACCCTTCGGTGGGAGAAATTTCATTTCTGTCTGAGAGGATTAAGGCAGCAGGTGACTCCCCCT CCTCGCCTGCCGTGTCCTGCTATTCTCAGGCAGCTCTAAGGAGAATTCTTATCACAGTTCAAGTGATTTCCAGAAGTTCCAGGGCTTCTG AGAGACCATCAAGGGAACTTTAACAACTTGACAAATGTCCTTGAAGTAAGATGCCTCATCTTTAGGGAAAAATGGGGTTTGGATTTCTGC TTAGGCAAAGTCTCCTGCAGTTCATCCTTCTCTGTCCTCTTCTTGCTTCAGGCTTGGGGACCGTCCCTGCTGTCCCCACTGTGGTGGCAA TCAGGACCTAAGGTGAAGCAAACTTGAAGTTCTATCTGACAAGTTTAGGCAGTAAGAGAAGGAGGGAAATCGGAGCAAAGCTCCCTCACT TTATTGTTGAGAAACTGGCATCTGGAAAGAGGAAGGAATTTGCCCAAAGTCAGTCAGCTGGGATAAAAACCTGGGTGTCCTGTCCAGAAA GTGCAGGGTGCTTTCTGCTCTGTAGCAAGGCAGCAGACATCTCTGAGCCAGGCCCACCAACAGGCCCTTATCTGGTGGTTGGATCATGAT CCCATTTTGCTTGGACATGCTCTCAGGAAGATAAAAACCATGGAGAAACACTAGGCCATTGACAAATGATCTGAGACAACTTTAGAAAAC AATGTAGGATGAATGGAAAGAGAAAGAAAGGAAAGAAAGAAGAAAAAGAAAGAAGGAAAGAAAGAAAGAGAAAGGAAGGAAGGAAAGAAG GAAGGAAAAGAAGGAAGGAAGGAAGGAATATAGTGTTATAAATACTGCACTCAACATTTTCCAAATTCTTGCCATTATTTTTCAAAAGTT TAATAGTTTGCAGAAATAGATACTCAAGCCAAAGTCTGTTTTAGAGAAACTTTCCATGGAAAGTCAGAATTTCTACCACTTCCTTTTCTA TCCACATTTCCAGTGCAGAAGAAACTGAGAAACAGAGCTTTTTGAAGAGAGGACAGGGCCATAGCAACAAGGACCTTCTTGGGGGATTAA TGGGAGGTCAGTAGAATTAATAACCCTCCTTGGATGAGTGCTACTGTTTTCACATGGCTTCAGATGCTATCAACCTCAAAGAAATGATCT CAACAGAGAAGCTTATTCTCTCCCAACTTCTACGGTAAAATCCAGGAGTATTTTCTCTGGGGATCTGCCCACAGGACAAAGTCCATAAAA GCAAGTCCTGTCTGGACCATGTGGTTATCTGAAGCATTAGCCATCACCAGCACAACAAACGGGGCAGGGCTTTCCAAGGTGGGGCTGGTC AGAAGGGAATCTTTGATAAGAGGCCCACAGGCAGGGAAAGCGAAATAGGGTTGATGAGACCAGGGGAGACCTAAAAAAAAGGCAGCTTTG TGTCTTCTAGCTCCAAATATACCTGCCTTTTAGCTCACACACTGTCCTGGAGTTCTCAGACCTTTAGGGGCCCTAACACAGTTCAGTTCA TACAGGGGTTCAAAAGGGACAGTGGCCCATTTGGGAGACCTTTAGGATCAATGGGAATCAATTCCATTGTTTTGCCTCAGAGTAAAGTTT CTGGCTCGGGGACAATTATAAGTTGCAAAAAGGATAGAGGCATATCCCAAGTCTTCCTTCATTCCACAAATAATTACAAACAACCTACTG TGTGCCAGGCACTATTCTTAGCACTGGAAATACACTAGTGAAGAAGCAGATGAGGACCCTGTTTATTGTTTCTCTCCAAGAAATTCTCCA AGAATATTGTTTCTTGGAGAGAAATAATAAATAAACAAGACAATTTCTGAAAGCAATAAGTGCAATCAAGATAATTAAAGGATGCTAAAG TGTGACTTGTGGGGATTGGGAGAGAGATGCACAGACAATATTAAAGAGGAGGCATTCGAGCTTTGTTGTGAACACCGGAAGTAACATGCC GAGCGCCTGGGGGATGGAAACTCCTATAGCACCCCACAGGCTAACAGCAAGCAGGACAAGACAAAAAGGGCAGGTGGGACATGGTAGAGA TGGACCCTACCCAGGAAACAGCTCCATCAGCATCTTAGCCTGCCCCACTCTAGCCACACATACCCACGTGTGCTCCTGAGTTCAGTGTGC CCACCTCACTCCCACACCCTCACATAGACTTGGCAAGAGTAAGGAGGGAACTCCATAGAGACATTTTACCTATCTCAGGGGAGCAGCCAC AAAGAAGCAAGTCTTGTAAAAGGTCTTTTGCAAAGGAGAGTGAACCCAGCAATGAGAGATCCTTAACAGCTAGTGCCCATTAGGGGGCTA AACCTAAAGCCTGGGTGGTGATGGCTCAAACGCTAATGAGTCAGTGAATCCTTACCGACCCCCTGGCCTTTATAATCTGAGGCAACTTTG GCTGCAGCCCGGGAATGTGCAGGGCACTAGGGAATACAAGGCCTTCTTCCCTGGTTGTCTTGTAATAAAACAGCCATGGGGTTGTCCCTC CAGTCCGAGAGACTGTGATGAGGCCTACATAGCAGCGATGTGGTCAGGTAAAAATCAGGAACCCACTGAAATCTTGGGCAAGCCACCCTG CCTGCTTGTGCCTCGGTTCTCTCATATGTCATATATAGGAGGTGAGGACTCCAGCTCCACCTGCCCCAGGTGGGTGTGGTGATGATGAGG AAAGACAAGAGGCTTGCAAGGACCCTGAAGAGGTCGGAGCATCATACAGATTCCTTTATTAGCCCACATTCTGATGTTCCCTGGTGAGAC TTGCCCCAAGCAATTGCTAGTAAATGGGGGTTAATTTCTTCTCCACCTCCCTACTGAACAAAAAAAGAAATGCCAGACTTACTAGGAGAA TCGAGTTGCTTTGAGTTTCTTTTGTTTTGTTTTGTTTTGTTTTGTTTTAAGGCTCCCCTTACACACCCTCCTTTAAGCTTTGGGTTTTCT CTCTTATAGTTTGTTGACACATGCTAAAAATGTCTTTGGAGAGAACTTCTGCCTGATAAACACCCAATTCTAGACTGTGGGTGGATTTTC GAGCTGACGGTGGTCAATTCCTTTCATTAAGCAGTGATCTGATTTCTCCACATGGCCATTCTGCCTTCTTGGGGGCAGAGTAGATGGGCA GCAGTTCACCTTTTCAGAGAAAGAGGTCTTCTAGCCACCTGGGCTGCTACTGAATGGTTTTCTCCAGGACGCTCTACCTAATGATTATTT CTATAACATTAAGCATGGTAATAAGTAGCTTCCAATTCAATTCATCCTAAAGCCAAAGAAAATACAGCAACACACACACACACACACACA CACACACACACACACACACACACACACCACTTTATGGCAATTCTTAACTGACATTCAATGACTTACTTCTTTTCTTAGAAAATTTCCACC ACATTTCTATCCCCAAGCCAACATACAATGTGAAATGAAAGCCAGTGCGTGGAGTGCAGCTGCTAAAAATTTTCAGCACAGGGCTCTTTC TGACTCTGCTCATGAGATGGTATCAGCCACCCAATGACTGGCGTATCTTGGTCCTGTGTCTTTCTTCTTACGCTGTGTTAATGTGTTTAC TTTCCATTTGGCAGAGAGACAAGAGAGACACCTCCAACTTCGACAAAGAGTTCACCAGACAGCCTGTGGAACTGACCCCCACTGATAAAC TCTTCATCATGAACTTGGACCAAAATGAATTTGCTGGCTTCTCTTATACTAACCCAGAGTTTGTCATTAATGTGTAGGTGAATGCAAACT CCATCGTTGAGCCTGGGGTGTAAGACTTCAAGCCAAGCGTATGTATCAATTCTAGTCTTCCAGGATTCACGGTGCACATGCTGGCATTCA ACATGTGGAAAGCTTGTCTTAGAGGGCTTTTCTTTGTATGTGTAGCTTGCTAGTTTGTTTTCTACATTTGAAAATGTTTAGTTTAGAATA AGCGCATTATCCAATTATAGAGGTACAATTTTCCAAACTTCCAGAAACTCATCAAATGAACAGACAATGTCAAAACTACTGTGTCTGATA CCAAAATGCTTCAGTATTTGTAATTTTTCAAGTCAGAAGCTGATGTTCCTGGTAAAAGTTTTTACAGTTATTCTATAATATCTTCTTTGA ATGCTAAGCATGAGCGATATTTTTAAAAATTGTGAGTAAGCTTTGCAGTTACTGTGAACTATTGTCTCTTGGAGGAAGTTTTTTGTTTAA >In-frame_ENST00000395799_ENST00000303531_TCGA-06-0882-01A_TNRC6A_chr16_24741621_+_PRKCB_chr16_24192111_length(amino acids)=233AA_start in transcript=108_stop in transcript=809 MLVHFTHMRELEAKATKDVERNLSSDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVL LYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for TNRC6A-PRKCB |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000315183 | + | 2 | 24 | 1_932 | 17.666666666666668 | 1914.0 | argonaute family proteins |
Hgene | TNRC6A | chr16:24741621 | chr16:24192111 | ENST00000395799 | + | 2 | 25 | 1_932 | 17.666666666666668 | 1963.0 | argonaute family proteins |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for TNRC6A-PRKCB |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for TNRC6A-PRKCB |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TNRC6A | C0014550 | Myoclonic Epilepsy | 1 | CTD_human |
Hgene | TNRC6A | C0338478 | Idiopathic Myoclonic Epilepsy | 1 | CTD_human |
Hgene | TNRC6A | C0338479 | Symptomatic Myoclonic Epilepsy | 1 | CTD_human |
Hgene | TNRC6A | C0393695 | Early Childhood Epilepsy, Myoclonic | 1 | CTD_human |
Hgene | TNRC6A | C0393702 | Myoclonic Astatic Epilepsy | 1 | CTD_human |
Hgene | TNRC6A | C0393703 | Myoclonic Absence Epilepsy | 1 | CTD_human |
Hgene | TNRC6A | C0438414 | Myoclonic Encephalopathy | 1 | CTD_human |
Hgene | TNRC6A | C0751120 | Benign Infantile Myoclonic Epilepsy | 1 | CTD_human |
Hgene | TNRC6A | C0751122 | Infantile Severe Myoclonic Epilepsy | 1 | CTD_human |
Hgene | TNRC6A | C0917800 | Epilepsy, Myoclonic, Infantile | 1 | CTD_human |
Tgene | PRKCB | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | PRKCB | C0009402 | Colorectal Carcinoma | 1 | CTD_human |
Tgene | PRKCB | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Tgene | PRKCB | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
Tgene | PRKCB | C0018800 | Cardiomegaly | 1 | CTD_human |
Tgene | PRKCB | C0020456 | Hyperglycemia | 1 | CTD_human |
Tgene | PRKCB | C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | CTD_human |
Tgene | PRKCB | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | PRKCB | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
Tgene | PRKCB | C0025281 | Meniere Disease | 1 | GENOMICS_ENGLAND |
Tgene | PRKCB | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Tgene | PRKCB | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | PRKCB | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Tgene | PRKCB | C1383860 | Cardiac Hypertrophy | 1 | CTD_human |
Tgene | PRKCB | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
Tgene | PRKCB | C1855520 | Hyperglycemia, Postprandial | 1 | CTD_human |