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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TNS3-MAP3K3 (FusionGDB2 ID:92302)

Fusion Gene Summary for TNS3-MAP3K3

check button Fusion gene summary
Fusion gene informationFusion gene name: TNS3-MAP3K3
Fusion gene ID: 92302
HgeneTgene
Gene symbol

TNS3

MAP3K3

Gene ID

64759

4215

Gene nametensin 3mitogen-activated protein kinase kinase kinase 3
SynonymsTEM6|TENS1MAPKKK3|MEKK3
Cytomap

7p12.3

17q23.3

Type of geneprotein-codingprotein-coding
Descriptiontensin-3tensin-like SH2 domain containing 1tensin-like SH2 domain-containing protein 1thyroid specific PTB domain proteintumor endothelial marker 6mitogen-activated protein kinase kinase kinase 3MAP/ERK kinase kinase 3MAPK/ERK kinase kinase 3MEK kinase 3MEKK 3
Modification date2020032720200313
UniProtAcc.

Q99759

Ensembl transtripts involved in fusion geneENST00000311160, ENST00000355730, 
ENST00000398879, ENST00000442536, 
ENST00000458317, ENST00000474346, 
ENST00000579585, ENST00000584573, 
ENST00000361733, ENST00000361357, 
ENST00000577395, ENST00000577784, 
Fusion gene scores* DoF score21 X 21 X 13=57338 X 11 X 4=352
# samples 2811
** MAII scorelog2(28/5733*10)=-4.35579154675365
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/352*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TNS3 [Title/Abstract] AND MAP3K3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAP3K3(61700123)-TNS3(47344602), # samples:1
TNS3(47384353)-MAP3K3(61710040), # samples:1
Anticipated loss of major functional domain due to fusion event.TNS3-MAP3K3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TNS3-MAP3K3 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
TNS3-MAP3K3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAP3K3

GO:0035556

intracellular signal transduction

15001576

TgeneMAP3K3

GO:0046777

protein autophosphorylation

15001576


check buttonFusion gene breakpoints across TNS3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MAP3K3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AKP189193TNS3chr7

47384353

-MAP3K3chr17

61710040

+


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Fusion Gene ORF analysis for TNS3-MAP3K3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000311160ENST00000579585TNS3chr7

47384353

-MAP3K3chr17

61710040

+
Frame-shiftENST00000311160ENST00000584573TNS3chr7

47384353

-MAP3K3chr17

61710040

+
Frame-shiftENST00000311160ENST00000361733TNS3chr7

47384353

-MAP3K3chr17

61710040

+
Frame-shiftENST00000311160ENST00000361357TNS3chr7

47384353

-MAP3K3chr17

61710040

+
Frame-shiftENST00000311160ENST00000577395TNS3chr7

47384353

-MAP3K3chr17

61710040

+
5CDS-intronENST00000311160ENST00000577784TNS3chr7

47384353

-MAP3K3chr17

61710040

+
Frame-shiftENST00000355730ENST00000579585TNS3chr7

47384353

-MAP3K3chr17

61710040

+
Frame-shiftENST00000355730ENST00000584573TNS3chr7

47384353

-MAP3K3chr17

61710040

+
Frame-shiftENST00000355730ENST00000361733TNS3chr7

47384353

-MAP3K3chr17

61710040

+
Frame-shiftENST00000355730ENST00000361357TNS3chr7

47384353

-MAP3K3chr17

61710040

+
Frame-shiftENST00000355730ENST00000577395TNS3chr7

47384353

-MAP3K3chr17

61710040

+
5CDS-intronENST00000355730ENST00000577784TNS3chr7

47384353

-MAP3K3chr17

61710040

+
Frame-shiftENST00000398879ENST00000579585TNS3chr7

47384353

-MAP3K3chr17

61710040

+
Frame-shiftENST00000398879ENST00000584573TNS3chr7

47384353

-MAP3K3chr17

61710040

+
Frame-shiftENST00000398879ENST00000361733TNS3chr7

47384353

-MAP3K3chr17

61710040

+
Frame-shiftENST00000398879ENST00000361357TNS3chr7

47384353

-MAP3K3chr17

61710040

+
Frame-shiftENST00000398879ENST00000577395TNS3chr7

47384353

-MAP3K3chr17

61710040

+
5CDS-intronENST00000398879ENST00000577784TNS3chr7

47384353

-MAP3K3chr17

61710040

+
intron-3CDSENST00000442536ENST00000579585TNS3chr7

47384353

-MAP3K3chr17

61710040

+
intron-3CDSENST00000442536ENST00000584573TNS3chr7

47384353

-MAP3K3chr17

61710040

+
intron-3CDSENST00000442536ENST00000361733TNS3chr7

47384353

-MAP3K3chr17

61710040

+
intron-3CDSENST00000442536ENST00000361357TNS3chr7

47384353

-MAP3K3chr17

61710040

+
intron-3CDSENST00000442536ENST00000577395TNS3chr7

47384353

-MAP3K3chr17

61710040

+
intron-intronENST00000442536ENST00000577784TNS3chr7

47384353

-MAP3K3chr17

61710040

+
intron-3CDSENST00000458317ENST00000579585TNS3chr7

47384353

-MAP3K3chr17

61710040

+
intron-3CDSENST00000458317ENST00000584573TNS3chr7

47384353

-MAP3K3chr17

61710040

+
intron-3CDSENST00000458317ENST00000361733TNS3chr7

47384353

-MAP3K3chr17

61710040

+
intron-3CDSENST00000458317ENST00000361357TNS3chr7

47384353

-MAP3K3chr17

61710040

+
intron-3CDSENST00000458317ENST00000577395TNS3chr7

47384353

-MAP3K3chr17

61710040

+
intron-intronENST00000458317ENST00000577784TNS3chr7

47384353

-MAP3K3chr17

61710040

+
intron-3CDSENST00000474346ENST00000579585TNS3chr7

47384353

-MAP3K3chr17

61710040

+
intron-3CDSENST00000474346ENST00000584573TNS3chr7

47384353

-MAP3K3chr17

61710040

+
intron-3CDSENST00000474346ENST00000361733TNS3chr7

47384353

-MAP3K3chr17

61710040

+
intron-3CDSENST00000474346ENST00000361357TNS3chr7

47384353

-MAP3K3chr17

61710040

+
intron-3CDSENST00000474346ENST00000577395TNS3chr7

47384353

-MAP3K3chr17

61710040

+
intron-intronENST00000474346ENST00000577784TNS3chr7

47384353

-MAP3K3chr17

61710040

+
intron-intronENST00000311160ENST00000361357TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000311160ENST00000361733TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000311160ENST00000577395TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000311160ENST00000577784TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000311160ENST00000579585TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000311160ENST00000584573TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000355730ENST00000361357TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000355730ENST00000361733TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000355730ENST00000577395TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000355730ENST00000577784TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000355730ENST00000579585TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000355730ENST00000584573TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000398879ENST00000361357TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000398879ENST00000361733TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000398879ENST00000577395TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000398879ENST00000577784TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000398879ENST00000579585TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000398879ENST00000584573TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000442536ENST00000361357TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000442536ENST00000361733TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000442536ENST00000577395TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000442536ENST00000577784TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000442536ENST00000579585TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000442536ENST00000584573TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000458317ENST00000361357TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000458317ENST00000361733TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000458317ENST00000577395TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000458317ENST00000577784TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000458317ENST00000579585TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000458317ENST00000584573TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000474346ENST00000361357TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000474346ENST00000361733TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000474346ENST00000577395TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000474346ENST00000577784TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000474346ENST00000579585TNS3chr7

47344601

-MAP3K3chr17

47344601

+
intron-intronENST00000474346ENST00000584573TNS3chr7

47344601

-MAP3K3chr17

47344601

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TNS3-MAP3K3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TNS3chr747384352-MAP3K3chr1761710040+7.81E-101
TNS3chr747384352-MAP3K3chr1761710040+7.81E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TNS3-MAP3K3


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAP3K3

Q99759

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:9006902}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TNS3-MAP3K3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TNS3-MAP3K3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TNS3-MAP3K3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMAP3K3Q99759DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneMAP3K3Q99759DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneMAP3K3Q99759DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for TNS3-MAP3K3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMAP3K3C0014859Esophageal Neoplasms1CTD_human
TgeneMAP3K3C0546837Malignant neoplasm of esophagus1CTD_human