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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TOB2-MRPS18B (FusionGDB2 ID:92334)

Fusion Gene Summary for TOB2-MRPS18B

check button Fusion gene summary
Fusion gene informationFusion gene name: TOB2-MRPS18B
Fusion gene ID: 92334
HgeneTgene
Gene symbol

TOB2

MRPS18B

Gene ID

10766

28973

Gene nametransducer of ERBB2, 2mitochondrial ribosomal protein S18B
SynonymsAPRO5|TOB4|TOBL|TROB2C6orf14|HSPC183|HumanS18a|MRP-S18-2|MRPS18-2|PTD017|S18amt
Cytomap

22q13.2

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionprotein Tob2protein Tob4transducer of erbB-2 228S ribosomal protein S18b, mitochondrial28S ribosomal protein S18-2, mitochondrialMRP-S18-bS18mt-bmitochondrial ribosomal protein S18-2mitochondrial small ribosomal subunit protein bS18bmitochondrial small ribosomal subunit protein bS18m-Bmitochon
Modification date2020031320200320
UniProtAcc.

Q9Y676

Ensembl transtripts involved in fusion geneENST00000327492, ENST00000259873, 
ENST00000506373, ENST00000472229, 
ENST00000454427, ENST00000477010, 
ENST00000437247, ENST00000430402, 
ENST00000489289, ENST00000418070, 
ENST00000426945, ENST00000468755, 
ENST00000412843, ENST00000327800, 
ENST00000469397, ENST00000400594, 
ENST00000451032, ENST00000493769, 
ENST00000440992, ENST00000412451, 
ENST00000428224, ENST00000472444, 
Fusion gene scores* DoF score7 X 7 X 6=2945 X 9 X 4=180
# samples 107
** MAII scorelog2(10/294*10)=-1.55581615506164
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TOB2 [Title/Abstract] AND MRPS18B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTOB2(41842383)-MRPS18B(30592660), # samples:3
TOB2(41842382)-MRPS18B(30592659), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TOB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MRPS18B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-2A-A8W1-01ATOB2chr22

41842383

-MRPS18Bchr6

30592660

+
ChimerDB4PRADTCGA-2A-A8W1TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
ChimerDB4PRADTCGA-2A-A8W1TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
ChimerDB4PRADTCGA-2A-A8W1TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
ChimerDB4PRADTCGA-2A-A8W1-01ATOB2chr22

41842383

-MRPS18Bchr6

30592660

+
ChimerDB4PRADTCGA-2A-A8W1-01ATOB2chr22

41840115

-MRPS18Bchr6

30592659

+
ChimerDB4PRADTCGA-2A-A8W1-01ATOB2chr22

41842378

-MRPS18Bchr6

30592659

+
ChimerDB4PRADTCGA-2A-A8W1-01ATOB2chr22

41842382

-MRPS18Bchr6

30592659

+


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Fusion Gene ORF analysis for TOB2-MRPS18B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000327492ENST00000259873TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-3CDSENST00000327492ENST00000506373TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-3UTRENST00000327492ENST00000472229TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-intronENST00000327492ENST00000454427TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-intronENST00000327492ENST00000477010TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-intronENST00000327492ENST00000437247TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-intronENST00000327492ENST00000430402TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-intronENST00000327492ENST00000489289TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-intronENST00000327492ENST00000418070TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-intronENST00000327492ENST00000426945TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-intronENST00000327492ENST00000468755TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-intronENST00000327492ENST00000412843TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-intronENST00000327492ENST00000327800TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-intronENST00000327492ENST00000469397TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-intronENST00000327492ENST00000400594TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-intronENST00000327492ENST00000451032TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-intronENST00000327492ENST00000493769TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-intronENST00000327492ENST00000440992TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-intronENST00000327492ENST00000412451TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-intronENST00000327492ENST00000428224TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-intronENST00000327492ENST00000472444TOB2chr22

41842383

-MRPS18Bchr6

30592660

+
5UTR-3CDSENST00000327492ENST00000259873TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
5UTR-3CDSENST00000327492ENST00000506373TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
5UTR-3UTRENST00000327492ENST00000472229TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000454427TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000477010TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000437247TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000430402TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000489289TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000418070TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000426945TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000468755TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000412843TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000327800TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000469397TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000400594TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000451032TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000493769TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000440992TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000412451TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000428224TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000472444TOB2chr22

41842382

-MRPS18Bchr6

30592659

+
intron-3CDSENST00000327492ENST00000259873TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
intron-3CDSENST00000327492ENST00000506373TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
intron-3UTRENST00000327492ENST00000472229TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
intron-intronENST00000327492ENST00000454427TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
intron-intronENST00000327492ENST00000477010TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
intron-intronENST00000327492ENST00000437247TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
intron-intronENST00000327492ENST00000430402TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
intron-intronENST00000327492ENST00000489289TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
intron-intronENST00000327492ENST00000418070TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
intron-intronENST00000327492ENST00000426945TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
intron-intronENST00000327492ENST00000468755TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
intron-intronENST00000327492ENST00000412843TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
intron-intronENST00000327492ENST00000327800TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
intron-intronENST00000327492ENST00000469397TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
intron-intronENST00000327492ENST00000400594TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
intron-intronENST00000327492ENST00000451032TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
intron-intronENST00000327492ENST00000493769TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
intron-intronENST00000327492ENST00000440992TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
intron-intronENST00000327492ENST00000412451TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
intron-intronENST00000327492ENST00000428224TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
intron-intronENST00000327492ENST00000472444TOB2chr22

41840115

-MRPS18Bchr6

30592659

+
5UTR-3CDSENST00000327492ENST00000259873TOB2chr22

41842378

-MRPS18Bchr6

30592659

+
5UTR-3CDSENST00000327492ENST00000506373TOB2chr22

41842378

-MRPS18Bchr6

30592659

+
5UTR-3UTRENST00000327492ENST00000472229TOB2chr22

41842378

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000454427TOB2chr22

41842378

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000477010TOB2chr22

41842378

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000437247TOB2chr22

41842378

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000430402TOB2chr22

41842378

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000489289TOB2chr22

41842378

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000418070TOB2chr22

41842378

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000426945TOB2chr22

41842378

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000468755TOB2chr22

41842378

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000412843TOB2chr22

41842378

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000327800TOB2chr22

41842378

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000469397TOB2chr22

41842378

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000400594TOB2chr22

41842378

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000451032TOB2chr22

41842378

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000493769TOB2chr22

41842378

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000440992TOB2chr22

41842378

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000412451TOB2chr22

41842378

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000428224TOB2chr22

41842378

-MRPS18Bchr6

30592659

+
5UTR-intronENST00000327492ENST00000472444TOB2chr22

41842378

-MRPS18Bchr6

30592659

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TOB2-MRPS18B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TOB2chr2241842382-MRPS18Bchr630592659+4.00E-111
TOB2chr2241842382-MRPS18Bchr630592659+4.00E-111
TOB2chr2241842382-MRPS18Bchr630592659+4.00E-111
TOB2chr2241842382-MRPS18Bchr630592659+4.00E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TOB2-MRPS18B


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MRPS18B

Q9Y676

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TOB2-MRPS18B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TOB2-MRPS18B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TOB2-MRPS18B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TOB2-MRPS18B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTOB2C0042900Vitiligo1CTD_human
TgeneMRPS18BC0024623Malignant neoplasm of stomach1CTD_human
TgeneMRPS18BC0038356Stomach Neoplasms1CTD_human
TgeneMRPS18BC0235874Disease Exacerbation1CTD_human
TgeneMRPS18BC1708349Hereditary Diffuse Gastric Cancer1CTD_human