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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BCAR3-ABCA4 (FusionGDB2 ID:9236)

Fusion Gene Summary for BCAR3-ABCA4

check button Fusion gene summary
Fusion gene informationFusion gene name: BCAR3-ABCA4
Fusion gene ID: 9236
HgeneTgene
Gene symbol

BCAR3

ABCA4

Gene ID

8412

24

Gene nameBCAR3 adaptor protein, NSP family memberATP binding cassette subfamily A member 4
SynonymsAND-34|NSP2|SH2D3BABC10|ABCR|ARMD2|CORD3|FFM|RMP|RP19|STGD|STGD1
Cytomap

1p22.1

1p22.1

Type of geneprotein-codingprotein-coding
Descriptionbreast cancer anti-estrogen resistance protein 3BCAR3, NSP family adaptor proteinSH2 domain-containing protein 3Bbreast cancer anti-estrogen resistance 3breast cancer antiestrogen resistance 3 proteindJ1033H22.2 (breast cancer anti-estrogen resistancretinal-specific phospholipid-transporting ATPase ABCA4ATP binding cassette transporterATP-binding cassette sub-family A member 4ATP-binding cassette transporter, retinal-specificATP-binding cassette, sub-family A (ABC1), member 4ATP-binding transpor
Modification date2020031320200315
UniProtAcc

O75815

P78363

Ensembl transtripts involved in fusion geneENST00000260502, ENST00000370244, 
ENST00000370243, ENST00000370247, 
ENST00000539242, ENST00000466632, 
ENST00000370225, ENST00000535881, 
ENST00000536513, ENST00000465352, 
ENST00000535735, 
Fusion gene scores* DoF score11 X 12 X 9=11884 X 5 X 5=100
# samples 127
** MAII scorelog2(12/1188*10)=-3.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BCAR3 [Title/Abstract] AND ABCA4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBCAR3(94054534)-ABCA4(94495187), # samples:3
Anticipated loss of major functional domain due to fusion event.BCAR3-ABCA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
BCAR3-ABCA4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneABCA4

GO:0045332

phospholipid translocation

24097981


check buttonFusion gene breakpoints across BCAR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ABCA4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A3EJ-01ABCAR3chr1

94054534

-ABCA4chr1

94495187

-
ChimerDB4UCECTCGA-AJ-A3EJBCAR3chr1

94054533

-ABCA4chr1

94495187

-
ChimerDB4LIHCTCGA-ZS-A9CF-02ABCAR3chr1

94079404

-ABCA4chr1

94505683

-
ChimerDB4UCECTCGA-AJ-A3EJ-01ABCAR3chr1

94054534

-ABCA4chr1

94495187

-
ChimerDB4UCECTCGA-AJ-A3EJ-01ABCAR3chr1

94054534

-ABCA4chr1

94495187

-
ChimerDB4LIHCTCGA-ZS-A9CF-02ABCAR3chr1

94079404

-ABCA4chr1

94505683

-


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Fusion Gene ORF analysis for BCAR3-ABCA4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000260502ENST00000370225BCAR3chr1

94054534

-ABCA4chr1

94495187

-
5CDS-intronENST00000260502ENST00000535881BCAR3chr1

94054534

-ABCA4chr1

94495187

-
5CDS-intronENST00000260502ENST00000536513BCAR3chr1

94054534

-ABCA4chr1

94495187

-
5CDS-intronENST00000260502ENST00000465352BCAR3chr1

94054534

-ABCA4chr1

94495187

-
5CDS-intronENST00000260502ENST00000535735BCAR3chr1

94054534

-ABCA4chr1

94495187

-
Frame-shiftENST00000370244ENST00000370225BCAR3chr1

94054534

-ABCA4chr1

94495187

-
5CDS-intronENST00000370244ENST00000535881BCAR3chr1

94054534

-ABCA4chr1

94495187

-
5CDS-intronENST00000370244ENST00000536513BCAR3chr1

94054534

-ABCA4chr1

94495187

-
5CDS-intronENST00000370244ENST00000465352BCAR3chr1

94054534

-ABCA4chr1

94495187

-
5CDS-intronENST00000370244ENST00000535735BCAR3chr1

94054534

-ABCA4chr1

94495187

-
In-frameENST00000370243ENST00000370225BCAR3chr1

94054534

-ABCA4chr1

94495187

-
5CDS-intronENST00000370243ENST00000535881BCAR3chr1

94054534

-ABCA4chr1

94495187

-
5CDS-intronENST00000370243ENST00000536513BCAR3chr1

94054534

-ABCA4chr1

94495187

-
5CDS-intronENST00000370243ENST00000465352BCAR3chr1

94054534

-ABCA4chr1

94495187

-
5CDS-intronENST00000370243ENST00000535735BCAR3chr1

94054534

-ABCA4chr1

94495187

-
In-frameENST00000370247ENST00000370225BCAR3chr1

94054534

-ABCA4chr1

94495187

-
5CDS-intronENST00000370247ENST00000535881BCAR3chr1

94054534

-ABCA4chr1

94495187

-
5CDS-intronENST00000370247ENST00000536513BCAR3chr1

94054534

-ABCA4chr1

94495187

-
5CDS-intronENST00000370247ENST00000465352BCAR3chr1

94054534

-ABCA4chr1

94495187

-
5CDS-intronENST00000370247ENST00000535735BCAR3chr1

94054534

-ABCA4chr1

94495187

-
intron-3CDSENST00000539242ENST00000370225BCAR3chr1

94054534

-ABCA4chr1

94495187

-
intron-intronENST00000539242ENST00000535881BCAR3chr1

94054534

-ABCA4chr1

94495187

-
intron-intronENST00000539242ENST00000536513BCAR3chr1

94054534

-ABCA4chr1

94495187

-
intron-intronENST00000539242ENST00000465352BCAR3chr1

94054534

-ABCA4chr1

94495187

-
intron-intronENST00000539242ENST00000535735BCAR3chr1

94054534

-ABCA4chr1

94495187

-
intron-3CDSENST00000466632ENST00000370225BCAR3chr1

94054534

-ABCA4chr1

94495187

-
intron-intronENST00000466632ENST00000535881BCAR3chr1

94054534

-ABCA4chr1

94495187

-
intron-intronENST00000466632ENST00000536513BCAR3chr1

94054534

-ABCA4chr1

94495187

-
intron-intronENST00000466632ENST00000465352BCAR3chr1

94054534

-ABCA4chr1

94495187

-
intron-intronENST00000466632ENST00000535735BCAR3chr1

94054534

-ABCA4chr1

94495187

-
Frame-shiftENST00000260502ENST00000370225BCAR3chr1

94054533

-ABCA4chr1

94495187

-
5CDS-intronENST00000260502ENST00000535881BCAR3chr1

94054533

-ABCA4chr1

94495187

-
5CDS-intronENST00000260502ENST00000536513BCAR3chr1

94054533

-ABCA4chr1

94495187

-
5CDS-intronENST00000260502ENST00000465352BCAR3chr1

94054533

-ABCA4chr1

94495187

-
5CDS-intronENST00000260502ENST00000535735BCAR3chr1

94054533

-ABCA4chr1

94495187

-
Frame-shiftENST00000370244ENST00000370225BCAR3chr1

94054533

-ABCA4chr1

94495187

-
5CDS-intronENST00000370244ENST00000535881BCAR3chr1

94054533

-ABCA4chr1

94495187

-
5CDS-intronENST00000370244ENST00000536513BCAR3chr1

94054533

-ABCA4chr1

94495187

-
5CDS-intronENST00000370244ENST00000465352BCAR3chr1

94054533

-ABCA4chr1

94495187

-
5CDS-intronENST00000370244ENST00000535735BCAR3chr1

94054533

-ABCA4chr1

94495187

-
In-frameENST00000370243ENST00000370225BCAR3chr1

94054533

-ABCA4chr1

94495187

-
5CDS-intronENST00000370243ENST00000535881BCAR3chr1

94054533

-ABCA4chr1

94495187

-
5CDS-intronENST00000370243ENST00000536513BCAR3chr1

94054533

-ABCA4chr1

94495187

-
5CDS-intronENST00000370243ENST00000465352BCAR3chr1

94054533

-ABCA4chr1

94495187

-
5CDS-intronENST00000370243ENST00000535735BCAR3chr1

94054533

-ABCA4chr1

94495187

-
In-frameENST00000370247ENST00000370225BCAR3chr1

94054533

-ABCA4chr1

94495187

-
5CDS-intronENST00000370247ENST00000535881BCAR3chr1

94054533

-ABCA4chr1

94495187

-
5CDS-intronENST00000370247ENST00000536513BCAR3chr1

94054533

-ABCA4chr1

94495187

-
5CDS-intronENST00000370247ENST00000465352BCAR3chr1

94054533

-ABCA4chr1

94495187

-
5CDS-intronENST00000370247ENST00000535735BCAR3chr1

94054533

-ABCA4chr1

94495187

-
intron-3CDSENST00000539242ENST00000370225BCAR3chr1

94054533

-ABCA4chr1

94495187

-
intron-intronENST00000539242ENST00000535881BCAR3chr1

94054533

-ABCA4chr1

94495187

-
intron-intronENST00000539242ENST00000536513BCAR3chr1

94054533

-ABCA4chr1

94495187

-
intron-intronENST00000539242ENST00000465352BCAR3chr1

94054533

-ABCA4chr1

94495187

-
intron-intronENST00000539242ENST00000535735BCAR3chr1

94054533

-ABCA4chr1

94495187

-
intron-3CDSENST00000466632ENST00000370225BCAR3chr1

94054533

-ABCA4chr1

94495187

-
intron-intronENST00000466632ENST00000535881BCAR3chr1

94054533

-ABCA4chr1

94495187

-
intron-intronENST00000466632ENST00000536513BCAR3chr1

94054533

-ABCA4chr1

94495187

-
intron-intronENST00000466632ENST00000465352BCAR3chr1

94054533

-ABCA4chr1

94495187

-
intron-intronENST00000466632ENST00000535735BCAR3chr1

94054533

-ABCA4chr1

94495187

-
intron-3CDSENST00000260502ENST00000370225BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-intronENST00000260502ENST00000535881BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-intronENST00000260502ENST00000536513BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-intronENST00000260502ENST00000465352BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-intronENST00000260502ENST00000535735BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-3CDSENST00000370244ENST00000370225BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-intronENST00000370244ENST00000535881BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-intronENST00000370244ENST00000536513BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-intronENST00000370244ENST00000465352BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-intronENST00000370244ENST00000535735BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-3CDSENST00000370243ENST00000370225BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-intronENST00000370243ENST00000535881BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-intronENST00000370243ENST00000536513BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-intronENST00000370243ENST00000465352BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-intronENST00000370243ENST00000535735BCAR3chr1

94079404

-ABCA4chr1

94505683

-
In-frameENST00000370247ENST00000370225BCAR3chr1

94079404

-ABCA4chr1

94505683

-
5CDS-intronENST00000370247ENST00000535881BCAR3chr1

94079404

-ABCA4chr1

94505683

-
5CDS-intronENST00000370247ENST00000536513BCAR3chr1

94079404

-ABCA4chr1

94505683

-
5CDS-intronENST00000370247ENST00000465352BCAR3chr1

94079404

-ABCA4chr1

94505683

-
5CDS-intronENST00000370247ENST00000535735BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-3CDSENST00000539242ENST00000370225BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-intronENST00000539242ENST00000535881BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-intronENST00000539242ENST00000536513BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-intronENST00000539242ENST00000465352BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-intronENST00000539242ENST00000535735BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-3CDSENST00000466632ENST00000370225BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-intronENST00000466632ENST00000535881BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-intronENST00000466632ENST00000536513BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-intronENST00000466632ENST00000465352BCAR3chr1

94079404

-ABCA4chr1

94505683

-
intron-intronENST00000466632ENST00000535735BCAR3chr1

94079404

-ABCA4chr1

94505683

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370243BCAR3chr194054534-ENST00000370225ABCA4chr194495187-407412046836731201
ENST00000370247BCAR3chr194054534-ENST00000370225ABCA4chr194495187-369382316732921041
ENST00000370243BCAR3chr194054533-ENST00000370225ABCA4chr194495187-407412046836731201
ENST00000370247BCAR3chr194054533-ENST00000370225ABCA4chr194495187-369382316732921041
ENST00000370247BCAR3chr194079404-ENST00000370225ABCA4chr194505683-395125116735501127

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370243ENST00000370225BCAR3chr194054534-ABCA4chr194495187-0.0018555680.9981444
ENST00000370247ENST00000370225BCAR3chr194054534-ABCA4chr194495187-0.0012947020.99870527
ENST00000370243ENST00000370225BCAR3chr194054533-ABCA4chr194495187-0.0018555680.9981444
ENST00000370247ENST00000370225BCAR3chr194054533-ABCA4chr194495187-0.0012947020.99870527
ENST00000370247ENST00000370225BCAR3chr194079404-ABCA4chr194505683-0.0014844650.99851555

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Fusion Genomic Features for BCAR3-ABCA4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BCAR3-ABCA4


check button Go to

FGviewer for the breakpoints of chr1:94054534-chr1:94495187

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BCAR3

O75815

ABCA4

P78363

FUNCTION: Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:Q9QZK2, ECO:0000269|PubMed:18722344, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:24216110}.FUNCTION: Catalyzes the translocation of specific phospholipids from the extracellular/lumenal to the cytoplasmic leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylethanolamine (PubMed:24097981). In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery. {ECO:0000269|PubMed:10075733, ECO:0000269|PubMed:24097981}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBCAR3chr1:94054533chr1:94495187ENST00000260502-512154_253309.6666666666667826.0DomainSH2
HgeneBCAR3chr1:94054533chr1:94495187ENST00000370243-512154_253309.6666666666667826.0DomainSH2
HgeneBCAR3chr1:94054533chr1:94495187ENST00000370244-714154_253309.6666666666667826.0DomainSH2
HgeneBCAR3chr1:94054534chr1:94495187ENST00000260502-512154_253309.6666666666667826.0DomainSH2
HgeneBCAR3chr1:94054534chr1:94495187ENST00000370243-512154_253309.6666666666667826.0DomainSH2
HgeneBCAR3chr1:94054534chr1:94495187ENST00000370244-714154_253309.6666666666667826.0DomainSH2
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501938_21701450.66666666666672274.0DomainABC transporter 2
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501938_21701450.66666666666672274.0DomainABC transporter 2
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501938_21701174.02274.0DomainABC transporter 2
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501972_19791450.66666666666672274.0Nucleotide bindingATP 2
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501972_19791450.66666666666672274.0Nucleotide bindingATP 2
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501972_19791174.02274.0Nucleotide bindingATP 2
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501895_22731450.66666666666672274.0Topological domainNote=Cytoplasmic
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501895_22731450.66666666666672274.0Topological domainNote=Cytoplasmic
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501398_17271174.02274.0Topological domainNote=Extracellular
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501895_22731174.02274.0Topological domainNote=Cytoplasmic
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501728_17481450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501760_17801450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501793_18131450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501832_18521450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501874_18941450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501728_17481450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501760_17801450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501793_18131450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501832_18521450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501874_18941450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501377_13971174.02274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501728_17481174.02274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501760_17801174.02274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501793_18131174.02274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501832_18521174.02274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501874_18941174.02274.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBCAR3chr1:94054533chr1:94495187ENST00000260502-512479_482309.6666666666667826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94054533chr1:94495187ENST00000370243-512479_482309.6666666666667826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94054533chr1:94495187ENST00000370244-714479_482309.6666666666667826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94054533chr1:94495187ENST00000370247-310479_482218.66666666666666735.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94054533chr1:94495187ENST00000539242-18479_4820502.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94054534chr1:94495187ENST00000260502-512479_482309.6666666666667826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94054534chr1:94495187ENST00000370243-512479_482309.6666666666667826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94054534chr1:94495187ENST00000370244-714479_482309.6666666666667826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94054534chr1:94495187ENST00000370247-310479_482218.66666666666666735.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94054534chr1:94495187ENST00000539242-18479_4820502.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94079404chr1:94505683ENST00000260502-112479_4820826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94079404chr1:94505683ENST00000370243-112479_4820826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94079404chr1:94505683ENST00000370244-114479_4820826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94079404chr1:94505683ENST00000370247-110479_48228.0735.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94079404chr1:94505683ENST00000539242-18479_4820502.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94054533chr1:94495187ENST00000260502-512548_818309.6666666666667826.0DomainRas-GEF
HgeneBCAR3chr1:94054533chr1:94495187ENST00000370243-512548_818309.6666666666667826.0DomainRas-GEF
HgeneBCAR3chr1:94054533chr1:94495187ENST00000370244-714548_818309.6666666666667826.0DomainRas-GEF
HgeneBCAR3chr1:94054533chr1:94495187ENST00000370247-310154_253218.66666666666666735.0DomainSH2
HgeneBCAR3chr1:94054533chr1:94495187ENST00000370247-310548_818218.66666666666666735.0DomainRas-GEF
HgeneBCAR3chr1:94054533chr1:94495187ENST00000539242-18154_2530502.0DomainSH2
HgeneBCAR3chr1:94054533chr1:94495187ENST00000539242-18548_8180502.0DomainRas-GEF
HgeneBCAR3chr1:94054534chr1:94495187ENST00000260502-512548_818309.6666666666667826.0DomainRas-GEF
HgeneBCAR3chr1:94054534chr1:94495187ENST00000370243-512548_818309.6666666666667826.0DomainRas-GEF
HgeneBCAR3chr1:94054534chr1:94495187ENST00000370244-714548_818309.6666666666667826.0DomainRas-GEF
HgeneBCAR3chr1:94054534chr1:94495187ENST00000370247-310154_253218.66666666666666735.0DomainSH2
HgeneBCAR3chr1:94054534chr1:94495187ENST00000370247-310548_818218.66666666666666735.0DomainRas-GEF
HgeneBCAR3chr1:94054534chr1:94495187ENST00000539242-18154_2530502.0DomainSH2
HgeneBCAR3chr1:94054534chr1:94495187ENST00000539242-18548_8180502.0DomainRas-GEF
HgeneBCAR3chr1:94079404chr1:94505683ENST00000260502-112154_2530826.0DomainSH2
HgeneBCAR3chr1:94079404chr1:94505683ENST00000260502-112548_8180826.0DomainRas-GEF
HgeneBCAR3chr1:94079404chr1:94505683ENST00000370243-112154_2530826.0DomainSH2
HgeneBCAR3chr1:94079404chr1:94505683ENST00000370243-112548_8180826.0DomainRas-GEF
HgeneBCAR3chr1:94079404chr1:94505683ENST00000370244-114154_2530826.0DomainSH2
HgeneBCAR3chr1:94079404chr1:94505683ENST00000370244-114548_8180826.0DomainRas-GEF
HgeneBCAR3chr1:94079404chr1:94505683ENST00000370247-110154_25328.0735.0DomainSH2
HgeneBCAR3chr1:94079404chr1:94505683ENST00000370247-110548_81828.0735.0DomainRas-GEF
HgeneBCAR3chr1:94079404chr1:94505683ENST00000539242-18154_2530502.0DomainSH2
HgeneBCAR3chr1:94079404chr1:94505683ENST00000539242-18548_8180502.0DomainRas-GEF
TgeneABCA4chr1:94054533chr1:94495187ENST000003702252850929_11601450.66666666666672274.0DomainABC transporter 1
TgeneABCA4chr1:94054534chr1:94495187ENST000003702252850929_11601450.66666666666672274.0DomainABC transporter 1
TgeneABCA4chr1:94079404chr1:94505683ENST000003702252250929_11601174.02274.0DomainABC transporter 1
TgeneABCA4chr1:94054533chr1:94495187ENST000003702252850963_9701450.66666666666672274.0Nucleotide bindingATP 1
TgeneABCA4chr1:94054534chr1:94495187ENST000003702252850963_9701450.66666666666672274.0Nucleotide bindingATP 1
TgeneABCA4chr1:94079404chr1:94505683ENST000003702252250963_9701174.02274.0Nucleotide bindingATP 1
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501398_17271450.66666666666672274.0Topological domainNote=Extracellular
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501_211450.66666666666672274.0Topological domainNote=Cytoplasmic
TgeneABCA4chr1:94054533chr1:94495187ENST00000370225285043_6461450.66666666666672274.0Topological domainNote=Extracellular
TgeneABCA4chr1:94054533chr1:94495187ENST000003702252850857_13761450.66666666666672274.0Topological domainNote=Cytoplasmic
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501398_17271450.66666666666672274.0Topological domainNote=Extracellular
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501_211450.66666666666672274.0Topological domainNote=Cytoplasmic
TgeneABCA4chr1:94054534chr1:94495187ENST00000370225285043_6461450.66666666666672274.0Topological domainNote=Extracellular
TgeneABCA4chr1:94054534chr1:94495187ENST000003702252850857_13761450.66666666666672274.0Topological domainNote=Cytoplasmic
TgeneABCA4chr1:94079404chr1:94505683ENST0000037022522501_211174.02274.0Topological domainNote=Cytoplasmic
TgeneABCA4chr1:94079404chr1:94505683ENST00000370225225043_6461174.02274.0Topological domainNote=Extracellular
TgeneABCA4chr1:94079404chr1:94505683ENST000003702252250857_13761174.02274.0Topological domainNote=Cytoplasmic
TgeneABCA4chr1:94054533chr1:94495187ENST0000037022528501377_13971450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054533chr1:94495187ENST00000370225285022_421450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054533chr1:94495187ENST000003702252850647_6671450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054533chr1:94495187ENST000003702252850700_7201450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054533chr1:94495187ENST000003702252850731_7511450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054533chr1:94495187ENST000003702252850760_7801450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054533chr1:94495187ENST000003702252850836_8561450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST0000037022528501377_13971450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST00000370225285022_421450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST000003702252850647_6671450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST000003702252850700_7201450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST000003702252850731_7511450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST000003702252850760_7801450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94054534chr1:94495187ENST000003702252850836_8561450.66666666666672274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST00000370225225022_421174.02274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST000003702252250647_6671174.02274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST000003702252250700_7201174.02274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST000003702252250731_7511174.02274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST000003702252250760_7801174.02274.0TransmembraneHelical
TgeneABCA4chr1:94079404chr1:94505683ENST000003702252250836_8561174.02274.0TransmembraneHelical


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Fusion Gene Sequence for BCAR3-ABCA4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000370243_ENST00000370225_TCGA-AJ-A3EJ-01A_BCAR3_chr1_94054534_-_ABCA4_chr1_94495187_length(transcript)=4074nt_BP=1204nt
GAGCGCGCTGGGACTCCCCGAGACGTGGCCCACGGCGGGGAGCGCTCAGCGATTGGCGGCCAGGCATCTTGCTCGGTGGCACTCGAGCGG
CATCTTCCCGGGCGCTGGCCTCGCCCGACCCCCTGCCCGTCGGAGCTGCTCTGCCGGCCACCCCGCCCTGTCCCGCCCGTCCCCTCTTCG
CAGAAGCCGGCCGGGGTCGGGCAGATGCGAGGGCCCAGAGCGCTCTGGTGGAAGCCCAAGGCTCCGAGGAGGCGAGTTTCTCCGAGTTGA
GAATTATGGCTGCAGGAAAATTTGCAAGCCTTCCCAGAAACATGCCGGTGAATCACCAGTTCCCCCTGGCCTCATCCATGGACCTTCTGA
GCAGCAGGTCCCCTCTCGCTGAGCATCGCCCAGATGCCTATCAAGATGTGTCTATACATGGCACCCTTCCACGGAAGAAAAAAGGTCCTC
CTCCCATAAGGTCCTGTGATGACTTCAGTCACATGGGCACCCTCCCCCACTCCAAATCCCCACGGCAGAACTCGCCTGTGACCCAGGATG
GCATCCAGGAGAGCCCATGGCAGGACCGGCACGGCGAAACCTTCACCTTCAGGGATCCACATCTTCTGGACCCAACTGTGGAATATGTGA
AGTTCTCCAAGGAGAGGCACATCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACC
TGCGCAGCCATGCCTGGTACCACGGCCGCATCCCCCGACAGGTGTCTGAAAACCTTGTGCAGCGAGATGGTGACTTCCTAGTTCGTGACT
CTCTGTCCAGCCCTGGGAACTTTGTCCTGACCTGTCAGTGGAAGAACCTCGCTCAGCACTTCAAAATCAACCGGACAGTTCTGCGACTCA
GCGAGGCCTACAGCCGCGTGCAGTACCAGTTCGAGATGGAGAGCTTCGACTCCATCCCCGGCCTGGTGCGCTGCTACGTGGGCAACCGCC
GGCCCATCTCCCAGCAGAGTGGCGCCATCATCTTCCAGCCCATCAACAGGACGGTGCCTCTGCGGTGCCTGGAGGAGCATTATGGCACCT
CCCCAGGCCAGGCCCGGGAGGGCAGCCTCACCAAGGGAAGGCCGGATGTGGCCAAGAGGCTGAGCCTCACCATGGGTGGCGTCCAGGCCC
GAGAGCAGAATTTGCCCAGGGGAAACCTCCTCAGGGAGTACCCCTGTGGCAACTCAACACCCTGGAAGACTCCTTCTGTGTCCCCAAACA
TCACCCAGCTGTTCCAGAAGCAGAAATGGACACAGGTCAACCCTTCACCATCCTGCAGGTGCAGCACCAGGGAGAAGCTCACCATGCTGC
CAGAGTGCCCCGAGGGTGCCGGGGGCCTCCCGCCCCCCCAGAGAACACAGCGCAGCACGGAAATTCTACAAGACCTGACGGACAGGAACA
TCTCCGACTTCTTGGTAAAAACGTATCCTGCTCTTATAAGAAGCAGCTTAAAGAGCAAATTCTGGGTCAATGAACAGAGGTATGGAGGAA
TTTCCATTGGAGGAAAGCTCCCAGTCGTCCCCATCACGGGGGAAGCACTTGTTGGGTTTTTAAGCGACCTTGGCCGGATCATGAATGTGA
GCGGGGGCCCTATCACTAGAGAGGCCTCTAAAGAAATACCTGATTTCCTTAAACATCTAGAAACTGAAGACAACATTAAGGTGTGGTTTA
ATAACAAAGGCTGGCATGCCCTGGTCAGCTTTCTCAATGTGGCCCACAACGCCATCTTACGGGCCAGCCTGCCTAAGGACAGGAGCCCCG
AGGAGTATGGAATCACCGTCATTAGCCAACCCCTGAACCTGACCAAGGAGCAGCTCTCAGAGATTACAGTGCTGACCACTTCAGTGGATG
CTGTGGTTGCCATCTGCGTGATTTTCTCCATGTCCTTCGTCCCAGCCAGCTTTGTCCTTTATTTGATCCAGGAGCGGGTGAACAAATCCA
AGCACCTCCAGTTTATCAGTGGAGTGAGCCCCACCACCTACTGGGTGACCAACTTCCTCTGGGACATCATGAATTATTCCGTGAGTGCTG
GGCTGGTGGTGGGCATCTTCATCGGGTTTCAGAAGAAAGCCTACACTTCTCCAGAAAACCTTCCTGCCCTTGTGGCACTGCTCCTGCTGT
ATGGATGGGCGGTCATTCCCATGATGTACCCAGCATCCTTCCTGTTTGATGTCCCCAGCACAGCCTATGTGGCTTTATCTTGTGCTAATC
TGTTCATCGGCATCAACAGCAGTGCTATTACCTTCATCTTGGAATTATTTGAGAATAACCGGACGCTGCTCAGGTTCAACGCCGTGCTGA
GGAAGCTGCTCATTGTCTTCCCCCACTTCTGCCTGGGCCGGGGCCTCATTGACCTTGCACTGAGCCAGGCTGTGACAGATGTCTATGCCC
GGTTTGGTGAGGAGCACTCTGCAAATCCGTTCCACTGGGACCTGATTGGGAAGAACCTGTTTGCCATGGTGGTGGAAGGGGTGGTGTACT
TCCTCCTGACCCTGCTGGTCCAGCGCCACTTCTTCCTCTCCCAATGGATTGCCGAGCCCACTAAGGAGCCCATTGTTGATGAAGATGATG
ATGTGGCTGAAGAAAGACAAAGAATTATTACTGGTGGAAATAAAACTGACATCTTAAGGCTACATGAACTAACCAAGATTTATCCAGGCA
CCTCCAGCCCAGCAGTGGACAGGCTGTGTGTCGGAGTTCGCCCTGGAGAGTGCTTTGGCCTCCTGGGAGTGAATGGTGCCGGCAAAACAA
CCACATTCAAGATGCTCACTGGGGACACCACAGTGACCTCAGGGGATGCCACCGTAGCAGGCAAGAGTATTTTAACCAATATTTCTGAAG
TCCATCAAAATATGGGCTACTGTCCTCAGTTTGATGCAATTGATGAGCTGCTCACAGGACGAGAACATCTTTACCTTTATGCCCGGCTTC
GAGGTGTACCAGCAGAAGAAATCGAAAAGGTTGCAAACTGGAGTATTAAGAGCCTGGGCCTGACTGTCTACGCCGACTGCCTGGCTGGCA
CGTACAGTGGGGGCAACAAGCGGAAACTCTCCACAGCCATCGCACTCATTGGCTGCCCACCGCTGGTGCTGCTGGATGAGCCCACCACAG
GGATGGACCCCCAGGCACGCCGCATGCTGTGGAACGTCATCGTGAGCATCATCAGAGAAGGGAGGGCTGTGGTCCTCACATCCCACAGCA
TGGAAGAATGTGAGGCACTGTGTACCCGGCTGGCCATCATGGTAAAGGGCGCCTTTCGATGTATGGGCACCATTCAGCATCTCAAGTCCA
AATTTGGAGATGGCTATATCGTCACAATGAAGATCAAATCCCCGAAGGACGACCTGCTTCCTGACCTGAACCCTGTGGAGCAGTTCTTCC
AGGGGAACTTCCCAGGCAGTGTGCAGAGGGAGAGGCACTACAACATGCTCCAGTTCCAGGTCTCCTCCTCCTCCCTGGCGAGGATCTTCC
AGCTCCTCCTCTCCCACAAGGACAGCCTGCTCATCGAGGAGTACTCAGTCACACAGACCACACTGGACCAGGTGTTTGTAAATTTTGCTA
AACAGCAGACTGAAAGTCATGACCTCCCTCTGCACCCTCGAGCTGCTGGAGCCAGTCGACAAGCCCAGGACTGATCTTTCACACCGCTCG
TTCCTGCAGCCAGAAAGGAACTCTGGGCAGCTGGAGGCGCAGGAGCCTGTGCCCATATGGTCATCCAAATGGACTGGCCAGCGTAAATGA
CCCCACTGCAGCAGAAAACAAACACACGAGGAGCATGCAGCGAATTCAGAAAGAGGTCTTTCAGAAGGAAACCGAAACTGACTTGCTCAC
CTGGAACACCTGATGGTGAAACCAAACAAATACAAAATCCTTCTCCAGACCCCAGAACTAGAAACCCCGGGCCATCCCACTAGCAGCTTT
GGCCTCCATATTGCTCTCATTTCAAGCAGATCTGCTTTTCTGCATGTTTGTCTGTGTGTCTGCGTTGTGTGTGATTTTCATGGAAAAATA

>In-frame_ENST00000370243_ENST00000370225_TCGA-AJ-A3EJ-01A_BCAR3_chr1_94054534_-_ABCA4_chr1_94495187_length(amino acids)=1201AA_start in transcript=68_stop in transcript=3673
MLGGTRAASSRALASPDPLPVGAALPATPPCPARPLFAEAGRGRADARAQSALVEAQGSEEASFSELRIMAAGKFASLPRNMPVNHQFPL
ASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLL
DPTVEYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKI
NRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSL
TMGGVQAREQNLPRGNLLREYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGAGGLPPPQRTQRSTEIL
QDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLETE
DNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLYLI
QERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAY
VALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAM
VVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRLCVGVRPGECFGLLG
VNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTV
YADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMG
TIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLLLSHKDSLLIEEYSVTQTTLD

--------------------------------------------------------------
>In-frame_ENST00000370247_ENST00000370225_TCGA-AJ-A3EJ-01A_BCAR3_chr1_94054534_-_ABCA4_chr1_94495187_length(transcript)=3693nt_BP=823nt
AGACTAGCCTGGGAGAAGGAGCCGACTCACTCCCCCGGCTGCCGACTTCCCTGACTTCTGGGCAGAAACAGCACAGCTGCTGTGGTGGGC
TAGGGCTTTAACGTCCGAAGCCCCCTTTCTTTTAACCCTAAAGAAAGTGTGTGGTCCCCGGGACTGAAGACCGAAAGATGCCTAAGGAAT
GCAGTGCTTTCCACGCCCTCTCAGCAGCTCTGTGCTGCTTCTATCACCGCAAGTCTTTCATTGGAGTCAAGTTCTCCAAGGAGAGGCACA
TCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACCTGCGCAGCCATGCCTGGTACC
ACGGCCGCATCCCCCGACAGGTGTCTGAAAACCTTGTGCAGCGAGATGGTGACTTCCTAGTTCGTGACTCTCTGTCCAGCCCTGGGAACT
TTGTCCTGACCTGTCAGTGGAAGAACCTCGCTCAGCACTTCAAAATCAACCGGACAGTTCTGCGACTCAGCGAGGCCTACAGCCGCGTGC
AGTACCAGTTCGAGATGGAGAGCTTCGACTCCATCCCCGGCCTGGTGCGCTGCTACGTGGGCAACCGCCGGCCCATCTCCCAGCAGAGTG
GCGCCATCATCTTCCAGCCCATCAACAGGACGGTGCCTCTGCGGTGCCTGGAGGAGCATTATGGCACCTCCCCAGGCCAGGCCCGGGAGG
GCAGCCTCACCAAGGGAAGGCCGGATGTGGCCAAGAGGCTGAGCCTCACCATGGGTGGCGTCCAGGCCCGAGAGCAGAATTTGCCCAGGG
GAAACCTCCTCAGGGAGTACCCCTGTGGCAACTCAACACCCTGGAAGACTCCTTCTGTGTCCCCAAACATCACCCAGCTGTTCCAGAAGC
AGAAATGGACACAGGTCAACCCTTCACCATCCTGCAGGTGCAGCACCAGGGAGAAGCTCACCATGCTGCCAGAGTGCCCCGAGGGTGCCG
GGGGCCTCCCGCCCCCCCAGAGAACACAGCGCAGCACGGAAATTCTACAAGACCTGACGGACAGGAACATCTCCGACTTCTTGGTAAAAA
CGTATCCTGCTCTTATAAGAAGCAGCTTAAAGAGCAAATTCTGGGTCAATGAACAGAGGTATGGAGGAATTTCCATTGGAGGAAAGCTCC
CAGTCGTCCCCATCACGGGGGAAGCACTTGTTGGGTTTTTAAGCGACCTTGGCCGGATCATGAATGTGAGCGGGGGCCCTATCACTAGAG
AGGCCTCTAAAGAAATACCTGATTTCCTTAAACATCTAGAAACTGAAGACAACATTAAGGTGTGGTTTAATAACAAAGGCTGGCATGCCC
TGGTCAGCTTTCTCAATGTGGCCCACAACGCCATCTTACGGGCCAGCCTGCCTAAGGACAGGAGCCCCGAGGAGTATGGAATCACCGTCA
TTAGCCAACCCCTGAACCTGACCAAGGAGCAGCTCTCAGAGATTACAGTGCTGACCACTTCAGTGGATGCTGTGGTTGCCATCTGCGTGA
TTTTCTCCATGTCCTTCGTCCCAGCCAGCTTTGTCCTTTATTTGATCCAGGAGCGGGTGAACAAATCCAAGCACCTCCAGTTTATCAGTG
GAGTGAGCCCCACCACCTACTGGGTGACCAACTTCCTCTGGGACATCATGAATTATTCCGTGAGTGCTGGGCTGGTGGTGGGCATCTTCA
TCGGGTTTCAGAAGAAAGCCTACACTTCTCCAGAAAACCTTCCTGCCCTTGTGGCACTGCTCCTGCTGTATGGATGGGCGGTCATTCCCA
TGATGTACCCAGCATCCTTCCTGTTTGATGTCCCCAGCACAGCCTATGTGGCTTTATCTTGTGCTAATCTGTTCATCGGCATCAACAGCA
GTGCTATTACCTTCATCTTGGAATTATTTGAGAATAACCGGACGCTGCTCAGGTTCAACGCCGTGCTGAGGAAGCTGCTCATTGTCTTCC
CCCACTTCTGCCTGGGCCGGGGCCTCATTGACCTTGCACTGAGCCAGGCTGTGACAGATGTCTATGCCCGGTTTGGTGAGGAGCACTCTG
CAAATCCGTTCCACTGGGACCTGATTGGGAAGAACCTGTTTGCCATGGTGGTGGAAGGGGTGGTGTACTTCCTCCTGACCCTGCTGGTCC
AGCGCCACTTCTTCCTCTCCCAATGGATTGCCGAGCCCACTAAGGAGCCCATTGTTGATGAAGATGATGATGTGGCTGAAGAAAGACAAA
GAATTATTACTGGTGGAAATAAAACTGACATCTTAAGGCTACATGAACTAACCAAGATTTATCCAGGCACCTCCAGCCCAGCAGTGGACA
GGCTGTGTGTCGGAGTTCGCCCTGGAGAGTGCTTTGGCCTCCTGGGAGTGAATGGTGCCGGCAAAACAACCACATTCAAGATGCTCACTG
GGGACACCACAGTGACCTCAGGGGATGCCACCGTAGCAGGCAAGAGTATTTTAACCAATATTTCTGAAGTCCATCAAAATATGGGCTACT
GTCCTCAGTTTGATGCAATTGATGAGCTGCTCACAGGACGAGAACATCTTTACCTTTATGCCCGGCTTCGAGGTGTACCAGCAGAAGAAA
TCGAAAAGGTTGCAAACTGGAGTATTAAGAGCCTGGGCCTGACTGTCTACGCCGACTGCCTGGCTGGCACGTACAGTGGGGGCAACAAGC
GGAAACTCTCCACAGCCATCGCACTCATTGGCTGCCCACCGCTGGTGCTGCTGGATGAGCCCACCACAGGGATGGACCCCCAGGCACGCC
GCATGCTGTGGAACGTCATCGTGAGCATCATCAGAGAAGGGAGGGCTGTGGTCCTCACATCCCACAGCATGGAAGAATGTGAGGCACTGT
GTACCCGGCTGGCCATCATGGTAAAGGGCGCCTTTCGATGTATGGGCACCATTCAGCATCTCAAGTCCAAATTTGGAGATGGCTATATCG
TCACAATGAAGATCAAATCCCCGAAGGACGACCTGCTTCCTGACCTGAACCCTGTGGAGCAGTTCTTCCAGGGGAACTTCCCAGGCAGTG
TGCAGAGGGAGAGGCACTACAACATGCTCCAGTTCCAGGTCTCCTCCTCCTCCCTGGCGAGGATCTTCCAGCTCCTCCTCTCCCACAAGG
ACAGCCTGCTCATCGAGGAGTACTCAGTCACACAGACCACACTGGACCAGGTGTTTGTAAATTTTGCTAAACAGCAGACTGAAAGTCATG
ACCTCCCTCTGCACCCTCGAGCTGCTGGAGCCAGTCGACAAGCCCAGGACTGATCTTTCACACCGCTCGTTCCTGCAGCCAGAAAGGAAC
TCTGGGCAGCTGGAGGCGCAGGAGCCTGTGCCCATATGGTCATCCAAATGGACTGGCCAGCGTAAATGACCCCACTGCAGCAGAAAACAA
ACACACGAGGAGCATGCAGCGAATTCAGAAAGAGGTCTTTCAGAAGGAAACCGAAACTGACTTGCTCACCTGGAACACCTGATGGTGAAA
CCAAACAAATACAAAATCCTTCTCCAGACCCCAGAACTAGAAACCCCGGGCCATCCCACTAGCAGCTTTGGCCTCCATATTGCTCTCATT
TCAAGCAGATCTGCTTTTCTGCATGTTTGTCTGTGTGTCTGCGTTGTGTGTGATTTTCATGGAAAAATAAAATGCAAATGCACTCATCAC

>In-frame_ENST00000370247_ENST00000370225_TCGA-AJ-A3EJ-01A_BCAR3_chr1_94054534_-_ABCA4_chr1_94495187_length(amino acids)=1041AA_start in transcript=167_stop in transcript=3292
MPKECSAFHALSAALCCFYHRKSFIGVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLS
SPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPG
QAREGSLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLREYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPEC
PEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGG
PITREASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVV
AICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGW
AVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFG
EEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSS
PAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGV
PAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEE
CEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLL

--------------------------------------------------------------
>In-frame_ENST00000370243_ENST00000370225_TCGA-AJ-A3EJ_BCAR3_chr1_94054533_-_ABCA4_chr1_94495187_length(transcript)=4074nt_BP=1204nt
GAGCGCGCTGGGACTCCCCGAGACGTGGCCCACGGCGGGGAGCGCTCAGCGATTGGCGGCCAGGCATCTTGCTCGGTGGCACTCGAGCGG
CATCTTCCCGGGCGCTGGCCTCGCCCGACCCCCTGCCCGTCGGAGCTGCTCTGCCGGCCACCCCGCCCTGTCCCGCCCGTCCCCTCTTCG
CAGAAGCCGGCCGGGGTCGGGCAGATGCGAGGGCCCAGAGCGCTCTGGTGGAAGCCCAAGGCTCCGAGGAGGCGAGTTTCTCCGAGTTGA
GAATTATGGCTGCAGGAAAATTTGCAAGCCTTCCCAGAAACATGCCGGTGAATCACCAGTTCCCCCTGGCCTCATCCATGGACCTTCTGA
GCAGCAGGTCCCCTCTCGCTGAGCATCGCCCAGATGCCTATCAAGATGTGTCTATACATGGCACCCTTCCACGGAAGAAAAAAGGTCCTC
CTCCCATAAGGTCCTGTGATGACTTCAGTCACATGGGCACCCTCCCCCACTCCAAATCCCCACGGCAGAACTCGCCTGTGACCCAGGATG
GCATCCAGGAGAGCCCATGGCAGGACCGGCACGGCGAAACCTTCACCTTCAGGGATCCACATCTTCTGGACCCAACTGTGGAATATGTGA
AGTTCTCCAAGGAGAGGCACATCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACC
TGCGCAGCCATGCCTGGTACCACGGCCGCATCCCCCGACAGGTGTCTGAAAACCTTGTGCAGCGAGATGGTGACTTCCTAGTTCGTGACT
CTCTGTCCAGCCCTGGGAACTTTGTCCTGACCTGTCAGTGGAAGAACCTCGCTCAGCACTTCAAAATCAACCGGACAGTTCTGCGACTCA
GCGAGGCCTACAGCCGCGTGCAGTACCAGTTCGAGATGGAGAGCTTCGACTCCATCCCCGGCCTGGTGCGCTGCTACGTGGGCAACCGCC
GGCCCATCTCCCAGCAGAGTGGCGCCATCATCTTCCAGCCCATCAACAGGACGGTGCCTCTGCGGTGCCTGGAGGAGCATTATGGCACCT
CCCCAGGCCAGGCCCGGGAGGGCAGCCTCACCAAGGGAAGGCCGGATGTGGCCAAGAGGCTGAGCCTCACCATGGGTGGCGTCCAGGCCC
GAGAGCAGAATTTGCCCAGGGGAAACCTCCTCAGGGAGTACCCCTGTGGCAACTCAACACCCTGGAAGACTCCTTCTGTGTCCCCAAACA
TCACCCAGCTGTTCCAGAAGCAGAAATGGACACAGGTCAACCCTTCACCATCCTGCAGGTGCAGCACCAGGGAGAAGCTCACCATGCTGC
CAGAGTGCCCCGAGGGTGCCGGGGGCCTCCCGCCCCCCCAGAGAACACAGCGCAGCACGGAAATTCTACAAGACCTGACGGACAGGAACA
TCTCCGACTTCTTGGTAAAAACGTATCCTGCTCTTATAAGAAGCAGCTTAAAGAGCAAATTCTGGGTCAATGAACAGAGGTATGGAGGAA
TTTCCATTGGAGGAAAGCTCCCAGTCGTCCCCATCACGGGGGAAGCACTTGTTGGGTTTTTAAGCGACCTTGGCCGGATCATGAATGTGA
GCGGGGGCCCTATCACTAGAGAGGCCTCTAAAGAAATACCTGATTTCCTTAAACATCTAGAAACTGAAGACAACATTAAGGTGTGGTTTA
ATAACAAAGGCTGGCATGCCCTGGTCAGCTTTCTCAATGTGGCCCACAACGCCATCTTACGGGCCAGCCTGCCTAAGGACAGGAGCCCCG
AGGAGTATGGAATCACCGTCATTAGCCAACCCCTGAACCTGACCAAGGAGCAGCTCTCAGAGATTACAGTGCTGACCACTTCAGTGGATG
CTGTGGTTGCCATCTGCGTGATTTTCTCCATGTCCTTCGTCCCAGCCAGCTTTGTCCTTTATTTGATCCAGGAGCGGGTGAACAAATCCA
AGCACCTCCAGTTTATCAGTGGAGTGAGCCCCACCACCTACTGGGTGACCAACTTCCTCTGGGACATCATGAATTATTCCGTGAGTGCTG
GGCTGGTGGTGGGCATCTTCATCGGGTTTCAGAAGAAAGCCTACACTTCTCCAGAAAACCTTCCTGCCCTTGTGGCACTGCTCCTGCTGT
ATGGATGGGCGGTCATTCCCATGATGTACCCAGCATCCTTCCTGTTTGATGTCCCCAGCACAGCCTATGTGGCTTTATCTTGTGCTAATC
TGTTCATCGGCATCAACAGCAGTGCTATTACCTTCATCTTGGAATTATTTGAGAATAACCGGACGCTGCTCAGGTTCAACGCCGTGCTGA
GGAAGCTGCTCATTGTCTTCCCCCACTTCTGCCTGGGCCGGGGCCTCATTGACCTTGCACTGAGCCAGGCTGTGACAGATGTCTATGCCC
GGTTTGGTGAGGAGCACTCTGCAAATCCGTTCCACTGGGACCTGATTGGGAAGAACCTGTTTGCCATGGTGGTGGAAGGGGTGGTGTACT
TCCTCCTGACCCTGCTGGTCCAGCGCCACTTCTTCCTCTCCCAATGGATTGCCGAGCCCACTAAGGAGCCCATTGTTGATGAAGATGATG
ATGTGGCTGAAGAAAGACAAAGAATTATTACTGGTGGAAATAAAACTGACATCTTAAGGCTACATGAACTAACCAAGATTTATCCAGGCA
CCTCCAGCCCAGCAGTGGACAGGCTGTGTGTCGGAGTTCGCCCTGGAGAGTGCTTTGGCCTCCTGGGAGTGAATGGTGCCGGCAAAACAA
CCACATTCAAGATGCTCACTGGGGACACCACAGTGACCTCAGGGGATGCCACCGTAGCAGGCAAGAGTATTTTAACCAATATTTCTGAAG
TCCATCAAAATATGGGCTACTGTCCTCAGTTTGATGCAATTGATGAGCTGCTCACAGGACGAGAACATCTTTACCTTTATGCCCGGCTTC
GAGGTGTACCAGCAGAAGAAATCGAAAAGGTTGCAAACTGGAGTATTAAGAGCCTGGGCCTGACTGTCTACGCCGACTGCCTGGCTGGCA
CGTACAGTGGGGGCAACAAGCGGAAACTCTCCACAGCCATCGCACTCATTGGCTGCCCACCGCTGGTGCTGCTGGATGAGCCCACCACAG
GGATGGACCCCCAGGCACGCCGCATGCTGTGGAACGTCATCGTGAGCATCATCAGAGAAGGGAGGGCTGTGGTCCTCACATCCCACAGCA
TGGAAGAATGTGAGGCACTGTGTACCCGGCTGGCCATCATGGTAAAGGGCGCCTTTCGATGTATGGGCACCATTCAGCATCTCAAGTCCA
AATTTGGAGATGGCTATATCGTCACAATGAAGATCAAATCCCCGAAGGACGACCTGCTTCCTGACCTGAACCCTGTGGAGCAGTTCTTCC
AGGGGAACTTCCCAGGCAGTGTGCAGAGGGAGAGGCACTACAACATGCTCCAGTTCCAGGTCTCCTCCTCCTCCCTGGCGAGGATCTTCC
AGCTCCTCCTCTCCCACAAGGACAGCCTGCTCATCGAGGAGTACTCAGTCACACAGACCACACTGGACCAGGTGTTTGTAAATTTTGCTA
AACAGCAGACTGAAAGTCATGACCTCCCTCTGCACCCTCGAGCTGCTGGAGCCAGTCGACAAGCCCAGGACTGATCTTTCACACCGCTCG
TTCCTGCAGCCAGAAAGGAACTCTGGGCAGCTGGAGGCGCAGGAGCCTGTGCCCATATGGTCATCCAAATGGACTGGCCAGCGTAAATGA
CCCCACTGCAGCAGAAAACAAACACACGAGGAGCATGCAGCGAATTCAGAAAGAGGTCTTTCAGAAGGAAACCGAAACTGACTTGCTCAC
CTGGAACACCTGATGGTGAAACCAAACAAATACAAAATCCTTCTCCAGACCCCAGAACTAGAAACCCCGGGCCATCCCACTAGCAGCTTT
GGCCTCCATATTGCTCTCATTTCAAGCAGATCTGCTTTTCTGCATGTTTGTCTGTGTGTCTGCGTTGTGTGTGATTTTCATGGAAAAATA

>In-frame_ENST00000370243_ENST00000370225_TCGA-AJ-A3EJ_BCAR3_chr1_94054533_-_ABCA4_chr1_94495187_length(amino acids)=1201AA_start in transcript=68_stop in transcript=3673
MLGGTRAASSRALASPDPLPVGAALPATPPCPARPLFAEAGRGRADARAQSALVEAQGSEEASFSELRIMAAGKFASLPRNMPVNHQFPL
ASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLL
DPTVEYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKI
NRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSL
TMGGVQAREQNLPRGNLLREYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGAGGLPPPQRTQRSTEIL
QDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLETE
DNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLYLI
QERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAY
VALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAM
VVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRLCVGVRPGECFGLLG
VNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTV
YADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMG
TIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLLLSHKDSLLIEEYSVTQTTLD

--------------------------------------------------------------
>In-frame_ENST00000370247_ENST00000370225_TCGA-AJ-A3EJ_BCAR3_chr1_94054533_-_ABCA4_chr1_94495187_length(transcript)=3693nt_BP=823nt
AGACTAGCCTGGGAGAAGGAGCCGACTCACTCCCCCGGCTGCCGACTTCCCTGACTTCTGGGCAGAAACAGCACAGCTGCTGTGGTGGGC
TAGGGCTTTAACGTCCGAAGCCCCCTTTCTTTTAACCCTAAAGAAAGTGTGTGGTCCCCGGGACTGAAGACCGAAAGATGCCTAAGGAAT
GCAGTGCTTTCCACGCCCTCTCAGCAGCTCTGTGCTGCTTCTATCACCGCAAGTCTTTCATTGGAGTCAAGTTCTCCAAGGAGAGGCACA
TCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACCTGCGCAGCCATGCCTGGTACC
ACGGCCGCATCCCCCGACAGGTGTCTGAAAACCTTGTGCAGCGAGATGGTGACTTCCTAGTTCGTGACTCTCTGTCCAGCCCTGGGAACT
TTGTCCTGACCTGTCAGTGGAAGAACCTCGCTCAGCACTTCAAAATCAACCGGACAGTTCTGCGACTCAGCGAGGCCTACAGCCGCGTGC
AGTACCAGTTCGAGATGGAGAGCTTCGACTCCATCCCCGGCCTGGTGCGCTGCTACGTGGGCAACCGCCGGCCCATCTCCCAGCAGAGTG
GCGCCATCATCTTCCAGCCCATCAACAGGACGGTGCCTCTGCGGTGCCTGGAGGAGCATTATGGCACCTCCCCAGGCCAGGCCCGGGAGG
GCAGCCTCACCAAGGGAAGGCCGGATGTGGCCAAGAGGCTGAGCCTCACCATGGGTGGCGTCCAGGCCCGAGAGCAGAATTTGCCCAGGG
GAAACCTCCTCAGGGAGTACCCCTGTGGCAACTCAACACCCTGGAAGACTCCTTCTGTGTCCCCAAACATCACCCAGCTGTTCCAGAAGC
AGAAATGGACACAGGTCAACCCTTCACCATCCTGCAGGTGCAGCACCAGGGAGAAGCTCACCATGCTGCCAGAGTGCCCCGAGGGTGCCG
GGGGCCTCCCGCCCCCCCAGAGAACACAGCGCAGCACGGAAATTCTACAAGACCTGACGGACAGGAACATCTCCGACTTCTTGGTAAAAA
CGTATCCTGCTCTTATAAGAAGCAGCTTAAAGAGCAAATTCTGGGTCAATGAACAGAGGTATGGAGGAATTTCCATTGGAGGAAAGCTCC
CAGTCGTCCCCATCACGGGGGAAGCACTTGTTGGGTTTTTAAGCGACCTTGGCCGGATCATGAATGTGAGCGGGGGCCCTATCACTAGAG
AGGCCTCTAAAGAAATACCTGATTTCCTTAAACATCTAGAAACTGAAGACAACATTAAGGTGTGGTTTAATAACAAAGGCTGGCATGCCC
TGGTCAGCTTTCTCAATGTGGCCCACAACGCCATCTTACGGGCCAGCCTGCCTAAGGACAGGAGCCCCGAGGAGTATGGAATCACCGTCA
TTAGCCAACCCCTGAACCTGACCAAGGAGCAGCTCTCAGAGATTACAGTGCTGACCACTTCAGTGGATGCTGTGGTTGCCATCTGCGTGA
TTTTCTCCATGTCCTTCGTCCCAGCCAGCTTTGTCCTTTATTTGATCCAGGAGCGGGTGAACAAATCCAAGCACCTCCAGTTTATCAGTG
GAGTGAGCCCCACCACCTACTGGGTGACCAACTTCCTCTGGGACATCATGAATTATTCCGTGAGTGCTGGGCTGGTGGTGGGCATCTTCA
TCGGGTTTCAGAAGAAAGCCTACACTTCTCCAGAAAACCTTCCTGCCCTTGTGGCACTGCTCCTGCTGTATGGATGGGCGGTCATTCCCA
TGATGTACCCAGCATCCTTCCTGTTTGATGTCCCCAGCACAGCCTATGTGGCTTTATCTTGTGCTAATCTGTTCATCGGCATCAACAGCA
GTGCTATTACCTTCATCTTGGAATTATTTGAGAATAACCGGACGCTGCTCAGGTTCAACGCCGTGCTGAGGAAGCTGCTCATTGTCTTCC
CCCACTTCTGCCTGGGCCGGGGCCTCATTGACCTTGCACTGAGCCAGGCTGTGACAGATGTCTATGCCCGGTTTGGTGAGGAGCACTCTG
CAAATCCGTTCCACTGGGACCTGATTGGGAAGAACCTGTTTGCCATGGTGGTGGAAGGGGTGGTGTACTTCCTCCTGACCCTGCTGGTCC
AGCGCCACTTCTTCCTCTCCCAATGGATTGCCGAGCCCACTAAGGAGCCCATTGTTGATGAAGATGATGATGTGGCTGAAGAAAGACAAA
GAATTATTACTGGTGGAAATAAAACTGACATCTTAAGGCTACATGAACTAACCAAGATTTATCCAGGCACCTCCAGCCCAGCAGTGGACA
GGCTGTGTGTCGGAGTTCGCCCTGGAGAGTGCTTTGGCCTCCTGGGAGTGAATGGTGCCGGCAAAACAACCACATTCAAGATGCTCACTG
GGGACACCACAGTGACCTCAGGGGATGCCACCGTAGCAGGCAAGAGTATTTTAACCAATATTTCTGAAGTCCATCAAAATATGGGCTACT
GTCCTCAGTTTGATGCAATTGATGAGCTGCTCACAGGACGAGAACATCTTTACCTTTATGCCCGGCTTCGAGGTGTACCAGCAGAAGAAA
TCGAAAAGGTTGCAAACTGGAGTATTAAGAGCCTGGGCCTGACTGTCTACGCCGACTGCCTGGCTGGCACGTACAGTGGGGGCAACAAGC
GGAAACTCTCCACAGCCATCGCACTCATTGGCTGCCCACCGCTGGTGCTGCTGGATGAGCCCACCACAGGGATGGACCCCCAGGCACGCC
GCATGCTGTGGAACGTCATCGTGAGCATCATCAGAGAAGGGAGGGCTGTGGTCCTCACATCCCACAGCATGGAAGAATGTGAGGCACTGT
GTACCCGGCTGGCCATCATGGTAAAGGGCGCCTTTCGATGTATGGGCACCATTCAGCATCTCAAGTCCAAATTTGGAGATGGCTATATCG
TCACAATGAAGATCAAATCCCCGAAGGACGACCTGCTTCCTGACCTGAACCCTGTGGAGCAGTTCTTCCAGGGGAACTTCCCAGGCAGTG
TGCAGAGGGAGAGGCACTACAACATGCTCCAGTTCCAGGTCTCCTCCTCCTCCCTGGCGAGGATCTTCCAGCTCCTCCTCTCCCACAAGG
ACAGCCTGCTCATCGAGGAGTACTCAGTCACACAGACCACACTGGACCAGGTGTTTGTAAATTTTGCTAAACAGCAGACTGAAAGTCATG
ACCTCCCTCTGCACCCTCGAGCTGCTGGAGCCAGTCGACAAGCCCAGGACTGATCTTTCACACCGCTCGTTCCTGCAGCCAGAAAGGAAC
TCTGGGCAGCTGGAGGCGCAGGAGCCTGTGCCCATATGGTCATCCAAATGGACTGGCCAGCGTAAATGACCCCACTGCAGCAGAAAACAA
ACACACGAGGAGCATGCAGCGAATTCAGAAAGAGGTCTTTCAGAAGGAAACCGAAACTGACTTGCTCACCTGGAACACCTGATGGTGAAA
CCAAACAAATACAAAATCCTTCTCCAGACCCCAGAACTAGAAACCCCGGGCCATCCCACTAGCAGCTTTGGCCTCCATATTGCTCTCATT
TCAAGCAGATCTGCTTTTCTGCATGTTTGTCTGTGTGTCTGCGTTGTGTGTGATTTTCATGGAAAAATAAAATGCAAATGCACTCATCAC

>In-frame_ENST00000370247_ENST00000370225_TCGA-AJ-A3EJ_BCAR3_chr1_94054533_-_ABCA4_chr1_94495187_length(amino acids)=1041AA_start in transcript=167_stop in transcript=3292
MPKECSAFHALSAALCCFYHRKSFIGVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLS
SPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPG
QAREGSLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLREYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPEC
PEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGG
PITREASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVV
AICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGW
AVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFG
EEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSS
PAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGV
PAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEE
CEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLL

--------------------------------------------------------------
>In-frame_ENST00000370247_ENST00000370225_TCGA-ZS-A9CF-02A_BCAR3_chr1_94079404_-_ABCA4_chr1_94505683_length(transcript)=3951nt_BP=251nt
AGACTAGCCTGGGAGAAGGAGCCGACTCACTCCCCCGGCTGCCGACTTCCCTGACTTCTGGGCAGAAACAGCACAGCTGCTGTGGTGGGC
TAGGGCTTTAACGTCCGAAGCCCCCTTTCTTTTAACCCTAAAGAAAGTGTGTGGTCCCCGGGACTGAAGACCGAAAGATGCCTAAGGAAT
GCAGTGCTTTCCACGCCCTCTCAGCAGCTCTGTGCTGCTTCTATCACCGCAAGTCTTTCATTGGAGTCAAGGGGACCTGCAGCTGCTCGT
CTAAGGGTTTCTCCACCACGTGTCCAGCCCACGTCGATGACCTAACTCCAGAACAAGTCCTGGATGGGGATGTAAATGAGCTGATGGATG
TAGTTCTCCACCATGTTCCAGAGGCAAAGCTGGTGGAGTGCATTGGTCAAGAACTTATCTTCCTTCTTCCAAATAAGAACTTCAAGCACA
GAGCATATGCCAGCCTTTTCAGAGAGCTGGAGGAGACGCTGGCTGACCTTGGTCTCAGCAGTTTTGGAATTTCTGACACTCCCCTGGAAG
AGATTTTTCTGAAGGTCACGGAGGATTCTGATTCAGGACCTCTGTTTGCGGGTGGCGCTCAGCAGAAAAGAGAAAACGTCAACCCCCGAC
ACCCCTGCTTGGGTCCCAGAGAGAAGGCTGGACAGACACCCCAGGACTCCAATGTCTGCTCCCCAGGGGCGCCGGCTGCTCACCCAGAGG
GCCAGCCTCCCCCAGAGCCAGAGTGCCCAGGCCCGCAGCTCAACACGGGGACACAGCTGGTCCTCCAGCATGTGCAGGCGCTGCTGGTCA
AGAGATTCCAACACACCATCCGCAGCCACAAGGACTTCCTGGCGCAGATCGTGCTCCCGGCTACCTTTGTGTTTTTGGCTCTGATGCTTT
CTATTGTTATCCCTCCTTTTGGCGAATACCCCGCTTTGACCCTTCACCCCTGGATATATGGGCAGCAGTACACCTTCTTCAGCATGGATG
AACCAGGCAGTGAGCAGTTCACGGTACTTGCAGACGTCCTCCTGAATAAGCCAGGCTTTGGCAACCGCTGCCTGAAGGAAGGGTGGCTTC
CGGAGTACCCCTGTGGCAACTCAACACCCTGGAAGACTCCTTCTGTGTCCCCAAACATCACCCAGCTGTTCCAGAAGCAGAAATGGACAC
AGGTCAACCCTTCACCATCCTGCAGGTGCAGCACCAGGGAGAAGCTCACCATGCTGCCAGAGTGCCCCGAGGGTGCCGGGGGCCTCCCGC
CCCCCCAGAGAACACAGCGCAGCACGGAAATTCTACAAGACCTGACGGACAGGAACATCTCCGACTTCTTGGTAAAAACGTATCCTGCTC
TTATAAGAAGCAGCTTAAAGAGCAAATTCTGGGTCAATGAACAGAGGTATGGAGGAATTTCCATTGGAGGAAAGCTCCCAGTCGTCCCCA
TCACGGGGGAAGCACTTGTTGGGTTTTTAAGCGACCTTGGCCGGATCATGAATGTGAGCGGGGGCCCTATCACTAGAGAGGCCTCTAAAG
AAATACCTGATTTCCTTAAACATCTAGAAACTGAAGACAACATTAAGGTGTGGTTTAATAACAAAGGCTGGCATGCCCTGGTCAGCTTTC
TCAATGTGGCCCACAACGCCATCTTACGGGCCAGCCTGCCTAAGGACAGGAGCCCCGAGGAGTATGGAATCACCGTCATTAGCCAACCCC
TGAACCTGACCAAGGAGCAGCTCTCAGAGATTACAGTGCTGACCACTTCAGTGGATGCTGTGGTTGCCATCTGCGTGATTTTCTCCATGT
CCTTCGTCCCAGCCAGCTTTGTCCTTTATTTGATCCAGGAGCGGGTGAACAAATCCAAGCACCTCCAGTTTATCAGTGGAGTGAGCCCCA
CCACCTACTGGGTGACCAACTTCCTCTGGGACATCATGAATTATTCCGTGAGTGCTGGGCTGGTGGTGGGCATCTTCATCGGGTTTCAGA
AGAAAGCCTACACTTCTCCAGAAAACCTTCCTGCCCTTGTGGCACTGCTCCTGCTGTATGGATGGGCGGTCATTCCCATGATGTACCCAG
CATCCTTCCTGTTTGATGTCCCCAGCACAGCCTATGTGGCTTTATCTTGTGCTAATCTGTTCATCGGCATCAACAGCAGTGCTATTACCT
TCATCTTGGAATTATTTGAGAATAACCGGACGCTGCTCAGGTTCAACGCCGTGCTGAGGAAGCTGCTCATTGTCTTCCCCCACTTCTGCC
TGGGCCGGGGCCTCATTGACCTTGCACTGAGCCAGGCTGTGACAGATGTCTATGCCCGGTTTGGTGAGGAGCACTCTGCAAATCCGTTCC
ACTGGGACCTGATTGGGAAGAACCTGTTTGCCATGGTGGTGGAAGGGGTGGTGTACTTCCTCCTGACCCTGCTGGTCCAGCGCCACTTCT
TCCTCTCCCAATGGATTGCCGAGCCCACTAAGGAGCCCATTGTTGATGAAGATGATGATGTGGCTGAAGAAAGACAAAGAATTATTACTG
GTGGAAATAAAACTGACATCTTAAGGCTACATGAACTAACCAAGATTTATCCAGGCACCTCCAGCCCAGCAGTGGACAGGCTGTGTGTCG
GAGTTCGCCCTGGAGAGTGCTTTGGCCTCCTGGGAGTGAATGGTGCCGGCAAAACAACCACATTCAAGATGCTCACTGGGGACACCACAG
TGACCTCAGGGGATGCCACCGTAGCAGGCAAGAGTATTTTAACCAATATTTCTGAAGTCCATCAAAATATGGGCTACTGTCCTCAGTTTG
ATGCAATTGATGAGCTGCTCACAGGACGAGAACATCTTTACCTTTATGCCCGGCTTCGAGGTGTACCAGCAGAAGAAATCGAAAAGGTTG
CAAACTGGAGTATTAAGAGCCTGGGCCTGACTGTCTACGCCGACTGCCTGGCTGGCACGTACAGTGGGGGCAACAAGCGGAAACTCTCCA
CAGCCATCGCACTCATTGGCTGCCCACCGCTGGTGCTGCTGGATGAGCCCACCACAGGGATGGACCCCCAGGCACGCCGCATGCTGTGGA
ACGTCATCGTGAGCATCATCAGAGAAGGGAGGGCTGTGGTCCTCACATCCCACAGCATGGAAGAATGTGAGGCACTGTGTACCCGGCTGG
CCATCATGGTAAAGGGCGCCTTTCGATGTATGGGCACCATTCAGCATCTCAAGTCCAAATTTGGAGATGGCTATATCGTCACAATGAAGA
TCAAATCCCCGAAGGACGACCTGCTTCCTGACCTGAACCCTGTGGAGCAGTTCTTCCAGGGGAACTTCCCAGGCAGTGTGCAGAGGGAGA
GGCACTACAACATGCTCCAGTTCCAGGTCTCCTCCTCCTCCCTGGCGAGGATCTTCCAGCTCCTCCTCTCCCACAAGGACAGCCTGCTCA
TCGAGGAGTACTCAGTCACACAGACCACACTGGACCAGGTGTTTGTAAATTTTGCTAAACAGCAGACTGAAAGTCATGACCTCCCTCTGC
ACCCTCGAGCTGCTGGAGCCAGTCGACAAGCCCAGGACTGATCTTTCACACCGCTCGTTCCTGCAGCCAGAAAGGAACTCTGGGCAGCTG
GAGGCGCAGGAGCCTGTGCCCATATGGTCATCCAAATGGACTGGCCAGCGTAAATGACCCCACTGCAGCAGAAAACAAACACACGAGGAG
CATGCAGCGAATTCAGAAAGAGGTCTTTCAGAAGGAAACCGAAACTGACTTGCTCACCTGGAACACCTGATGGTGAAACCAAACAAATAC
AAAATCCTTCTCCAGACCCCAGAACTAGAAACCCCGGGCCATCCCACTAGCAGCTTTGGCCTCCATATTGCTCTCATTTCAAGCAGATCT

>In-frame_ENST00000370247_ENST00000370225_TCGA-ZS-A9CF-02A_BCAR3_chr1_94079404_-_ABCA4_chr1_94505683_length(amino acids)=1127AA_start in transcript=167_stop in transcript=3550
MPKECSAFHALSAALCCFYHRKSFIGVKGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNK
NFKHRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSDSGPLFAGGAQQKRENVNPRHPCLGPREKAGQTPQDSNVCSPGAPA
AHPEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTF
FSMDEPGSEQFTVLADVLLNKPGFGNRCLKEGWLPEYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGA
GGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITR
EASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICV
IFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIP
MMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHS
ANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVD
RLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEE
IEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEAL
CTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLLLSHK

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Fusion Gene PPI Analysis for BCAR3-ABCA4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BCAR3-ABCA4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BCAR3-ABCA4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBCAR3C0006142Malignant neoplasm of breast1CTD_human
HgeneBCAR3C0013146Drug abuse1CTD_human
HgeneBCAR3C0013170Drug habituation1CTD_human
HgeneBCAR3C0013222Drug Use Disorders1CTD_human
HgeneBCAR3C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneBCAR3C0038580Substance Dependence1CTD_human
HgeneBCAR3C0038586Substance Use Disorders1CTD_human
HgeneBCAR3C0236969Substance-Related Disorders1CTD_human
HgeneBCAR3C0678222Breast Carcinoma1CTD_human
HgeneBCAR3C0740858Substance abuse problem1CTD_human
HgeneBCAR3C1257931Mammary Neoplasms, Human1CTD_human
HgeneBCAR3C1458155Mammary Neoplasms1CTD_human
HgeneBCAR3C1510472Drug Dependence1CTD_human
HgeneBCAR3C4316881Prescription Drug Abuse1CTD_human
HgeneBCAR3C4704874Mammary Carcinoma, Human1CTD_human
TgeneABCA4C1855465STARGARDT DISEASE 1 (disorder)21CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneABCA4C1858806CONE-ROD DYSTROPHY 3 (disorder)3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneABCA4C3489532Cone-Rod Dystrophy 23ORPHANET
TgeneABCA4C3495438Macular Degeneration, Age-Related, 22CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneABCA4C0008924Cleft upper lip1CTD_human
TgeneABCA4C0009402Colorectal Carcinoma1CTD_human
TgeneABCA4C0009404Colorectal Neoplasms1CTD_human
TgeneABCA4C0035334Retinitis Pigmentosa1CTD_human;GENOMICS_ENGLAND
TgeneABCA4C0242383Age related macular degeneration1CTD_human;GENOMICS_ENGLAND
TgeneABCA4C0271093Stargardt's disease1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneABCA4C0339539Familial Exudative Vitreoretinopathy1CTD_human