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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BCAR3-SH2D3C (FusionGDB2 ID:9245)

Fusion Gene Summary for BCAR3-SH2D3C

check button Fusion gene summary
Fusion gene informationFusion gene name: BCAR3-SH2D3C
Fusion gene ID: 9245
HgeneTgene
Gene symbol

BCAR3

SH2D3C

Gene ID

8412

10044

Gene nameBCAR3 adaptor protein, NSP family memberSH2 domain containing 3C
SynonymsAND-34|NSP2|SH2D3BCHAT|NSP3|PRO34088|SHEP1
Cytomap

1p22.1

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionbreast cancer anti-estrogen resistance protein 3BCAR3, NSP family adaptor proteinSH2 domain-containing protein 3Bbreast cancer anti-estrogen resistance 3breast cancer antiestrogen resistance 3 proteindJ1033H22.2 (breast cancer anti-estrogen resistancSH2 domain-containing protein 3CSH2 domain-containing Eph receptor-binding protein 1novel SH2-containing protein 3
Modification date2020031320200313
UniProtAcc

O75815

.
Ensembl transtripts involved in fusion geneENST00000260502, ENST00000370244, 
ENST00000370243, ENST00000370247, 
ENST00000539242, ENST00000466632, 
ENST00000373277, ENST00000373274, 
ENST00000420366, ENST00000429553, 
ENST00000373276, ENST00000314830, 
ENST00000471939, 
Fusion gene scores* DoF score11 X 12 X 9=11885 X 5 X 4=100
# samples 125
** MAII scorelog2(12/1188*10)=-3.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BCAR3 [Title/Abstract] AND SH2D3C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBCAR3(94057822)-SH2D3C(130511944), # samples:1
Anticipated loss of major functional domain due to fusion event.BCAR3-SH2D3C seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
BCAR3-SH2D3C seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across BCAR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SH2D3C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-CJ-4870-01ABCAR3chr1

94057822

-SH2D3Cchr9

130511944

-


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Fusion Gene ORF analysis for BCAR3-SH2D3C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000260502ENST00000373277BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
Frame-shiftENST00000260502ENST00000373274BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
Frame-shiftENST00000260502ENST00000420366BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000260502ENST00000429553BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000260502ENST00000373276BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000260502ENST00000314830BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-intronENST00000260502ENST00000471939BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
Frame-shiftENST00000370244ENST00000373277BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
Frame-shiftENST00000370244ENST00000373274BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
Frame-shiftENST00000370244ENST00000420366BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000370244ENST00000429553BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000370244ENST00000373276BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000370244ENST00000314830BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-intronENST00000370244ENST00000471939BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
In-frameENST00000370243ENST00000373277BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
In-frameENST00000370243ENST00000373274BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
In-frameENST00000370243ENST00000420366BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000370243ENST00000429553BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000370243ENST00000373276BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000370243ENST00000314830BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-intronENST00000370243ENST00000471939BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
In-frameENST00000370247ENST00000373277BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
In-frameENST00000370247ENST00000373274BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
In-frameENST00000370247ENST00000420366BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000370247ENST00000429553BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000370247ENST00000373276BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-5UTRENST00000370247ENST00000314830BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
5CDS-intronENST00000370247ENST00000471939BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-3CDSENST00000539242ENST00000373277BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-3CDSENST00000539242ENST00000373274BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-3CDSENST00000539242ENST00000420366BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-5UTRENST00000539242ENST00000429553BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-5UTRENST00000539242ENST00000373276BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-5UTRENST00000539242ENST00000314830BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-intronENST00000539242ENST00000471939BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-3CDSENST00000466632ENST00000373277BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-3CDSENST00000466632ENST00000373274BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-3CDSENST00000466632ENST00000420366BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-5UTRENST00000466632ENST00000429553BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-5UTRENST00000466632ENST00000373276BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-5UTRENST00000466632ENST00000314830BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-
intron-intronENST00000466632ENST00000471939BCAR3chr1

94057822

-SH2D3Cchr9

130511944

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370243BCAR3chr194057822-ENST00000373277SH2D3Cchr9130511944-3089761682659863
ENST00000370243BCAR3chr194057822-ENST00000373274SH2D3Cchr9130511944-3088761682659863
ENST00000370243BCAR3chr194057822-ENST00000420366SH2D3Cchr9130511944-3088761682659863
ENST00000370247BCAR3chr194057822-ENST00000373277SH2D3Cchr9130511944-27083801672278703
ENST00000370247BCAR3chr194057822-ENST00000373274SH2D3Cchr9130511944-27073801672278703
ENST00000370247BCAR3chr194057822-ENST00000420366SH2D3Cchr9130511944-27073801672278703

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370243ENST00000373277BCAR3chr194057822-SH2D3Cchr9130511944-0.0340954250.9659046
ENST00000370243ENST00000373274BCAR3chr194057822-SH2D3Cchr9130511944-0.034575630.96542436
ENST00000370243ENST00000420366BCAR3chr194057822-SH2D3Cchr9130511944-0.034575630.96542436
ENST00000370247ENST00000373277BCAR3chr194057822-SH2D3Cchr9130511944-0.0331054780.96689457
ENST00000370247ENST00000373274BCAR3chr194057822-SH2D3Cchr9130511944-0.0338466540.9661533
ENST00000370247ENST00000420366BCAR3chr194057822-SH2D3Cchr9130511944-0.0338466540.9661533

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Fusion Genomic Features for BCAR3-SH2D3C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BCAR3-SH2D3C


check button Go to

FGviewer for the breakpoints of chr1:94057822-chr9:130511944

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BCAR3

O75815

.
FUNCTION: Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:Q9QZK2, ECO:0000269|PubMed:18722344, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:24216110}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSH2D3Cchr1:94057822chr9:130511944ENST00000314830312586_854228.0861.0DomainRas-GEF
TgeneSH2D3Cchr1:94057822chr9:130511944ENST00000373274110220_31968.0701.0DomainSH2
TgeneSH2D3Cchr1:94057822chr9:130511944ENST00000373274110586_85468.0701.0DomainRas-GEF
TgeneSH2D3Cchr1:94057822chr9:130511944ENST00000373277211220_31971.0704.0DomainSH2
TgeneSH2D3Cchr1:94057822chr9:130511944ENST00000373277211586_85471.0704.0DomainRas-GEF
TgeneSH2D3Cchr1:94057822chr9:130511944ENST00000420366110220_31970.0703.0DomainSH2
TgeneSH2D3Cchr1:94057822chr9:130511944ENST00000420366110586_85470.0703.0DomainRas-GEF
TgeneSH2D3Cchr1:94057822chr9:130511944ENST00000429553211220_3190507.0DomainSH2
TgeneSH2D3Cchr1:94057822chr9:130511944ENST00000429553211586_8540507.0DomainRas-GEF

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBCAR3chr1:94057822chr9:130511944ENST00000260502-412479_482162.0826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94057822chr9:130511944ENST00000370243-412479_482162.0826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94057822chr9:130511944ENST00000370244-614479_482162.0826.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94057822chr9:130511944ENST00000370247-210479_48271.0735.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94057822chr9:130511944ENST00000539242-18479_4820502.0Compositional biasNote=Poly-Asp
HgeneBCAR3chr1:94057822chr9:130511944ENST00000260502-412154_253162.0826.0DomainSH2
HgeneBCAR3chr1:94057822chr9:130511944ENST00000260502-412548_818162.0826.0DomainRas-GEF
HgeneBCAR3chr1:94057822chr9:130511944ENST00000370243-412154_253162.0826.0DomainSH2
HgeneBCAR3chr1:94057822chr9:130511944ENST00000370243-412548_818162.0826.0DomainRas-GEF
HgeneBCAR3chr1:94057822chr9:130511944ENST00000370244-614154_253162.0826.0DomainSH2
HgeneBCAR3chr1:94057822chr9:130511944ENST00000370244-614548_818162.0826.0DomainRas-GEF
HgeneBCAR3chr1:94057822chr9:130511944ENST00000370247-210154_25371.0735.0DomainSH2
HgeneBCAR3chr1:94057822chr9:130511944ENST00000370247-210548_81871.0735.0DomainRas-GEF
HgeneBCAR3chr1:94057822chr9:130511944ENST00000539242-18154_2530502.0DomainSH2
HgeneBCAR3chr1:94057822chr9:130511944ENST00000539242-18548_8180502.0DomainRas-GEF
TgeneSH2D3Cchr1:94057822chr9:130511944ENST00000314830312220_319228.0861.0DomainSH2


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Fusion Gene Sequence for BCAR3-SH2D3C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000370243_ENST00000373277_TCGA-CJ-4870-01A_BCAR3_chr1_94057822_-_SH2D3C_chr9_130511944_length(transcript)=3089nt_BP=761nt
GAGCGCGCTGGGACTCCCCGAGACGTGGCCCACGGCGGGGAGCGCTCAGCGATTGGCGGCCAGGCATCTTGCTCGGTGGCACTCGAGCGG
CATCTTCCCGGGCGCTGGCCTCGCCCGACCCCCTGCCCGTCGGAGCTGCTCTGCCGGCCACCCCGCCCTGTCCCGCCCGTCCCCTCTTCG
CAGAAGCCGGCCGGGGTCGGGCAGATGCGAGGGCCCAGAGCGCTCTGGTGGAAGCCCAAGGCTCCGAGGAGGCGAGTTTCTCCGAGTTGA
GAATTATGGCTGCAGGAAAATTTGCAAGCCTTCCCAGAAACATGCCGGTGAATCACCAGTTCCCCCTGGCCTCATCCATGGACCTTCTGA
GCAGCAGGTCCCCTCTCGCTGAGCATCGCCCAGATGCCTATCAAGATGTGTCTATACATGGCACCCTTCCACGGAAGAAAAAAGGTCCTC
CTCCCATAAGGTCCTGTGATGACTTCAGTCACATGGGCACCCTCCCCCACTCCAAATCCCCACGGCAGAACTCGCCTGTGACCCAGGATG
GCATCCAGGAGAGCCCATGGCAGGACCGGCACGGCGAAACCTTCACCTTCAGGGATCCACATCTTCTGGACCCAACTGTGGAATATGTGA
AGTTCTCCAAGGAGAGGCACATCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACC
TGCGCAGCCATGCCTGGTACCACGGCCGCATCCCCCGACAGGTCTCGGAGACCTTGGTACAACGCAACGGCGACTTCCTCATCCGGGACT
CACTCACCAGCCTGGGCGACTATGTGCTCACGTGCCGCTGGCGCAACCAGGCCTTGCACTTCAAGATCAACAAGGTGGTGGTGAAGGCAG
GCGAGAGCTACACACACATCCAGTACCTGTTTGAGCAGGAGAGCTTTGACCACGTGCCCGCCCTCGTGCGCTATCATGTGGGCAGCCGCA
AGGCTGTGTCAGAGCAGAGTGGTGCCATCATCTACTGCCCGGTGAACCGCACCTTCCCACTGCGCTACCTCGAGGCCAGCTATGGCCTGG
GACAGGGGAGTAGCAAGCCTGCTAGCCCCGTCAGCCCCTCAGGCCCCAAGGGCAGCCACATGAAGCGGCGCAGCGTCACCATGACCGATG
GGCTCACTGCTGACAAGGTCACCCGCAGCGATGGCTGCCCCACCAGTACGTCGCTGCCCCGCCCTCGGGACTCCATCCGCAGCTGTGCCC
TCAGCATGGACCAGATCCCAGACCTGCACTCACCCATGTCGCCCATCTCCGAGAGCCCTAGCTCCCCTGCCTACAGCACTGTAACCCGTG
TCCATGCCGCCCCTGCAGCCCCTTCTGCCACAGCATTGCCTGCCTCCCCTGTCGCCCGCCGTTCCAGTGAGCCCCAGCTGTGTCCCGGAA
GTGCCCCAAAGACCCATGGGGAGTCAGACAAGGGCCCCCACACCAGCCCCTCCCACACCCTTGGCAAGGCCTCCCCGTCACCATCACTCA
GCAGCTACAGTGACCCGGACTCTGGCCACTACTGCCAGCTCCAGCCTCCCGTGCGTGGCAGCCGAGAGTGGGCAGCGACTGAGACCTCCA
GCCAGCAGGCCAGGAGCTATGGGGAGAGGCTAAAGGAACTGTCAGAAAATGGGGCCCCTGAAGGGGACTGGGGCAAGACCTTCACAGTCC
CCATCGTGGAAGTCACTTCTTCCTTCAACCCGGCCACCTTCCAGTCACTACTGATCCCCAGGGATAACCGGCCACTGGAGGTGGGCCTTC
TGCGCAAGGTCAAGGAGCTGCTGGCAGAAGTGGATGCCCGGACGCTGGCCCGGCATGTCACCAAGGTGGACTGCCTGGTTGCTAGGATAC
TGGGCGTTACCAAGGAGATGCAGACCCTAATGGGAGTCCGCTGGGGCATGGAACTGCTCACCCTCCCCCATGGCCGGCAGCTACGCCTAG
ACCTGCTGGAAAGGTTCCACACCATGTCCATCATGCTGGCCGTGGACATCCTGGGCTGCACCGGCTCTGCGGAGGAGCGGGCAGCGCTGC
TGCACAAGACCATTCAGCTGGCGGCCGAGCTGCGGGGGACTATGGGCAACATGTTCAGCTTCGCGGCGGTCATGGGTGCCCTGGACATGG
CCCAGATTTCTCGGCTGGAGCAGACATGGGTGACCCTGCGGCAGCGACACACAGAGGGTGCCATCCTGTACGAGAAGAAGCTCAAGCCTT
TTCTCAAGAGCCTCAACGAGGGCAAAGAAGGCCCGCCGCTGAGCAACACCACGTTTCCTCATGTGCTGCCCCTCATCACCCTGCTGGAGT
GTGACTCGGCCCCACCAGAGGGCCCTGAGCCCTGGGGCAGCACGGAGCACGGCGTGGAGGTGGTGCTGGCTCACCTGGAGGCCGCCCGCA
CAGTGGCACACCACGGAGGCCTGTACCACACCAATGCTGAAGTCAAGCTGCAGGGGTTCCAGGCCCGGCCGGAGCTCCTGGAGGTGTTCA
GCACGGAGTTCCAGATGCGCCTTCTCTGGGGCAGTCAGGGTGCCAGCAGCAGCCAGGCCCGGCGCTATGAGAAGTTCGACAAGGTCCTCA
CTGCCCTGTCCCACAAGCTGGAACCTGCTGTCCGCTCCAGCGAGCTGTGACCCCAGGGACATTTCCCCTCTGCAGCTGCGGACAGCGTCA
GGGGCAGAGGGGCACACAACTTTCCCCAGAGCACCCCAAGGACACTGTGATCAACCCGAGAATGTTCTGGGTTCAACTCAAGCATCTCCC
TTGCACCTCCAGGGTCCTGCGTGGACTCTGGGTTCCATCCCACCTGCTACATGCTCACCAGGTCTCCATTGAGGAAGAACAGGAACGCCG
GTTCCCCCACCAGCTTTTGCTGCTCCCCTTCCTGCTGGGGTTCCCTGTTTTCGAGCCATGGGAGGCAGGCTGCTCACGCCTCCTCACTCT
CTGTCTGTCCCTCACCAACACCAAGGCCTCCATCTCACTGTAAATAAGTCTCTGTTCTGTAAATAGATGTACAGAAGCCATGTTATTTCT

>In-frame_ENST00000370243_ENST00000373277_TCGA-CJ-4870-01A_BCAR3_chr1_94057822_-_SH2D3C_chr9_130511944_length(amino acids)=863AA_start in transcript=68_stop in transcript=2659
MLGGTRAASSRALASPDPLPVGAALPATPPCPARPLFAEAGRGRADARAQSALVEAQGSEEASFSELRIMAAGKFASLPRNMPVNHQFPL
ASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLL
DPTVEYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKI
NKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKR
RSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSS
EPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGD
WGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLP
HGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAIL
YEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQAR

--------------------------------------------------------------
>In-frame_ENST00000370243_ENST00000373274_TCGA-CJ-4870-01A_BCAR3_chr1_94057822_-_SH2D3C_chr9_130511944_length(transcript)=3088nt_BP=761nt
GAGCGCGCTGGGACTCCCCGAGACGTGGCCCACGGCGGGGAGCGCTCAGCGATTGGCGGCCAGGCATCTTGCTCGGTGGCACTCGAGCGG
CATCTTCCCGGGCGCTGGCCTCGCCCGACCCCCTGCCCGTCGGAGCTGCTCTGCCGGCCACCCCGCCCTGTCCCGCCCGTCCCCTCTTCG
CAGAAGCCGGCCGGGGTCGGGCAGATGCGAGGGCCCAGAGCGCTCTGGTGGAAGCCCAAGGCTCCGAGGAGGCGAGTTTCTCCGAGTTGA
GAATTATGGCTGCAGGAAAATTTGCAAGCCTTCCCAGAAACATGCCGGTGAATCACCAGTTCCCCCTGGCCTCATCCATGGACCTTCTGA
GCAGCAGGTCCCCTCTCGCTGAGCATCGCCCAGATGCCTATCAAGATGTGTCTATACATGGCACCCTTCCACGGAAGAAAAAAGGTCCTC
CTCCCATAAGGTCCTGTGATGACTTCAGTCACATGGGCACCCTCCCCCACTCCAAATCCCCACGGCAGAACTCGCCTGTGACCCAGGATG
GCATCCAGGAGAGCCCATGGCAGGACCGGCACGGCGAAACCTTCACCTTCAGGGATCCACATCTTCTGGACCCAACTGTGGAATATGTGA
AGTTCTCCAAGGAGAGGCACATCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACC
TGCGCAGCCATGCCTGGTACCACGGCCGCATCCCCCGACAGGTCTCGGAGACCTTGGTACAACGCAACGGCGACTTCCTCATCCGGGACT
CACTCACCAGCCTGGGCGACTATGTGCTCACGTGCCGCTGGCGCAACCAGGCCTTGCACTTCAAGATCAACAAGGTGGTGGTGAAGGCAG
GCGAGAGCTACACACACATCCAGTACCTGTTTGAGCAGGAGAGCTTTGACCACGTGCCCGCCCTCGTGCGCTATCATGTGGGCAGCCGCA
AGGCTGTGTCAGAGCAGAGTGGTGCCATCATCTACTGCCCGGTGAACCGCACCTTCCCACTGCGCTACCTCGAGGCCAGCTATGGCCTGG
GACAGGGGAGTAGCAAGCCTGCTAGCCCCGTCAGCCCCTCAGGCCCCAAGGGCAGCCACATGAAGCGGCGCAGCGTCACCATGACCGATG
GGCTCACTGCTGACAAGGTCACCCGCAGCGATGGCTGCCCCACCAGTACGTCGCTGCCCCGCCCTCGGGACTCCATCCGCAGCTGTGCCC
TCAGCATGGACCAGATCCCAGACCTGCACTCACCCATGTCGCCCATCTCCGAGAGCCCTAGCTCCCCTGCCTACAGCACTGTAACCCGTG
TCCATGCCGCCCCTGCAGCCCCTTCTGCCACAGCATTGCCTGCCTCCCCTGTCGCCCGCCGTTCCAGTGAGCCCCAGCTGTGTCCCGGAA
GTGCCCCAAAGACCCATGGGGAGTCAGACAAGGGCCCCCACACCAGCCCCTCCCACACCCTTGGCAAGGCCTCCCCGTCACCATCACTCA
GCAGCTACAGTGACCCGGACTCTGGCCACTACTGCCAGCTCCAGCCTCCCGTGCGTGGCAGCCGAGAGTGGGCAGCGACTGAGACCTCCA
GCCAGCAGGCCAGGAGCTATGGGGAGAGGCTAAAGGAACTGTCAGAAAATGGGGCCCCTGAAGGGGACTGGGGCAAGACCTTCACAGTCC
CCATCGTGGAAGTCACTTCTTCCTTCAACCCGGCCACCTTCCAGTCACTACTGATCCCCAGGGATAACCGGCCACTGGAGGTGGGCCTTC
TGCGCAAGGTCAAGGAGCTGCTGGCAGAAGTGGATGCCCGGACGCTGGCCCGGCATGTCACCAAGGTGGACTGCCTGGTTGCTAGGATAC
TGGGCGTTACCAAGGAGATGCAGACCCTAATGGGAGTCCGCTGGGGCATGGAACTGCTCACCCTCCCCCATGGCCGGCAGCTACGCCTAG
ACCTGCTGGAAAGGTTCCACACCATGTCCATCATGCTGGCCGTGGACATCCTGGGCTGCACCGGCTCTGCGGAGGAGCGGGCAGCGCTGC
TGCACAAGACCATTCAGCTGGCGGCCGAGCTGCGGGGGACTATGGGCAACATGTTCAGCTTCGCGGCGGTCATGGGTGCCCTGGACATGG
CCCAGATTTCTCGGCTGGAGCAGACATGGGTGACCCTGCGGCAGCGACACACAGAGGGTGCCATCCTGTACGAGAAGAAGCTCAAGCCTT
TTCTCAAGAGCCTCAACGAGGGCAAAGAAGGCCCGCCGCTGAGCAACACCACGTTTCCTCATGTGCTGCCCCTCATCACCCTGCTGGAGT
GTGACTCGGCCCCACCAGAGGGCCCTGAGCCCTGGGGCAGCACGGAGCACGGCGTGGAGGTGGTGCTGGCTCACCTGGAGGCCGCCCGCA
CAGTGGCACACCACGGAGGCCTGTACCACACCAATGCTGAAGTCAAGCTGCAGGGGTTCCAGGCCCGGCCGGAGCTCCTGGAGGTGTTCA
GCACGGAGTTCCAGATGCGCCTTCTCTGGGGCAGTCAGGGTGCCAGCAGCAGCCAGGCCCGGCGCTATGAGAAGTTCGACAAGGTCCTCA
CTGCCCTGTCCCACAAGCTGGAACCTGCTGTCCGCTCCAGCGAGCTGTGACCCCAGGGACATTTCCCCTCTGCAGCTGCGGACAGCGTCA
GGGGCAGAGGGGCACACAACTTTCCCCAGAGCACCCCAAGGACACTGTGATCAACCCGAGAATGTTCTGGGTTCAACTCAAGCATCTCCC
TTGCACCTCCAGGGTCCTGCGTGGACTCTGGGTTCCATCCCACCTGCTACATGCTCACCAGGTCTCCATTGAGGAAGAACAGGAACGCCG
GTTCCCCCACCAGCTTTTGCTGCTCCCCTTCCTGCTGGGGTTCCCTGTTTTCGAGCCATGGGAGGCAGGCTGCTCACGCCTCCTCACTCT
CTGTCTGTCCCTCACCAACACCAAGGCCTCCATCTCACTGTAAATAAGTCTCTGTTCTGTAAATAGATGTACAGAAGCCATGTTATTTCT

>In-frame_ENST00000370243_ENST00000373274_TCGA-CJ-4870-01A_BCAR3_chr1_94057822_-_SH2D3C_chr9_130511944_length(amino acids)=863AA_start in transcript=68_stop in transcript=2659
MLGGTRAASSRALASPDPLPVGAALPATPPCPARPLFAEAGRGRADARAQSALVEAQGSEEASFSELRIMAAGKFASLPRNMPVNHQFPL
ASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLL
DPTVEYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKI
NKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKR
RSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSS
EPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGD
WGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLP
HGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAIL
YEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQAR

--------------------------------------------------------------
>In-frame_ENST00000370243_ENST00000420366_TCGA-CJ-4870-01A_BCAR3_chr1_94057822_-_SH2D3C_chr9_130511944_length(transcript)=3088nt_BP=761nt
GAGCGCGCTGGGACTCCCCGAGACGTGGCCCACGGCGGGGAGCGCTCAGCGATTGGCGGCCAGGCATCTTGCTCGGTGGCACTCGAGCGG
CATCTTCCCGGGCGCTGGCCTCGCCCGACCCCCTGCCCGTCGGAGCTGCTCTGCCGGCCACCCCGCCCTGTCCCGCCCGTCCCCTCTTCG
CAGAAGCCGGCCGGGGTCGGGCAGATGCGAGGGCCCAGAGCGCTCTGGTGGAAGCCCAAGGCTCCGAGGAGGCGAGTTTCTCCGAGTTGA
GAATTATGGCTGCAGGAAAATTTGCAAGCCTTCCCAGAAACATGCCGGTGAATCACCAGTTCCCCCTGGCCTCATCCATGGACCTTCTGA
GCAGCAGGTCCCCTCTCGCTGAGCATCGCCCAGATGCCTATCAAGATGTGTCTATACATGGCACCCTTCCACGGAAGAAAAAAGGTCCTC
CTCCCATAAGGTCCTGTGATGACTTCAGTCACATGGGCACCCTCCCCCACTCCAAATCCCCACGGCAGAACTCGCCTGTGACCCAGGATG
GCATCCAGGAGAGCCCATGGCAGGACCGGCACGGCGAAACCTTCACCTTCAGGGATCCACATCTTCTGGACCCAACTGTGGAATATGTGA
AGTTCTCCAAGGAGAGGCACATCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACC
TGCGCAGCCATGCCTGGTACCACGGCCGCATCCCCCGACAGGTCTCGGAGACCTTGGTACAACGCAACGGCGACTTCCTCATCCGGGACT
CACTCACCAGCCTGGGCGACTATGTGCTCACGTGCCGCTGGCGCAACCAGGCCTTGCACTTCAAGATCAACAAGGTGGTGGTGAAGGCAG
GCGAGAGCTACACACACATCCAGTACCTGTTTGAGCAGGAGAGCTTTGACCACGTGCCCGCCCTCGTGCGCTATCATGTGGGCAGCCGCA
AGGCTGTGTCAGAGCAGAGTGGTGCCATCATCTACTGCCCGGTGAACCGCACCTTCCCACTGCGCTACCTCGAGGCCAGCTATGGCCTGG
GACAGGGGAGTAGCAAGCCTGCTAGCCCCGTCAGCCCCTCAGGCCCCAAGGGCAGCCACATGAAGCGGCGCAGCGTCACCATGACCGATG
GGCTCACTGCTGACAAGGTCACCCGCAGCGATGGCTGCCCCACCAGTACGTCGCTGCCCCGCCCTCGGGACTCCATCCGCAGCTGTGCCC
TCAGCATGGACCAGATCCCAGACCTGCACTCACCCATGTCGCCCATCTCCGAGAGCCCTAGCTCCCCTGCCTACAGCACTGTAACCCGTG
TCCATGCCGCCCCTGCAGCCCCTTCTGCCACAGCATTGCCTGCCTCCCCTGTCGCCCGCCGTTCCAGTGAGCCCCAGCTGTGTCCCGGAA
GTGCCCCAAAGACCCATGGGGAGTCAGACAAGGGCCCCCACACCAGCCCCTCCCACACCCTTGGCAAGGCCTCCCCGTCACCATCACTCA
GCAGCTACAGTGACCCGGACTCTGGCCACTACTGCCAGCTCCAGCCTCCCGTGCGTGGCAGCCGAGAGTGGGCAGCGACTGAGACCTCCA
GCCAGCAGGCCAGGAGCTATGGGGAGAGGCTAAAGGAACTGTCAGAAAATGGGGCCCCTGAAGGGGACTGGGGCAAGACCTTCACAGTCC
CCATCGTGGAAGTCACTTCTTCCTTCAACCCGGCCACCTTCCAGTCACTACTGATCCCCAGGGATAACCGGCCACTGGAGGTGGGCCTTC
TGCGCAAGGTCAAGGAGCTGCTGGCAGAAGTGGATGCCCGGACGCTGGCCCGGCATGTCACCAAGGTGGACTGCCTGGTTGCTAGGATAC
TGGGCGTTACCAAGGAGATGCAGACCCTAATGGGAGTCCGCTGGGGCATGGAACTGCTCACCCTCCCCCATGGCCGGCAGCTACGCCTAG
ACCTGCTGGAAAGGTTCCACACCATGTCCATCATGCTGGCCGTGGACATCCTGGGCTGCACCGGCTCTGCGGAGGAGCGGGCAGCGCTGC
TGCACAAGACCATTCAGCTGGCGGCCGAGCTGCGGGGGACTATGGGCAACATGTTCAGCTTCGCGGCGGTCATGGGTGCCCTGGACATGG
CCCAGATTTCTCGGCTGGAGCAGACATGGGTGACCCTGCGGCAGCGACACACAGAGGGTGCCATCCTGTACGAGAAGAAGCTCAAGCCTT
TTCTCAAGAGCCTCAACGAGGGCAAAGAAGGCCCGCCGCTGAGCAACACCACGTTTCCTCATGTGCTGCCCCTCATCACCCTGCTGGAGT
GTGACTCGGCCCCACCAGAGGGCCCTGAGCCCTGGGGCAGCACGGAGCACGGCGTGGAGGTGGTGCTGGCTCACCTGGAGGCCGCCCGCA
CAGTGGCACACCACGGAGGCCTGTACCACACCAATGCTGAAGTCAAGCTGCAGGGGTTCCAGGCCCGGCCGGAGCTCCTGGAGGTGTTCA
GCACGGAGTTCCAGATGCGCCTTCTCTGGGGCAGTCAGGGTGCCAGCAGCAGCCAGGCCCGGCGCTATGAGAAGTTCGACAAGGTCCTCA
CTGCCCTGTCCCACAAGCTGGAACCTGCTGTCCGCTCCAGCGAGCTGTGACCCCAGGGACATTTCCCCTCTGCAGCTGCGGACAGCGTCA
GGGGCAGAGGGGCACACAACTTTCCCCAGAGCACCCCAAGGACACTGTGATCAACCCGAGAATGTTCTGGGTTCAACTCAAGCATCTCCC
TTGCACCTCCAGGGTCCTGCGTGGACTCTGGGTTCCATCCCACCTGCTACATGCTCACCAGGTCTCCATTGAGGAAGAACAGGAACGCCG
GTTCCCCCACCAGCTTTTGCTGCTCCCCTTCCTGCTGGGGTTCCCTGTTTTCGAGCCATGGGAGGCAGGCTGCTCACGCCTCCTCACTCT
CTGTCTGTCCCTCACCAACACCAAGGCCTCCATCTCACTGTAAATAAGTCTCTGTTCTGTAAATAGATGTACAGAAGCCATGTTATTTCT

>In-frame_ENST00000370243_ENST00000420366_TCGA-CJ-4870-01A_BCAR3_chr1_94057822_-_SH2D3C_chr9_130511944_length(amino acids)=863AA_start in transcript=68_stop in transcript=2659
MLGGTRAASSRALASPDPLPVGAALPATPPCPARPLFAEAGRGRADARAQSALVEAQGSEEASFSELRIMAAGKFASLPRNMPVNHQFPL
ASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLL
DPTVEYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKI
NKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKR
RSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSS
EPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGD
WGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLP
HGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAIL
YEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQAR

--------------------------------------------------------------
>In-frame_ENST00000370247_ENST00000373277_TCGA-CJ-4870-01A_BCAR3_chr1_94057822_-_SH2D3C_chr9_130511944_length(transcript)=2708nt_BP=380nt
AGACTAGCCTGGGAGAAGGAGCCGACTCACTCCCCCGGCTGCCGACTTCCCTGACTTCTGGGCAGAAACAGCACAGCTGCTGTGGTGGGC
TAGGGCTTTAACGTCCGAAGCCCCCTTTCTTTTAACCCTAAAGAAAGTGTGTGGTCCCCGGGACTGAAGACCGAAAGATGCCTAAGGAAT
GCAGTGCTTTCCACGCCCTCTCAGCAGCTCTGTGCTGCTTCTATCACCGCAAGTCTTTCATTGGAGTCAAGTTCTCCAAGGAGAGGCACA
TCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACCTGCGCAGCCATGCCTGGTACC
ACGGCCGCATCCCCCGACAGGTCTCGGAGACCTTGGTACAACGCAACGGCGACTTCCTCATCCGGGACTCACTCACCAGCCTGGGCGACT
ATGTGCTCACGTGCCGCTGGCGCAACCAGGCCTTGCACTTCAAGATCAACAAGGTGGTGGTGAAGGCAGGCGAGAGCTACACACACATCC
AGTACCTGTTTGAGCAGGAGAGCTTTGACCACGTGCCCGCCCTCGTGCGCTATCATGTGGGCAGCCGCAAGGCTGTGTCAGAGCAGAGTG
GTGCCATCATCTACTGCCCGGTGAACCGCACCTTCCCACTGCGCTACCTCGAGGCCAGCTATGGCCTGGGACAGGGGAGTAGCAAGCCTG
CTAGCCCCGTCAGCCCCTCAGGCCCCAAGGGCAGCCACATGAAGCGGCGCAGCGTCACCATGACCGATGGGCTCACTGCTGACAAGGTCA
CCCGCAGCGATGGCTGCCCCACCAGTACGTCGCTGCCCCGCCCTCGGGACTCCATCCGCAGCTGTGCCCTCAGCATGGACCAGATCCCAG
ACCTGCACTCACCCATGTCGCCCATCTCCGAGAGCCCTAGCTCCCCTGCCTACAGCACTGTAACCCGTGTCCATGCCGCCCCTGCAGCCC
CTTCTGCCACAGCATTGCCTGCCTCCCCTGTCGCCCGCCGTTCCAGTGAGCCCCAGCTGTGTCCCGGAAGTGCCCCAAAGACCCATGGGG
AGTCAGACAAGGGCCCCCACACCAGCCCCTCCCACACCCTTGGCAAGGCCTCCCCGTCACCATCACTCAGCAGCTACAGTGACCCGGACT
CTGGCCACTACTGCCAGCTCCAGCCTCCCGTGCGTGGCAGCCGAGAGTGGGCAGCGACTGAGACCTCCAGCCAGCAGGCCAGGAGCTATG
GGGAGAGGCTAAAGGAACTGTCAGAAAATGGGGCCCCTGAAGGGGACTGGGGCAAGACCTTCACAGTCCCCATCGTGGAAGTCACTTCTT
CCTTCAACCCGGCCACCTTCCAGTCACTACTGATCCCCAGGGATAACCGGCCACTGGAGGTGGGCCTTCTGCGCAAGGTCAAGGAGCTGC
TGGCAGAAGTGGATGCCCGGACGCTGGCCCGGCATGTCACCAAGGTGGACTGCCTGGTTGCTAGGATACTGGGCGTTACCAAGGAGATGC
AGACCCTAATGGGAGTCCGCTGGGGCATGGAACTGCTCACCCTCCCCCATGGCCGGCAGCTACGCCTAGACCTGCTGGAAAGGTTCCACA
CCATGTCCATCATGCTGGCCGTGGACATCCTGGGCTGCACCGGCTCTGCGGAGGAGCGGGCAGCGCTGCTGCACAAGACCATTCAGCTGG
CGGCCGAGCTGCGGGGGACTATGGGCAACATGTTCAGCTTCGCGGCGGTCATGGGTGCCCTGGACATGGCCCAGATTTCTCGGCTGGAGC
AGACATGGGTGACCCTGCGGCAGCGACACACAGAGGGTGCCATCCTGTACGAGAAGAAGCTCAAGCCTTTTCTCAAGAGCCTCAACGAGG
GCAAAGAAGGCCCGCCGCTGAGCAACACCACGTTTCCTCATGTGCTGCCCCTCATCACCCTGCTGGAGTGTGACTCGGCCCCACCAGAGG
GCCCTGAGCCCTGGGGCAGCACGGAGCACGGCGTGGAGGTGGTGCTGGCTCACCTGGAGGCCGCCCGCACAGTGGCACACCACGGAGGCC
TGTACCACACCAATGCTGAAGTCAAGCTGCAGGGGTTCCAGGCCCGGCCGGAGCTCCTGGAGGTGTTCAGCACGGAGTTCCAGATGCGCC
TTCTCTGGGGCAGTCAGGGTGCCAGCAGCAGCCAGGCCCGGCGCTATGAGAAGTTCGACAAGGTCCTCACTGCCCTGTCCCACAAGCTGG
AACCTGCTGTCCGCTCCAGCGAGCTGTGACCCCAGGGACATTTCCCCTCTGCAGCTGCGGACAGCGTCAGGGGCAGAGGGGCACACAACT
TTCCCCAGAGCACCCCAAGGACACTGTGATCAACCCGAGAATGTTCTGGGTTCAACTCAAGCATCTCCCTTGCACCTCCAGGGTCCTGCG
TGGACTCTGGGTTCCATCCCACCTGCTACATGCTCACCAGGTCTCCATTGAGGAAGAACAGGAACGCCGGTTCCCCCACCAGCTTTTGCT
GCTCCCCTTCCTGCTGGGGTTCCCTGTTTTCGAGCCATGGGAGGCAGGCTGCTCACGCCTCCTCACTCTCTGTCTGTCCCTCACCAACAC
CAAGGCCTCCATCTCACTGTAAATAAGTCTCTGTTCTGTAAATAGATGTACAGAAGCCATGTTATTTCTTTCATATAATAAACTTTTATG

>In-frame_ENST00000370247_ENST00000373277_TCGA-CJ-4870-01A_BCAR3_chr1_94057822_-_SH2D3C_chr9_130511944_length(amino acids)=703AA_start in transcript=167_stop in transcript=2278
MPKECSAFHALSAALCCFYHRKSFIGVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSETLVQRNGDFLIRDSLT
SLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQG
SSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHA
APAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQ
ARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGV
TKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQI
SRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVA

--------------------------------------------------------------
>In-frame_ENST00000370247_ENST00000373274_TCGA-CJ-4870-01A_BCAR3_chr1_94057822_-_SH2D3C_chr9_130511944_length(transcript)=2707nt_BP=380nt
AGACTAGCCTGGGAGAAGGAGCCGACTCACTCCCCCGGCTGCCGACTTCCCTGACTTCTGGGCAGAAACAGCACAGCTGCTGTGGTGGGC
TAGGGCTTTAACGTCCGAAGCCCCCTTTCTTTTAACCCTAAAGAAAGTGTGTGGTCCCCGGGACTGAAGACCGAAAGATGCCTAAGGAAT
GCAGTGCTTTCCACGCCCTCTCAGCAGCTCTGTGCTGCTTCTATCACCGCAAGTCTTTCATTGGAGTCAAGTTCTCCAAGGAGAGGCACA
TCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACCTGCGCAGCCATGCCTGGTACC
ACGGCCGCATCCCCCGACAGGTCTCGGAGACCTTGGTACAACGCAACGGCGACTTCCTCATCCGGGACTCACTCACCAGCCTGGGCGACT
ATGTGCTCACGTGCCGCTGGCGCAACCAGGCCTTGCACTTCAAGATCAACAAGGTGGTGGTGAAGGCAGGCGAGAGCTACACACACATCC
AGTACCTGTTTGAGCAGGAGAGCTTTGACCACGTGCCCGCCCTCGTGCGCTATCATGTGGGCAGCCGCAAGGCTGTGTCAGAGCAGAGTG
GTGCCATCATCTACTGCCCGGTGAACCGCACCTTCCCACTGCGCTACCTCGAGGCCAGCTATGGCCTGGGACAGGGGAGTAGCAAGCCTG
CTAGCCCCGTCAGCCCCTCAGGCCCCAAGGGCAGCCACATGAAGCGGCGCAGCGTCACCATGACCGATGGGCTCACTGCTGACAAGGTCA
CCCGCAGCGATGGCTGCCCCACCAGTACGTCGCTGCCCCGCCCTCGGGACTCCATCCGCAGCTGTGCCCTCAGCATGGACCAGATCCCAG
ACCTGCACTCACCCATGTCGCCCATCTCCGAGAGCCCTAGCTCCCCTGCCTACAGCACTGTAACCCGTGTCCATGCCGCCCCTGCAGCCC
CTTCTGCCACAGCATTGCCTGCCTCCCCTGTCGCCCGCCGTTCCAGTGAGCCCCAGCTGTGTCCCGGAAGTGCCCCAAAGACCCATGGGG
AGTCAGACAAGGGCCCCCACACCAGCCCCTCCCACACCCTTGGCAAGGCCTCCCCGTCACCATCACTCAGCAGCTACAGTGACCCGGACT
CTGGCCACTACTGCCAGCTCCAGCCTCCCGTGCGTGGCAGCCGAGAGTGGGCAGCGACTGAGACCTCCAGCCAGCAGGCCAGGAGCTATG
GGGAGAGGCTAAAGGAACTGTCAGAAAATGGGGCCCCTGAAGGGGACTGGGGCAAGACCTTCACAGTCCCCATCGTGGAAGTCACTTCTT
CCTTCAACCCGGCCACCTTCCAGTCACTACTGATCCCCAGGGATAACCGGCCACTGGAGGTGGGCCTTCTGCGCAAGGTCAAGGAGCTGC
TGGCAGAAGTGGATGCCCGGACGCTGGCCCGGCATGTCACCAAGGTGGACTGCCTGGTTGCTAGGATACTGGGCGTTACCAAGGAGATGC
AGACCCTAATGGGAGTCCGCTGGGGCATGGAACTGCTCACCCTCCCCCATGGCCGGCAGCTACGCCTAGACCTGCTGGAAAGGTTCCACA
CCATGTCCATCATGCTGGCCGTGGACATCCTGGGCTGCACCGGCTCTGCGGAGGAGCGGGCAGCGCTGCTGCACAAGACCATTCAGCTGG
CGGCCGAGCTGCGGGGGACTATGGGCAACATGTTCAGCTTCGCGGCGGTCATGGGTGCCCTGGACATGGCCCAGATTTCTCGGCTGGAGC
AGACATGGGTGACCCTGCGGCAGCGACACACAGAGGGTGCCATCCTGTACGAGAAGAAGCTCAAGCCTTTTCTCAAGAGCCTCAACGAGG
GCAAAGAAGGCCCGCCGCTGAGCAACACCACGTTTCCTCATGTGCTGCCCCTCATCACCCTGCTGGAGTGTGACTCGGCCCCACCAGAGG
GCCCTGAGCCCTGGGGCAGCACGGAGCACGGCGTGGAGGTGGTGCTGGCTCACCTGGAGGCCGCCCGCACAGTGGCACACCACGGAGGCC
TGTACCACACCAATGCTGAAGTCAAGCTGCAGGGGTTCCAGGCCCGGCCGGAGCTCCTGGAGGTGTTCAGCACGGAGTTCCAGATGCGCC
TTCTCTGGGGCAGTCAGGGTGCCAGCAGCAGCCAGGCCCGGCGCTATGAGAAGTTCGACAAGGTCCTCACTGCCCTGTCCCACAAGCTGG
AACCTGCTGTCCGCTCCAGCGAGCTGTGACCCCAGGGACATTTCCCCTCTGCAGCTGCGGACAGCGTCAGGGGCAGAGGGGCACACAACT
TTCCCCAGAGCACCCCAAGGACACTGTGATCAACCCGAGAATGTTCTGGGTTCAACTCAAGCATCTCCCTTGCACCTCCAGGGTCCTGCG
TGGACTCTGGGTTCCATCCCACCTGCTACATGCTCACCAGGTCTCCATTGAGGAAGAACAGGAACGCCGGTTCCCCCACCAGCTTTTGCT
GCTCCCCTTCCTGCTGGGGTTCCCTGTTTTCGAGCCATGGGAGGCAGGCTGCTCACGCCTCCTCACTCTCTGTCTGTCCCTCACCAACAC
CAAGGCCTCCATCTCACTGTAAATAAGTCTCTGTTCTGTAAATAGATGTACAGAAGCCATGTTATTTCTTTCATATAATAAACTTTTATG

>In-frame_ENST00000370247_ENST00000373274_TCGA-CJ-4870-01A_BCAR3_chr1_94057822_-_SH2D3C_chr9_130511944_length(amino acids)=703AA_start in transcript=167_stop in transcript=2278
MPKECSAFHALSAALCCFYHRKSFIGVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSETLVQRNGDFLIRDSLT
SLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQG
SSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHA
APAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQ
ARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGV
TKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQI
SRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVA

--------------------------------------------------------------
>In-frame_ENST00000370247_ENST00000420366_TCGA-CJ-4870-01A_BCAR3_chr1_94057822_-_SH2D3C_chr9_130511944_length(transcript)=2707nt_BP=380nt
AGACTAGCCTGGGAGAAGGAGCCGACTCACTCCCCCGGCTGCCGACTTCCCTGACTTCTGGGCAGAAACAGCACAGCTGCTGTGGTGGGC
TAGGGCTTTAACGTCCGAAGCCCCCTTTCTTTTAACCCTAAAGAAAGTGTGTGGTCCCCGGGACTGAAGACCGAAAGATGCCTAAGGAAT
GCAGTGCTTTCCACGCCCTCTCAGCAGCTCTGTGCTGCTTCTATCACCGCAAGTCTTTCATTGGAGTCAAGTTCTCCAAGGAGAGGCACA
TCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACCTGCGCAGCCATGCCTGGTACC
ACGGCCGCATCCCCCGACAGGTCTCGGAGACCTTGGTACAACGCAACGGCGACTTCCTCATCCGGGACTCACTCACCAGCCTGGGCGACT
ATGTGCTCACGTGCCGCTGGCGCAACCAGGCCTTGCACTTCAAGATCAACAAGGTGGTGGTGAAGGCAGGCGAGAGCTACACACACATCC
AGTACCTGTTTGAGCAGGAGAGCTTTGACCACGTGCCCGCCCTCGTGCGCTATCATGTGGGCAGCCGCAAGGCTGTGTCAGAGCAGAGTG
GTGCCATCATCTACTGCCCGGTGAACCGCACCTTCCCACTGCGCTACCTCGAGGCCAGCTATGGCCTGGGACAGGGGAGTAGCAAGCCTG
CTAGCCCCGTCAGCCCCTCAGGCCCCAAGGGCAGCCACATGAAGCGGCGCAGCGTCACCATGACCGATGGGCTCACTGCTGACAAGGTCA
CCCGCAGCGATGGCTGCCCCACCAGTACGTCGCTGCCCCGCCCTCGGGACTCCATCCGCAGCTGTGCCCTCAGCATGGACCAGATCCCAG
ACCTGCACTCACCCATGTCGCCCATCTCCGAGAGCCCTAGCTCCCCTGCCTACAGCACTGTAACCCGTGTCCATGCCGCCCCTGCAGCCC
CTTCTGCCACAGCATTGCCTGCCTCCCCTGTCGCCCGCCGTTCCAGTGAGCCCCAGCTGTGTCCCGGAAGTGCCCCAAAGACCCATGGGG
AGTCAGACAAGGGCCCCCACACCAGCCCCTCCCACACCCTTGGCAAGGCCTCCCCGTCACCATCACTCAGCAGCTACAGTGACCCGGACT
CTGGCCACTACTGCCAGCTCCAGCCTCCCGTGCGTGGCAGCCGAGAGTGGGCAGCGACTGAGACCTCCAGCCAGCAGGCCAGGAGCTATG
GGGAGAGGCTAAAGGAACTGTCAGAAAATGGGGCCCCTGAAGGGGACTGGGGCAAGACCTTCACAGTCCCCATCGTGGAAGTCACTTCTT
CCTTCAACCCGGCCACCTTCCAGTCACTACTGATCCCCAGGGATAACCGGCCACTGGAGGTGGGCCTTCTGCGCAAGGTCAAGGAGCTGC
TGGCAGAAGTGGATGCCCGGACGCTGGCCCGGCATGTCACCAAGGTGGACTGCCTGGTTGCTAGGATACTGGGCGTTACCAAGGAGATGC
AGACCCTAATGGGAGTCCGCTGGGGCATGGAACTGCTCACCCTCCCCCATGGCCGGCAGCTACGCCTAGACCTGCTGGAAAGGTTCCACA
CCATGTCCATCATGCTGGCCGTGGACATCCTGGGCTGCACCGGCTCTGCGGAGGAGCGGGCAGCGCTGCTGCACAAGACCATTCAGCTGG
CGGCCGAGCTGCGGGGGACTATGGGCAACATGTTCAGCTTCGCGGCGGTCATGGGTGCCCTGGACATGGCCCAGATTTCTCGGCTGGAGC
AGACATGGGTGACCCTGCGGCAGCGACACACAGAGGGTGCCATCCTGTACGAGAAGAAGCTCAAGCCTTTTCTCAAGAGCCTCAACGAGG
GCAAAGAAGGCCCGCCGCTGAGCAACACCACGTTTCCTCATGTGCTGCCCCTCATCACCCTGCTGGAGTGTGACTCGGCCCCACCAGAGG
GCCCTGAGCCCTGGGGCAGCACGGAGCACGGCGTGGAGGTGGTGCTGGCTCACCTGGAGGCCGCCCGCACAGTGGCACACCACGGAGGCC
TGTACCACACCAATGCTGAAGTCAAGCTGCAGGGGTTCCAGGCCCGGCCGGAGCTCCTGGAGGTGTTCAGCACGGAGTTCCAGATGCGCC
TTCTCTGGGGCAGTCAGGGTGCCAGCAGCAGCCAGGCCCGGCGCTATGAGAAGTTCGACAAGGTCCTCACTGCCCTGTCCCACAAGCTGG
AACCTGCTGTCCGCTCCAGCGAGCTGTGACCCCAGGGACATTTCCCCTCTGCAGCTGCGGACAGCGTCAGGGGCAGAGGGGCACACAACT
TTCCCCAGAGCACCCCAAGGACACTGTGATCAACCCGAGAATGTTCTGGGTTCAACTCAAGCATCTCCCTTGCACCTCCAGGGTCCTGCG
TGGACTCTGGGTTCCATCCCACCTGCTACATGCTCACCAGGTCTCCATTGAGGAAGAACAGGAACGCCGGTTCCCCCACCAGCTTTTGCT
GCTCCCCTTCCTGCTGGGGTTCCCTGTTTTCGAGCCATGGGAGGCAGGCTGCTCACGCCTCCTCACTCTCTGTCTGTCCCTCACCAACAC
CAAGGCCTCCATCTCACTGTAAATAAGTCTCTGTTCTGTAAATAGATGTACAGAAGCCATGTTATTTCTTTCATATAATAAACTTTTATG

>In-frame_ENST00000370247_ENST00000420366_TCGA-CJ-4870-01A_BCAR3_chr1_94057822_-_SH2D3C_chr9_130511944_length(amino acids)=703AA_start in transcript=167_stop in transcript=2278
MPKECSAFHALSAALCCFYHRKSFIGVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSETLVQRNGDFLIRDSLT
SLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQG
SSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHA
APAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQ
ARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGV
TKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQI
SRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVA

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Fusion Gene PPI Analysis for BCAR3-SH2D3C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BCAR3-SH2D3C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BCAR3-SH2D3C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBCAR3C0006142Malignant neoplasm of breast1CTD_human
HgeneBCAR3C0013146Drug abuse1CTD_human
HgeneBCAR3C0013170Drug habituation1CTD_human
HgeneBCAR3C0013222Drug Use Disorders1CTD_human
HgeneBCAR3C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneBCAR3C0038580Substance Dependence1CTD_human
HgeneBCAR3C0038586Substance Use Disorders1CTD_human
HgeneBCAR3C0236969Substance-Related Disorders1CTD_human
HgeneBCAR3C0678222Breast Carcinoma1CTD_human
HgeneBCAR3C0740858Substance abuse problem1CTD_human
HgeneBCAR3C1257931Mammary Neoplasms, Human1CTD_human
HgeneBCAR3C1458155Mammary Neoplasms1CTD_human
HgeneBCAR3C1510472Drug Dependence1CTD_human
HgeneBCAR3C4316881Prescription Drug Abuse1CTD_human
HgeneBCAR3C4704874Mammary Carcinoma, Human1CTD_human