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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TOP2B-TOP2B (FusionGDB2 ID:92456)

Fusion Gene Summary for TOP2B-TOP2B

check button Fusion gene summary
Fusion gene informationFusion gene name: TOP2B-TOP2B
Fusion gene ID: 92456
HgeneTgene
Gene symbol

TOP2B

TOP2B

Gene ID

7155

7155

Gene nameDNA topoisomerase II betaDNA topoisomerase II beta
SynonymsTOPIIB|top2betaTOPIIB|top2beta
Cytomap

3p24.2

3p24.2

Type of geneprotein-codingprotein-coding
DescriptionDNA topoisomerase 2-betaDNA topoisomerase II, 180 kDDNA topoisomerase II, beta isozymeU937 associated antigenantigen MLAA-44topo II betatopoisomerase (DNA) II beta 180kDatopoisomerase II betatopoisomerase IIbDNA topoisomerase 2-betaDNA topoisomerase II, 180 kDDNA topoisomerase II, beta isozymeU937 associated antigenantigen MLAA-44topo II betatopoisomerase (DNA) II beta 180kDatopoisomerase II betatopoisomerase IIb
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000435706, ENST00000264331, 
ENST00000542520, ENST00000540199, 
ENST00000475717, 		ENST00000435706, 
ENST00000264331, ENST00000542520, 
ENST00000540199, ENST00000475717, 
Fusion gene scores* DoF score8 X 10 X 4=32013 X 12 X 6=936
# samples 914
** MAII scorelog2(9/320*10)=-1.83007499855769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/936*10)=-2.74108170263844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TOP2B [Title/Abstract] AND TOP2B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTOP2B(25640945)-TOP2B(25642718), # samples:1
TOP2B(25660268)-TOP2B(25660244), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTOP2B

GO:0006265

DNA topological change

10684600

TgeneTOP2B

GO:0006265

DNA topological change

10684600


check buttonFusion gene breakpoints across TOP2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TOP2B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF154577TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
ChiTaRS5.0N/ABQ431453TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-


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Fusion Gene ORF analysis for TOP2B-TOP2B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000435706ENST00000435706TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-3CDSENST00000435706ENST00000264331TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-3CDSENST00000435706ENST00000542520TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-3CDSENST00000435706ENST00000540199TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-intronENST00000435706ENST00000475717TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-3CDSENST00000264331ENST00000435706TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-3CDSENST00000264331ENST00000264331TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-3CDSENST00000264331ENST00000542520TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-3CDSENST00000264331ENST00000540199TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-intronENST00000264331ENST00000475717TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-3CDSENST00000542520ENST00000435706TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-3CDSENST00000542520ENST00000264331TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-3CDSENST00000542520ENST00000542520TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-3CDSENST00000542520ENST00000540199TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-intronENST00000542520ENST00000475717TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-3CDSENST00000540199ENST00000435706TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-3CDSENST00000540199ENST00000264331TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-3CDSENST00000540199ENST00000542520TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-3CDSENST00000540199ENST00000540199TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-intronENST00000540199ENST00000475717TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-3CDSENST00000475717ENST00000435706TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-3CDSENST00000475717ENST00000264331TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-3CDSENST00000475717ENST00000542520TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-3CDSENST00000475717ENST00000540199TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-intronENST00000475717ENST00000475717TOP2Bchr3

25640945

-TOP2Bchr3

25642718

-
intron-3CDSENST00000435706ENST00000435706TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-3CDSENST00000435706ENST00000264331TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-5UTRENST00000435706ENST00000542520TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-intronENST00000435706ENST00000540199TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-intronENST00000435706ENST00000475717TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-3CDSENST00000264331ENST00000435706TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-3CDSENST00000264331ENST00000264331TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-5UTRENST00000264331ENST00000542520TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-intronENST00000264331ENST00000540199TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-intronENST00000264331ENST00000475717TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-3CDSENST00000542520ENST00000435706TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-3CDSENST00000542520ENST00000264331TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-5UTRENST00000542520ENST00000542520TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-intronENST00000542520ENST00000540199TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-intronENST00000542520ENST00000475717TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-3CDSENST00000540199ENST00000435706TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-3CDSENST00000540199ENST00000264331TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-5UTRENST00000540199ENST00000542520TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-intronENST00000540199ENST00000540199TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-intronENST00000540199ENST00000475717TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-3CDSENST00000475717ENST00000435706TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-3CDSENST00000475717ENST00000264331TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-5UTRENST00000475717ENST00000542520TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-intronENST00000475717ENST00000540199TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-
intron-intronENST00000475717ENST00000475717TOP2Bchr3

25660268

+TOP2Bchr3

25660244

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TOP2B-TOP2B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TOP2B-TOP2B


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TOP2B-TOP2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TOP2B-TOP2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TOP2B-TOP2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TOP2B-TOP2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTOP2BC0023466Leukemia, Monocytic, Chronic1CTD_human
HgeneTOP2BC0023470Myeloid Leukemia1CTD_human
HgeneTOP2BC0282612Prostatic Intraepithelial Neoplasias1CTD_human
TgeneTOP2BC0023466Leukemia, Monocytic, Chronic1CTD_human
TgeneTOP2BC0023470Myeloid Leukemia1CTD_human
TgeneTOP2BC0282612Prostatic Intraepithelial Neoplasias1CTD_human