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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TOX2-EIF5A (FusionGDB2 ID:92515)

Fusion Gene Summary for TOX2-EIF5A

check button Fusion gene summary
Fusion gene informationFusion gene name: TOX2-EIF5A
Fusion gene ID: 92515
HgeneTgene
Gene symbol

TOX2

EIF5A

Gene ID

84969

143244

Gene nameTOX high mobility group box family member 2eukaryotic translation initiation factor 5A like 1
SynonymsC20orf100|GCX-1|GCX1|dJ1108D11.2|dJ495O3.1EIF5A|EIF5AP1|bA342M3.3|eIF-4D|eIF-5A|eIF-5A-1|eIF-5A1
Cytomap

20q13.12

10q22.3

Type of geneprotein-codingprotein-coding
DescriptionTOX high mobility group box family member 2granulosa cell HMG box 1eukaryotic translation initiation factor 5A-1-likeEukaryotic translation initiation factor 5A-1Rev-binding factoreukaryotic translation initiation factor 5A pseudogene 1
Modification date2020031320200313
UniProtAcc.

Q6IS14

Ensembl transtripts involved in fusion geneENST00000341197, ENST00000423191, 
ENST00000372999, ENST00000358131, 
ENST00000435864, 		ENST00000336452, 
ENST00000336458, ENST00000576930, 
ENST00000572815, ENST00000573542, 
ENST00000419711, ENST00000571955, 
ENST00000416016, 
Fusion gene scores* DoF score5 X 5 X 3=759 X 5 X 8=360
# samples 59
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TOX2 [Title/Abstract] AND EIF5A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTOX2(42635432)-EIF5A(7212934), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTOX2

GO:0045944

positive regulation of transcription by RNA polymerase II

25352127


check buttonFusion gene breakpoints across TOX2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EIF5A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-J4-A67N-01ATOX2chr20

42635432

+EIF5Achr17

7212934

+


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Fusion Gene ORF analysis for TOX2-EIF5A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000341197ENST00000336452TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000341197ENST00000336458TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000341197ENST00000576930TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000341197ENST00000572815TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000341197ENST00000573542TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000341197ENST00000419711TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000341197ENST00000571955TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000341197ENST00000416016TOX2chr20

42635432

+EIF5Achr17

7212934

+
In-frameENST00000423191ENST00000336452TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000423191ENST00000336458TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000423191ENST00000576930TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000423191ENST00000572815TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000423191ENST00000573542TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000423191ENST00000419711TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000423191ENST00000571955TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000423191ENST00000416016TOX2chr20

42635432

+EIF5Achr17

7212934

+
In-frameENST00000372999ENST00000336452TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000372999ENST00000336458TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000372999ENST00000576930TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000372999ENST00000572815TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000372999ENST00000573542TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000372999ENST00000419711TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000372999ENST00000571955TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000372999ENST00000416016TOX2chr20

42635432

+EIF5Achr17

7212934

+
In-frameENST00000358131ENST00000336452TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000358131ENST00000336458TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000358131ENST00000576930TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000358131ENST00000572815TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000358131ENST00000573542TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000358131ENST00000419711TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000358131ENST00000571955TOX2chr20

42635432

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000358131ENST00000416016TOX2chr20

42635432

+EIF5Achr17

7212934

+
intron-3CDSENST00000435864ENST00000336452TOX2chr20

42635432

+EIF5Achr17

7212934

+
intron-5UTRENST00000435864ENST00000336458TOX2chr20

42635432

+EIF5Achr17

7212934

+
intron-5UTRENST00000435864ENST00000576930TOX2chr20

42635432

+EIF5Achr17

7212934

+
intron-5UTRENST00000435864ENST00000572815TOX2chr20

42635432

+EIF5Achr17

7212934

+
intron-5UTRENST00000435864ENST00000573542TOX2chr20

42635432

+EIF5Achr17

7212934

+
intron-5UTRENST00000435864ENST00000419711TOX2chr20

42635432

+EIF5Achr17

7212934

+
intron-5UTRENST00000435864ENST00000571955TOX2chr20

42635432

+EIF5Achr17

7212934

+
intron-5UTRENST00000435864ENST00000416016TOX2chr20

42635432

+EIF5Achr17

7212934

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000341197TOX2chr2042635432+ENST00000336452EIF5Achr177212934+157043928924298
ENST00000423191TOX2chr2042635432+ENST00000336452EIF5Achr177212934+150237186856256
ENST00000372999TOX2chr2042635432+ENST00000336452EIF5Achr177212934+1610479140964274
ENST00000358131TOX2chr2042635432+ENST00000336452EIF5Achr177212934+17776461691131320

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000341197ENST00000336452TOX2chr2042635432+EIF5Achr177212934+0.0011306660.99886936
ENST00000423191ENST00000336452TOX2chr2042635432+EIF5Achr177212934+0.0065055240.99349445
ENST00000372999ENST00000336452TOX2chr2042635432+EIF5Achr177212934+0.0063561640.9936439
ENST00000358131ENST00000336452TOX2chr2042635432+EIF5Achr177212934+0.0030680250.9969319

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Fusion Genomic Features for TOX2-EIF5A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TOX2chr2042635432+EIF5Achr177212933+5.09E-081
TOX2chr2042635432+EIF5Achr177212933+5.09E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TOX2-EIF5A


check button Go to

FGviewer for the breakpoints of chr20:42635432-chr17:7212934

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EIF5A

Q6IS14

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTOX2chr20:42635432chr17:7212934ENST00000341197+3976_114137.0507.0RegionRequired for transcriptional activation
HgeneTOX2chr20:42635432chr17:7212934ENST00000358131+3876_114146.0489.0RegionRequired for transcriptional activation
TgeneEIF5Achr20:42635432chr17:7212934ENST000003364520620_9023.0357.3333333333333RegionNote=DOHH-binding
TgeneEIF5Achr20:42635432chr17:7212934ENST000003364580620_900239.66666666666666RegionNote=DOHH-binding
TgeneEIF5Achr20:42635432chr17:7212934ENST000004160160620_900298.0RegionNote=DOHH-binding
TgeneEIF5Achr20:42635432chr17:7212934ENST000004197110620_900319.6666666666667RegionNote=DOHH-binding
TgeneEIF5Achr20:42635432chr17:7212934ENST000005719551720_900319.6666666666667RegionNote=DOHH-binding
TgeneEIF5Achr20:42635432chr17:7212934ENST000005735420620_900245.66666666666666RegionNote=DOHH-binding
TgeneEIF5Achr20:42635432chr17:7212934ENST000005769301720_900295.3333333333333RegionNote=DOHH-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTOX2chr20:42635432chr17:7212934ENST00000341197+39245_250137.0507.0Compositional biasNote=Poly-Lys
HgeneTOX2chr20:42635432chr17:7212934ENST00000341197+39372_456137.0507.0Compositional biasNote=Pro-rich
HgeneTOX2chr20:42635432chr17:7212934ENST00000358131+38245_250146.0489.0Compositional biasNote=Poly-Lys
HgeneTOX2chr20:42635432chr17:7212934ENST00000358131+38372_456146.0489.0Compositional biasNote=Pro-rich
HgeneTOX2chr20:42635432chr17:7212934ENST00000372999+410245_25095.0465.0Compositional biasNote=Poly-Lys
HgeneTOX2chr20:42635432chr17:7212934ENST00000372999+410372_45695.0465.0Compositional biasNote=Pro-rich
HgeneTOX2chr20:42635432chr17:7212934ENST00000423191+39245_25095.0465.0Compositional biasNote=Poly-Lys
HgeneTOX2chr20:42635432chr17:7212934ENST00000423191+39372_45695.0465.0Compositional biasNote=Pro-rich
HgeneTOX2chr20:42635432chr17:7212934ENST00000341197+39255_323137.0507.0DNA bindingHMG box
HgeneTOX2chr20:42635432chr17:7212934ENST00000358131+38255_323146.0489.0DNA bindingHMG box
HgeneTOX2chr20:42635432chr17:7212934ENST00000372999+410255_32395.0465.0DNA bindingHMG box
HgeneTOX2chr20:42635432chr17:7212934ENST00000423191+39255_32395.0465.0DNA bindingHMG box
HgeneTOX2chr20:42635432chr17:7212934ENST00000341197+39223_252137.0507.0MotifNuclear localization signal
HgeneTOX2chr20:42635432chr17:7212934ENST00000358131+38223_252146.0489.0MotifNuclear localization signal
HgeneTOX2chr20:42635432chr17:7212934ENST00000372999+410223_25295.0465.0MotifNuclear localization signal
HgeneTOX2chr20:42635432chr17:7212934ENST00000423191+39223_25295.0465.0MotifNuclear localization signal
HgeneTOX2chr20:42635432chr17:7212934ENST00000372999+41076_11495.0465.0RegionRequired for transcriptional activation
HgeneTOX2chr20:42635432chr17:7212934ENST00000423191+3976_11495.0465.0RegionRequired for transcriptional activation


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Fusion Gene Sequence for TOX2-EIF5A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000341197_ENST00000336452_TCGA-J4-A67N-01A_TOX2_chr20_42635432_+_EIF5A_chr17_7212934_length(transcript)=1570nt_BP=439nt
AGCCGCCGCCGCCGCCGCCGCGCCCGCCATGGACGTCCGCCTGTACCCCTCGGCGCCCGCGGTGGGCGCGCGGCCCGGGGCCGAGCCGGC
CGGCCTGGCGCACCTGGACTATTACCACGGCGGCAAGTTTGATGGTGACAGTGCCTACGTGGGGATGAGTGACGGAAACCCAGAGCTCCT
GTCAACCAGCCAGACCTACAACGGCCAGAGCGAGAACAACGAAGACTATGAGATCCCCCCGATAACACCTCCCAACCTCCCGGAGCCATC
CCTCCTGCACCTGGGGGACCACGAAGCCAGCTACCACTCGCTGTGCCACGGCCTCACCCCCAACGGTCTGCTCCCTGCCTACTCCTATCA
GGCCATGGACCTCCCAGCCATCATGGTGTCCAACATGCTAGCACAGGACAGCCACCTGCTGTCGGGCCAGCTGCCCACGTTGGAATCGAA
GCCTCTTAAAATGGCAGATGACTTGGACTTCGAGACAGGAGATGCAGGGGCCTCAGCCACCTTCCCAATGCAGTGCTCAGCATTACGTAA
GAATGGCTTTGTGGTGCTCAAAGGCCGGCCATGTAAGATCGTCGAGATGTCTACTTCGAAGACTGGCAAGCACGGCCACGCCAAGGTCCA
TCTGGTTGGTATTGACATCTTTACTGGGAAGAAATATGAAGATATCTGCCCGTCAACTCATAATATGGATGTCCCCAACATCAAAAGGAA
TGACTTCCAGCTGATTGGCATCCAGGATGGGTACCTATCACTGCTCCAGGACAGCGGGGAGGTACGAGAGGACCTTCGTCTCCCTGAGGG
AGACCTTGGCAAGGAGATTGAGCAGAAGTACGACTGTGGAGAAGAGATCCTGATCACGGTGCTGTCTGCCATGACAGAGGAGGCAGCTGT
TGCAATCAAGGCCATGGCAAAATAACTGGCTCCCAGGGTGGCGGTGGTGGCAGCAGTGATCCTCTGAACCTGCAGAGGCCCCCTCCCCGA
GCCTGGCCTGGCTCTGGCCCGGTCCTAAGCTGGACTCCTCCTACACAATTTATTTGACGTTTTATTTTGGTTTTCCCCACCCCCTCAATC
TGTCGGGGAGCCCCTGCCCTTCACCTAGCTCCCTTGGCCAGGAGCGAGCGAAGCTGTGGCCTTGGTGAAGCTGCCCTCCTCTTCTCCCCT
CACACTACAGCCCTGGTGGGGGAGAAGGGGGTGGGTGCTGCTTGTGGTTTAGTCTTTTTTTTTTTTTTTTTTTTAATTCAATCTGGAATC
AGAAAGCGGTGGATTCTGGCAAATGGTCCTTGTGCCCTCCCCACTCATCCCTGGTCTGGTCCCCTGTTGCCTATAGCCCTTTACCCTGAG
CACCACCCCAACAGACTGGGGACCAGCCCCCTCGCCTGCCTGTGTCTCTCCCCAAACCCCTTTAGATGGGGAGGGAAGAGGAGGAGAGGG
GAGGGGACCTGCCCCCTCCTCAGGCATCTGGGAGGGCCCTGCCCCCATGGGCTTTACCCTTCCCTGCGGGCTCTCTCCCCGACACATTTG

>In-frame_ENST00000341197_ENST00000336452_TCGA-J4-A67N-01A_TOX2_chr20_42635432_+_EIF5A_chr17_7212934_length(amino acids)=298AA_start in transcript=28_stop in transcript=924
MDVRLYPSAPAVGARPGAEPAGLAHLDYYHGGKFDGDSAYVGMSDGNPELLSTSQTYNGQSENNEDYEIPPITPPNLPEPSLLHLGDHEA
SYHSLCHGLTPNGLLPAYSYQAMDLPAIMVSNMLAQDSHLLSGQLPTLESKPLKMADDLDFETGDAGASATFPMQCSALRKNGFVVLKGR
PCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQK

--------------------------------------------------------------
>In-frame_ENST00000423191_ENST00000336452_TCGA-J4-A67N-01A_TOX2_chr20_42635432_+_EIF5A_chr17_7212934_length(transcript)=1502nt_BP=371nt
AGCGCGCGTGGGTTTCCCGCAGCCCTGGCGCAGACGCGTGGGCTCCGTGGCGATGCGGGTTTGATGGTGACAGTGCCTACGTGGGGATGA
GTGACGGAAACCCAGAGCTCCTGTCAACCAGCCAGACCTACAACGGCCAGAGCGAGAACAACGAAGACTATGAGATCCCCCCGATAACAC
CTCCCAACCTCCCGGAGCCATCCCTCCTGCACCTGGGGGACCACGAAGCCAGCTACCACTCGCTGTGCCACGGCCTCACCCCCAACGGTC
TGCTCCCTGCCTACTCCTATCAGGCCATGGACCTCCCAGCCATCATGGTGTCCAACATGCTAGCACAGGACAGCCACCTGCTGTCGGGCC
AGCTGCCCACGTTGGAATCGAAGCCTCTTAAAATGGCAGATGACTTGGACTTCGAGACAGGAGATGCAGGGGCCTCAGCCACCTTCCCAA
TGCAGTGCTCAGCATTACGTAAGAATGGCTTTGTGGTGCTCAAAGGCCGGCCATGTAAGATCGTCGAGATGTCTACTTCGAAGACTGGCA
AGCACGGCCACGCCAAGGTCCATCTGGTTGGTATTGACATCTTTACTGGGAAGAAATATGAAGATATCTGCCCGTCAACTCATAATATGG
ATGTCCCCAACATCAAAAGGAATGACTTCCAGCTGATTGGCATCCAGGATGGGTACCTATCACTGCTCCAGGACAGCGGGGAGGTACGAG
AGGACCTTCGTCTCCCTGAGGGAGACCTTGGCAAGGAGATTGAGCAGAAGTACGACTGTGGAGAAGAGATCCTGATCACGGTGCTGTCTG
CCATGACAGAGGAGGCAGCTGTTGCAATCAAGGCCATGGCAAAATAACTGGCTCCCAGGGTGGCGGTGGTGGCAGCAGTGATCCTCTGAA
CCTGCAGAGGCCCCCTCCCCGAGCCTGGCCTGGCTCTGGCCCGGTCCTAAGCTGGACTCCTCCTACACAATTTATTTGACGTTTTATTTT
GGTTTTCCCCACCCCCTCAATCTGTCGGGGAGCCCCTGCCCTTCACCTAGCTCCCTTGGCCAGGAGCGAGCGAAGCTGTGGCCTTGGTGA
AGCTGCCCTCCTCTTCTCCCCTCACACTACAGCCCTGGTGGGGGAGAAGGGGGTGGGTGCTGCTTGTGGTTTAGTCTTTTTTTTTTTTTT
TTTTTTAATTCAATCTGGAATCAGAAAGCGGTGGATTCTGGCAAATGGTCCTTGTGCCCTCCCCACTCATCCCTGGTCTGGTCCCCTGTT
GCCTATAGCCCTTTACCCTGAGCACCACCCCAACAGACTGGGGACCAGCCCCCTCGCCTGCCTGTGTCTCTCCCCAAACCCCTTTAGATG
GGGAGGGAAGAGGAGGAGAGGGGAGGGGACCTGCCCCCTCCTCAGGCATCTGGGAGGGCCCTGCCCCCATGGGCTTTACCCTTCCCTGCG

>In-frame_ENST00000423191_ENST00000336452_TCGA-J4-A67N-01A_TOX2_chr20_42635432_+_EIF5A_chr17_7212934_length(amino acids)=256AA_start in transcript=86_stop in transcript=856
MSDGNPELLSTSQTYNGQSENNEDYEIPPITPPNLPEPSLLHLGDHEASYHSLCHGLTPNGLLPAYSYQAMDLPAIMVSNMLAQDSHLLS
GQLPTLESKPLKMADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHN

--------------------------------------------------------------
>In-frame_ENST00000372999_ENST00000336452_TCGA-J4-A67N-01A_TOX2_chr20_42635432_+_EIF5A_chr17_7212934_length(transcript)=1610nt_BP=479nt
CGCAGCCCTGGCGCAGACGCGTGGGCTCCGTGGCGATGCGGGGTGTTGCCTGAGGCTCCACTGAAGCTATGGCATAATTTGCAGAATTTG
CACTTCATTACTTTTCTGAAATTCAAACAAATTCTGAAACTGCACGAGTTCTGGCTGAGAGCTGTGGATCTGTGCATTTTGATGGTGACA
GTGCCTACGTGGGGATGAGTGACGGAAACCCAGAGCTCCTGTCAACCAGCCAGACCTACAACGGCCAGAGCGAGAACAACGAAGACTATG
AGATCCCCCCGATAACACCTCCCAACCTCCCGGAGCCATCCCTCCTGCACCTGGGGGACCACGAAGCCAGCTACCACTCGCTGTGCCACG
GCCTCACCCCCAACGGTCTGCTCCCTGCCTACTCCTATCAGGCCATGGACCTCCCAGCCATCATGGTGTCCAACATGCTAGCACAGGACA
GCCACCTGCTGTCGGGCCAGCTGCCCACGTTGGAATCGAAGCCTCTTAAAATGGCAGATGACTTGGACTTCGAGACAGGAGATGCAGGGG
CCTCAGCCACCTTCCCAATGCAGTGCTCAGCATTACGTAAGAATGGCTTTGTGGTGCTCAAAGGCCGGCCATGTAAGATCGTCGAGATGT
CTACTTCGAAGACTGGCAAGCACGGCCACGCCAAGGTCCATCTGGTTGGTATTGACATCTTTACTGGGAAGAAATATGAAGATATCTGCC
CGTCAACTCATAATATGGATGTCCCCAACATCAAAAGGAATGACTTCCAGCTGATTGGCATCCAGGATGGGTACCTATCACTGCTCCAGG
ACAGCGGGGAGGTACGAGAGGACCTTCGTCTCCCTGAGGGAGACCTTGGCAAGGAGATTGAGCAGAAGTACGACTGTGGAGAAGAGATCC
TGATCACGGTGCTGTCTGCCATGACAGAGGAGGCAGCTGTTGCAATCAAGGCCATGGCAAAATAACTGGCTCCCAGGGTGGCGGTGGTGG
CAGCAGTGATCCTCTGAACCTGCAGAGGCCCCCTCCCCGAGCCTGGCCTGGCTCTGGCCCGGTCCTAAGCTGGACTCCTCCTACACAATT
TATTTGACGTTTTATTTTGGTTTTCCCCACCCCCTCAATCTGTCGGGGAGCCCCTGCCCTTCACCTAGCTCCCTTGGCCAGGAGCGAGCG
AAGCTGTGGCCTTGGTGAAGCTGCCCTCCTCTTCTCCCCTCACACTACAGCCCTGGTGGGGGAGAAGGGGGTGGGTGCTGCTTGTGGTTT
AGTCTTTTTTTTTTTTTTTTTTTTAATTCAATCTGGAATCAGAAAGCGGTGGATTCTGGCAAATGGTCCTTGTGCCCTCCCCACTCATCC
CTGGTCTGGTCCCCTGTTGCCTATAGCCCTTTACCCTGAGCACCACCCCAACAGACTGGGGACCAGCCCCCTCGCCTGCCTGTGTCTCTC
CCCAAACCCCTTTAGATGGGGAGGGAAGAGGAGGAGAGGGGAGGGGACCTGCCCCCTCCTCAGGCATCTGGGAGGGCCCTGCCCCCATGG

>In-frame_ENST00000372999_ENST00000336452_TCGA-J4-A67N-01A_TOX2_chr20_42635432_+_EIF5A_chr17_7212934_length(amino acids)=274AA_start in transcript=140_stop in transcript=964
MAESCGSVHFDGDSAYVGMSDGNPELLSTSQTYNGQSENNEDYEIPPITPPNLPEPSLLHLGDHEASYHSLCHGLTPNGLLPAYSYQAMD
LPAIMVSNMLAQDSHLLSGQLPTLESKPLKMADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVG
IDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIK

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>In-frame_ENST00000358131_ENST00000336452_TCGA-J4-A67N-01A_TOX2_chr20_42635432_+_EIF5A_chr17_7212934_length(transcript)=1777nt_BP=646nt
ACCAGGAGCTCCGAACACGCAGGCCCAAATTGGAATAGGAGATGGATTTTGATAAAAGAGGTTAAATAACAGGTTTTTCCATTTCACCTT
ATACGAATGGGATGGGGGGTGGGGGTGCTGGGCCTCCAGCCAATAGAGGACCAAGAGTTGTCAGGAGGGCTTATAAAGCTTGCTATTTCT
GGCATTTTTTCCTCTTTCTCTGCTGATTATGCAGCAGACTCGCACAGAGGCTGTCGCGGGCGCGTTCTCTCGCTGCCTGGGCTTCTGTGG
AATGAGACTCGGGCTCCTTCTACTTGCAAGACACTGGTGCATTGCAGGTGTGTTTCCGCAGAAGTTTGATGGTGACAGTGCCTACGTGGG
GATGAGTGACGGAAACCCAGAGCTCCTGTCAACCAGCCAGACCTACAACGGCCAGAGCGAGAACAACGAAGACTATGAGATCCCCCCGAT
AACACCTCCCAACCTCCCGGAGCCATCCCTCCTGCACCTGGGGGACCACGAAGCCAGCTACCACTCGCTGTGCCACGGCCTCACCCCCAA
CGGTCTGCTCCCTGCCTACTCCTATCAGGCCATGGACCTCCCAGCCATCATGGTGTCCAACATGCTAGCACAGGACAGCCACCTGCTGTC
GGGCCAGCTGCCCACGTTGGAATCGAAGCCTCTTAAAATGGCAGATGACTTGGACTTCGAGACAGGAGATGCAGGGGCCTCAGCCACCTT
CCCAATGCAGTGCTCAGCATTACGTAAGAATGGCTTTGTGGTGCTCAAAGGCCGGCCATGTAAGATCGTCGAGATGTCTACTTCGAAGAC
TGGCAAGCACGGCCACGCCAAGGTCCATCTGGTTGGTATTGACATCTTTACTGGGAAGAAATATGAAGATATCTGCCCGTCAACTCATAA
TATGGATGTCCCCAACATCAAAAGGAATGACTTCCAGCTGATTGGCATCCAGGATGGGTACCTATCACTGCTCCAGGACAGCGGGGAGGT
ACGAGAGGACCTTCGTCTCCCTGAGGGAGACCTTGGCAAGGAGATTGAGCAGAAGTACGACTGTGGAGAAGAGATCCTGATCACGGTGCT
GTCTGCCATGACAGAGGAGGCAGCTGTTGCAATCAAGGCCATGGCAAAATAACTGGCTCCCAGGGTGGCGGTGGTGGCAGCAGTGATCCT
CTGAACCTGCAGAGGCCCCCTCCCCGAGCCTGGCCTGGCTCTGGCCCGGTCCTAAGCTGGACTCCTCCTACACAATTTATTTGACGTTTT
ATTTTGGTTTTCCCCACCCCCTCAATCTGTCGGGGAGCCCCTGCCCTTCACCTAGCTCCCTTGGCCAGGAGCGAGCGAAGCTGTGGCCTT
GGTGAAGCTGCCCTCCTCTTCTCCCCTCACACTACAGCCCTGGTGGGGGAGAAGGGGGTGGGTGCTGCTTGTGGTTTAGTCTTTTTTTTT
TTTTTTTTTTTAATTCAATCTGGAATCAGAAAGCGGTGGATTCTGGCAAATGGTCCTTGTGCCCTCCCCACTCATCCCTGGTCTGGTCCC
CTGTTGCCTATAGCCCTTTACCCTGAGCACCACCCCAACAGACTGGGGACCAGCCCCCTCGCCTGCCTGTGTCTCTCCCCAAACCCCTTT
AGATGGGGAGGGAAGAGGAGGAGAGGGGAGGGGACCTGCCCCCTCCTCAGGCATCTGGGAGGGCCCTGCCCCCATGGGCTTTACCCTTCC

>In-frame_ENST00000358131_ENST00000336452_TCGA-J4-A67N-01A_TOX2_chr20_42635432_+_EIF5A_chr17_7212934_length(amino acids)=320AA_start in transcript=169_stop in transcript=1131
MLFLAFFPLSLLIMQQTRTEAVAGAFSRCLGFCGMRLGLLLLARHWCIAGVFPQKFDGDSAYVGMSDGNPELLSTSQTYNGQSENNEDYE
IPPITPPNLPEPSLLHLGDHEASYHSLCHGLTPNGLLPAYSYQAMDLPAIMVSNMLAQDSHLLSGQLPTLESKPLKMADDLDFETGDAGA
SATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQD

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Fusion Gene PPI Analysis for TOX2-EIF5A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TOX2-EIF5A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TOX2-EIF5A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneEIF5AC0007097Carcinoma1CTD_human
TgeneEIF5AC0022548Keloid1CTD_human
TgeneEIF5AC0024667Animal Mammary Neoplasms1CTD_human
TgeneEIF5AC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneEIF5AC0205696Anaplastic carcinoma1CTD_human
TgeneEIF5AC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneEIF5AC0205698Undifferentiated carcinoma1CTD_human
TgeneEIF5AC0205699Carcinomatosis1CTD_human
TgeneEIF5AC1257925Mammary Carcinoma, Animal1CTD_human