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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TP63-LEPREL1 (FusionGDB2 ID:92603)

Fusion Gene Summary for TP63-LEPREL1

check button Fusion gene summary
Fusion gene informationFusion gene name: TP63-LEPREL1
Fusion gene ID: 92603
HgeneTgene
Gene symbol

TP63

LEPREL1

Gene ID

8626

55214

Gene nametumor protein p63prolyl 3-hydroxylase 2
SynonymsAIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73LLEPREL1|MCVD|MLAT4
Cytomap

3q28

3q28

Type of geneprotein-codingprotein-coding
Descriptiontumor protein 63amplified in squamous cell carcinomachronic ulcerative stomatitis proteinkeratinocyte transcription factor KETtransformation-related protein 63tumor protein p53-competing proteinprolyl 3-hydroxylase 2leprecan-like 1myxoid liposarcoma-associated protein 4procollagen-proline 3-dioxygenase 2prolyl 3-hydroxylase 3
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264731, ENST00000382063, 
ENST00000418709, ENST00000320472, 
ENST00000392460, ENST00000440651, 
ENST00000354600, ENST00000437221, 
ENST00000392463, ENST00000392461, 
ENST00000456148, ENST00000449992, 
ENST00000319332, ENST00000427335, 
Fusion gene scores* DoF score6 X 6 X 4=1445 X 3 X 5=75
# samples 96
** MAII scorelog2(9/144*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TP63 [Title/Abstract] AND LEPREL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLEPREL1(189838041)-TP63(189526061), # samples:1
TP63(189526315)-LEPREL1(189713231), # samples:2
Anticipated loss of major functional domain due to fusion event.TP63-LEPREL1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
TP63-LEPREL1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TP63-LEPREL1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
TP63-LEPREL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTP63

GO:0045747

positive regulation of Notch signaling pathway

11641404

HgeneTP63

GO:0045892

negative regulation of transcription, DNA-templated

12446784

HgeneTP63

GO:0045893

positive regulation of transcription, DNA-templated

12446784|16343436

HgeneTP63

GO:0045944

positive regulation of transcription by RNA polymerase II

22521434

HgeneTP63

GO:2000271

positive regulation of fibroblast apoptotic process

9774969

TgeneLEPREL1

GO:0008285

negative regulation of cell proliferation

19436308

TgeneLEPREL1

GO:0019511

peptidyl-proline hydroxylation

18487197

TgeneLEPREL1

GO:0032963

collagen metabolic process

18487197


check buttonFusion gene breakpoints across TP63 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LEPREL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-39-5028TP63chr3

189507631

+LEPREL1chr3

189705458

-
ChimerDB4HNSCTCGA-CN-A49ATP63chr3

189526315

+LEPREL1chr3

189713231

-
ChimerDB4HNSCTCGA-CN-A49A-01ATP63chr3

189526315

-LEPREL1chr3

189713231

-


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Fusion Gene ORF analysis for TP63-LEPREL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000264731ENST00000319332TP63chr3

189507631

+LEPREL1chr3

189705458

-
intron-3CDSENST00000264731ENST00000427335TP63chr3

189507631

+LEPREL1chr3

189705458

-
intron-3CDSENST00000382063ENST00000319332TP63chr3

189507631

+LEPREL1chr3

189705458

-
intron-3CDSENST00000382063ENST00000427335TP63chr3

189507631

+LEPREL1chr3

189705458

-
intron-3CDSENST00000418709ENST00000319332TP63chr3

189507631

+LEPREL1chr3

189705458

-
intron-3CDSENST00000418709ENST00000427335TP63chr3

189507631

+LEPREL1chr3

189705458

-
intron-3CDSENST00000320472ENST00000319332TP63chr3

189507631

+LEPREL1chr3

189705458

-
intron-3CDSENST00000320472ENST00000427335TP63chr3

189507631

+LEPREL1chr3

189705458

-
intron-3CDSENST00000392460ENST00000319332TP63chr3

189507631

+LEPREL1chr3

189705458

-
intron-3CDSENST00000392460ENST00000427335TP63chr3

189507631

+LEPREL1chr3

189705458

-
intron-3CDSENST00000440651ENST00000319332TP63chr3

189507631

+LEPREL1chr3

189705458

-
intron-3CDSENST00000440651ENST00000427335TP63chr3

189507631

+LEPREL1chr3

189705458

-
Frame-shiftENST00000354600ENST00000319332TP63chr3

189507631

+LEPREL1chr3

189705458

-
Frame-shiftENST00000354600ENST00000427335TP63chr3

189507631

+LEPREL1chr3

189705458

-
Frame-shiftENST00000437221ENST00000319332TP63chr3

189507631

+LEPREL1chr3

189705458

-
Frame-shiftENST00000437221ENST00000427335TP63chr3

189507631

+LEPREL1chr3

189705458

-
Frame-shiftENST00000392463ENST00000319332TP63chr3

189507631

+LEPREL1chr3

189705458

-
Frame-shiftENST00000392463ENST00000427335TP63chr3

189507631

+LEPREL1chr3

189705458

-
Frame-shiftENST00000392461ENST00000319332TP63chr3

189507631

+LEPREL1chr3

189705458

-
Frame-shiftENST00000392461ENST00000427335TP63chr3

189507631

+LEPREL1chr3

189705458

-
Frame-shiftENST00000456148ENST00000319332TP63chr3

189507631

+LEPREL1chr3

189705458

-
Frame-shiftENST00000456148ENST00000427335TP63chr3

189507631

+LEPREL1chr3

189705458

-
Frame-shiftENST00000449992ENST00000319332TP63chr3

189507631

+LEPREL1chr3

189705458

-
Frame-shiftENST00000449992ENST00000427335TP63chr3

189507631

+LEPREL1chr3

189705458

-
In-frameENST00000264731ENST00000319332TP63chr3

189526315

+LEPREL1chr3

189713231

-
5CDS-5UTRENST00000264731ENST00000427335TP63chr3

189526315

+LEPREL1chr3

189713231

-
intron-3CDSENST00000382063ENST00000319332TP63chr3

189526315

+LEPREL1chr3

189713231

-
intron-5UTRENST00000382063ENST00000427335TP63chr3

189526315

+LEPREL1chr3

189713231

-
In-frameENST00000418709ENST00000319332TP63chr3

189526315

+LEPREL1chr3

189713231

-
5CDS-5UTRENST00000418709ENST00000427335TP63chr3

189526315

+LEPREL1chr3

189713231

-
In-frameENST00000320472ENST00000319332TP63chr3

189526315

+LEPREL1chr3

189713231

-
5CDS-5UTRENST00000320472ENST00000427335TP63chr3

189526315

+LEPREL1chr3

189713231

-
In-frameENST00000392460ENST00000319332TP63chr3

189526315

+LEPREL1chr3

189713231

-
5CDS-5UTRENST00000392460ENST00000427335TP63chr3

189526315

+LEPREL1chr3

189713231

-
In-frameENST00000440651ENST00000319332TP63chr3

189526315

+LEPREL1chr3

189713231

-
5CDS-5UTRENST00000440651ENST00000427335TP63chr3

189526315

+LEPREL1chr3

189713231

-
In-frameENST00000354600ENST00000319332TP63chr3

189526315

+LEPREL1chr3

189713231

-
5CDS-5UTRENST00000354600ENST00000427335TP63chr3

189526315

+LEPREL1chr3

189713231

-
In-frameENST00000437221ENST00000319332TP63chr3

189526315

+LEPREL1chr3

189713231

-
5CDS-5UTRENST00000437221ENST00000427335TP63chr3

189526315

+LEPREL1chr3

189713231

-
In-frameENST00000392463ENST00000319332TP63chr3

189526315

+LEPREL1chr3

189713231

-
5CDS-5UTRENST00000392463ENST00000427335TP63chr3

189526315

+LEPREL1chr3

189713231

-
In-frameENST00000392461ENST00000319332TP63chr3

189526315

+LEPREL1chr3

189713231

-
5CDS-5UTRENST00000392461ENST00000427335TP63chr3

189526315

+LEPREL1chr3

189713231

-
In-frameENST00000456148ENST00000319332TP63chr3

189526315

+LEPREL1chr3

189713231

-
5CDS-5UTRENST00000456148ENST00000427335TP63chr3

189526315

+LEPREL1chr3

189713231

-
intron-3CDSENST00000449992ENST00000319332TP63chr3

189526315

+LEPREL1chr3

189713231

-
intron-5UTRENST00000449992ENST00000427335TP63chr3

189526315

+LEPREL1chr3

189713231

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264731TP63chr3189526315+ENST00000319332LEPREL1chr3189713231-3499668802314744
ENST00000418709TP63chr3189526315+ENST00000319332LEPREL1chr3189713231-3438607192253744
ENST00000320472TP63chr3189526315+ENST00000319332LEPREL1chr3189713231-3438607192253744
ENST00000392460TP63chr3189526315+ENST00000319332LEPREL1chr3189713231-341057902225741
ENST00000440651TP63chr3189526315+ENST00000319332LEPREL1chr3189713231-341057902225741
ENST00000354600TP63chr3189526315+ENST00000319332LEPREL1chr3189713231-3269438932084663
ENST00000437221TP63chr3189526315+ENST00000319332LEPREL1chr3189713231-312829701943647
ENST00000392463TP63chr3189526315+ENST00000319332LEPREL1chr3189713231-312829701943647
ENST00000392461TP63chr3189526315+ENST00000319332LEPREL1chr3189713231-312829701943647
ENST00000456148TP63chr3189526315+ENST00000319332LEPREL1chr3189713231-312829701943647

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264731ENST00000319332TP63chr3189526315+LEPREL1chr3189713231-0.0010822270.9989178
ENST00000418709ENST00000319332TP63chr3189526315+LEPREL1chr3189713231-0.0013358650.99866414
ENST00000320472ENST00000319332TP63chr3189526315+LEPREL1chr3189713231-0.0013358650.99866414
ENST00000392460ENST00000319332TP63chr3189526315+LEPREL1chr3189713231-0.0013649970.998635
ENST00000440651ENST00000319332TP63chr3189526315+LEPREL1chr3189713231-0.0013649970.998635
ENST00000354600ENST00000319332TP63chr3189526315+LEPREL1chr3189713231-0.0010080140.998992
ENST00000437221ENST00000319332TP63chr3189526315+LEPREL1chr3189713231-0.00110780.99889225
ENST00000392463ENST00000319332TP63chr3189526315+LEPREL1chr3189713231-0.00110780.99889225
ENST00000392461ENST00000319332TP63chr3189526315+LEPREL1chr3189713231-0.00110780.99889225
ENST00000456148ENST00000319332TP63chr3189526315+LEPREL1chr3189713231-0.00110780.99889225

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Fusion Genomic Features for TP63-LEPREL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TP63-LEPREL1


check button Go to

FGviewer for the breakpoints of chr3:189526315-chr3:189713231

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTP63chr3:189526315chr3:189713231ENST00000264731+4141_107193.0681.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000320472+4121_107193.0511.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000392460+4131_107193.0556.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000418709+4111_107193.0488.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000440651+4141_107193.0677.0RegionNote=Transcription activation
TgeneLEPREL1chr3:189526315chr3:189713231ENST00000319332015557_671160.0709.0DomainFe2OG dioxygenase
TgeneLEPREL1chr3:189526315chr3:189713231ENST00000319332015705_708160.0709.0MotifPrevents secretion from ER
TgeneLEPREL1chr3:189526315chr3:189713231ENST00000319332015210_243160.0709.0RepeatNote=TPR 3
TgeneLEPREL1chr3:189526315chr3:189713231ENST00000319332015306_339160.0709.0RepeatNote=TPR 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTP63chr3:189526315chr3:189713231ENST00000264731+414437_444193.0681.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000320472+412437_444193.0511.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000354600+212437_44499.0587.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000382063+113437_4440596.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000392460+413437_444193.0556.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000392461+210437_44499.0417.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000392463+211437_44499.0462.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000418709+411437_444193.0488.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000437221+29437_44499.0394.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000440651+414437_444193.0677.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000449992+111437_4440.0502.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000456148+212437_44499.0583.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000264731+414170_362193.0681.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000320472+412170_362193.0511.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000354600+212170_36299.0587.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000382063+113170_3620596.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000392460+413170_362193.0556.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000392461+210170_36299.0417.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000392463+211170_36299.0462.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000418709+411170_362193.0488.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000437221+29170_36299.0394.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000440651+414170_362193.0677.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000449992+111170_3620.0502.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000456148+212170_36299.0583.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000264731+414541_607193.0681.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000320472+412541_607193.0511.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000354600+212541_60799.0587.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000382063+113541_6070596.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000392460+413541_607193.0556.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000392461+210541_60799.0417.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000392463+211541_60799.0462.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000418709+411541_607193.0488.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000437221+29541_60799.0394.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000440651+414541_607193.0677.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000449992+111541_6070.0502.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000456148+212541_60799.0583.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000264731+414394_443193.0681.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000264731+414610_680193.0681.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000320472+412394_443193.0511.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000320472+412610_680193.0511.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000354600+2121_10799.0587.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000354600+212394_44399.0587.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000354600+212610_68099.0587.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000382063+1131_1070596.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000382063+113394_4430596.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000382063+113610_6800596.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000392460+413394_443193.0556.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000392460+413610_680193.0556.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000392461+2101_10799.0417.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000392461+210394_44399.0417.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000392461+210610_68099.0417.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000392463+2111_10799.0462.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000392463+211394_44399.0462.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000392463+211610_68099.0462.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000418709+411394_443193.0488.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000418709+411610_680193.0488.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000437221+291_10799.0394.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000437221+29394_44399.0394.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000437221+29610_68099.0394.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000440651+414394_443193.0677.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000440651+414610_680193.0677.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000449992+1111_1070.0502.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000449992+111394_4430.0502.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000449992+111610_6800.0502.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000456148+2121_10799.0583.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000456148+212394_44399.0583.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000456148+212610_68099.0583.0RegionNote=Transactivation inhibition
TgeneLEPREL1chr3:189526315chr3:189713231ENST0000031933201593_99160.0709.0Compositional biasNote=Poly-Pro
TgeneLEPREL1chr3:189526315chr3:189713231ENST00000319332015148_181160.0709.0RepeatNote=TPR 2
TgeneLEPREL1chr3:189526315chr3:189713231ENST0000031933201544_77160.0709.0RepeatNote=TPR 1


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Fusion Gene Sequence for TP63-LEPREL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000264731_ENST00000319332_TCGA-CN-A49A_TP63_chr3_189526315_+_LEPREL1_chr3_189713231_length(transcript)=3499nt_BP=668nt
CCCGGCTTTATATCTATATATACACAGGTATATGTGTATATTTTATATAATTGTTCTCCGTTCGTTGATATCAAAGACAGTTGAAGGAAA
TGAATTTTGAAACTTCACGGTGTGCCACCCTACAGTACTGCCCTGACCCTTACATCCAGCGTTTCGTAGAAACCCCAGCTCATTTCTCTT
GGAAAGAAAGTTATTACCGATCCACCATGTCCCAGAGCACACAGACAAATGAATTCCTCAGTCCAGAGGTTTTCCAGCATATCTGGGATT
TTCTGGAACAGCCTATATGTTCAGTTCAGCCCATTGACTTGAACTTTGTGGATGAACCATCAGAAGATGGTGCGACAAACAAGATTGAGA
TTAGCATGGACTGTATCCGCATGCAGGACTCGGACCTGAGTGACCCCATGTGGCCACAGTACACGAACCTGGGGCTCCTGAACAGCATGG
ACCAGCAGATTCAGAACGGCTCCTCGTCCACCAGTCCCTATAACACAGACCACGCGCAGAACAGCGTCACGGCGCCCTCGCCCTACGCAC
AGCCCAGCTCCACCTTCGATGCTCTCTCTCCATCACCCGCCATCCCCTCCAACACCGACTACCCAGGCCCGCACAGTTTCGACGTGTCCT
TCCAGCAGTCGAGCACCGCCAAGTCGGCCACCTGGACGCTTAACCAGCTCGAAAAAGCAGTGGAAGCAGCTCACACATTTTTCGTGGCTA
ACCCTGAGCACATGGAAATGCAGCAGAACATTGAGAATTACAGGGCGACAGCTGGTGTTGAAGCATTGCAGTTGGTAGACAGAGAAGCCA
AGCCACACATGGAGAGTTACAATGCAGGAGTTAAACATTATGAGGCTGATGACTTTGAGATGGCTATCAGGCACTTCGAACAAGCCTTAA
GAGAATATTTCGTTGAAGATACAGAATGCCGGACCCTATGTGAGGGGCCTCAGAGATTTGAAGAATATGAGTATTTAGGGTATAAGGCTG
GTCTGTATGAAGCTATTGCAGATCACTACATGCAGGTGCTTGTTTGTCAGCATGAATGTGTGAGGGAACTTGCCACCCGCCCTGGCCGCC
TCTCTCCCATCGAGAATTTTCTTCCTCTGCACTATGATTACCTACAGTTTGCCTACTATCGAGTTGGTGAGTATGTGAAAGCCCTGGAGT
GTGCCAAAGCCTATCTTCTATGCCATCCAGATGATGAGGATGTCCTAGACAATGTGGATTACTATGAGAGTCTGCTGGATGATAGCATTG
ACCCGGCATCCATTGAGGCCAGAGAGGATTTAACAATGTTTGTGAAACGTCATAAGCTGGAGTCTGAGCTGATAAAATCAGCTGCAGAAG
GTCTGGGGTTTTCATACACTGAACCGAATTATTGGATCAGATATGGAGGACGACAGGATGAGAATCGGGTCCCTTCAGGAGTGAACGTAG
AGGGAGCAGAAGTTCATGGATTCTCAATGGGAAAAAAGCTATCACCCAAGATAGATCGAGACCTAAGAGAAGGTGGTCCTCTACTCTATG
AGAACATCACATTCGTCTACAACTCGGAGCAGCTGAACGGGACTCAGCGGGTTCTCCTGGATAACGTCCTGTCGGAAGAACAGTGCCGGG
AGCTCCACAGCGTGGCCAGTGGAATCATGCTTGTTGGTGATGGATACAGAGGAAAAACTTCACCCCATACACCCAATGAAAAGTTTGAAG
GTGCAACTGTCCTGAAAGCACTCAAATCTGGTTATGAAGGTCGAGTCCCACTGAAGAGCGCTCGTCTGTTTTATGACATCAGCGAAAAGG
CTCGAAGGATTGTAGAATCTTATTTTATGCTGAACTCAACTCTGTATTTTTCCTATACACACATGGTCTGCCGAACAGCCCTGTCTGGTC
AGCAGGATAGAAGAAATGACCTCAGTCATCCCATCCATGCTGACAACTGTTTGTTGGATCCAGAGGCCAACGAATGCTGGAAGGAGCCTC
CTGCTTACACATTTCGAGACTATAGTGCTCTCCTATATATGAATGATGACTTTGAAGGAGGAGAATTCATATTCACAGAGATGGATGCTA
AGACTGTGACTGCCTCTATAAAACCAAAATGTGGGCGCATGATCAGCTTCTCATCTGGAGGAGAGAACCCTCATGGGGTGAAGGCAGTCA
CCAAGGGAAAGAGGTGTGCTGTGGCTCTGTGGTTCACCTTGGACCCACTTTATAGAGAATTGGAGCGAATACAGGCTGATGAAGTGATTG
CAATTCTGGATCAAGAACAGCAAGGGAAGCATGAACTGAATATCAACCCTAAAGATGAGCTATAAAAATGAGAAAGAATGTTCTATCAAA
TATTTATTTAAATTGTTAATCTTATGAGAACCTTTTTATTTTTGTACAGAGCCATGGTATAAATTAACAGGTTAATGTCAGTCATCAGAT
CTTCCTTCTCTTCCTAAGGATGCTTGTGTTGCCTCAATCTATCAATCTATCTTTCTTGTTTTGGGTTGTTTTCTCTCTCTCTCTCTCTCT
CTCTCTTCTTAGAGACATGGTCTAACCATGTTGTCTAGGATATAGGGCAGTGGCTATTCACAGATGTGATGATAGCACACTGGAGCCTCA
AACTCTTAGGCTCAGGCGATCCTTCAAGCCTCCCGGGGAGCTGGGACCACAGGCACGTGCCACCACACCCAGCTCTCTTTCTTGGTTTTT
CATCATTTCATGTATCTATCAAAGCCCAGTTCACCTCCTCCCCCAAACACACACACACACACACACACACACACACACACACACAATTAA
GTTGCTGCAAATTCAAAAGCTTAGAGAGAATAAGCTTCTTGGTGGTGAAACTACAACTCTCACGTGTGCTCCAGTTCTAAAATTAACCTG
TGCCTGGTCTCTGAAGCCCTTTCTTGCTCTGTGCCTTTCAGCCACATCCTTAGGTGCTAACGGCCATGAGCTCCGACTCTCCAAAGTGAG
CTCCACTTTGGGTCTGAGGAGCCCCTGGCAGAGTCCACGCTGCCTCAGGTATCATGGGCGTAATGATCACCCAGGCTCCGGGAGATCTCA
TGGATGATTACTGTATGAGACAGAGGGGACTTCAGTCTTTCCAGGGCCTTGGTGGAATTTTTGGCTCTGGTGTTTTCGCCAGACAATAAA
CTTACACTGGAAGCTTTGATTCACCCTCCACAGTACTCCAGAAAGGACTGTCCTATAAGTTGTACACTTTAAAAGGTCATGTAGAGGTTG
TAGTAGAATGGCTTTTCACCCTGGTGACTTTGGAAGAAACTCTTGAATACTGCCTGCATCCGGGCACCATGGCCAGGTTGCCTAGGAGTG
GGGTCCACTGATGAAAAGAGGTGTTTTGTACTTACATAAGAAAAATAAATTTCTGATTGATTTTAACCGTCATCTGCTTATATTTTGGGG

>In-frame_ENST00000264731_ENST00000319332_TCGA-CN-A49A_TP63_chr3_189526315_+_LEPREL1_chr3_189713231_length(amino acids)=744AA_start in transcript=80_stop in transcript=2314
MKEMNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATN
KIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSF
DVSFQQSSTAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFE
QALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVK
ALECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSG
VNVEGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNE
KFEGATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECW
KEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQAD

--------------------------------------------------------------
>In-frame_ENST00000418709_ENST00000319332_TCGA-CN-A49A_TP63_chr3_189526315_+_LEPREL1_chr3_189713231_length(transcript)=3438nt_BP=607nt
TCGTTGATATCAAAGACAGTTGAAGGAAATGAATTTTGAAACTTCACGGTGTGCCACCCTACAGTACTGCCCTGACCCTTACATCCAGCG
TTTCGTAGAAACCCCAGCTCATTTCTCTTGGAAAGAAAGTTATTACCGATCCACCATGTCCCAGAGCACACAGACAAATGAATTCCTCAG
TCCAGAGGTTTTCCAGCATATCTGGGATTTTCTGGAACAGCCTATATGTTCAGTTCAGCCCATTGACTTGAACTTTGTGGATGAACCATC
AGAAGATGGTGCGACAAACAAGATTGAGATTAGCATGGACTGTATCCGCATGCAGGACTCGGACCTGAGTGACCCCATGTGGCCACAGTA
CACGAACCTGGGGCTCCTGAACAGCATGGACCAGCAGATTCAGAACGGCTCCTCGTCCACCAGTCCCTATAACACAGACCACGCGCAGAA
CAGCGTCACGGCGCCCTCGCCCTACGCACAGCCCAGCTCCACCTTCGATGCTCTCTCTCCATCACCCGCCATCCCCTCCAACACCGACTA
CCCAGGCCCGCACAGTTTCGACGTGTCCTTCCAGCAGTCGAGCACCGCCAAGTCGGCCACCTGGACGCTTAACCAGCTCGAAAAAGCAGT
GGAAGCAGCTCACACATTTTTCGTGGCTAACCCTGAGCACATGGAAATGCAGCAGAACATTGAGAATTACAGGGCGACAGCTGGTGTTGA
AGCATTGCAGTTGGTAGACAGAGAAGCCAAGCCACACATGGAGAGTTACAATGCAGGAGTTAAACATTATGAGGCTGATGACTTTGAGAT
GGCTATCAGGCACTTCGAACAAGCCTTAAGAGAATATTTCGTTGAAGATACAGAATGCCGGACCCTATGTGAGGGGCCTCAGAGATTTGA
AGAATATGAGTATTTAGGGTATAAGGCTGGTCTGTATGAAGCTATTGCAGATCACTACATGCAGGTGCTTGTTTGTCAGCATGAATGTGT
GAGGGAACTTGCCACCCGCCCTGGCCGCCTCTCTCCCATCGAGAATTTTCTTCCTCTGCACTATGATTACCTACAGTTTGCCTACTATCG
AGTTGGTGAGTATGTGAAAGCCCTGGAGTGTGCCAAAGCCTATCTTCTATGCCATCCAGATGATGAGGATGTCCTAGACAATGTGGATTA
CTATGAGAGTCTGCTGGATGATAGCATTGACCCGGCATCCATTGAGGCCAGAGAGGATTTAACAATGTTTGTGAAACGTCATAAGCTGGA
GTCTGAGCTGATAAAATCAGCTGCAGAAGGTCTGGGGTTTTCATACACTGAACCGAATTATTGGATCAGATATGGAGGACGACAGGATGA
GAATCGGGTCCCTTCAGGAGTGAACGTAGAGGGAGCAGAAGTTCATGGATTCTCAATGGGAAAAAAGCTATCACCCAAGATAGATCGAGA
CCTAAGAGAAGGTGGTCCTCTACTCTATGAGAACATCACATTCGTCTACAACTCGGAGCAGCTGAACGGGACTCAGCGGGTTCTCCTGGA
TAACGTCCTGTCGGAAGAACAGTGCCGGGAGCTCCACAGCGTGGCCAGTGGAATCATGCTTGTTGGTGATGGATACAGAGGAAAAACTTC
ACCCCATACACCCAATGAAAAGTTTGAAGGTGCAACTGTCCTGAAAGCACTCAAATCTGGTTATGAAGGTCGAGTCCCACTGAAGAGCGC
TCGTCTGTTTTATGACATCAGCGAAAAGGCTCGAAGGATTGTAGAATCTTATTTTATGCTGAACTCAACTCTGTATTTTTCCTATACACA
CATGGTCTGCCGAACAGCCCTGTCTGGTCAGCAGGATAGAAGAAATGACCTCAGTCATCCCATCCATGCTGACAACTGTTTGTTGGATCC
AGAGGCCAACGAATGCTGGAAGGAGCCTCCTGCTTACACATTTCGAGACTATAGTGCTCTCCTATATATGAATGATGACTTTGAAGGAGG
AGAATTCATATTCACAGAGATGGATGCTAAGACTGTGACTGCCTCTATAAAACCAAAATGTGGGCGCATGATCAGCTTCTCATCTGGAGG
AGAGAACCCTCATGGGGTGAAGGCAGTCACCAAGGGAAAGAGGTGTGCTGTGGCTCTGTGGTTCACCTTGGACCCACTTTATAGAGAATT
GGAGCGAATACAGGCTGATGAAGTGATTGCAATTCTGGATCAAGAACAGCAAGGGAAGCATGAACTGAATATCAACCCTAAAGATGAGCT
ATAAAAATGAGAAAGAATGTTCTATCAAATATTTATTTAAATTGTTAATCTTATGAGAACCTTTTTATTTTTGTACAGAGCCATGGTATA
AATTAACAGGTTAATGTCAGTCATCAGATCTTCCTTCTCTTCCTAAGGATGCTTGTGTTGCCTCAATCTATCAATCTATCTTTCTTGTTT
TGGGTTGTTTTCTCTCTCTCTCTCTCTCTCTCTCTTCTTAGAGACATGGTCTAACCATGTTGTCTAGGATATAGGGCAGTGGCTATTCAC
AGATGTGATGATAGCACACTGGAGCCTCAAACTCTTAGGCTCAGGCGATCCTTCAAGCCTCCCGGGGAGCTGGGACCACAGGCACGTGCC
ACCACACCCAGCTCTCTTTCTTGGTTTTTCATCATTTCATGTATCTATCAAAGCCCAGTTCACCTCCTCCCCCAAACACACACACACACA
CACACACACACACACACACACACAATTAAGTTGCTGCAAATTCAAAAGCTTAGAGAGAATAAGCTTCTTGGTGGTGAAACTACAACTCTC
ACGTGTGCTCCAGTTCTAAAATTAACCTGTGCCTGGTCTCTGAAGCCCTTTCTTGCTCTGTGCCTTTCAGCCACATCCTTAGGTGCTAAC
GGCCATGAGCTCCGACTCTCCAAAGTGAGCTCCACTTTGGGTCTGAGGAGCCCCTGGCAGAGTCCACGCTGCCTCAGGTATCATGGGCGT
AATGATCACCCAGGCTCCGGGAGATCTCATGGATGATTACTGTATGAGACAGAGGGGACTTCAGTCTTTCCAGGGCCTTGGTGGAATTTT
TGGCTCTGGTGTTTTCGCCAGACAATAAACTTACACTGGAAGCTTTGATTCACCCTCCACAGTACTCCAGAAAGGACTGTCCTATAAGTT
GTACACTTTAAAAGGTCATGTAGAGGTTGTAGTAGAATGGCTTTTCACCCTGGTGACTTTGGAAGAAACTCTTGAATACTGCCTGCATCC
GGGCACCATGGCCAGGTTGCCTAGGAGTGGGGTCCACTGATGAAAAGAGGTGTTTTGTACTTACATAAGAAAAATAAATTTCTGATTGAT
TTTAACCGTCATCTGCTTATATTTTGGGGGCCCCTCCTCATTGCTGCTATCCAGCACACAGATTTGTGCTTGTGTCTGATTTGTTTAATA

>In-frame_ENST00000418709_ENST00000319332_TCGA-CN-A49A_TP63_chr3_189526315_+_LEPREL1_chr3_189713231_length(amino acids)=744AA_start in transcript=19_stop in transcript=2253
MKEMNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATN
KIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSF
DVSFQQSSTAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFE
QALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVK
ALECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSG
VNVEGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNE
KFEGATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECW
KEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQAD

--------------------------------------------------------------
>In-frame_ENST00000320472_ENST00000319332_TCGA-CN-A49A_TP63_chr3_189526315_+_LEPREL1_chr3_189713231_length(transcript)=3438nt_BP=607nt
TCGTTGATATCAAAGACAGTTGAAGGAAATGAATTTTGAAACTTCACGGTGTGCCACCCTACAGTACTGCCCTGACCCTTACATCCAGCG
TTTCGTAGAAACCCCAGCTCATTTCTCTTGGAAAGAAAGTTATTACCGATCCACCATGTCCCAGAGCACACAGACAAATGAATTCCTCAG
TCCAGAGGTTTTCCAGCATATCTGGGATTTTCTGGAACAGCCTATATGTTCAGTTCAGCCCATTGACTTGAACTTTGTGGATGAACCATC
AGAAGATGGTGCGACAAACAAGATTGAGATTAGCATGGACTGTATCCGCATGCAGGACTCGGACCTGAGTGACCCCATGTGGCCACAGTA
CACGAACCTGGGGCTCCTGAACAGCATGGACCAGCAGATTCAGAACGGCTCCTCGTCCACCAGTCCCTATAACACAGACCACGCGCAGAA
CAGCGTCACGGCGCCCTCGCCCTACGCACAGCCCAGCTCCACCTTCGATGCTCTCTCTCCATCACCCGCCATCCCCTCCAACACCGACTA
CCCAGGCCCGCACAGTTTCGACGTGTCCTTCCAGCAGTCGAGCACCGCCAAGTCGGCCACCTGGACGCTTAACCAGCTCGAAAAAGCAGT
GGAAGCAGCTCACACATTTTTCGTGGCTAACCCTGAGCACATGGAAATGCAGCAGAACATTGAGAATTACAGGGCGACAGCTGGTGTTGA
AGCATTGCAGTTGGTAGACAGAGAAGCCAAGCCACACATGGAGAGTTACAATGCAGGAGTTAAACATTATGAGGCTGATGACTTTGAGAT
GGCTATCAGGCACTTCGAACAAGCCTTAAGAGAATATTTCGTTGAAGATACAGAATGCCGGACCCTATGTGAGGGGCCTCAGAGATTTGA
AGAATATGAGTATTTAGGGTATAAGGCTGGTCTGTATGAAGCTATTGCAGATCACTACATGCAGGTGCTTGTTTGTCAGCATGAATGTGT
GAGGGAACTTGCCACCCGCCCTGGCCGCCTCTCTCCCATCGAGAATTTTCTTCCTCTGCACTATGATTACCTACAGTTTGCCTACTATCG
AGTTGGTGAGTATGTGAAAGCCCTGGAGTGTGCCAAAGCCTATCTTCTATGCCATCCAGATGATGAGGATGTCCTAGACAATGTGGATTA
CTATGAGAGTCTGCTGGATGATAGCATTGACCCGGCATCCATTGAGGCCAGAGAGGATTTAACAATGTTTGTGAAACGTCATAAGCTGGA
GTCTGAGCTGATAAAATCAGCTGCAGAAGGTCTGGGGTTTTCATACACTGAACCGAATTATTGGATCAGATATGGAGGACGACAGGATGA
GAATCGGGTCCCTTCAGGAGTGAACGTAGAGGGAGCAGAAGTTCATGGATTCTCAATGGGAAAAAAGCTATCACCCAAGATAGATCGAGA
CCTAAGAGAAGGTGGTCCTCTACTCTATGAGAACATCACATTCGTCTACAACTCGGAGCAGCTGAACGGGACTCAGCGGGTTCTCCTGGA
TAACGTCCTGTCGGAAGAACAGTGCCGGGAGCTCCACAGCGTGGCCAGTGGAATCATGCTTGTTGGTGATGGATACAGAGGAAAAACTTC
ACCCCATACACCCAATGAAAAGTTTGAAGGTGCAACTGTCCTGAAAGCACTCAAATCTGGTTATGAAGGTCGAGTCCCACTGAAGAGCGC
TCGTCTGTTTTATGACATCAGCGAAAAGGCTCGAAGGATTGTAGAATCTTATTTTATGCTGAACTCAACTCTGTATTTTTCCTATACACA
CATGGTCTGCCGAACAGCCCTGTCTGGTCAGCAGGATAGAAGAAATGACCTCAGTCATCCCATCCATGCTGACAACTGTTTGTTGGATCC
AGAGGCCAACGAATGCTGGAAGGAGCCTCCTGCTTACACATTTCGAGACTATAGTGCTCTCCTATATATGAATGATGACTTTGAAGGAGG
AGAATTCATATTCACAGAGATGGATGCTAAGACTGTGACTGCCTCTATAAAACCAAAATGTGGGCGCATGATCAGCTTCTCATCTGGAGG
AGAGAACCCTCATGGGGTGAAGGCAGTCACCAAGGGAAAGAGGTGTGCTGTGGCTCTGTGGTTCACCTTGGACCCACTTTATAGAGAATT
GGAGCGAATACAGGCTGATGAAGTGATTGCAATTCTGGATCAAGAACAGCAAGGGAAGCATGAACTGAATATCAACCCTAAAGATGAGCT
ATAAAAATGAGAAAGAATGTTCTATCAAATATTTATTTAAATTGTTAATCTTATGAGAACCTTTTTATTTTTGTACAGAGCCATGGTATA
AATTAACAGGTTAATGTCAGTCATCAGATCTTCCTTCTCTTCCTAAGGATGCTTGTGTTGCCTCAATCTATCAATCTATCTTTCTTGTTT
TGGGTTGTTTTCTCTCTCTCTCTCTCTCTCTCTCTTCTTAGAGACATGGTCTAACCATGTTGTCTAGGATATAGGGCAGTGGCTATTCAC
AGATGTGATGATAGCACACTGGAGCCTCAAACTCTTAGGCTCAGGCGATCCTTCAAGCCTCCCGGGGAGCTGGGACCACAGGCACGTGCC
ACCACACCCAGCTCTCTTTCTTGGTTTTTCATCATTTCATGTATCTATCAAAGCCCAGTTCACCTCCTCCCCCAAACACACACACACACA
CACACACACACACACACACACACAATTAAGTTGCTGCAAATTCAAAAGCTTAGAGAGAATAAGCTTCTTGGTGGTGAAACTACAACTCTC
ACGTGTGCTCCAGTTCTAAAATTAACCTGTGCCTGGTCTCTGAAGCCCTTTCTTGCTCTGTGCCTTTCAGCCACATCCTTAGGTGCTAAC
GGCCATGAGCTCCGACTCTCCAAAGTGAGCTCCACTTTGGGTCTGAGGAGCCCCTGGCAGAGTCCACGCTGCCTCAGGTATCATGGGCGT
AATGATCACCCAGGCTCCGGGAGATCTCATGGATGATTACTGTATGAGACAGAGGGGACTTCAGTCTTTCCAGGGCCTTGGTGGAATTTT
TGGCTCTGGTGTTTTCGCCAGACAATAAACTTACACTGGAAGCTTTGATTCACCCTCCACAGTACTCCAGAAAGGACTGTCCTATAAGTT
GTACACTTTAAAAGGTCATGTAGAGGTTGTAGTAGAATGGCTTTTCACCCTGGTGACTTTGGAAGAAACTCTTGAATACTGCCTGCATCC
GGGCACCATGGCCAGGTTGCCTAGGAGTGGGGTCCACTGATGAAAAGAGGTGTTTTGTACTTACATAAGAAAAATAAATTTCTGATTGAT
TTTAACCGTCATCTGCTTATATTTTGGGGGCCCCTCCTCATTGCTGCTATCCAGCACACAGATTTGTGCTTGTGTCTGATTTGTTTAATA

>In-frame_ENST00000320472_ENST00000319332_TCGA-CN-A49A_TP63_chr3_189526315_+_LEPREL1_chr3_189713231_length(amino acids)=744AA_start in transcript=19_stop in transcript=2253
MKEMNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATN
KIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSF
DVSFQQSSTAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFE
QALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVK
ALECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSG
VNVEGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNE
KFEGATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECW
KEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQAD

--------------------------------------------------------------
>In-frame_ENST00000392460_ENST00000319332_TCGA-CN-A49A_TP63_chr3_189526315_+_LEPREL1_chr3_189713231_length(transcript)=3410nt_BP=579nt
ATGAATTTTGAAACTTCACGGTGTGCCACCCTACAGTACTGCCCTGACCCTTACATCCAGCGTTTCGTAGAAACCCCAGCTCATTTCTCT
TGGAAAGAAAGTTATTACCGATCCACCATGTCCCAGAGCACACAGACAAATGAATTCCTCAGTCCAGAGGTTTTCCAGCATATCTGGGAT
TTTCTGGAACAGCCTATATGTTCAGTTCAGCCCATTGACTTGAACTTTGTGGATGAACCATCAGAAGATGGTGCGACAAACAAGATTGAG
ATTAGCATGGACTGTATCCGCATGCAGGACTCGGACCTGAGTGACCCCATGTGGCCACAGTACACGAACCTGGGGCTCCTGAACAGCATG
GACCAGCAGATTCAGAACGGCTCCTCGTCCACCAGTCCCTATAACACAGACCACGCGCAGAACAGCGTCACGGCGCCCTCGCCCTACGCA
CAGCCCAGCTCCACCTTCGATGCTCTCTCTCCATCACCCGCCATCCCCTCCAACACCGACTACCCAGGCCCGCACAGTTTCGACGTGTCC
TTCCAGCAGTCGAGCACCGCCAAGTCGGCCACCTGGACGCTTAACCAGCTCGAAAAAGCAGTGGAAGCAGCTCACACATTTTTCGTGGCT
AACCCTGAGCACATGGAAATGCAGCAGAACATTGAGAATTACAGGGCGACAGCTGGTGTTGAAGCATTGCAGTTGGTAGACAGAGAAGCC
AAGCCACACATGGAGAGTTACAATGCAGGAGTTAAACATTATGAGGCTGATGACTTTGAGATGGCTATCAGGCACTTCGAACAAGCCTTA
AGAGAATATTTCGTTGAAGATACAGAATGCCGGACCCTATGTGAGGGGCCTCAGAGATTTGAAGAATATGAGTATTTAGGGTATAAGGCT
GGTCTGTATGAAGCTATTGCAGATCACTACATGCAGGTGCTTGTTTGTCAGCATGAATGTGTGAGGGAACTTGCCACCCGCCCTGGCCGC
CTCTCTCCCATCGAGAATTTTCTTCCTCTGCACTATGATTACCTACAGTTTGCCTACTATCGAGTTGGTGAGTATGTGAAAGCCCTGGAG
TGTGCCAAAGCCTATCTTCTATGCCATCCAGATGATGAGGATGTCCTAGACAATGTGGATTACTATGAGAGTCTGCTGGATGATAGCATT
GACCCGGCATCCATTGAGGCCAGAGAGGATTTAACAATGTTTGTGAAACGTCATAAGCTGGAGTCTGAGCTGATAAAATCAGCTGCAGAA
GGTCTGGGGTTTTCATACACTGAACCGAATTATTGGATCAGATATGGAGGACGACAGGATGAGAATCGGGTCCCTTCAGGAGTGAACGTA
GAGGGAGCAGAAGTTCATGGATTCTCAATGGGAAAAAAGCTATCACCCAAGATAGATCGAGACCTAAGAGAAGGTGGTCCTCTACTCTAT
GAGAACATCACATTCGTCTACAACTCGGAGCAGCTGAACGGGACTCAGCGGGTTCTCCTGGATAACGTCCTGTCGGAAGAACAGTGCCGG
GAGCTCCACAGCGTGGCCAGTGGAATCATGCTTGTTGGTGATGGATACAGAGGAAAAACTTCACCCCATACACCCAATGAAAAGTTTGAA
GGTGCAACTGTCCTGAAAGCACTCAAATCTGGTTATGAAGGTCGAGTCCCACTGAAGAGCGCTCGTCTGTTTTATGACATCAGCGAAAAG
GCTCGAAGGATTGTAGAATCTTATTTTATGCTGAACTCAACTCTGTATTTTTCCTATACACACATGGTCTGCCGAACAGCCCTGTCTGGT
CAGCAGGATAGAAGAAATGACCTCAGTCATCCCATCCATGCTGACAACTGTTTGTTGGATCCAGAGGCCAACGAATGCTGGAAGGAGCCT
CCTGCTTACACATTTCGAGACTATAGTGCTCTCCTATATATGAATGATGACTTTGAAGGAGGAGAATTCATATTCACAGAGATGGATGCT
AAGACTGTGACTGCCTCTATAAAACCAAAATGTGGGCGCATGATCAGCTTCTCATCTGGAGGAGAGAACCCTCATGGGGTGAAGGCAGTC
ACCAAGGGAAAGAGGTGTGCTGTGGCTCTGTGGTTCACCTTGGACCCACTTTATAGAGAATTGGAGCGAATACAGGCTGATGAAGTGATT
GCAATTCTGGATCAAGAACAGCAAGGGAAGCATGAACTGAATATCAACCCTAAAGATGAGCTATAAAAATGAGAAAGAATGTTCTATCAA
ATATTTATTTAAATTGTTAATCTTATGAGAACCTTTTTATTTTTGTACAGAGCCATGGTATAAATTAACAGGTTAATGTCAGTCATCAGA
TCTTCCTTCTCTTCCTAAGGATGCTTGTGTTGCCTCAATCTATCAATCTATCTTTCTTGTTTTGGGTTGTTTTCTCTCTCTCTCTCTCTC
TCTCTCTTCTTAGAGACATGGTCTAACCATGTTGTCTAGGATATAGGGCAGTGGCTATTCACAGATGTGATGATAGCACACTGGAGCCTC
AAACTCTTAGGCTCAGGCGATCCTTCAAGCCTCCCGGGGAGCTGGGACCACAGGCACGTGCCACCACACCCAGCTCTCTTTCTTGGTTTT
TCATCATTTCATGTATCTATCAAAGCCCAGTTCACCTCCTCCCCCAAACACACACACACACACACACACACACACACACACACACAATTA
AGTTGCTGCAAATTCAAAAGCTTAGAGAGAATAAGCTTCTTGGTGGTGAAACTACAACTCTCACGTGTGCTCCAGTTCTAAAATTAACCT
GTGCCTGGTCTCTGAAGCCCTTTCTTGCTCTGTGCCTTTCAGCCACATCCTTAGGTGCTAACGGCCATGAGCTCCGACTCTCCAAAGTGA
GCTCCACTTTGGGTCTGAGGAGCCCCTGGCAGAGTCCACGCTGCCTCAGGTATCATGGGCGTAATGATCACCCAGGCTCCGGGAGATCTC
ATGGATGATTACTGTATGAGACAGAGGGGACTTCAGTCTTTCCAGGGCCTTGGTGGAATTTTTGGCTCTGGTGTTTTCGCCAGACAATAA
ACTTACACTGGAAGCTTTGATTCACCCTCCACAGTACTCCAGAAAGGACTGTCCTATAAGTTGTACACTTTAAAAGGTCATGTAGAGGTT
GTAGTAGAATGGCTTTTCACCCTGGTGACTTTGGAAGAAACTCTTGAATACTGCCTGCATCCGGGCACCATGGCCAGGTTGCCTAGGAGT
GGGGTCCACTGATGAAAAGAGGTGTTTTGTACTTACATAAGAAAAATAAATTTCTGATTGATTTTAACCGTCATCTGCTTATATTTTGGG

>In-frame_ENST00000392460_ENST00000319332_TCGA-CN-A49A_TP63_chr3_189526315_+_LEPREL1_chr3_189713231_length(amino acids)=741AA_start in transcript=0_stop in transcript=2225
MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATNKIE
ISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVS
FQQSSTAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQAL
REYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALE
CAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSGVNV
EGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFE
GATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEP
PAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQADEVI

--------------------------------------------------------------
>In-frame_ENST00000440651_ENST00000319332_TCGA-CN-A49A_TP63_chr3_189526315_+_LEPREL1_chr3_189713231_length(transcript)=3410nt_BP=579nt
ATGAATTTTGAAACTTCACGGTGTGCCACCCTACAGTACTGCCCTGACCCTTACATCCAGCGTTTCGTAGAAACCCCAGCTCATTTCTCT
TGGAAAGAAAGTTATTACCGATCCACCATGTCCCAGAGCACACAGACAAATGAATTCCTCAGTCCAGAGGTTTTCCAGCATATCTGGGAT
TTTCTGGAACAGCCTATATGTTCAGTTCAGCCCATTGACTTGAACTTTGTGGATGAACCATCAGAAGATGGTGCGACAAACAAGATTGAG
ATTAGCATGGACTGTATCCGCATGCAGGACTCGGACCTGAGTGACCCCATGTGGCCACAGTACACGAACCTGGGGCTCCTGAACAGCATG
GACCAGCAGATTCAGAACGGCTCCTCGTCCACCAGTCCCTATAACACAGACCACGCGCAGAACAGCGTCACGGCGCCCTCGCCCTACGCA
CAGCCCAGCTCCACCTTCGATGCTCTCTCTCCATCACCCGCCATCCCCTCCAACACCGACTACCCAGGCCCGCACAGTTTCGACGTGTCC
TTCCAGCAGTCGAGCACCGCCAAGTCGGCCACCTGGACGCTTAACCAGCTCGAAAAAGCAGTGGAAGCAGCTCACACATTTTTCGTGGCT
AACCCTGAGCACATGGAAATGCAGCAGAACATTGAGAATTACAGGGCGACAGCTGGTGTTGAAGCATTGCAGTTGGTAGACAGAGAAGCC
AAGCCACACATGGAGAGTTACAATGCAGGAGTTAAACATTATGAGGCTGATGACTTTGAGATGGCTATCAGGCACTTCGAACAAGCCTTA
AGAGAATATTTCGTTGAAGATACAGAATGCCGGACCCTATGTGAGGGGCCTCAGAGATTTGAAGAATATGAGTATTTAGGGTATAAGGCT
GGTCTGTATGAAGCTATTGCAGATCACTACATGCAGGTGCTTGTTTGTCAGCATGAATGTGTGAGGGAACTTGCCACCCGCCCTGGCCGC
CTCTCTCCCATCGAGAATTTTCTTCCTCTGCACTATGATTACCTACAGTTTGCCTACTATCGAGTTGGTGAGTATGTGAAAGCCCTGGAG
TGTGCCAAAGCCTATCTTCTATGCCATCCAGATGATGAGGATGTCCTAGACAATGTGGATTACTATGAGAGTCTGCTGGATGATAGCATT
GACCCGGCATCCATTGAGGCCAGAGAGGATTTAACAATGTTTGTGAAACGTCATAAGCTGGAGTCTGAGCTGATAAAATCAGCTGCAGAA
GGTCTGGGGTTTTCATACACTGAACCGAATTATTGGATCAGATATGGAGGACGACAGGATGAGAATCGGGTCCCTTCAGGAGTGAACGTA
GAGGGAGCAGAAGTTCATGGATTCTCAATGGGAAAAAAGCTATCACCCAAGATAGATCGAGACCTAAGAGAAGGTGGTCCTCTACTCTAT
GAGAACATCACATTCGTCTACAACTCGGAGCAGCTGAACGGGACTCAGCGGGTTCTCCTGGATAACGTCCTGTCGGAAGAACAGTGCCGG
GAGCTCCACAGCGTGGCCAGTGGAATCATGCTTGTTGGTGATGGATACAGAGGAAAAACTTCACCCCATACACCCAATGAAAAGTTTGAA
GGTGCAACTGTCCTGAAAGCACTCAAATCTGGTTATGAAGGTCGAGTCCCACTGAAGAGCGCTCGTCTGTTTTATGACATCAGCGAAAAG
GCTCGAAGGATTGTAGAATCTTATTTTATGCTGAACTCAACTCTGTATTTTTCCTATACACACATGGTCTGCCGAACAGCCCTGTCTGGT
CAGCAGGATAGAAGAAATGACCTCAGTCATCCCATCCATGCTGACAACTGTTTGTTGGATCCAGAGGCCAACGAATGCTGGAAGGAGCCT
CCTGCTTACACATTTCGAGACTATAGTGCTCTCCTATATATGAATGATGACTTTGAAGGAGGAGAATTCATATTCACAGAGATGGATGCT
AAGACTGTGACTGCCTCTATAAAACCAAAATGTGGGCGCATGATCAGCTTCTCATCTGGAGGAGAGAACCCTCATGGGGTGAAGGCAGTC
ACCAAGGGAAAGAGGTGTGCTGTGGCTCTGTGGTTCACCTTGGACCCACTTTATAGAGAATTGGAGCGAATACAGGCTGATGAAGTGATT
GCAATTCTGGATCAAGAACAGCAAGGGAAGCATGAACTGAATATCAACCCTAAAGATGAGCTATAAAAATGAGAAAGAATGTTCTATCAA
ATATTTATTTAAATTGTTAATCTTATGAGAACCTTTTTATTTTTGTACAGAGCCATGGTATAAATTAACAGGTTAATGTCAGTCATCAGA
TCTTCCTTCTCTTCCTAAGGATGCTTGTGTTGCCTCAATCTATCAATCTATCTTTCTTGTTTTGGGTTGTTTTCTCTCTCTCTCTCTCTC
TCTCTCTTCTTAGAGACATGGTCTAACCATGTTGTCTAGGATATAGGGCAGTGGCTATTCACAGATGTGATGATAGCACACTGGAGCCTC
AAACTCTTAGGCTCAGGCGATCCTTCAAGCCTCCCGGGGAGCTGGGACCACAGGCACGTGCCACCACACCCAGCTCTCTTTCTTGGTTTT
TCATCATTTCATGTATCTATCAAAGCCCAGTTCACCTCCTCCCCCAAACACACACACACACACACACACACACACACACACACACAATTA
AGTTGCTGCAAATTCAAAAGCTTAGAGAGAATAAGCTTCTTGGTGGTGAAACTACAACTCTCACGTGTGCTCCAGTTCTAAAATTAACCT
GTGCCTGGTCTCTGAAGCCCTTTCTTGCTCTGTGCCTTTCAGCCACATCCTTAGGTGCTAACGGCCATGAGCTCCGACTCTCCAAAGTGA
GCTCCACTTTGGGTCTGAGGAGCCCCTGGCAGAGTCCACGCTGCCTCAGGTATCATGGGCGTAATGATCACCCAGGCTCCGGGAGATCTC
ATGGATGATTACTGTATGAGACAGAGGGGACTTCAGTCTTTCCAGGGCCTTGGTGGAATTTTTGGCTCTGGTGTTTTCGCCAGACAATAA
ACTTACACTGGAAGCTTTGATTCACCCTCCACAGTACTCCAGAAAGGACTGTCCTATAAGTTGTACACTTTAAAAGGTCATGTAGAGGTT
GTAGTAGAATGGCTTTTCACCCTGGTGACTTTGGAAGAAACTCTTGAATACTGCCTGCATCCGGGCACCATGGCCAGGTTGCCTAGGAGT
GGGGTCCACTGATGAAAAGAGGTGTTTTGTACTTACATAAGAAAAATAAATTTCTGATTGATTTTAACCGTCATCTGCTTATATTTTGGG

>In-frame_ENST00000440651_ENST00000319332_TCGA-CN-A49A_TP63_chr3_189526315_+_LEPREL1_chr3_189713231_length(amino acids)=741AA_start in transcript=0_stop in transcript=2225
MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATNKIE
ISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVS
FQQSSTAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQAL
REYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALE
CAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSGVNV
EGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFE
GATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEP
PAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQADEVI

--------------------------------------------------------------
>In-frame_ENST00000354600_ENST00000319332_TCGA-CN-A49A_TP63_chr3_189526315_+_LEPREL1_chr3_189713231_length(transcript)=3269nt_BP=438nt
AGAGAGAGAAAGAGAGAGAGGGACTTGAGTTCTGTTATCTTCTTAAGTAGATTCATATTGTAAGGGTCTCGGGGTGGGGGGGTTGGCAAA
ATCCTGGAGCCAGAAGAAAGGACAGCAGCATTGATCAATCTTACAGCTAACATGTTGTACCTGGAAAACAATGCCCAGACTCAATTTAGT
GAGCCACAGTACACGAACCTGGGGCTCCTGAACAGCATGGACCAGCAGATTCAGAACGGCTCCTCGTCCACCAGTCCCTATAACACAGAC
CACGCGCAGAACAGCGTCACGGCGCCCTCGCCCTACGCACAGCCCAGCTCCACCTTCGATGCTCTCTCTCCATCACCCGCCATCCCCTCC
AACACCGACTACCCAGGCCCGCACAGTTTCGACGTGTCCTTCCAGCAGTCGAGCACCGCCAAGTCGGCCACCTGGACGCTTAACCAGCTC
GAAAAAGCAGTGGAAGCAGCTCACACATTTTTCGTGGCTAACCCTGAGCACATGGAAATGCAGCAGAACATTGAGAATTACAGGGCGACA
GCTGGTGTTGAAGCATTGCAGTTGGTAGACAGAGAAGCCAAGCCACACATGGAGAGTTACAATGCAGGAGTTAAACATTATGAGGCTGAT
GACTTTGAGATGGCTATCAGGCACTTCGAACAAGCCTTAAGAGAATATTTCGTTGAAGATACAGAATGCCGGACCCTATGTGAGGGGCCT
CAGAGATTTGAAGAATATGAGTATTTAGGGTATAAGGCTGGTCTGTATGAAGCTATTGCAGATCACTACATGCAGGTGCTTGTTTGTCAG
CATGAATGTGTGAGGGAACTTGCCACCCGCCCTGGCCGCCTCTCTCCCATCGAGAATTTTCTTCCTCTGCACTATGATTACCTACAGTTT
GCCTACTATCGAGTTGGTGAGTATGTGAAAGCCCTGGAGTGTGCCAAAGCCTATCTTCTATGCCATCCAGATGATGAGGATGTCCTAGAC
AATGTGGATTACTATGAGAGTCTGCTGGATGATAGCATTGACCCGGCATCCATTGAGGCCAGAGAGGATTTAACAATGTTTGTGAAACGT
CATAAGCTGGAGTCTGAGCTGATAAAATCAGCTGCAGAAGGTCTGGGGTTTTCATACACTGAACCGAATTATTGGATCAGATATGGAGGA
CGACAGGATGAGAATCGGGTCCCTTCAGGAGTGAACGTAGAGGGAGCAGAAGTTCATGGATTCTCAATGGGAAAAAAGCTATCACCCAAG
ATAGATCGAGACCTAAGAGAAGGTGGTCCTCTACTCTATGAGAACATCACATTCGTCTACAACTCGGAGCAGCTGAACGGGACTCAGCGG
GTTCTCCTGGATAACGTCCTGTCGGAAGAACAGTGCCGGGAGCTCCACAGCGTGGCCAGTGGAATCATGCTTGTTGGTGATGGATACAGA
GGAAAAACTTCACCCCATACACCCAATGAAAAGTTTGAAGGTGCAACTGTCCTGAAAGCACTCAAATCTGGTTATGAAGGTCGAGTCCCA
CTGAAGAGCGCTCGTCTGTTTTATGACATCAGCGAAAAGGCTCGAAGGATTGTAGAATCTTATTTTATGCTGAACTCAACTCTGTATTTT
TCCTATACACACATGGTCTGCCGAACAGCCCTGTCTGGTCAGCAGGATAGAAGAAATGACCTCAGTCATCCCATCCATGCTGACAACTGT
TTGTTGGATCCAGAGGCCAACGAATGCTGGAAGGAGCCTCCTGCTTACACATTTCGAGACTATAGTGCTCTCCTATATATGAATGATGAC
TTTGAAGGAGGAGAATTCATATTCACAGAGATGGATGCTAAGACTGTGACTGCCTCTATAAAACCAAAATGTGGGCGCATGATCAGCTTC
TCATCTGGAGGAGAGAACCCTCATGGGGTGAAGGCAGTCACCAAGGGAAAGAGGTGTGCTGTGGCTCTGTGGTTCACCTTGGACCCACTT
TATAGAGAATTGGAGCGAATACAGGCTGATGAAGTGATTGCAATTCTGGATCAAGAACAGCAAGGGAAGCATGAACTGAATATCAACCCT
AAAGATGAGCTATAAAAATGAGAAAGAATGTTCTATCAAATATTTATTTAAATTGTTAATCTTATGAGAACCTTTTTATTTTTGTACAGA
GCCATGGTATAAATTAACAGGTTAATGTCAGTCATCAGATCTTCCTTCTCTTCCTAAGGATGCTTGTGTTGCCTCAATCTATCAATCTAT
CTTTCTTGTTTTGGGTTGTTTTCTCTCTCTCTCTCTCTCTCTCTCTTCTTAGAGACATGGTCTAACCATGTTGTCTAGGATATAGGGCAG
TGGCTATTCACAGATGTGATGATAGCACACTGGAGCCTCAAACTCTTAGGCTCAGGCGATCCTTCAAGCCTCCCGGGGAGCTGGGACCAC
AGGCACGTGCCACCACACCCAGCTCTCTTTCTTGGTTTTTCATCATTTCATGTATCTATCAAAGCCCAGTTCACCTCCTCCCCCAAACAC
ACACACACACACACACACACACACACACACACACAATTAAGTTGCTGCAAATTCAAAAGCTTAGAGAGAATAAGCTTCTTGGTGGTGAAA
CTACAACTCTCACGTGTGCTCCAGTTCTAAAATTAACCTGTGCCTGGTCTCTGAAGCCCTTTCTTGCTCTGTGCCTTTCAGCCACATCCT
TAGGTGCTAACGGCCATGAGCTCCGACTCTCCAAAGTGAGCTCCACTTTGGGTCTGAGGAGCCCCTGGCAGAGTCCACGCTGCCTCAGGT
ATCATGGGCGTAATGATCACCCAGGCTCCGGGAGATCTCATGGATGATTACTGTATGAGACAGAGGGGACTTCAGTCTTTCCAGGGCCTT
GGTGGAATTTTTGGCTCTGGTGTTTTCGCCAGACAATAAACTTACACTGGAAGCTTTGATTCACCCTCCACAGTACTCCAGAAAGGACTG
TCCTATAAGTTGTACACTTTAAAAGGTCATGTAGAGGTTGTAGTAGAATGGCTTTTCACCCTGGTGACTTTGGAAGAAACTCTTGAATAC
TGCCTGCATCCGGGCACCATGGCCAGGTTGCCTAGGAGTGGGGTCCACTGATGAAAAGAGGTGTTTTGTACTTACATAAGAAAAATAAAT
TTCTGATTGATTTTAACCGTCATCTGCTTATATTTTGGGGGCCCCTCCTCATTGCTGCTATCCAGCACACAGATTTGTGCTTGTGTCTGA

>In-frame_ENST00000354600_ENST00000319332_TCGA-CN-A49A_TP63_chr3_189526315_+_LEPREL1_chr3_189713231_length(amino acids)=663AA_start in transcript=93_stop in transcript=2084
MEPEERTAALINLTANMLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSN
TDYPGPHSFDVSFQQSSTAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADD
FEMAIRHFEQALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFA
YYRVGEYVKALECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGR
QDENRVPSGVNVEGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRG
KTSPHTPNEKFEGATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCL
LDPEANECWKEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLY

--------------------------------------------------------------
>In-frame_ENST00000437221_ENST00000319332_TCGA-CN-A49A_TP63_chr3_189526315_+_LEPREL1_chr3_189713231_length(transcript)=3128nt_BP=297nt
ATGTTGTACCTGGAAAACAATGCCCAGACTCAATTTAGTGAGCCACAGTACACGAACCTGGGGCTCCTGAACAGCATGGACCAGCAGATT
CAGAACGGCTCCTCGTCCACCAGTCCCTATAACACAGACCACGCGCAGAACAGCGTCACGGCGCCCTCGCCCTACGCACAGCCCAGCTCC
ACCTTCGATGCTCTCTCTCCATCACCCGCCATCCCCTCCAACACCGACTACCCAGGCCCGCACAGTTTCGACGTGTCCTTCCAGCAGTCG
AGCACCGCCAAGTCGGCCACCTGGACGCTTAACCAGCTCGAAAAAGCAGTGGAAGCAGCTCACACATTTTTCGTGGCTAACCCTGAGCAC
ATGGAAATGCAGCAGAACATTGAGAATTACAGGGCGACAGCTGGTGTTGAAGCATTGCAGTTGGTAGACAGAGAAGCCAAGCCACACATG
GAGAGTTACAATGCAGGAGTTAAACATTATGAGGCTGATGACTTTGAGATGGCTATCAGGCACTTCGAACAAGCCTTAAGAGAATATTTC
GTTGAAGATACAGAATGCCGGACCCTATGTGAGGGGCCTCAGAGATTTGAAGAATATGAGTATTTAGGGTATAAGGCTGGTCTGTATGAA
GCTATTGCAGATCACTACATGCAGGTGCTTGTTTGTCAGCATGAATGTGTGAGGGAACTTGCCACCCGCCCTGGCCGCCTCTCTCCCATC
GAGAATTTTCTTCCTCTGCACTATGATTACCTACAGTTTGCCTACTATCGAGTTGGTGAGTATGTGAAAGCCCTGGAGTGTGCCAAAGCC
TATCTTCTATGCCATCCAGATGATGAGGATGTCCTAGACAATGTGGATTACTATGAGAGTCTGCTGGATGATAGCATTGACCCGGCATCC
ATTGAGGCCAGAGAGGATTTAACAATGTTTGTGAAACGTCATAAGCTGGAGTCTGAGCTGATAAAATCAGCTGCAGAAGGTCTGGGGTTT
TCATACACTGAACCGAATTATTGGATCAGATATGGAGGACGACAGGATGAGAATCGGGTCCCTTCAGGAGTGAACGTAGAGGGAGCAGAA
GTTCATGGATTCTCAATGGGAAAAAAGCTATCACCCAAGATAGATCGAGACCTAAGAGAAGGTGGTCCTCTACTCTATGAGAACATCACA
TTCGTCTACAACTCGGAGCAGCTGAACGGGACTCAGCGGGTTCTCCTGGATAACGTCCTGTCGGAAGAACAGTGCCGGGAGCTCCACAGC
GTGGCCAGTGGAATCATGCTTGTTGGTGATGGATACAGAGGAAAAACTTCACCCCATACACCCAATGAAAAGTTTGAAGGTGCAACTGTC
CTGAAAGCACTCAAATCTGGTTATGAAGGTCGAGTCCCACTGAAGAGCGCTCGTCTGTTTTATGACATCAGCGAAAAGGCTCGAAGGATT
GTAGAATCTTATTTTATGCTGAACTCAACTCTGTATTTTTCCTATACACACATGGTCTGCCGAACAGCCCTGTCTGGTCAGCAGGATAGA
AGAAATGACCTCAGTCATCCCATCCATGCTGACAACTGTTTGTTGGATCCAGAGGCCAACGAATGCTGGAAGGAGCCTCCTGCTTACACA
TTTCGAGACTATAGTGCTCTCCTATATATGAATGATGACTTTGAAGGAGGAGAATTCATATTCACAGAGATGGATGCTAAGACTGTGACT
GCCTCTATAAAACCAAAATGTGGGCGCATGATCAGCTTCTCATCTGGAGGAGAGAACCCTCATGGGGTGAAGGCAGTCACCAAGGGAAAG
AGGTGTGCTGTGGCTCTGTGGTTCACCTTGGACCCACTTTATAGAGAATTGGAGCGAATACAGGCTGATGAAGTGATTGCAATTCTGGAT
CAAGAACAGCAAGGGAAGCATGAACTGAATATCAACCCTAAAGATGAGCTATAAAAATGAGAAAGAATGTTCTATCAAATATTTATTTAA
ATTGTTAATCTTATGAGAACCTTTTTATTTTTGTACAGAGCCATGGTATAAATTAACAGGTTAATGTCAGTCATCAGATCTTCCTTCTCT
TCCTAAGGATGCTTGTGTTGCCTCAATCTATCAATCTATCTTTCTTGTTTTGGGTTGTTTTCTCTCTCTCTCTCTCTCTCTCTCTTCTTA
GAGACATGGTCTAACCATGTTGTCTAGGATATAGGGCAGTGGCTATTCACAGATGTGATGATAGCACACTGGAGCCTCAAACTCTTAGGC
TCAGGCGATCCTTCAAGCCTCCCGGGGAGCTGGGACCACAGGCACGTGCCACCACACCCAGCTCTCTTTCTTGGTTTTTCATCATTTCAT
GTATCTATCAAAGCCCAGTTCACCTCCTCCCCCAAACACACACACACACACACACACACACACACACACACACAATTAAGTTGCTGCAAA
TTCAAAAGCTTAGAGAGAATAAGCTTCTTGGTGGTGAAACTACAACTCTCACGTGTGCTCCAGTTCTAAAATTAACCTGTGCCTGGTCTC
TGAAGCCCTTTCTTGCTCTGTGCCTTTCAGCCACATCCTTAGGTGCTAACGGCCATGAGCTCCGACTCTCCAAAGTGAGCTCCACTTTGG
GTCTGAGGAGCCCCTGGCAGAGTCCACGCTGCCTCAGGTATCATGGGCGTAATGATCACCCAGGCTCCGGGAGATCTCATGGATGATTAC
TGTATGAGACAGAGGGGACTTCAGTCTTTCCAGGGCCTTGGTGGAATTTTTGGCTCTGGTGTTTTCGCCAGACAATAAACTTACACTGGA
AGCTTTGATTCACCCTCCACAGTACTCCAGAAAGGACTGTCCTATAAGTTGTACACTTTAAAAGGTCATGTAGAGGTTGTAGTAGAATGG
CTTTTCACCCTGGTGACTTTGGAAGAAACTCTTGAATACTGCCTGCATCCGGGCACCATGGCCAGGTTGCCTAGGAGTGGGGTCCACTGA
TGAAAAGAGGTGTTTTGTACTTACATAAGAAAAATAAATTTCTGATTGATTTTAACCGTCATCTGCTTATATTTTGGGGGCCCCTCCTCA

>In-frame_ENST00000437221_ENST00000319332_TCGA-CN-A49A_TP63_chr3_189526315_+_LEPREL1_chr3_189713231_length(amino acids)=647AA_start in transcript=0_stop in transcript=1943
MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQS
STAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQALREYF
VEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKA
YLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSGVNVEGAE
VHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFEGATV
LKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYT
FRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQADEVIAILD

--------------------------------------------------------------
>In-frame_ENST00000392463_ENST00000319332_TCGA-CN-A49A_TP63_chr3_189526315_+_LEPREL1_chr3_189713231_length(transcript)=3128nt_BP=297nt
ATGTTGTACCTGGAAAACAATGCCCAGACTCAATTTAGTGAGCCACAGTACACGAACCTGGGGCTCCTGAACAGCATGGACCAGCAGATT
CAGAACGGCTCCTCGTCCACCAGTCCCTATAACACAGACCACGCGCAGAACAGCGTCACGGCGCCCTCGCCCTACGCACAGCCCAGCTCC
ACCTTCGATGCTCTCTCTCCATCACCCGCCATCCCCTCCAACACCGACTACCCAGGCCCGCACAGTTTCGACGTGTCCTTCCAGCAGTCG
AGCACCGCCAAGTCGGCCACCTGGACGCTTAACCAGCTCGAAAAAGCAGTGGAAGCAGCTCACACATTTTTCGTGGCTAACCCTGAGCAC
ATGGAAATGCAGCAGAACATTGAGAATTACAGGGCGACAGCTGGTGTTGAAGCATTGCAGTTGGTAGACAGAGAAGCCAAGCCACACATG
GAGAGTTACAATGCAGGAGTTAAACATTATGAGGCTGATGACTTTGAGATGGCTATCAGGCACTTCGAACAAGCCTTAAGAGAATATTTC
GTTGAAGATACAGAATGCCGGACCCTATGTGAGGGGCCTCAGAGATTTGAAGAATATGAGTATTTAGGGTATAAGGCTGGTCTGTATGAA
GCTATTGCAGATCACTACATGCAGGTGCTTGTTTGTCAGCATGAATGTGTGAGGGAACTTGCCACCCGCCCTGGCCGCCTCTCTCCCATC
GAGAATTTTCTTCCTCTGCACTATGATTACCTACAGTTTGCCTACTATCGAGTTGGTGAGTATGTGAAAGCCCTGGAGTGTGCCAAAGCC
TATCTTCTATGCCATCCAGATGATGAGGATGTCCTAGACAATGTGGATTACTATGAGAGTCTGCTGGATGATAGCATTGACCCGGCATCC
ATTGAGGCCAGAGAGGATTTAACAATGTTTGTGAAACGTCATAAGCTGGAGTCTGAGCTGATAAAATCAGCTGCAGAAGGTCTGGGGTTT
TCATACACTGAACCGAATTATTGGATCAGATATGGAGGACGACAGGATGAGAATCGGGTCCCTTCAGGAGTGAACGTAGAGGGAGCAGAA
GTTCATGGATTCTCAATGGGAAAAAAGCTATCACCCAAGATAGATCGAGACCTAAGAGAAGGTGGTCCTCTACTCTATGAGAACATCACA
TTCGTCTACAACTCGGAGCAGCTGAACGGGACTCAGCGGGTTCTCCTGGATAACGTCCTGTCGGAAGAACAGTGCCGGGAGCTCCACAGC
GTGGCCAGTGGAATCATGCTTGTTGGTGATGGATACAGAGGAAAAACTTCACCCCATACACCCAATGAAAAGTTTGAAGGTGCAACTGTC
CTGAAAGCACTCAAATCTGGTTATGAAGGTCGAGTCCCACTGAAGAGCGCTCGTCTGTTTTATGACATCAGCGAAAAGGCTCGAAGGATT
GTAGAATCTTATTTTATGCTGAACTCAACTCTGTATTTTTCCTATACACACATGGTCTGCCGAACAGCCCTGTCTGGTCAGCAGGATAGA
AGAAATGACCTCAGTCATCCCATCCATGCTGACAACTGTTTGTTGGATCCAGAGGCCAACGAATGCTGGAAGGAGCCTCCTGCTTACACA
TTTCGAGACTATAGTGCTCTCCTATATATGAATGATGACTTTGAAGGAGGAGAATTCATATTCACAGAGATGGATGCTAAGACTGTGACT
GCCTCTATAAAACCAAAATGTGGGCGCATGATCAGCTTCTCATCTGGAGGAGAGAACCCTCATGGGGTGAAGGCAGTCACCAAGGGAAAG
AGGTGTGCTGTGGCTCTGTGGTTCACCTTGGACCCACTTTATAGAGAATTGGAGCGAATACAGGCTGATGAAGTGATTGCAATTCTGGAT
CAAGAACAGCAAGGGAAGCATGAACTGAATATCAACCCTAAAGATGAGCTATAAAAATGAGAAAGAATGTTCTATCAAATATTTATTTAA
ATTGTTAATCTTATGAGAACCTTTTTATTTTTGTACAGAGCCATGGTATAAATTAACAGGTTAATGTCAGTCATCAGATCTTCCTTCTCT
TCCTAAGGATGCTTGTGTTGCCTCAATCTATCAATCTATCTTTCTTGTTTTGGGTTGTTTTCTCTCTCTCTCTCTCTCTCTCTCTTCTTA
GAGACATGGTCTAACCATGTTGTCTAGGATATAGGGCAGTGGCTATTCACAGATGTGATGATAGCACACTGGAGCCTCAAACTCTTAGGC
TCAGGCGATCCTTCAAGCCTCCCGGGGAGCTGGGACCACAGGCACGTGCCACCACACCCAGCTCTCTTTCTTGGTTTTTCATCATTTCAT
GTATCTATCAAAGCCCAGTTCACCTCCTCCCCCAAACACACACACACACACACACACACACACACACACACACAATTAAGTTGCTGCAAA
TTCAAAAGCTTAGAGAGAATAAGCTTCTTGGTGGTGAAACTACAACTCTCACGTGTGCTCCAGTTCTAAAATTAACCTGTGCCTGGTCTC
TGAAGCCCTTTCTTGCTCTGTGCCTTTCAGCCACATCCTTAGGTGCTAACGGCCATGAGCTCCGACTCTCCAAAGTGAGCTCCACTTTGG
GTCTGAGGAGCCCCTGGCAGAGTCCACGCTGCCTCAGGTATCATGGGCGTAATGATCACCCAGGCTCCGGGAGATCTCATGGATGATTAC
TGTATGAGACAGAGGGGACTTCAGTCTTTCCAGGGCCTTGGTGGAATTTTTGGCTCTGGTGTTTTCGCCAGACAATAAACTTACACTGGA
AGCTTTGATTCACCCTCCACAGTACTCCAGAAAGGACTGTCCTATAAGTTGTACACTTTAAAAGGTCATGTAGAGGTTGTAGTAGAATGG
CTTTTCACCCTGGTGACTTTGGAAGAAACTCTTGAATACTGCCTGCATCCGGGCACCATGGCCAGGTTGCCTAGGAGTGGGGTCCACTGA
TGAAAAGAGGTGTTTTGTACTTACATAAGAAAAATAAATTTCTGATTGATTTTAACCGTCATCTGCTTATATTTTGGGGGCCCCTCCTCA

>In-frame_ENST00000392463_ENST00000319332_TCGA-CN-A49A_TP63_chr3_189526315_+_LEPREL1_chr3_189713231_length(amino acids)=647AA_start in transcript=0_stop in transcript=1943
MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQS
STAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQALREYF
VEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKA
YLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSGVNVEGAE
VHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFEGATV
LKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYT
FRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQADEVIAILD

--------------------------------------------------------------
>In-frame_ENST00000392461_ENST00000319332_TCGA-CN-A49A_TP63_chr3_189526315_+_LEPREL1_chr3_189713231_length(transcript)=3128nt_BP=297nt
ATGTTGTACCTGGAAAACAATGCCCAGACTCAATTTAGTGAGCCACAGTACACGAACCTGGGGCTCCTGAACAGCATGGACCAGCAGATT
CAGAACGGCTCCTCGTCCACCAGTCCCTATAACACAGACCACGCGCAGAACAGCGTCACGGCGCCCTCGCCCTACGCACAGCCCAGCTCC
ACCTTCGATGCTCTCTCTCCATCACCCGCCATCCCCTCCAACACCGACTACCCAGGCCCGCACAGTTTCGACGTGTCCTTCCAGCAGTCG
AGCACCGCCAAGTCGGCCACCTGGACGCTTAACCAGCTCGAAAAAGCAGTGGAAGCAGCTCACACATTTTTCGTGGCTAACCCTGAGCAC
ATGGAAATGCAGCAGAACATTGAGAATTACAGGGCGACAGCTGGTGTTGAAGCATTGCAGTTGGTAGACAGAGAAGCCAAGCCACACATG
GAGAGTTACAATGCAGGAGTTAAACATTATGAGGCTGATGACTTTGAGATGGCTATCAGGCACTTCGAACAAGCCTTAAGAGAATATTTC
GTTGAAGATACAGAATGCCGGACCCTATGTGAGGGGCCTCAGAGATTTGAAGAATATGAGTATTTAGGGTATAAGGCTGGTCTGTATGAA
GCTATTGCAGATCACTACATGCAGGTGCTTGTTTGTCAGCATGAATGTGTGAGGGAACTTGCCACCCGCCCTGGCCGCCTCTCTCCCATC
GAGAATTTTCTTCCTCTGCACTATGATTACCTACAGTTTGCCTACTATCGAGTTGGTGAGTATGTGAAAGCCCTGGAGTGTGCCAAAGCC
TATCTTCTATGCCATCCAGATGATGAGGATGTCCTAGACAATGTGGATTACTATGAGAGTCTGCTGGATGATAGCATTGACCCGGCATCC
ATTGAGGCCAGAGAGGATTTAACAATGTTTGTGAAACGTCATAAGCTGGAGTCTGAGCTGATAAAATCAGCTGCAGAAGGTCTGGGGTTT
TCATACACTGAACCGAATTATTGGATCAGATATGGAGGACGACAGGATGAGAATCGGGTCCCTTCAGGAGTGAACGTAGAGGGAGCAGAA
GTTCATGGATTCTCAATGGGAAAAAAGCTATCACCCAAGATAGATCGAGACCTAAGAGAAGGTGGTCCTCTACTCTATGAGAACATCACA
TTCGTCTACAACTCGGAGCAGCTGAACGGGACTCAGCGGGTTCTCCTGGATAACGTCCTGTCGGAAGAACAGTGCCGGGAGCTCCACAGC
GTGGCCAGTGGAATCATGCTTGTTGGTGATGGATACAGAGGAAAAACTTCACCCCATACACCCAATGAAAAGTTTGAAGGTGCAACTGTC
CTGAAAGCACTCAAATCTGGTTATGAAGGTCGAGTCCCACTGAAGAGCGCTCGTCTGTTTTATGACATCAGCGAAAAGGCTCGAAGGATT
GTAGAATCTTATTTTATGCTGAACTCAACTCTGTATTTTTCCTATACACACATGGTCTGCCGAACAGCCCTGTCTGGTCAGCAGGATAGA
AGAAATGACCTCAGTCATCCCATCCATGCTGACAACTGTTTGTTGGATCCAGAGGCCAACGAATGCTGGAAGGAGCCTCCTGCTTACACA
TTTCGAGACTATAGTGCTCTCCTATATATGAATGATGACTTTGAAGGAGGAGAATTCATATTCACAGAGATGGATGCTAAGACTGTGACT
GCCTCTATAAAACCAAAATGTGGGCGCATGATCAGCTTCTCATCTGGAGGAGAGAACCCTCATGGGGTGAAGGCAGTCACCAAGGGAAAG
AGGTGTGCTGTGGCTCTGTGGTTCACCTTGGACCCACTTTATAGAGAATTGGAGCGAATACAGGCTGATGAAGTGATTGCAATTCTGGAT
CAAGAACAGCAAGGGAAGCATGAACTGAATATCAACCCTAAAGATGAGCTATAAAAATGAGAAAGAATGTTCTATCAAATATTTATTTAA
ATTGTTAATCTTATGAGAACCTTTTTATTTTTGTACAGAGCCATGGTATAAATTAACAGGTTAATGTCAGTCATCAGATCTTCCTTCTCT
TCCTAAGGATGCTTGTGTTGCCTCAATCTATCAATCTATCTTTCTTGTTTTGGGTTGTTTTCTCTCTCTCTCTCTCTCTCTCTCTTCTTA
GAGACATGGTCTAACCATGTTGTCTAGGATATAGGGCAGTGGCTATTCACAGATGTGATGATAGCACACTGGAGCCTCAAACTCTTAGGC
TCAGGCGATCCTTCAAGCCTCCCGGGGAGCTGGGACCACAGGCACGTGCCACCACACCCAGCTCTCTTTCTTGGTTTTTCATCATTTCAT
GTATCTATCAAAGCCCAGTTCACCTCCTCCCCCAAACACACACACACACACACACACACACACACACACACACAATTAAGTTGCTGCAAA
TTCAAAAGCTTAGAGAGAATAAGCTTCTTGGTGGTGAAACTACAACTCTCACGTGTGCTCCAGTTCTAAAATTAACCTGTGCCTGGTCTC
TGAAGCCCTTTCTTGCTCTGTGCCTTTCAGCCACATCCTTAGGTGCTAACGGCCATGAGCTCCGACTCTCCAAAGTGAGCTCCACTTTGG
GTCTGAGGAGCCCCTGGCAGAGTCCACGCTGCCTCAGGTATCATGGGCGTAATGATCACCCAGGCTCCGGGAGATCTCATGGATGATTAC
TGTATGAGACAGAGGGGACTTCAGTCTTTCCAGGGCCTTGGTGGAATTTTTGGCTCTGGTGTTTTCGCCAGACAATAAACTTACACTGGA
AGCTTTGATTCACCCTCCACAGTACTCCAGAAAGGACTGTCCTATAAGTTGTACACTTTAAAAGGTCATGTAGAGGTTGTAGTAGAATGG
CTTTTCACCCTGGTGACTTTGGAAGAAACTCTTGAATACTGCCTGCATCCGGGCACCATGGCCAGGTTGCCTAGGAGTGGGGTCCACTGA
TGAAAAGAGGTGTTTTGTACTTACATAAGAAAAATAAATTTCTGATTGATTTTAACCGTCATCTGCTTATATTTTGGGGGCCCCTCCTCA

>In-frame_ENST00000392461_ENST00000319332_TCGA-CN-A49A_TP63_chr3_189526315_+_LEPREL1_chr3_189713231_length(amino acids)=647AA_start in transcript=0_stop in transcript=1943
MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQS
STAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQALREYF
VEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKA
YLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSGVNVEGAE
VHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFEGATV
LKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYT
FRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQADEVIAILD

--------------------------------------------------------------
>In-frame_ENST00000456148_ENST00000319332_TCGA-CN-A49A_TP63_chr3_189526315_+_LEPREL1_chr3_189713231_length(transcript)=3128nt_BP=297nt
ATGTTGTACCTGGAAAACAATGCCCAGACTCAATTTAGTGAGCCACAGTACACGAACCTGGGGCTCCTGAACAGCATGGACCAGCAGATT
CAGAACGGCTCCTCGTCCACCAGTCCCTATAACACAGACCACGCGCAGAACAGCGTCACGGCGCCCTCGCCCTACGCACAGCCCAGCTCC
ACCTTCGATGCTCTCTCTCCATCACCCGCCATCCCCTCCAACACCGACTACCCAGGCCCGCACAGTTTCGACGTGTCCTTCCAGCAGTCG
AGCACCGCCAAGTCGGCCACCTGGACGCTTAACCAGCTCGAAAAAGCAGTGGAAGCAGCTCACACATTTTTCGTGGCTAACCCTGAGCAC
ATGGAAATGCAGCAGAACATTGAGAATTACAGGGCGACAGCTGGTGTTGAAGCATTGCAGTTGGTAGACAGAGAAGCCAAGCCACACATG
GAGAGTTACAATGCAGGAGTTAAACATTATGAGGCTGATGACTTTGAGATGGCTATCAGGCACTTCGAACAAGCCTTAAGAGAATATTTC
GTTGAAGATACAGAATGCCGGACCCTATGTGAGGGGCCTCAGAGATTTGAAGAATATGAGTATTTAGGGTATAAGGCTGGTCTGTATGAA
GCTATTGCAGATCACTACATGCAGGTGCTTGTTTGTCAGCATGAATGTGTGAGGGAACTTGCCACCCGCCCTGGCCGCCTCTCTCCCATC
GAGAATTTTCTTCCTCTGCACTATGATTACCTACAGTTTGCCTACTATCGAGTTGGTGAGTATGTGAAAGCCCTGGAGTGTGCCAAAGCC
TATCTTCTATGCCATCCAGATGATGAGGATGTCCTAGACAATGTGGATTACTATGAGAGTCTGCTGGATGATAGCATTGACCCGGCATCC
ATTGAGGCCAGAGAGGATTTAACAATGTTTGTGAAACGTCATAAGCTGGAGTCTGAGCTGATAAAATCAGCTGCAGAAGGTCTGGGGTTT
TCATACACTGAACCGAATTATTGGATCAGATATGGAGGACGACAGGATGAGAATCGGGTCCCTTCAGGAGTGAACGTAGAGGGAGCAGAA
GTTCATGGATTCTCAATGGGAAAAAAGCTATCACCCAAGATAGATCGAGACCTAAGAGAAGGTGGTCCTCTACTCTATGAGAACATCACA
TTCGTCTACAACTCGGAGCAGCTGAACGGGACTCAGCGGGTTCTCCTGGATAACGTCCTGTCGGAAGAACAGTGCCGGGAGCTCCACAGC
GTGGCCAGTGGAATCATGCTTGTTGGTGATGGATACAGAGGAAAAACTTCACCCCATACACCCAATGAAAAGTTTGAAGGTGCAACTGTC
CTGAAAGCACTCAAATCTGGTTATGAAGGTCGAGTCCCACTGAAGAGCGCTCGTCTGTTTTATGACATCAGCGAAAAGGCTCGAAGGATT
GTAGAATCTTATTTTATGCTGAACTCAACTCTGTATTTTTCCTATACACACATGGTCTGCCGAACAGCCCTGTCTGGTCAGCAGGATAGA
AGAAATGACCTCAGTCATCCCATCCATGCTGACAACTGTTTGTTGGATCCAGAGGCCAACGAATGCTGGAAGGAGCCTCCTGCTTACACA
TTTCGAGACTATAGTGCTCTCCTATATATGAATGATGACTTTGAAGGAGGAGAATTCATATTCACAGAGATGGATGCTAAGACTGTGACT
GCCTCTATAAAACCAAAATGTGGGCGCATGATCAGCTTCTCATCTGGAGGAGAGAACCCTCATGGGGTGAAGGCAGTCACCAAGGGAAAG
AGGTGTGCTGTGGCTCTGTGGTTCACCTTGGACCCACTTTATAGAGAATTGGAGCGAATACAGGCTGATGAAGTGATTGCAATTCTGGAT
CAAGAACAGCAAGGGAAGCATGAACTGAATATCAACCCTAAAGATGAGCTATAAAAATGAGAAAGAATGTTCTATCAAATATTTATTTAA
ATTGTTAATCTTATGAGAACCTTTTTATTTTTGTACAGAGCCATGGTATAAATTAACAGGTTAATGTCAGTCATCAGATCTTCCTTCTCT
TCCTAAGGATGCTTGTGTTGCCTCAATCTATCAATCTATCTTTCTTGTTTTGGGTTGTTTTCTCTCTCTCTCTCTCTCTCTCTCTTCTTA
GAGACATGGTCTAACCATGTTGTCTAGGATATAGGGCAGTGGCTATTCACAGATGTGATGATAGCACACTGGAGCCTCAAACTCTTAGGC
TCAGGCGATCCTTCAAGCCTCCCGGGGAGCTGGGACCACAGGCACGTGCCACCACACCCAGCTCTCTTTCTTGGTTTTTCATCATTTCAT
GTATCTATCAAAGCCCAGTTCACCTCCTCCCCCAAACACACACACACACACACACACACACACACACACACACAATTAAGTTGCTGCAAA
TTCAAAAGCTTAGAGAGAATAAGCTTCTTGGTGGTGAAACTACAACTCTCACGTGTGCTCCAGTTCTAAAATTAACCTGTGCCTGGTCTC
TGAAGCCCTTTCTTGCTCTGTGCCTTTCAGCCACATCCTTAGGTGCTAACGGCCATGAGCTCCGACTCTCCAAAGTGAGCTCCACTTTGG
GTCTGAGGAGCCCCTGGCAGAGTCCACGCTGCCTCAGGTATCATGGGCGTAATGATCACCCAGGCTCCGGGAGATCTCATGGATGATTAC
TGTATGAGACAGAGGGGACTTCAGTCTTTCCAGGGCCTTGGTGGAATTTTTGGCTCTGGTGTTTTCGCCAGACAATAAACTTACACTGGA
AGCTTTGATTCACCCTCCACAGTACTCCAGAAAGGACTGTCCTATAAGTTGTACACTTTAAAAGGTCATGTAGAGGTTGTAGTAGAATGG
CTTTTCACCCTGGTGACTTTGGAAGAAACTCTTGAATACTGCCTGCATCCGGGCACCATGGCCAGGTTGCCTAGGAGTGGGGTCCACTGA
TGAAAAGAGGTGTTTTGTACTTACATAAGAAAAATAAATTTCTGATTGATTTTAACCGTCATCTGCTTATATTTTGGGGGCCCCTCCTCA

>In-frame_ENST00000456148_ENST00000319332_TCGA-CN-A49A_TP63_chr3_189526315_+_LEPREL1_chr3_189713231_length(amino acids)=647AA_start in transcript=0_stop in transcript=1943
MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQS
STAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQALREYF
VEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKA
YLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSGVNVEGAE
VHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFEGATV
LKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYT
FRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQADEVIAILD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TP63-LEPREL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTP63chr3:189526315chr3:189713231ENST00000264731+414352_388193.0681.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000320472+412352_388193.0511.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000354600+212352_38899.0587.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000382063+113352_3880596.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000392460+413352_388193.0556.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000392461+210352_38899.0417.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000392463+211352_38899.0462.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000418709+411352_388193.0488.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000437221+29352_38899.0394.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000440651+414352_388193.0677.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000449992+111352_3880.0502.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000456148+212352_38899.0583.0HIPK2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TP63-LEPREL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TP63-LEPREL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTP63C1785148RAPP-HODGKIN SYNDROME7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneTP63C0406709Hay-Wells syndrome4CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneTP63C1858562ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 34CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneTP63C0008924Cleft upper lip3CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneTP63C0406704Rudiger syndrome 13CTD_human;ORPHANET
HgeneTP63C1863204ADULT SYNDROME3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneTP63C0024121Lung Neoplasms2CTD_human
HgeneTP63C0158646Cleft palate with cleft lip2ORPHANET
HgeneTP63C0242379Malignant neoplasm of lung2CTD_human
HgeneTP63C1298692Cleft lip and alveolus2ORPHANET
HgeneTP63C1851841ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 12ORPHANET
HgeneTP63C1854442SPLIT-HAND/FOOT MALFORMATION 42CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneTP63C0000772Multiple congenital anomalies1CTD_human
HgeneTP63C0001418Adenocarcinoma1CTD_human
HgeneTP63C0005689Bladder Exstrophy1ORPHANET
HgeneTP63C0006145Breast Diseases1CTD_human
HgeneTP63C0007097Carcinoma1CTD_human
HgeneTP63C0007137Squamous cell carcinoma1CTD_human
HgeneTP63C0007621Neoplastic Cell Transformation1CTD_human
HgeneTP63C0008925Cleft Palate1CTD_human
HgeneTP63C0009402Colorectal Carcinoma1CTD_human
HgeneTP63C0009404Colorectal Neoplasms1CTD_human
HgeneTP63C0016508Congenital Foot Deformity1CTD_human
HgeneTP63C0018566Congenital Hand Deformities1CTD_human
HgeneTP63C0027627Neoplasm Metastasis1CTD_human
HgeneTP63C0030297Pancreatic Neoplasm1CTD_human
HgeneTP63C0037268Skin Abnormalities1CTD_human
HgeneTP63C0038987Sweat Gland Neoplasms1CTD_human
HgeneTP63C0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneTP63C0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneTP63C0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneTP63C0205643Carcinoma, Cribriform1CTD_human
HgeneTP63C0205644Carcinoma, Granular Cell1CTD_human
HgeneTP63C0205645Adenocarcinoma, Tubular1CTD_human
HgeneTP63C0205696Anaplastic carcinoma1CTD_human
HgeneTP63C0205697Carcinoma, Spindle-Cell1CTD_human
HgeneTP63C0205698Undifferentiated carcinoma1CTD_human
HgeneTP63C0205699Carcinomatosis1CTD_human
HgeneTP63C0206720Squamous Cell Neoplasms1CTD_human
HgeneTP63C0206762Limb Deformities, Congenital1CTD_human
HgeneTP63C0265554Ectrodactyly1ORPHANET
HgeneTP63C0346647Malignant neoplasm of pancreas1CTD_human
HgeneTP63C0376634Craniofacial Abnormalities1CTD_human
HgeneTP63C0751688Malignant Squamous Cell Neoplasm1CTD_human
HgeneTP63C0919267ovarian neoplasm1CTD_human
HgeneTP63C1140680Malignant neoplasm of ovary1CTD_human;UNIPROT
HgeneTP63C1449718Endocrine Breast Diseases1CTD_human
HgeneTP63C1720887Female Urogenital Diseases1CTD_human
HgeneTP63C1837218Cleft palate, isolated1CTD_human
HgeneTP63C1851878OROFACIAL CLEFT 81UNIPROT
HgeneTP63C1863753LIMB-MAMMARY SYNDROME1CTD_human;GENOMICS_ENGLAND;ORPHANET