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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TPM1-COX20 (FusionGDB2 ID:92696)

Fusion Gene Summary for TPM1-COX20

check button Fusion gene summary
Fusion gene informationFusion gene name: TPM1-COX20
Fusion gene ID: 92696
HgeneTgene
Gene symbol

TPM1

COX20

Gene ID

7168

116228

Gene nametropomyosin 1cytochrome c oxidase assembly factor COX20
SynonymsC15orf13|CMD1Y|CMH3|HEL-S-265|HTM-alpha|LVNC9|TMSAFAM36A
Cytomap

15q22.2

1q44

Type of geneprotein-codingprotein-coding
Descriptiontropomyosin alpha-1 chaincardiomyopathy, hypertrophic 3epididymis secretory protein Li 265sarcomeric tropomyosin kappacytochrome c oxidase assembly protein COX20, mitochondrialCOX20 Cox2 chaperone homologCOX20, cytochrome c oxidase assembly factorcytochrome c oxidase protein 20 homologfamily with sequence similarity 36, member A
Modification date2020032020200320
UniProtAcc.

Q5RI15

Ensembl transtripts involved in fusion geneENST00000288398, ENST00000358278, 
ENST00000560445, ENST00000403994, 
ENST00000357980, ENST00000559556, 
ENST00000559397, ENST00000267996, 
ENST00000334895, ENST00000404484, 
ENST00000560959, ENST00000559281, 
ENST00000317516, 		ENST00000411948, 
ENST00000366528, ENST00000498262, 
Fusion gene scores* DoF score7 X 9 X 3=1893 X 5 X 2=30
# samples 85
** MAII scorelog2(8/189*10)=-1.24031432933371
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/30*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TPM1 [Title/Abstract] AND COX20 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTPM1(63336030)-COX20(245005245), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TPM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across COX20 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-HU-A4GP-11ATPM1chr15

63336030

+COX20chr1

245005245

+


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Fusion Gene ORF analysis for TPM1-COX20

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000288398ENST00000411948TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3CDSENST00000288398ENST00000366528TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3UTRENST00000288398ENST00000498262TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3CDSENST00000358278ENST00000411948TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3CDSENST00000358278ENST00000366528TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3UTRENST00000358278ENST00000498262TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3CDSENST00000560445ENST00000411948TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3CDSENST00000560445ENST00000366528TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3UTRENST00000560445ENST00000498262TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3CDSENST00000403994ENST00000411948TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3CDSENST00000403994ENST00000366528TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3UTRENST00000403994ENST00000498262TPM1chr15

63336030

+COX20chr1

245005245

+
In-frameENST00000357980ENST00000411948TPM1chr15

63336030

+COX20chr1

245005245

+
In-frameENST00000357980ENST00000366528TPM1chr15

63336030

+COX20chr1

245005245

+
5CDS-3UTRENST00000357980ENST00000498262TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3CDSENST00000559556ENST00000411948TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3CDSENST00000559556ENST00000366528TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3UTRENST00000559556ENST00000498262TPM1chr15

63336030

+COX20chr1

245005245

+
In-frameENST00000559397ENST00000411948TPM1chr15

63336030

+COX20chr1

245005245

+
In-frameENST00000559397ENST00000366528TPM1chr15

63336030

+COX20chr1

245005245

+
5CDS-3UTRENST00000559397ENST00000498262TPM1chr15

63336030

+COX20chr1

245005245

+
In-frameENST00000267996ENST00000411948TPM1chr15

63336030

+COX20chr1

245005245

+
In-frameENST00000267996ENST00000366528TPM1chr15

63336030

+COX20chr1

245005245

+
5CDS-3UTRENST00000267996ENST00000498262TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3CDSENST00000334895ENST00000411948TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3CDSENST00000334895ENST00000366528TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3UTRENST00000334895ENST00000498262TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3CDSENST00000404484ENST00000411948TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3CDSENST00000404484ENST00000366528TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3UTRENST00000404484ENST00000498262TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3CDSENST00000560959ENST00000411948TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3CDSENST00000560959ENST00000366528TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3UTRENST00000560959ENST00000498262TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3CDSENST00000559281ENST00000411948TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3CDSENST00000559281ENST00000366528TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3UTRENST00000559281ENST00000498262TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3CDSENST00000317516ENST00000411948TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3CDSENST00000317516ENST00000366528TPM1chr15

63336030

+COX20chr1

245005245

+
intron-3UTRENST00000317516ENST00000498262TPM1chr15

63336030

+COX20chr1

245005245

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357980TPM1chr1563336030+ENST00000411948COX20chr1245005245+251531979633184
ENST00000357980TPM1chr1563336030+ENST00000366528COX20chr1245005245+71031979633184
ENST00000559397TPM1chr1563336030+ENST00000411948COX20chr1245005245+250831272626184
ENST00000559397TPM1chr1563336030+ENST00000366528COX20chr1245005245+70331272626184
ENST00000267996TPM1chr1563336030+ENST00000411948COX20chr1245005245+250831272626184
ENST00000267996TPM1chr1563336030+ENST00000366528COX20chr1245005245+70331272626184

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357980ENST00000411948TPM1chr1563336030+COX20chr1245005245+0.0009573480.9990426
ENST00000357980ENST00000366528TPM1chr1563336030+COX20chr1245005245+0.0001614680.9998385
ENST00000559397ENST00000411948TPM1chr1563336030+COX20chr1245005245+0.0008738590.99912614
ENST00000559397ENST00000366528TPM1chr1563336030+COX20chr1245005245+0.0001697060.99983025
ENST00000267996ENST00000411948TPM1chr1563336030+COX20chr1245005245+0.0008738590.99912614
ENST00000267996ENST00000366528TPM1chr1563336030+COX20chr1245005245+0.0001697060.99983025

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Fusion Genomic Features for TPM1-COX20


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TPM1chr1563336030+COX20chr1245005245+2.36E-050.9999764
TPM1chr1563336030+COX20chr1245005245+2.36E-050.9999764

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TPM1-COX20


check button Go to

FGviewer for the breakpoints of chr15:63336030-chr1:245005245

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.COX20

Q5RI15

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:23125284). Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme (PubMed:24403053). {ECO:0000269|PubMed:23125284, ECO:0000269|PubMed:24403053}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOX20chr15:63336030chr1:245005245ENST000003665281552_6026.0131.0Topological domainMitochondrial matrix
TgeneCOX20chr15:63336030chr1:245005245ENST000003665281578_11826.0131.0Topological domainMitochondrial intermembrane
TgeneCOX20chr15:63336030chr1:245005245ENST000004119480452_6014.0119.0Topological domainMitochondrial matrix
TgeneCOX20chr15:63336030chr1:245005245ENST000004119480478_11814.0119.0Topological domainMitochondrial intermembrane
TgeneCOX20chr15:63336030chr1:245005245ENST000003665281534_5126.0131.0TransmembraneHelical
TgeneCOX20chr15:63336030chr1:245005245ENST000003665281561_7726.0131.0TransmembraneHelical
TgeneCOX20chr15:63336030chr1:245005245ENST000004119480434_5114.0119.0TransmembraneHelical
TgeneCOX20chr15:63336030chr1:245005245ENST000004119480461_7714.0119.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTPM1chr15:63336030chr1:245005245ENST00000267996+291_28480.0285.0Coiled coilOntology_term=ECO:0000250
HgeneTPM1chr15:63336030chr1:245005245ENST00000288398+1101_2840247.0Coiled coilOntology_term=ECO:0000250
HgeneTPM1chr15:63336030chr1:245005245ENST00000334895+181_2840246.0Coiled coilOntology_term=ECO:0000250
HgeneTPM1chr15:63336030chr1:245005245ENST00000358278+191_2840285.0Coiled coilOntology_term=ECO:0000250
HgeneTPM1chr15:63336030chr1:245005245ENST00000403994+1101_2840285.0Coiled coilOntology_term=ECO:0000250
HgeneTPM1chr15:63336030chr1:245005245ENST00000559397+291_28480.0285.0Coiled coilOntology_term=ECO:0000250
HgeneTPM1chr15:63336030chr1:245005245ENST00000559556+191_2840285.0Coiled coilOntology_term=ECO:0000250
TgeneCOX20chr15:63336030chr1:245005245ENST00000366528152_3326.0131.0Topological domainMitochondrial intermembrane
TgeneCOX20chr15:63336030chr1:245005245ENST00000411948042_3314.0119.0Topological domainMitochondrial intermembrane


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Fusion Gene Sequence for TPM1-COX20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000357980_ENST00000411948_TCGA-HU-A4GP-11A_TPM1_chr15_63336030_+_COX20_chr1_245005245_length(transcript)=2515nt_BP=319nt
GCACTCCCGCTCCTCCGCCCGACCGCGCGCTCGCCCCGCCGCTCCTGCTGCAGCCCCAGGGCCCCTCGCCGCCGCCACCATGGACGCCAT
CAAGAAGAAGATGCAGATGCTGAAGCTCGACAAGGAGAACGCCTTGGATCGAGCTGAGCAGGCGGAGGCCGACAAGAAGGCGGCGGAAGA
CAGGAGCAAGCAGCTCGAGGAGGACATCGCGGCCAAGGAGAAGTTGCTGCGGGTGTCGGAGGACGAGCGGGACCGGGTGCTGGAGGAGCT
GCACAAGGCGGAGGACAGCCTCCTGGCCGCCGAAGAGGCCGCCGCCAAGTCCCTTAAGCTCCTAGGATTTTTAGATGTTGAAAATACTCC
CTGCGCCCGGCATTCAATATTGTATGGTTCATTAGGATCTGTTGTGGCTGGCTTTGGACATTTTTTGTTCACTAGTAGAATTAGAAGATC
ATGTGATGTTGGAGTAGGAGGGTTTATCTTGGTGACTTTGGGATGCTGGTTTCATTGTAGGTATAATTATGCAAAGCAAAGAATCCAGGA
AAGAATTGCCAGAGAAGAAATTAAAAAGAAGATATTATATGAAGGTACCCACCTCGATCCTGAAAGAAAACACAACGGCAGCAGCAGCAA
TTGAACAATCTTGAGCATAGAAGTCAATGTAAACGAAGTTAAGATCAACCACATAAAACATTTCATGTGCAATAAGCTCTCAATCAAGTA
AATAAAGTTTAAGTTGTAGTCATTTTTTTCCCACACTTGTGTGGAATGAAAACTTGCCAGTTTATTCTGGCCCTGTGTCTACTGCCAGGA
TAGCATTCTTACGTGTTACATATAGTGGACTTGTCATCCTTAAAATGTGAACAGAATTTATTGGCAGTGTGGCAAAGAATTATAAAACAT
AGTGTTTAATGTACTTGGAGTTTCCTTGTAGTAGTAAGTATAGAGTTTGATGATAAGTAAACGTCCCTTAACAAAAACCTCAACCTTATT
ACTATCCCATTAAAAAACAGCAAATACTTACTGAGTTCTTGTAAGAGCTAATGTCATTGTAAGATTTAAAACTAAGGGCTTTTATCACTT
TGCAAATTATTTTTTAAATGCATTCATCATTTGACAGTGTTCTCTCATTTCTTAAAATGCGAGTCATCTTCCAAAAGAGTTGTTTTTAAC
TGCCCTAAACATTTTTGGGGAAGTATGCAGGGTTTAAATTTTTAAGTATAATTAGTTCTGAATTAAAATATGCACATGGAACTTGTCTGG
CAGACTGATGCAATAGTAAAACAACTGCAGAATTACTATTAATGTAAACAATCCATTTGAAAGTCAATCAGCTGCTCCCATTAAAATATT
ATTTAAAATACAATACCCACAGCATCTAACTAAATCCTCAGGATTTATTCTCCGGGAGAAATTATCCCTTTCTAGGAAAATGAAGTTATT
TCTGGTTTTAATTCATACAATACTTTAAGAAAATCTGTTAAATATAACAAAACACAAGCTAGATGCTTAAGAAATGCTTAAAGAAATATT
GGGGCGAAGGTAACAGCAGTCAACAGGATTGTGGCCATTACTGGTCCTATTATTTTGATGTACCATGGAAGGCACAGAAATCGAGCAAGG
AAGAAAATATTAGTTATTTTGATCTACATCTTTTTCTAAAGAAAAGTGGAGCTTGCCTCCAGTTCAATTCACAAGAGCATTTTCCCTCCC
ATGCCCACCTTTTCTTGTGGCTGTCGCTAGGAAGGATGCAGAGGCTGTGTGGTTTACCAAATGCCTTAACTTAGCAGTGAATGACAACTG
TCAAACACATGTTGAGGGAAAATTTTTACTGATTCACAAAAAGGAAGACAGTTTGCCCACTCTTAGTGGCACAAATCAAAGCTGCATGCA
CTACATTATCCAAATTAGTCGTAACCAAATAGTTAAAAAATTCTGCTGGGCACGGTGGCTCATACCTGTAATCCCAGCACTTTGGGAGGC
CGAGGCAGTTGGATCACCTGAGGTTAGGAGTTTGAGACCAGCCTGGCCAACAGGGTGAAACCCTGTCTCGTCTAAAAATACAAAAATTAG
CCGGGCGTGGTGGTGCATGCCTGTAGTCCCAGGTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCGAGGTGGGGCAGGCGGAGGT
TGCAGTAAGCCAAGATCGCGCCATTGCACTCTAGCCTAGGTGACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAATTCCATAGGATGT
TCAACCATGTTTTCAGAGGCCGCACTGCATGAATGCGGGAAAATGTTGATGATCACTAATCAATAATCTGATATTTAACAAAATATGGAC
AGGCCACTTATGCTCAGTTTTACCTTAGTTATTCCTTGGTATCCACAGGCCCAAGTCCCTTTAAATAAAATACCCTCATATTTCCATATA

>In-frame_ENST00000357980_ENST00000411948_TCGA-HU-A4GP-11A_TPM1_chr15_63336030_+_COX20_chr1_245005245_length(amino acids)=184AA_start in transcript=79_stop in transcript=633
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKSLKLLGFLDV
ENTPCARHSILYGSLGSVVAGFGHFLFTSRIRRSCDVGVGGFILVTLGCWFHCRYNYAKQRIQERIAREEIKKKILYEGTHLDPERKHNG

--------------------------------------------------------------
>In-frame_ENST00000357980_ENST00000366528_TCGA-HU-A4GP-11A_TPM1_chr15_63336030_+_COX20_chr1_245005245_length(transcript)=710nt_BP=319nt
GCACTCCCGCTCCTCCGCCCGACCGCGCGCTCGCCCCGCCGCTCCTGCTGCAGCCCCAGGGCCCCTCGCCGCCGCCACCATGGACGCCAT
CAAGAAGAAGATGCAGATGCTGAAGCTCGACAAGGAGAACGCCTTGGATCGAGCTGAGCAGGCGGAGGCCGACAAGAAGGCGGCGGAAGA
CAGGAGCAAGCAGCTCGAGGAGGACATCGCGGCCAAGGAGAAGTTGCTGCGGGTGTCGGAGGACGAGCGGGACCGGGTGCTGGAGGAGCT
GCACAAGGCGGAGGACAGCCTCCTGGCCGCCGAAGAGGCCGCCGCCAAGTCCCTTAAGCTCCTAGGATTTTTAGATGTTGAAAATACTCC
CTGCGCCCGGCATTCAATATTGTATGGTTCATTAGGATCTGTTGTGGCTGGCTTTGGACATTTTTTGTTCACTAGTAGAATTAGAAGATC
ATGTGATGTTGGAGTAGGAGGGTTTATCTTGGTGACTTTGGGATGCTGGTTTCATTGTAGGTATAATTATGCAAAGCAAAGAATCCAGGA
AAGAATTGCCAGAGAAGAAATTAAAAAGAAGATATTATATGAAGGTACCCACCTCGATCCTGAAAGAAAACACAACGGCAGCAGCAGCAA

>In-frame_ENST00000357980_ENST00000366528_TCGA-HU-A4GP-11A_TPM1_chr15_63336030_+_COX20_chr1_245005245_length(amino acids)=184AA_start in transcript=79_stop in transcript=633
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKSLKLLGFLDV
ENTPCARHSILYGSLGSVVAGFGHFLFTSRIRRSCDVGVGGFILVTLGCWFHCRYNYAKQRIQERIAREEIKKKILYEGTHLDPERKHNG

--------------------------------------------------------------
>In-frame_ENST00000559397_ENST00000411948_TCGA-HU-A4GP-11A_TPM1_chr15_63336030_+_COX20_chr1_245005245_length(transcript)=2508nt_BP=312nt
CGCTCCTCCGCCCGACCGCGCGCTCGCCCCGCCGCTCCTGCTGCAGCCCCAGGGCCCCTCGCCGCCGCCACCATGGACGCCATCAAGAAG
AAGATGCAGATGCTGAAGCTCGACAAGGAGAACGCCTTGGATCGAGCTGAGCAGGCGGAGGCCGACAAGAAGGCGGCGGAAGACAGGAGC
AAGCAGCTCGAGGAGGACATCGCGGCCAAGGAGAAGTTGCTGCGGGTGTCGGAGGACGAGCGGGACCGGGTGCTGGAGGAGCTGCACAAG
GCGGAGGACAGCCTCCTGGCCGCCGAAGAGGCCGCCGCCAAGTCCCTTAAGCTCCTAGGATTTTTAGATGTTGAAAATACTCCCTGCGCC
CGGCATTCAATATTGTATGGTTCATTAGGATCTGTTGTGGCTGGCTTTGGACATTTTTTGTTCACTAGTAGAATTAGAAGATCATGTGAT
GTTGGAGTAGGAGGGTTTATCTTGGTGACTTTGGGATGCTGGTTTCATTGTAGGTATAATTATGCAAAGCAAAGAATCCAGGAAAGAATT
GCCAGAGAAGAAATTAAAAAGAAGATATTATATGAAGGTACCCACCTCGATCCTGAAAGAAAACACAACGGCAGCAGCAGCAATTGAACA
ATCTTGAGCATAGAAGTCAATGTAAACGAAGTTAAGATCAACCACATAAAACATTTCATGTGCAATAAGCTCTCAATCAAGTAAATAAAG
TTTAAGTTGTAGTCATTTTTTTCCCACACTTGTGTGGAATGAAAACTTGCCAGTTTATTCTGGCCCTGTGTCTACTGCCAGGATAGCATT
CTTACGTGTTACATATAGTGGACTTGTCATCCTTAAAATGTGAACAGAATTTATTGGCAGTGTGGCAAAGAATTATAAAACATAGTGTTT
AATGTACTTGGAGTTTCCTTGTAGTAGTAAGTATAGAGTTTGATGATAAGTAAACGTCCCTTAACAAAAACCTCAACCTTATTACTATCC
CATTAAAAAACAGCAAATACTTACTGAGTTCTTGTAAGAGCTAATGTCATTGTAAGATTTAAAACTAAGGGCTTTTATCACTTTGCAAAT
TATTTTTTAAATGCATTCATCATTTGACAGTGTTCTCTCATTTCTTAAAATGCGAGTCATCTTCCAAAAGAGTTGTTTTTAACTGCCCTA
AACATTTTTGGGGAAGTATGCAGGGTTTAAATTTTTAAGTATAATTAGTTCTGAATTAAAATATGCACATGGAACTTGTCTGGCAGACTG
ATGCAATAGTAAAACAACTGCAGAATTACTATTAATGTAAACAATCCATTTGAAAGTCAATCAGCTGCTCCCATTAAAATATTATTTAAA
ATACAATACCCACAGCATCTAACTAAATCCTCAGGATTTATTCTCCGGGAGAAATTATCCCTTTCTAGGAAAATGAAGTTATTTCTGGTT
TTAATTCATACAATACTTTAAGAAAATCTGTTAAATATAACAAAACACAAGCTAGATGCTTAAGAAATGCTTAAAGAAATATTGGGGCGA
AGGTAACAGCAGTCAACAGGATTGTGGCCATTACTGGTCCTATTATTTTGATGTACCATGGAAGGCACAGAAATCGAGCAAGGAAGAAAA
TATTAGTTATTTTGATCTACATCTTTTTCTAAAGAAAAGTGGAGCTTGCCTCCAGTTCAATTCACAAGAGCATTTTCCCTCCCATGCCCA
CCTTTTCTTGTGGCTGTCGCTAGGAAGGATGCAGAGGCTGTGTGGTTTACCAAATGCCTTAACTTAGCAGTGAATGACAACTGTCAAACA
CATGTTGAGGGAAAATTTTTACTGATTCACAAAAAGGAAGACAGTTTGCCCACTCTTAGTGGCACAAATCAAAGCTGCATGCACTACATT
ATCCAAATTAGTCGTAACCAAATAGTTAAAAAATTCTGCTGGGCACGGTGGCTCATACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCA
GTTGGATCACCTGAGGTTAGGAGTTTGAGACCAGCCTGGCCAACAGGGTGAAACCCTGTCTCGTCTAAAAATACAAAAATTAGCCGGGCG
TGGTGGTGCATGCCTGTAGTCCCAGGTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCGAGGTGGGGCAGGCGGAGGTTGCAGTA
AGCCAAGATCGCGCCATTGCACTCTAGCCTAGGTGACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAATTCCATAGGATGTTCAACCA
TGTTTTCAGAGGCCGCACTGCATGAATGCGGGAAAATGTTGATGATCACTAATCAATAATCTGATATTTAACAAAATATGGACAGGCCAC
TTATGCTCAGTTTTACCTTAGTTATTCCTTGGTATCCACAGGCCCAAGTCCCTTTAAATAAAATACCCTCATATTTCCATATAATCTACA

>In-frame_ENST00000559397_ENST00000411948_TCGA-HU-A4GP-11A_TPM1_chr15_63336030_+_COX20_chr1_245005245_length(amino acids)=184AA_start in transcript=72_stop in transcript=626
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKSLKLLGFLDV
ENTPCARHSILYGSLGSVVAGFGHFLFTSRIRRSCDVGVGGFILVTLGCWFHCRYNYAKQRIQERIAREEIKKKILYEGTHLDPERKHNG

--------------------------------------------------------------
>In-frame_ENST00000559397_ENST00000366528_TCGA-HU-A4GP-11A_TPM1_chr15_63336030_+_COX20_chr1_245005245_length(transcript)=703nt_BP=312nt
CGCTCCTCCGCCCGACCGCGCGCTCGCCCCGCCGCTCCTGCTGCAGCCCCAGGGCCCCTCGCCGCCGCCACCATGGACGCCATCAAGAAG
AAGATGCAGATGCTGAAGCTCGACAAGGAGAACGCCTTGGATCGAGCTGAGCAGGCGGAGGCCGACAAGAAGGCGGCGGAAGACAGGAGC
AAGCAGCTCGAGGAGGACATCGCGGCCAAGGAGAAGTTGCTGCGGGTGTCGGAGGACGAGCGGGACCGGGTGCTGGAGGAGCTGCACAAG
GCGGAGGACAGCCTCCTGGCCGCCGAAGAGGCCGCCGCCAAGTCCCTTAAGCTCCTAGGATTTTTAGATGTTGAAAATACTCCCTGCGCC
CGGCATTCAATATTGTATGGTTCATTAGGATCTGTTGTGGCTGGCTTTGGACATTTTTTGTTCACTAGTAGAATTAGAAGATCATGTGAT
GTTGGAGTAGGAGGGTTTATCTTGGTGACTTTGGGATGCTGGTTTCATTGTAGGTATAATTATGCAAAGCAAAGAATCCAGGAAAGAATT
GCCAGAGAAGAAATTAAAAAGAAGATATTATATGAAGGTACCCACCTCGATCCTGAAAGAAAACACAACGGCAGCAGCAGCAATTGAACA

>In-frame_ENST00000559397_ENST00000366528_TCGA-HU-A4GP-11A_TPM1_chr15_63336030_+_COX20_chr1_245005245_length(amino acids)=184AA_start in transcript=72_stop in transcript=626
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKSLKLLGFLDV
ENTPCARHSILYGSLGSVVAGFGHFLFTSRIRRSCDVGVGGFILVTLGCWFHCRYNYAKQRIQERIAREEIKKKILYEGTHLDPERKHNG

--------------------------------------------------------------
>In-frame_ENST00000267996_ENST00000411948_TCGA-HU-A4GP-11A_TPM1_chr15_63336030_+_COX20_chr1_245005245_length(transcript)=2508nt_BP=312nt
CGCTCCTCCGCCCGACCGCGCGCTCGCCCCGCCGCTCCTGCTGCAGCCCCAGGGCCCCTCGCCGCCGCCACCATGGACGCCATCAAGAAG
AAGATGCAGATGCTGAAGCTCGACAAGGAGAACGCCTTGGATCGAGCTGAGCAGGCGGAGGCCGACAAGAAGGCGGCGGAAGACAGGAGC
AAGCAGCTCGAGGAGGACATCGCGGCCAAGGAGAAGTTGCTGCGGGTGTCGGAGGACGAGCGGGACCGGGTGCTGGAGGAGCTGCACAAG
GCGGAGGACAGCCTCCTGGCCGCCGAAGAGGCCGCCGCCAAGTCCCTTAAGCTCCTAGGATTTTTAGATGTTGAAAATACTCCCTGCGCC
CGGCATTCAATATTGTATGGTTCATTAGGATCTGTTGTGGCTGGCTTTGGACATTTTTTGTTCACTAGTAGAATTAGAAGATCATGTGAT
GTTGGAGTAGGAGGGTTTATCTTGGTGACTTTGGGATGCTGGTTTCATTGTAGGTATAATTATGCAAAGCAAAGAATCCAGGAAAGAATT
GCCAGAGAAGAAATTAAAAAGAAGATATTATATGAAGGTACCCACCTCGATCCTGAAAGAAAACACAACGGCAGCAGCAGCAATTGAACA
ATCTTGAGCATAGAAGTCAATGTAAACGAAGTTAAGATCAACCACATAAAACATTTCATGTGCAATAAGCTCTCAATCAAGTAAATAAAG
TTTAAGTTGTAGTCATTTTTTTCCCACACTTGTGTGGAATGAAAACTTGCCAGTTTATTCTGGCCCTGTGTCTACTGCCAGGATAGCATT
CTTACGTGTTACATATAGTGGACTTGTCATCCTTAAAATGTGAACAGAATTTATTGGCAGTGTGGCAAAGAATTATAAAACATAGTGTTT
AATGTACTTGGAGTTTCCTTGTAGTAGTAAGTATAGAGTTTGATGATAAGTAAACGTCCCTTAACAAAAACCTCAACCTTATTACTATCC
CATTAAAAAACAGCAAATACTTACTGAGTTCTTGTAAGAGCTAATGTCATTGTAAGATTTAAAACTAAGGGCTTTTATCACTTTGCAAAT
TATTTTTTAAATGCATTCATCATTTGACAGTGTTCTCTCATTTCTTAAAATGCGAGTCATCTTCCAAAAGAGTTGTTTTTAACTGCCCTA
AACATTTTTGGGGAAGTATGCAGGGTTTAAATTTTTAAGTATAATTAGTTCTGAATTAAAATATGCACATGGAACTTGTCTGGCAGACTG
ATGCAATAGTAAAACAACTGCAGAATTACTATTAATGTAAACAATCCATTTGAAAGTCAATCAGCTGCTCCCATTAAAATATTATTTAAA
ATACAATACCCACAGCATCTAACTAAATCCTCAGGATTTATTCTCCGGGAGAAATTATCCCTTTCTAGGAAAATGAAGTTATTTCTGGTT
TTAATTCATACAATACTTTAAGAAAATCTGTTAAATATAACAAAACACAAGCTAGATGCTTAAGAAATGCTTAAAGAAATATTGGGGCGA
AGGTAACAGCAGTCAACAGGATTGTGGCCATTACTGGTCCTATTATTTTGATGTACCATGGAAGGCACAGAAATCGAGCAAGGAAGAAAA
TATTAGTTATTTTGATCTACATCTTTTTCTAAAGAAAAGTGGAGCTTGCCTCCAGTTCAATTCACAAGAGCATTTTCCCTCCCATGCCCA
CCTTTTCTTGTGGCTGTCGCTAGGAAGGATGCAGAGGCTGTGTGGTTTACCAAATGCCTTAACTTAGCAGTGAATGACAACTGTCAAACA
CATGTTGAGGGAAAATTTTTACTGATTCACAAAAAGGAAGACAGTTTGCCCACTCTTAGTGGCACAAATCAAAGCTGCATGCACTACATT
ATCCAAATTAGTCGTAACCAAATAGTTAAAAAATTCTGCTGGGCACGGTGGCTCATACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCA
GTTGGATCACCTGAGGTTAGGAGTTTGAGACCAGCCTGGCCAACAGGGTGAAACCCTGTCTCGTCTAAAAATACAAAAATTAGCCGGGCG
TGGTGGTGCATGCCTGTAGTCCCAGGTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCGAGGTGGGGCAGGCGGAGGTTGCAGTA
AGCCAAGATCGCGCCATTGCACTCTAGCCTAGGTGACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAATTCCATAGGATGTTCAACCA
TGTTTTCAGAGGCCGCACTGCATGAATGCGGGAAAATGTTGATGATCACTAATCAATAATCTGATATTTAACAAAATATGGACAGGCCAC
TTATGCTCAGTTTTACCTTAGTTATTCCTTGGTATCCACAGGCCCAAGTCCCTTTAAATAAAATACCCTCATATTTCCATATAATCTACA

>In-frame_ENST00000267996_ENST00000411948_TCGA-HU-A4GP-11A_TPM1_chr15_63336030_+_COX20_chr1_245005245_length(amino acids)=184AA_start in transcript=72_stop in transcript=626
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKSLKLLGFLDV
ENTPCARHSILYGSLGSVVAGFGHFLFTSRIRRSCDVGVGGFILVTLGCWFHCRYNYAKQRIQERIAREEIKKKILYEGTHLDPERKHNG

--------------------------------------------------------------
>In-frame_ENST00000267996_ENST00000366528_TCGA-HU-A4GP-11A_TPM1_chr15_63336030_+_COX20_chr1_245005245_length(transcript)=703nt_BP=312nt
CGCTCCTCCGCCCGACCGCGCGCTCGCCCCGCCGCTCCTGCTGCAGCCCCAGGGCCCCTCGCCGCCGCCACCATGGACGCCATCAAGAAG
AAGATGCAGATGCTGAAGCTCGACAAGGAGAACGCCTTGGATCGAGCTGAGCAGGCGGAGGCCGACAAGAAGGCGGCGGAAGACAGGAGC
AAGCAGCTCGAGGAGGACATCGCGGCCAAGGAGAAGTTGCTGCGGGTGTCGGAGGACGAGCGGGACCGGGTGCTGGAGGAGCTGCACAAG
GCGGAGGACAGCCTCCTGGCCGCCGAAGAGGCCGCCGCCAAGTCCCTTAAGCTCCTAGGATTTTTAGATGTTGAAAATACTCCCTGCGCC
CGGCATTCAATATTGTATGGTTCATTAGGATCTGTTGTGGCTGGCTTTGGACATTTTTTGTTCACTAGTAGAATTAGAAGATCATGTGAT
GTTGGAGTAGGAGGGTTTATCTTGGTGACTTTGGGATGCTGGTTTCATTGTAGGTATAATTATGCAAAGCAAAGAATCCAGGAAAGAATT
GCCAGAGAAGAAATTAAAAAGAAGATATTATATGAAGGTACCCACCTCGATCCTGAAAGAAAACACAACGGCAGCAGCAGCAATTGAACA

>In-frame_ENST00000267996_ENST00000366528_TCGA-HU-A4GP-11A_TPM1_chr15_63336030_+_COX20_chr1_245005245_length(amino acids)=184AA_start in transcript=72_stop in transcript=626
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKSLKLLGFLDV
ENTPCARHSILYGSLGSVVAGFGHFLFTSRIRRSCDVGVGGFILVTLGCWFHCRYNYAKQRIQERIAREEIKKKILYEGTHLDPERKHNG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TPM1-COX20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TPM1-COX20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TPM1-COX20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTPM1C0007194Hypertrophic Cardiomyopathy18CLINGEN
HgeneTPM1C1861863CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 3 (disorder)9CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneTPM1C2678476Cardiomyopathy, Dilated, 1y5CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneTPM1C0014859Esophageal Neoplasms1CTD_human
HgeneTPM1C0020538Hypertensive disease1CTD_human
HgeneTPM1C0022548Keloid1CTD_human
HgeneTPM1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneTPM1C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneTPM1C0340427Familial dilated cardiomyopathy1ORPHANET
HgeneTPM1C0546837Malignant neoplasm of esophagus1CTD_human
HgeneTPM1C0597124Obstructive asymmetric septal hypertrophy1CTD_human
HgeneTPM1C0700053Idiopathic hypertrophic subaortic stenosis1CTD_human
HgeneTPM1C0949658Cardiomyopathy, Hypertrophic, Familial1CTD_human
HgeneTPM1C1960469Left ventricular noncompaction1ORPHANET
TgeneCOX20C0268237Cytochrome-c Oxidase Deficiency4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT