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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRA2A-ATP2A2 (FusionGDB2 ID:92936)

Fusion Gene Summary for TRA2A-ATP2A2

check button Fusion gene summary
Fusion gene informationFusion gene name: TRA2A-ATP2A2
Fusion gene ID: 92936
HgeneTgene
Gene symbol

TRA2A

ATP2A2

Gene ID

29896

488

Gene nametransformer 2 alpha homologATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
SynonymsAWMS1|HSU53209ATP2B|DAR|DD|SERCA2
Cytomap

7p15.3

12q24.11

Type of geneprotein-codingprotein-coding
Descriptiontransformer-2 protein homolog alphaTRA-2 alphaTRA2-alphaTra2alphahtra-2 alphaputative MAPK activating protein PM24transformer-2 alphatransformer-2 protein homolog Asarcoplasmic/endoplasmic reticulum calcium ATPase 2ATPase Ca++ transporting cardiac muscle slow twitch 2ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2SR Ca(2+)-ATPase 2calcium pump 2calcium-transporting ATPase sarcoplasmic reticulum type, slow
Modification date2020031320200313
UniProtAcc.

P16615

Ensembl transtripts involved in fusion geneENST00000297071, ENST00000392502, 
ENST00000538367, ENST00000474586, 
ENST00000308664, ENST00000395494, 
ENST00000539276, ENST00000550248, 
ENST00000552636, 
Fusion gene scores* DoF score20 X 14 X 9=252019 X 23 X 6=2622
# samples 2423
** MAII scorelog2(24/2520*10)=-3.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/2622*10)=-3.51096191927738
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRA2A [Title/Abstract] AND ATP2A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRA2A(23571407)-ATP2A2(110729824), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRA2A

GO:0000398

mRNA splicing, via spliceosome

9546399

TgeneATP2A2

GO:0032469

endoplasmic reticulum calcium ion homeostasis

16402920

TgeneATP2A2

GO:0032470

positive regulation of endoplasmic reticulum calcium ion concentration

16402920

TgeneATP2A2

GO:0070588

calcium ion transmembrane transport

16402920

TgeneATP2A2

GO:1903515

calcium ion transport from cytosol to endoplasmic reticulum

16402920


check buttonFusion gene breakpoints across TRA2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ATP2A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A43MTRA2Achr7

23571407

-ATP2A2chr12

110729824

+


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Fusion Gene ORF analysis for TRA2A-ATP2A2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000297071ENST00000308664TRA2Achr7

23571407

-ATP2A2chr12

110729824

+
In-frameENST00000297071ENST00000395494TRA2Achr7

23571407

-ATP2A2chr12

110729824

+
In-frameENST00000297071ENST00000539276TRA2Achr7

23571407

-ATP2A2chr12

110729824

+
5CDS-intronENST00000297071ENST00000550248TRA2Achr7

23571407

-ATP2A2chr12

110729824

+
5CDS-5UTRENST00000297071ENST00000552636TRA2Achr7

23571407

-ATP2A2chr12

110729824

+
5UTR-3CDSENST00000392502ENST00000308664TRA2Achr7

23571407

-ATP2A2chr12

110729824

+
5UTR-3CDSENST00000392502ENST00000395494TRA2Achr7

23571407

-ATP2A2chr12

110729824

+
5UTR-3CDSENST00000392502ENST00000539276TRA2Achr7

23571407

-ATP2A2chr12

110729824

+
5UTR-intronENST00000392502ENST00000550248TRA2Achr7

23571407

-ATP2A2chr12

110729824

+
5UTR-5UTRENST00000392502ENST00000552636TRA2Achr7

23571407

-ATP2A2chr12

110729824

+
5UTR-3CDSENST00000538367ENST00000308664TRA2Achr7

23571407

-ATP2A2chr12

110729824

+
5UTR-3CDSENST00000538367ENST00000395494TRA2Achr7

23571407

-ATP2A2chr12

110729824

+
5UTR-3CDSENST00000538367ENST00000539276TRA2Achr7

23571407

-ATP2A2chr12

110729824

+
5UTR-intronENST00000538367ENST00000550248TRA2Achr7

23571407

-ATP2A2chr12

110729824

+
5UTR-5UTRENST00000538367ENST00000552636TRA2Achr7

23571407

-ATP2A2chr12

110729824

+
intron-3CDSENST00000474586ENST00000308664TRA2Achr7

23571407

-ATP2A2chr12

110729824

+
intron-3CDSENST00000474586ENST00000395494TRA2Achr7

23571407

-ATP2A2chr12

110729824

+
intron-3CDSENST00000474586ENST00000539276TRA2Achr7

23571407

-ATP2A2chr12

110729824

+
intron-intronENST00000474586ENST00000550248TRA2Achr7

23571407

-ATP2A2chr12

110729824

+
intron-5UTRENST00000474586ENST00000552636TRA2Achr7

23571407

-ATP2A2chr12

110729824

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000297071TRA2Achr723571407-ENST00000308664ATP2A2chr12110729824+38132532173027936
ENST00000297071TRA2Achr723571407-ENST00000395494ATP2A2chr12110729824+77002532173081954
ENST00000297071TRA2Achr723571407-ENST00000539276ATP2A2chr12110729824+40192532173162981

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000297071ENST00000308664TRA2Achr723571407-ATP2A2chr12110729824+0.0004001050.9995999
ENST00000297071ENST00000395494TRA2Achr723571407-ATP2A2chr12110729824+0.0004220410.99957794
ENST00000297071ENST00000539276TRA2Achr723571407-ATP2A2chr12110729824+0.0003057580.9996942

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Fusion Genomic Features for TRA2A-ATP2A2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TRA2Achr723571407-ATP2A2chr12110729824+3.76E-091
TRA2Achr723571407-ATP2A2chr12110729824+3.76E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRA2A-ATP2A2


check button Go to

FGviewer for the breakpoints of chr7:23571407-chr12:110729824

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ATP2A2

P16615

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). {ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneATP2A2chr7:23571407chr12:110729824ENST00000308664221111_25373.0998.0Topological domainCytoplasmic
TgeneATP2A2chr7:23571407chr12:110729824ENST00000308664221274_29573.0998.0Topological domainLumenal
TgeneATP2A2chr7:23571407chr12:110729824ENST00000308664221314_75673.0998.0Topological domainCytoplasmic
TgeneATP2A2chr7:23571407chr12:110729824ENST0000030866422170_8973.0998.0Topological domainLumenal
TgeneATP2A2chr7:23571407chr12:110729824ENST00000308664221777_78673.0998.0Topological domainLumenal
TgeneATP2A2chr7:23571407chr12:110729824ENST00000308664221808_82773.0998.0Topological domainCytoplasmic
TgeneATP2A2chr7:23571407chr12:110729824ENST00000308664221851_89673.0998.0Topological domainLumenal
TgeneATP2A2chr7:23571407chr12:110729824ENST00000308664221917_92973.0998.0Topological domainCytoplasmic
TgeneATP2A2chr7:23571407chr12:110729824ENST00000308664221949_96373.0998.0Topological domainLumenal
TgeneATP2A2chr7:23571407chr12:110729824ENST00000308664221985_104273.0998.0Topological domainCytoplasmic
TgeneATP2A2chr7:23571407chr12:110729824ENST00000395494219111_25373.01016.0Topological domainCytoplasmic
TgeneATP2A2chr7:23571407chr12:110729824ENST00000395494219274_29573.01016.0Topological domainLumenal
TgeneATP2A2chr7:23571407chr12:110729824ENST00000395494219314_75673.01016.0Topological domainCytoplasmic
TgeneATP2A2chr7:23571407chr12:110729824ENST0000039549421970_8973.01016.0Topological domainLumenal
TgeneATP2A2chr7:23571407chr12:110729824ENST00000395494219777_78673.01016.0Topological domainLumenal
TgeneATP2A2chr7:23571407chr12:110729824ENST00000395494219808_82773.01016.0Topological domainCytoplasmic
TgeneATP2A2chr7:23571407chr12:110729824ENST00000395494219851_89673.01016.0Topological domainLumenal
TgeneATP2A2chr7:23571407chr12:110729824ENST00000395494219917_92973.01016.0Topological domainCytoplasmic
TgeneATP2A2chr7:23571407chr12:110729824ENST00000395494219949_96373.01016.0Topological domainLumenal
TgeneATP2A2chr7:23571407chr12:110729824ENST00000395494219985_104273.01016.0Topological domainCytoplasmic
TgeneATP2A2chr7:23571407chr12:110729824ENST00000539276220111_25373.01043.0Topological domainCytoplasmic
TgeneATP2A2chr7:23571407chr12:110729824ENST00000539276220274_29573.01043.0Topological domainLumenal
TgeneATP2A2chr7:23571407chr12:110729824ENST00000539276220314_75673.01043.0Topological domainCytoplasmic
TgeneATP2A2chr7:23571407chr12:110729824ENST0000053927622070_8973.01043.0Topological domainLumenal
TgeneATP2A2chr7:23571407chr12:110729824ENST00000539276220777_78673.01043.0Topological domainLumenal
TgeneATP2A2chr7:23571407chr12:110729824ENST00000539276220808_82773.01043.0Topological domainCytoplasmic
TgeneATP2A2chr7:23571407chr12:110729824ENST00000539276220851_89673.01043.0Topological domainLumenal
TgeneATP2A2chr7:23571407chr12:110729824ENST00000539276220917_92973.01043.0Topological domainCytoplasmic
TgeneATP2A2chr7:23571407chr12:110729824ENST00000539276220949_96373.01043.0Topological domainLumenal
TgeneATP2A2chr7:23571407chr12:110729824ENST00000539276220985_104273.01043.0Topological domainCytoplasmic
TgeneATP2A2chr7:23571407chr12:110729824ENST00000308664221254_27373.0998.0TransmembraneHelical%3B Name%3D3
TgeneATP2A2chr7:23571407chr12:110729824ENST00000308664221296_31373.0998.0TransmembraneHelical%3B Name%3D4
TgeneATP2A2chr7:23571407chr12:110729824ENST00000308664221757_77673.0998.0TransmembraneHelical%3B Name%3D5
TgeneATP2A2chr7:23571407chr12:110729824ENST00000308664221828_85073.0998.0TransmembraneHelical%3B Name%3D7
TgeneATP2A2chr7:23571407chr12:110729824ENST00000308664221897_91673.0998.0TransmembraneHelical%3B Name%3D8
TgeneATP2A2chr7:23571407chr12:110729824ENST0000030866422190_11073.0998.0TransmembraneHelical%3B Name%3D2
TgeneATP2A2chr7:23571407chr12:110729824ENST00000308664221930_94873.0998.0TransmembraneHelical%3B Name%3D9
TgeneATP2A2chr7:23571407chr12:110729824ENST00000308664221964_98473.0998.0TransmembraneHelical%3B Name%3D10
TgeneATP2A2chr7:23571407chr12:110729824ENST00000395494219254_27373.01016.0TransmembraneHelical%3B Name%3D3
TgeneATP2A2chr7:23571407chr12:110729824ENST00000395494219296_31373.01016.0TransmembraneHelical%3B Name%3D4
TgeneATP2A2chr7:23571407chr12:110729824ENST00000395494219757_77673.01016.0TransmembraneHelical%3B Name%3D5
TgeneATP2A2chr7:23571407chr12:110729824ENST00000395494219828_85073.01016.0TransmembraneHelical%3B Name%3D7
TgeneATP2A2chr7:23571407chr12:110729824ENST00000395494219897_91673.01016.0TransmembraneHelical%3B Name%3D8
TgeneATP2A2chr7:23571407chr12:110729824ENST0000039549421990_11073.01016.0TransmembraneHelical%3B Name%3D2
TgeneATP2A2chr7:23571407chr12:110729824ENST00000395494219930_94873.01016.0TransmembraneHelical%3B Name%3D9
TgeneATP2A2chr7:23571407chr12:110729824ENST00000395494219964_98473.01016.0TransmembraneHelical%3B Name%3D10
TgeneATP2A2chr7:23571407chr12:110729824ENST00000539276220254_27373.01043.0TransmembraneHelical%3B Name%3D3
TgeneATP2A2chr7:23571407chr12:110729824ENST00000539276220296_31373.01043.0TransmembraneHelical%3B Name%3D4
TgeneATP2A2chr7:23571407chr12:110729824ENST00000539276220757_77673.01043.0TransmembraneHelical%3B Name%3D5
TgeneATP2A2chr7:23571407chr12:110729824ENST00000539276220828_85073.01043.0TransmembraneHelical%3B Name%3D7
TgeneATP2A2chr7:23571407chr12:110729824ENST00000539276220897_91673.01043.0TransmembraneHelical%3B Name%3D8
TgeneATP2A2chr7:23571407chr12:110729824ENST0000053927622090_11073.01043.0TransmembraneHelical%3B Name%3D2
TgeneATP2A2chr7:23571407chr12:110729824ENST00000539276220930_94873.01043.0TransmembraneHelical%3B Name%3D9
TgeneATP2A2chr7:23571407chr12:110729824ENST00000539276220964_98473.01043.0TransmembraneHelical%3B Name%3D10

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRA2Achr7:23571407chr12:110729824ENST00000297071-18226_28212.0283.0Compositional biasNote=Arg/Ser-rich (RS2 domain)
HgeneTRA2Achr7:23571407chr12:110729824ENST00000297071-1830_11212.0283.0Compositional biasNote=Arg/Ser-rich (RS1 domain)
HgeneTRA2Achr7:23571407chr12:110729824ENST00000297071-18119_19712.0283.0DomainRRM
HgeneTRA2Achr7:23571407chr12:110729824ENST00000297071-18198_22512.0283.0RegionNote=Linker
TgeneATP2A2chr7:23571407chr12:110729824ENST000003086642211_4873.0998.0Topological domainCytoplasmic
TgeneATP2A2chr7:23571407chr12:110729824ENST000003954942191_4873.01016.0Topological domainCytoplasmic
TgeneATP2A2chr7:23571407chr12:110729824ENST000005392762201_4873.01043.0Topological domainCytoplasmic
TgeneATP2A2chr7:23571407chr12:110729824ENST0000030866422149_6973.0998.0TransmembraneHelical%3B Name%3D1
TgeneATP2A2chr7:23571407chr12:110729824ENST0000039549421949_6973.01016.0TransmembraneHelical%3B Name%3D1
TgeneATP2A2chr7:23571407chr12:110729824ENST0000053927622049_6973.01043.0TransmembraneHelical%3B Name%3D1


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Fusion Gene Sequence for TRA2A-ATP2A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000297071_ENST00000308664_TCGA-L5-A43M_TRA2A_chr7_23571407_-_ATP2A2_chr12_110729824_length(transcript)=3813nt_BP=253nt
GCCCGCCCCCTTTACGTCGTGCTCTGAGGAGGCCAGGAGATTTCTGGCGGCGCCGGCGCCATTTTGCTGGAGCCTGCGACCGAGTGGGAG
TGGAGTGGAGCGGCTGTGGTTGCCGACTCTTTCCTCTTCCCCACGGTCCAGTCAGCGGGTTAATTAGGCCATCGGCCCTCGAGCCGAGAC
TTGTCTCTTATTTAGTTCTGGGGAGCGCCTCGTCGACATGAGTGATGTGGAGGAAAACAACTTCGAGGGCAGAGTTTTGGCTTGGTTTGA
AGAAGGTGAAGAAACAATTACAGCCTTTGTAGAACCTTTTGTAATTTTACTCATATTAGTAGCCAATGCAATTGTGGGTGTATGGCAGGA
AAGAAATGCTGAAAATGCCATCGAAGCCCTTAAGGAATATGAGCCTGAAATGGGCAAAGTGTATCGACAGGACAGAAAGAGTGTGCAGCG
GATTAAAGCTAAAGACATAGTTCCTGGTGATATTGTAGAAATTGCTGTTGGTGACAAAGTTCCTGCTGATATAAGGTTAACTTCCATCAA
ATCTACCACACTAAGAGTTGACCAGTCAATTCTCACAGGTGAATCTGTCTCTGTCATCAAGCACACTGATCCCGTCCCTGACCCACGAGC
TGTCAACCAAGATAAAAAGAACATGCTGTTTTCTGGTACAAACATTGCTGCTGGGAAAGCTATGGGAGTGGTGGTAGCAACTGGAGTTAA
CACCGAAATTGGCAAGATCCGGGATGAAATGGTGGCAACAGAACAGGAGAGAACACCCCTTCAGCAAAAACTAGATGAATTTGGGGAACA
GCTTTCCAAAGTCATCTCCCTTATTTGCATTGCAGTCTGGATCATAAATATTGGGCACTTCAATGACCCGGTTCATGGAGGGTCCTGGAT
CAGAGGTGCTATTTACTACTTTAAAATTGCAGTGGCCCTGGCTGTAGCAGCCATTCCTGAAGGTCTGCCTGCAGTCATCACCACCTGCCT
GGCTCTTGGAACTCGCAGAATGGCAAAGAAAAATGCCATTGTTCGAAGCCTCCCGTCTGTGGAAACCCTTGGTTGTACTTCTGTTATCTG
CTCAGACAAGACTGGTACACTTACAACAAACCAGATGTCAGTCTGCAGGATGTTCATTCTGGACAGAGTGGAAGGTGATACTTGTTCCCT
TAATGAGTTTACCATAACTGGATCAACTTATGCACCTATTGGAGAAGTGCATAAAGATGATAAACCAGTGAATTGTCACCAGTATGATGG
TCTGGTAGAATTAGCAACAATTTGTGCTCTTTGTAATGACTCTGCTTTGGATTACAATGAGGCAAAGGGTGTGTATGAAAAAGTTGGAGA
AGCTACAGAGACTGCTCTCACTTGCCTAGTAGAGAAGATGAATGTATTTGATACCGAATTGAAGGGTCTTTCTAAAATAGAACGTGCAAA
TGCCTGCAACTCAGTCATTAAACAGCTGATGAAAAAGGAATTCACTCTAGAGTTTTCACGTGACAGAAAGTCAATGTCGGTTTACTGTAC
ACCAAATAAACCAAGCAGGACATCAATGAGCAAGATGTTTGTGAAGGGTGCTCCTGAAGGTGTCATTGACAGGTGCACCCACATTCGAGT
TGGAAGTACTAAGGTTCCTATGACCTCTGGAGTCAAACAGAAGATCATGTCTGTCATTCGAGAGTGGGGTAGTGGCAGCGACACACTGCG
ATGCCTGGCCCTGGCCACTCATGACAACCCACTGAGAAGAGAAGAAATGCACCTTGAGGACTCTGCCAACTTTATTAAATATGAGACCAA
TCTGACCTTCGTTGGCTGCGTGGGCATGCTGGATCCTCCGAGAATCGAGGTGGCCTCCTCCGTGAAGCTGTGCCGGCAAGCAGGCATCCG
GGTCATCATGATCACTGGGGACAACAAGGGCACTGCTGTGGCCATCTGTCGCCGCATCGGCATCTTCGGGCAGGATGAGGACGTGACGTC
AAAAGCTTTCACAGGCCGGGAGTTTGATGAACTCAACCCCTCCGCCCAGCGAGACGCCTGCCTGAACGCCCGCTGTTTTGCTCGAGTTGA
ACCCTCCCACAAGTCTAAAATCGTAGAATTTCTTCAGTCTTTTGATGAGATTACAGCTATGACTGGCGATGGCGTGAACGATGCTCCTGC
TCTGAAGAAAGCCGAGATTGGCATTGCTATGGGCTCTGGCACTGCGGTGGCTAAAACCGCCTCTGAGATGGTCCTGGCGGATGACAACTT
CTCCACCATTGTGGCTGCCGTTGAGGAGGGGCGGGCAATCTACAACAACATGAAACAGTTCATCCGCTACCTCATCTCGTCCAACGTCGG
GGAAGTTGTCTGTATTTTCCTGACAGCAGCCCTTGGATTTCCCGAGGCTTTGATTCCTGTTCAGCTGCTCTGGGTCAATCTGGTGACAGA
TGGCCTGCCTGCCACTGCACTGGGGTTCAACCCTCCTGATCTGGACATCATGAATAAACCTCCCCGGAACCCAAAGGAACCATTGATCAG
CGGGTGGCTCTTTTTCCGTTACTTGGCTATTGGCTGTTACGTCGGCGCTGCTACCGTGGGTGCTGCTGCATGGTGGTTCATTGCTGCTGA
CGGTGGTCCAAGAGTGTCCTTCTACCAGCTGAGTCATTTCCTACAGTGTAAAGAGGACAACCCGGACTTTGAAGGCGTGGATTGTGCAAT
CTTTGAATCCCCATACCCGATGACAATGGCGCTCTCTGTTCTAGTAACTATAGAAATGTGTAACGCCCTCAACAGCTTGTCCGAAAACCA
GTCCTTGCTGAGGATGCCCCCCTGGGAGAACATCTGGCTCGTGGGCTCCATCTGCCTGTCCATGTCACTCCACTTCCTGATCCTCTATGT
CGAACCCTTGCCACTCATCTTCCAGATCACACCGCTGAACGTGACCCAGTGGCTGATGGTGCTGAAAATCTCCTTGCCCGTGATTCTCAT
GGATGAGACGCTCAAGTTTGTGGCCCGCAACTACCTGGAACCTGCAATACTGGAGTAACCGCTTCCTAAACCATTTTGCAGAAATGTAAG
GGTGTTCGGTTGCGTGCATGTGCGTTTTTAGCAACACATCTACCAACCCTGTGCATGACTGATGTTGGGGAAAAAGAAAAGTAAAAAACT
TCCCAACTCACTTTGTGTTATGTGGAGGAAATGTGTATTACCAATGGGGTTGTTAGCTTTTAAATCAAAATACTGATTACAGATGTACAA
TTTAGCTTAATCAGAAAGCCTCTCCAGAGAAGTTTGGTTTCTTTGCTGCAAGAGGAATGAGGCTCTGTAACCTTATCTAAGAACTTGGAA
GCCGTCAGCCAAGTCGCCACATTTCTCTGCAAAATGTCATAGCTTATATAAATGTACAGTATTCAATTGTAATGCATGCCTTCGGTTGTA
AGTAGCCAGATCCCTCTCCAGTGACATTGGAACATGCTACTTTTTAATTGGCCCTGTACAGTTTGCTTATTTATAAATTCATTAAAAACA
CTACAGGTGTTGAATGGTTAAAATGTAGGCCTCCAGTTCATTTTCAGTTATTTTCTGAGTGTGCAGACAGCTATTTCGCACTGTATTAAA
TGTAACTTATTTAATGAAATCAGAAGCAGTAGACAGATGTTGGTGCAATACAAATATTGTGATGCATTTATCTTAATAAAATGCTAAATG
TCAATTTATCACTGCGCATGTTTGACTTTAGACTGTAAATAGAGATCAGTTTGTTTCTTTCTGTGCTGGTAACAATGAGCGTCGCACAGA

>In-frame_ENST00000297071_ENST00000308664_TCGA-L5-A43M_TRA2A_chr7_23571407_-_ATP2A2_chr12_110729824_length(amino acids)=936AA_start in transcript=217_stop in transcript=3027
MSDVEENNFEGRVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIV
EIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVA
TEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNA
IVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCN
DSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKM
FVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDP
PRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQ
SFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALG
FPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSH
FLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPL

--------------------------------------------------------------
>In-frame_ENST00000297071_ENST00000395494_TCGA-L5-A43M_TRA2A_chr7_23571407_-_ATP2A2_chr12_110729824_length(transcript)=7700nt_BP=253nt
GCCCGCCCCCTTTACGTCGTGCTCTGAGGAGGCCAGGAGATTTCTGGCGGCGCCGGCGCCATTTTGCTGGAGCCTGCGACCGAGTGGGAG
TGGAGTGGAGCGGCTGTGGTTGCCGACTCTTTCCTCTTCCCCACGGTCCAGTCAGCGGGTTAATTAGGCCATCGGCCCTCGAGCCGAGAC
TTGTCTCTTATTTAGTTCTGGGGAGCGCCTCGTCGACATGAGTGATGTGGAGGAAAACAACTTCGAGGGCAGAGTTTTGGCTTGGTTTGA
AGAAGGTGAAGAAACAATTACAGCCTTTGTAGAACCTTTTGTAATTTTACTCATATTAGTAGCCAATGCAATTGTGGGTGTATGGCAGGA
AAGAAATGCTGAAAATGCCATCGAAGCCCTTAAGGAATATGAGCCTGAAATGGGCAAAGTGTATCGACAGGACAGAAAGAGTGTGCAGCG
GATTAAAGCTAAAGACATAGTTCCTGGTGATATTGTAGAAATTGCTGGTGAATCTGTCTCTGTCATCAAGCACACTGATCCCGTCCCTGA
CCCACGAGCTGTCAACCAAGATAAAAAGAACATGCTGTTTTCTGGTACAAACATTGCTGCTGGGAAAGCTATGGGAGTGGTGGTAGCAAC
TGGAGTTAACACCGAAATTGGCAAGATCCGGGATGAAATGGTGGCAACAGAACAGGAGAGAACACCCCTTCAGCAAAAACTAGATGAATT
TGGGGAACAGCTTTCCAAAGTCATCTCCCTTATTTGCATTGCAGTCTGGATCATAAATATTGGGCACTTCAATGACCCGGTTCATGGAGG
GTCCTGGATCAGAGGTGCTATTTACTACTTTAAAATTGCAGTGGCCCTGGCTGTAGCAGCCATTCCTGAAGGTCTGCCTGCAGTCATCAC
CACCTGCCTGGCTCTTGGAACTCGCAGAATGGCAAAGAAAAATGCCATTGTTCGAAGCCTCCCGTCTGTGGAAACCCTTGGTTGTACTTC
TGTTATCTGCTCAGACAAGACTGGTACACTTACAACAAACCAGATGTCAGTCTGCAGGATGTTCATTCTGGACAGAGTGGAAGGTGATAC
TTGTTCCCTTAATGAGTTTACCATAACTGGATCAACTTATGCACCTATTGGAGAAGTGCATAAAGATGATAAACCAGTGAATTGTCACCA
GTATGATGGTCTGGTAGAATTAGCAACAATTTGTGCTCTTTGTAATGACTCTGCTTTGGATTACAATGAGGCAAAGGGTGTGTATGAAAA
AGTTGGAGAAGCTACAGAGACTGCTCTCACTTGCCTAGTAGAGAAGATGAATGTATTTGATACCGAATTGAAGGGTCTTTCTAAAATAGA
ACGTGCAAATGCCTGCAACTCAGTCATTAAACAGCTGATGAAAAAGGAATTCACTCTAGAGTTTTCACGTGACAGAAAGTCAATGTCGGT
TTACTGTACACCAAATAAACCAAGCAGGACATCAATGAGCAAGATGTTTGTGAAGGGTGCTCCTGAAGGTGTCATTGACAGGTGCACCCA
CATTCGAGTTGGAAGTACTAAGGTTCCTATGACCTCTGGAGTCAAACAGAAGATCATGTCTGTCATTCGAGAGTGGGGTAGTGGCAGCGA
CACACTGCGATGCCTGGCCCTGGCCACTCATGACAACCCACTGAGAAGAGAAGAAATGCACCTTGAGGACTCTGCCAACTTTATTAAATA
TGAGACCAATCTGACCTTCGTTGGCTGCGTGGGCATGCTGGATCCTCCGAGAATCGAGGTGGCCTCCTCCGTGAAGCTGTGCCGGCAAGC
AGGCATCCGGGTCATCATGATCACTGGGGACAACAAGGGCACTGCTGTGGCCATCTGTCGCCGCATCGGCATCTTCGGGCAGGATGAGGA
CGTGACGTCAAAAGCTTTCACAGGCCGGGAGTTTGATGAACTCAACCCCTCCGCCCAGCGAGACGCCTGCCTGAACGCCCGCTGTTTTGC
TCGAGTTGAACCCTCCCACAAGTCTAAAATCGTAGAATTTCTTCAGTCTTTTGATGAGATTACAGCTATGACTGGCGATGGCGTGAACGA
TGCTCCTGCTCTGAAGAAAGCCGAGATTGGCATTGCTATGGGCTCTGGCACTGCGGTGGCTAAAACCGCCTCTGAGATGGTCCTGGCGGA
TGACAACTTCTCCACCATTGTGGCTGCCGTTGAGGAGGGGCGGGCAATCTACAACAACATGAAACAGTTCATCCGCTACCTCATCTCGTC
CAACGTCGGGGAAGTTGTCTGTATTTTCCTGACAGCAGCCCTTGGATTTCCCGAGGCTTTGATTCCTGTTCAGCTGCTCTGGGTCAATCT
GGTGACAGATGGCCTGCCTGCCACTGCACTGGGGTTCAACCCTCCTGATCTGGACATCATGAATAAACCTCCCCGGAACCCAAAGGAACC
ATTGATCAGCGGGTGGCTCTTTTTCCGTTACTTGGCTATTGGCTGTTACGTCGGCGCTGCTACCGTGGGTGCTGCTGCATGGTGGTTCAT
TGCTGCTGACGGTGGTCCAAGAGTGTCCTTCTACCAGCTGAGTCATTTCCTACAGTGTAAAGAGGACAACCCGGACTTTGAAGGCGTGGA
TTGTGCAATCTTTGAATCCCCATACCCGATGACAATGGCGCTCTCTGTTCTAGTAACTATAGAAATGTGTAACGCCCTCAACAGCTTGTC
CGAAAACCAGTCCTTGCTGAGGATGCCCCCCTGGGAGAACATCTGGCTCGTGGGCTCCATCTGCCTGTCCATGTCACTCCACTTCCTGAT
CCTCTATGTCGAACCCTTGCCACTCATCTTCCAGATCACACCGCTGAACGTGACCCAGTGGCTGATGGTGCTGAAAATCTCCTTGCCCGT
GATTCTCATGGATGAGACGCTCAAGTTTGTGGCCCGCAACTACCTGGAACCTGGTAAAGAGTGTGTGCAGCCTGCCACCAAATCCTGCTC
GTTCTCGGCATGCACCGATGGGATTTCCTGGCCGTTTGTGCTGCTCATAATGCCCCTGGTGATCTGGGTCTATAGCACAGACACTAACTT
TAGCGATATGTTCTGGTCTTGACTGACAGTTTTCCATAAAGAAGATGTTTAACTTAATCAATTAATTTTTTTATTGTTTAAAGCAACTGT
CTATTTCTGCTGAATTTTCACATGAACATACTGGCTGGTGATGGAGGTTTCATACTCTAGATTTTGTTTTGCTTTTTCTGACTCCAGTGG
GGCAAGATTTTCCTTTTTTATACACATAATTAAAGTGTCCATTGACATGTACAGAGAACTAACACTATTTTATGCAAATATTTTTTTGTA
GATGAAAAAGCATGTACAGTGTTCTGTTTAATACTCATCCTTGTATAAAAAAAATAGTTGAGCCAGCAGACATTGTCAGCAAATTAATTG
GCAGCAGATTTTAGGAAATGAATGTGTGTGGTTTTTTTTCTAAAACTAAATAGCATGTATTGTGTCTTTTGCATGATGATCCGGATTTAA
TTTGATATCACAGTCTAATTTTTATTCATAAGCCAATTTTTCTGCACTGAGCAGAGTCTTGCTACCTCAGTCAGTATTGTTTTGGTTTGC
TACTTCCCTCACCCACTTTGGCCTCCGTTCACCCCACCCCACCCCACCTCTCCCCACCTTACCCCCGCCCCGCTTGGCTTCTTCTTTAGG
ATTGTGATGGTTCGTTCTGTTTACATCAGTTTTAACGAGAGGTATGCCTGTACTCGCTTGTGCAGAAAACATTGTTCCAGATTCAATCGA
CTGGGTTTATGTCCCTTCACATAGTTTTTAAGGTTATTTATTTAAATGTCTAATGTATTTTATTGTAACAGACATTGTTTTGCCAACATT
GCCTATTTCAGTGGCACGTCATCTAGTTTTAAAAAAATAAAACATTTTAAATGGACAGAGAAAAATAACTGTCTTGTCTTTAACTCGTAA
GTGGCTTACCTGGGACTAACAGACATGTCCAACTTTCTCTCCAGTTCTTAGCTCAGAACTTTAGTTGTACTCTGCTTGAGGGGAAGAAGG
CTCCTGCTCTGCTGTGTAGGTAGTCATAGGAATTGTATTCTTAATGTACAGGCACTAATTGTCATCTGTGATGTACATTTTATGCAAGTT
TCTGCTGGCCTGGTATAGAGAACATAAGGGCAAGTGTGTATGTGTGTGTATGTGTGTGTTTTGTAAAATCTGTAAATAGCACATGACCAA
ATGAACATATTGTATAGAACTATTTTTATTTGAATGTGGCACTAACCACCACCACCGTTACTACGATCAATGTTTGCGCATGTTCGAGAT
GAGTCTCACCAACAGTGTGTAAGTCATTAACAGTCCTAACTGTGGTGTTTTCCTCCAATGCCTTCCAACATCCATCAACTAACGTGAGTA
TTTTCTTCCTGGGATTTGGATGCTTTAGCCTAAAGGTGACTGCCACCAAGTGAGATAACTGTATGTCACTAACTTATAAGCCGCCTCCAT
GGCAGATGCTGCTGTGCTCCCTGATGCCCTGTGAGCACCGGGGTTGCCTGTGGCGCCTGCCATGTGACTCGGGCGCAGCATCAGCTGGCT
GGAGGTGTGGCTTTCATAGACCTCCACAGGCTGCCTAGGACAAGATGACCAGGAGGGCCCAAGCCAGACAAAAGCCGGAGTGGGGAGAGA
GGCATTTCAGCCAGACCAACAGGCTGAAGGAGCTGTGCAGACTATTGCTAAAATGAGGGTTCGCAGCTGCCAGGAGTCATCCCAGAACAT
TGCTACTTATTTATTAAAAAGCTAAAAACTAGTGAAAGCAAGTAACTGAACCAGTGAACTCTGGGTATCGATAGGTTCGTCTTAAATAGG
CCACTTCCCCACTCCCCCACCCCCCCTTGCTTGGTCTTGTCCTTGGTGGCTAAGACTTAGCTCTGCAGGGGATGTTAAAGCACAGTTAGT
AGGACGTGGCTCTGCACAGCCCAAAAACCAGCTTACTCCTTAGCCAGGGTGTGAGGCCTCGACTATATTCTTCAAAATGTACTTAGGCTC
TGGTTACTGGGATGGCCAGTAGATGTAATGCAGATGGTTGGAGTTTGGGGAGGGTTAGGAGGCATCAAGCAGGACAAGGTGCTGCTGAGT
TCAGAGGGCCCACGTTCAAGGGATGGAGGTGGAACCTGGAGACCGACTCTTAAAAGCACAGTCCGTGGTTGGGTGTGGTGGCTCATGCCT
GTAAGTAAGTCTCAGCCCTTTGGAGGCCACAGCAGAAGGATTGCTTGAGCCCAGGTACTCAAACCAGCCTGGGCAACAGAGTGAGGCCCT
GTCAAAAAAAAATCAGCCTTACTGTGAAGCCTCCAAGGCTGCTCGCAGGCAGCTGTGGCTCTCGGGAAGGGAGGCTGCTTTGCCCAGCAG
GGAACATTTGGGGCAGGGGGTAAATTTTGCCAGTTTGAGCATCATGAGGTGTAACAAGAAATGGGTTGAATGGGCCAAATGCAAGGAGTG
CATCTCTGGGCTGCAAACTGACTTGAGTGCTGCACTATTGCTATTCCGTGCAAACAAAACTCAGCTTTTCCTGACTCAGTTCCTTGACTT
AGTGGCCTTTACAAAAAAAGTTGAGTAGTGTGTGGCCTGCTGTCGCACAGCCCCTAGTTAGCTTCATGGTTTCTCAGCTTCAGACCCCTC
CAGCCCACAGAGGAGCCCATGGAGGGACCCACTTCCCTTGGTCCAGACAGCTGGGAGTGGGTTAGGCCCACTGCTGTTTTGAGCAGGGCC
ACTTGCTCCATTTCACTGAAGGCTTTGCTGGGTGAAAACACTTCAGCATCTCCTCCTCAGGTCAACCCATAAAGACCAGGTCCAGCACCG
TGGTCTTGGCACATCCCTGGCCTCAGGCCCTCACCTAACAGTGAGGCAGCAGCTGCCCAGCCCCGCAATGTGCCTGCTGTCAGGCAGCTC
TTGCCTGAAACTTACTTCCACATTCTTTCCTGATGGGCAGGTGGCTGAAGGCCCAGCCATCAGTGTCGCTTGTTGCCACCCCGTGCCTCC
CTTGGCCTCTCTGAGCTTTGCCCAGAAGACCAACAATCATACATACCCTAACTGGGACACCACTCTGCAGAATGCAGATGATCCATTCTG
GAGGAAGCTGTCCCTTGAGCTCAGTGAGCTCCCAGGCAAGCAGGGCATCTGGCCGACTTCCCTCACAACAGCTGCTCCCACATCCCCTCG
GACTGGAGCTTCAGCCCTGACTGAGGTGGGCAGACCTAAGACCTGAGACCACAAGATTAGCTCAGTGTCTACCAAGCATCTAGCCACTGT
CCAGGGCCAGAGCATACCACGTCTGCAGTGCCTGTGAGCAGAGCCAGCAGTTGCCCTGTGACTGTAACCACCAAATTGTCCAAACACCCG
CTGCAGTTAGCAAGAAGGGTAGGCTTCACCCTCCTTTACTGAGGAGAATGATGCGGAGGAGTTTCCTCTCCAGGGCTAGGCAAGGCAGGC
GAGCAGCCAGAAGCCGGGTGCCCACAGGGCAGGGACAGGAAGGCTGTGCTGCTACTGGCTGCTCACTTCTCCATCAACCTCACCCTCTGC
ACCACTAACCAAGACCTTGTCCTCTTGCCTGTCTCGCTGCTTTCACAGCTGCAACGATTGTGTCTGCCTCATGGGGTTTTCCTCCAGAGC
CTTTATTCTGTAGCCAGACGACACGAGGAGTCTGTGTCACTGAGCCAGTGCTTCTAGATGCTACCCTGTGTGGGCGGCACCTCAGGGACA
GTAAATCAGAAATGCTGGTCTTGAAACCTTGAAAAGATCAAGCTGAATGTTCCTTTTCATCTGTCGCTGTTGATCTTCATCTATTTAAAT
AGGTATTCTAACGTTTCCTCTCTGTATTTCATGAAGCTGATTTCCTCTCTCTTTCCTTTTCAGCAATACTGGAGTAACCGCTTCCTAAAC
CATTTTGCAGAAATGTAAGGGTGTTCGGTTGCGTGCATGTGCGTTTTTAGCAACACATCTACCAACCCTGTGCATGACTGATGTTGGGGA
AAAAGAAAAGTAAAAAACTTCCCAACTCACTTTGTGTTATGTGGAGGAAATGTGTATTACCAATGGGGTTGTTAGCTTTTAAATCAAAAT
ACTGATTACAGATGTACAATTTAGCTTAATCAGAAAGCCTCTCCAGAGAAGTTTGGTTTCTTTGCTGCAAGAGGAATGAGGCTCTGTAAC
CTTATCTAAGAACTTGGAAGCCGTCAGCCAAGTCGCCACATTTCTCTGCAAAATGTCATAGCTTATATAAATGTACAGTATTCAATTGTA
ATGCATGCCTTCGGTTGTAAGTAGCCAGATCCCTCTCCAGTGACATTGGAACATGCTACTTTTTAATTGGCCCTGTACAGTTTGCTTATT
TATAAATTCATTAAAAACACTACAGGTGTTGAATGGTTAAAATGTAGGCCTCCAGTTCATTTTCAGTTATTTTCTGAGTGTGCAGACAGC
TATTTCGCACTGTATTAAATGTAACTTATTTAATGAAATCAGAAGCAGTAGACAGATGTTGGTGCAATACAAATATTGTGATGCATTTAT
CTTAATAAAATGCTAAATGTCAATTTATCACTGCGCATGTTTGACTTTAGACTGTAAATAGAGATCAGTTTGTTTCTTTCTGTGCTGGTA

>In-frame_ENST00000297071_ENST00000395494_TCGA-L5-A43M_TRA2A_chr7_23571407_-_ATP2A2_chr12_110729824_length(amino acids)=954AA_start in transcript=217_stop in transcript=3081
MSDVEENNFEGRVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIV
EIAGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLIC
IAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTT
NQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCL
VEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTS
GVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNK
GTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIA
MGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGF
NPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTM
ALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKISLPVILMDETLKFVAR

--------------------------------------------------------------
>In-frame_ENST00000297071_ENST00000539276_TCGA-L5-A43M_TRA2A_chr7_23571407_-_ATP2A2_chr12_110729824_length(transcript)=4019nt_BP=253nt
GCCCGCCCCCTTTACGTCGTGCTCTGAGGAGGCCAGGAGATTTCTGGCGGCGCCGGCGCCATTTTGCTGGAGCCTGCGACCGAGTGGGAG
TGGAGTGGAGCGGCTGTGGTTGCCGACTCTTTCCTCTTCCCCACGGTCCAGTCAGCGGGTTAATTAGGCCATCGGCCCTCGAGCCGAGAC
TTGTCTCTTATTTAGTTCTGGGGAGCGCCTCGTCGACATGAGTGATGTGGAGGAAAACAACTTCGAGGGCAGAGTTTTGGCTTGGTTTGA
AGAAGGTGAAGAAACAATTACAGCCTTTGTAGAACCTTTTGTAATTTTACTCATATTAGTAGCCAATGCAATTGTGGGTGTATGGCAGGA
AAGAAATGCTGAAAATGCCATCGAAGCCCTTAAGGAATATGAGCCTGAAATGGGCAAAGTGTATCGACAGGACAGAAAGAGTGTGCAGCG
GATTAAAGCTAAAGACATAGTTCCTGGTGATATTGTAGAAATTGCTGTTGGTGACAAAGTTCCTGCTGATATAAGGTTAACTTCCATCAA
ATCTACCACACTAAGAGTTGACCAGTCAATTCTCACAGGTGAATCTGTCTCTGTCATCAAGCACACTGATCCCGTCCCTGACCCACGAGC
TGTCAACCAAGATAAAAAGAACATGCTGTTTTCTGGTACAAACATTGCTGCTGGGAAAGCTATGGGAGTGGTGGTAGCAACTGGAGTTAA
CACCGAAATTGGCAAGATCCGGGATGAAATGGTGGCAACAGAACAGGAGAGAACACCCCTTCAGCAAAAACTAGATGAATTTGGGGAACA
GCTTTCCAAAGTCATCTCCCTTATTTGCATTGCAGTCTGGATCATAAATATTGGGCACTTCAATGACCCGGTTCATGGAGGGTCCTGGAT
CAGAGGTGCTATTTACTACTTTAAAATTGCAGTGGCCCTGGCTGTAGCAGCCATTCCTGAAGGTCTGCCTGCAGTCATCACCACCTGCCT
GGCTCTTGGAACTCGCAGAATGGCAAAGAAAAATGCCATTGTTCGAAGCCTCCCGTCTGTGGAAACCCTTGGTTGTACTTCTGTTATCTG
CTCAGACAAGACTGGTACACTTACAACAAACCAGATGTCAGTCTGCAGGATGTTCATTCTGGACAGAGTGGAAGGTGATACTTGTTCCCT
TAATGAGTTTACCATAACTGGATCAACTTATGCACCTATTGGAGAAGTGCATAAAGATGATAAACCAGTGAATTGTCACCAGTATGATGG
TCTGGTAGAATTAGCAACAATTTGTGCTCTTTGTAATGACTCTGCTTTGGATTACAATGAGGCAAAGGGTGTGTATGAAAAAGTTGGAGA
AGCTACAGAGACTGCTCTCACTTGCCTAGTAGAGAAGATGAATGTATTTGATACCGAATTGAAGGGTCTTTCTAAAATAGAACGTGCAAA
TGCCTGCAACTCAGTCATTAAACAGCTGATGAAAAAGGAATTCACTCTAGAGTTTTCACGTGACAGAAAGTCAATGTCGGTTTACTGTAC
ACCAAATAAACCAAGCAGGACATCAATGAGCAAGATGTTTGTGAAGGGTGCTCCTGAAGGTGTCATTGACAGGTGCACCCACATTCGAGT
TGGAAGTACTAAGGTTCCTATGACCTCTGGAGTCAAACAGAAGATCATGTCTGTCATTCGAGAGTGGGGTAGTGGCAGCGACACACTGCG
ATGCCTGGCCCTGGCCACTCATGACAACCCACTGAGAAGAGAAGAAATGCACCTTGAGGACTCTGCCAACTTTATTAAATATGAGACCAA
TCTGACCTTCGTTGGCTGCGTGGGCATGCTGGATCCTCCGAGAATCGAGGTGGCCTCCTCCGTGAAGCTGTGCCGGCAAGCAGGCATCCG
GGTCATCATGATCACTGGGGACAACAAGGGCACTGCTGTGGCCATCTGTCGCCGCATCGGCATCTTCGGGCAGGATGAGGACGTGACGTC
AAAAGCTTTCACAGGCCGGGAGTTTGATGAACTCAACCCCTCCGCCCAGCGAGACGCCTGCCTGAACGCCCGCTGTTTTGCTCGAGTTGA
ACCCTCCCACAAGTCTAAAATCGTAGAATTTCTTCAGTCTTTTGATGAGATTACAGCTATGACTGGCGATGGCGTGAACGATGCTCCTGC
TCTGAAGAAAGCCGAGATTGGCATTGCTATGGGCTCTGGCACTGCGGTGGCTAAAACCGCCTCTGAGATGGTCCTGGCGGATGACAACTT
CTCCACCATTGTGGCTGCCGTTGAGGAGGGGCGGGCAATCTACAACAACATGAAACAGTTCATCCGCTACCTCATCTCGTCCAACGTCGG
GGAAGTTGTCTGTATTTTCCTGACAGCAGCCCTTGGATTTCCCGAGGCTTTGATTCCTGTTCAGCTGCTCTGGGTCAATCTGGTGACAGA
TGGCCTGCCTGCCACTGCACTGGGGTTCAACCCTCCTGATCTGGACATCATGAATAAACCTCCCCGGAACCCAAAGGAACCATTGATCAG
CGGGTGGCTCTTTTTCCGTTACTTGGCTATTGGCTGTTACGTCGGCGCTGCTACCGTGGGTGCTGCTGCATGGTGGTTCATTGCTGCTGA
CGGTGGTCCAAGAGTGTCCTTCTACCAGCTGAGTCATTTCCTACAGTGTAAAGAGGACAACCCGGACTTTGAAGGCGTGGATTGTGCAAT
CTTTGAATCCCCATACCCGATGACAATGGCGCTCTCTGTTCTAGTAACTATAGAAATGTGTAACGCCCTCAACAGCTTGTCCGAAAACCA
GTCCTTGCTGAGGATGCCCCCCTGGGAGAACATCTGGCTCGTGGGCTCCATCTGCCTGTCCATGTCACTCCACTTCCTGATCCTCTATGT
CGAACCCTTGCCACTCATCTTCCAGATCACACCGCTGAACGTGACCCAGTGGCTGATGGTGCTGAAAATCTCCTTGCCCGTGATTCTCAT
GGATGAGACGCTCAAGTTTGTGGCCCGCAACTACCTGGAACCTGGTAAAGAGTGTGTGCAGCCTGCCACCAAATCCTGCTCGTTCTCGGC
ATGCACCGATGGGATTTCCTGGCCGTTTGTGCTGCTCATAATGCCCCTGGTGATCTGGGTCTATAGCACAGACACTAACTTTAGCGATAT
GTTCTGGTCTTGACTGACAGTTTTCCATAAAGAAGATGTTTAACTTAATCAATTAATTTTTTTATTGTTTAAAGCAACTGTCTATTTCTG
CTGAATTTTCACATGAACATACTGGCTGGTGATGGAGGTTTCATACTCTAGATTTTGTTTTGCTTTTTCTGACTCCAGTGGGGCAAGATT
TTCCTTTTTTATACACATAATTAAAGTGTCCATTGACATGTACAGAGAACTAACACTATTTTATGCAAATATTTTTTTGTAGATGAAAAA
GCATGTACAGTGTTCTGTTTAATACTCATCCTTGTATAAAAAAAATAGTTGAGCCAGCAGACATTGTCAGCAAATTAATTGGCAGCAGAT
TTTAGGAAATGAATGTGTGTGGTTTTTTTTCTAAAACTAAATAGCATGTATTGTGTCTTTTGCATGATGATCCGGATTTAATTTGATATC
ACAGTCTAATTTTTATTCATAAGCCAATTTTTCTGCACTGAGCAGAGTCTTGCTACCTCAGTCAGTATTGTTTTGGTTTGCTACTTCCCT
CACCCACTTTGGCCTCCGTTCACCCCACCCCACCCCACCTCTCCCCACCTTACCCCCGCCCCGCTTGGCTTCTTCTTTAGGATTGTGATG
GTTCGTTCTGTTTACATCAGTTTTAACGAGAGGTATGCCTGTACTCGCTTGTGCAGAAAACATTGTTCCAGATTCAATCGACTGGGTTTA
TGTCCCTTCACATAGTTTTTAAGGTTATTTATTTAAATGTCTAATGTATTTTATTGTAACAGACATTGTTTTGCCAACATTGCCTATTTC

>In-frame_ENST00000297071_ENST00000539276_TCGA-L5-A43M_TRA2A_chr7_23571407_-_ATP2A2_chr12_110729824_length(amino acids)=981AA_start in transcript=217_stop in transcript=3162
MSDVEENNFEGRVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIV
EIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVA
TEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNA
IVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCN
DSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKM
FVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDP
PRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQ
SFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALG
FPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSH
FLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TRA2A-ATP2A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneATP2A2chr7:23571407chr12:110729824ENST00000308664221575_59473.0998.0HAX1
TgeneATP2A2chr7:23571407chr12:110729824ENST00000395494219575_59473.01016.0HAX1
TgeneATP2A2chr7:23571407chr12:110729824ENST00000539276220575_59473.01043.0HAX1
TgeneATP2A2chr7:23571407chr12:110729824ENST00000308664221787_80773.0998.0PLN
TgeneATP2A2chr7:23571407chr12:110729824ENST00000308664221931_94273.0998.0PLN
TgeneATP2A2chr7:23571407chr12:110729824ENST00000395494219787_80773.01016.0PLN
TgeneATP2A2chr7:23571407chr12:110729824ENST00000395494219931_94273.01016.0PLN
TgeneATP2A2chr7:23571407chr12:110729824ENST00000539276220787_80773.01043.0PLN
TgeneATP2A2chr7:23571407chr12:110729824ENST00000539276220931_94273.01043.0PLN
TgeneATP2A2chr7:23571407chr12:110729824ENST00000308664221788_104273.0998.0TMEM64 and PDIA3
TgeneATP2A2chr7:23571407chr12:110729824ENST00000395494219788_104273.01016.0TMEM64 and PDIA3
TgeneATP2A2chr7:23571407chr12:110729824ENST00000539276220788_104273.01043.0TMEM64 and PDIA3


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRA2A-ATP2A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRA2A-ATP2A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRA2AC0037274Dermatologic disorders1CTD_human
HgeneTRA2AC0274861Arsenic Poisoning, Inorganic1CTD_human
HgeneTRA2AC0274862Nervous System, Organic Arsenic Poisoning1CTD_human
HgeneTRA2AC0311375Arsenic Poisoning1CTD_human
HgeneTRA2AC0751851Arsenic Encephalopathy1CTD_human
HgeneTRA2AC0751852Arsenic Induced Polyneuropathy1CTD_human
TgeneATP2A2C0022595Keratosis Follicularis12CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneATP2A2C0265971Acrokeratosis Verruciformis of Hopf3CTD_human;ORPHANET;UNIPROT
TgeneATP2A2C0011570Mental Depression2PSYGENET
TgeneATP2A2C0011581Depressive disorder2PSYGENET
TgeneATP2A2C0473575Acantholytic Dyskeratotic Epidermal Nevus2CTD_human
TgeneATP2A2C0525045Mood Disorders2PSYGENET
TgeneATP2A2C0002152Alloxan Diabetes1CTD_human
TgeneATP2A2C0011853Diabetes Mellitus, Experimental1CTD_human
TgeneATP2A2C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneATP2A2C0018799Heart Diseases1CTD_human
TgeneATP2A2C0018800Cardiomegaly1CTD_human
TgeneATP2A2C0018801Heart failure1CTD_human
TgeneATP2A2C0018802Congestive heart failure1CTD_human;GENOMICS_ENGLAND
TgeneATP2A2C0023212Left-Sided Heart Failure1CTD_human
TgeneATP2A2C0027055Myocardial Reperfusion Injury1CTD_human
TgeneATP2A2C0036341Schizophrenia1PSYGENET
TgeneATP2A2C0038220Status Epilepticus1CTD_human
TgeneATP2A2C0038433Streptozotocin Diabetes1CTD_human
TgeneATP2A2C0206145Stunned Myocardium1CTD_human
TgeneATP2A2C0206146Myocardial Stunning1CTD_human
TgeneATP2A2C0235527Heart Failure, Right-Sided1CTD_human
TgeneATP2A2C0242698Ventricular Dysfunction, Left1CTD_human
TgeneATP2A2C0270823Petit mal status1CTD_human
TgeneATP2A2C0311335Grand Mal Status Epilepticus1CTD_human
TgeneATP2A2C0376416Hibernation, Myocardial1CTD_human
TgeneATP2A2C0393734Complex Partial Status Epilepticus1CTD_human
TgeneATP2A2C0751522Status Epilepticus, Subclinical1CTD_human
TgeneATP2A2C0751523Non-Convulsive Status Epilepticus1CTD_human
TgeneATP2A2C0751524Simple Partial Status Epilepticus1CTD_human
TgeneATP2A2C0853897Diabetic Cardiomyopathies1CTD_human
TgeneATP2A2C1383860Cardiac Hypertrophy1CTD_human
TgeneATP2A2C1959583Myocardial Failure1CTD_human
TgeneATP2A2C1961112Heart Decompensation1CTD_human