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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRIM2-WDR37 (FusionGDB2 ID:93366)

Fusion Gene Summary for TRIM2-WDR37

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM2-WDR37
Fusion gene ID: 93366
HgeneTgene
Gene symbol

TRIM2

WDR37

Gene ID

23321

22884

Gene nametripartite motif containing 2WD repeat domain 37
SynonymsCMT2R|RNF86NOCGUS
Cytomap

4q31.3

10p15.3

Type of geneprotein-codingprotein-coding
Descriptiontripartite motif-containing protein 2E3 ubiquitin-protein ligase TRIM2RING finger protein 86RING-type E3 ubiquitin transferase TRIM2tripartite motif protein TRIM2WD repeat-containing protein 37
Modification date2020031520200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000437508, ENST00000494872, 
ENST00000338700, 		ENST00000358220, 
ENST00000381329, ENST00000263150, 
ENST00000482165, 
Fusion gene scores* DoF score18 X 16 X 9=25928 X 6 X 5=240
# samples 248
** MAII scorelog2(24/2592*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIM2 [Title/Abstract] AND WDR37 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRIM2(154125712)-WDR37(1149542), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TRIM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across WDR37 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-E1-5304-01ATRIM2chr4

154125712

-WDR37chr10

1149542

+


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Fusion Gene ORF analysis for TRIM2-WDR37

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000437508ENST00000358220TRIM2chr4

154125712

-WDR37chr10

1149542

+
intron-intronENST00000437508ENST00000381329TRIM2chr4

154125712

-WDR37chr10

1149542

+
intron-intronENST00000437508ENST00000263150TRIM2chr4

154125712

-WDR37chr10

1149542

+
intron-intronENST00000437508ENST00000482165TRIM2chr4

154125712

-WDR37chr10

1149542

+
3UTR-3CDSENST00000494872ENST00000358220TRIM2chr4

154125712

-WDR37chr10

1149542

+
3UTR-intronENST00000494872ENST00000381329TRIM2chr4

154125712

-WDR37chr10

1149542

+
3UTR-intronENST00000494872ENST00000263150TRIM2chr4

154125712

-WDR37chr10

1149542

+
3UTR-intronENST00000494872ENST00000482165TRIM2chr4

154125712

-WDR37chr10

1149542

+
In-frameENST00000338700ENST00000358220TRIM2chr4

154125712

-WDR37chr10

1149542

+
5CDS-intronENST00000338700ENST00000381329TRIM2chr4

154125712

-WDR37chr10

1149542

+
5CDS-intronENST00000338700ENST00000263150TRIM2chr4

154125712

-WDR37chr10

1149542

+
5CDS-intronENST00000338700ENST00000482165TRIM2chr4

154125712

-WDR37chr10

1149542

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000338700TRIM2chr4154125712-ENST00000358220WDR37chr101149542+3807955853282

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000338700ENST00000358220TRIM2chr4154125712-WDR37chr101149542+0.0025331970.9974668

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Fusion Genomic Features for TRIM2-WDR37


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRIM2-WDR37


check button Go to

FGviewer for the breakpoints of chr4:154125712-chr10:1149542

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWDR37chr4:154125712chr10:1149542ENST00000263150814279_318242.0495.0RepeatNote=WD 3
TgeneWDR37chr4:154125712chr10:1149542ENST00000263150814321_360242.0495.0RepeatNote=WD 4
TgeneWDR37chr4:154125712chr10:1149542ENST00000263150814365_403242.0495.0RepeatNote=WD 5
TgeneWDR37chr4:154125712chr10:1149542ENST00000263150814406_445242.0495.0RepeatNote=WD 6
TgeneWDR37chr4:154125712chr10:1149542ENST00000263150814452_493242.0495.0RepeatNote=WD 7
TgeneWDR37chr4:154125712chr10:1149542ENST00000358220814279_318242.0495.0RepeatNote=WD 3
TgeneWDR37chr4:154125712chr10:1149542ENST00000358220814321_360242.0495.0RepeatNote=WD 4
TgeneWDR37chr4:154125712chr10:1149542ENST00000358220814365_403242.0495.0RepeatNote=WD 5
TgeneWDR37chr4:154125712chr10:1149542ENST00000358220814406_445242.0495.0RepeatNote=WD 6
TgeneWDR37chr4:154125712chr10:1149542ENST00000358220814452_493242.0495.0RepeatNote=WD 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM2chr4:154125712chr10:1149542ENST00000338700-112320_42110.0772.0RepeatNote=Filamin
HgeneTRIM2chr4:154125712chr10:1149542ENST00000338700-112473_51610.0772.0RepeatNote=NHL 1
HgeneTRIM2chr4:154125712chr10:1149542ENST00000338700-112520_56310.0772.0RepeatNote=NHL 2
HgeneTRIM2chr4:154125712chr10:1149542ENST00000338700-112564_60510.0772.0RepeatNote=NHL 3
HgeneTRIM2chr4:154125712chr10:1149542ENST00000338700-112609_65210.0772.0RepeatNote=NHL 4
HgeneTRIM2chr4:154125712chr10:1149542ENST00000338700-112656_69910.0772.0RepeatNote=NHL 5
HgeneTRIM2chr4:154125712chr10:1149542ENST00000338700-112700_74310.0772.0RepeatNote=NHL 6
HgeneTRIM2chr4:154125712chr10:1149542ENST00000437508-112320_4210745.0RepeatNote=Filamin
HgeneTRIM2chr4:154125712chr10:1149542ENST00000437508-112473_5160745.0RepeatNote=NHL 1
HgeneTRIM2chr4:154125712chr10:1149542ENST00000437508-112520_5630745.0RepeatNote=NHL 2
HgeneTRIM2chr4:154125712chr10:1149542ENST00000437508-112564_6050745.0RepeatNote=NHL 3
HgeneTRIM2chr4:154125712chr10:1149542ENST00000437508-112609_6520745.0RepeatNote=NHL 4
HgeneTRIM2chr4:154125712chr10:1149542ENST00000437508-112656_6990745.0RepeatNote=NHL 5
HgeneTRIM2chr4:154125712chr10:1149542ENST00000437508-112700_7430745.0RepeatNote=NHL 6
HgeneTRIM2chr4:154125712chr10:1149542ENST00000338700-112113_15410.0772.0Zinc fingerB box-type
HgeneTRIM2chr4:154125712chr10:1149542ENST00000338700-11223_6410.0772.0Zinc fingerRING-type
HgeneTRIM2chr4:154125712chr10:1149542ENST00000437508-112113_1540745.0Zinc fingerB box-type
HgeneTRIM2chr4:154125712chr10:1149542ENST00000437508-11223_640745.0Zinc fingerRING-type
TgeneWDR37chr4:154125712chr10:1149542ENST00000263150814154_194242.0495.0RepeatNote=WD 1
TgeneWDR37chr4:154125712chr10:1149542ENST00000263150814197_236242.0495.0RepeatNote=WD 2
TgeneWDR37chr4:154125712chr10:1149542ENST00000358220814154_194242.0495.0RepeatNote=WD 1
TgeneWDR37chr4:154125712chr10:1149542ENST00000358220814197_236242.0495.0RepeatNote=WD 2


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Fusion Gene Sequence for TRIM2-WDR37


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000338700_ENST00000358220_TCGA-E1-5304-01A_TRIM2_chr4_154125712_-_WDR37_chr10_1149542_length(transcript)=3807nt_BP=95nt
CCCAGTTGTCTGCGGGCTGCGGGGAGCTAAGTCCCCAGATTGGAGGAGGCTGGCTCTGGTCTTCGATGCACAGGAGTGGCCGTTATGGAA
CGCAGATATCTGGGGAAGATGAAGTAGAGTGCTCTGACAAGGACGAGCCCGACCTCGATGGGGATGTGTCCAGCGACTGCCCCACCATCC
GCGTCCCACTGACATCCCTCAAGAGCCACCAGGGCGTGGTCATCGCCTCCGACTGGCTGGTTGGGGGGAAGCAGGCTGTGACTGCCTCCT
GGGACCGGACGGCAAACCTGTACGACGTGGAGACGTCCGAGCTCGTTCACTCTCTGACAGGGCACGACCAGGAGTTGACGCACTGCTGCA
CACACCCCACCCAGCGGCTCGTGGTGACCTCCTCCCGTGACACGACTTTCCGCCTCTGGGATTTCAGGGACCCCTCCATCCACTCGGTGA
ATGTTTTCCAGGGACACACGGACACTGTGACTTCTGCCGTGTTCACCGTGGGAGACAACGTGGTTTCAGGCAGCGATGACCGCACGGTGA
AAGTCTGGGACTTGAAAAATATGAGATCCCCCATTGCAACTATTCGCACGGACTCTGCCATTAACAGGATCAATGTATGTGTCGGCCAAA
AAATCATAGCCCTCCCCCATGACAACCGACAAGTGAGACTGTTTGATATGTCAGGAGTGCGCCTGGCGCGGCTTCCCCGGAGCAGCCGAC
AGGGCCACAGGAGAATGGTATGCTGCTCGGCATGGAGTGAAGACCACCCCGTGTGCAATCTGTTCACCTGTGGGTTTGACCGGCAAGCCA
TTGGTTGGAACATCAACATCCCTGCATTGCTACAAGAAAAATAAGGACACCGGCAGCCCTTAGTTTCACTGTTTGCCAGCACAGACCTTT
GATGGGTGCAGGCTTTTCTGCGTATTAATCAGCCATTTTTGTGAGAGTTTGACCCTGGAAAGGGTGCTTTGTATATGTTCTTTTCACATA
GTGCCCAGCTTGCATGAAATGTACAGAGAAATGTGTGGTCGTATTTTTTACTTTTGTCTTGTATATGTATGTATATTGGGTCCTCTGGGC
AGTAGAGGCAAAGCTCACCTCCCATGTAGCACATGAAATGCTTGTGAGTTGTTGACATTGGACAGGTGAACAGTAGGGCATTACATTTGT
GTGAATTAAATGTGAACTTCTGTATTACGTTGCGGCGTCGGCAGTCCTGCGTTCCCTGGAGTAACTGTACGTATCTGCCTTTGCTGGGAA
GACTGTGGGGCTGCCTGTGTTGGCTGGCGACCAGCAGGATTGCTCCAGGATTTTGTGTTTACCTCGCGTGAAGTTCAGCACGTGCTGTCG
TGTAGTCAGCTTCTACTCTAATTTCTGTTACAGTTCTGCAAAGGTAACCTGGAGTTTAGAAGTTAAAAAAAAGCATGGGATGTTGGATTT
GCACCATTTGGAGTTTCTTTAGGAAAGAAAAGTTTTCTGCTTTTTTATAGAAAATCATTTCAGTCTCCCGAGGTCTCATGCTAGCAAATT
TTGAAATAGGATTCTAATCACTGATTTCAAATATTAAGCAAAATGTAAAGCACTTTAATTTATAGCTATGGTTATAAACAGGTTTTAGAT
GTTTCAAATGACTTGTCCACTGAATGTCACTTGACCTTGATAAGAGGCCGCCTGCACACAGAGCCCAGTTAATTCTCCGCACCTCGGTTG
TGTGCTTCCGAATGGGCTCACTCCCGTGGTGGTGTTTGAGAGCCAACAACACTACCTCAGAGACGGGTCTTTGGGAAACTTTGGGTCTCA
CTGTTGCCTGGCTGGAGCACTTTGGTTTATAGCTGGAATACTGAGTTCAGTTCAGAAGGCAGGAAAGACAGTCACACCGACGTGTCCTGA
AGGTGTAGGCTCTCCACTTAGGCGCACAAGCTGACGGCTGCAGCCAGCAGGCCCCGGTGACGAGACACTTCCAGGTCTTGTGGTGGGGAC
GCCTCTCAGTGCCAGTCCCGCCACTGCTGAGTGAGCCTGGTGTTCTTGCCTTCTTGGAAATTACTGCTCACCTGGTATCTGTACGTTAAT
GTTTCTTGCTGAGTTACAGTTTTGATAAAGAGGCTCTCATTTCCTGTGTCTTGTATATTCAGTCCTTTCAATACGTCCACCTGGAGGCTC
ACCACTTGGAGAGACACAGGAAGGTAATATTTACAGCTGTCATGTGACATCCCCAGGTCTTTGTGTTTTGCCCTGTTTTACGGTGAGGTA
GGAGGGAACCCATCTGGGGACCGGTAGGTGCAGGTGCAGTAGGACGTGGGACTTTTGGACCCGTCCTTTGGTGCAGCTCGCCAGGGATGA
GAGGCACCTCCCTACTTGGGTCTTCAGGAGCTGGTCCAAGGAGCTTCGAATCTAAGTCATCTAGAATGACCCTGAAATGACTGACAGCCC
CGGGCCCAAGAAAAACCCATAACCACCTCAGATGGATCTGACGTGGCTAAGGGACAAACAGCAAATATTTCAGTCATTTTGATTTTACAA
ATAAAAAATGTGTTGTGTTTTTGTCCGACATTATTTCCTGACTGCACTGTTCTGAGAATGGAGTCCACCTGGTCCCTCTGGTTGATTAGA
ATCTCAGGTTTCAGCTCCTGCTGTCCTGAGCGAACTTGCCTGATGCAGGGCTGTGCTGTGTCCAGATGTTGCTGGGGCCTCACTTTTTCT
CTTGGCTGGAGGTCCAATTGCCAGAGCCTCCCACACTGCACATACAAAGGTCTGAGCCCAGGGCAGCTTCTGGGGCCACTGCACAGGCCA
CCTGCTTGGGTTCCTCGGAGTTTAATTTGAAAGTCTGGGTGTCTTAGGATGATGGTTAGGAACATTGAAAAATGGCTGCAAATAGCCAAA
TCAAACTTAAGAACCAGATCTCTGCCAGATTAAACATTTTTGAAGCTTTTAAAAGTCAATATTCCTAGTGGCCACTGAGTTCCAGGCACA
CTGGTGCCCTTTACTGCCACAGCTGCTCACCTTGTCTGGCAAACTGGAGGGACCTCAGAAACTGGACTCCTGCATGTCCTTGGGGGCGCA
GCCCTGTGGTGCTCAGGCAGAGCTCTCAGGAGCCGGGGCACCTTGCTGTTCGCTGCTGTGTCGTCTTCTAATGTGAGCTCATCCACTGCT
GCTGCAGCGTGGTGATCAGGAGTCACAGACAAGATCGGGGATGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCACGTGTGTGTGGCTAAA
TTAAGTCATACTGTCAACCACACGTGATCTCGTCTGAAACAGTGTTTGGAAGTGGGAACAGTTTTGTCCTGTATGCTGATGTGTCCAGAA
TTTCATTTAATGATAGACGGAAAATGTGTGGTTACTGAAAACTGTATATGATACAGAATTTCATAAGAGCCATGCTGTTGGGCAAAGCAA
CTCTTTTTCAACCACTGCTCATCAGTTTCTGTAGAGACAAAAACTCTGTACATATTTTGGAATCTGAAGAATCCTATGTAAATCATTTGT
TACTTAAGTCTGTGAAAAACATATTTCTTTGGAGGAAAATGTATGCATTTATAAGTGTTCCATGGAATCAGTTTTTATTGTATCGATATA
ATTGTCTCTAAGTGTTGACTGTCTTCATTGCAATATGAAATTCATTAAAATGTCCATGTTCCATAATTACTATTATAAAAGCTTTGTGTT
ATTGGGAGTCTTATTATTTTTATAGTTTTTCATGTTTTGCTTTGGTGAAACATTGTGAATGACTATATAAACATCACGATGAGCTAGAAA

>In-frame_ENST00000338700_ENST00000358220_TCGA-E1-5304-01A_TRIM2_chr4_154125712_-_WDR37_chr10_1149542_length(amino acids)=282AA_start in transcript=5_stop in transcript=853
MSAGCGELSPQIGGGWLWSSMHRSGRYGTQISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWD
RTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKV
WDLKNMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARLPRSSRQGHRRMVCCSAWSEDHPVCNLFTCGFDRQAIG

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Fusion Gene PPI Analysis for TRIM2-WDR37


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRIM2-WDR37


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRIM2-WDR37


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIM2C3809655CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2R2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneTRIM2C0029408Degenerative polyarthritis1CTD_human
HgeneTRIM2C0086743Osteoarthrosis Deformans1CTD_human
TgeneWDR37C0009363Congenital ocular coloboma (disorder)1GENOMICS_ENGLAND
TgeneWDR37C0010038Corneal Opacity1GENOMICS_ENGLAND
TgeneWDR37C0036572Seizures1GENOMICS_ENGLAND
TgeneWDR37C0042063Urogenital Abnormalities1GENOMICS_ENGLAND
TgeneWDR37C0243050Cardiovascular Abnormalities1GENOMICS_ENGLAND
TgeneWDR37C0266544Microcornea1GENOMICS_ENGLAND
TgeneWDR37C0344559Irido-corneo-trabecular dysgenesis (disorder)1GENOMICS_ENGLAND
TgeneWDR37C0557874Global developmental delay1GENOMICS_ENGLAND
TgeneWDR37C2677504AUTISM, SUSCEPTIBILITY TO, 151GENOMICS_ENGLAND
TgeneWDR37C3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneWDR37C4021790Abnormality of the skeletal system1GENOMICS_ENGLAND
TgeneWDR37C4022810Abnormality of nervous system morphology1GENOMICS_ENGLAND
TgeneWDR37C4025860Hearing abnormality1GENOMICS_ENGLAND
TgeneWDR37C4316870Abnormality of the eye1GENOMICS_ENGLAND