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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRIM24-NTRK2 (FusionGDB2 ID:93375)

Fusion Gene Summary for TRIM24-NTRK2

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM24-NTRK2
Fusion gene ID: 93375
HgeneTgene
Gene symbol

TRIM24

NTRK2

Gene ID

8805

4915

Gene nametripartite motif containing 24neurotrophic receptor tyrosine kinase 2
SynonymsPTC6|RNF82|TF1A|TIF1|TIF1A|TIF1ALPHA|hTIF1EIEE58|GP145-TrkB|OBHD|TRKB|trk-B
Cytomap

7q33-q34

9q21.33

Type of geneprotein-codingprotein-coding
Descriptiontranscription intermediary factor 1-alphaE3 ubiquitin-protein ligase TRIM24RING finger protein 82RING-type E3 ubiquitin transferase TIF1-alphaTIF1-alphatranscriptional intermediary factor 1BDNF/NT-3 growth factors receptorBDNF-tropomyosine receptor kinase Bneurotrophic tyrosine kinase receptor type 2tropomyosin-related kinase Btyrosine kinase receptor B
Modification date2020031320200313
UniProtAcc.

Q16620

Ensembl transtripts involved in fusion geneENST00000343526, ENST00000415680, 
ENST00000497516, 		ENST00000376214, 
ENST00000376213, ENST00000395882, 
ENST00000304053, ENST00000376208, 
ENST00000277120, ENST00000323115, 
ENST00000359847, ENST00000395866, 
Fusion gene scores* DoF score10 X 9 X 7=63010 X 9 X 7=630
# samples 1010
** MAII scorelog2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIM24 [Title/Abstract] AND NTRK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRIM24(138258387)-NTRK2(87482158), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM24

GO:0016567

protein ubiquitination

19556538

HgeneTRIM24

GO:0071391

cellular response to estrogen stimulus

21164480


check buttonFusion gene breakpoints across TRIM24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NTRK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-8091-01ATRIM24chr7

138258387

+NTRK2chr9

87482158

+
ChimerDB4LUADTCGA-55-8091-01ATRIM24chr7

138258387

+NTRK2chr9

87482158

+
ChimerDB4LUADTCGA-55-8091-01ATRIM24chr7

138258387

-NTRK2chr9

87482158

+


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Fusion Gene ORF analysis for TRIM24-NTRK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000343526ENST00000376214TRIM24chr7

138258387

+NTRK2chr9

87482158

+
In-frameENST00000343526ENST00000376213TRIM24chr7

138258387

+NTRK2chr9

87482158

+
5CDS-intronENST00000343526ENST00000395882TRIM24chr7

138258387

+NTRK2chr9

87482158

+
5CDS-intronENST00000343526ENST00000304053TRIM24chr7

138258387

+NTRK2chr9

87482158

+
5CDS-intronENST00000343526ENST00000376208TRIM24chr7

138258387

+NTRK2chr9

87482158

+
5CDS-intronENST00000343526ENST00000277120TRIM24chr7

138258387

+NTRK2chr9

87482158

+
5CDS-intronENST00000343526ENST00000323115TRIM24chr7

138258387

+NTRK2chr9

87482158

+
5CDS-intronENST00000343526ENST00000359847TRIM24chr7

138258387

+NTRK2chr9

87482158

+
5CDS-intronENST00000343526ENST00000395866TRIM24chr7

138258387

+NTRK2chr9

87482158

+
In-frameENST00000415680ENST00000376214TRIM24chr7

138258387

+NTRK2chr9

87482158

+
In-frameENST00000415680ENST00000376213TRIM24chr7

138258387

+NTRK2chr9

87482158

+
5CDS-intronENST00000415680ENST00000395882TRIM24chr7

138258387

+NTRK2chr9

87482158

+
5CDS-intronENST00000415680ENST00000304053TRIM24chr7

138258387

+NTRK2chr9

87482158

+
5CDS-intronENST00000415680ENST00000376208TRIM24chr7

138258387

+NTRK2chr9

87482158

+
5CDS-intronENST00000415680ENST00000277120TRIM24chr7

138258387

+NTRK2chr9

87482158

+
5CDS-intronENST00000415680ENST00000323115TRIM24chr7

138258387

+NTRK2chr9

87482158

+
5CDS-intronENST00000415680ENST00000359847TRIM24chr7

138258387

+NTRK2chr9

87482158

+
5CDS-intronENST00000415680ENST00000395866TRIM24chr7

138258387

+NTRK2chr9

87482158

+
intron-3CDSENST00000497516ENST00000376214TRIM24chr7

138258387

+NTRK2chr9

87482158

+
intron-3CDSENST00000497516ENST00000376213TRIM24chr7

138258387

+NTRK2chr9

87482158

+
intron-intronENST00000497516ENST00000395882TRIM24chr7

138258387

+NTRK2chr9

87482158

+
intron-intronENST00000497516ENST00000304053TRIM24chr7

138258387

+NTRK2chr9

87482158

+
intron-intronENST00000497516ENST00000376208TRIM24chr7

138258387

+NTRK2chr9

87482158

+
intron-intronENST00000497516ENST00000277120TRIM24chr7

138258387

+NTRK2chr9

87482158

+
intron-intronENST00000497516ENST00000323115TRIM24chr7

138258387

+NTRK2chr9

87482158

+
intron-intronENST00000497516ENST00000359847TRIM24chr7

138258387

+NTRK2chr9

87482158

+
intron-intronENST00000497516ENST00000395866TRIM24chr7

138258387

+NTRK2chr9

87482158

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000343526TRIM24chr7138258387+ENST00000376214NTRK2chr987482158+545522299233011069
ENST00000343526TRIM24chr7138258387+ENST00000376213NTRK2chr987482158+545522299233011069
ENST00000415680TRIM24chr7138258387+ENST00000376214NTRK2chr987482158+525220261143098994
ENST00000415680TRIM24chr7138258387+ENST00000376213NTRK2chr987482158+525220261143098994

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000343526ENST00000376214TRIM24chr7138258387+NTRK2chr987482158+0.0010857980.99891424
ENST00000343526ENST00000376213TRIM24chr7138258387+NTRK2chr987482158+0.0010857980.99891424
ENST00000415680ENST00000376214TRIM24chr7138258387+NTRK2chr987482158+0.0006589530.9993411
ENST00000415680ENST00000376213TRIM24chr7138258387+NTRK2chr987482158+0.0006589530.9993411

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Fusion Genomic Features for TRIM24-NTRK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TRIM24chr7138258387+NTRK2chr987482157+0.0001508930.9998491
TRIM24chr7138258387+NTRK2chr987482157+0.0001508930.9998491

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRIM24-NTRK2


check button Go to

FGviewer for the breakpoints of chr7:138258387-chr9:87482158

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NTRK2

Q16620

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. {ECO:0000250|UniProtKB:P15209, ECO:0000269|PubMed:15494731, ECO:0000269|PubMed:7574684}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM24chr7:138258387chr9:87482158ENST00000343526+1219289_359671.33333333333341051.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM24chr7:138258387chr9:87482158ENST00000415680+1219289_359637.33333333333341017.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM24chr7:138258387chr9:87482158ENST00000343526+1219344_347671.33333333333341051.0Compositional biasNote=Poly-Gln
HgeneTRIM24chr7:138258387chr9:87482158ENST00000343526+12199_15671.33333333333341051.0Compositional biasNote=Poly-Ala
HgeneTRIM24chr7:138258387chr9:87482158ENST00000415680+1219344_347637.33333333333341017.0Compositional biasNote=Poly-Gln
HgeneTRIM24chr7:138258387chr9:87482158ENST00000415680+12199_15637.33333333333341017.0Compositional biasNote=Poly-Ala
HgeneTRIM24chr7:138258387chr9:87482158ENST00000343526+1219158_211671.33333333333341051.0Zinc fingerB box-type 1
HgeneTRIM24chr7:138258387chr9:87482158ENST00000343526+1219218_259671.33333333333341051.0Zinc fingerB box-type 2
HgeneTRIM24chr7:138258387chr9:87482158ENST00000343526+121956_82671.33333333333341051.0Zinc fingerRING-type
HgeneTRIM24chr7:138258387chr9:87482158ENST00000415680+1219158_211637.33333333333341017.0Zinc fingerB box-type 1
HgeneTRIM24chr7:138258387chr9:87482158ENST00000415680+1219218_259637.33333333333341017.0Zinc fingerB box-type 2
HgeneTRIM24chr7:138258387chr9:87482158ENST00000415680+121956_82637.33333333333341017.0Zinc fingerRING-type
TgeneNTRK2chr7:138258387chr9:87482158ENST000002771201219538_807481.3333333333333839.0DomainProtein kinase
TgeneNTRK2chr7:138258387chr9:87482158ENST000003040531215538_807481.3333333333333554.0DomainProtein kinase
TgeneNTRK2chr7:138258387chr9:87482158ENST000003231151017538_807465.3333333333333823.0DomainProtein kinase
TgeneNTRK2chr7:138258387chr9:87482158ENST00000359847012148_1960478.0DomainNote=LRRCT
TgeneNTRK2chr7:138258387chr9:87482158ENST00000359847012197_2820478.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr7:138258387chr9:87482158ENST00000359847012295_3650478.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr7:138258387chr9:87482158ENST0000035984701232_610478.0DomainNote=LRRNT
TgeneNTRK2chr7:138258387chr9:87482158ENST00000359847012538_8070478.0DomainProtein kinase
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762081114538_807465.3333333333333538.0DomainProtein kinase
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762131320538_807465.3333333333333823.0DomainProtein kinase
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762141421538_807481.3333333333333839.0DomainProtein kinase
TgeneNTRK2chr7:138258387chr9:87482158ENST00000395866012148_1960322.0DomainNote=LRRCT
TgeneNTRK2chr7:138258387chr9:87482158ENST00000395866012197_2820322.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr7:138258387chr9:87482158ENST00000395866012295_3650322.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr7:138258387chr9:87482158ENST0000039586601232_610322.0DomainNote=LRRNT
TgeneNTRK2chr7:138258387chr9:87482158ENST00000395866012538_8070322.0DomainProtein kinase
TgeneNTRK2chr7:138258387chr9:87482158ENST00000395882013148_1960478.0DomainNote=LRRCT
TgeneNTRK2chr7:138258387chr9:87482158ENST00000395882013197_2820478.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr7:138258387chr9:87482158ENST00000395882013295_3650478.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr7:138258387chr9:87482158ENST0000039588201332_610478.0DomainNote=LRRNT
TgeneNTRK2chr7:138258387chr9:87482158ENST00000395882013538_8070478.0DomainProtein kinase
TgeneNTRK2chr7:138258387chr9:87482158ENST000002771201219544_552481.3333333333333839.0Nucleotide bindingATP
TgeneNTRK2chr7:138258387chr9:87482158ENST000003040531215544_552481.3333333333333554.0Nucleotide bindingATP
TgeneNTRK2chr7:138258387chr9:87482158ENST000003231151017544_552465.3333333333333823.0Nucleotide bindingATP
TgeneNTRK2chr7:138258387chr9:87482158ENST00000359847012544_5520478.0Nucleotide bindingATP
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762081114544_552465.3333333333333538.0Nucleotide bindingATP
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762131320544_552465.3333333333333823.0Nucleotide bindingATP
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762141421544_552481.3333333333333839.0Nucleotide bindingATP
TgeneNTRK2chr7:138258387chr9:87482158ENST00000395866012544_5520322.0Nucleotide bindingATP
TgeneNTRK2chr7:138258387chr9:87482158ENST00000395882013544_5520478.0Nucleotide bindingATP
TgeneNTRK2chr7:138258387chr9:87482158ENST00000359847012116_1370478.0RepeatNote=LRR 2
TgeneNTRK2chr7:138258387chr9:87482158ENST0000035984701292_1130478.0RepeatNote=LRR 1
TgeneNTRK2chr7:138258387chr9:87482158ENST00000395866012116_1370322.0RepeatNote=LRR 2
TgeneNTRK2chr7:138258387chr9:87482158ENST0000039586601292_1130322.0RepeatNote=LRR 1
TgeneNTRK2chr7:138258387chr9:87482158ENST00000395882013116_1370478.0RepeatNote=LRR 2
TgeneNTRK2chr7:138258387chr9:87482158ENST0000039588201392_1130478.0RepeatNote=LRR 1
TgeneNTRK2chr7:138258387chr9:87482158ENST0000035984701232_4300478.0Topological domainExtracellular
TgeneNTRK2chr7:138258387chr9:87482158ENST00000359847012455_8220478.0Topological domainCytoplasmic
TgeneNTRK2chr7:138258387chr9:87482158ENST0000039586601232_4300322.0Topological domainExtracellular
TgeneNTRK2chr7:138258387chr9:87482158ENST00000395866012455_8220322.0Topological domainCytoplasmic
TgeneNTRK2chr7:138258387chr9:87482158ENST0000039588201332_4300478.0Topological domainExtracellular
TgeneNTRK2chr7:138258387chr9:87482158ENST00000395882013455_8220478.0Topological domainCytoplasmic
TgeneNTRK2chr7:138258387chr9:87482158ENST00000359847012431_4540478.0TransmembraneHelical
TgeneNTRK2chr7:138258387chr9:87482158ENST00000395866012431_4540322.0TransmembraneHelical
TgeneNTRK2chr7:138258387chr9:87482158ENST00000395882013431_4540478.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM24chr7:138258387chr9:87482158ENST00000343526+1219932_987671.33333333333341051.0DomainBromo
HgeneTRIM24chr7:138258387chr9:87482158ENST00000415680+1219932_987637.33333333333341017.0DomainBromo
HgeneTRIM24chr7:138258387chr9:87482158ENST00000343526+1219891_907671.33333333333341051.0MotifNuclear localization signal
HgeneTRIM24chr7:138258387chr9:87482158ENST00000415680+1219891_907637.33333333333341017.0MotifNuclear localization signal
HgeneTRIM24chr7:138258387chr9:87482158ENST00000343526+1219754_779671.33333333333341051.0RegionNote=Nuclear receptor binding site (NRBS)
HgeneTRIM24chr7:138258387chr9:87482158ENST00000415680+1219754_779637.33333333333341017.0RegionNote=Nuclear receptor binding site (NRBS)
HgeneTRIM24chr7:138258387chr9:87482158ENST00000343526+1219826_873671.33333333333341051.0Zinc fingerPHD-type
HgeneTRIM24chr7:138258387chr9:87482158ENST00000415680+1219826_873637.33333333333341017.0Zinc fingerPHD-type
TgeneNTRK2chr7:138258387chr9:87482158ENST000002771201219148_196481.3333333333333839.0DomainNote=LRRCT
TgeneNTRK2chr7:138258387chr9:87482158ENST000002771201219197_282481.3333333333333839.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr7:138258387chr9:87482158ENST000002771201219295_365481.3333333333333839.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr7:138258387chr9:87482158ENST00000277120121932_61481.3333333333333839.0DomainNote=LRRNT
TgeneNTRK2chr7:138258387chr9:87482158ENST000003040531215148_196481.3333333333333554.0DomainNote=LRRCT
TgeneNTRK2chr7:138258387chr9:87482158ENST000003040531215197_282481.3333333333333554.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr7:138258387chr9:87482158ENST000003040531215295_365481.3333333333333554.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr7:138258387chr9:87482158ENST00000304053121532_61481.3333333333333554.0DomainNote=LRRNT
TgeneNTRK2chr7:138258387chr9:87482158ENST000003231151017148_196465.3333333333333823.0DomainNote=LRRCT
TgeneNTRK2chr7:138258387chr9:87482158ENST000003231151017197_282465.3333333333333823.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr7:138258387chr9:87482158ENST000003231151017295_365465.3333333333333823.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr7:138258387chr9:87482158ENST00000323115101732_61465.3333333333333823.0DomainNote=LRRNT
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762081114148_196465.3333333333333538.0DomainNote=LRRCT
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762081114197_282465.3333333333333538.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762081114295_365465.3333333333333538.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr7:138258387chr9:87482158ENST00000376208111432_61465.3333333333333538.0DomainNote=LRRNT
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762131320148_196465.3333333333333823.0DomainNote=LRRCT
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762131320197_282465.3333333333333823.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762131320295_365465.3333333333333823.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr7:138258387chr9:87482158ENST00000376213132032_61465.3333333333333823.0DomainNote=LRRNT
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762141421148_196481.3333333333333839.0DomainNote=LRRCT
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762141421197_282481.3333333333333839.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762141421295_365481.3333333333333839.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr7:138258387chr9:87482158ENST00000376214142132_61481.3333333333333839.0DomainNote=LRRNT
TgeneNTRK2chr7:138258387chr9:87482158ENST000002771201219116_137481.3333333333333839.0RepeatNote=LRR 2
TgeneNTRK2chr7:138258387chr9:87482158ENST00000277120121992_113481.3333333333333839.0RepeatNote=LRR 1
TgeneNTRK2chr7:138258387chr9:87482158ENST000003040531215116_137481.3333333333333554.0RepeatNote=LRR 2
TgeneNTRK2chr7:138258387chr9:87482158ENST00000304053121592_113481.3333333333333554.0RepeatNote=LRR 1
TgeneNTRK2chr7:138258387chr9:87482158ENST000003231151017116_137465.3333333333333823.0RepeatNote=LRR 2
TgeneNTRK2chr7:138258387chr9:87482158ENST00000323115101792_113465.3333333333333823.0RepeatNote=LRR 1
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762081114116_137465.3333333333333538.0RepeatNote=LRR 2
TgeneNTRK2chr7:138258387chr9:87482158ENST00000376208111492_113465.3333333333333538.0RepeatNote=LRR 1
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762131320116_137465.3333333333333823.0RepeatNote=LRR 2
TgeneNTRK2chr7:138258387chr9:87482158ENST00000376213132092_113465.3333333333333823.0RepeatNote=LRR 1
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762141421116_137481.3333333333333839.0RepeatNote=LRR 2
TgeneNTRK2chr7:138258387chr9:87482158ENST00000376214142192_113481.3333333333333839.0RepeatNote=LRR 1
TgeneNTRK2chr7:138258387chr9:87482158ENST00000277120121932_430481.3333333333333839.0Topological domainExtracellular
TgeneNTRK2chr7:138258387chr9:87482158ENST000002771201219455_822481.3333333333333839.0Topological domainCytoplasmic
TgeneNTRK2chr7:138258387chr9:87482158ENST00000304053121532_430481.3333333333333554.0Topological domainExtracellular
TgeneNTRK2chr7:138258387chr9:87482158ENST000003040531215455_822481.3333333333333554.0Topological domainCytoplasmic
TgeneNTRK2chr7:138258387chr9:87482158ENST00000323115101732_430465.3333333333333823.0Topological domainExtracellular
TgeneNTRK2chr7:138258387chr9:87482158ENST000003231151017455_822465.3333333333333823.0Topological domainCytoplasmic
TgeneNTRK2chr7:138258387chr9:87482158ENST00000376208111432_430465.3333333333333538.0Topological domainExtracellular
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762081114455_822465.3333333333333538.0Topological domainCytoplasmic
TgeneNTRK2chr7:138258387chr9:87482158ENST00000376213132032_430465.3333333333333823.0Topological domainExtracellular
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762131320455_822465.3333333333333823.0Topological domainCytoplasmic
TgeneNTRK2chr7:138258387chr9:87482158ENST00000376214142132_430481.3333333333333839.0Topological domainExtracellular
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762141421455_822481.3333333333333839.0Topological domainCytoplasmic
TgeneNTRK2chr7:138258387chr9:87482158ENST000002771201219431_454481.3333333333333839.0TransmembraneHelical
TgeneNTRK2chr7:138258387chr9:87482158ENST000003040531215431_454481.3333333333333554.0TransmembraneHelical
TgeneNTRK2chr7:138258387chr9:87482158ENST000003231151017431_454465.3333333333333823.0TransmembraneHelical
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762081114431_454465.3333333333333538.0TransmembraneHelical
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762131320431_454465.3333333333333823.0TransmembraneHelical
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762141421431_454481.3333333333333839.0TransmembraneHelical


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Fusion Gene Sequence for TRIM24-NTRK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000343526_ENST00000376214_TCGA-55-8091-01A_TRIM24_chr7_138258387_+_NTRK2_chr9_87482158_length(transcript)=5455nt_BP=2229nt
GACAGATACCCTCCTTCCGGCCGCGCCACTCGGGAGGCGGATCCCGTGGGCCTGAGGAGGCTTCCCCCGCCCGGTTTGCTTTCCCTCCCT
CGCTGGCGCTGCCGCGAGTCCACCGAGCGGCCTCTGAGGAGCAGCCGCAGGAGGAGGAGGAGGTCGTCGGGGGCGGCGGGCGGAGACCGC
GCTCTCGCTTCCCCGGCGGCGGCAAGGGCAGGACAATGGAGGTGGCGGTGGAGAAGGCGGTGGCGGCGGCGGCAGCGGCCTCGGCTGCGG
CCTCCGGGGGGCCCTCGGCGGCGCCGAGCGGGGAGAACGAGGCCGAGAGTCGGCAGGGCCCGGACTCGGAGCGCGGCGGCGAGGCGGCCC
GGCTCAACCTGTTGGACACTTGCGCCGTGTGCCACCAGAACATCCAGAGCCGGGCGCCCAAGCTGCTGCCCTGCCTGCACTCTTTCTGCC
AGCGCTGCCTGCCCGCGCCCCAGCGCTACCTCATGCTGCCCGCGCCCATGCTGGGCTCGGCCGAGACCCCGCCACCCGTCCCTGCCCCCG
GCTCGCCGGTCAGCGGCTCGTCGCCGTTCGCCACCCAAGTTGGAGTCATTCGTTGCCCAGTTTGCAGCCAAGAATGTGCAGAGAGACACA
TCATAGATAACTTTTTTGTGAAGGACACTACTGAGGTTCCCAGCAGTACAGTAGAAAAGTCAAATCAGGTATGTACAAGCTGTGAGGACA
ACGCAGAAGCCAATGGGTTTTGTGTAGAGTGTGTTGAATGGCTCTGCAAGACGTGTATCAGAGCTCATCAGAGGGTAAAGTTCACAAAAG
ACCACACTGTCAGACAGAAAGAGGAAGTATCTCCAGAGGCAGTTGGTGTCACCAGCCAGCGACCAGTGTTTTGTCCTTTTCATAAAAAGG
AGCAGCTGAAGCTGTACTGTGAGACATGTGACAAACTGACATGTCGAGACTGTCAGTTGTTAGAACATAAAGAGCATAGATACCAATTTA
TAGAAGAAGCTTTTCAGAATCAGAAAGTGATCATAGATACACTAATCACCAAACTGATGGAAAAAACAAAATACATAAAATTCACAGGAA
ATCAGATCCAAAACAGAATTATTGAAGTAAATCAAAATCAAAAGCAGGTGGAACAGGATATTAAAGTTGCTATATTTACACTGATGGTAG
AAATAAATAAAAAAGGAAAAGCTCTACTGCATCAGTTAGAGAGCCTTGCAAAGGACCATCGCATGAAACTTATGCAACAACAACAGGAAG
TGGCTGGACTCTCTAAACAATTGGAGCATGTCATGCATTTTTCTAAATGGGCAGTTTCCAGTGGCAGCAGTACAGCATTACTTTATAGCA
AACGACTGATTACATACCGGTTACGGCACCTCCTTCGTGCAAGGTGTGATGCATCCCCAGTGACCAACAACACCATCCAATTTCACTGTG
ATCCTAGTTTCTGGGCTCAAAATATCATCAACTTAGGTTCTTTAGTAATCGAGGATAAAGAGAGCCAGCCACAAATGCCTAAGCAGAATC
CTGTCGTGGAACAGAATTCACAGCCACCAAGTGGTTTATCATCAAACCAGTTATCCAAGTTCCCAACACAGATCAGCCTAGCTCAATTAC
GGCTCCAGCATATGCAGCAACAGGTAATGGCTCAGAGGCAACAGGTGCAACGGAGGCCAGCACCTGTGGGTTTACCAAACCCTAGAATGC
AGGGGCCCATCCAGCAACCTTCCATCTCTCATCAGCAACCGCCTCCACGTTTGATAAACTTTCAGAATCACAGCCCCAAACCCAATGGAC
CAGTTCTTCCTCCTCATCCTCAACAACTGAGATATCCACCAAACCAGAACATACCACGACAAGCAATAAAGCCAAACCCCCTACAGATGG
CTTTCTTGGCTCAACAAGCCATAAAACAGTGGCAGATCAGCAGTGGACAGGGAACCCCATCAACTACCAACAGCACATCCTCTACTCCTT
CCAGCCCCACGATTACTAGTGCAGCAGGATATGATGGAAAGGCTTTTGGTTCACCTATGATCGATTTGAGCTCACCAGTGGGAGGGTCTT
ATAATCTTCCCTCTCTTCCGGATATTGACTGTTCAAGTACTATTATGCTGGACAATATTGTGAGGAAAGATACTAATATAGATCATGGCC
AGCCAAGACCACCCTCAAACAGAACGGTCCAGTCACCAAATTCATCAGTGCCATCTCCAGGCCTTGCAGGCCCAGCCTCCGTTATCAGCA
ATGATGATGACTCTGCCAGCCCACTCCATCACATCTCCAATGGGAGTAACACTCCATCTTCTTCGGAAGGTGGCCCAGATGCTGTCATTA
TTGGAATGACCAAGATCCCTGTCATTGAAAATCCCCAGTACTTTGGCATCACCAACAGTCAGCTCAAGCCAGACACATTTGTTCAGCACA
TCAAGCGACATAACATTGTTCTGAAAAGGGAGCTAGGCGAAGGAGCCTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTG
AGCAGGACAAGATCTTGGTGGCAGTGAAGACCCTGAAGGATGCCAGTGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGA
CCAACCTCCAGCATGAGCACATCGTCAAGTTCTATGGCGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATG
GGGACCTCAACAAGTTCCTCAGGGCACACGGCCCTGATGCCGTGCTGATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGA
TGCTGCATATAGCCCAGCAGATCGCCGCGGGCATGGTCTACCTGGCGTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCC
TGGTCGGGGAGAACTTGCTGGTGAAAATCGGGGACTTTGGGATGTCCCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACA
CAATGCTGCCCATTCGCTGGATGCCTCCAGAGAGCATCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGT
TGTGGGAGATTTTCACCTATGGCAAACAGCCCTGGTACCAGCTGTCAAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGC
AGCGACCCCGCACGTGCCCCCAGGAGGTGTATGAGCTGATGCTGGGGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCA
TCCATACCCTCCTTCAGAACTTGGCCAAGGCATCTCCGGTCTACCTGGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCC
AACGTACTCCTCAGACGGGCTGAGAGGATGAACATCTTTTAACTGCCGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTA
ACATCAAAGACTCCGAGAAGCTCTCGAGGGAAGCAGTGTGTACTTCTTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCT
TTCTCTCTTTCCATCTCCCTTGGTTGTTCCTTTTTCTTTTTTTAAATTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCT
TACCCTTTCTTTTGAATCAATCTGGCTTCTGCATTACTATTAACTCTGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCA
GACACTCCAGTTTGCCCACCACAACTAACAATGCCTTGTTGTATTCCTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCAC
TTAAACTTTGTCACTTCTGCTGTACAGATATCGAGAGTTTCTATGGATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTT
TGGATGGCTTAAGCCTGTGTATAAAAAAGAAAACTTGTGTTCAATCTGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAA
GATTTATTATGAACCGCAATATGGGAGGAACAAAGACAACCACTGGGATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTG
TTAGCTGGGAAGAATGTATTCGGCACCTTCCCCTGAGGACCTTTCTGAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTT
TTCCCATCACCAGAAATGATAGCGTGCAGTAGAGAGCAAAGATGGCTTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTT
TTGTCTTCGTAGGTTGTGATGATAGCACTGGTTTGTTTCTCAAGCGCTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGAT
TCATGTCCAGAGCTCATTTCGGGGTCAGGTGGGAAAGCCAAGAACTTGGAAAAGATAAGACAAGCTATAAATTCGGAGGCAAGTTTCTTT
TACAATGAACTTTTCAGATCTCACTTCCCTCCGACCCCTAACTTCCATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTGCATGG
TCTTCGTCGATTAATACCTTGTGTGCAGACACTACTGCTCCAGACGTCGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACT
TATACAATTAGGGGAAGCTAATGGAGTTTATTAGCTGAGTATCAATGTCTCTGCGTTGTACGGTGGTGATGGGTTTTAATGAATATGGAC
CCTGAAGCCTGGAAATCCTCATCCACGTCGAACCCACAGGACTGTGGGAAGGGCAGAATCAATCCCTAAGGGAAAGGAAACCTCACCCTG
AGGGCATCACATGCACTCATGTTCAGTGTACACAGGTCAAGTCCCTTGCTCTGGGCTCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTAC
TCCATTGTCAGTATGCTGTTTTTGTTTCCTTCACTCCATTCAAAAAGTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCTGTG
CCCAGACCAAGCACTGGAAGTGTGCTTCTAGGCATAGTCATTGGTTTTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATT
TGAATGGTCAGATATACCAAGAAAGAAAAATATTTCTGTTCCTCAAGAAAACTTGCTACCCTCTGTGAGGGGAATTTTGCTAAACTTGAC
ATCTTTATAACATGAGCCAGATTGAAAGGGAGTGATTTTCATTCATCTTAGGTCATGTTATTTCATATTTGTTTCTGAAGGTGCGATAGC
TCTGTTTTAGGTTTTGCTTGCGCCTGTTAATTACTGGAACACCTTATTTTTCATTAAAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAA
GTGCAAATTAACAGAACAAAAGGAAATCCAGTAGCAACTGCAGTCAAGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAAGTTAT

>In-frame_ENST00000343526_ENST00000376214_TCGA-55-8091-01A_TRIM24_chr7_138258387_+_NTRK2_chr9_87482158_length(amino acids)=1069AA_start in transcript=92_stop in transcript=3301
MALPRVHRAASEEQPQEEEEVVGGGGRRPRSRFPGGGKGRTMEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAAR
LNLLDTCAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHI
IDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKE
QLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVE
INKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCD
PSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQRQQVQRRPAPVGLPNPRMQ
GPIQQPSISHQQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTPS
SPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQSPNSSVPSPGLAGPASVISN
DDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPE
QDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQM
LHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVL

--------------------------------------------------------------
>In-frame_ENST00000343526_ENST00000376213_TCGA-55-8091-01A_TRIM24_chr7_138258387_+_NTRK2_chr9_87482158_length(transcript)=5455nt_BP=2229nt
GACAGATACCCTCCTTCCGGCCGCGCCACTCGGGAGGCGGATCCCGTGGGCCTGAGGAGGCTTCCCCCGCCCGGTTTGCTTTCCCTCCCT
CGCTGGCGCTGCCGCGAGTCCACCGAGCGGCCTCTGAGGAGCAGCCGCAGGAGGAGGAGGAGGTCGTCGGGGGCGGCGGGCGGAGACCGC
GCTCTCGCTTCCCCGGCGGCGGCAAGGGCAGGACAATGGAGGTGGCGGTGGAGAAGGCGGTGGCGGCGGCGGCAGCGGCCTCGGCTGCGG
CCTCCGGGGGGCCCTCGGCGGCGCCGAGCGGGGAGAACGAGGCCGAGAGTCGGCAGGGCCCGGACTCGGAGCGCGGCGGCGAGGCGGCCC
GGCTCAACCTGTTGGACACTTGCGCCGTGTGCCACCAGAACATCCAGAGCCGGGCGCCCAAGCTGCTGCCCTGCCTGCACTCTTTCTGCC
AGCGCTGCCTGCCCGCGCCCCAGCGCTACCTCATGCTGCCCGCGCCCATGCTGGGCTCGGCCGAGACCCCGCCACCCGTCCCTGCCCCCG
GCTCGCCGGTCAGCGGCTCGTCGCCGTTCGCCACCCAAGTTGGAGTCATTCGTTGCCCAGTTTGCAGCCAAGAATGTGCAGAGAGACACA
TCATAGATAACTTTTTTGTGAAGGACACTACTGAGGTTCCCAGCAGTACAGTAGAAAAGTCAAATCAGGTATGTACAAGCTGTGAGGACA
ACGCAGAAGCCAATGGGTTTTGTGTAGAGTGTGTTGAATGGCTCTGCAAGACGTGTATCAGAGCTCATCAGAGGGTAAAGTTCACAAAAG
ACCACACTGTCAGACAGAAAGAGGAAGTATCTCCAGAGGCAGTTGGTGTCACCAGCCAGCGACCAGTGTTTTGTCCTTTTCATAAAAAGG
AGCAGCTGAAGCTGTACTGTGAGACATGTGACAAACTGACATGTCGAGACTGTCAGTTGTTAGAACATAAAGAGCATAGATACCAATTTA
TAGAAGAAGCTTTTCAGAATCAGAAAGTGATCATAGATACACTAATCACCAAACTGATGGAAAAAACAAAATACATAAAATTCACAGGAA
ATCAGATCCAAAACAGAATTATTGAAGTAAATCAAAATCAAAAGCAGGTGGAACAGGATATTAAAGTTGCTATATTTACACTGATGGTAG
AAATAAATAAAAAAGGAAAAGCTCTACTGCATCAGTTAGAGAGCCTTGCAAAGGACCATCGCATGAAACTTATGCAACAACAACAGGAAG
TGGCTGGACTCTCTAAACAATTGGAGCATGTCATGCATTTTTCTAAATGGGCAGTTTCCAGTGGCAGCAGTACAGCATTACTTTATAGCA
AACGACTGATTACATACCGGTTACGGCACCTCCTTCGTGCAAGGTGTGATGCATCCCCAGTGACCAACAACACCATCCAATTTCACTGTG
ATCCTAGTTTCTGGGCTCAAAATATCATCAACTTAGGTTCTTTAGTAATCGAGGATAAAGAGAGCCAGCCACAAATGCCTAAGCAGAATC
CTGTCGTGGAACAGAATTCACAGCCACCAAGTGGTTTATCATCAAACCAGTTATCCAAGTTCCCAACACAGATCAGCCTAGCTCAATTAC
GGCTCCAGCATATGCAGCAACAGGTAATGGCTCAGAGGCAACAGGTGCAACGGAGGCCAGCACCTGTGGGTTTACCAAACCCTAGAATGC
AGGGGCCCATCCAGCAACCTTCCATCTCTCATCAGCAACCGCCTCCACGTTTGATAAACTTTCAGAATCACAGCCCCAAACCCAATGGAC
CAGTTCTTCCTCCTCATCCTCAACAACTGAGATATCCACCAAACCAGAACATACCACGACAAGCAATAAAGCCAAACCCCCTACAGATGG
CTTTCTTGGCTCAACAAGCCATAAAACAGTGGCAGATCAGCAGTGGACAGGGAACCCCATCAACTACCAACAGCACATCCTCTACTCCTT
CCAGCCCCACGATTACTAGTGCAGCAGGATATGATGGAAAGGCTTTTGGTTCACCTATGATCGATTTGAGCTCACCAGTGGGAGGGTCTT
ATAATCTTCCCTCTCTTCCGGATATTGACTGTTCAAGTACTATTATGCTGGACAATATTGTGAGGAAAGATACTAATATAGATCATGGCC
AGCCAAGACCACCCTCAAACAGAACGGTCCAGTCACCAAATTCATCAGTGCCATCTCCAGGCCTTGCAGGCCCAGCCTCCGTTATCAGCA
ATGATGATGACTCTGCCAGCCCACTCCATCACATCTCCAATGGGAGTAACACTCCATCTTCTTCGGAAGGTGGCCCAGATGCTGTCATTA
TTGGAATGACCAAGATCCCTGTCATTGAAAATCCCCAGTACTTTGGCATCACCAACAGTCAGCTCAAGCCAGACACATTTGTTCAGCACA
TCAAGCGACATAACATTGTTCTGAAAAGGGAGCTAGGCGAAGGAGCCTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTG
AGCAGGACAAGATCTTGGTGGCAGTGAAGACCCTGAAGGATGCCAGTGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGA
CCAACCTCCAGCATGAGCACATCGTCAAGTTCTATGGCGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATG
GGGACCTCAACAAGTTCCTCAGGGCACACGGCCCTGATGCCGTGCTGATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGA
TGCTGCATATAGCCCAGCAGATCGCCGCGGGCATGGTCTACCTGGCGTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCC
TGGTCGGGGAGAACTTGCTGGTGAAAATCGGGGACTTTGGGATGTCCCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACA
CAATGCTGCCCATTCGCTGGATGCCTCCAGAGAGCATCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGT
TGTGGGAGATTTTCACCTATGGCAAACAGCCCTGGTACCAGCTGTCAAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGC
AGCGACCCCGCACGTGCCCCCAGGAGGTGTATGAGCTGATGCTGGGGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCA
TCCATACCCTCCTTCAGAACTTGGCCAAGGCATCTCCGGTCTACCTGGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCC
AACGTACTCCTCAGACGGGCTGAGAGGATGAACATCTTTTAACTGCCGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTA
ACATCAAAGACTCCGAGAAGCTCTCGAGGGAAGCAGTGTGTACTTCTTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCT
TTCTCTCTTTCCATCTCCCTTGGTTGTTCCTTTTTCTTTTTTTAAATTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCT
TACCCTTTCTTTTGAATCAATCTGGCTTCTGCATTACTATTAACTCTGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCA
GACACTCCAGTTTGCCCACCACAACTAACAATGCCTTGTTGTATTCCTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCAC
TTAAACTTTGTCACTTCTGCTGTACAGATATCGAGAGTTTCTATGGATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTT
TGGATGGCTTAAGCCTGTGTATAAAAAAGAAAACTTGTGTTCAATCTGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAA
GATTTATTATGAACCGCAATATGGGAGGAACAAAGACAACCACTGGGATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTG
TTAGCTGGGAAGAATGTATTCGGCACCTTCCCCTGAGGACCTTTCTGAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTT
TTCCCATCACCAGAAATGATAGCGTGCAGTAGAGAGCAAAGATGGCTTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTT
TTGTCTTCGTAGGTTGTGATGATAGCACTGGTTTGTTTCTCAAGCGCTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGAT
TCATGTCCAGAGCTCATTTCGGGGTCAGGTGGGAAAGCCAAGAACTTGGAAAAGATAAGACAAGCTATAAATTCGGAGGCAAGTTTCTTT
TACAATGAACTTTTCAGATCTCACTTCCCTCCGACCCCTAACTTCCATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTGCATGG
TCTTCGTCGATTAATACCTTGTGTGCAGACACTACTGCTCCAGACGTCGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACT
TATACAATTAGGGGAAGCTAATGGAGTTTATTAGCTGAGTATCAATGTCTCTGCGTTGTACGGTGGTGATGGGTTTTAATGAATATGGAC
CCTGAAGCCTGGAAATCCTCATCCACGTCGAACCCACAGGACTGTGGGAAGGGCAGAATCAATCCCTAAGGGAAAGGAAACCTCACCCTG
AGGGCATCACATGCACTCATGTTCAGTGTACACAGGTCAAGTCCCTTGCTCTGGGCTCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTAC
TCCATTGTCAGTATGCTGTTTTTGTTTCCTTCACTCCATTCAAAAAGTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCTGTG
CCCAGACCAAGCACTGGAAGTGTGCTTCTAGGCATAGTCATTGGTTTTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATT
TGAATGGTCAGATATACCAAGAAAGAAAAATATTTCTGTTCCTCAAGAAAACTTGCTACCCTCTGTGAGGGGAATTTTGCTAAACTTGAC
ATCTTTATAACATGAGCCAGATTGAAAGGGAGTGATTTTCATTCATCTTAGGTCATGTTATTTCATATTTGTTTCTGAAGGTGCGATAGC
TCTGTTTTAGGTTTTGCTTGCGCCTGTTAATTACTGGAACACCTTATTTTTCATTAAAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAA
GTGCAAATTAACAGAACAAAAGGAAATCCAGTAGCAACTGCAGTCAAGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAAGTTAT

>In-frame_ENST00000343526_ENST00000376213_TCGA-55-8091-01A_TRIM24_chr7_138258387_+_NTRK2_chr9_87482158_length(amino acids)=1069AA_start in transcript=92_stop in transcript=3301
MALPRVHRAASEEQPQEEEEVVGGGGRRPRSRFPGGGKGRTMEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAAR
LNLLDTCAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHI
IDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKE
QLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVE
INKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCD
PSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQRQQVQRRPAPVGLPNPRMQ
GPIQQPSISHQQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTPS
SPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQSPNSSVPSPGLAGPASVISN
DDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPE
QDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQM
LHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVL

--------------------------------------------------------------
>In-frame_ENST00000415680_ENST00000376214_TCGA-55-8091-01A_TRIM24_chr7_138258387_+_NTRK2_chr9_87482158_length(transcript)=5252nt_BP=2026nt
CCGCGAGTCCACCGAGCGGCCTCTGAGGAGCAGCCGCAGGAGGAGGAGGAGGTCGTCGGGGGCGGCGGGCGGAGACCGCGCTCTCGCTTC
CCCGGCGGCGGCAAGGGCAGGACAATGGAGGTGGCGGTGGAGAAGGCGGTGGCGGCGGCGGCAGCGGCCTCGGCTGCGGCCTCCGGGGGG
CCCTCGGCGGCGCCGAGCGGGGAGAACGAGGCCGAGAGTCGGCAGGGCCCGGACTCGGAGCGCGGCGGCGAGGCGGCCCGGCTCAACCTG
TTGGACACTTGCGCCGTGTGCCACCAGAACATCCAGAGCCGGGCGCCCAAGCTGCTGCCCTGCCTGCACTCTTTCTGCCAGCGCTGCCTG
CCCGCGCCCCAGCGCTACCTCATGCTGCCCGCGCCCATGCTGGGCTCGGCCGAGACCCCGCCACCCGTCCCTGCCCCCGGCTCGCCGGTC
AGCGGCTCGTCGCCGTTCGCCACCCAAGTTGGAGTCATTCGTTGCCCAGTTTGCAGCCAAGAATGTGCAGAGAGACACATCATAGATAAC
TTTTTTGTGAAGGACACTACTGAGGTTCCCAGCAGTACAGTAGAAAAGTCAAATCAGGTATGTACAAGCTGTGAGGACAACGCAGAAGCC
AATGGGTTTTGTGTAGAGTGTGTTGAATGGCTCTGCAAGACGTGTATCAGAGCTCATCAGAGGGTAAAGTTCACAAAAGACCACACTGTC
AGACAGAAAGAGGAAGTATCTCCAGAGGCAGTTGGTGTCACCAGCCAGCGACCAGTGTTTTGTCCTTTTCATAAAAAGGAGCAGCTGAAG
CTGTACTGTGAGACATGTGACAAACTGACATGTCGAGACTGTCAGTTGTTAGAACATAAAGAGCATAGATACCAATTTATAGAAGAAGCT
TTTCAGAATCAGAAAGTGATCATAGATACACTAATCACCAAACTGATGGAAAAAACAAAATACATAAAATTCACAGGAAATCAGATCCAA
AACAGAATTATTGAAGTAAATCAAAATCAAAAGCAGGTGGAACAGGATATTAAAGTTGCTATATTTACACTGATGGTAGAAATAAATAAA
AAAGGAAAAGCTCTACTGCATCAGTTAGAGAGCCTTGCAAAGGACCATCGCATGAAACTTATGCAACAACAACAGGAAGTGGCTGGACTC
TCTAAACAATTGGAGCATGTCATGCATTTTTCTAAATGGGCAGTTTCCAGTGGCAGCAGTACAGCATTACTTTATAGCAAACGACTGATT
ACATACCGGTTACGGCACCTCCTTCGTGCAAGGTGTGATGCATCCCCAGTGACCAACAACACCATCCAATTTCACTGTGATCCTAGTTTC
TGGGCTCAAAATATCATCAACTTAGGTTCTTTAGTAATCGAGGATAAAGAGAGCCAGCCACAAATGCCTAAGCAGAATCCTGTCGTGGAA
CAGAATTCACAGCCACCAAGTGGTTTATCATCAAACCAGTTATCCAAGTTCCCAACACAGATCAGCCTAGCTCAATTACGGCTCCAGCAT
ATGCAGCAACAGCAACCGCCTCCACGTTTGATAAACTTTCAGAATCACAGCCCCAAACCCAATGGACCAGTTCTTCCTCCTCATCCTCAA
CAACTGAGATATCCACCAAACCAGAACATACCACGACAAGCAATAAAGCCAAACCCCCTACAGATGGCTTTCTTGGCTCAACAAGCCATA
AAACAGTGGCAGATCAGCAGTGGACAGGGAACCCCATCAACTACCAACAGCACATCCTCTACTCCTTCCAGCCCCACGATTACTAGTGCA
GCAGGATATGATGGAAAGGCTTTTGGTTCACCTATGATCGATTTGAGCTCACCAGTGGGAGGGTCTTATAATCTTCCCTCTCTTCCGGAT
ATTGACTGTTCAAGTACTATTATGCTGGACAATATTGTGAGGAAAGATACTAATATAGATCATGGCCAGCCAAGACCACCCTCAAACAGA
ACGGTCCAGTCACCAAATTCATCAGTGCCATCTCCAGGCCTTGCAGGCCCAGCCTCCGTTATCAGCAATGATGATGACTCTGCCAGCCCA
CTCCATCACATCTCCAATGGGAGTAACACTCCATCTTCTTCGGAAGGTGGCCCAGATGCTGTCATTATTGGAATGACCAAGATCCCTGTC
ATTGAAAATCCCCAGTACTTTGGCATCACCAACAGTCAGCTCAAGCCAGACACATTTGTTCAGCACATCAAGCGACATAACATTGTTCTG
AAAAGGGAGCTAGGCGAAGGAGCCTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGACAAGATCTTGGTGGCA
GTGAAGACCCTGAAGGATGCCAGTGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATC
GTCAAGTTCTATGGCGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTCAACAAGTTCCTCAGG
GCACACGGCCCTGATGCCGTGCTGATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCATATAGCCCAGCAGATC
GCCGCGGGCATGGTCTACCTGGCGTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGGGAGAACTTGCTGGTG
AAAATCGGGGACTTTGGGATGTCCCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTGCCCATTCGCTGGATG
CCTCCAGAGAGCATCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAGATTTTCACCTATGGC
AAACAGCCCTGGTACCAGCTGTCAAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCCCGCACGTGCCCCCAG
GAGGTGTATGAGCTGATGCTGGGGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACCCTCCTTCAGAACTTG
GCCAAGGCATCTCCGGTCTACCTGGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACTCCTCAGACGGGCTGA
GAGGATGAACATCTTTTAACTGCCGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAAGACTCCGAGAAGCTC
TCGAGGGAAGCAGTGTGTACTTCTTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCTTTCCATCTCCCTTGG
TTGTTCCTTTTTCTTTTTTTAAATTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTTCTTTTGAATCAATCT
GGCTTCTGCATTACTATTAACTCTGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCCAGTTTGCCCACCACA
ACTAACAATGCCTTGTTGTATTCCTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTTTGTCACTTCTGCTGT
ACAGATATCGAGAGTTTCTATGGATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGCTTAAGCCTGTGTATA
AAAAAGAAAACTTGTGTTCAATCTGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATTATGAACCGCAATATG
GGAGGAACAAAGACAACCACTGGGATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGGGAAGAATGTATTCGG
CACCTTCCCCTGAGGACCTTTCTGAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCATCACCAGAAATGATAGC
GTGCAGTAGAGAGCAAAGATGGCTTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTCGTAGGTTGTGATGAT
AGCACTGGTTTGTTTCTCAAGCGCTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGATTCATGTCCAGAGCTCATTTCGGG
GTCAGGTGGGAAAGCCAAGAACTTGGAAAAGATAAGACAAGCTATAAATTCGGAGGCAAGTTTCTTTTACAATGAACTTTTCAGATCTCA
CTTCCCTCCGACCCCTAACTTCCATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTGCATGGTCTTCGTCGATTAATACCTTGTG
TGCAGACACTACTGCTCCAGACGTCGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACTTATACAATTAGGGGAAGCTAATG
GAGTTTATTAGCTGAGTATCAATGTCTCTGCGTTGTACGGTGGTGATGGGTTTTAATGAATATGGACCCTGAAGCCTGGAAATCCTCATC
CACGTCGAACCCACAGGACTGTGGGAAGGGCAGAATCAATCCCTAAGGGAAAGGAAACCTCACCCTGAGGGCATCACATGCACTCATGTT
CAGTGTACACAGGTCAAGTCCCTTGCTCTGGGCTCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTACTCCATTGTCAGTATGCTGTTTTT
GTTTCCTTCACTCCATTCAAAAAGTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCTGTGCCCAGACCAAGCACTGGAAGTGT
GCTTCTAGGCATAGTCATTGGTTTTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATTTGAATGGTCAGATATACCAAGAA
AGAAAAATATTTCTGTTCCTCAAGAAAACTTGCTACCCTCTGTGAGGGGAATTTTGCTAAACTTGACATCTTTATAACATGAGCCAGATT
GAAAGGGAGTGATTTTCATTCATCTTAGGTCATGTTATTTCATATTTGTTTCTGAAGGTGCGATAGCTCTGTTTTAGGTTTTGCTTGCGC
CTGTTAATTACTGGAACACCTTATTTTTCATTAAAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAAGTGCAAATTAACAGAACAAAAGG
AAATCCAGTAGCAACTGCAGTCAAGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAAGTTATATGCTGGCCTATGAGAGATGAGA

>In-frame_ENST00000415680_ENST00000376214_TCGA-55-8091-01A_TRIM24_chr7_138258387_+_NTRK2_chr9_87482158_length(amino acids)=994AA_start in transcript=114_stop in transcript=3098
MEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLM
LPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECV
EWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVII
DTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVM
HFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCDPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSG
LSSNQLSKFPTQISLAQLRLQHMQQQQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSG
QGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQSPNSS
VPSPGLAGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGA
FGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVL
MAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYR
KFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYL

--------------------------------------------------------------
>In-frame_ENST00000415680_ENST00000376213_TCGA-55-8091-01A_TRIM24_chr7_138258387_+_NTRK2_chr9_87482158_length(transcript)=5252nt_BP=2026nt
CCGCGAGTCCACCGAGCGGCCTCTGAGGAGCAGCCGCAGGAGGAGGAGGAGGTCGTCGGGGGCGGCGGGCGGAGACCGCGCTCTCGCTTC
CCCGGCGGCGGCAAGGGCAGGACAATGGAGGTGGCGGTGGAGAAGGCGGTGGCGGCGGCGGCAGCGGCCTCGGCTGCGGCCTCCGGGGGG
CCCTCGGCGGCGCCGAGCGGGGAGAACGAGGCCGAGAGTCGGCAGGGCCCGGACTCGGAGCGCGGCGGCGAGGCGGCCCGGCTCAACCTG
TTGGACACTTGCGCCGTGTGCCACCAGAACATCCAGAGCCGGGCGCCCAAGCTGCTGCCCTGCCTGCACTCTTTCTGCCAGCGCTGCCTG
CCCGCGCCCCAGCGCTACCTCATGCTGCCCGCGCCCATGCTGGGCTCGGCCGAGACCCCGCCACCCGTCCCTGCCCCCGGCTCGCCGGTC
AGCGGCTCGTCGCCGTTCGCCACCCAAGTTGGAGTCATTCGTTGCCCAGTTTGCAGCCAAGAATGTGCAGAGAGACACATCATAGATAAC
TTTTTTGTGAAGGACACTACTGAGGTTCCCAGCAGTACAGTAGAAAAGTCAAATCAGGTATGTACAAGCTGTGAGGACAACGCAGAAGCC
AATGGGTTTTGTGTAGAGTGTGTTGAATGGCTCTGCAAGACGTGTATCAGAGCTCATCAGAGGGTAAAGTTCACAAAAGACCACACTGTC
AGACAGAAAGAGGAAGTATCTCCAGAGGCAGTTGGTGTCACCAGCCAGCGACCAGTGTTTTGTCCTTTTCATAAAAAGGAGCAGCTGAAG
CTGTACTGTGAGACATGTGACAAACTGACATGTCGAGACTGTCAGTTGTTAGAACATAAAGAGCATAGATACCAATTTATAGAAGAAGCT
TTTCAGAATCAGAAAGTGATCATAGATACACTAATCACCAAACTGATGGAAAAAACAAAATACATAAAATTCACAGGAAATCAGATCCAA
AACAGAATTATTGAAGTAAATCAAAATCAAAAGCAGGTGGAACAGGATATTAAAGTTGCTATATTTACACTGATGGTAGAAATAAATAAA
AAAGGAAAAGCTCTACTGCATCAGTTAGAGAGCCTTGCAAAGGACCATCGCATGAAACTTATGCAACAACAACAGGAAGTGGCTGGACTC
TCTAAACAATTGGAGCATGTCATGCATTTTTCTAAATGGGCAGTTTCCAGTGGCAGCAGTACAGCATTACTTTATAGCAAACGACTGATT
ACATACCGGTTACGGCACCTCCTTCGTGCAAGGTGTGATGCATCCCCAGTGACCAACAACACCATCCAATTTCACTGTGATCCTAGTTTC
TGGGCTCAAAATATCATCAACTTAGGTTCTTTAGTAATCGAGGATAAAGAGAGCCAGCCACAAATGCCTAAGCAGAATCCTGTCGTGGAA
CAGAATTCACAGCCACCAAGTGGTTTATCATCAAACCAGTTATCCAAGTTCCCAACACAGATCAGCCTAGCTCAATTACGGCTCCAGCAT
ATGCAGCAACAGCAACCGCCTCCACGTTTGATAAACTTTCAGAATCACAGCCCCAAACCCAATGGACCAGTTCTTCCTCCTCATCCTCAA
CAACTGAGATATCCACCAAACCAGAACATACCACGACAAGCAATAAAGCCAAACCCCCTACAGATGGCTTTCTTGGCTCAACAAGCCATA
AAACAGTGGCAGATCAGCAGTGGACAGGGAACCCCATCAACTACCAACAGCACATCCTCTACTCCTTCCAGCCCCACGATTACTAGTGCA
GCAGGATATGATGGAAAGGCTTTTGGTTCACCTATGATCGATTTGAGCTCACCAGTGGGAGGGTCTTATAATCTTCCCTCTCTTCCGGAT
ATTGACTGTTCAAGTACTATTATGCTGGACAATATTGTGAGGAAAGATACTAATATAGATCATGGCCAGCCAAGACCACCCTCAAACAGA
ACGGTCCAGTCACCAAATTCATCAGTGCCATCTCCAGGCCTTGCAGGCCCAGCCTCCGTTATCAGCAATGATGATGACTCTGCCAGCCCA
CTCCATCACATCTCCAATGGGAGTAACACTCCATCTTCTTCGGAAGGTGGCCCAGATGCTGTCATTATTGGAATGACCAAGATCCCTGTC
ATTGAAAATCCCCAGTACTTTGGCATCACCAACAGTCAGCTCAAGCCAGACACATTTGTTCAGCACATCAAGCGACATAACATTGTTCTG
AAAAGGGAGCTAGGCGAAGGAGCCTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGACAAGATCTTGGTGGCA
GTGAAGACCCTGAAGGATGCCAGTGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATC
GTCAAGTTCTATGGCGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTCAACAAGTTCCTCAGG
GCACACGGCCCTGATGCCGTGCTGATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCATATAGCCCAGCAGATC
GCCGCGGGCATGGTCTACCTGGCGTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGGGAGAACTTGCTGGTG
AAAATCGGGGACTTTGGGATGTCCCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTGCCCATTCGCTGGATG
CCTCCAGAGAGCATCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAGATTTTCACCTATGGC
AAACAGCCCTGGTACCAGCTGTCAAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCCCGCACGTGCCCCCAG
GAGGTGTATGAGCTGATGCTGGGGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACCCTCCTTCAGAACTTG
GCCAAGGCATCTCCGGTCTACCTGGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACTCCTCAGACGGGCTGA
GAGGATGAACATCTTTTAACTGCCGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAAGACTCCGAGAAGCTC
TCGAGGGAAGCAGTGTGTACTTCTTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCTTTCCATCTCCCTTGG
TTGTTCCTTTTTCTTTTTTTAAATTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTTCTTTTGAATCAATCT
GGCTTCTGCATTACTATTAACTCTGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCCAGTTTGCCCACCACA
ACTAACAATGCCTTGTTGTATTCCTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTTTGTCACTTCTGCTGT
ACAGATATCGAGAGTTTCTATGGATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGCTTAAGCCTGTGTATA
AAAAAGAAAACTTGTGTTCAATCTGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATTATGAACCGCAATATG
GGAGGAACAAAGACAACCACTGGGATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGGGAAGAATGTATTCGG
CACCTTCCCCTGAGGACCTTTCTGAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCATCACCAGAAATGATAGC
GTGCAGTAGAGAGCAAAGATGGCTTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTCGTAGGTTGTGATGAT
AGCACTGGTTTGTTTCTCAAGCGCTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGATTCATGTCCAGAGCTCATTTCGGG
GTCAGGTGGGAAAGCCAAGAACTTGGAAAAGATAAGACAAGCTATAAATTCGGAGGCAAGTTTCTTTTACAATGAACTTTTCAGATCTCA
CTTCCCTCCGACCCCTAACTTCCATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTGCATGGTCTTCGTCGATTAATACCTTGTG
TGCAGACACTACTGCTCCAGACGTCGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACTTATACAATTAGGGGAAGCTAATG
GAGTTTATTAGCTGAGTATCAATGTCTCTGCGTTGTACGGTGGTGATGGGTTTTAATGAATATGGACCCTGAAGCCTGGAAATCCTCATC
CACGTCGAACCCACAGGACTGTGGGAAGGGCAGAATCAATCCCTAAGGGAAAGGAAACCTCACCCTGAGGGCATCACATGCACTCATGTT
CAGTGTACACAGGTCAAGTCCCTTGCTCTGGGCTCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTACTCCATTGTCAGTATGCTGTTTTT
GTTTCCTTCACTCCATTCAAAAAGTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCTGTGCCCAGACCAAGCACTGGAAGTGT
GCTTCTAGGCATAGTCATTGGTTTTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATTTGAATGGTCAGATATACCAAGAA
AGAAAAATATTTCTGTTCCTCAAGAAAACTTGCTACCCTCTGTGAGGGGAATTTTGCTAAACTTGACATCTTTATAACATGAGCCAGATT
GAAAGGGAGTGATTTTCATTCATCTTAGGTCATGTTATTTCATATTTGTTTCTGAAGGTGCGATAGCTCTGTTTTAGGTTTTGCTTGCGC
CTGTTAATTACTGGAACACCTTATTTTTCATTAAAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAAGTGCAAATTAACAGAACAAAAGG
AAATCCAGTAGCAACTGCAGTCAAGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAAGTTATATGCTGGCCTATGAGAGATGAGA

>In-frame_ENST00000415680_ENST00000376213_TCGA-55-8091-01A_TRIM24_chr7_138258387_+_NTRK2_chr9_87482158_length(amino acids)=994AA_start in transcript=114_stop in transcript=3098
MEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLM
LPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECV
EWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVII
DTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVM
HFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCDPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSG
LSSNQLSKFPTQISLAQLRLQHMQQQQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSG
QGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQSPNSS
VPSPGLAGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGA
FGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVL
MAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYR
KFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TRIM24-NTRK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneNTRK2chr7:138258387chr9:87482158ENST00000359847012455_4660478.0MAPK8IP3/JIP3
TgeneNTRK2chr7:138258387chr9:87482158ENST00000395866012455_4660322.0MAPK8IP3/JIP3
TgeneNTRK2chr7:138258387chr9:87482158ENST00000395882013455_4660478.0MAPK8IP3/JIP3


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTRIM24chr7:138258387chr9:87482158ENST00000343526+1219834_840671.33333333333341051.0histone H3 that is not methylated at 'Lys-4' (H3K4me0)
HgeneTRIM24chr7:138258387chr9:87482158ENST00000415680+1219834_840637.33333333333341017.0histone H3 that is not methylated at 'Lys-4' (H3K4me0)
TgeneNTRK2chr7:138258387chr9:87482158ENST000002771201219455_466481.3333333333333839.0MAPK8IP3/JIP3
TgeneNTRK2chr7:138258387chr9:87482158ENST000003040531215455_466481.3333333333333554.0MAPK8IP3/JIP3
TgeneNTRK2chr7:138258387chr9:87482158ENST000003231151017455_466465.3333333333333823.0MAPK8IP3/JIP3
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762081114455_466465.3333333333333538.0MAPK8IP3/JIP3
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762131320455_466465.3333333333333823.0MAPK8IP3/JIP3
TgeneNTRK2chr7:138258387chr9:87482158ENST000003762141421455_466481.3333333333333839.0MAPK8IP3/JIP3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRIM24-NTRK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNTRK2Q16620DB00321AmitriptylineAgonistSmall moleculeApproved
TgeneNTRK2Q16620DB00321AmitriptylineAgonistSmall moleculeApproved
TgeneNTRK2Q16620DB11823EsketamineSmall moleculeApproved|Investigational
TgeneNTRK2Q16620DB11823EsketamineSmall moleculeApproved|Investigational
TgeneNTRK2Q16620DB11986EntrectinibInhibitorSmall moleculeApproved|Investigational
TgeneNTRK2Q16620DB11986EntrectinibInhibitorSmall moleculeApproved|Investigational
TgeneNTRK2Q16620DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneNTRK2Q16620DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneNTRK2Q16620DB14723LarotrectinibInhibitorSmall moleculeApproved|Investigational
TgeneNTRK2Q16620DB14723LarotrectinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for TRIM24-NTRK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIM24C0238463Papillary thyroid carcinoma2ORPHANET
HgeneTRIM24C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneTRIM24C2239176Liver carcinoma1CTD_human
HgeneTRIM24C3658266Prostatic Cancer, Castration-Resistant1CTD_human
HgeneTRIM24C3658267Prostatic Neoplasms, Castration-Resistant1CTD_human
TgeneNTRK2C0011570Mental Depression5PSYGENET
TgeneNTRK2C0011581Depressive disorder5PSYGENET
TgeneNTRK2C0041696Unipolar Depression5PSYGENET
TgeneNTRK2C0525045Mood Disorders5PSYGENET
TgeneNTRK2C1269683Major Depressive Disorder5PSYGENET
TgeneNTRK2C3151303Obesity, Hyperphagia, and Developmental Delay4CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneNTRK2C0005586Bipolar Disorder3CTD_human;PSYGENET
TgeneNTRK2C4693367EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 583GENOMICS_ENGLAND;UNIPROT
TgeneNTRK2C0009171Cocaine Abuse2CTD_human
TgeneNTRK2C0036341Schizophrenia2PSYGENET
TgeneNTRK2C0038220Status Epilepticus2CTD_human
TgeneNTRK2C0236736Cocaine-Related Disorders2CTD_human
TgeneNTRK2C0270823Petit mal status2CTD_human
TgeneNTRK2C0311335Grand Mal Status Epilepticus2CTD_human
TgeneNTRK2C0393734Complex Partial Status Epilepticus2CTD_human
TgeneNTRK2C0600427Cocaine Dependence2CTD_human
TgeneNTRK2C0751217Hyperkinesia, Generalized2CTD_human
TgeneNTRK2C0751522Status Epilepticus, Subclinical2CTD_human
TgeneNTRK2C0751523Non-Convulsive Status Epilepticus2CTD_human
TgeneNTRK2C0751524Simple Partial Status Epilepticus2CTD_human
TgeneNTRK2C3887506Hyperkinesia2CTD_human
TgeneNTRK2C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneNTRK2C0004114Astrocytoma1CTD_human
TgeneNTRK2C0004352Autistic Disorder1CTD_human
TgeneNTRK2C0005587Depression, Bipolar1CTD_human
TgeneNTRK2C0008073Developmental Disabilities1CTD_human
TgeneNTRK2C0013415Dysthymic Disorder1PSYGENET
TgeneNTRK2C0017638Glioma1CTD_human
TgeneNTRK2C0020505Hyperphagia1CTD_human
TgeneNTRK2C0024713Manic Disorder1CTD_human
TgeneNTRK2C0027819Neuroblastoma1CTD_human
TgeneNTRK2C0028754Obesity1CTD_human
TgeneNTRK2C0036349Paranoid Schizophrenia1PSYGENET
TgeneNTRK2C0037769West Syndrome1ORPHANET
TgeneNTRK2C0085996Child Development Deviations1CTD_human
TgeneNTRK2C0085997Child Development Disorders, Specific1CTD_human
TgeneNTRK2C0205768Subependymal Giant Cell Astrocytoma1CTD_human
TgeneNTRK2C0259783mixed gliomas1CTD_human
TgeneNTRK2C0280783Juvenile Pilocytic Astrocytoma1CTD_human
TgeneNTRK2C0280785Diffuse Astrocytoma1CTD_human
TgeneNTRK2C0334579Anaplastic astrocytoma1CTD_human
TgeneNTRK2C0334580Protoplasmic astrocytoma1CTD_human
TgeneNTRK2C0334581Gemistocytic astrocytoma1CTD_human
TgeneNTRK2C0334582Fibrillary Astrocytoma1CTD_human
TgeneNTRK2C0334583Pilocytic Astrocytoma1CTD_human
TgeneNTRK2C0338070Childhood Cerebral Astrocytoma1CTD_human
TgeneNTRK2C0338831Manic1CTD_human
TgeneNTRK2C0547065Mixed oligoastrocytoma1CTD_human
TgeneNTRK2C0555198Malignant Glioma1CTD_human
TgeneNTRK2C0678807prenatal alcohol exposure1PSYGENET
TgeneNTRK2C0750935Cerebral Astrocytoma1CTD_human
TgeneNTRK2C0750936Intracranial Astrocytoma1CTD_human
TgeneNTRK2C0752347Lewy Body Disease1CTD_human
TgeneNTRK2C1519086Pilomyxoid astrocytoma1ORPHANET
TgeneNTRK2C1704230Grade I Astrocytoma1CTD_human
TgeneNTRK2C3146244Alcohol Related Birth Defect1PSYGENET