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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TRIM27-RET (FusionGDB2 ID:93394)

Fusion Gene Summary for TRIM27-RET

Fusion gene summary

Fusion gene information	Fusion gene name: TRIM27-RET
	Fusion gene ID: 93394
		Hgene	Tgene
	Gene symbol	TRIM27	RET
	Gene ID	5987	5979
	Gene name	tripartite motif containing 27	ret proto-oncogene
	Synonyms	RFP\|RNF76	CDHF12\|CDHR16\|HSCR1\|MEN2A\|MEN2B\|MTC1\|PTC\|RET-ELE1
	Cytomap	6p22.1	10q11.21
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein RFPRFP transforming proteinRING finger protein 76RING-type E3 ubiquitin transferase TRIM27ret finger proteintripartite motif protein TRIM27tripartite motif-containing protein 27	proto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary
	Modification date	20200327	20200322
	UniProtAcc	.	RTL1
	Ensembl transtripts involved in fusion gene	ENST00000377194, ENST00000377199, ENST00000498117, ENST00000459807, ENST00000412687, ENST00000437160, ENST00000427689, ENST00000435528, ENST00000485666, ENST00000468364, ENST00000455861, ENST00000417660, ENST00000400720, ENST00000495323, ENST00000491158, ENST00000437415, ENST00000468047, ENST00000431123, ENST00000452265,	ENST00000355710, ENST00000340058,
Fusion gene scores	* DoF score	5 X 9 X 7=315	32 X 31 X 11=10912
	# samples	9	48
	** MAII score	log2(9/315*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(48/10912*10)=-4.50673733341565 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TRIM27 [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TRIM27(28887789)-RET(43612032), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TRIM27	GO:0000122	negative regulation of transcription by RNA polymerase II	10976108
Hgene	TRIM27	GO:0006469	negative regulation of protein kinase activity	22128329
Hgene	TRIM27	GO:0032897	negative regulation of viral transcription	18248090
Hgene	TRIM27	GO:0034314	Arp2/3 complex-mediated actin nucleation	23452853
Hgene	TRIM27	GO:0042147	retrograde transport, endosome to Golgi	23452853
Hgene	TRIM27	GO:0045087	innate immune response	18248090
Hgene	TRIM27	GO:0045814	negative regulation of gene expression, epigenetic	10976108
Hgene	TRIM27	GO:0051091	positive regulation of DNA-binding transcription factor activity	23077300
Tgene	RET	GO:0030155	regulation of cell adhesion	21357690
Tgene	RET	GO:0030335	positive regulation of cell migration	20702524
Tgene	RET	GO:0033619	membrane protein proteolysis	21357690
Tgene	RET	GO:0033630	positive regulation of cell adhesion mediated by integrin	20702524
Tgene	RET	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway	28953886
Tgene	RET	GO:0043410	positive regulation of MAPK cascade	28846099

Fusion gene breakpoints across TRIM27 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	THCA	TCGA-CE-A481-01A	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
ChimerDB4	THCA	TCGA-CE-A481	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
ChimerDB4	THCA	TCGA-CE-A481-01A	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
ChimerDB4	THCA	TCGA-CE-A481-01A	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
ChimerDB4	adenocarcinoma	M16029	TRIM27	chr6	232335		RET	chr10	43608999
ChiTaRS5.0	N/A	M16029	TRIM27	chr6	28875012	-	RET	chr10	43608999	+

Top

Fusion Gene ORF analysis for TRIM27-RET

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000377194	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
In-frame	ENST00000377194	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
In-frame	ENST00000377199	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
In-frame	ENST00000377199	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
5UTR-3CDS	ENST00000498117	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
5UTR-3CDS	ENST00000498117	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000459807	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000459807	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000412687	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000412687	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000437160	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000437160	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000427689	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000427689	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000435528	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000435528	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000485666	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000485666	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000468364	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000468364	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000455861	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000455861	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000417660	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000417660	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000400720	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000400720	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000495323	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000495323	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000491158	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000491158	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000437415	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000437415	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000468047	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000468047	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000431123	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000431123	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000452265	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
intron-3CDS	ENST00000452265	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+
In-frame	ENST00000377194	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
In-frame	ENST00000377194	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
In-frame	ENST00000377199	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
In-frame	ENST00000377199	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
5UTR-3CDS	ENST00000498117	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
5UTR-3CDS	ENST00000498117	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000459807	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000459807	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000412687	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000412687	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000437160	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000437160	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000427689	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000427689	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000435528	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000435528	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000485666	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000485666	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000468364	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000468364	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000455861	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000455861	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000417660	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000417660	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000400720	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000400720	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000495323	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000495323	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000491158	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000491158	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000437415	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000437415	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000468047	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000468047	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000431123	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000431123	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000452265	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000452265	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+
intron-3CDS	ENST00000377194	ENST00000355710	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000377194	ENST00000340058	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000377199	ENST00000355710	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000377199	ENST00000340058	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000498117	ENST00000355710	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000498117	ENST00000340058	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000459807	ENST00000355710	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000459807	ENST00000340058	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000412687	ENST00000355710	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000412687	ENST00000340058	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000437160	ENST00000355710	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000437160	ENST00000340058	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000427689	ENST00000355710	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000427689	ENST00000340058	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000435528	ENST00000355710	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000435528	ENST00000340058	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000485666	ENST00000355710	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000485666	ENST00000340058	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000468364	ENST00000355710	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000468364	ENST00000340058	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000455861	ENST00000355710	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000455861	ENST00000340058	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000417660	ENST00000355710	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000417660	ENST00000340058	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000400720	ENST00000355710	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000400720	ENST00000340058	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000495323	ENST00000355710	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000495323	ENST00000340058	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000491158	ENST00000355710	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000491158	ENST00000340058	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000437415	ENST00000355710	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000437415	ENST00000340058	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000468047	ENST00000355710	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000468047	ENST00000340058	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000431123	ENST00000355710	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000431123	ENST00000340058	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000452265	ENST00000355710	TRIM27	chr6	232335		RET	chr10	43608999
intron-3CDS	ENST00000452265	ENST00000340058	TRIM27	chr6	232335		RET	chr10	43608999
In-frame	ENST00000377194	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
In-frame	ENST00000377194	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
In-frame	ENST00000377199	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
In-frame	ENST00000377199	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000498117	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000498117	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000459807	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000459807	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000412687	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000412687	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000437160	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000437160	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000427689	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000427689	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000435528	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000435528	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000485666	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000485666	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000468364	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000468364	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000455861	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000455861	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000417660	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000417660	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000400720	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000400720	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000495323	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000495323	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000491158	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000491158	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000437415	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000437415	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000468047	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000468047	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000431123	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000431123	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000452265	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+
intron-3CDS	ENST00000452265	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000377194	TRIM27	chr6	28887789	-	ENST00000355710	RET	chr10	43612032	+	4394	1103	212	2311	699
ENST00000377194	TRIM27	chr6	28887789	-	ENST00000340058	RET	chr10	43612032	+	2936	1103	212	2185	657
ENST00000377199	TRIM27	chr6	28887789	-	ENST00000355710	RET	chr10	43612032	+	4395	1104	213	2312	699
ENST00000377199	TRIM27	chr6	28887789	-	ENST00000340058	RET	chr10	43612032	+	2937	1104	213	2186	657
ENST00000377194	TRIM27	chr6	28887788	-	ENST00000355710	RET	chr10	43612031	+	4394	1103	212	2311	699
ENST00000377194	TRIM27	chr6	28887788	-	ENST00000340058	RET	chr10	43612031	+	2936	1103	212	2185	657
ENST00000377199	TRIM27	chr6	28887788	-	ENST00000355710	RET	chr10	43612031	+	4395	1104	213	2312	699
ENST00000377199	TRIM27	chr6	28887788	-	ENST00000340058	RET	chr10	43612031	+	2937	1104	213	2186	657
ENST00000377194	TRIM27	chr6	28875012	-	ENST00000355710	RET	chr10	43608999	+	4970	1302	212	2887	891
ENST00000377194	TRIM27	chr6	28875012	-	ENST00000340058	RET	chr10	43608999	+	3512	1302	212	2761	849
ENST00000377199	TRIM27	chr6	28875012	-	ENST00000355710	RET	chr10	43608999	+	4971	1303	213	2888	891
ENST00000377199	TRIM27	chr6	28875012	-	ENST00000340058	RET	chr10	43608999	+	3513	1303	213	2762	849

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000377194	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+	0.0036811	0.99631894
ENST00000377194	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+	0.015020659	0.98497933
ENST00000377199	ENST00000355710	TRIM27	chr6	28887789	-	RET	chr10	43612032	+	0.003663306	0.9963367
ENST00000377199	ENST00000340058	TRIM27	chr6	28887789	-	RET	chr10	43612032	+	0.014964578	0.9850354
ENST00000377194	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+	0.0036811	0.99631894
ENST00000377194	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+	0.015020659	0.98497933
ENST00000377199	ENST00000355710	TRIM27	chr6	28887788	-	RET	chr10	43612031	+	0.003663306	0.9963367
ENST00000377199	ENST00000340058	TRIM27	chr6	28887788	-	RET	chr10	43612031	+	0.014964578	0.9850354
ENST00000377194	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+	0.00204476	0.9979552
ENST00000377194	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+	0.010623794	0.9893762
ENST00000377199	ENST00000355710	TRIM27	chr6	28875012	-	RET	chr10	43608999	+	0.002036051	0.997964
ENST00000377199	ENST00000340058	TRIM27	chr6	28875012	-	RET	chr10	43608999	+	0.010573481	0.9894265

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Fusion Genomic Features for TRIM27-RET

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TRIM27	chr6	28875012	-	RET	chr10	43609003	+	0.91416335	0.08583669
TRIM27	chr6	28887788	-	RET	chr10	43612031	+	9.55E-09	1
TRIM27	chr6	28887788	-	RET	chr10	43612031	+	9.55E-09	1
TRIM27	chr6	28875012	-	RET	chr10	43609003	+	0.91416335	0.08583669
TRIM27	chr6	28887788	-	RET	chr10	43612031	+	9.55E-09	1
TRIM27	chr6	28887788	-	RET	chr10	43612031	+	9.55E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRIM27-RET

Go to
FGviewer for the breakpoints of chr6:28887789-chr10:43612032
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	RET RTL1
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	1358

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000377194

132_172

315.3333333333333

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000377194

282_311

315.3333333333333

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000377199

132_172

315.3333333333333

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000377199

282_311

315.3333333333333

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000377194

132_172

249.0

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000377199

132_172

249.0

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000377194

132_172

249.0

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000377199

132_172

249.0

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000377194

16_57

315.3333333333333

359.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000377194

96_127

315.3333333333333

359.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000377199

16_57

315.3333333333333

514.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000377199

96_127

315.3333333333333

514.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000377194

16_57

249.0

359.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000377194

96_127

249.0

359.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000377199

16_57

249.0

514.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000377199

96_127

249.0

514.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000377194

16_57

249.0

359.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000377194

96_127

249.0

359.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000377199

16_57

249.0

514.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000377199

96_127

249.0

514.0

Zinc finger

B box-type

Tgene

RET

chr6:28875012

chr10:43608999

ENST00000340058

724_1016

586.3333333333334

1073.0

Domain

Protein kinase

Tgene

RET

chr6:28875012

chr10:43608999

ENST00000355710

724_1016

586.3333333333334

1115.0

Domain

Protein kinase

Tgene

RET

chr6:28887788

chr10:43612031

ENST00000340058

724_1016

712.0

1073.0

Domain

Protein kinase

Tgene

RET

chr6:28887788

chr10:43612031

ENST00000355710

724_1016

712.0

1115.0

Domain

Protein kinase

Tgene

RET

chr6:28887789

chr10:43612032

ENST00000340058

724_1016

712.0

1073.0

Domain

Protein kinase

Tgene

RET

chr6:28887789

chr10:43612032

ENST00000355710

724_1016

712.0

1115.0

Domain

Protein kinase

Tgene

RET

chr6:28875012

chr10:43608999

ENST00000340058

730_738

586.3333333333334

1073.0

Nucleotide binding

ATP

Tgene

RET

chr6:28875012

chr10:43608999

ENST00000355710

730_738

586.3333333333334

1115.0

Nucleotide binding

ATP

Tgene

RET

chr6:28887788

chr10:43612031

ENST00000340058

730_738

712.0

1073.0

Nucleotide binding

ATP

Tgene

RET

chr6:28887788

chr10:43612031

ENST00000355710

730_738

712.0

1115.0

Nucleotide binding

ATP

Tgene

RET

chr6:28887789

chr10:43612032

ENST00000340058

730_738

712.0

1073.0

Nucleotide binding

ATP

Tgene

RET

chr6:28887789

chr10:43612032

ENST00000355710

730_738

712.0

1115.0

Nucleotide binding

ATP

Tgene

RET

chr6:28875012

chr10:43608999

ENST00000340058

805_807

586.3333333333334

1073.0

Region

Note=Inhibitors binding

Tgene

RET

chr6:28875012

chr10:43608999

ENST00000355710

805_807

586.3333333333334

1115.0

Region

Note=Inhibitors binding

Tgene

RET

chr6:28887788

chr10:43612031

ENST00000340058

805_807

712.0

1073.0

Region

Note=Inhibitors binding

Tgene

RET

chr6:28887788

chr10:43612031

ENST00000355710

805_807

712.0

1115.0

Region

Note=Inhibitors binding

Tgene

RET

chr6:28887789

chr10:43612032

ENST00000340058

805_807

712.0

1073.0

Region

Note=Inhibitors binding

Tgene

RET

chr6:28887789

chr10:43612032

ENST00000355710

805_807

712.0

1115.0

Region

Note=Inhibitors binding

Tgene

RET

chr6:28875012

chr10:43608999

ENST00000340058

658_1114

586.3333333333334

1073.0

Topological domain

Cytoplasmic

Tgene

RET

chr6:28875012

chr10:43608999

ENST00000355710

658_1114

586.3333333333334

1115.0

Topological domain

Cytoplasmic

Tgene

RET

chr6:28875012

chr10:43608999

ENST00000340058

636_657

586.3333333333334

1073.0

Transmembrane

Helical

Tgene

RET

chr6:28875012

chr10:43608999

ENST00000355710

636_657

586.3333333333334

1115.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000400720

132_172

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000400720

282_311

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000412687

132_172

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000412687

282_311

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000417660

132_172

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000417660

282_311

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000427689

132_172

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000427689

282_311

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000431123

132_172

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000431123

282_311

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000435528

132_172

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000435528

282_311

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000437160

132_172

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000437160

282_311

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000452265

132_172

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000452265

282_311

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000377194

282_311

249.0

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000377199

282_311

249.0

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000400720

132_172

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000400720

282_311

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000412687

132_172

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000412687

282_311

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000417660

132_172

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000417660

282_311

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000427689

132_172

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000427689

282_311

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000431123

132_172

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000431123

282_311

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000435528

132_172

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000435528

282_311

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000437160

132_172

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000437160

282_311

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000452265

132_172

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000452265

282_311

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000377194

282_311

249.0

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000377199

282_311

249.0

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000400720

132_172

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000400720

282_311

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000412687

132_172

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000412687

282_311

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000417660

132_172

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000417660

282_311

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000427689

132_172

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000427689

282_311

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000431123

132_172

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000431123

282_311

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000435528

132_172

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000435528

282_311

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000437160

132_172

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000437160

282_311

514.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000452265

132_172

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000452265

282_311

359.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000377194

298_492

315.3333333333333

359.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000377199

298_492

315.3333333333333

514.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000400720

298_492

514.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000412687

298_492

359.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000417660

298_492

359.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000427689

298_492

359.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000431123

298_492

514.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000435528

298_492

514.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000437160

298_492

514.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000452265

298_492

359.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000377194

298_492

249.0

359.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000377199

298_492

249.0

514.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000400720

298_492

514.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000412687

298_492

359.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000417660

298_492

359.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000427689

298_492

359.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000431123

298_492

514.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000435528

298_492

514.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000437160

298_492

514.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000452265

298_492

359.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000377194

298_492

249.0

359.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000377199

298_492

249.0

514.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000400720

298_492

514.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000412687

298_492

359.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000417660

298_492

359.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000427689

298_492

359.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000431123

298_492

514.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000435528

298_492

514.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000437160

298_492

514.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000452265

298_492

359.0

Domain

B30.2/SPRY

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000400720

16_57

514.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000400720

96_127

514.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000412687

16_57

359.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000412687

96_127

359.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000417660

16_57

359.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000417660

96_127

359.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000427689

16_57

359.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000427689

96_127

359.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000431123

16_57

514.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000431123

96_127

514.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000435528

16_57

514.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000435528

96_127

514.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000437160

16_57

514.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000437160

96_127

514.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000452265

16_57

359.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28875012

chr10:43608999

ENST00000452265

96_127

359.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000400720

16_57

514.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000400720

96_127

514.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000412687

16_57

359.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000412687

96_127

359.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000417660

16_57

359.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000417660

96_127

359.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000427689

16_57

359.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000427689

96_127

359.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000431123

16_57

514.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000431123

96_127

514.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000435528

16_57

514.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000435528

96_127

514.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000437160

16_57

514.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000437160

96_127

514.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000452265

16_57

359.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28887788

chr10:43612031

ENST00000452265

96_127

359.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000400720

16_57

514.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000400720

96_127

514.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000412687

16_57

359.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000412687

96_127

359.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000417660

16_57

359.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000417660

96_127

359.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000427689

16_57

359.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000427689

96_127

359.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000431123

16_57

514.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000431123

96_127

514.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000435528

16_57

514.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000435528

96_127

514.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000437160

16_57

514.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000437160

96_127

514.0

Zinc finger

B box-type

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000452265

16_57

359.0

Zinc finger

RING-type

Hgene

TRIM27

chr6:28887789

chr10:43612032

ENST00000452265

96_127

359.0

Zinc finger

B box-type

Tgene

RET

chr6:28875012

chr10:43608999

ENST00000340058

168_272

586.3333333333334

1073.0

Domain

Cadherin

Tgene

RET

chr6:28875012

chr10:43608999

ENST00000355710

168_272

586.3333333333334

1115.0

Domain

Cadherin

Tgene

RET

chr6:28887788

chr10:43612031

ENST00000340058

168_272

712.0

1073.0

Domain

Cadherin

Tgene

RET

chr6:28887788

chr10:43612031

ENST00000355710

168_272

712.0

1115.0

Domain

Cadherin

Tgene

RET

chr6:28887789

chr10:43612032

ENST00000340058

168_272

712.0

1073.0

Domain

Cadherin

Tgene

RET

chr6:28887789

chr10:43612032

ENST00000355710

168_272

712.0

1115.0

Domain

Cadherin

Tgene

RET

chr6:28875012

chr10:43608999

ENST00000340058

29_635

586.3333333333334

1073.0

Topological domain

Extracellular

Tgene

RET

chr6:28875012

chr10:43608999

ENST00000355710

29_635

586.3333333333334

1115.0

Topological domain

Extracellular

Tgene

RET

chr6:28887788

chr10:43612031

ENST00000340058

29_635

712.0

1073.0

Topological domain

Extracellular

Tgene

RET

chr6:28887788

chr10:43612031

ENST00000340058

658_1114

712.0

1073.0

Topological domain

Cytoplasmic

Tgene

RET

chr6:28887788

chr10:43612031

ENST00000355710

29_635

712.0

1115.0

Topological domain

Extracellular

Tgene

RET

chr6:28887788

chr10:43612031

ENST00000355710

658_1114

712.0

1115.0

Topological domain

Cytoplasmic

Tgene

RET

chr6:28887789

chr10:43612032

ENST00000340058

29_635

712.0

1073.0

Topological domain

Extracellular

Tgene

RET

chr6:28887789

chr10:43612032

ENST00000340058

658_1114

712.0

1073.0

Topological domain

Cytoplasmic

Tgene

RET

chr6:28887789

chr10:43612032

ENST00000355710

29_635

712.0

1115.0

Topological domain

Extracellular

Tgene

RET

chr6:28887789

chr10:43612032

ENST00000355710

658_1114

712.0

1115.0

Topological domain

Cytoplasmic

Tgene

RET

chr6:28887788

chr10:43612031

ENST00000340058

636_657

712.0

1073.0

Transmembrane

Helical

Tgene

RET

chr6:28887788

chr10:43612031

ENST00000355710

636_657

712.0

1115.0

Transmembrane

Helical

Tgene

RET

chr6:28887789

chr10:43612032

ENST00000340058

636_657

712.0

1073.0

Transmembrane

Helical

Tgene

RET

chr6:28887789

chr10:43612032

ENST00000355710

636_657

712.0

1115.0

Transmembrane

Helical

Top

Fusion Gene Sequence for TRIM27-RET

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000377194_ENST00000355710_TCGA-CE-A481-01A_TRIM27_chr6_28887789_-_RET_chr10_43612032_length(transcript)=4394nt_BP=1103nt
TTTACGCTGCCGCCGGCATCCGCTCGGACGCGGCCACGTTGTCTTGCGCGCTTTGCCCGCCTGGCCCTGGGACTCTGACCCTCGGCTACC
CTTTCCTGCCCCACTAGCGTGGCCGCGAGCCTCGGTGAGCCGGCCGTATTCCCGCTCTCGCTTAGGGGGCACAGGCGCAGGCATCGGCCC
GGCCACTCCAAGCCTTCGGTGCGCGGGCGCGTCTGGGATACGGGCCCGGGAGGCGCCGCCCTCCGTCCGCCCGGTGCCTCTCAGGAACAG
CGAACCGGAGAGAGCGCCGGAGAGTTGGGCTCAGTGCAGAGCTCGGCGCCGGGGCCCATGCCCGTGCGCCCCCGCAGGCCGGCGCCATGG
CCTCCGGGAGTGTGGCCGAGTGCCTGCAGCAGGAGACCACCTGCCCCGTGTGCCTGCAGTACTTCGCAGAGCCCATGATGCTCGACTGCG
GCCATAACATCTGTTGCGCGTGCCTCGCCCGCTGCTGGGGCACGGCAGAGACTAACGTGTCGTGCCCGCAGTGCCGGGAGACCTTCCCGC
AGAGGCACATGCGGCCCAACCGGCACCTGGCCAACGTGACCCAACTGGTAAAGCAGCTGCGCACCGAGCGGCCGTCGGGGCCCGGCGGCG
AGATGGGCGTGTGCGAGAAGCACCGCGAGCCCCTGAAGCTGTACTGCGAGGAGGACCAGATGCCCATCTGCGTGGTGTGCGACCGCTCCC
GCGAGCACCGCGGCCACAGCGTGCTGCCGCTCGAGGAGGCGGTGGAGGGCTTCAAGGAGCAAATCCAGAACCAGCTCGACCATTTAAAAA
GAGTGAAAGATTTAAAGAAGAGACGTCGGGCCCAGGGGGAACAGGCACGAGCTGAACTCTTGAGCCTAACCCAGATGGAGAGGGAGAAGA
TTGTTTGGGAGTTTGAGCAGCTGTATCACTCCTTAAAGGAGCATGAGTATCGCCTCCTGGCCCGCCTTGAGGAGCTAGACTTGGCCATCT
ACAATAGCATCAATGGTGCCATCACCCAGTTCTCTTGCAACATCTCCCACCTCAGCAGCCTGATCGCTCAGCTAGAAGAGAAGCAGCAGC
AGCCCACCAGGGAGCTCCTGCAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAAT
TTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCT
CCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCA
GCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTG
GCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTG
CCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGG
GGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAG
TTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCG
TGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACA
ACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACC
TGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAG
AGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGT
CAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTG
TATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCA
CAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTG
GCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACAC
CGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACC
ACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCG
CCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAG
AATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTC
AGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCC
TAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCC
CGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCC
CAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCA
GTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCT
AGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTA
TAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGAC
CATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGG
GAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGAC
TTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTG
TGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACA
CGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTT
CAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATT
GCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCC
TTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAA
GTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACC

>In-frame_ENST00000377194_ENST00000355710_TCGA-CE-A481-01A_TRIM27_chr6_28887789_-_RET_chr10_43612032_length(amino acids)=699AA_start in transcript=212_stop in transcript=2311
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE
FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL
AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI
PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN

--------------------------------------------------------------
>In-frame_ENST00000377194_ENST00000340058_TCGA-CE-A481-01A_TRIM27_chr6_28887789_-_RET_chr10_43612032_length(transcript)=2936nt_BP=1103nt
TTTACGCTGCCGCCGGCATCCGCTCGGACGCGGCCACGTTGTCTTGCGCGCTTTGCCCGCCTGGCCCTGGGACTCTGACCCTCGGCTACC
CTTTCCTGCCCCACTAGCGTGGCCGCGAGCCTCGGTGAGCCGGCCGTATTCCCGCTCTCGCTTAGGGGGCACAGGCGCAGGCATCGGCCC
GGCCACTCCAAGCCTTCGGTGCGCGGGCGCGTCTGGGATACGGGCCCGGGAGGCGCCGCCCTCCGTCCGCCCGGTGCCTCTCAGGAACAG
CGAACCGGAGAGAGCGCCGGAGAGTTGGGCTCAGTGCAGAGCTCGGCGCCGGGGCCCATGCCCGTGCGCCCCCGCAGGCCGGCGCCATGG
CCTCCGGGAGTGTGGCCGAGTGCCTGCAGCAGGAGACCACCTGCCCCGTGTGCCTGCAGTACTTCGCAGAGCCCATGATGCTCGACTGCG
GCCATAACATCTGTTGCGCGTGCCTCGCCCGCTGCTGGGGCACGGCAGAGACTAACGTGTCGTGCCCGCAGTGCCGGGAGACCTTCCCGC
AGAGGCACATGCGGCCCAACCGGCACCTGGCCAACGTGACCCAACTGGTAAAGCAGCTGCGCACCGAGCGGCCGTCGGGGCCCGGCGGCG
AGATGGGCGTGTGCGAGAAGCACCGCGAGCCCCTGAAGCTGTACTGCGAGGAGGACCAGATGCCCATCTGCGTGGTGTGCGACCGCTCCC
GCGAGCACCGCGGCCACAGCGTGCTGCCGCTCGAGGAGGCGGTGGAGGGCTTCAAGGAGCAAATCCAGAACCAGCTCGACCATTTAAAAA
GAGTGAAAGATTTAAAGAAGAGACGTCGGGCCCAGGGGGAACAGGCACGAGCTGAACTCTTGAGCCTAACCCAGATGGAGAGGGAGAAGA
TTGTTTGGGAGTTTGAGCAGCTGTATCACTCCTTAAAGGAGCATGAGTATCGCCTCCTGGCCCGCCTTGAGGAGCTAGACTTGGCCATCT
ACAATAGCATCAATGGTGCCATCACCCAGTTCTCTTGCAACATCTCCCACCTCAGCAGCCTGATCGCTCAGCTAGAAGAGAAGCAGCAGC
AGCCCACCAGGGAGCTCCTGCAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAAT
TTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCT
CCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCA
GCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTG
GCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTG
CCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGG
GGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAG
TTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCG
TGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACA
ACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACC
TGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAG
AGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAA
TTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTG
AACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTT
TTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCA
GGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACAA
ATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGG
GCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCA
GGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGAC
GGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGT

>In-frame_ENST00000377194_ENST00000340058_TCGA-CE-A481-01A_TRIM27_chr6_28887789_-_RET_chr10_43612032_length(amino acids)=657AA_start in transcript=212_stop in transcript=2185
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE
FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL
AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI
PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN

--------------------------------------------------------------
>In-frame_ENST00000377199_ENST00000355710_TCGA-CE-A481-01A_TRIM27_chr6_28887789_-_RET_chr10_43612032_length(transcript)=4395nt_BP=1104nt
GTTTACGCTGCCGCCGGCATCCGCTCGGACGCGGCCACGTTGTCTTGCGCGCTTTGCCCGCCTGGCCCTGGGACTCTGACCCTCGGCTAC
CCTTTCCTGCCCCACTAGCGTGGCCGCGAGCCTCGGTGAGCCGGCCGTATTCCCGCTCTCGCTTAGGGGGCACAGGCGCAGGCATCGGCC
CGGCCACTCCAAGCCTTCGGTGCGCGGGCGCGTCTGGGATACGGGCCCGGGAGGCGCCGCCCTCCGTCCGCCCGGTGCCTCTCAGGAACA
GCGAACCGGAGAGAGCGCCGGAGAGTTGGGCTCAGTGCAGAGCTCGGCGCCGGGGCCCATGCCCGTGCGCCCCCGCAGGCCGGCGCCATG
GCCTCCGGGAGTGTGGCCGAGTGCCTGCAGCAGGAGACCACCTGCCCCGTGTGCCTGCAGTACTTCGCAGAGCCCATGATGCTCGACTGC
GGCCATAACATCTGTTGCGCGTGCCTCGCCCGCTGCTGGGGCACGGCAGAGACTAACGTGTCGTGCCCGCAGTGCCGGGAGACCTTCCCG
CAGAGGCACATGCGGCCCAACCGGCACCTGGCCAACGTGACCCAACTGGTAAAGCAGCTGCGCACCGAGCGGCCGTCGGGGCCCGGCGGC
GAGATGGGCGTGTGCGAGAAGCACCGCGAGCCCCTGAAGCTGTACTGCGAGGAGGACCAGATGCCCATCTGCGTGGTGTGCGACCGCTCC
CGCGAGCACCGCGGCCACAGCGTGCTGCCGCTCGAGGAGGCGGTGGAGGGCTTCAAGGAGCAAATCCAGAACCAGCTCGACCATTTAAAA
AGAGTGAAAGATTTAAAGAAGAGACGTCGGGCCCAGGGGGAACAGGCACGAGCTGAACTCTTGAGCCTAACCCAGATGGAGAGGGAGAAG
ATTGTTTGGGAGTTTGAGCAGCTGTATCACTCCTTAAAGGAGCATGAGTATCGCCTCCTGGCCCGCCTTGAGGAGCTAGACTTGGCCATC
TACAATAGCATCAATGGTGCCATCACCCAGTTCTCTTGCAACATCTCCCACCTCAGCAGCCTGATCGCTCAGCTAGAAGAGAAGCAGCAG
CAGCCCACCAGGGAGCTCCTGCAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAA
TTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCC
TCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGC
AGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCT
GGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTT
GCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAG
GGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCA
GTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATC
GTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGAC
AACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGAC
CTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCA
GAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATG
TCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGT
GTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTC
ACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGT
GGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACA
CCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGAC
CACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCC
GCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCA
GAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCT
CAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTC
CTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCC
CCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTC
CCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGC
AGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGC
TAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTT
ATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGA
CCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTG
GGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGA
CTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTT
GTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGAC
ACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTT
TCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAAT
TGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATC
CTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGA
AGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAAC

>In-frame_ENST00000377199_ENST00000355710_TCGA-CE-A481-01A_TRIM27_chr6_28887789_-_RET_chr10_43612032_length(amino acids)=699AA_start in transcript=213_stop in transcript=2312
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE
FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL
AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI
PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN

--------------------------------------------------------------
>In-frame_ENST00000377199_ENST00000340058_TCGA-CE-A481-01A_TRIM27_chr6_28887789_-_RET_chr10_43612032_length(transcript)=2937nt_BP=1104nt
GTTTACGCTGCCGCCGGCATCCGCTCGGACGCGGCCACGTTGTCTTGCGCGCTTTGCCCGCCTGGCCCTGGGACTCTGACCCTCGGCTAC
CCTTTCCTGCCCCACTAGCGTGGCCGCGAGCCTCGGTGAGCCGGCCGTATTCCCGCTCTCGCTTAGGGGGCACAGGCGCAGGCATCGGCC
CGGCCACTCCAAGCCTTCGGTGCGCGGGCGCGTCTGGGATACGGGCCCGGGAGGCGCCGCCCTCCGTCCGCCCGGTGCCTCTCAGGAACA
GCGAACCGGAGAGAGCGCCGGAGAGTTGGGCTCAGTGCAGAGCTCGGCGCCGGGGCCCATGCCCGTGCGCCCCCGCAGGCCGGCGCCATG
GCCTCCGGGAGTGTGGCCGAGTGCCTGCAGCAGGAGACCACCTGCCCCGTGTGCCTGCAGTACTTCGCAGAGCCCATGATGCTCGACTGC
GGCCATAACATCTGTTGCGCGTGCCTCGCCCGCTGCTGGGGCACGGCAGAGACTAACGTGTCGTGCCCGCAGTGCCGGGAGACCTTCCCG
CAGAGGCACATGCGGCCCAACCGGCACCTGGCCAACGTGACCCAACTGGTAAAGCAGCTGCGCACCGAGCGGCCGTCGGGGCCCGGCGGC
GAGATGGGCGTGTGCGAGAAGCACCGCGAGCCCCTGAAGCTGTACTGCGAGGAGGACCAGATGCCCATCTGCGTGGTGTGCGACCGCTCC
CGCGAGCACCGCGGCCACAGCGTGCTGCCGCTCGAGGAGGCGGTGGAGGGCTTCAAGGAGCAAATCCAGAACCAGCTCGACCATTTAAAA
AGAGTGAAAGATTTAAAGAAGAGACGTCGGGCCCAGGGGGAACAGGCACGAGCTGAACTCTTGAGCCTAACCCAGATGGAGAGGGAGAAG
ATTGTTTGGGAGTTTGAGCAGCTGTATCACTCCTTAAAGGAGCATGAGTATCGCCTCCTGGCCCGCCTTGAGGAGCTAGACTTGGCCATC
TACAATAGCATCAATGGTGCCATCACCCAGTTCTCTTGCAACATCTCCCACCTCAGCAGCCTGATCGCTCAGCTAGAAGAGAAGCAGCAG
CAGCCCACCAGGGAGCTCCTGCAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAA
TTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCC
TCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGC
AGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCT
GGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTT
GCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAG
GGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCA
GTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATC
GTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGAC
AACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGAC
CTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCA
GAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGA
ATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCT
GAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTT
TTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTC
AGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACA
AATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTG
GGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATC
AGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGA
CGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAG

>In-frame_ENST00000377199_ENST00000340058_TCGA-CE-A481-01A_TRIM27_chr6_28887789_-_RET_chr10_43612032_length(amino acids)=657AA_start in transcript=213_stop in transcript=2186
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE
FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL
AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI
PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN

--------------------------------------------------------------
>In-frame_ENST00000377194_ENST00000355710_TCGA-CE-A481_TRIM27_chr6_28887788_-_RET_chr10_43612031_length(transcript)=4394nt_BP=1103nt
TTTACGCTGCCGCCGGCATCCGCTCGGACGCGGCCACGTTGTCTTGCGCGCTTTGCCCGCCTGGCCCTGGGACTCTGACCCTCGGCTACC
CTTTCCTGCCCCACTAGCGTGGCCGCGAGCCTCGGTGAGCCGGCCGTATTCCCGCTCTCGCTTAGGGGGCACAGGCGCAGGCATCGGCCC
GGCCACTCCAAGCCTTCGGTGCGCGGGCGCGTCTGGGATACGGGCCCGGGAGGCGCCGCCCTCCGTCCGCCCGGTGCCTCTCAGGAACAG
CGAACCGGAGAGAGCGCCGGAGAGTTGGGCTCAGTGCAGAGCTCGGCGCCGGGGCCCATGCCCGTGCGCCCCCGCAGGCCGGCGCCATGG
CCTCCGGGAGTGTGGCCGAGTGCCTGCAGCAGGAGACCACCTGCCCCGTGTGCCTGCAGTACTTCGCAGAGCCCATGATGCTCGACTGCG
GCCATAACATCTGTTGCGCGTGCCTCGCCCGCTGCTGGGGCACGGCAGAGACTAACGTGTCGTGCCCGCAGTGCCGGGAGACCTTCCCGC
AGAGGCACATGCGGCCCAACCGGCACCTGGCCAACGTGACCCAACTGGTAAAGCAGCTGCGCACCGAGCGGCCGTCGGGGCCCGGCGGCG
AGATGGGCGTGTGCGAGAAGCACCGCGAGCCCCTGAAGCTGTACTGCGAGGAGGACCAGATGCCCATCTGCGTGGTGTGCGACCGCTCCC
GCGAGCACCGCGGCCACAGCGTGCTGCCGCTCGAGGAGGCGGTGGAGGGCTTCAAGGAGCAAATCCAGAACCAGCTCGACCATTTAAAAA
GAGTGAAAGATTTAAAGAAGAGACGTCGGGCCCAGGGGGAACAGGCACGAGCTGAACTCTTGAGCCTAACCCAGATGGAGAGGGAGAAGA
TTGTTTGGGAGTTTGAGCAGCTGTATCACTCCTTAAAGGAGCATGAGTATCGCCTCCTGGCCCGCCTTGAGGAGCTAGACTTGGCCATCT
ACAATAGCATCAATGGTGCCATCACCCAGTTCTCTTGCAACATCTCCCACCTCAGCAGCCTGATCGCTCAGCTAGAAGAGAAGCAGCAGC
AGCCCACCAGGGAGCTCCTGCAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAAT
TTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCT
CCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCA
GCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTG
GCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTG
CCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGG
GGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAG
TTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCG
TGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACA
ACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACC
TGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAG
AGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGT
CAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTG
TATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCA
CAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTG
GCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACAC
CGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACC
ACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCG
CCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAG
AATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTC
AGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCC
TAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCC
CGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCC
CAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCA
GTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCT
AGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTA
TAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGAC
CATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGG
GAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGAC
TTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTG
TGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACA
CGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTT
CAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATT
GCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCC
TTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAA
GTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACC

>In-frame_ENST00000377194_ENST00000355710_TCGA-CE-A481_TRIM27_chr6_28887788_-_RET_chr10_43612031_length(amino acids)=699AA_start in transcript=212_stop in transcript=2311
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE
FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL
AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI
PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN

--------------------------------------------------------------
>In-frame_ENST00000377194_ENST00000340058_TCGA-CE-A481_TRIM27_chr6_28887788_-_RET_chr10_43612031_length(transcript)=2936nt_BP=1103nt
TTTACGCTGCCGCCGGCATCCGCTCGGACGCGGCCACGTTGTCTTGCGCGCTTTGCCCGCCTGGCCCTGGGACTCTGACCCTCGGCTACC
CTTTCCTGCCCCACTAGCGTGGCCGCGAGCCTCGGTGAGCCGGCCGTATTCCCGCTCTCGCTTAGGGGGCACAGGCGCAGGCATCGGCCC
GGCCACTCCAAGCCTTCGGTGCGCGGGCGCGTCTGGGATACGGGCCCGGGAGGCGCCGCCCTCCGTCCGCCCGGTGCCTCTCAGGAACAG
CGAACCGGAGAGAGCGCCGGAGAGTTGGGCTCAGTGCAGAGCTCGGCGCCGGGGCCCATGCCCGTGCGCCCCCGCAGGCCGGCGCCATGG
CCTCCGGGAGTGTGGCCGAGTGCCTGCAGCAGGAGACCACCTGCCCCGTGTGCCTGCAGTACTTCGCAGAGCCCATGATGCTCGACTGCG
GCCATAACATCTGTTGCGCGTGCCTCGCCCGCTGCTGGGGCACGGCAGAGACTAACGTGTCGTGCCCGCAGTGCCGGGAGACCTTCCCGC
AGAGGCACATGCGGCCCAACCGGCACCTGGCCAACGTGACCCAACTGGTAAAGCAGCTGCGCACCGAGCGGCCGTCGGGGCCCGGCGGCG
AGATGGGCGTGTGCGAGAAGCACCGCGAGCCCCTGAAGCTGTACTGCGAGGAGGACCAGATGCCCATCTGCGTGGTGTGCGACCGCTCCC
GCGAGCACCGCGGCCACAGCGTGCTGCCGCTCGAGGAGGCGGTGGAGGGCTTCAAGGAGCAAATCCAGAACCAGCTCGACCATTTAAAAA
GAGTGAAAGATTTAAAGAAGAGACGTCGGGCCCAGGGGGAACAGGCACGAGCTGAACTCTTGAGCCTAACCCAGATGGAGAGGGAGAAGA
TTGTTTGGGAGTTTGAGCAGCTGTATCACTCCTTAAAGGAGCATGAGTATCGCCTCCTGGCCCGCCTTGAGGAGCTAGACTTGGCCATCT
ACAATAGCATCAATGGTGCCATCACCCAGTTCTCTTGCAACATCTCCCACCTCAGCAGCCTGATCGCTCAGCTAGAAGAGAAGCAGCAGC
AGCCCACCAGGGAGCTCCTGCAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAAT
TTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCT
CCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCA
GCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTG
GCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTG
CCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGG
GGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAG
TTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCG
TGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACA
ACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACC
TGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAG
AGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAA
TTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTG
AACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTT
TTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCA
GGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACAA
ATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGG
GCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCA
GGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGAC
GGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGT

>In-frame_ENST00000377194_ENST00000340058_TCGA-CE-A481_TRIM27_chr6_28887788_-_RET_chr10_43612031_length(amino acids)=657AA_start in transcript=212_stop in transcript=2185
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE
FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL
AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI
PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN

--------------------------------------------------------------
>In-frame_ENST00000377199_ENST00000355710_TCGA-CE-A481_TRIM27_chr6_28887788_-_RET_chr10_43612031_length(transcript)=4395nt_BP=1104nt
GTTTACGCTGCCGCCGGCATCCGCTCGGACGCGGCCACGTTGTCTTGCGCGCTTTGCCCGCCTGGCCCTGGGACTCTGACCCTCGGCTAC
CCTTTCCTGCCCCACTAGCGTGGCCGCGAGCCTCGGTGAGCCGGCCGTATTCCCGCTCTCGCTTAGGGGGCACAGGCGCAGGCATCGGCC
CGGCCACTCCAAGCCTTCGGTGCGCGGGCGCGTCTGGGATACGGGCCCGGGAGGCGCCGCCCTCCGTCCGCCCGGTGCCTCTCAGGAACA
GCGAACCGGAGAGAGCGCCGGAGAGTTGGGCTCAGTGCAGAGCTCGGCGCCGGGGCCCATGCCCGTGCGCCCCCGCAGGCCGGCGCCATG
GCCTCCGGGAGTGTGGCCGAGTGCCTGCAGCAGGAGACCACCTGCCCCGTGTGCCTGCAGTACTTCGCAGAGCCCATGATGCTCGACTGC
GGCCATAACATCTGTTGCGCGTGCCTCGCCCGCTGCTGGGGCACGGCAGAGACTAACGTGTCGTGCCCGCAGTGCCGGGAGACCTTCCCG
CAGAGGCACATGCGGCCCAACCGGCACCTGGCCAACGTGACCCAACTGGTAAAGCAGCTGCGCACCGAGCGGCCGTCGGGGCCCGGCGGC
GAGATGGGCGTGTGCGAGAAGCACCGCGAGCCCCTGAAGCTGTACTGCGAGGAGGACCAGATGCCCATCTGCGTGGTGTGCGACCGCTCC
CGCGAGCACCGCGGCCACAGCGTGCTGCCGCTCGAGGAGGCGGTGGAGGGCTTCAAGGAGCAAATCCAGAACCAGCTCGACCATTTAAAA
AGAGTGAAAGATTTAAAGAAGAGACGTCGGGCCCAGGGGGAACAGGCACGAGCTGAACTCTTGAGCCTAACCCAGATGGAGAGGGAGAAG
ATTGTTTGGGAGTTTGAGCAGCTGTATCACTCCTTAAAGGAGCATGAGTATCGCCTCCTGGCCCGCCTTGAGGAGCTAGACTTGGCCATC
TACAATAGCATCAATGGTGCCATCACCCAGTTCTCTTGCAACATCTCCCACCTCAGCAGCCTGATCGCTCAGCTAGAAGAGAAGCAGCAG
CAGCCCACCAGGGAGCTCCTGCAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAA
TTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCC
TCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGC
AGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCT
GGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTT
GCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAG
GGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCA
GTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATC
GTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGAC
AACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGAC
CTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCA
GAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATG
TCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGT
GTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTC
ACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGT
GGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACA
CCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGAC
CACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCC
GCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCA
GAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCT
CAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTC
CTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCC
CCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTC
CCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGC
AGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGC
TAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTT
ATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGA
CCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTG
GGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGA
CTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTT
GTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGAC
ACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTT
TCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAAT
TGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATC
CTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGA
AGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAAC

>In-frame_ENST00000377199_ENST00000355710_TCGA-CE-A481_TRIM27_chr6_28887788_-_RET_chr10_43612031_length(amino acids)=699AA_start in transcript=213_stop in transcript=2312
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE
FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL
AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI
PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN

--------------------------------------------------------------
>In-frame_ENST00000377199_ENST00000340058_TCGA-CE-A481_TRIM27_chr6_28887788_-_RET_chr10_43612031_length(transcript)=2937nt_BP=1104nt
GTTTACGCTGCCGCCGGCATCCGCTCGGACGCGGCCACGTTGTCTTGCGCGCTTTGCCCGCCTGGCCCTGGGACTCTGACCCTCGGCTAC
CCTTTCCTGCCCCACTAGCGTGGCCGCGAGCCTCGGTGAGCCGGCCGTATTCCCGCTCTCGCTTAGGGGGCACAGGCGCAGGCATCGGCC
CGGCCACTCCAAGCCTTCGGTGCGCGGGCGCGTCTGGGATACGGGCCCGGGAGGCGCCGCCCTCCGTCCGCCCGGTGCCTCTCAGGAACA
GCGAACCGGAGAGAGCGCCGGAGAGTTGGGCTCAGTGCAGAGCTCGGCGCCGGGGCCCATGCCCGTGCGCCCCCGCAGGCCGGCGCCATG
GCCTCCGGGAGTGTGGCCGAGTGCCTGCAGCAGGAGACCACCTGCCCCGTGTGCCTGCAGTACTTCGCAGAGCCCATGATGCTCGACTGC
GGCCATAACATCTGTTGCGCGTGCCTCGCCCGCTGCTGGGGCACGGCAGAGACTAACGTGTCGTGCCCGCAGTGCCGGGAGACCTTCCCG
CAGAGGCACATGCGGCCCAACCGGCACCTGGCCAACGTGACCCAACTGGTAAAGCAGCTGCGCACCGAGCGGCCGTCGGGGCCCGGCGGC
GAGATGGGCGTGTGCGAGAAGCACCGCGAGCCCCTGAAGCTGTACTGCGAGGAGGACCAGATGCCCATCTGCGTGGTGTGCGACCGCTCC
CGCGAGCACCGCGGCCACAGCGTGCTGCCGCTCGAGGAGGCGGTGGAGGGCTTCAAGGAGCAAATCCAGAACCAGCTCGACCATTTAAAA
AGAGTGAAAGATTTAAAGAAGAGACGTCGGGCCCAGGGGGAACAGGCACGAGCTGAACTCTTGAGCCTAACCCAGATGGAGAGGGAGAAG
ATTGTTTGGGAGTTTGAGCAGCTGTATCACTCCTTAAAGGAGCATGAGTATCGCCTCCTGGCCCGCCTTGAGGAGCTAGACTTGGCCATC
TACAATAGCATCAATGGTGCCATCACCCAGTTCTCTTGCAACATCTCCCACCTCAGCAGCCTGATCGCTCAGCTAGAAGAGAAGCAGCAG
CAGCCCACCAGGGAGCTCCTGCAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAA
TTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCC
TCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGC
AGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCT
GGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTT
GCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAG
GGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCA
GTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATC
GTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGAC
AACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGAC
CTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCA
GAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGA
ATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCT
GAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTT
TTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTC
AGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACA
AATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTG
GGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATC
AGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGA
CGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAG

>In-frame_ENST00000377199_ENST00000340058_TCGA-CE-A481_TRIM27_chr6_28887788_-_RET_chr10_43612031_length(amino acids)=657AA_start in transcript=213_stop in transcript=2186
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE
FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL
AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI
PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNN

--------------------------------------------------------------
>In-frame_ENST00000377194_ENST00000355710_M16029_TRIM27_chr6_28875012_-_RET_chr10_43608999_length(transcript)=4970nt_BP=1302nt
TTTACGCTGCCGCCGGCATCCGCTCGGACGCGGCCACGTTGTCTTGCGCGCTTTGCCCGCCTGGCCCTGGGACTCTGACCCTCGGCTACC
CTTTCCTGCCCCACTAGCGTGGCCGCGAGCCTCGGTGAGCCGGCCGTATTCCCGCTCTCGCTTAGGGGGCACAGGCGCAGGCATCGGCCC
GGCCACTCCAAGCCTTCGGTGCGCGGGCGCGTCTGGGATACGGGCCCGGGAGGCGCCGCCCTCCGTCCGCCCGGTGCCTCTCAGGAACAG
CGAACCGGAGAGAGCGCCGGAGAGTTGGGCTCAGTGCAGAGCTCGGCGCCGGGGCCCATGCCCGTGCGCCCCCGCAGGCCGGCGCCATGG
CCTCCGGGAGTGTGGCCGAGTGCCTGCAGCAGGAGACCACCTGCCCCGTGTGCCTGCAGTACTTCGCAGAGCCCATGATGCTCGACTGCG
GCCATAACATCTGTTGCGCGTGCCTCGCCCGCTGCTGGGGCACGGCAGAGACTAACGTGTCGTGCCCGCAGTGCCGGGAGACCTTCCCGC
AGAGGCACATGCGGCCCAACCGGCACCTGGCCAACGTGACCCAACTGGTAAAGCAGCTGCGCACCGAGCGGCCGTCGGGGCCCGGCGGCG
AGATGGGCGTGTGCGAGAAGCACCGCGAGCCCCTGAAGCTGTACTGCGAGGAGGACCAGATGCCCATCTGCGTGGTGTGCGACCGCTCCC
GCGAGCACCGCGGCCACAGCGTGCTGCCGCTCGAGGAGGCGGTGGAGGGCTTCAAGGAGCAAATCCAGAACCAGCTCGACCATTTAAAAA
GAGTGAAAGATTTAAAGAAGAGACGTCGGGCCCAGGGGGAACAGGCACGAGCTGAACTCTTGAGCCTAACCCAGATGGAGAGGGAGAAGA
TTGTTTGGGAGTTTGAGCAGCTGTATCACTCCTTAAAGGAGCATGAGTATCGCCTCCTGGCCCGCCTTGAGGAGCTAGACTTGGCCATCT
ACAATAGCATCAATGGTGCCATCACCCAGTTCTCTTGCAACATCTCCCACCTCAGCAGCCTGATCGCTCAGCTAGAAGAGAAGCAGCAGC
AGCCCACCAGGGAGCTCCTGCAGGACATTGGGGACACATTGAGCAGGGCTGAAAGAATCAGGATTCCTGAACCTTGGATCACACCTCCAG
ATTTGCAAGAGAAAATCCACATTTTTGCCCAAAAATGTCTATTCTTGACGGAGAGTCTAAAGCAGTTCACAGAAAAAATGCAGTCAGATA
TGGAGAAAATCCAAGAATTAAGAGAGGCTCAGTTATACTCAGGGGGCAGCATTGTTGGGGGACACGAGCCTGGGGAGCCCCGGGGGATTA
AAGCTGGCTATGGCACCTGCAACTGCTTCCCTGAGGAGGAGAAGTGCTTCTGCGAGCCCGAAGACATCCAGGATCCACTGTGCGACGAGC
TGTGCCGCACGGTGATCGCAGCCGCTGTCCTCTTCTCCTTCATCGTCTCGGTGCTGCTGTCTGCCTTCTGCATCCACTGCTACCACAAGT
TTGCCCACAAGCCACCCATCTCCTCAGCTGAGATGACCTTCCGGAGGCCCGCCCAGGCCTTCCCGGTCAGCTACTCCTCTTCCGGTGCCC
GCCGGCCCTCGCTGGACTCCATGGAGAACCAGGTCTCCGTGGATGCCTTCAAGATCCTGGAGGATCCAAAGTGGGAATTCCCTCGGAAGA
ACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACA
CCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCA
ACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGC
GGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATG
AGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATC
GGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGG
ATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTG
ATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACC
TTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGG
ACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTC
CATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCC
CTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCA
CTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTG
ATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAA
CGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGAT
AGCCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCA
GCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATGA
AATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAGTAG
GAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTG
GAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAGG
AAGACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGTGGT
ATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTGA
TGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCC
TGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGA
ATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATTA
CAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAAT
GCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGC
ACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAA
GAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTATATA
GGCATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACAC
ACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTCTTT
TACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCTC
AAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGAC
CCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATT
AGCTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTATTAA
AATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAATCAAGGTGACTAAGAAAATCAGTTGTGTAAA

>In-frame_ENST00000377194_ENST00000355710_M16029_TRIM27_chr6_28875012_-_RET_chr10_43608999_length(amino acids)=891AA_start in transcript=212_stop in transcript=2887
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQ
LYSGGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAE
MTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------
>In-frame_ENST00000377194_ENST00000340058_M16029_TRIM27_chr6_28875012_-_RET_chr10_43608999_length(transcript)=3512nt_BP=1302nt
TTTACGCTGCCGCCGGCATCCGCTCGGACGCGGCCACGTTGTCTTGCGCGCTTTGCCCGCCTGGCCCTGGGACTCTGACCCTCGGCTACC
CTTTCCTGCCCCACTAGCGTGGCCGCGAGCCTCGGTGAGCCGGCCGTATTCCCGCTCTCGCTTAGGGGGCACAGGCGCAGGCATCGGCCC
GGCCACTCCAAGCCTTCGGTGCGCGGGCGCGTCTGGGATACGGGCCCGGGAGGCGCCGCCCTCCGTCCGCCCGGTGCCTCTCAGGAACAG
CGAACCGGAGAGAGCGCCGGAGAGTTGGGCTCAGTGCAGAGCTCGGCGCCGGGGCCCATGCCCGTGCGCCCCCGCAGGCCGGCGCCATGG
CCTCCGGGAGTGTGGCCGAGTGCCTGCAGCAGGAGACCACCTGCCCCGTGTGCCTGCAGTACTTCGCAGAGCCCATGATGCTCGACTGCG
GCCATAACATCTGTTGCGCGTGCCTCGCCCGCTGCTGGGGCACGGCAGAGACTAACGTGTCGTGCCCGCAGTGCCGGGAGACCTTCCCGC
AGAGGCACATGCGGCCCAACCGGCACCTGGCCAACGTGACCCAACTGGTAAAGCAGCTGCGCACCGAGCGGCCGTCGGGGCCCGGCGGCG
AGATGGGCGTGTGCGAGAAGCACCGCGAGCCCCTGAAGCTGTACTGCGAGGAGGACCAGATGCCCATCTGCGTGGTGTGCGACCGCTCCC
GCGAGCACCGCGGCCACAGCGTGCTGCCGCTCGAGGAGGCGGTGGAGGGCTTCAAGGAGCAAATCCAGAACCAGCTCGACCATTTAAAAA
GAGTGAAAGATTTAAAGAAGAGACGTCGGGCCCAGGGGGAACAGGCACGAGCTGAACTCTTGAGCCTAACCCAGATGGAGAGGGAGAAGA
TTGTTTGGGAGTTTGAGCAGCTGTATCACTCCTTAAAGGAGCATGAGTATCGCCTCCTGGCCCGCCTTGAGGAGCTAGACTTGGCCATCT
ACAATAGCATCAATGGTGCCATCACCCAGTTCTCTTGCAACATCTCCCACCTCAGCAGCCTGATCGCTCAGCTAGAAGAGAAGCAGCAGC
AGCCCACCAGGGAGCTCCTGCAGGACATTGGGGACACATTGAGCAGGGCTGAAAGAATCAGGATTCCTGAACCTTGGATCACACCTCCAG
ATTTGCAAGAGAAAATCCACATTTTTGCCCAAAAATGTCTATTCTTGACGGAGAGTCTAAAGCAGTTCACAGAAAAAATGCAGTCAGATA
TGGAGAAAATCCAAGAATTAAGAGAGGCTCAGTTATACTCAGGGGGCAGCATTGTTGGGGGACACGAGCCTGGGGAGCCCCGGGGGATTA
AAGCTGGCTATGGCACCTGCAACTGCTTCCCTGAGGAGGAGAAGTGCTTCTGCGAGCCCGAAGACATCCAGGATCCACTGTGCGACGAGC
TGTGCCGCACGGTGATCGCAGCCGCTGTCCTCTTCTCCTTCATCGTCTCGGTGCTGCTGTCTGCCTTCTGCATCCACTGCTACCACAAGT
TTGCCCACAAGCCACCCATCTCCTCAGCTGAGATGACCTTCCGGAGGCCCGCCCAGGCCTTCCCGGTCAGCTACTCCTCTTCCGGTGCCC
GCCGGCCCTCGCTGGACTCCATGGAGAACCAGGTCTCCGTGGATGCCTTCAAGATCCTGGAGGATCCAAAGTGGGAATTCCCTCGGAAGA
ACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACA
CCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCA
ACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGC
GGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATG
AGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATC
GGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGG
ATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTG
ATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACC
TTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGG
ACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTC
CATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCC
CTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTC
CTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTTGCA
TCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTAGGA
TGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCAT
AGTACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCAC
TGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAA
GCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGC
TGTTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAA
CATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAAACTCCTTCTTTTGTCTTTGATTAAATACTAGAAAT

>In-frame_ENST00000377194_ENST00000340058_M16029_TRIM27_chr6_28875012_-_RET_chr10_43608999_length(amino acids)=849AA_start in transcript=212_stop in transcript=2761
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQ
LYSGGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAE
MTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------
>In-frame_ENST00000377199_ENST00000355710_M16029_TRIM27_chr6_28875012_-_RET_chr10_43608999_length(transcript)=4971nt_BP=1303nt
GTTTACGCTGCCGCCGGCATCCGCTCGGACGCGGCCACGTTGTCTTGCGCGCTTTGCCCGCCTGGCCCTGGGACTCTGACCCTCGGCTAC
CCTTTCCTGCCCCACTAGCGTGGCCGCGAGCCTCGGTGAGCCGGCCGTATTCCCGCTCTCGCTTAGGGGGCACAGGCGCAGGCATCGGCC
CGGCCACTCCAAGCCTTCGGTGCGCGGGCGCGTCTGGGATACGGGCCCGGGAGGCGCCGCCCTCCGTCCGCCCGGTGCCTCTCAGGAACA
GCGAACCGGAGAGAGCGCCGGAGAGTTGGGCTCAGTGCAGAGCTCGGCGCCGGGGCCCATGCCCGTGCGCCCCCGCAGGCCGGCGCCATG
GCCTCCGGGAGTGTGGCCGAGTGCCTGCAGCAGGAGACCACCTGCCCCGTGTGCCTGCAGTACTTCGCAGAGCCCATGATGCTCGACTGC
GGCCATAACATCTGTTGCGCGTGCCTCGCCCGCTGCTGGGGCACGGCAGAGACTAACGTGTCGTGCCCGCAGTGCCGGGAGACCTTCCCG
CAGAGGCACATGCGGCCCAACCGGCACCTGGCCAACGTGACCCAACTGGTAAAGCAGCTGCGCACCGAGCGGCCGTCGGGGCCCGGCGGC
GAGATGGGCGTGTGCGAGAAGCACCGCGAGCCCCTGAAGCTGTACTGCGAGGAGGACCAGATGCCCATCTGCGTGGTGTGCGACCGCTCC
CGCGAGCACCGCGGCCACAGCGTGCTGCCGCTCGAGGAGGCGGTGGAGGGCTTCAAGGAGCAAATCCAGAACCAGCTCGACCATTTAAAA
AGAGTGAAAGATTTAAAGAAGAGACGTCGGGCCCAGGGGGAACAGGCACGAGCTGAACTCTTGAGCCTAACCCAGATGGAGAGGGAGAAG
ATTGTTTGGGAGTTTGAGCAGCTGTATCACTCCTTAAAGGAGCATGAGTATCGCCTCCTGGCCCGCCTTGAGGAGCTAGACTTGGCCATC
TACAATAGCATCAATGGTGCCATCACCCAGTTCTCTTGCAACATCTCCCACCTCAGCAGCCTGATCGCTCAGCTAGAAGAGAAGCAGCAG
CAGCCCACCAGGGAGCTCCTGCAGGACATTGGGGACACATTGAGCAGGGCTGAAAGAATCAGGATTCCTGAACCTTGGATCACACCTCCA
GATTTGCAAGAGAAAATCCACATTTTTGCCCAAAAATGTCTATTCTTGACGGAGAGTCTAAAGCAGTTCACAGAAAAAATGCAGTCAGAT
ATGGAGAAAATCCAAGAATTAAGAGAGGCTCAGTTATACTCAGGGGGCAGCATTGTTGGGGGACACGAGCCTGGGGAGCCCCGGGGGATT
AAAGCTGGCTATGGCACCTGCAACTGCTTCCCTGAGGAGGAGAAGTGCTTCTGCGAGCCCGAAGACATCCAGGATCCACTGTGCGACGAG
CTGTGCCGCACGGTGATCGCAGCCGCTGTCCTCTTCTCCTTCATCGTCTCGGTGCTGCTGTCTGCCTTCTGCATCCACTGCTACCACAAG
TTTGCCCACAAGCCACCCATCTCCTCAGCTGAGATGACCTTCCGGAGGCCCGCCCAGGCCTTCCCGGTCAGCTACTCCTCTTCCGGTGCC
CGCCGGCCCTCGCTGGACTCCATGGAGAACCAGGTCTCCGTGGATGCCTTCAAGATCCTGGAGGATCCAAAGTGGGAATTCCCTCGGAAG
AACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTAC
ACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTC
AACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTG
CGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGAT
GAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCAT
CGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAG
GATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGT
GATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAAC
CTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCG
GACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACT
CCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTC
CCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGC
ACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTT
GATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGA
ACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGA
TAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCC
AGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATG
AAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAGTA
GGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCT
GGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAG
GAAGACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGTGG
TATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTG
ATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGC
CTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTG
AATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATT
ACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAA
TGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATG
CACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAA
AGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTATAT
AGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACA
CACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTCTT
TTACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCT
CAAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGA
CCCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTAT
TAGCTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTATTA
AAATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAATCAAGGTGACTAAGAAAATCAGTTGTGTAA

>In-frame_ENST00000377199_ENST00000355710_M16029_TRIM27_chr6_28875012_-_RET_chr10_43608999_length(amino acids)=891AA_start in transcript=213_stop in transcript=2888
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQ
LYSGGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAE
MTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------
>In-frame_ENST00000377199_ENST00000340058_M16029_TRIM27_chr6_28875012_-_RET_chr10_43608999_length(transcript)=3513nt_BP=1303nt
GTTTACGCTGCCGCCGGCATCCGCTCGGACGCGGCCACGTTGTCTTGCGCGCTTTGCCCGCCTGGCCCTGGGACTCTGACCCTCGGCTAC
CCTTTCCTGCCCCACTAGCGTGGCCGCGAGCCTCGGTGAGCCGGCCGTATTCCCGCTCTCGCTTAGGGGGCACAGGCGCAGGCATCGGCC
CGGCCACTCCAAGCCTTCGGTGCGCGGGCGCGTCTGGGATACGGGCCCGGGAGGCGCCGCCCTCCGTCCGCCCGGTGCCTCTCAGGAACA
GCGAACCGGAGAGAGCGCCGGAGAGTTGGGCTCAGTGCAGAGCTCGGCGCCGGGGCCCATGCCCGTGCGCCCCCGCAGGCCGGCGCCATG
GCCTCCGGGAGTGTGGCCGAGTGCCTGCAGCAGGAGACCACCTGCCCCGTGTGCCTGCAGTACTTCGCAGAGCCCATGATGCTCGACTGC
GGCCATAACATCTGTTGCGCGTGCCTCGCCCGCTGCTGGGGCACGGCAGAGACTAACGTGTCGTGCCCGCAGTGCCGGGAGACCTTCCCG
CAGAGGCACATGCGGCCCAACCGGCACCTGGCCAACGTGACCCAACTGGTAAAGCAGCTGCGCACCGAGCGGCCGTCGGGGCCCGGCGGC
GAGATGGGCGTGTGCGAGAAGCACCGCGAGCCCCTGAAGCTGTACTGCGAGGAGGACCAGATGCCCATCTGCGTGGTGTGCGACCGCTCC
CGCGAGCACCGCGGCCACAGCGTGCTGCCGCTCGAGGAGGCGGTGGAGGGCTTCAAGGAGCAAATCCAGAACCAGCTCGACCATTTAAAA
AGAGTGAAAGATTTAAAGAAGAGACGTCGGGCCCAGGGGGAACAGGCACGAGCTGAACTCTTGAGCCTAACCCAGATGGAGAGGGAGAAG
ATTGTTTGGGAGTTTGAGCAGCTGTATCACTCCTTAAAGGAGCATGAGTATCGCCTCCTGGCCCGCCTTGAGGAGCTAGACTTGGCCATC
TACAATAGCATCAATGGTGCCATCACCCAGTTCTCTTGCAACATCTCCCACCTCAGCAGCCTGATCGCTCAGCTAGAAGAGAAGCAGCAG
CAGCCCACCAGGGAGCTCCTGCAGGACATTGGGGACACATTGAGCAGGGCTGAAAGAATCAGGATTCCTGAACCTTGGATCACACCTCCA
GATTTGCAAGAGAAAATCCACATTTTTGCCCAAAAATGTCTATTCTTGACGGAGAGTCTAAAGCAGTTCACAGAAAAAATGCAGTCAGAT
ATGGAGAAAATCCAAGAATTAAGAGAGGCTCAGTTATACTCAGGGGGCAGCATTGTTGGGGGACACGAGCCTGGGGAGCCCCGGGGGATT
AAAGCTGGCTATGGCACCTGCAACTGCTTCCCTGAGGAGGAGAAGTGCTTCTGCGAGCCCGAAGACATCCAGGATCCACTGTGCGACGAG
CTGTGCCGCACGGTGATCGCAGCCGCTGTCCTCTTCTCCTTCATCGTCTCGGTGCTGCTGTCTGCCTTCTGCATCCACTGCTACCACAAG
TTTGCCCACAAGCCACCCATCTCCTCAGCTGAGATGACCTTCCGGAGGCCCGCCCAGGCCTTCCCGGTCAGCTACTCCTCTTCCGGTGCC
CGCCGGCCCTCGCTGGACTCCATGGAGAACCAGGTCTCCGTGGATGCCTTCAAGATCCTGGAGGATCCAAAGTGGGAATTCCCTCGGAAG
AACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTAC
ACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTC
AACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTG
CGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGAT
GAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCAT
CGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAG
GATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGT
GATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAAC
CTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCG
GACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACT
CCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTC
CCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTT
CCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTTGC
ATCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTAGG
ATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCA
TAGTACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCA
CTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGCCA
AGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTG
CTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGA
ACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAAACTCCTTCTTTTGTCTTTGATTAAATACTAGAAA

>In-frame_ENST00000377199_ENST00000340058_M16029_TRIM27_chr6_28875012_-_RET_chr10_43608999_length(amino acids)=849AA_start in transcript=213_stop in transcript=2762
MGYGPGRRRPPSARCLSGTANRRERRRVGLSAELGAGAHARAPPQAGAMASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLAR
CWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPL
EEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQF
SCNISHLSSLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQ
LYSGGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAE
MTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

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Top

Fusion Gene PPI Analysis for TRIM27-RET

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TRIM27-RET

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TRIM27-RET

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	TRIM27	C0238463	Papillary thyroid carcinoma	2	ORPHANET
Tgene	RET	C1833921	Familial medullary thyroid carcinoma	23	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	RET	C3888239	HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 1	16	GENOMICS_ENGLAND;UNIPROT
Tgene	RET	C0025268	Multiple Endocrine Neoplasia Type 2a	15	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	RET	C1708353	Hereditary Paraganglioma-Pheochromocytoma Syndrome	12	CLINGEN
Tgene	RET	C0025269	Multiple Endocrine Neoplasia Type 2b	10	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	RET	C0238463	Papillary thyroid carcinoma	3	CTD_human;ORPHANET
Tgene	RET	C1275808	Congenital central hypoventilation	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	RET	C1859049	CCHS WITH HIRSCHSPRUNG DISEASE	3	CTD_human;ORPHANET
Tgene	RET	C0009402	Colorectal Carcinoma	2	CTD_human;UNIPROT
Tgene	RET	C0009404	Colorectal Neoplasms	2	CTD_human
Tgene	RET	C0019569	Hirschsprung Disease	2	CTD_human
Tgene	RET	C0027662	Multiple Endocrine Neoplasia	2	CTD_human;GENOMICS_ENGLAND
Tgene	RET	C0085758	Aganglionosis, Colonic	2	CTD_human
Tgene	RET	C0266294	Unilateral agenesis of kidney	2	ORPHANET
Tgene	RET	C1257840	Aganglionosis, Rectosigmoid Colon	2	CTD_human
Tgene	RET	C3661523	Congenital Intestinal Aganglionosis	2	CTD_human
Tgene	RET	C0006413	Burkitt Lymphoma	1	CTD_human
Tgene	RET	C0031511	Pheochromocytoma	1	CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	RET	C0038220	Status Epilepticus	1	CTD_human
Tgene	RET	C0040136	Thyroid Neoplasm	1	CGI;CTD_human
Tgene	RET	C0151468	Thyroid Gland Follicular Adenoma	1	CTD_human
Tgene	RET	C0206693	Medullary carcinoma	1	CTD_human
Tgene	RET	C0238462	Medullary carcinoma of thyroid	1	CGI;CTD_human
Tgene	RET	C0270823	Petit mal status	1	CTD_human
Tgene	RET	C0311335	Grand Mal Status Epilepticus	1	CTD_human
Tgene	RET	C0343640	African Burkitt's lymphoma	1	CTD_human
Tgene	RET	C0393734	Complex Partial Status Epilepticus	1	CTD_human
Tgene	RET	C0549473	Thyroid carcinoma	1	CGI;CTD_human;UNIPROT
Tgene	RET	C0740340	Amyloidosis, Familial	1	CTD_human
Tgene	RET	C0751522	Status Epilepticus, Subclinical	1	CTD_human
Tgene	RET	C0751523	Non-Convulsive Status Epilepticus	1	CTD_human
Tgene	RET	C0751524	Simple Partial Status Epilepticus	1	CTD_human
Tgene	RET	C1257877	Pheochromocytoma, Extra-Adrenal	1	CTD_human
Tgene	RET	C1609433	Congenital absence of kidneys syndrome	1	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene	RET	C3501843	Nonmedullary Thyroid Carcinoma	1	CTD_human
Tgene	RET	C3501844	Familial Nonmedullary Thyroid Cancer	1	CTD_human
Tgene	RET	C4721444	Burkitt Leukemia	1	CTD_human