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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRIM29-TRIM29 (FusionGDB2 ID:93410)

Fusion Gene Summary for TRIM29-TRIM29

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM29-TRIM29
Fusion gene ID: 93410
HgeneTgene
Gene symbol

TRIM29

TRIM29

Gene ID

23650

23650

Gene nametripartite motif containing 29tripartite motif containing 29
SynonymsATDCATDC
Cytomap

11q23.3

11q23.3

Type of geneprotein-codingprotein-coding
Descriptiontripartite motif-containing protein 29ataxia-telangiectasia group D-associated proteintripartite motif protein TRIM29tripartite motif-containing protein 29ataxia-telangiectasia group D-associated proteintripartite motif protein TRIM29
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000341846, ENST00000524816, 
ENST00000541857, ENST00000525887, 
ENST00000528870, ENST00000529044, 
ENST00000341846, ENST00000524816, 
ENST00000541857, ENST00000525887, 
ENST00000528870, ENST00000529044, 
Fusion gene scores* DoF score9 X 10 X 7=6306 X 8 X 3=144
# samples 128
** MAII scorelog2(12/630*10)=-2.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIM29 [Title/Abstract] AND TRIM29 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRIM29(119988972)-TRIM29(119998126), # samples:1
TRIM29(119991311)-TRIM29(119996568), # samples:1
TRIM29(119982392)-TRIM29(120008415), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TRIM29 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TRIM29 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABG996534TRIM29chr11

119988972

-TRIM29chr11

119998126

-
ChiTaRS5.0N/ABF842536TRIM29chr11

119991311

-TRIM29chr11

119996568

+
ChiTaRS5.0N/ADB107228TRIM29chr11

119982392

-TRIM29chr11

120008415

-


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Fusion Gene ORF analysis for TRIM29-TRIM29

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000341846ENST00000341846TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000341846ENST00000524816TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000341846ENST00000541857TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000341846ENST00000525887TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000341846ENST00000528870TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000341846ENST00000529044TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-3CDSENST00000524816ENST00000341846TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000524816ENST00000524816TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000524816ENST00000541857TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000524816ENST00000525887TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000524816ENST00000528870TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000524816ENST00000529044TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-3CDSENST00000541857ENST00000341846TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000541857ENST00000524816TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000541857ENST00000541857TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000541857ENST00000525887TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000541857ENST00000528870TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000541857ENST00000529044TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-3CDSENST00000525887ENST00000341846TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000525887ENST00000524816TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000525887ENST00000541857TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000525887ENST00000525887TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000525887ENST00000528870TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000525887ENST00000529044TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-3CDSENST00000528870ENST00000341846TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000528870ENST00000524816TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000528870ENST00000541857TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000528870ENST00000525887TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000528870ENST00000528870TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000528870ENST00000529044TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-3CDSENST00000529044ENST00000341846TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000529044ENST00000524816TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000529044ENST00000541857TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000529044ENST00000525887TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000529044ENST00000528870TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-intronENST00000529044ENST00000529044TRIM29chr11

119988972

-TRIM29chr11

119998126

-
intron-3CDSENST00000341846ENST00000341846TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000341846ENST00000524816TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000341846ENST00000541857TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000341846ENST00000525887TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000341846ENST00000528870TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000341846ENST00000529044TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-3CDSENST00000524816ENST00000341846TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000524816ENST00000524816TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000524816ENST00000541857TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000524816ENST00000525887TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000524816ENST00000528870TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000524816ENST00000529044TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-3CDSENST00000541857ENST00000341846TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000541857ENST00000524816TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000541857ENST00000541857TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000541857ENST00000525887TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000541857ENST00000528870TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000541857ENST00000529044TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-3CDSENST00000525887ENST00000341846TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000525887ENST00000524816TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000525887ENST00000541857TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000525887ENST00000525887TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000525887ENST00000528870TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000525887ENST00000529044TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-3CDSENST00000528870ENST00000341846TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000528870ENST00000524816TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000528870ENST00000541857TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000528870ENST00000525887TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000528870ENST00000528870TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000528870ENST00000529044TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-3CDSENST00000529044ENST00000341846TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000529044ENST00000524816TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000529044ENST00000541857TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000529044ENST00000525887TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000529044ENST00000528870TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-intronENST00000529044ENST00000529044TRIM29chr11

119991311

-TRIM29chr11

119996568

+
intron-3CDSENST00000341846ENST00000341846TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000341846ENST00000524816TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000341846ENST00000541857TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000341846ENST00000525887TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000341846ENST00000528870TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000341846ENST00000529044TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-3CDSENST00000524816ENST00000341846TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000524816ENST00000524816TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000524816ENST00000541857TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000524816ENST00000525887TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000524816ENST00000528870TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000524816ENST00000529044TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-3CDSENST00000541857ENST00000341846TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000541857ENST00000524816TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000541857ENST00000541857TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000541857ENST00000525887TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000541857ENST00000528870TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000541857ENST00000529044TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-3CDSENST00000525887ENST00000341846TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000525887ENST00000524816TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000525887ENST00000541857TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000525887ENST00000525887TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000525887ENST00000528870TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000525887ENST00000529044TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-3CDSENST00000528870ENST00000341846TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000528870ENST00000524816TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000528870ENST00000541857TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000528870ENST00000525887TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000528870ENST00000528870TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000528870ENST00000529044TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-3CDSENST00000529044ENST00000341846TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000529044ENST00000524816TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000529044ENST00000541857TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000529044ENST00000525887TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000529044ENST00000528870TRIM29chr11

119982392

-TRIM29chr11

120008415

-
intron-intronENST00000529044ENST00000529044TRIM29chr11

119982392

-TRIM29chr11

120008415

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TRIM29-TRIM29


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRIM29-TRIM29


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TRIM29-TRIM29


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TRIM29-TRIM29


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRIM29-TRIM29


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRIM29-TRIM29


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIM29C0017638Glioma1CTD_human
HgeneTRIM29C0259783mixed gliomas1CTD_human
HgeneTRIM29C0555198Malignant Glioma1CTD_human
TgeneTRIM29C0017638Glioma1CTD_human
TgeneTRIM29C0259783mixed gliomas1CTD_human
TgeneTRIM29C0555198Malignant Glioma1CTD_human