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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRIM33-RET (FusionGDB2 ID:93427)

Fusion Gene Summary for TRIM33-RET

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIM33-RET
Fusion gene ID: 93427
HgeneTgene
Gene symbol

TRIM33

RET

Gene ID

51592

5979

Gene nametripartite motif containing 33ret proto-oncogene
SynonymsECTO|PTC7|RFG7|TF1G|TIF1G|TIF1GAMMA|TIFGAMMACDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1
Cytomap

1p13.2

10q11.21

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase TRIM33RET-fused gene 7 proteinRING-type E3 ubiquitin transferase TRIM33TIF1-gammaectodermin homologprotein Rfg7transcriptional intermediary factor 1 gammaproto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary
Modification date2020031320200322
UniProtAcc.

RTL1

Ensembl transtripts involved in fusion geneENST00000358465, ENST00000369543, 
ENST00000450349, ENST00000476908, 
ENST00000355710, ENST00000340058, 
Fusion gene scores* DoF score17 X 18 X 10=306032 X 31 X 11=10912
# samples 2148
** MAII scorelog2(21/3060*10)=-3.86507041991389
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(48/10912*10)=-4.50673733341565
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIM33 [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRIM33(114964058)-RET(43612032), # samples:3
Anticipated loss of major functional domain due to fusion event.TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM33

GO:0016567

protein ubiquitination

19135894

HgeneTRIM33

GO:0017015

regulation of transforming growth factor beta receptor signaling pathway

19135894

HgeneTRIM33

GO:0030514

negative regulation of BMP signaling pathway

19135894

TgeneRET

GO:0030155

regulation of cell adhesion

21357690

TgeneRET

GO:0030335

positive regulation of cell migration

20702524

TgeneRET

GO:0033619

membrane protein proteolysis

21357690

TgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

TgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

TgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099


check buttonFusion gene breakpoints across TRIM33 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-6543-01ATRIM33chr1

114964058

-RETchr10

43612032

+
ChimerDB4LUADTCGA-55-6543TRIM33chr1

114964057

-RETchr10

43612031

+
ChimerDB4LUADTCGA-55-6543-01ATRIM33chr1

114964058

-RETchr10

43612032

+
ChimerDB4LUADTCGA-55-6543-01ATRIM33chr1

114964058

-RETchr10

43612032

+


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Fusion Gene ORF analysis for TRIM33-RET

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000358465ENST00000355710TRIM33chr1

114964058

-RETchr10

43612032

+
In-frameENST00000358465ENST00000340058TRIM33chr1

114964058

-RETchr10

43612032

+
In-frameENST00000369543ENST00000355710TRIM33chr1

114964058

-RETchr10

43612032

+
In-frameENST00000369543ENST00000340058TRIM33chr1

114964058

-RETchr10

43612032

+
Frame-shiftENST00000450349ENST00000355710TRIM33chr1

114964058

-RETchr10

43612032

+
Frame-shiftENST00000450349ENST00000340058TRIM33chr1

114964058

-RETchr10

43612032

+
intron-3CDSENST00000476908ENST00000355710TRIM33chr1

114964058

-RETchr10

43612032

+
intron-3CDSENST00000476908ENST00000340058TRIM33chr1

114964058

-RETchr10

43612032

+
In-frameENST00000358465ENST00000355710TRIM33chr1

114964057

-RETchr10

43612031

+
In-frameENST00000358465ENST00000340058TRIM33chr1

114964057

-RETchr10

43612031

+
In-frameENST00000369543ENST00000355710TRIM33chr1

114964057

-RETchr10

43612031

+
In-frameENST00000369543ENST00000340058TRIM33chr1

114964057

-RETchr10

43612031

+
Frame-shiftENST00000450349ENST00000355710TRIM33chr1

114964057

-RETchr10

43612031

+
Frame-shiftENST00000450349ENST00000340058TRIM33chr1

114964057

-RETchr10

43612031

+
intron-3CDSENST00000476908ENST00000355710TRIM33chr1

114964057

-RETchr10

43612031

+
intron-3CDSENST00000476908ENST00000340058TRIM33chr1

114964057

-RETchr10

43612031

+
Frame-shiftENST00000358465ENST00000340058TRIM33chr1

114944010

-RETchr10

43609927

+
Frame-shiftENST00000358465ENST00000355710TRIM33chr1

114944010

-RETchr10

43609927

+
Frame-shiftENST00000369543ENST00000340058TRIM33chr1

114944010

-RETchr10

43609927

+
Frame-shiftENST00000369543ENST00000355710TRIM33chr1

114944010

-RETchr10

43609927

+
Frame-shiftENST00000450349ENST00000340058TRIM33chr1

114944010

-RETchr10

43609927

+
Frame-shiftENST00000450349ENST00000340058TRIM33chr1

114945381

-RETchr10

43612031

+
Frame-shiftENST00000450349ENST00000355710TRIM33chr1

114944010

-RETchr10

43609927

+
Frame-shiftENST00000450349ENST00000355710TRIM33chr1

114945381

-RETchr10

43612031

+
In-frameENST00000358465ENST00000340058TRIM33chr1

114945381

-RETchr10

43612031

+
In-frameENST00000358465ENST00000355710TRIM33chr1

114945381

-RETchr10

43612031

+
In-frameENST00000369543ENST00000340058TRIM33chr1

114945381

-RETchr10

43612031

+
In-frameENST00000369543ENST00000355710TRIM33chr1

114945381

-RETchr10

43612031

+
intron-3CDSENST00000476908ENST00000340058TRIM33chr1

114944010

-RETchr10

43609927

+
intron-3CDSENST00000476908ENST00000340058TRIM33chr1

114945381

-RETchr10

43612031

+
intron-3CDSENST00000476908ENST00000355710TRIM33chr1

114944010

-RETchr10

43609927

+
intron-3CDSENST00000476908ENST00000355710TRIM33chr1

114945381

-RETchr10

43612031

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358465TRIM33chr1114964058-ENST00000355710RETchr1043612032+54362145033531117
ENST00000358465TRIM33chr1114964058-ENST00000340058RETchr1043612032+39782145032271075
ENST00000369543TRIM33chr1114964058-ENST00000355710RETchr1043612032+54362145033531117
ENST00000369543TRIM33chr1114964058-ENST00000340058RETchr1043612032+39782145032271075
ENST00000358465TRIM33chr1114964057-ENST00000355710RETchr1043612031+54362145033531117
ENST00000358465TRIM33chr1114964057-ENST00000340058RETchr1043612031+39782145032271075
ENST00000369543TRIM33chr1114964057-ENST00000355710RETchr1043612031+54362145033531117
ENST00000369543TRIM33chr1114964057-ENST00000340058RETchr1043612031+39782145032271075

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358465ENST00000355710TRIM33chr1114964058-RETchr1043612032+0.0007377930.99926215
ENST00000358465ENST00000340058TRIM33chr1114964058-RETchr1043612032+0.0033106510.9966893
ENST00000369543ENST00000355710TRIM33chr1114964058-RETchr1043612032+0.0007377930.99926215
ENST00000369543ENST00000340058TRIM33chr1114964058-RETchr1043612032+0.0033106510.9966893
ENST00000358465ENST00000355710TRIM33chr1114964057-RETchr1043612031+0.0007377930.99926215
ENST00000358465ENST00000340058TRIM33chr1114964057-RETchr1043612031+0.0033106510.9966893
ENST00000369543ENST00000355710TRIM33chr1114964057-RETchr1043612031+0.0007377930.99926215
ENST00000369543ENST00000340058TRIM33chr1114964057-RETchr1043612031+0.0033106510.9966893

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Fusion Genomic Features for TRIM33-RET


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TRIM33chr1114964057-RETchr1043612031+3.23E-050.9999677
TRIM33chr1114964057-RETchr1043612031+3.23E-050.9999677
TRIM33chr1114964057-RETchr1043612031+3.23E-050.9999677
TRIM33chr1114964057-RETchr1043612031+3.23E-050.9999677

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRIM33-RET


check button Go to

FGviewer for the breakpoints of chr1:114964058-chr10:43612032

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RET

RTL1

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.1358

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM33chr1:114964057chr10:43612031ENST00000358465-1120299_401687.01128.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM33chr1:114964057chr10:43612031ENST00000369543-1119299_401687.01111.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120299_401687.01128.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119299_401687.01111.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM33chr1:114964057chr10:43612031ENST00000358465-112013_18687.01128.0Compositional biasNote=Poly-Gly
HgeneTRIM33chr1:114964057chr10:43612031ENST00000358465-112044_49687.01128.0Compositional biasNote=Poly-Glu
HgeneTRIM33chr1:114964057chr10:43612031ENST00000358465-1120545_550687.01128.0Compositional biasNote=Poly-Thr
HgeneTRIM33chr1:114964057chr10:43612031ENST00000369543-111913_18687.01111.0Compositional biasNote=Poly-Gly
HgeneTRIM33chr1:114964057chr10:43612031ENST00000369543-111944_49687.01111.0Compositional biasNote=Poly-Glu
HgeneTRIM33chr1:114964057chr10:43612031ENST00000369543-1119545_550687.01111.0Compositional biasNote=Poly-Thr
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-112013_18687.01128.0Compositional biasNote=Poly-Gly
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-112044_49687.01128.0Compositional biasNote=Poly-Glu
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120545_550687.01128.0Compositional biasNote=Poly-Thr
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-111913_18687.01111.0Compositional biasNote=Poly-Gly
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-111944_49687.01111.0Compositional biasNote=Poly-Glu
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119545_550687.01111.0Compositional biasNote=Poly-Thr
HgeneTRIM33chr1:114964057chr10:43612031ENST00000358465-11201_147687.01128.0RegionNote=Necessary for E3 ubiquitin-protein ligase activity and repression of SMAD4 signaling and transcriptional repression
HgeneTRIM33chr1:114964057chr10:43612031ENST00000369543-11191_147687.01111.0RegionNote=Necessary for E3 ubiquitin-protein ligase activity and repression of SMAD4 signaling and transcriptional repression
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-11201_147687.01128.0RegionNote=Necessary for E3 ubiquitin-protein ligase activity and repression of SMAD4 signaling and transcriptional repression
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-11191_147687.01111.0RegionNote=Necessary for E3 ubiquitin-protein ligase activity and repression of SMAD4 signaling and transcriptional repression
HgeneTRIM33chr1:114964057chr10:43612031ENST00000358465-1120125_154687.01128.0Zinc fingerRING-type
HgeneTRIM33chr1:114964057chr10:43612031ENST00000358465-1120212_259687.01128.0Zinc fingerB box-type 1
HgeneTRIM33chr1:114964057chr10:43612031ENST00000358465-1120271_312687.01128.0Zinc fingerB box-type 2
HgeneTRIM33chr1:114964057chr10:43612031ENST00000369543-1119125_154687.01111.0Zinc fingerRING-type
HgeneTRIM33chr1:114964057chr10:43612031ENST00000369543-1119212_259687.01111.0Zinc fingerB box-type 1
HgeneTRIM33chr1:114964057chr10:43612031ENST00000369543-1119271_312687.01111.0Zinc fingerB box-type 2
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120125_154687.01128.0Zinc fingerRING-type
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120212_259687.01128.0Zinc fingerB box-type 1
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120271_312687.01128.0Zinc fingerB box-type 2
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119125_154687.01111.0Zinc fingerRING-type
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119212_259687.01111.0Zinc fingerB box-type 1
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119271_312687.01111.0Zinc fingerB box-type 2
TgeneRETchr1:114964057chr10:43612031ENST000003400581019724_1016712.01073.0DomainProtein kinase
TgeneRETchr1:114964057chr10:43612031ENST000003557101020724_1016712.01115.0DomainProtein kinase
TgeneRETchr1:114964058chr10:43612032ENST000003400581019724_1016712.01073.0DomainProtein kinase
TgeneRETchr1:114964058chr10:43612032ENST000003557101020724_1016712.01115.0DomainProtein kinase
TgeneRETchr1:114964057chr10:43612031ENST000003400581019730_738712.01073.0Nucleotide bindingATP
TgeneRETchr1:114964057chr10:43612031ENST000003557101020730_738712.01115.0Nucleotide bindingATP
TgeneRETchr1:114964058chr10:43612032ENST000003400581019730_738712.01073.0Nucleotide bindingATP
TgeneRETchr1:114964058chr10:43612032ENST000003557101020730_738712.01115.0Nucleotide bindingATP
TgeneRETchr1:114964057chr10:43612031ENST000003400581019805_807712.01073.0RegionNote=Inhibitors binding
TgeneRETchr1:114964057chr10:43612031ENST000003557101020805_807712.01115.0RegionNote=Inhibitors binding
TgeneRETchr1:114964058chr10:43612032ENST000003400581019805_807712.01073.0RegionNote=Inhibitors binding
TgeneRETchr1:114964058chr10:43612032ENST000003557101020805_807712.01115.0RegionNote=Inhibitors binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM33chr1:114964057chr10:43612031ENST00000358465-1120974_1046687.01128.0DomainBromo
HgeneTRIM33chr1:114964057chr10:43612031ENST00000369543-1119974_1046687.01111.0DomainBromo
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120974_1046687.01128.0DomainBromo
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119974_1046687.01111.0DomainBromo
HgeneTRIM33chr1:114964057chr10:43612031ENST00000358465-1120887_934687.01128.0Zinc fingerPHD-type
HgeneTRIM33chr1:114964057chr10:43612031ENST00000369543-1119887_934687.01111.0Zinc fingerPHD-type
HgeneTRIM33chr1:114964058chr10:43612032ENST00000358465-1120887_934687.01128.0Zinc fingerPHD-type
HgeneTRIM33chr1:114964058chr10:43612032ENST00000369543-1119887_934687.01111.0Zinc fingerPHD-type
TgeneRETchr1:114964057chr10:43612031ENST000003400581019168_272712.01073.0DomainCadherin
TgeneRETchr1:114964057chr10:43612031ENST000003557101020168_272712.01115.0DomainCadherin
TgeneRETchr1:114964058chr10:43612032ENST000003400581019168_272712.01073.0DomainCadherin
TgeneRETchr1:114964058chr10:43612032ENST000003557101020168_272712.01115.0DomainCadherin
TgeneRETchr1:114964057chr10:43612031ENST00000340058101929_635712.01073.0Topological domainExtracellular
TgeneRETchr1:114964057chr10:43612031ENST000003400581019658_1114712.01073.0Topological domainCytoplasmic
TgeneRETchr1:114964057chr10:43612031ENST00000355710102029_635712.01115.0Topological domainExtracellular
TgeneRETchr1:114964057chr10:43612031ENST000003557101020658_1114712.01115.0Topological domainCytoplasmic
TgeneRETchr1:114964058chr10:43612032ENST00000340058101929_635712.01073.0Topological domainExtracellular
TgeneRETchr1:114964058chr10:43612032ENST000003400581019658_1114712.01073.0Topological domainCytoplasmic
TgeneRETchr1:114964058chr10:43612032ENST00000355710102029_635712.01115.0Topological domainExtracellular
TgeneRETchr1:114964058chr10:43612032ENST000003557101020658_1114712.01115.0Topological domainCytoplasmic
TgeneRETchr1:114964057chr10:43612031ENST000003400581019636_657712.01073.0TransmembraneHelical
TgeneRETchr1:114964057chr10:43612031ENST000003557101020636_657712.01115.0TransmembraneHelical
TgeneRETchr1:114964058chr10:43612032ENST000003400581019636_657712.01073.0TransmembraneHelical
TgeneRETchr1:114964058chr10:43612032ENST000003557101020636_657712.01115.0TransmembraneHelical


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Fusion Gene Sequence for TRIM33-RET


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000358465_ENST00000355710_TCGA-55-6543-01A_TRIM33_chr1_114964058_-_RET_chr10_43612032_length(transcript)=5436nt_BP=2145nt
CTGCGGCTGGGGCTGGGGGCGGCGGCGGCGGCGACGCGGGCGGCGGGCGGCGCGGGGCGGTCCGGCGGGTTCAAAGAGGAAAACATGGCG
GAAAACAAAGGCGGCGGCGAGGCTGAGAGCGGCGGCGGGGGCAGCGGCAGCGCGCCGGTAACTGCCGGGGCCGCCGGGCCCGCCGCGCAG
GAGGCGGAGCCGCCTCTCACCGCGGTGCTGGTGGAGGAGGAGGAGGAGGAAGGCGGCAGGGCCGGCGCTGAGGGCGGCGCGGCCGGGCCC
GACGACGGGGGGGTGGCCGCGGCCTCCTCGGGCTCGGCCCAGGCTGCTTCATCTCCTGCGGCCTCAGTGGGCACTGGAGTTGCCGGGGGC
GCAGTATCGACGCCGGCTCCAGCTCCAGCCTCGGCTCCCGCTCCGGGTCCCTCGGCAGGGCCGCCTCCTGGACCGCCAGCCTCGCTCCTG
GACACCTGCGCCGTGTGTCAGCAGAGCTTGCAGAGCCGGCGTGAGGCGGAGCCCAAGCTGCTGCCCTGTCTTCACTCCTTCTGCCTGCGC
TGCCTGCCCGAGCCGGAGCGCCAGCTCAGCGTGCCCATCCCGGGGGGCAGCAACGGCGACATCCAGCAAGTTGGTGTAATACGGTGCCCA
GTATGCCGCCAAGAATGCAGACAGATAGACCTTGTGGATAATTATTTTGTGAAAGACACATCTGAAGCTCCTAGCAGTTCTGATGAAAAA
TCAGAACAGGTATGTACTAGTTGTGAAGACAATGCAAGTGCAGTTGGCTTTTGTGTAGAATGTGGAGAGTGGCTATGTAAGACATGTATC
GAAGCACATCAAAGAGTAAAATTTACTAAAGATCACTTGATCAGGAAGAAAGAAGATGTCTCAGAGTCTGTTGGAGCATCTGGTCAACGC
CCTGTTTTCTGCCCTGTACACAAACAAGAACAGTTGAAACTTTTCTGTGAAACATGTGATAGATTGACATGTAGAGACTGTCAGCTATTG
GAACACAAAGAACATAGGTATCAGTTTTTGGAAGAAGCTTTTCAAAATCAGAAGGGTGCAATTGAGAATCTACTGGCGAAACTTCTTGAG
AAGAAGAATTATGTTCATTTTGCAGCTACTCAGGTGCAGAATAGGATAAAAGAAGTAAATGAGACTAACAAACGAGTAGAACAGGAAATT
AAAGTGGCCATTTTCACCCTTATCAATGAAATTAATAAGAAAGGAAAATCTCTCTTACAACAGCTAGAGAATGTTACAAAGGAAAGACAG
ATGAAGTTACTACAGCAGCAGAATGACATCACAGGCCTTTCCCGGCAGGTGAAGCATGTTATGAACTTCACAAATTGGGCAATTGCAAGT
GGCAGCAGCACAGCACTACTATACAGCAAGCGACTGATTACTTTCCAGTTGCGTCATATTTTGAAAGCACGGTGTGATCCTGTCCCTGCT
GCTAATGGAGCAATACGTTTCCATTGTGATCCCACCTTCTGGGCAAAGAATGTAGTCAATTTAGGTAATCTAGTAATAGAGAGTAAACCA
GCTCCTGGTTATACTCCTAATGTTGTAGTTGGGCAAGTTCCTCCAGGGACAAACCACATTAGTAAAACCCCTGGACAGATTAACTTAGCA
CAGCTTCGACTCCAGCACATGCAACAACAAGTATATGCACAGAAACATCAGCAGTTGCAACAGATGAGGATGCAGCAACCACCAGCACCT
GTACCAACTACAACAACAACAACACAACAGCATCCTAGACAAGCAGCCCCTCAGATGTTACAACAACAGCCTCCTCGATTGATCAGTGTG
CAAACAATGCAAAGAGGCAACATGAACTGTGGAGCTTTTCAAGCCCATCAGATGAGACTGGCTCAGAATGCTGCCAGAATACCAGGGATA
CCCAGGCACAGCGGCCCTCAATATTCCATGATGCAGCCACACCTCCAAAGACAACACTCAAACCCAGGGCATGCTGGACCCTTTCCCGTA
GTATCGGTACACAACACCACAATCAACCCAACGAGCCCTACTACAGCAACTATGGCAAATGCAAACCGAGGTCCCACCAGCCCATCTGTT
ACAGCAATAGAGCTAATCCCCTCAGTTACCAATCCAGAAAACCTTCCATCGCTGCCAGATATTCCACCCATACAGGAGGATCCAAAGTGG
GAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAA
GGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAAC
GTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCC
AAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCC
CTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAG
ATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGA
GATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATC
TACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCT
GAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGC
TGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGAC
CTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCC
CTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTC
ACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAA
TTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCG
GCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGG
TGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCT
TTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTT
ACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACAC
ACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAA
TGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCAT
GCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTA
CTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAG
CAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATC
CCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGT
ACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACT
GCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCT
GTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGT
TTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACT
GTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAA
TACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTG
TGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACA
CTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAAT
AAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCA
GGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAA
AGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTA
ATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAATCAAGGTGACTAAGA

>In-frame_ENST00000358465_ENST00000355710_TCGA-55-6543-01A_TRIM33_chr1_114964058_-_RET_chr10_43612032_length(amino acids)=1117AA_start in transcript=0_stop in transcript=3353
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA
KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQC
WKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPL

--------------------------------------------------------------
>In-frame_ENST00000358465_ENST00000340058_TCGA-55-6543-01A_TRIM33_chr1_114964058_-_RET_chr10_43612032_length(transcript)=3978nt_BP=2145nt
CTGCGGCTGGGGCTGGGGGCGGCGGCGGCGGCGACGCGGGCGGCGGGCGGCGCGGGGCGGTCCGGCGGGTTCAAAGAGGAAAACATGGCG
GAAAACAAAGGCGGCGGCGAGGCTGAGAGCGGCGGCGGGGGCAGCGGCAGCGCGCCGGTAACTGCCGGGGCCGCCGGGCCCGCCGCGCAG
GAGGCGGAGCCGCCTCTCACCGCGGTGCTGGTGGAGGAGGAGGAGGAGGAAGGCGGCAGGGCCGGCGCTGAGGGCGGCGCGGCCGGGCCC
GACGACGGGGGGGTGGCCGCGGCCTCCTCGGGCTCGGCCCAGGCTGCTTCATCTCCTGCGGCCTCAGTGGGCACTGGAGTTGCCGGGGGC
GCAGTATCGACGCCGGCTCCAGCTCCAGCCTCGGCTCCCGCTCCGGGTCCCTCGGCAGGGCCGCCTCCTGGACCGCCAGCCTCGCTCCTG
GACACCTGCGCCGTGTGTCAGCAGAGCTTGCAGAGCCGGCGTGAGGCGGAGCCCAAGCTGCTGCCCTGTCTTCACTCCTTCTGCCTGCGC
TGCCTGCCCGAGCCGGAGCGCCAGCTCAGCGTGCCCATCCCGGGGGGCAGCAACGGCGACATCCAGCAAGTTGGTGTAATACGGTGCCCA
GTATGCCGCCAAGAATGCAGACAGATAGACCTTGTGGATAATTATTTTGTGAAAGACACATCTGAAGCTCCTAGCAGTTCTGATGAAAAA
TCAGAACAGGTATGTACTAGTTGTGAAGACAATGCAAGTGCAGTTGGCTTTTGTGTAGAATGTGGAGAGTGGCTATGTAAGACATGTATC
GAAGCACATCAAAGAGTAAAATTTACTAAAGATCACTTGATCAGGAAGAAAGAAGATGTCTCAGAGTCTGTTGGAGCATCTGGTCAACGC
CCTGTTTTCTGCCCTGTACACAAACAAGAACAGTTGAAACTTTTCTGTGAAACATGTGATAGATTGACATGTAGAGACTGTCAGCTATTG
GAACACAAAGAACATAGGTATCAGTTTTTGGAAGAAGCTTTTCAAAATCAGAAGGGTGCAATTGAGAATCTACTGGCGAAACTTCTTGAG
AAGAAGAATTATGTTCATTTTGCAGCTACTCAGGTGCAGAATAGGATAAAAGAAGTAAATGAGACTAACAAACGAGTAGAACAGGAAATT
AAAGTGGCCATTTTCACCCTTATCAATGAAATTAATAAGAAAGGAAAATCTCTCTTACAACAGCTAGAGAATGTTACAAAGGAAAGACAG
ATGAAGTTACTACAGCAGCAGAATGACATCACAGGCCTTTCCCGGCAGGTGAAGCATGTTATGAACTTCACAAATTGGGCAATTGCAAGT
GGCAGCAGCACAGCACTACTATACAGCAAGCGACTGATTACTTTCCAGTTGCGTCATATTTTGAAAGCACGGTGTGATCCTGTCCCTGCT
GCTAATGGAGCAATACGTTTCCATTGTGATCCCACCTTCTGGGCAAAGAATGTAGTCAATTTAGGTAATCTAGTAATAGAGAGTAAACCA
GCTCCTGGTTATACTCCTAATGTTGTAGTTGGGCAAGTTCCTCCAGGGACAAACCACATTAGTAAAACCCCTGGACAGATTAACTTAGCA
CAGCTTCGACTCCAGCACATGCAACAACAAGTATATGCACAGAAACATCAGCAGTTGCAACAGATGAGGATGCAGCAACCACCAGCACCT
GTACCAACTACAACAACAACAACACAACAGCATCCTAGACAAGCAGCCCCTCAGATGTTACAACAACAGCCTCCTCGATTGATCAGTGTG
CAAACAATGCAAAGAGGCAACATGAACTGTGGAGCTTTTCAAGCCCATCAGATGAGACTGGCTCAGAATGCTGCCAGAATACCAGGGATA
CCCAGGCACAGCGGCCCTCAATATTCCATGATGCAGCCACACCTCCAAAGACAACACTCAAACCCAGGGCATGCTGGACCCTTTCCCGTA
GTATCGGTACACAACACCACAATCAACCCAACGAGCCCTACTACAGCAACTATGGCAAATGCAAACCGAGGTCCCACCAGCCCATCTGTT
ACAGCAATAGAGCTAATCCCCTCAGTTACCAATCCAGAAAACCTTCCATCGCTGCCAGATATTCCACCCATACAGGAGGATCCAAAGTGG
GAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAA
GGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAAC
GTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCC
AAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCC
CTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAG
ATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGA
GATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATC
TACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCT
GAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGC
TGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGAC
CTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCC
CTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCC
CTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTA
AATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATT
GCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGG
GTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGC
ACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCG
AGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAG
GACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAG
TTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAAACTCCTTCTTTTGTCTTTG

>In-frame_ENST00000358465_ENST00000340058_TCGA-55-6543-01A_TRIM33_chr1_114964058_-_RET_chr10_43612032_length(amino acids)=1075AA_start in transcript=0_stop in transcript=3227
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA
KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQC

--------------------------------------------------------------
>In-frame_ENST00000369543_ENST00000355710_TCGA-55-6543-01A_TRIM33_chr1_114964058_-_RET_chr10_43612032_length(transcript)=5436nt_BP=2145nt
CTGCGGCTGGGGCTGGGGGCGGCGGCGGCGGCGACGCGGGCGGCGGGCGGCGCGGGGCGGTCCGGCGGGTTCAAAGAGGAAAACATGGCG
GAAAACAAAGGCGGCGGCGAGGCTGAGAGCGGCGGCGGGGGCAGCGGCAGCGCGCCGGTAACTGCCGGGGCCGCCGGGCCCGCCGCGCAG
GAGGCGGAGCCGCCTCTCACCGCGGTGCTGGTGGAGGAGGAGGAGGAGGAAGGCGGCAGGGCCGGCGCTGAGGGCGGCGCGGCCGGGCCC
GACGACGGGGGGGTGGCCGCGGCCTCCTCGGGCTCGGCCCAGGCTGCTTCATCTCCTGCGGCCTCAGTGGGCACTGGAGTTGCCGGGGGC
GCAGTATCGACGCCGGCTCCAGCTCCAGCCTCGGCTCCCGCTCCGGGTCCCTCGGCAGGGCCGCCTCCTGGACCGCCAGCCTCGCTCCTG
GACACCTGCGCCGTGTGTCAGCAGAGCTTGCAGAGCCGGCGTGAGGCGGAGCCCAAGCTGCTGCCCTGTCTTCACTCCTTCTGCCTGCGC
TGCCTGCCCGAGCCGGAGCGCCAGCTCAGCGTGCCCATCCCGGGGGGCAGCAACGGCGACATCCAGCAAGTTGGTGTAATACGGTGCCCA
GTATGCCGCCAAGAATGCAGACAGATAGACCTTGTGGATAATTATTTTGTGAAAGACACATCTGAAGCTCCTAGCAGTTCTGATGAAAAA
TCAGAACAGGTATGTACTAGTTGTGAAGACAATGCAAGTGCAGTTGGCTTTTGTGTAGAATGTGGAGAGTGGCTATGTAAGACATGTATC
GAAGCACATCAAAGAGTAAAATTTACTAAAGATCACTTGATCAGGAAGAAAGAAGATGTCTCAGAGTCTGTTGGAGCATCTGGTCAACGC
CCTGTTTTCTGCCCTGTACACAAACAAGAACAGTTGAAACTTTTCTGTGAAACATGTGATAGATTGACATGTAGAGACTGTCAGCTATTG
GAACACAAAGAACATAGGTATCAGTTTTTGGAAGAAGCTTTTCAAAATCAGAAGGGTGCAATTGAGAATCTACTGGCGAAACTTCTTGAG
AAGAAGAATTATGTTCATTTTGCAGCTACTCAGGTGCAGAATAGGATAAAAGAAGTAAATGAGACTAACAAACGAGTAGAACAGGAAATT
AAAGTGGCCATTTTCACCCTTATCAATGAAATTAATAAGAAAGGAAAATCTCTCTTACAACAGCTAGAGAATGTTACAAAGGAAAGACAG
ATGAAGTTACTACAGCAGCAGAATGACATCACAGGCCTTTCCCGGCAGGTGAAGCATGTTATGAACTTCACAAATTGGGCAATTGCAAGT
GGCAGCAGCACAGCACTACTATACAGCAAGCGACTGATTACTTTCCAGTTGCGTCATATTTTGAAAGCACGGTGTGATCCTGTCCCTGCT
GCTAATGGAGCAATACGTTTCCATTGTGATCCCACCTTCTGGGCAAAGAATGTAGTCAATTTAGGTAATCTAGTAATAGAGAGTAAACCA
GCTCCTGGTTATACTCCTAATGTTGTAGTTGGGCAAGTTCCTCCAGGGACAAACCACATTAGTAAAACCCCTGGACAGATTAACTTAGCA
CAGCTTCGACTCCAGCACATGCAACAACAAGTATATGCACAGAAACATCAGCAGTTGCAACAGATGAGGATGCAGCAACCACCAGCACCT
GTACCAACTACAACAACAACAACACAACAGCATCCTAGACAAGCAGCCCCTCAGATGTTACAACAACAGCCTCCTCGATTGATCAGTGTG
CAAACAATGCAAAGAGGCAACATGAACTGTGGAGCTTTTCAAGCCCATCAGATGAGACTGGCTCAGAATGCTGCCAGAATACCAGGGATA
CCCAGGCACAGCGGCCCTCAATATTCCATGATGCAGCCACACCTCCAAAGACAACACTCAAACCCAGGGCATGCTGGACCCTTTCCCGTA
GTATCGGTACACAACACCACAATCAACCCAACGAGCCCTACTACAGCAACTATGGCAAATGCAAACCGAGGTCCCACCAGCCCATCTGTT
ACAGCAATAGAGCTAATCCCCTCAGTTACCAATCCAGAAAACCTTCCATCGCTGCCAGATATTCCACCCATACAGGAGGATCCAAAGTGG
GAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAA
GGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAAC
GTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCC
AAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCC
CTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAG
ATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGA
GATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATC
TACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCT
GAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGC
TGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGAC
CTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCC
CTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTC
ACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAA
TTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCG
GCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGG
TGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCT
TTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTT
ACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACAC
ACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAA
TGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCAT
GCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTA
CTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAG
CAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATC
CCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGT
ACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACT
GCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCT
GTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGT
TTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACT
GTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAA
TACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTG
TGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACA
CTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAAT
AAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCA
GGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAA
AGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTA
ATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAATCAAGGTGACTAAGA

>In-frame_ENST00000369543_ENST00000355710_TCGA-55-6543-01A_TRIM33_chr1_114964058_-_RET_chr10_43612032_length(amino acids)=1117AA_start in transcript=0_stop in transcript=3353
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA
KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQC
WKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPL

--------------------------------------------------------------
>In-frame_ENST00000369543_ENST00000340058_TCGA-55-6543-01A_TRIM33_chr1_114964058_-_RET_chr10_43612032_length(transcript)=3978nt_BP=2145nt
CTGCGGCTGGGGCTGGGGGCGGCGGCGGCGGCGACGCGGGCGGCGGGCGGCGCGGGGCGGTCCGGCGGGTTCAAAGAGGAAAACATGGCG
GAAAACAAAGGCGGCGGCGAGGCTGAGAGCGGCGGCGGGGGCAGCGGCAGCGCGCCGGTAACTGCCGGGGCCGCCGGGCCCGCCGCGCAG
GAGGCGGAGCCGCCTCTCACCGCGGTGCTGGTGGAGGAGGAGGAGGAGGAAGGCGGCAGGGCCGGCGCTGAGGGCGGCGCGGCCGGGCCC
GACGACGGGGGGGTGGCCGCGGCCTCCTCGGGCTCGGCCCAGGCTGCTTCATCTCCTGCGGCCTCAGTGGGCACTGGAGTTGCCGGGGGC
GCAGTATCGACGCCGGCTCCAGCTCCAGCCTCGGCTCCCGCTCCGGGTCCCTCGGCAGGGCCGCCTCCTGGACCGCCAGCCTCGCTCCTG
GACACCTGCGCCGTGTGTCAGCAGAGCTTGCAGAGCCGGCGTGAGGCGGAGCCCAAGCTGCTGCCCTGTCTTCACTCCTTCTGCCTGCGC
TGCCTGCCCGAGCCGGAGCGCCAGCTCAGCGTGCCCATCCCGGGGGGCAGCAACGGCGACATCCAGCAAGTTGGTGTAATACGGTGCCCA
GTATGCCGCCAAGAATGCAGACAGATAGACCTTGTGGATAATTATTTTGTGAAAGACACATCTGAAGCTCCTAGCAGTTCTGATGAAAAA
TCAGAACAGGTATGTACTAGTTGTGAAGACAATGCAAGTGCAGTTGGCTTTTGTGTAGAATGTGGAGAGTGGCTATGTAAGACATGTATC
GAAGCACATCAAAGAGTAAAATTTACTAAAGATCACTTGATCAGGAAGAAAGAAGATGTCTCAGAGTCTGTTGGAGCATCTGGTCAACGC
CCTGTTTTCTGCCCTGTACACAAACAAGAACAGTTGAAACTTTTCTGTGAAACATGTGATAGATTGACATGTAGAGACTGTCAGCTATTG
GAACACAAAGAACATAGGTATCAGTTTTTGGAAGAAGCTTTTCAAAATCAGAAGGGTGCAATTGAGAATCTACTGGCGAAACTTCTTGAG
AAGAAGAATTATGTTCATTTTGCAGCTACTCAGGTGCAGAATAGGATAAAAGAAGTAAATGAGACTAACAAACGAGTAGAACAGGAAATT
AAAGTGGCCATTTTCACCCTTATCAATGAAATTAATAAGAAAGGAAAATCTCTCTTACAACAGCTAGAGAATGTTACAAAGGAAAGACAG
ATGAAGTTACTACAGCAGCAGAATGACATCACAGGCCTTTCCCGGCAGGTGAAGCATGTTATGAACTTCACAAATTGGGCAATTGCAAGT
GGCAGCAGCACAGCACTACTATACAGCAAGCGACTGATTACTTTCCAGTTGCGTCATATTTTGAAAGCACGGTGTGATCCTGTCCCTGCT
GCTAATGGAGCAATACGTTTCCATTGTGATCCCACCTTCTGGGCAAAGAATGTAGTCAATTTAGGTAATCTAGTAATAGAGAGTAAACCA
GCTCCTGGTTATACTCCTAATGTTGTAGTTGGGCAAGTTCCTCCAGGGACAAACCACATTAGTAAAACCCCTGGACAGATTAACTTAGCA
CAGCTTCGACTCCAGCACATGCAACAACAAGTATATGCACAGAAACATCAGCAGTTGCAACAGATGAGGATGCAGCAACCACCAGCACCT
GTACCAACTACAACAACAACAACACAACAGCATCCTAGACAAGCAGCCCCTCAGATGTTACAACAACAGCCTCCTCGATTGATCAGTGTG
CAAACAATGCAAAGAGGCAACATGAACTGTGGAGCTTTTCAAGCCCATCAGATGAGACTGGCTCAGAATGCTGCCAGAATACCAGGGATA
CCCAGGCACAGCGGCCCTCAATATTCCATGATGCAGCCACACCTCCAAAGACAACACTCAAACCCAGGGCATGCTGGACCCTTTCCCGTA
GTATCGGTACACAACACCACAATCAACCCAACGAGCCCTACTACAGCAACTATGGCAAATGCAAACCGAGGTCCCACCAGCCCATCTGTT
ACAGCAATAGAGCTAATCCCCTCAGTTACCAATCCAGAAAACCTTCCATCGCTGCCAGATATTCCACCCATACAGGAGGATCCAAAGTGG
GAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAA
GGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAAC
GTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCC
AAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCC
CTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAG
ATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGA
GATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATC
TACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCT
GAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGC
TGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGAC
CTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCC
CTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCC
CTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTA
AATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATT
GCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGG
GTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGC
ACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCG
AGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAG
GACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAG
TTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAAACTCCTTCTTTTGTCTTTG

>In-frame_ENST00000369543_ENST00000340058_TCGA-55-6543-01A_TRIM33_chr1_114964058_-_RET_chr10_43612032_length(amino acids)=1075AA_start in transcript=0_stop in transcript=3227
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA
KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQC

--------------------------------------------------------------
>In-frame_ENST00000358465_ENST00000355710_TCGA-55-6543_TRIM33_chr1_114964057_-_RET_chr10_43612031_length(transcript)=5436nt_BP=2145nt
CTGCGGCTGGGGCTGGGGGCGGCGGCGGCGGCGACGCGGGCGGCGGGCGGCGCGGGGCGGTCCGGCGGGTTCAAAGAGGAAAACATGGCG
GAAAACAAAGGCGGCGGCGAGGCTGAGAGCGGCGGCGGGGGCAGCGGCAGCGCGCCGGTAACTGCCGGGGCCGCCGGGCCCGCCGCGCAG
GAGGCGGAGCCGCCTCTCACCGCGGTGCTGGTGGAGGAGGAGGAGGAGGAAGGCGGCAGGGCCGGCGCTGAGGGCGGCGCGGCCGGGCCC
GACGACGGGGGGGTGGCCGCGGCCTCCTCGGGCTCGGCCCAGGCTGCTTCATCTCCTGCGGCCTCAGTGGGCACTGGAGTTGCCGGGGGC
GCAGTATCGACGCCGGCTCCAGCTCCAGCCTCGGCTCCCGCTCCGGGTCCCTCGGCAGGGCCGCCTCCTGGACCGCCAGCCTCGCTCCTG
GACACCTGCGCCGTGTGTCAGCAGAGCTTGCAGAGCCGGCGTGAGGCGGAGCCCAAGCTGCTGCCCTGTCTTCACTCCTTCTGCCTGCGC
TGCCTGCCCGAGCCGGAGCGCCAGCTCAGCGTGCCCATCCCGGGGGGCAGCAACGGCGACATCCAGCAAGTTGGTGTAATACGGTGCCCA
GTATGCCGCCAAGAATGCAGACAGATAGACCTTGTGGATAATTATTTTGTGAAAGACACATCTGAAGCTCCTAGCAGTTCTGATGAAAAA
TCAGAACAGGTATGTACTAGTTGTGAAGACAATGCAAGTGCAGTTGGCTTTTGTGTAGAATGTGGAGAGTGGCTATGTAAGACATGTATC
GAAGCACATCAAAGAGTAAAATTTACTAAAGATCACTTGATCAGGAAGAAAGAAGATGTCTCAGAGTCTGTTGGAGCATCTGGTCAACGC
CCTGTTTTCTGCCCTGTACACAAACAAGAACAGTTGAAACTTTTCTGTGAAACATGTGATAGATTGACATGTAGAGACTGTCAGCTATTG
GAACACAAAGAACATAGGTATCAGTTTTTGGAAGAAGCTTTTCAAAATCAGAAGGGTGCAATTGAGAATCTACTGGCGAAACTTCTTGAG
AAGAAGAATTATGTTCATTTTGCAGCTACTCAGGTGCAGAATAGGATAAAAGAAGTAAATGAGACTAACAAACGAGTAGAACAGGAAATT
AAAGTGGCCATTTTCACCCTTATCAATGAAATTAATAAGAAAGGAAAATCTCTCTTACAACAGCTAGAGAATGTTACAAAGGAAAGACAG
ATGAAGTTACTACAGCAGCAGAATGACATCACAGGCCTTTCCCGGCAGGTGAAGCATGTTATGAACTTCACAAATTGGGCAATTGCAAGT
GGCAGCAGCACAGCACTACTATACAGCAAGCGACTGATTACTTTCCAGTTGCGTCATATTTTGAAAGCACGGTGTGATCCTGTCCCTGCT
GCTAATGGAGCAATACGTTTCCATTGTGATCCCACCTTCTGGGCAAAGAATGTAGTCAATTTAGGTAATCTAGTAATAGAGAGTAAACCA
GCTCCTGGTTATACTCCTAATGTTGTAGTTGGGCAAGTTCCTCCAGGGACAAACCACATTAGTAAAACCCCTGGACAGATTAACTTAGCA
CAGCTTCGACTCCAGCACATGCAACAACAAGTATATGCACAGAAACATCAGCAGTTGCAACAGATGAGGATGCAGCAACCACCAGCACCT
GTACCAACTACAACAACAACAACACAACAGCATCCTAGACAAGCAGCCCCTCAGATGTTACAACAACAGCCTCCTCGATTGATCAGTGTG
CAAACAATGCAAAGAGGCAACATGAACTGTGGAGCTTTTCAAGCCCATCAGATGAGACTGGCTCAGAATGCTGCCAGAATACCAGGGATA
CCCAGGCACAGCGGCCCTCAATATTCCATGATGCAGCCACACCTCCAAAGACAACACTCAAACCCAGGGCATGCTGGACCCTTTCCCGTA
GTATCGGTACACAACACCACAATCAACCCAACGAGCCCTACTACAGCAACTATGGCAAATGCAAACCGAGGTCCCACCAGCCCATCTGTT
ACAGCAATAGAGCTAATCCCCTCAGTTACCAATCCAGAAAACCTTCCATCGCTGCCAGATATTCCACCCATACAGGAGGATCCAAAGTGG
GAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAA
GGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAAC
GTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCC
AAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCC
CTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAG
ATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGA
GATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATC
TACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCT
GAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGC
TGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGAC
CTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCC
CTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTC
ACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAA
TTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCG
GCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGG
TGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCT
TTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTT
ACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACAC
ACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAA
TGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCAT
GCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTA
CTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAG
CAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATC
CCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGT
ACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACT
GCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCT
GTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGT
TTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACT
GTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAA
TACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTG
TGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACA
CTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAAT
AAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCA
GGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAA
AGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTA
ATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAATCAAGGTGACTAAGA

>In-frame_ENST00000358465_ENST00000355710_TCGA-55-6543_TRIM33_chr1_114964057_-_RET_chr10_43612031_length(amino acids)=1117AA_start in transcript=0_stop in transcript=3353
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA
KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQC
WKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPL

--------------------------------------------------------------
>In-frame_ENST00000358465_ENST00000340058_TCGA-55-6543_TRIM33_chr1_114964057_-_RET_chr10_43612031_length(transcript)=3978nt_BP=2145nt
CTGCGGCTGGGGCTGGGGGCGGCGGCGGCGGCGACGCGGGCGGCGGGCGGCGCGGGGCGGTCCGGCGGGTTCAAAGAGGAAAACATGGCG
GAAAACAAAGGCGGCGGCGAGGCTGAGAGCGGCGGCGGGGGCAGCGGCAGCGCGCCGGTAACTGCCGGGGCCGCCGGGCCCGCCGCGCAG
GAGGCGGAGCCGCCTCTCACCGCGGTGCTGGTGGAGGAGGAGGAGGAGGAAGGCGGCAGGGCCGGCGCTGAGGGCGGCGCGGCCGGGCCC
GACGACGGGGGGGTGGCCGCGGCCTCCTCGGGCTCGGCCCAGGCTGCTTCATCTCCTGCGGCCTCAGTGGGCACTGGAGTTGCCGGGGGC
GCAGTATCGACGCCGGCTCCAGCTCCAGCCTCGGCTCCCGCTCCGGGTCCCTCGGCAGGGCCGCCTCCTGGACCGCCAGCCTCGCTCCTG
GACACCTGCGCCGTGTGTCAGCAGAGCTTGCAGAGCCGGCGTGAGGCGGAGCCCAAGCTGCTGCCCTGTCTTCACTCCTTCTGCCTGCGC
TGCCTGCCCGAGCCGGAGCGCCAGCTCAGCGTGCCCATCCCGGGGGGCAGCAACGGCGACATCCAGCAAGTTGGTGTAATACGGTGCCCA
GTATGCCGCCAAGAATGCAGACAGATAGACCTTGTGGATAATTATTTTGTGAAAGACACATCTGAAGCTCCTAGCAGTTCTGATGAAAAA
TCAGAACAGGTATGTACTAGTTGTGAAGACAATGCAAGTGCAGTTGGCTTTTGTGTAGAATGTGGAGAGTGGCTATGTAAGACATGTATC
GAAGCACATCAAAGAGTAAAATTTACTAAAGATCACTTGATCAGGAAGAAAGAAGATGTCTCAGAGTCTGTTGGAGCATCTGGTCAACGC
CCTGTTTTCTGCCCTGTACACAAACAAGAACAGTTGAAACTTTTCTGTGAAACATGTGATAGATTGACATGTAGAGACTGTCAGCTATTG
GAACACAAAGAACATAGGTATCAGTTTTTGGAAGAAGCTTTTCAAAATCAGAAGGGTGCAATTGAGAATCTACTGGCGAAACTTCTTGAG
AAGAAGAATTATGTTCATTTTGCAGCTACTCAGGTGCAGAATAGGATAAAAGAAGTAAATGAGACTAACAAACGAGTAGAACAGGAAATT
AAAGTGGCCATTTTCACCCTTATCAATGAAATTAATAAGAAAGGAAAATCTCTCTTACAACAGCTAGAGAATGTTACAAAGGAAAGACAG
ATGAAGTTACTACAGCAGCAGAATGACATCACAGGCCTTTCCCGGCAGGTGAAGCATGTTATGAACTTCACAAATTGGGCAATTGCAAGT
GGCAGCAGCACAGCACTACTATACAGCAAGCGACTGATTACTTTCCAGTTGCGTCATATTTTGAAAGCACGGTGTGATCCTGTCCCTGCT
GCTAATGGAGCAATACGTTTCCATTGTGATCCCACCTTCTGGGCAAAGAATGTAGTCAATTTAGGTAATCTAGTAATAGAGAGTAAACCA
GCTCCTGGTTATACTCCTAATGTTGTAGTTGGGCAAGTTCCTCCAGGGACAAACCACATTAGTAAAACCCCTGGACAGATTAACTTAGCA
CAGCTTCGACTCCAGCACATGCAACAACAAGTATATGCACAGAAACATCAGCAGTTGCAACAGATGAGGATGCAGCAACCACCAGCACCT
GTACCAACTACAACAACAACAACACAACAGCATCCTAGACAAGCAGCCCCTCAGATGTTACAACAACAGCCTCCTCGATTGATCAGTGTG
CAAACAATGCAAAGAGGCAACATGAACTGTGGAGCTTTTCAAGCCCATCAGATGAGACTGGCTCAGAATGCTGCCAGAATACCAGGGATA
CCCAGGCACAGCGGCCCTCAATATTCCATGATGCAGCCACACCTCCAAAGACAACACTCAAACCCAGGGCATGCTGGACCCTTTCCCGTA
GTATCGGTACACAACACCACAATCAACCCAACGAGCCCTACTACAGCAACTATGGCAAATGCAAACCGAGGTCCCACCAGCCCATCTGTT
ACAGCAATAGAGCTAATCCCCTCAGTTACCAATCCAGAAAACCTTCCATCGCTGCCAGATATTCCACCCATACAGGAGGATCCAAAGTGG
GAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAA
GGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAAC
GTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCC
AAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCC
CTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAG
ATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGA
GATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATC
TACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCT
GAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGC
TGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGAC
CTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCC
CTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCC
CTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTA
AATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATT
GCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGG
GTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGC
ACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCG
AGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAG
GACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAG
TTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAAACTCCTTCTTTTGTCTTTG

>In-frame_ENST00000358465_ENST00000340058_TCGA-55-6543_TRIM33_chr1_114964057_-_RET_chr10_43612031_length(amino acids)=1075AA_start in transcript=0_stop in transcript=3227
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA
KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQC

--------------------------------------------------------------
>In-frame_ENST00000369543_ENST00000355710_TCGA-55-6543_TRIM33_chr1_114964057_-_RET_chr10_43612031_length(transcript)=5436nt_BP=2145nt
CTGCGGCTGGGGCTGGGGGCGGCGGCGGCGGCGACGCGGGCGGCGGGCGGCGCGGGGCGGTCCGGCGGGTTCAAAGAGGAAAACATGGCG
GAAAACAAAGGCGGCGGCGAGGCTGAGAGCGGCGGCGGGGGCAGCGGCAGCGCGCCGGTAACTGCCGGGGCCGCCGGGCCCGCCGCGCAG
GAGGCGGAGCCGCCTCTCACCGCGGTGCTGGTGGAGGAGGAGGAGGAGGAAGGCGGCAGGGCCGGCGCTGAGGGCGGCGCGGCCGGGCCC
GACGACGGGGGGGTGGCCGCGGCCTCCTCGGGCTCGGCCCAGGCTGCTTCATCTCCTGCGGCCTCAGTGGGCACTGGAGTTGCCGGGGGC
GCAGTATCGACGCCGGCTCCAGCTCCAGCCTCGGCTCCCGCTCCGGGTCCCTCGGCAGGGCCGCCTCCTGGACCGCCAGCCTCGCTCCTG
GACACCTGCGCCGTGTGTCAGCAGAGCTTGCAGAGCCGGCGTGAGGCGGAGCCCAAGCTGCTGCCCTGTCTTCACTCCTTCTGCCTGCGC
TGCCTGCCCGAGCCGGAGCGCCAGCTCAGCGTGCCCATCCCGGGGGGCAGCAACGGCGACATCCAGCAAGTTGGTGTAATACGGTGCCCA
GTATGCCGCCAAGAATGCAGACAGATAGACCTTGTGGATAATTATTTTGTGAAAGACACATCTGAAGCTCCTAGCAGTTCTGATGAAAAA
TCAGAACAGGTATGTACTAGTTGTGAAGACAATGCAAGTGCAGTTGGCTTTTGTGTAGAATGTGGAGAGTGGCTATGTAAGACATGTATC
GAAGCACATCAAAGAGTAAAATTTACTAAAGATCACTTGATCAGGAAGAAAGAAGATGTCTCAGAGTCTGTTGGAGCATCTGGTCAACGC
CCTGTTTTCTGCCCTGTACACAAACAAGAACAGTTGAAACTTTTCTGTGAAACATGTGATAGATTGACATGTAGAGACTGTCAGCTATTG
GAACACAAAGAACATAGGTATCAGTTTTTGGAAGAAGCTTTTCAAAATCAGAAGGGTGCAATTGAGAATCTACTGGCGAAACTTCTTGAG
AAGAAGAATTATGTTCATTTTGCAGCTACTCAGGTGCAGAATAGGATAAAAGAAGTAAATGAGACTAACAAACGAGTAGAACAGGAAATT
AAAGTGGCCATTTTCACCCTTATCAATGAAATTAATAAGAAAGGAAAATCTCTCTTACAACAGCTAGAGAATGTTACAAAGGAAAGACAG
ATGAAGTTACTACAGCAGCAGAATGACATCACAGGCCTTTCCCGGCAGGTGAAGCATGTTATGAACTTCACAAATTGGGCAATTGCAAGT
GGCAGCAGCACAGCACTACTATACAGCAAGCGACTGATTACTTTCCAGTTGCGTCATATTTTGAAAGCACGGTGTGATCCTGTCCCTGCT
GCTAATGGAGCAATACGTTTCCATTGTGATCCCACCTTCTGGGCAAAGAATGTAGTCAATTTAGGTAATCTAGTAATAGAGAGTAAACCA
GCTCCTGGTTATACTCCTAATGTTGTAGTTGGGCAAGTTCCTCCAGGGACAAACCACATTAGTAAAACCCCTGGACAGATTAACTTAGCA
CAGCTTCGACTCCAGCACATGCAACAACAAGTATATGCACAGAAACATCAGCAGTTGCAACAGATGAGGATGCAGCAACCACCAGCACCT
GTACCAACTACAACAACAACAACACAACAGCATCCTAGACAAGCAGCCCCTCAGATGTTACAACAACAGCCTCCTCGATTGATCAGTGTG
CAAACAATGCAAAGAGGCAACATGAACTGTGGAGCTTTTCAAGCCCATCAGATGAGACTGGCTCAGAATGCTGCCAGAATACCAGGGATA
CCCAGGCACAGCGGCCCTCAATATTCCATGATGCAGCCACACCTCCAAAGACAACACTCAAACCCAGGGCATGCTGGACCCTTTCCCGTA
GTATCGGTACACAACACCACAATCAACCCAACGAGCCCTACTACAGCAACTATGGCAAATGCAAACCGAGGTCCCACCAGCCCATCTGTT
ACAGCAATAGAGCTAATCCCCTCAGTTACCAATCCAGAAAACCTTCCATCGCTGCCAGATATTCCACCCATACAGGAGGATCCAAAGTGG
GAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAA
GGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAAC
GTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCC
AAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCC
CTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAG
ATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGA
GATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATC
TACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCT
GAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGC
TGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGAC
CTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCC
CTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTC
ACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAA
TTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCG
GCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGG
TGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCT
TTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTT
ACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACAC
ACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAA
TGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCAT
GCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTA
CTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAG
CAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATC
CCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGT
ACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACT
GCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCT
GTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGT
TTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACT
GTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAA
TACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTG
TGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACA
CTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAAT
AAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCA
GGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAA
AGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTA
ATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAATCAAGGTGACTAAGA

>In-frame_ENST00000369543_ENST00000355710_TCGA-55-6543_TRIM33_chr1_114964057_-_RET_chr10_43612031_length(amino acids)=1117AA_start in transcript=0_stop in transcript=3353
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA
KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQC
WKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPL

--------------------------------------------------------------
>In-frame_ENST00000369543_ENST00000340058_TCGA-55-6543_TRIM33_chr1_114964057_-_RET_chr10_43612031_length(transcript)=3978nt_BP=2145nt
CTGCGGCTGGGGCTGGGGGCGGCGGCGGCGGCGACGCGGGCGGCGGGCGGCGCGGGGCGGTCCGGCGGGTTCAAAGAGGAAAACATGGCG
GAAAACAAAGGCGGCGGCGAGGCTGAGAGCGGCGGCGGGGGCAGCGGCAGCGCGCCGGTAACTGCCGGGGCCGCCGGGCCCGCCGCGCAG
GAGGCGGAGCCGCCTCTCACCGCGGTGCTGGTGGAGGAGGAGGAGGAGGAAGGCGGCAGGGCCGGCGCTGAGGGCGGCGCGGCCGGGCCC
GACGACGGGGGGGTGGCCGCGGCCTCCTCGGGCTCGGCCCAGGCTGCTTCATCTCCTGCGGCCTCAGTGGGCACTGGAGTTGCCGGGGGC
GCAGTATCGACGCCGGCTCCAGCTCCAGCCTCGGCTCCCGCTCCGGGTCCCTCGGCAGGGCCGCCTCCTGGACCGCCAGCCTCGCTCCTG
GACACCTGCGCCGTGTGTCAGCAGAGCTTGCAGAGCCGGCGTGAGGCGGAGCCCAAGCTGCTGCCCTGTCTTCACTCCTTCTGCCTGCGC
TGCCTGCCCGAGCCGGAGCGCCAGCTCAGCGTGCCCATCCCGGGGGGCAGCAACGGCGACATCCAGCAAGTTGGTGTAATACGGTGCCCA
GTATGCCGCCAAGAATGCAGACAGATAGACCTTGTGGATAATTATTTTGTGAAAGACACATCTGAAGCTCCTAGCAGTTCTGATGAAAAA
TCAGAACAGGTATGTACTAGTTGTGAAGACAATGCAAGTGCAGTTGGCTTTTGTGTAGAATGTGGAGAGTGGCTATGTAAGACATGTATC
GAAGCACATCAAAGAGTAAAATTTACTAAAGATCACTTGATCAGGAAGAAAGAAGATGTCTCAGAGTCTGTTGGAGCATCTGGTCAACGC
CCTGTTTTCTGCCCTGTACACAAACAAGAACAGTTGAAACTTTTCTGTGAAACATGTGATAGATTGACATGTAGAGACTGTCAGCTATTG
GAACACAAAGAACATAGGTATCAGTTTTTGGAAGAAGCTTTTCAAAATCAGAAGGGTGCAATTGAGAATCTACTGGCGAAACTTCTTGAG
AAGAAGAATTATGTTCATTTTGCAGCTACTCAGGTGCAGAATAGGATAAAAGAAGTAAATGAGACTAACAAACGAGTAGAACAGGAAATT
AAAGTGGCCATTTTCACCCTTATCAATGAAATTAATAAGAAAGGAAAATCTCTCTTACAACAGCTAGAGAATGTTACAAAGGAAAGACAG
ATGAAGTTACTACAGCAGCAGAATGACATCACAGGCCTTTCCCGGCAGGTGAAGCATGTTATGAACTTCACAAATTGGGCAATTGCAAGT
GGCAGCAGCACAGCACTACTATACAGCAAGCGACTGATTACTTTCCAGTTGCGTCATATTTTGAAAGCACGGTGTGATCCTGTCCCTGCT
GCTAATGGAGCAATACGTTTCCATTGTGATCCCACCTTCTGGGCAAAGAATGTAGTCAATTTAGGTAATCTAGTAATAGAGAGTAAACCA
GCTCCTGGTTATACTCCTAATGTTGTAGTTGGGCAAGTTCCTCCAGGGACAAACCACATTAGTAAAACCCCTGGACAGATTAACTTAGCA
CAGCTTCGACTCCAGCACATGCAACAACAAGTATATGCACAGAAACATCAGCAGTTGCAACAGATGAGGATGCAGCAACCACCAGCACCT
GTACCAACTACAACAACAACAACACAACAGCATCCTAGACAAGCAGCCCCTCAGATGTTACAACAACAGCCTCCTCGATTGATCAGTGTG
CAAACAATGCAAAGAGGCAACATGAACTGTGGAGCTTTTCAAGCCCATCAGATGAGACTGGCTCAGAATGCTGCCAGAATACCAGGGATA
CCCAGGCACAGCGGCCCTCAATATTCCATGATGCAGCCACACCTCCAAAGACAACACTCAAACCCAGGGCATGCTGGACCCTTTCCCGTA
GTATCGGTACACAACACCACAATCAACCCAACGAGCCCTACTACAGCAACTATGGCAAATGCAAACCGAGGTCCCACCAGCCCATCTGTT
ACAGCAATAGAGCTAATCCCCTCAGTTACCAATCCAGAAAACCTTCCATCGCTGCCAGATATTCCACCCATACAGGAGGATCCAAAGTGG
GAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAA
GGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAAC
GTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCC
AAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCC
CTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAG
ATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGA
GATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATC
TACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCT
GAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGC
TGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGAC
CTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCC
CTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCC
CTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTA
AATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATT
GCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGG
GTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGC
ACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCG
AGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAG
GACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAG
TTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAAACTCCTTCTTTTGTCTTTG

>In-frame_ENST00000369543_ENST00000340058_TCGA-55-6543_TRIM33_chr1_114964057_-_RET_chr10_43612031_length(amino acids)=1075AA_start in transcript=0_stop in transcript=3227
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA
KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TRIM33-RET


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRIM33-RET


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRIM33-RET


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIM33C0238463Papillary thyroid carcinoma2ORPHANET
TgeneRETC1833921Familial medullary thyroid carcinoma23CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC3888239HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 116GENOMICS_ENGLAND;UNIPROT
TgeneRETC0025268Multiple Endocrine Neoplasia Type 2a15CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome12CLINGEN
TgeneRETC0025269Multiple Endocrine Neoplasia Type 2b10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC0238463Papillary thyroid carcinoma3CTD_human;ORPHANET
TgeneRETC1275808Congenital central hypoventilation3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRETC1859049CCHS WITH HIRSCHSPRUNG DISEASE3CTD_human;ORPHANET
TgeneRETC0009402Colorectal Carcinoma2CTD_human;UNIPROT
TgeneRETC0009404Colorectal Neoplasms2CTD_human
TgeneRETC0019569Hirschsprung Disease2CTD_human
TgeneRETC0027662Multiple Endocrine Neoplasia2CTD_human;GENOMICS_ENGLAND
TgeneRETC0085758Aganglionosis, Colonic2CTD_human
TgeneRETC0266294Unilateral agenesis of kidney2ORPHANET
TgeneRETC1257840Aganglionosis, Rectosigmoid Colon2CTD_human
TgeneRETC3661523Congenital Intestinal Aganglionosis2CTD_human
TgeneRETC0006413Burkitt Lymphoma1CTD_human
TgeneRETC0031511Pheochromocytoma1CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRETC0038220Status Epilepticus1CTD_human
TgeneRETC0040136Thyroid Neoplasm1CGI;CTD_human
TgeneRETC0151468Thyroid Gland Follicular Adenoma1CTD_human
TgeneRETC0206693Medullary carcinoma1CTD_human
TgeneRETC0238462Medullary carcinoma of thyroid1CGI;CTD_human
TgeneRETC0270823Petit mal status1CTD_human
TgeneRETC0311335Grand Mal Status Epilepticus1CTD_human
TgeneRETC0343640African Burkitt's lymphoma1CTD_human
TgeneRETC0393734Complex Partial Status Epilepticus1CTD_human
TgeneRETC0549473Thyroid carcinoma1CGI;CTD_human;UNIPROT
TgeneRETC0740340Amyloidosis, Familial1CTD_human
TgeneRETC0751522Status Epilepticus, Subclinical1CTD_human
TgeneRETC0751523Non-Convulsive Status Epilepticus1CTD_human
TgeneRETC0751524Simple Partial Status Epilepticus1CTD_human
TgeneRETC1257877Pheochromocytoma, Extra-Adrenal1CTD_human
TgeneRETC1609433Congenital absence of kidneys syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneRETC3501843Nonmedullary Thyroid Carcinoma1CTD_human
TgeneRETC3501844Familial Nonmedullary Thyroid Cancer1CTD_human
TgeneRETC4721444Burkitt Leukemia1CTD_human